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January 2008
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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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letter
Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina
Masahito Yamagata & Joshua R. Sanes
Nature 451, 465–469
(24 January 2008); doi:10.1038/nature06469
| Summary | Full Text (HTML / PDF) |
letter
Neurite arborization and mosaic spacing in the mouse retina require DSCAM
Peter G. Fuerst, Amane Koizumi, Richard H. Masland & Robert W. Burgess
Nature 451, 470–474
(24 January 2008); doi:10.1038/nature06514
| Summary | Full Text (HTML / PDF) |
letter
Coordinated regulation of Arabidopsisthaliana development by light and gibberellins
Suhua Feng et al.
Nature 451, 475–479
(24 January 2008); doi:10.1038/nature06448
| Summary | Full Text (HTML / PDF) |
letter
A molecular framework for light and gibberellin control of cell elongation
Miguel de Lucas et al.
Nature 451, 480–484
(24 January 2008); doi:10.1038/nature06520
| Summary | Full Text (HTML / PDF) |
news and views
Molecular Biology: The expanding world of small RNAs
Helge Großhans & Witold Filipowicz
Nature 451, 414–416
(24 January 2008); doi:10.1038/451414a
| Full Text (HTML / PDF) |
letter
Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
Kevin C. Corbit, Amy E. Shyer, William E. Dowdle, Julie Gaulden, Veena Singla & Jeremy F. Reiter
Nature Cell Biology 10, 70–76
(January 2008); doi:10.1038/ncb1670
| Summary | Full Text (HTML / PDF) |
news and views
Cilia put a brake on Wnt signalling
Xi He
Nature Cell Biology 10, 11–13
(January 2008); doi:10.1038/ncb0108-11
| Summary | Full Text (HTML / PDF) |
letter
Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis
Daijiro Konno et al.
Nature Cell Biology 10, 93–101
(January 2008); doi:10.1038/ncb1673
| Summary | Full Text (HTML / PDF) |
review
Molecular architecture of the kinetochore–microtubule interface
Iain M. Cheeseman & Arshad Desai
Nature Reviews Molecular Cell Biology 9, 33–46
(January 2008); doi:10.1038/nrm2310
| Summary | Full Text (HTML / PDF) |
article
Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice
Akira Goto et al.
Nature Immunology 9, 97–104
(January 2008); doi:10.1038/ni1543
| Summary | Full Text (HTML / PDF) |
news and views
Akirins versus infection
Bruce Beutler & Eva Marie Y Moresco
Nature Immunology 9, 7–9
(January 2008); doi:10.1038/ni0108-7
| Full Text (HTML / PDF) |
perspective
How microorganisms tip the balance between interleukin-12 family members
Stanislas Goriely, Markus F. Neurath & Michel Goldman
Nature Reviews Immunology 8, 81–86
(January 2008); doi:10.1038/nri2225
| Summary | Full Text (HTML / PDF) |
letter
G12–G13–LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Angela Wirth et al.
Nature Medicine 14, 64–68
(January 2008); doi:10.1038/nm1666
| Summary | Full Text (HTML / PDF) |
news and views
Salt abuse: the path to hypertension
Wilhelm Schoner
Nature Medicine 14, 16–17
(January 2008); doi:10.1038/nm0108-16
| Summary | Full Text (HTML / PDF) |
review
The anaplastic lymphoma kinase in the pathogenesis of cancer
Roberto Chiarle, Claudia Voena, Chiara Ambrogio, Roberto Piva & Giorgio Inghirami
Nature Reviews Cancer 8, 11–23
(January 2008); doi:10.1038/nrc2291
| Summary | Full Text (HTML / PDF) |
article
Widespread microRNA repression by Myc contributes to tumorigenesis
Tsung-Cheng Chang et al.
Nature Genetics 40, 43–50
(January 2008); doi:10.1038/ng.2007.30
| Summary | Full Text (HTML / PDF) |
review
The multifaceted role of Notch in cardiac development and disease
Frances A. High & Jonathan A. Epstein
Nature Reviews Genetics 9, 49–61
(January 2008); doi:10.1038/nrg2279
| Summary | Full Text (HTML / PDF) |
article
Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling
Xiaoling Li, Xue Gao, Guofa Liu, Wencheng Xiong, Jane Wu & Yi Rao
Nature Neuroscience 11, 28–35
(January 2008); doi:10.1038/nn2022
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article
Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo
Erik Henke et al.
Nature Biotechnology 26, 91–100
(January 2008); doi:10.1038/nbt1366
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letter
A quantitative analysis of kinase inhibitor selectivity
Mazen W Karaman et al.
Nature Biotechnology 26, 127–132
(January 2008); doi:10.1038/nbt1358
| Summary | Full Text (HTML / PDF) |
perspective
Protein therapeutics: a summary and pharmacological classification
Benjamin Leader, Quentin J. Baca & David E. Golan
Nature Reviews Drug Discovery 7, 21–39
(January 2008); doi:10.1038/nrd2399
| Summary | Full Text (HTML / PDF) |
article
Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
Xiaoyan Chen, Heli Liu, Ann H R Shim, Pamela J Focia & Xiaolin He
Nature Structural & Molecular Biology 15, 50–56
(January 2008); doi:10.1038/nsmb1350
| Summary | Full Text (HTML / PDF) |
review
Getting organized — how bacterial cells move proteins and DNA
Martin Thanbichler & Lucy Shapiro
Nature Reviews Microbiology 6, 28–40
(January 2008); doi:10.1038/nrmicro1795
| Summary | Full Text (HTML / PDF) |
letter
Reversal of pathological pain through specific spinal GABAA receptor subtypes
Julia Knabl et al.
Nature 451, 330–334
(17 January 2008); doi:10.1038/nature06493
| Summary | Full Text (HTML / PDF) |
letter
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
Maksim V. Plikus et al.
Nature 451, 340–344
(17 January 2008); doi:10.1038/nature06457
| Summary | Full Text (HTML / PDF) |
letter
Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345–349
(17 January 2008); doi:10.1038/nature06489
| Summary | Full Text (HTML / PDF) |
article
Disruption of KIF17–Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin–cargo release
Laurent Guillaud, Richard Wong & Nobutaka Hirokawa
Nature Cell Biology 10, 19–29
(January 2008); doi:10.1038/ncb1665
| Summary | Full Text (HTML / PDF) |
news and views
Motor-cargo release: CaMKII as a traffic cop
Shabeen Ally, Amber L. Jolly & Vladimir I. Gelfand
Nature Cell Biology 10, 3–5
(January 2008); doi:10.1038/ncb0108-3
| Summary | Full Text (HTML / PDF) |
review
Heterotrimeric G protein activation by G-protein-coupled receptors
William M. Oldham & Heidi E. Hamm
Nature Reviews Molecular Cell Biology 9, 60–71
(January 2008); doi:10.1038/nrm2299
| Summary | Full Text (HTML / PDF) |
article
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
Thirumalai R Ramalingam et al.
Nature Immunology 9, 25–33
(January 2008); doi:10.1038/ni1544
| Summary | Full Text (HTML / PDF) |
article
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
Shin-ichi Kano et al.
Nature Immunology 9, 34–41
(January 2008); doi:10.1038/ni1538
| Summary | Full Text (HTML / PDF) |
news and views
IRF1: a deus ex machina in TH1 differentiation
Derya Unutmaz & Jan Vilcek
Nature Immunology 9, 9–10
(January 2008); doi:10.1038/ni0108-9
| Full Text (HTML / PDF) |
review
Fcγ receptors as regulators of immune responses
Falk Nimmerjahn & Jeffrey V. Ravetch
Nature Reviews Immunology 8, 34–47
(January 2008); doi:10.1038/nri2206
| Summary | Full Text (HTML / PDF) |
article
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
Andrew M Tager et al.
Nature Medicine 14, 45–54
(January 2008); doi:10.1038/nm1685
| Summary | Full Text (HTML / PDF) |
news and views
From lung injury to fibrosis
Klaus Ley & Alexander Zarbock
Nature Medicine 14, 20–21
(January 2008); doi:10.1038/nm0108-20
| Summary | Full Text (HTML / PDF) |
perspective
The interplay between MYC and HIF in cancer
Chi V. Dang, Jung-whan Kim, Ping Gao & Jason Yustein
Nature Reviews Cancer 8, 51–56
(January 2008); doi:10.1038/nrc2274
| Summary | Full Text (HTML / PDF) |
letter
AID is required for germinal center-derived lymphomagenesis
Laura Pasqualucci et al.
Nature Genetics 40, 108–112
(January 2008); doi:10.1038/ng.2007.35
| Summary | Full Text (HTML / PDF) |
perspective
The emerging landscape of breast cancer susceptibility
Michael R Stratton & Nazneen Rahman
Nature Genetics 40, 17–22
(January 2008); doi:10.1038/ng.2007.53
| Summary | Full Text (HTML / PDF) |
review
Coupling and coordination in gene expression processes: a systems biology view
Suzanne Komili & Pamela A. Silver
Nature Reviews Genetics 9, 38–48
(January 2008); doi:10.1038/nrg2223
| Summary | Full Text (HTML / PDF) |
review
The expectant brain: adapting for motherhood
Paula J. Brunton & John A. Russell
Nature Reviews Neuroscience 9, 11–25
(January 2008); doi:10.1038/nrn2280
| Summary | Full Text (HTML / PDF) |
letter
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Masato Nakagawa et al.
Nature Biotechnology 26, 101–106
(January 2008); doi:10.1038/nbt1374
| Summary | Full Text (HTML / PDF) |
news and views
Simpler and safer cell reprogramming
Martin F Pera & Kouichi Hasegawa
Nature Biotechnology 26, 59–60
(January 2008); doi:10.1038/nbt0108-59
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase
Jianbo Diao, Ying Zhang, Jon M Huibregtse, Daoguo Zhou & Jue Chen
Nature Structural & Molecular Biology 15, 65–70
(January 2008); doi:10.1038/nsmb1346
| Summary | Full Text (HTML / PDF) |
article
Tracking transmitter-gated P2X cation channel activation in vitro and in vivo
Esther Richler et al.
Nature Methods 5, 87–93
(January 2008); doi:10.1038/nmeth1144
| Summary | Full Text (HTML / PDF) |
news and views
IP7 guards the CDK gate
John D York & Daniel J Lew
Nature Chemical Biology 4, 16–17
(January 2008); doi:10.1038/nchembio0108-16
| Full Text (HTML / PDF) |
article
Reprogramming of human somatic cells to pluripotency with defined factors
In-Hyun Park et al.
Nature 451, 141–146
(10 January 2008); doi:10.1038/nature06534
| Summary | Full Text (HTML / PDF) |
news and views
Stem cells: A new year and a new era
Martin F. Pera
Nature 451, 135–136
(10 January 2008); doi:10.1038/451135a
| Full Text (HTML / PDF) |
article
Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F. Tavazoie et al.
Nature 451, 147–152
(10 January 2008); doi:10.1038/nature06487
| Summary | Full Text (HTML / PDF) |
letter
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu et al.
Nature 451, 202–206
(10 January 2008); doi:10.1038/nature06468
| Summary | Full Text (HTML / PDF) |
letter
Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii
Kisaburo Nagamune, Leslie M. Hicks, Blima Fux, Fabien Brossier, Eduardo N. Chini & L. David Sibley
Nature 451, 207–210
(10 January 2008); doi:10.1038/nature06478
| Summary | Full Text (HTML / PDF) |
letter
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
Masaki Morishige et al.
Nature Cell Biology 10, 85–92
(January 2008); doi:10.1038/ncb1672
| Summary | Full Text (HTML / PDF) |
news and views
Getting invasive with GEP100 and Arf6
Ferran Valderrama & Anne J. Ridley
Nature Cell Biology 10, 16–18
(January 2008); doi:10.1038/ncb0108-16
| Summary | Full Text (HTML / PDF) |
article
ARF1 is directly involved in dynamin-independent endocytosis
Sudha Kumari & Satyajit Mayor
Nature Cell Biology 10, 30–41
(January 2008); doi:10.1038/ncb1666
| Summary | Full Text (HTML / PDF) |
review
Regulation of iron acquisition and storage: consequences for iron-linked disorders
Ivana De Domenico, Diane McVey Ward & Jerry Kaplan
Nature Reviews Molecular Cell Biology 9, 72–81
(January 2008); doi:10.1038/nrm2295
| Summary | Full Text (HTML / PDF) |
article
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
Levi G Ledgerwood et al.
Nature Immunology 9, 42–53
(January 2008); doi:10.1038/ni1534
| Summary | Full Text (HTML / PDF) |
article
CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand
David Depoil et al.
Nature Immunology 9, 63–72
(January 2008); doi:10.1038/ni1547
| Summary | Full Text (HTML / PDF) |
article
Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13
Geetanjali Bansal, Zhihui Xie, Sudhir Rao, Karl H Nocka & Kirk M Druey
Nature Immunology 9, 73–80
(January 2008); doi:10.1038/ni1533
| Summary | Full Text (HTML / PDF) |
review
Launching the T-cell-lineage developmental programme
Ellen V. Rothenberg, Jonathan E. Moore & Mary A. Yui
Nature Reviews Immunology 8, 9–21
(January 2008); doi:10.1038/nri2232
| Summary | Full Text (HTML / PDF) |
article
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
Ronald J Buckanovich et al.
Nature Medicine 14, 28–36
(January 2008); doi:10.1038/nm1699
| Summary | Full Text (HTML / PDF) |
news and views
Opening the gateway to tumors
Michael H Kershaw
Nature Medicine 14, 13–14
(January 2008); doi:10.1038/nm0108-13
| Summary | Full Text (HTML / PDF) |
article
Modification of kidney barrier function by the urokinase receptor
Changli Wei et al.
Nature Medicine 14, 55–63
(January 2008); doi:10.1038/nm1696
| Summary | Full Text (HTML / PDF) |
letter
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
Lao H Saal et al.
Nature Genetics 40, 102–107
(January 2008); doi:10.1038/ng.2007.39
| Summary | Full Text (HTML / PDF) |
news and views
BRCA1—sowing the seeds crooked in the furrow
William D Foulkes
Nature Genetics 40, 8–9
(January 2008); doi:10.1038/ng0108-8
| Full Text (HTML / PDF) |
review
From inflammation to sickness and depression: when the immune system subjugates the brain
Robert Dantzer, Jason C. O'Connor, Gregory G. Freund, Rodney W. Johnson & Keith W. Kelley
Nature Reviews Neuroscience 9, 46–56
(January 2008); doi:10.1038/nrn2297
| Summary | Full Text (HTML / PDF) |
brief communication
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
Margarita Malakhova et al.
Nature Structural & Molecular Biology 15, 112–113
(January 2008); doi:10.1038/nsmb1347
| Summary | Full Text (HTML / PDF) |
news and views
DNA damage: ubiquitin marks the spot
Eric J Bennett & J Wade Harper
Nature Structural & Molecular Biology 15, 20–22
(January 2008); doi:10.1038/nsmb0108-20
| Full Text (HTML / PDF) |
review
An integrated model of the recognition of Candida albicans by the innate immune system
Mihai G. Netea, Gordon D. Brown, Bart Jan Kullberg & Neil A. R. Gow
Nature Reviews Microbiology 6, 67–78
(January 2008); doi:10.1038/nrmicro1815
| Summary | Full Text (HTML / PDF) |
review
Live-cell imaging of cAMP dynamics
Debbie Willoughby & Dermot M F Cooper
Nature Methods 5, 29–36
(January 2008); doi:10.1038/nmeth1135
| Summary | Full Text (HTML / PDF) |
article
Molecular basis of cyclin–CDK–CKI regulation by reversible binding of an inositol pyrophosphate
Young-Sam Lee, Kexin Huang, Florante A Quiocho & Erin K O'Shea
Nature Chemical Biology 4, 25–32
(January 2008); doi:10.1038/nchembio.2007.52
| Summary | Full Text (HTML / PDF) |
article
A receptor that mediates the post-mating switch in Drosophila reproductive behaviour
Nilay Yapici, Young-Joon Kim, Carlos Ribeiro & Barry J. Dickson
Nature 451, 33–37
(3 January 2008); doi:10.1038/nature06483
| Summary | Full Text (HTML / PDF) |
letter
TRPC channel activation by extracellular thioredoxin
Shang-Zhong Xu et al.
Nature 451, 69–72
(3 January 2008); doi:10.1038/nature06414
| Summary | Full Text (HTML / PDF) |
letter
Trisomy represses ApcMin-mediated tumours in mouse models of Down's syndrome
Thomas E. Sussan, Annan Yang, Fu Li, Michael C. Ostrowski & Roger H. Reeves
Nature 451, 73–75
(3 January 2008); doi:10.1038/nature06446
| Summary | Full Text (HTML / PDF) |
letter
NUMB controls p53 tumour suppressor activity
Ivan N. Colaluca et al.
Nature 451, 76–80
(3 January 2008); doi:10.1038/nature06412
| Summary | Full Text (HTML / PDF) |
letter
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Ivan Ahel et al.
Nature 451, 81–85
(3 January 2008); doi:10.1038/nature06420
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
Eric Metzger et al.
Nature Cell Biology 10, 53–60
(January 2008); doi:10.1038/ncb1668
| Summary | Full Text (HTML / PDF) |
news and views
Thrilling transcription through threonine phosphorylation
Luciano Di Croce & Ramin Shiekhattar
Nature Cell Biology 10, 5–6
(January 2008); doi:10.1038/ncb0108-5
| Summary | Full Text (HTML / PDF) |
news and views
Redox rescues virus from ER trap
Christoph J. Burckhardt & Urs F. Greber
Nature Cell Biology 10, 9–11
(January 2008); doi:10.1038/ncb0108-9
| Summary | Full Text (HTML / PDF) |
review
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle & Andreas Strasser
Nature Reviews Molecular Cell Biology 9, 47–59
(January 2008); doi:10.1038/nrm2308
| Summary | Full Text (HTML / PDF) |
article
Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
Yoshihiro Baba, Keigo Nishida, Yoko Fujii, Toshio Hirano, Masaki Hikida & Tomohiro Kurosaki
Nature Immunology 9, 81–88
(January 2008); doi:10.1038/ni1546
| Summary | Full Text (HTML / PDF) |
article
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels
Monika Vig et al.
Nature Immunology 9, 89–96
(January 2008); doi:10.1038/ni1550
| Summary | Full Text (HTML / PDF) |
review
Immunological aspects of cancer chemotherapy
Laurence Zitvogel, Lionel Apetoh, François Ghiringhelli & Guido Kroemer
Nature Reviews Immunology 8, 59–73
(January 2008); doi:10.1038/nri2216
| Summary | Full Text (HTML / PDF) |
perspective
Survivin, cancer networks and pathway-directed drug discovery
Dario C. Altieri
Nature Reviews Cancer 8, 61–70
(January 2008); doi:10.1038/nrc2293
| Summary | Full Text (HTML / PDF) |
article
Ciliary proteins link basal body polarization to planar cell polarity regulation
Chonnettia Jones et al.
Nature Genetics 40, 69–77
(January 2008); doi:10.1038/ng.2007.54
| Summary | Full Text (HTML / PDF) |
news and views
Basal bodies, kinocilia and planar cell polarity
Jeffrey D Axelrod
Nature Genetics 40, 10–11
(January 2008); doi:10.1038/ng0108-10
| Full Text (HTML / PDF) |
article
Semaphorin-3A guides radial migration of cortical neurons during development
Gang Chen et al.
Nature Neuroscience 11, 36–44
(January 2008); doi:10.1038/nn2018
| Summary | Full Text (HTML / PDF) |
review
Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
Urs Rutishauser
Nature Reviews Neuroscience 9, 26–35
(January 2008); doi:10.1038/nrn2285
| Summary | Full Text (HTML / PDF) |
review
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
Kishor M. Wasan, Dion R. Brocks, Stephen D. Lee, Kristina Sachs-Barrable & Sheila J. Thornton
Nature Reviews Drug Discovery 7, 84–99
(January 2008); doi:10.1038/nrd2353
| Summary | Full Text (HTML / PDF) |
review
Salmonellae interplay with host cells
Andrea Haraga, Maikke B. Ohlson & Samuel I. Miller
Nature Reviews Microbiology 6, 53–66
(January 2008); doi:10.1038/nrmicro1788
| Summary | Full Text (HTML / PDF) |
article
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B Yu et al.
Nature Chemical Biology 4, 33–41
(January 2008); doi:10.1038/nchembio.2007.54
| Summary | Full Text (HTML / PDF) |
news and views
Small-molecule dissection of BMP signaling
Gregory J Anderson & Deepak Darshan
Nature Chemical Biology 4, 15–16
(January 2008); doi:10.1038/nchembio0108-15
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