The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
letter Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
César Cobaleda, Wolfram Jochum & Meinrad Busslinger Nature449, 473–477
(27 September 2007); doi:10.1038/nature06159
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news and views Immunology: Changed destiny
Huafeng Xie & Stuart H. Orkin Nature449, 410–411
(27 September 2007); doi:10.1038/449410a
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letter Rag mutations reveal robust alternative end joining
Barbara Corneo, Rebecca L. Wendland, Ludovic Deriano, Xiaoping Cui, Isaac A. Klein, Serre-Yu Wong, Suzzette Arnal, Abigail J. Holub, Geoffrey R. Weller, Bette A. Pancake, Sundeep Shah, Vicky L. Brandt, Katheryn Meek & David B. Roth Nature449, 483–486
(27 September 2007); doi:10.1038/nature06168
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letter IgH class switching and translocations use a robust non-classical end-joining pathway
Catherine T. Yan, Cristian Boboila, Ellen Kris Souza, Sonia Franco, Thomas R. Hickernell, Michael Murphy, Sunil Gumaste, Mark Geyer, Ali A. Zarrin, John P. Manis, Klaus Rajewsky & Frederick W. Alt Nature449, 478–482
(27 September 2007); doi:10.1038/nature06020
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letter Structural basis of Dscam isoform specificity
Rob Meijers, Roland Puettmann-Holgado, Georgios Skiniotis, Jin-huan Liu, Thomas Walz, Jia-huai Wang & Dietmar Schmucker Nature449, 487–491
(27 September 2007); doi:10.1038/nature06147
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letter Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
Gabriele A. Amodeo, Michael J. Rudolph & Liang Tong Nature449, 492–495
(27 September 2007); doi:10.1038/nature06127
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letter Structural basis for AMP binding to mammalian AMP-activated protein kinase
Bing Xiao, Richard Heath, Peter Saiu, Fiona C. Leiper, Philippe Leone, Chun Jing, Philip A. Walker, Lesley Haire, John F. Eccleston, Colin T. Davis, Stephen R. Martin, David Carling & Steven J. Gamblin Nature449, 496–500
(27 September 2007); doi:10.1038/nature06161
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brief communication A concentration-dependent switch in the bacterial response to temperature
Hanna Salman & Albert Libchaber Nature Cell Biology9, 1098–1100
(September 2007); doi:10.1038/ncb1632
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news and views Turning to the cold
Victor Sourjik & Ned S. Wingreen Nature Cell Biology9, 1029–1031
(September 2007); doi:10.1038/ncb0907-1029
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review Cell polarity in development and cancer
Andreas Wodarz & Inke Näthke Nature Cell Biology9, 1016–1024
(September 2007); doi:10.1038/ncb433
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perspective Convergent extension and the hexahedral cell
Jeremy B. A. Green & Lance A. Davidson Nature Cell Biology9, 1010–1015
(September 2007); doi:10.1038/ncb438
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article Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex
Bryan Serrels, Alan Serrels, Valerie G. Brunton, Mark Holt, Gordon W. McLean, Christopher H. Gray, Gareth E. Jones & Margaret C. Frame Nature Cell Biology9, 1046–1056
(September 2007); doi:10.1038/ncb1626
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review How stem cells age and why this makes us grow old
Norman E. Sharpless & Ronald A. DePinho Nature Reviews Molecular Cell Biology8, 703–713
(September 2007); doi:10.1038/nrm2241
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perspective Cancer and ageing: convergent and divergent mechanisms
Manuel Serrano & Maria A. Blasco Nature Reviews Molecular Cell Biology8, 715–722
(September 2007); doi:10.1038/nrm2242
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article IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Liang Zhou, Ivaylo I Ivanov, Rosanne Spolski, Roy Min, Kevin Shenderov, Takeshi Egawa, David E Levy, Warren J Leonard & Dan R Littman Nature Immunology8, 967–974
(September 2007); doi:10.1038/ni1488
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review Multiple sclerosis: a complicated picture of autoimmunity
Henry F McFarland & Roland Martin Nature Immunology8, 913–919
(September 2007); doi:10.1038/ni1507
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review Developmental pathways that generate natural-killer-cell diversity in mice and humans
Nicholas D. Huntington, Christian A. J. Vosshenrich & James P. Di Santo Nature Reviews Immunology7, 703–714
(September 2007); doi:10.1038/nri2154
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review Sonic hedgehog signalling in T-cell development and activation
Tessa Crompton, Susan V. Outram & Ariadne L. Hager-Theodorides Nature Reviews Immunology7, 726–735
(September 2007); doi:10.1038/nri2151
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perspective Promiscuity and the single receptor: NKG2D
Robert A. Eagle & John Trowsdale Nature Reviews Immunology7, 737–744
(September 2007); doi:10.1038/nri2144
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review Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
Stephen D. Miller, Danielle M. Turley & Joseph R. Podojil Nature Reviews Immunology7, 665–677
(September 2007); doi:10.1038/nri2153
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article Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Klaus W Wagner, Elizabeth A Punnoose, Thomas Januario, David A Lawrence, Robert M Pitti, Kate Lancaster, Dori Lee, Melissa von Goetz, Sharon Fong Yee, Klara Totpal, Ling Huw, Viswanatham Katta, Guy Cavet, Sarah G Hymowitz, Lukas Amler & Avi Ashkenazi Nature Medicine13, 1070–1077
(September 2007); doi:10.1038/nm1627
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article Lack of Fas antagonism by Met in human fatty liver disease
Chunbin Zou, Jihong Ma, Xue Wang, Lida Guo, Zhenqi Zhu, John Stoops, Amanda E Eaker, Carla J Johnson, Stephen Strom, George K Michalopoulos, Marie C DeFrances & Reza Zarnegar Nature Medicine13, 1078–1085
(September 2007); doi:10.1038/nm1625
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letter High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Toshihiko Tanno, Natarajan V Bhanu, Patricia A Oneal, Sung-Ho Goh, Pamela Staker, Y Terry Lee, John W Moroney, Christopher H Reed, Naomi LC Luban, Rui-Hong Wang, Thomas E Eling, Richard Childs, Tomas Ganz, Susan F Leitman, Suthat Fucharoen & Jeffery L Miller Nature Medicine13, 1096–1101
(September 2007); doi:10.1038/nm1629
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news and views Diseased red blood cells topple iron balance
Stella T Chou & Mitchell J Weiss Nature Medicine13, 1020–1021
(September 2007); doi:10.1038/nm0907-1020
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letter Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Boris V Andreev, Alla S Avedisova, Leonid M Bardenstein, Issak Y Gurovich, Margarita A Morozova, Sergey N Mosolov, Nikolai G Neznanov, Alexander M Reznik, Anatoly B Smulevich, Vladimir A Tochilov, Bryan G Johnson, James A Monn & Darryle D Schoepp Nature Medicine13, 1102–1107
(September 2007); doi:10.1038/nm1632
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news and views Schizophrenia drug says goodbye to dopamine
Daniel R Weinberger Nature Medicine13, 1018–1019
(September 2007); doi:10.1038/nm0907-1018
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technical report A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist
Ian R Wilkinson, Eric Ferrandis, Peter J Artymiuk, Marc Teillot, Chantal Soulard, Caroline Touvay, Sarbendra L Pradhananga, Sue Justice, Zida Wu, Kin C Leung, Christian J Strasburger, Jon R Sayers & Richard J Ross Nature Medicine13, 1108–1113
(September 2007); doi:10.1038/nm1610
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review Modelling breast cancer: one size does not fit all
Tracy Vargo-Gogola & Jeffrey M. Rosen Nature Reviews Cancer7, 659–672
(September 2007); doi:10.1038/nrc2193
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perspective Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state
Kelly A. Green & Jason S. Carroll Nature Reviews Cancer7, 713–722
(September 2007); doi:10.1038/nrc2211
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article Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Christopher E Lowe, Jason D Cooper, Todd Brusko, Neil M Walker, Deborah J Smyth, Rebecca Bailey, Kirsi Bourget, Vincent Plagnol, Sarah Field, Mark Atkinson, David G Clayton, Linda S Wicker & John A Todd Nature Genetics39, 1074–1082
(September 2007); doi:10.1038/ng2102
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article Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
Paul J Norman, Laurent Abi-Rached, Ketevan Gendzekhadze, Daniel Korbel, Michael Gleimer, Don Rowley, Dan Bruno, Christine V F Carrington, Dasdayanee Chandanayingyong, Yih-Hsin Chang, Catalina Crespí, Güher Saruhan-Direskeneli, Patricia A Fraser, Kamran Hameed, Giorgi Kamkamidze, Kwadwo A Koram, Zulay Layrisse, Nuria Matamoros, Joan Milà, Myoung Hee Park, Ramasamy M Pitchappan, D Dan Ramdath, Ming-Yuh Shiau, Henry A F Stephens, Siske Struik, David H Verity, Robert W Vaughan, Dolly Tyan, Ronald W Davis, Eleanor M Riley, Mostafa Ronaghi & Peter Parham Nature Genetics39, 1092–1099
(September 2007); doi:10.1038/ng2111
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review The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
Markus Affolter & Konrad Basler Nature Reviews Genetics8, 663–674
(September 2007); doi:10.1038/nrg2166
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review Integrating physical and genetic maps: from genomes to interaction networks
Andreas Beyer, Sourav Bandyopadhyay & Trey Ideker Nature Reviews Genetics8, 699–710
(September 2007); doi:10.1038/nrg2144
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review Translation matters: protein synthesis defects in inherited disease
Gert C. Scheper, Marjo S. van der Knaap & Christopher G. Proud Nature Reviews Genetics8, 711–723
(September 2007); doi:10.1038/nrg2142
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article A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex
Ryan Remedios, Dhananjay Huilgol, Bhaskar Saha, Padmanabhan Hari, Lahar Bhatnagar, Thomas Kowalczyk, Robert F Hevner, Yoko Suda, Shinichi Aizawa, Toshio Ohshima, Anastassia Stoykova & Shubha Tole Nature Neuroscience10, 1141–1150
(September 2007); doi:10.1038/nn1955
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news and views Amygdala and neocortex: common origins and shared mechanisms
Jan M Deussing & Wolfgang Wurst Nature Neuroscience10, 1081–1082
(September 2007); doi:10.1038/nn0907-1081
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article OL-protocadherin is essential for growth of striatal axons and thalamocortical projections
Masato Uemura, Shinsuke Nakao, Shintaro T Suzuki, Masatoshi Takeichi & Shinji Hirano Nature Neuroscience10, 1151–1159
(September 2007); doi:10.1038/nn1960
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brief communication Cell type-specific gating of perisomatic inhibition by cholecystokinin
Csaba Földy, Soo Yeun Lee, János Szabadics, Axel Neu & Ivan Soltesz Nature Neuroscience10, 1128–1130
(September 2007); doi:10.1038/nn1952
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brief communication EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
Michael Lazarus, Kyoko Yoshida, Roberto Coppari, Caroline E Bass, Takatoshi Mochizuki, Bradford B Lowell & Clifford B Saper Nature Neuroscience10, 1131–1133
(September 2007); doi:10.1038/nn1949
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perspective New insights into BDNF function in depression and anxiety
Keri Martinowich, Husseini Manji & Bai Lu Nature Neuroscience10, 1089–1093
(September 2007); doi:10.1038/nn1971
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review Long-term synaptic plasticity in hippocampal interneurons
Dimitri M. Kullmann & Karri P. Lamsa Nature Reviews Neuroscience8, 687–699
(September 2007); doi:10.1038/nrn2207
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article Prospective identification of myogenic endothelial cells in human skeletal muscle
Bo Zheng, Baohong Cao, Mihaela Crisan, Bin Sun, Guangheng Li, Alison Logar, Solomon Yap, Jonathan B Pollett, Lauren Drowley, Theresa Cassino, Burhan Gharaibeh, Bridget M Deasy, Johnny Huard & Bruno Péault Nature Biotechnology25, 1025–1034
(September 2007); doi:10.1038/nbt1334
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news and views On the iTRAQ of kinase inhibitors
Forest M White Nature Biotechnology25, 994–996
(September 2007); doi:10.1038/nbt0907-994
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brief communication YY1 functions with INO80 to activate transcription
Yong Cai, Jingji Jin, Tingting Yao, Aaron J Gottschalk, Selene K Swanson, Su Wu, Yang Shi, Michael P Washburn, Laurence Florens, Ronald C Conaway & Joan W Conaway Nature Structural & Molecular Biology14, 872–874
(September 2007); doi:10.1038/nsmb1276
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news and views Chloride finds its place in the transport cycle
Susan G Amara Nature Structural & Molecular Biology14, 792–794
(September 2007); doi:10.1038/nsmb0907-792
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review Beyond toothpicks: new methods for isolating mutant bacteria
A. James Link, Ki Jun Jeong & George Georgiou Nature Reviews Microbiology5, 680–688
(September 2007); doi:10.1038/nrmicro1715
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perspective The biological role of death and lysis in biofilm development
Kenneth W. Bayles Nature Reviews Microbiology5, 721–726
(September 2007); doi:10.1038/nrmicro1743
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article An HSV vector system for selection of ligand-gated ion channel modulators
Rahul Srinivasan, Shaohua Huang, Suchita Chaudhry, Adrian Sculptoreanu, David Krisky, Michael Cascio, Peter A Friedman, William C de Groat, Darren Wolfe & Joseph C Glorioso Nature Methods4, 733–739
(September 2007); doi:10.1038/nmeth1077
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news and views Channeling the worm: microfluidic devices for nematode neurobiology
Shawn Lockery Nature Methods4, 691–692
(September 2007); doi:10.1038/nmeth0907-691
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perspective Solution NMR of supramolecular complexes: providing new insights into function
Remco Sprangers, Algirdas Velyvis & Lewis E Kay Nature Methods4, 697–703
(September 2007); doi:10.1038/nmeth1080
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article Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi & Minoru Yoshida Nature Chemical Biology3, 576–583
(September 2007); doi:10.1038/nchembio.2007.18
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letter Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake, Koji Sagane, Takashi Owa, Yuko Mimori-Kiyosue, Hajime Shimizu, Mai Uesugi, Yasushi Ishihama, Masao Iwata & Yoshiharu Mizui Nature Chemical Biology3, 570–575
(September 2007); doi:10.1038/nchembio.2007.16
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news and views Targeting the spliceosome
Brian Rymond Nature Chemical Biology3, 533–535
(September 2007); doi:10.1038/nchembio0907-533
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article Structural insight into filament formation by mammalian septins
Minhajuddin Sirajuddin, Marian Farkasovsky, Florian Hauer, Dorothee Kühlmann, Ian G. Macara, Michael Weyand, Holger Stark & Alfred Wittinghofer Nature449, 410–315
(20 September 2007); doi:10.1038/nature06052
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letter Calcineurin is required to release Xenopus egg extracts from meiotic M phase
Satoru Mochida & Tim Hunt Nature449, 336–340
(20 September 2007); doi:10.1038/nature06121
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letter Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis
Tomoko Nishiyama, Norio Yoshizaki, Takeo Kishimoto & Keita Ohsumi Nature449, 341–345
(20 September 2007); doi:10.1038/nature06136
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news and views Fertilization: Calcium's double punch
Catherine Jessus & Olivier Haccard Nature449, 297–298
(20 September 2007); doi:10.1038/449297a
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letter Generation of functional multipotent adult stem cells from GPR125+ germline progenitors
Marco Seandel, Daylon James, Sergey V. Shmelkov, Ilaria Falciatori, Jiyeon Kim, Sai Chavala, Douglas S. Scherr, Fan Zhang, Richard Torres, Nicholas W. Gale, George D. Yancopoulos, Andrew Murphy, David M. Valenzuela, Robin M. Hobbs, Pier Paolo Pandolfi & Shahin Rafii Nature449, 346–350
(20 September 2007); doi:10.1038/nature06129
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letter Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
Ken-ichi Mizutani, Keejung Yoon, Louis Dang, Akinori Tokunaga & Nicholas Gaiano Nature449, 351–355
(20 September 2007); doi:10.1038/nature06090
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letter Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
Mark A. Travis, Boris Reizis, Andrew C. Melton, Emma Masteller, Qizhi Tang, John M. Proctor, Yanli Wang, Xin Bernstein, Xiaozhu Huang, Louis F. Reichardt, Jeffrey A. Bluestone & Dean Sheppard Nature449, 361–365
(20 September 2007); doi:10.1038/nature06110
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letter Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
Renaud Dentin, Yi Liu, Seung-Hoi Koo, Susan Hedrick, Thomas Vargas, Jose Heredia, John Yates, III & Marc Montminy Nature449, 366–369
(20 September 2007); doi:10.1038/nature06128
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letter Toll-like receptors modulate adult hippocampal neurogenesis
Asya Rolls, Ravid Shechter, Anat London, Yaniv Ziv, Ayal Ronen, Rinat Levy & Michal Schwartz Nature Cell Biology9, 1081–1088
(September 2007); doi:10.1038/ncb1629
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news and views Neural stem cells: guardians of the brain
Gianvito Martino & Stefano Pluchino Nature Cell Biology9, 1031–1034
(September 2007); doi:10.1038/ncb0907-1031
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perspective Differentiation plasticity regulated by TGF-β family proteins in development and disease
Rik Derynck & Rosemary J. Akhurst Nature Cell Biology9, 1000–1004
(September 2007); doi:10.1038/ncb434
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perspective Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
Marco Giorgio, Mirella Trinei, Enrica Migliaccio & Pier Giuseppe Pelicci Nature Reviews Molecular Cell Biology8, 722–728
(September 2007); doi:10.1038/nrm2240
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article Development, cytokine profile and function of human interleukin 17-producing helper T cells
Nicholas J Wilson, Katia Boniface, Jason R Chan, Brent S McKenzie, Wendy M Blumenschein, Jeanine D Mattson, Beth Basham, Kathleen Smith, Taiying Chen, Franck Morel, Jean-Claude Lecron, Robert A Kastelein, Daniel J Cua, Terrill K McClanahan, Edward P Bowman & Rene de Waal Malefyt Nature Immunology8, 950–957
(September 2007); doi:10.1038/ni1497
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article Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
Eva V Acosta-Rodriguez, Giorgio Napolitani, Antonio Lanzavecchia & Federica Sallusto Nature Immunology8, 942–949
(September 2007); doi:10.1038/ni1496
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article The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
Anne Brüstle, Sylvia Heink, Magdalena Huber, Christine Rosenplänter, Christine Stadelmann, Philipp Yu, Enrico Arpaia, Tak W Mak, Thomas Kamradt & Michael Lohoff Nature Immunology8, 958–966
(September 2007); doi:10.1038/ni1500
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news and views TH-17 differentiation: of mice and men
Arian Laurence & John J O'Shea Nature Immunology8, 903–905
(September 2007); doi:10.1038/ni0907-903
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article The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
Liyong Zhang, Michael S Anglesio, Maureen O'Sullivan, Fan Zhang, Ge Yang, Renu Sarao, Mai P Nghiem, Shane Cronin, Hiromitsu Hara, Nataliya Melnyk, Liheng Li, Teiji Wada, Peter P Liu, Jason Farrar, Robert J Arceci, Poul H Sorensen & Josef M Penninger Nature Medicine13, 1060–1069
(September 2007); doi:10.1038/nm1621
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review Maximizing mouse cancer models
Kristopher K. Frese & David A. Tuveson Nature Reviews Cancer7, 654–658
(September 2007); doi:10.1038/nrc2192
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letter Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
Anne-Sophie Nicot, Anne Toussaint, Valérie Tosch, Christine Kretz, Carina Wallgren-Pettersson, Erik Iwarsson, Helen Kingston, Jean-Marie Garnier, Valérie Biancalana, Anders Oldfors, Jean-Louis Mandel & Jocelyn Laporte Nature Genetics39, 1134–1139
(September 2007); doi:10.1038/ng2086
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article Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff, Dirk Eberhard, Yann Abraham, Sonja Bastuck, Markus Boesche, Scott Hobson, Toby Mathieson, Jessica Perrin, Manfred Raida, Christina Rau, Valérie Reader, Gavain Sweetman, Andreas Bauer, Tewis Bouwmeester, Carsten Hopf, Ulrich Kruse, Gitte Neubauer, Nigel Ramsden, Jens Rick, Bernhard Kuster & Gerard Drewes Nature Biotechnology25, 1035–1044
(September 2007); doi:10.1038/nbt1328
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review Molecular basis for sunitinib efficacy and future clinical development
Sandrine Faivre, George Demetri, William Sargent & Eric Raymond Nature Reviews Drug Discovery6, 734–745
(September 2007); doi:10.1038/nrd2380
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article Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
Natalia Mitin, Laurie Betts, Marielle E Yohe, Channing J Der, John Sondek & Kent L Rossman Nature Structural & Molecular Biology14, 814–823
(September 2007); doi:10.1038/nsmb1290
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article MicroRNA control of Nodal signalling
Graziano Martello, Luca Zacchigna, Masafumi Inui, Marco Montagner, Maddalena Adorno, Anant Mamidi, Leonardo Morsut, Sandra Soligo, Uyen Tran, Sirio Dupont, Michelangelo Cordenonsi, Oliver Wessely & Stefano Piccolo Nature449, 183–188
(13 September 2007); doi:10.1038/nature06100
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letter Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Laura E. Parton, Chian Ping Ye, Roberto Coppari, Pablo J. Enriori, Brian Choi, Chen-Yu Zhang, Chun Xu, Claudia R. Vianna, Nina Balthasar, Charlotte E. Lee, Joel K. Elmquist, Michael A. Cowley & Bradford B. Lowell Nature449, 228–232
(13 September 2007); doi:10.1038/nature06098
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letter The structural basis for activation of plant immunity by bacterial effector protein AvrPto
Weiman Xing, Yan Zou, Qun Liu, Jianing Liu, Xi Luo, Qingqiu Huang, She Chen, Lihuang Zhu, Ruchang Bi, Quan Hao, Jia-Wei Wu, Jian-Min Zhou & Jijie Chai Nature449, 243–247
(13 September 2007); doi:10.1038/nature06109
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letter Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic
Zita Balklava, Saumya Pant, Hanna Fares & Barth D. Grant Nature Cell Biology9, 1066–1073
(2007); doi:10.1038/ncb1627
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news and views PARtners for endocytosis
Frédéric Wissler & Michel Labouesse Nature Cell Biology9, 1027–1029
(2007); doi:10.1038/ncb0907-1027
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review The role of nuclear architecture in genomic instability and ageing
Philipp Oberdoerffer & David A. Sinclair Nature Reviews Molecular Cell Biology8, 692–702
(September 2007); doi:10.1038/nrm2238
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review Self-eating and self-killing: crosstalk between autophagy and apoptosis
M. Chiara Maiuri, Einat Zalckvar, Adi Kimchi & Guido Kroemer Nature Reviews Molecular Cell Biology8, 741–752
(September 2007); doi:10.1038/nrm2239
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article Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Dan Feng, Christopher J Bond, Lauren K Ely, Jennifer Maynard & K Christopher Garcia Nature Immunology8, 975–983
(2007); doi:10.1038/ni1502
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article MALT1 directs B cell receptor-induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit
Uta Ferch, Christian Meyer zum Büschenfelde, Andreas Gewies, Elmar Wegener, Sandra Rauser, Christian Peschel, Daniel Krappmann & Jürgen Ruland Nature Immunology8, 984–991
(2007); doi:10.1038/ni1493
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review Getting to the site of inflammation: the leukocyte adhesion cascade updated
Klaus Ley, Carlo Laudanna, Myron I. Cybulsky & Sussan Nourshargh Nature Reviews Immunology7, 678–689
(September 2007); doi:10.1038/nri2156
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article Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Lionel Apetoh, François Ghiringhelli, Antoine Tesniere, Michel Obeid, Carla Ortiz, Alfredo Criollo, Grégoire Mignot, M Chiara Maiuri, Evelyn Ullrich, Patrick Saulnier, Huan Yang, Sebastian Amigorena, Bernard Ryffel, Franck J Barrat, Paul Saftig, Francis Levi, Rosette Lidereau, Catherine Nogues, Jean-Paul Mira, Agnès Chompret, Virginie Joulin, Françoise Clavel-Chapelon, Jean Bourhis, Fabrice André, Suzette Delaloge, Thomas Tursz, Guido Kroemer & Laurence Zitvogel Nature Medicine13, 1050–1059
(2007); doi:10.1038/nm1622
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article Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Eugene A Podrez, Tatiana V Byzova, Maria Febbraio, Robert G Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J Finton, Brian R Curtis, Juhua Chen, Renliang Zhang, Roy L Silverstein & Stanley L Hazen Nature Medicine13, 1086–1095
(2007); doi:10.1038/nm1626
| Summary | Full Text (HTML / PDF) |
news and views The clot thickens-oxidized lipids and thrombosis
Shaun P Jackson & Anna C Calkin Nature Medicine13, 1015–1016
(2007); doi:10.1038/nm0907-1015
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news and views Muscle growth learns new tricks from an old dog
Gustavo A Nader Nature Medicine13, 1016–1018
(2007); doi:10.1038/nm0907-1016
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technical report Molecular imaging of Akt kinase activity
Limin Zhang, Kuei C Lee, Mahaveer S Bhojani, Amjad P Khan, Alla Shilman, Eric C Holland, Brian D Ross & Alnawaz Rehemtulla Nature Medicine13, 1114–1119
(September 2007); doi:10.1038/nm1608
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review Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
Ross L. Levine, Animesh Pardanani, Ayalew Tefferi & D. Gary Gilliland Nature Reviews Cancer7, 673–683
(September 2007); doi:10.1038/nrc2210
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letter Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype
Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean-Pierre Fryns, Jan Cools, Peter Marynen, Gilles Thomas, Akihiko Yoshimura & Eric Legius Nature Genetics39, 1120–1126
(2007); doi:10.1038/ng2113
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article Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
Krisztina Foltenyi, Ralph J Greenspan & John W Newport Nature Neuroscience10, 1160–1167
(2007); doi:10.1038/nn1957
| Summary | Full Text (HTML / PDF) |
news and views Soporific signaling: how flies sleep through the night
Christopher S Colwell Nature Neuroscience10, 1079–1080
(2007); doi:10.1038/nn0907-1079
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review The effect of neurodegenerative diseases on the subventricular zone
Maurice A. Curtis, Richard L. M. Faull & Peter S. Eriksson Nature Reviews Neuroscience8, 712–723
(September 2007); doi:10.1038/nrn2216
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letter A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean-Pierre Yougen Li, D Allan Drummond, Andrew M Sawayama, Christopher D Snow, Jesse D Bloom & Frances H Arnold Nature Biotechnology25, 1051–1056
(2007); doi:10.1038/nbt1333
| Summary | Full Text (HTML / PDF) |
analysis Ensemble modeling for analysis of cell signaling dynamics
Lars Kuepfer, Matthias Peter, Uwe Sauer & Jörg Stelling Nature Biotechnology25, 1001–1006
(2007); doi:10.1038/nbt1330
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article MRE11—RAD50—NBS1 and ATM function as co-mediators of TRF1 in telomere length control
Yili Wu, Shujie Xiao & Xu-Dong Zhu Nature Structural & Molecular Biology14, 832–840
(2007); doi:10.1038/nsmb1286
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article Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells
Pierre-Alain Girod, Duc-Quang Nguyen, David Calabrese, Stefania Puttini, Mélanie Grandjean, Danielle Martinet, Alexandre Regamey, Damien Saugy, Jacques S Beckmann, Philipp Bucher & Nicolas Mermod Nature Methods4, 747–753
(2007); doi:10.1038/nmeth1076
| Summary | Full Text (HTML / PDF) |
review Targeting virulence: a new paradigm for antimicrobial therapy
Anne E Clatworthy, Emily Pierson & Deborah T Hung Nature Chemical Biology3, 541–548
(September 2007); doi:10.1038/nchembio.2007.24
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article Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide
Giovanni D'Angelo, Elena Polishchuk, Giuseppe Di Tullio, Michele Santoro, Antonella Di Campli, Anna Godi, Gun West, Jacek Bielawski, Chia-Chen Chuang, Aarnoud C. van der Spoel, Frances M. Platt, Yusuf A. Hannun, Roman Polishchuk, Peter Mattjus & Maria Antonietta De Matteis Nature449, 62–67
(6 September 2007); doi:10.1038/nature06097
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news and views Cell biology: Taxi service for lipids
Anthony H. Futerman Nature449, 35–37
(6 September 2007); doi:10.1038/449035a
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letter Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells
Piotr Kazmierczak, Hirofumi Sakaguchi, Joshua Tokita, Elizabeth M. Wilson-Kubalek, Ronald A. Milligan, Ulrich Müller & Bechara Kachar Nature449, 87–91
(6 September 2007); doi:10.1038/nature06091
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letter Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
Hongyan Wang, Yingshi Ouyang, W. Gregory Somers, William Chia & Bingwei Lu Nature449, 96–100
(6 September 2007); doi:10.1038/nature06056
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letter p53 is regulated by the lysine demethylase LSD1
Jing Huang, Roopsha Sengupta, Alexsandra B. Espejo, Min Gyu Lee, Jean A. Dorsey, Mario Richter, Susanne Opravil, Ramin Shiekhattar, Mark T. Bedford, Thomas Jenuwein & Shelley L. Berger Nature449, 105–108
(6 September 2007); doi:10.1038/nature06092
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article S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction
Heike Stroissnigg, Alzbeta Trancíková, Luise Descovich, Jakob Fuhrmann, Waltraud Kutschera, Julius Kostan, Arabella Meixner, Fatiha Nothias & Friedrich Propst Nature Cell Biology9, 1035–1045
(September 2007); doi:10.1038/ncb1625
| Summary | Full Text (HTML / PDF) |
letter The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun
Ryo Koyama-Nasu, Gregory David & Naoko Tanese Nature Cell Biology9, 1074–1080
(September 2007); doi:10.1038/ncb1628
| Summary | Full Text (HTML / PDF) |
perspective Patching the gaps in Hedgehog signalling
Rajat Rohatgi & Matthew P. Scott Nature Cell Biology9, 1005–1009
(September 2007); doi:10.1038/ncb435
| Summary | Full Text (HTML / PDF) |
review Endocrine regulation of ageing
Steven J. Russell & C. Ronald Kahn Nature Reviews Molecular Cell Biology8, 681–691
(September 2007); doi:10.1038/nrm2234
| Summary | Full Text (HTML / PDF) |
review Cellular senescence: when bad things happen to good cells
Judith Campisi & Fabrizio d'Adda di Fagagna Nature Reviews Molecular Cell Biology8, 729–740
(September 2007); doi:10.1038/nrm2233
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article Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
Craig L Maynard, Laurie E Harrington, Karen M Janowski, James R Oliver, Carlene L Zindl, Alexander Y Rudensky & Casey T Weaver Nature Immunology8, 931–941
(September 2007); doi:10.1038/ni1504
| Summary | Full Text (HTML / PDF) |
news and views Regula'ten' the gut
Paulo Vieira & Anne O'Garra Nature Immunology8, 905–907
(September 2007); doi:10.1038/ni0907-905
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article Crystal structure of the IL-15–IL-15Rα complex, a cytokine-receptor unit presented in trans
Mami Chirifu, Chiharu Hayashi, Teruya Nakamura, Sachiko Toma, Tsuyoshi Shuto, Hirofumi Kai, Yuriko Yamagata, Simon J Davis & Shinji Ikemizu Nature Immunology8, 1001–1007
(September 2007); doi:10.1038/ni1492
| Summary | Full Text (HTML / PDF) |
review Calcium signalling in lymphocyte activation and disease
Stefan Feske Nature Reviews Immunology7, 690–702
(September 2007); doi:10.1038/nri2152
| Summary | Full Text (HTML / PDF) |
review Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Kristin K. Deeb, Donald L. Trump & Candace S. Johnson Nature Reviews Cancer7, 684–700
(September 2007); doi:10.1038/nrc2196
| Summary | Full Text (HTML / PDF) |
perspective Building better magic bullets — improving unconjugated monoclonal antibody therapy for cancer
Louis M. Weiner Nature Reviews Cancer7, 701–706
(September 2007); doi:10.1038/nrc2209
| Summary | Full Text (HTML / PDF) |
letter RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Vivek Shukla, Xavier Coumoul, Rui-Hong Wang, Hyun-Seok Kim & Chu-Xia Deng Nature Genetics39, 1145–1150
(September 2007); doi:10.1038/ng2096
| Summary | Full Text (HTML / PDF) |
news and views Cancer drugs to treat birth defects
Andrew O M Wilkie Nature Genetics39, 1057–1059
(September 2007); doi:10.1038/ng0907-1057
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review Translation matters: protein synthesis defects in inherited disease
Gert C. Scheper, Marjo S. van der Knaap & Christopher G. Proud Nature Reviews Genetics8, 711–723
(September 2007); doi:10.1038/nrg2142
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article Nicotinic control of axon excitability regulates thalamocortical transmission
Hideki Kawai, Ronit Lazar & Raju Metherate Nature Neuroscience10, 1168–1175
(September 2007); doi:10.1038/nn1956
| Summary | Full Text (HTML / PDF) |
brief communication Kinase activity is not required for αCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses
Mohammad Reza Hojjati, Geeske M van Woerden, William J Tyler, Karl Peter Giese, Alcino J Silva, Lucas Pozzo-Miller & Ype Elgersma Nature Neuroscience10, 1125–1127
(September 2007); doi:10.1038/nn1946
| Summary | Full Text (HTML / PDF) |
review Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Jürgen Wess, Richard M. Eglen & Dinesh Gautam Nature Reviews Drug Discovery6, 721–733
(September 2007); doi:10.1038/nrd2379
| Summary | Full Text (HTML / PDF) |
article Structural dynamics in the gating ring of cyclic nucleotide-gated ion channels
Justin W Taraska & William N Zagotta Nature Structural & Molecular Biology14, 854–860
(September 2007); doi:10.1038/nsmb1281
| Summary | Full Text (HTML / PDF) |
news and views When it comes to couple(r)s, do opposites attract?
Sharsti Sandall & Arshad Desai Nature Structural & Molecular Biology14, 790–792
(September 2007); doi:10.1038/nsmb0907-790
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brief communication Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection
Brock A Peters, Zhengyan Kan, Dragan Sebisanovic, Kanan Pujara, Zhiyong Wang, Peter Hong, Bernard Chow, Jeremy Stinson, Victoria E H Carlton, Thinh Q Pham, Howard Stern, Paul Waring, Kenneth J Hillan, David A Eberhard, Frederic de Sauvage, Jianbiao Zheng, Malek Faham & Somasekar Seshagiri Nature Methods4, 713–715
(September 2007); doi:10.1038/nmeth1081
| Summary | Full Text (HTML / PDF) |
perspective Solution NMR of supramolecular complexes: providing new insights into function
Remco Sprangers, Algirdas Velyvis & Lewis E Kay Nature Methods4, 697–703
(September 2007); doi:10.1038/nmeth1080
| Summary | Full Text (HTML / PDF) |
letter Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids
Xiangtian Long, Shenglou Deng, Jochen Mattner, Zhuo Zang, Dapeng Zhou, Nathan McNary, Randal D Goff, Luc Teyton, Albert Bendelac & Paul B Savage Nature Chemical Biology3, 559–564
(September 2007); doi:10.1038/nchembio.2007.19
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scientific report The Arabidopsis TOR kinase links plant growth, yield, stress resistance and mRNA translation
Dorothée Deprost, Lei Yao, Rodnay Sormani, Manon Moreau, Guillaume Leterreux, Maryse Nicolaï, Magali Bedu, Christophe Robaglia & Christian Meyer EMBO Reports8, 864–870
(September 2007); doi:10.1038/nchembio.2007.19
| Summary | Full Text (HTML / PDF) |
