The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article A functional circuit underlying male sexual behaviour in the female mouse brain
Tali Kimchi, Jennings Xu & Catherine Dulac Nature448, 1009–1014
(30 August 2007); doi:10.1038/nature06089
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news and views Behavioural neurobiology: Females can also be from Mars
Nirao M. Shah & S. Marc Breedlove Nature448, 999–1000
(30 August 2007); doi:10.1038/nature05892
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article IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
Sean C. Bendall, Morag H. Stewart, Pablo Menendez, Dustin George, Kausalia Vijayaragavan, Tamra Werbowetski-Ogilvie, Veronica Ramos-Mejia, Anne Rouleau, Jiabi Yang, Marc Bossé, Gilles Lajoie & Mickie Bhatia Nature448, 1015–1021
(30 August 2007); doi:10.1038/nature06027
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letter The detection of carbonation by the Drosophila gustatory system
Walter Fischler, Priscilla Kong, Sunanda Marella & Kristin Scott Nature448, 1054–1057
(30 August 2007); doi:10.1038/nature06101
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letter Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Yoshiyuki Minegishi, Masako Saito, Shigeru Tsuchiya, Ikuya Tsuge, Hidetoshi Takada, Toshiro Hara, Nobuaki Kawamura, Tadashi Ariga, Srdjan Pasic, Oliver Stojkovic, Ayse Metin & Hajime Karasuyama Nature448, 1058–1062
(30 August 2007); doi:10.1038/nature06096
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letter Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Chiara Gorrini, Massimo Squatrito, Chiara Luise, Nelofer Syed, Daniele Perna, Landon Wark, Francesca Martinato, Domenico Sardella, Alessandro Verrecchia, Samantha Bennett, Stefano Confalonieri, Matteo Cesaroni, Francesco Marchesi, Milena Gasco, Eugenio Scanziani, Maria Capra, Sabine Mai, Paolo Nuciforo, Tim Crook, John Lough & Bruno Amati Nature448, 1063–1067
(30 August 2007); doi:10.1038/nature06055
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letter Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi & Titia de Lange Nature448, 1068–1071
(30 August 2007); doi:10.1038/nature06065
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letter Crystal structure of the MgtE Mg2+ transporter
Motoyuki Hattori, Yoshiki Tanaka, Shuya Fukai, Ryuichiro Ishitani & Osamu Nureki Nature448, 1072–1075
(30 August 2007); doi:10.1038/nature06093
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article Cables links Robo-bound Abl kinase to N-cadherin-bound β-catenin to mediate Slit-induced modulation of adhesion and transcription
Jinseol Rhee, Tim Buchan, Lawrence Zukerberg, Jack Lilien & Janne Balsamo Nature Cell Biology9, 883–892
(August 2007); doi:10.1038/ncb1614
| Summary | Full Text (HTML / PDF) |
article Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
Tianhai Tian, Angus Harding, Kerry Inder, Sarah Plowman, Robert G. Parton & John F. Hancock Nature Cell Biology9, 905–914
(August 2007); doi:10.1038/ncb1615
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news and views Nanoclusters digitize Ras signalling
Anne K. Kenworthy Nature Cell Biology9, 875–877
(August 2007); doi:10.1038/ncb0807-875
| Summary | Full Text (HTML / PDF) |
review Filling out the Hippo pathway
Leslie J. Saucedo & Bruce A. Edgar Nature Reviews Molecular Cell Biology8, 613–621
(August 2007); doi:10.1038/nrm2221
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review The ins and outs of the plant cell cycle
Lieven De Veylder, Tom Beeckman & Dirk Inzé Nature Reviews Molecular Cell Biology8, 655–665
(August 2007); doi:10.1038/nrm2227
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article Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
Marta A Toscano, Germán A Bianco, Juan M Ilarregui, Diego O Croci, Jorge Correale, Joseph D Hernandez, Norberto W Zwirner, Francoise Poirier, Eleanor M Riley, Linda G Baum & Gabriel A Rabinovich Nature Immunology8, 825–834
(August 2007); doi:10.1038/ni1482
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review B-cell anergy: from transgenic models to naturally occurring anergic B cells?
John C. Cambier, Stephen B. Gauld, Kevin T. Merrell & Barbara J. Vilen Nature Reviews Immunology7, 633–643
(August 2007); doi:10.1038/nri2133
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article E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
Kurt Bachmaier, Sophie Toya, Xiaopei Gao, Thomas Triantafillou, Sean Garrean, Gye Young Park, Randall S Frey, Stephen Vogel, Richard Minshall, John W Christman, Chinnaswamy Tiruppathi & Asrar B Malik Nature Medicine13, 920–926
(August 2007); doi:10.1038/nm1607
| Summary | Full Text (HTML / PDF) |
review Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
Teru Hideshima, Constantine Mitsiades, Giovanni Tonon, Paul G. Richardson & Kenneth C. Anderson Nature Reviews Cancer7, 585–598
(August 2007); doi:10.1038/nrc2189
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letter Germline gain-of-function mutations in RAF1 cause Noonan syndrome
M Abdur Razzaque, Tsutomu Nishizawa, Yuta Komoike, Hisato Yagi, Michiko Furutani, Ryunosuke Amo, Mitsuhiro Kamisago, Kazuo Momma, Hiroshi Katayama, Masao Nakagawa, Yuko Fujiwara, Masaki Matsushima, Katsumi Mizuno, Mika Tokuyama, Hamao Hirota, Jun Muneuchi, Toru Higashinakagawa & Rumiko Matsuoka Nature Genetics39, 1013–1017
(August 2007); doi:10.1038/ng2078
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article Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue
Jin-Wu Tsai, K Helen Bremner & Richard B Vallee Nature Neuroscience10, 970–979
(August 2007); doi:10.1038/nn1934
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article A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport
Eunju Pack-Chung, Peri T Kurshan, Dion K Dickman & Thomas L Schwarz Nature Neuroscience10, 980–989
(August 2007); doi:10.1038/nn1936
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article A hippocampal Cdk5 pathway regulates extinction of contextual fear
Farahnaz Sananbenesi, Andre Fischer, Xinyu Wang, Christina Schrick, Rachael Neve, Jelena Radulovic & Li-Huei Tsai Nature Neuroscience10, 1012–1019
(August 2007); doi:10.1038/nn1943
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review The sequence of events that underlie quantal transmission at central glutamatergic synapses
John E. Lisman, Sridhar Raghavachari & Richard W. Tsien Nature Reviews Neuroscience8, 597–609
(August 2007); doi:10.1038/nrn2191
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article Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
Farbod Shojaei, Xiumin Wu, Ajay K Malik, Cuiling Zhong, Megan E Baldwin, Stefanie Schanz, Germaine Fuh, Hans-Peter Gerber & Napoleone Ferrara Nature Biotechnology25, 911–920
(August 2007); doi:10.1038/nbt1323
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article Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Xiao-Qing Qiu, He Wang, Bei Cai, Lan-Lan Wang & Shi-Tao Yue Nature Biotechnology25, 921–929
(August 2007); doi:10.1038/nbt1320
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news and views Antibodies cut down to size
Robert Charles Ladner Nature Biotechnology25, 875–877
(August 2007); doi:10.1038/nbt0807-875
| Summary | Full Text (HTML / PDF) |
news and views Gene expression analysis goes digital
Victor E Velculescu & Kenneth W Kinzler Nature Biotechnology25, 878–880
(August 2007); doi:10.1038/nbt0807-878
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review Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface
Timothy A. McKinsey & David A. Kass Nature Reviews Drug Discovery6, 617–635
(August 2007); doi:10.1038/nrd2193
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article Rad54 dissociates homologous recombination intermediates by branch migration
Dmitry V Bugreev, Fumio Hanaoka & Alexander V Mazin Nature Structural & Molecular Biology14, 746–753
(August 2007); doi:10.1038/nsmb1268
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brief communication Luciferase–YFP fusion tag with enhanced emission for single-cell luminescence imaging
Hideto Hoshino, Yoshihiro Nakajima & Yoshihiro Ohmiya Nature Methods4, 637–639
(August 2007); doi:10.1038/nmeth1069
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brief communication Red-shifted Renilla reniformis luciferase variants for imaging in living subjects
Andreas Markus Loening, Anna M Wu & Sanjiv Sam Gambhir Nature Methods4, 641–643
(August 2007); doi:10.1038/nmeth1070
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news and views Bringing bioluminescence into the picture
Atsushi Miyawaki Nature Methods4, 616–617
(August 2007); doi:10.1038/nmeth0807-616
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article Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Jeffrey M. Welch, Jing Lu, Ramona M. Rodriguiz, Nicholas C. Trotta, Joao Peca, Jin-Dong Ding, Catia Feliciano, Meng Chen, J. Paige Adams, Jianhong Luo, Serena M. Dudek, Richard J. Weinberg, Nicole Calakos, William C. Wetsel & Guoping Feng Nature448, 894–900
(23 August 2007); doi:10.1038/nature06104
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news and views Neuroscience: Obsessed with grooming
Steven E. Hyman Nature448, 871–872
(23 August 2007); doi:10.1038/448871a
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article Gap junction adhesion is necessary for radial migration in the neocortex
Laura A. B. Elias, Doris D. Wang & Arnold R. Kriegstein Nature448, 901–907
(23 August 2007); doi:10.1038/nature06063
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letter Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira & Toshiaki Ohteki Nature448, 929–933
(23 August 2007); doi:10.1038/nature06033
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letter An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
Matthieu Giraud, Richard Taubert, Claire Vandiedonck, Xiayi Ke, Matthieu Lévi-Strauss, Franco Pagani, Francisco E. Baralle, Bruno Eymard, Christine Tranchant, Philippe Gajdos, Angela Vincent, Nick Willcox, David Beeson, Bruno Kyewski & Henri-Jean Garchon Nature448, 934–937
(23 August 2007); doi:10.1038/nature06066
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letter A central integrator of transcription networks in plant stress and energy signalling
Elena Baena-González, Filip Rolland, Johan M. Thevelein & Jen Sheen Nature448, 938–942
(23 August 2007); doi:10.1038/nature06069
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letter p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
Paul Krimpenfort, Annemieke IJpenberg, Ji-Ying Song, Martin van der Valk, Martijn Nawijn, John Zevenhoven & Anton Berns Nature448, 943–946
(23 August 2007); doi:10.1038/nature06084
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letter The effects of molecular noise and size control on variability in the budding yeast cell cycle
Stefano Di Talia, Jan M. Skotheim, James M. Bean, Eric D. Siggia & Frederick R. Cross Nature448, 947–951
(23 August 2007); doi:10.1038/nature06072
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article Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
Katarina Wolf, Yi I. Wu, Yueying Liu, Jörg Geiger, Eric Tam, Christopher Overall, M. Sharon Stack & Peter Friedl Nature Cell Biology9, 893–904
(August 2007); doi:10.1038/ncb1616
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article The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus
Jordi Torres-Rosell, Ivana Sunjevaric, Giacomo De Piccoli, Meik Sacher, Nadine Eckert-Boulet, Robert Reid, Stefan Jentsch, Rodney Rothstein, Luis Aragón & Michael Lisby Nature Cell Biology9, 923–931
(August 2007); doi:10.1038/ncb1619
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letter Regulated ATP release from astrocytes through lysosome exocytosis
Zhijun Zhang, Gang Chen, Wei Zhou, Aihong Song, Tao Xu, Qingming Luo, Wei Wang, Xiao-song Gu & Shumin Duan Nature Cell Biology9, 945–953
(August 2007); doi:10.1038/ncb1620
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review Analysis of protein complexes using mass spectrometry
Anne-Claude Gingras, Matthias Gstaiger, Brian Raught & Ruedi Aebersold Nature Reviews Molecular Cell Biology8, 645–654
(August 2007); doi:10.1038/nrm2208
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article Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1
Yufeng Shi, Yan Feng, Jiuhong Kang, Chang Liu, Zhenxin Li, Dangsheng Li, Wei Cao, Ju Qiu, Zhengliang Guo, Enguang Bi, Lei Zang, Chuanzhen Lu, Jingwu Z Zhang & Gang Pei Nature Immunology8, 817–824
(August 2007); doi:10.1038/ni1489
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news and views Arresting autoimmunity by blocking β-arrestin 1
Terra J Frederick & Stephen D Miller Nature Immunology8, 791–792
(August 2007); doi:10.1038/ni0807-791
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review Molecular mechanisms of CD4+ T-cell anergy
C. Garrison Fathman & Neil B. Lineberry Nature Reviews Immunology7, 599–609
(August 2007); doi:10.1038/nri2131
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article IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Elena Bulanova, Martin Metz, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Vadim Budagian, Julien Giron-Michel, Ernst Brandt, Ralf Paus & Silvia Bulfone-Paus Nature Medicine13, 927–934
(August 2007); doi:10.1038/nm1615
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news and views The curiosity of IL-15
Peter A Ward Nature Medicine13, 903–904
(August 2007); doi:10.1038/nm0807-903
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article Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Elisabeth M Zeisberg, Oleg Tarnavski, Michael Zeisberg, Adam L Dorfman, Julie R McMullen, Erika Gustafsson, Anil Chandraker, Xueli Yuan, William T Pu, Anita B Roberts, Eric G Neilson, Mohamed H Sayegh, Seigo Izumo & Raghu Kalluri Nature Medicine13, 952–961
(August 2007); doi:10.1038/nm1613
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article Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
Bernhard Kühn, Federica del Monte, Roger J Hajjar, Yuh-Shin Chang, Djamel Lebeche, Shima Arab & Mark T Keating Nature Medicine13, 962–969
(August 2007); doi:10.1038/nm1619
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perspective Active-site directed probes to report enzymatic action in the ubiquitin proteasome system
Huib Ovaa Nature Reviews Cancer7, 613–620
(August 2007); doi:10.1038/nrc2128
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letter Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Bhaswati Pandit, Anna Sarkozy, Len A Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A Pogna, Wendy Schackwitz, Anna Ustaszewska, Andrew Landstrom, J Martijn Bos, Steve R Ommen, Giorgia Esposito, Francesca Lepri, Christian Faul, Peter Mundel, Juan P López Siguero, Romano Tenconi, Angelo Selicorni, Cesare Rossi, Laura Mazzanti, Isabella Torrente, Bruno Marino, Maria C Digilio, Giuseppe Zampino, Michael J Ackerman, Bruno Dallapiccola, Marco Tartaglia & Bruce D Gelb Nature Genetics39, 1007–1012
(August 2007); doi:10.1038/ng2073
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article Opposing roles in neurite growth control by two seven-pass transmembrane cadherins
Yasuyuki Shima, Shin-ya Kawaguchi, Kazuyoshi Kosaka, Manabu Nakayama, Mikio Hoshino, Yoichi Nabeshima, Tomoo Hirano & Tadashi Uemura Nature Neuroscience10, 963–969
(August 2007); doi:10.1038/nn1933
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brief communication Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch
Qin Liu, Sophia Vrontou, Frank L Rice, Mark J Zylka, Xinzhong Dong & David J Anderson Nature Neuroscience10, 946–948
(August 2007); doi:10.1038/nn1937
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review Angiogenesis in brain tumours
Rakesh K. Jain, Emmanuelle di Tomaso, Dan G. Duda, Jay S. Loeffler, A. Gregory Sorensen & Tracy T. Batchelor Nature Reviews Neuroscience8, 610–622
(August 2007); doi:10.1038/nrn2175
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article Embryo-specific silencing of a transporter reduces phytic acid content of maize and soybean seeds
Jinrui Shi, Hongyu Wang, Kathleen Schellin, Bailin Li, Marianna Faller, Johan M Stoop, Robert B Meeley, David S Ertl, Jerry P Ranch & Kimberly Glassman Nature Biotechnology25, 930–937
(August 2007); doi:10.1038/nbt1322
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news and views The ABCs of low-phytate crops
Victor Raboy Nature Biotechnology25, 874–875
(August 2007); doi:10.1038/nbt0807-874
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article CCDC98 is a BRCA1–BRCT domain-binding protein involved in the DNA damage response
Hongtae Kim, Jun Huang & Junjie Chen Nature Structural & Molecular Biology14, 710–715
(August 2007); doi:10.1038/nsmb1277
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article CCDC98 targets BRCA1 to DNA damage sites
Zixing Liu, Jiaxue Wu & Xiaochun Yu Nature Structural & Molecular Biology14, 716–720
(August 2007); doi:10.1038/nsmb1279
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progress Beneficial suicide: why neutrophils die to make NETs
Volker Brinkmann & Arturo Zychlinsky Nature Reviews Microbiology5, 577–582
(August 2007); doi:10.1038/nrmicro1710
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article Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
Nicole-Claudia Meisner, Martin Hintersteiner, Kurt Mueller, Roman Bauer, Jan-Marcus Seifert, Hans-Ulrich Naegeli, Johannes Ottl, Lukas Oberer, Christian Guenat, Serge Moss, Nathalie Harrer, Maximilian Woisetschlaeger, Christof Buehler, Volker Uhl & Manfred Auer Nature Chemical Biology3, 508–515
(August 2007); doi:10.1038/nchembio.2007.14
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commentary Scaffold composition and biological relevance of screening libraries
Anang A Shelat & R Kiplin Guy Nature Chemical Biology3, 442–446
(August 2007); doi:10.1038/nchembio0807-442
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article Structure-based activity prediction for an enzyme of unknown function
Johannes C. Hermann, Ricardo Marti-Arbona, Alexander A. Fedorov, Elena Fedorov, Steven C. Almo, Brian K. Shoichet & Frank M. Raushel Nature448, 775–779
(16 August 2007); doi:10.1038/nature05981
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news and views Computational biochemistry: Models of transition
JoAnne Stubbe Nature448, 762–763
(16 August 2007); doi:10.1038/448762a
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letter LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji, Matthew R. Ramsey et al. Nature448, 807–810
(16 August 2007); doi:10.1038/nature06030
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letter Cdk1 is sufficient to drive the mammalian cell cycle
David Santamaría, Cédric Barrière, Antonio Cerqueira, Sarah Hunt, Claudine Tardy, Kathryn Newton, Javier F. Cáceres, Pierre Dubus, Marcos Malumbres & Mariano Barbacid Nature448, 811–815
(16 August 2007); doi:10.1038/nature06046
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letter Break-induced replication and telomerase-independent telomere maintenance require Pol32
John R. Lydeard, Suvi Jain, Miyuki Yamaguchi & James E. Haber Nature448, 820–823
(16 August 2007); doi:10.1038/nature06047
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letter Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
Burckhard Seelig & Jack W. Szostak Nature448, 828–831
(16 August 2007); doi:10.1038/nature06032
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news and views Biochemistry: Designer enzymes
Michael P. Robertson & William G. Scott Nature448, 757–763
(16 August 2007); doi:10.1038/448757a
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news and views Parkinson's disease: Pro-survival effects of PINK1
Asa Abeliovich Nature448, 759–760
(16 August 2007); doi:10.1038/448759a
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review The common biology of cancer and ageing
Toren Finkel, Manuel Serrano & Maria A. Blasco Nature448, 767–774
(16 August 2007); doi:10.1038/nature05985
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letter Genetic control of single lumen formation in the zebrafish gut
Michel Bagnat, Isla D. Cheung, Keith E. Mostov & Didier Y. R. Stainier Nature Cell Biology9, 954–960
(August 2007); doi:10.1038/ncb1621
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news and views It takes guts to make a single lumen
Heinz-Georg Belting & Markus Affolter Nature Cell Biology9, 880–881
(August 2007); doi:10.1038/ncb0807-880
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letter Cathepsin L activity controls adipogenesis and glucose tolerance
Min Yang, Yaou Zhang, Jiehong Pan, Jiusong Sun, Jian Liu, Peter Libby, Galina K. Sukhova, Alessandro Doria, Nobuhiko Katunuma, Odile D. Peroni, Michèle Guerre-Millo, Barbara B. Kahn, Karine Clement & Guo-Ping Shi Nature Cell Biology9, 978–981
(August 2007); doi:10.1038/ncb1623
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article P-selectin primes leukocyte integrin activation during inflammation
Hai-Bo Wang, Jin-Tao Wang, Lei Zhang, Zhen H Geng, Wei-Li Xu, Tao Xu, Yuqing Huo, Xueliang Zhu, Edward F Plow, Ming Chen & Jian-Guo Geng Nature Immunology8, 882–892
(August 2007); doi:10.1038/ni1491
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review Tolerogenic dendritic cells and the quest for transplant tolerance
Adrian E. Morelli & Angus W. Thomson Nature Reviews Immunology7, 610–621
(August 2007); doi:10.1038/nri2132
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perspective A decade of AIRE
Diane Mathis & Christophe Benoist Nature Reviews Immunology7, 645–650
(August 2007); doi:10.1038/nri2136
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letter Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Kenshi Yamasaki, Anna Di Nardo, Antonella Bardan, Masamoto Murakami, Takaaki Ohtake, Alvin Coda, Robert A Dorschner, Chrystelle Bonnart, Pascal Descargues, Alain Hovnanian, Vera B Morhenn & Richard L Gallo Nature Medicine13, 975–980
(August 2007); doi:10.1038/nm1616
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news and views Rosacea: skin innate immunity gone awry?
Charles L Bevins & Fu-Tong Liu Nature Medicine13, 904–906
(August 2007); doi:10.1038/nm0807-904
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article Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
Marco Idzko, Hamida Hammad, Menno van Nimwegen, Mirjam Kool, Monique A M Willart, Femke Muskens, Henk C Hoogsteden, Werner Luttmann, Davide Ferrari, Francesco Di Virgilio, J Christian Virchow, Jr & Bart N Lambrecht Nature Medicine13, 913–919
(August 2007); doi:10.1038/nm1617
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review The resurgence of platinum-based cancer chemotherapy
Lloyd Kelland Nature Reviews Cancer7, 573–584
(August 2007); doi:10.1038/nrc2167
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letter Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
Fudi Wang, Prasad N Paradkar, Angel O Custodio, Diane McVey Ward, Mark D Fleming, Dean Campagna, Kristina A Roberts, Victor Boyartchuk, William F Dietrich, Jerry Kaplan & Nancy C Andrews Nature Genetics39, 1025–1032
(August 2007); doi:10.1038/ng2059
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brief communication A tarantula peptide against pain via ASIC1a channels and opioid mechanisms
Michel Mazzuca, Catherine Heurteaux, Abdelkrim Alloui, Sylvie Diochot, Anne Baron, Nicolas Voilley, Nicolas Blondeau, Pierre Escoubas, Agnès Gélot, Anny Cupo, Andreas Zimmer, Anne M Zimmer, Alain Eschalier & Michel Lazdunski Nature Neuroscience10, 943–945
(August 2007); doi:10.1038/nn1940
| Summary | Full Text (HTML / PDF) |
review Initiation to end point: the multiple roles of fibroblast growth factors in neural development
Ivor Mason Nature Reviews Neuroscience8, 583–596
(August 2007); doi:10.1038/nrn2189
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news and views Reprogramming by the numbers
Shin-ichi Nishikawa Nature Biotechnology25, 877–878
(August 2007); doi:10.1038/nbt0807-877
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perspective Embryonic stem cells as a source of models for drug discovery
Colin W. Pouton & John M. Haynes Nature Reviews Drug Discovery6, 605–616
(August 2007); doi:10.1038/nrd2194
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article Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
Hong-Wei Wang, Vincent H Ramey, Stefan Westermann, Andres E Leschziner, Julie P I Welburn, Yuko Nakajima, David G Drubin, Georjana Barnes & Eva Nogales Nature Structural & Molecular Biology14, 721–726
(August 2007); doi:10.1038/nsmb1274
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article λN-GFP: an RNA reporter system for live-cell imaging
Nathalie Daigle & Jan Ellenberg Nature Methods4, 633–636
(August 2007); doi:10.1038/nmeth1065
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article Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Julie Litz, Cristina C Clement, Yanlong Kang, Yuhong She, Nian Wu, Sara Felts, Peter Wipf, Joan Massague, Xuejun Jiang, Jeffrey L Brodsky, Geoffrey W Krystal & Gabriela Chiosis Nature Chemical Biology3, 498–507
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news and views Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer
Paul Workman & Marissa V Powers Nature Chemical Biology3, 455–457
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article JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
Bryan Thines, Leron Katsir, Maeli Melotto, Yajie Niu, Ajin Mandaokar, Guanghui Liu, Kinya Nomura, Sheng Yang He, Gregg A. Howe & John Browse Nature448, 661–665
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article The JAZ family of repressors is the missing link in jasmonate signalling
A. Chini, S. Fonseca, G. Fernández, B. Adie, J. M. Chico, O. Lorenzo, G. García-Casado, I. López-Vidriero, F. M. Lozano, M. R. Ponce, J. L. Micol & R. Solano Nature448, 666–671
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news and views Plant biology: Jasmonate perception machines
Edward E. Farmer Nature448, 659–660
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letter A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
Yan-Gang Sun & Zhou-Feng Chen Nature448, 700–703
(9 August 2007); doi:10.1038/nature06029
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letter Global changes to the ubiquitin system in Huntington's disease
Eric J. Bennett, Thomas A. Shaler, Ben Woodman, Kwon-Yul Ryu, Tatiana S. Zaitseva, Christopher H. Becker, Gillian P. Bates, Howard Schulman & Ron R. Kopito Nature448, 704–708
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brief communications arising Crystallography: Crystallographic evidence for deviating C3b structure
Bert J. C. Janssen, Randy J. Read, Axel T. Brünger & Piet Gros Nature448, E1–E2
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brief communications arising Crystallography: Crystallographic evidence for deviating C3b structure (Reply)
A. Abdul Ajees, Krishnasamy Gunasekaran, Sthanam V. L. Narayana & H. M. Krishna Murthy Nature448, E2–E3
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news and views Chemical biology: Ions illuminated
Christopher J. Chang Nature448, 654–660
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article PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
Alessio Zippo, Alessandra De Robertis, Riccardo Serafini & Salvatore Oliviero Nature Cell Biology9, 932–944
(August 2007); doi:10.1038/ncb1618
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news and views PIM1 and MYC: a changing relationship?
Jean-Francois Naud & Martin Eilers Nature Cell Biology9, 873–875
(August 2007); doi:10.1038/ncb0807-873
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news and views Debugging cellular reprogramming
In-Hyun Park & George Q. Daley Nature Cell Biology9, 871–873
(August 2007); doi:10.1038/ncb0807-871
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review Lysosomes: fusion and function
J. Paul Luzio, Paul R. Pryor & Nicholas A. Bright Nature Reviews Molecular Cell Biology8, 622–632
(August 2007); doi:10.1038/nrm2217
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review Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
Thomas Lecuit & Pierre-François Lenne Nature Reviews Molecular Cell Biology8, 633–644
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article Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, Hyacinth Tabarias, Mariapia A Degli-Esposti, Grant Dewson, Simon N Willis, Noboru Motoyama, David C S Huang, Stephen L Nutt, David M Tarlinton & Andreas Strasser Nature Immunology8, 856–863
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review Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
Maria-Grazia Roncarolo & Manuela Battaglia Nature Reviews Immunology7, 585–598
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perspective Treating prostate cancer: a rationale for targeting local oestrogens
Stuart J. Ellem & Gail P. Risbridger Nature Reviews Cancer7, 621–627
(August 2007); doi:10.1038/nrc2174
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letter Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
Massimo Attanasio, N Henriette Uhlenhaut, Vitor H Sousa, John F O'Toole, Edgar Otto, Katrin Anlag, Claudia Klugmann, Anna-Corina Treier, Juliana Helou, John A Sayer, Dominik Seelow, Gudrun Nürnberg, Christian Becker, Albert E Chudley, Peter Nürnberg, Friedhelm Hildebrandt & Mathias Treier Nature Genetics39, 1018–1024
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review Mining gene expression profiles: expression signatures as cancer phenotypes
Joseph R. Nevins & Anil Potti Nature Reviews Genetics8, 601–609
(August 2007); doi:10.1038/nrg2137
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article A functional role for EGFR signaling in myelination and remyelination
Adan Aguirre, Jeff L Dupree, J M Mangin & Vittorio Gallo Nature Neuroscience10, 990–1002
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article Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
Danielle L Graham, Scott Edwards, Ryan K Bachtell, Ralph J DiLeone, Maribel Rios & David W Self Nature Neuroscience10, 1029–1037
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news and views A role for BDNF in cocaine reward and relapse
Geoffrey Schoenbaum, Thomas A Stalnaker & Yavin Shaham Nature Neuroscience10, 935–936
(August 2007); doi:10.1038/nn0807-935
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article Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Charles W Pemble IV, Lynnette C Johnson, Steven J Kridel & W Todd Lowther Nature Structural & Molecular Biology14, 704–709
(August 2007); doi:10.1038/nsmb1265
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article Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
Gordon Robertson, Martin Hirst, Matthew Bainbridge, Misha Bilenky, Yongjun Zhao, Thomas Zeng, Ghia Euskirchen, Bridget Bernier, Richard Varhol, Allen Delaney, Nina Thiessen, Obi L Griffith, Ann He, Marco Marra, Michael Snyder & Steven Jones Nature Methods4, 651–657
(August 2007); doi:10.1038/nmeth1068
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news and views ChIP-seq: welcome to the new frontier
Elaine R Mardis Nature Methods4, 613–614
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scientific report RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer–TRBP complex
Yukio Kawahara, Boris Zinshteyn, Thimmaiah P Chendrimada, Ramin Shiekhattar & Kazuko Nishikura EMBO Reports8, 763–769
(August 2007); doi:10.1038/sj.embor.7401011
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article Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Tarjei S. Mikkelsen, Manching Ku, David B. Jaffe, Biju Issac, Erez Lieberman, Georgia Giannoukos, Pablo Alvarez, William Brockman, Tae-Kyung Kim, Richard P. Koche, William Lee, Eric Mendenhall, Aisling O'Donovan, Aviva Presser, Carsten Russ, Xiaohui Xie, Alexander Meissner, Marius Wernig, Rudolf Jaenisch, Chad Nusbaum, Eric S. Lander & Bradley E. Bernstein Nature448, 553–560
(2 August 2007); doi:10.1038/nature06008
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letter Common effector processing mediates cell-specific responses to stimuli
Kathryn Miller-Jensen, Kevin A. Janes, Joan S. Brugge & Douglas A. Lauffenburger Nature448, 604–608
(2 August 2007); doi:10.1038/nature06001
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article Exocytotic catecholamine release is not associated with cation flux through channels in the vesicle membrane but Na+ influx through the fusion pore
Liang-Wei Gong, Guillermo Alvarez de Toledo & Manfred Lindau Nature Cell Biology9, 915–922
(August 2007); doi:10.1038/ncb1617
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article A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration
Menachem Katz, Ido Amit, Ami Citri, Tal Shay, Silvia Carvalho, Sara Lavi, Fernanda Milanezi, Ljuba Lyass, Ninette Amariglio, Jasmine Jacob-Hirsch, Nir Ben-Chetrit, Gabi Tarcic, Moshit Lindzen, Roi Avraham, Yi-Chun Liao, Patricia Trusk, Asya Lyass, Gideon Rechavi, Neil L. Spector, Su Hao Lo, Fernando Schmitt, Sarah S. Bacus & Yosef Yarden Nature Cell Biology9, 961–969
(August 2007); doi:10.1038/ncb1622
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news and views Tensin relief facilitates migration
Yuliya Pylayeva & Filippo G. Giancotti Nature Cell Biology9, 877–879
(August 2007); doi:10.1038/ncb0807-877
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news and views GAPDH and the search for alternative energy
Shiwei Song & Toren Finkel Nature Cell Biology9, 869–870
(August 2007); doi:10.1038/ncb0807-869
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review Pathways of clathrin-independent endocytosis
Satyajit Mayor & Richard E. Pagano Nature Reviews Molecular Cell Biology8, 603–612
(August 2007); doi:10.1038/nrm2216
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perspective What's taking so long? S-phase entry from quiescence versus proliferation
Hilary A. Coller Nature Reviews Molecular Cell Biology8, 667–670
(August 2007); doi:10.1038/nrm2223
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article Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
Tom Taghon, Mary A Yui & Ellen V Rothenberg Nature Immunology8, 845–855
(August 2007); doi:10.1038/ni1486
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news and views No DL1 Notch ligand? GATA be a mast cell
Susan Winandy & Melissa Brown Nature Immunology8, 796–797
(August 2007); doi:10.1038/ni0807-796
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review CD3-specific antibodies: a portal to the treatment of autoimmunity
Lucienne Chatenoud & Jeffrey A. Bluestone Nature Reviews Immunology7, 622–632
(August 2007); doi:10.1038/nri2134
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review Molecular mechanisms of alcohol-mediated carcinogenesis
Helmut K. Seitz & Felix Stickel Nature Reviews Cancer7, 599–612
(August 2007); doi:10.1038/nrc2191
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brief communication Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Cristina Sobacchi, Annalisa Frattini, Matteo M Guerrini, Mario Abinun, Alessandra Pangrazio, Lucia Susani, Robbert Bredius, Grazia Mancini, Andrew Cant, Nick Bishop, Peter Grabowski, Andrea Del Fattore, Chiara Messina, Gabriella Errigo, Fraser P Coxon, Debbie I Scott, Anna Teti, Michael J Rogers, Paolo Vezzoni, Anna Villa & Miep H Helfrich Nature Genetics39, 960–962
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brief communication Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai–Barrow and facio–oculo–acoustico–renal syndromes
Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi, Maria Loscertales, Caroline Robson, Tianming Liu, David T MacLaughlin, Kristin M Noonan, Meaghan K Russell, Christopher A Walsh, Patricia K Donahoe & Barbara R Pober Nature Genetics39, 957–959
(August 2007); doi:10.1038/ng2063
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article Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 Å resolution
Cosma D Dellisanti, Yun Yao, James C Stroud, Zuo-Zhong Wang & Lin Chen Nature Neuroscience10, 953–962
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news and views Nicotinic receptor structure emerging slowly
Titia K Sixma Nature Neuroscience10, 937–938
(August 2007); doi:10.1038/nn0807-937
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review Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Csaba Szabó, Harry Ischiropoulos & Rafael Radi Nature Reviews Drug Discovery6, 662–680
(August 2007); doi:10.1038/nrd2222
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article CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices
Jennifer M R Baker, Rhea P Hudson, Voula Kanelis, Wing-Yiu Choy, Patrick H Thibodeau, Philip J Thomas & Julie D Forman-Kay Nature Structural & Molecular Biology14, 738–745
(August 2007); doi:10.1038/nsmb1278
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article Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping
Vanessa Vermeirssen, Bart Deplancke, M Inmaculada Barrasa, John S Reece-Hoyes, H Efsun Arda, Christian A Grove, Natalia J Martinez, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael R Brent & Albertha J M Walhout Nature Methods4, 659–664
(August 2007); doi:10.1038/nmeth1063
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perspective Image-based chemical screening
Anne E Carpenter Nature Chemical Biology3, 461–465
(August 2007); doi:10.1038/nchembio.2007.15
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commentary Reporting data from high-throughput screening of small-molecule libraries
James Inglese, Caroline E Shamu & R Kiplin Guy Nature Chemical Biology3, 438–441
(August 2007); doi:10.1038/nchembio0807-438
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review High-throughput screening assays for the identification of chemical probes
James Inglese, Ronald L Johnson, Anton Simeonov, Menghang Xia, Wei Zheng, Christopher P Austin & Douglas S Auld Nature Chemical Biology3, 466–479
(August 2007); doi:10.1038/nchembio.2007.17
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