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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Scaling of the BMP activation gradient in Xenopus embryos
Danny Ben-Zvi, Ben-Zion Shilo, Abraham Fainsod & Naama Barkai
Nature 453, 1205–1211
(26 June 2008); doi:10.1038/nature07059
| Summary | Full Text (HTML / PDF) |
letter
Analysis of a spatial orientation memory in Drosophila
Kirsa Neuser, Tilman Triphan, Markus Mronz, Burkhard Poeck & Roland Strauss
Nature 453, 1244–1247
(26 June 2008); doi:10.1038/nature07003
| Summary | Full Text (HTML / PDF) |
news and views
Behavioural neuroscience: Out of sight, but not out of mind
Seth M. Tomchik & Ronald L. Davis
Nature 453, 1192–1194
(26 June 2008); doi:10.1038/4531192a
| Full Text (HTML / PDF) |
letter
Structural basis for EGFR ligand sequestration by Argos
Daryl E. Klein, Steven E. Stayrook, Fumin Shi, Kartik Narayan & Mark A. Lemmon
Nature 453, 1271–1275
(26 June 2008); doi:10.1038/nature06978
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article
Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle
Karen Crasta, Hong Hwa Lim, Thomas H. Giddings, Jr, Mark Winey & Uttam Surana
Nature Cell Biology 10, 665–675
doi:10.1038/ncb1729
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article
STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle
Jonathan Stiber et al.
Nature Cell Biology 10, 688–697
doi:10.1038/ncb1731
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news and views
Skeletal muscle dressed in SOCs
Dong Min Shin & Shmuel Muallem
Nature Cell Biology 10, 639–641
(June 2008); doi:10.1038/ncb0608-639
| Full Text (HTML / PDF) |
letter
β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells
Ilaria Taddei et al.
Nature Cell Biology 10, 716–722
doi:10.1038/ncb1734
| Summary | Full Text (HTML / PDF) |
review
The septin family of GTPases: architecture and dynamics
Christine S. Weirich, Jan P. Erzberger & Yves Barral
Nature Reviews Molecular Cell Biology 9, 478–489
(June 2008); doi:10.1038/nrm2407
| Summary | Full Text (HTML / PDF) |
article
A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
Yongzhong Liu et al.
Nature Immunology 9, 632–640
(June 2008); doi:10.1038/ni.1607
| Summary | Full Text (HTML / PDF) |
article
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Nicolas Manel, Derya Unutmaz & Dan R Littman
Nature Immunology 9, 641–649
(June 2008); doi:10.1038/ni.1610
| Summary | Full Text (HTML / PDF) |
article
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
Elisabetta Volpe et al.
Nature Immunology 9, 650–657
(June 2008); doi:10.1038/ni.1613
| Summary | Full Text (HTML / PDF) |
news and views
Differentiation of human TH-17 cells does require TGF-β!
Anne O'Garra, Brigitta Stockinger & Marc Veldhoen
Nature Immunology 9, 588–590
(June 2008); doi:10.1038/ni0608-588
| Full Text (HTML / PDF) |
article
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
Edy Y Kim et al.
Nature Medicine 14, 633–640
(June 2008); doi:10.1038/nm1770
| Summary | Full Text (HTML / PDF) |
news and views
Lung NKT cell commotion takes your breath away
Sebastian Joyce & Luc Van Kaer
Nature Medicine 14, 609–610
(June 2008); doi:10.1038/nm0608-609
| Full Text (HTML / PDF) |
article
Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
Christoph Buettner et al.
Nature Medicine 14, 667–675
(June 2008); doi:10.1038/nm1775
| Summary | Full Text (HTML / PDF) |
news and views
The long reach of leptin
Eleftheria Maratos-Flier
Nature Medicine 14, 604–606
(June 2008); doi:10.1038/nm0608-604
| Full Text (HTML / PDF) |
letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
| Summary | Full Text (HTML / PDF) |
article
Drosophila TRPA channel modulates sugar-stimulated neural excitation, avoidance and social response
Jie Xu, Andrew T Sornborger, Jennifer K Lee & Ping Shen
Nature Neuroscience 11, 676–682
(June 2008); doi:10.1038/nn.2119
| Summary | Full Text (HTML / PDF) |
review
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
Nature Reviews Neuroscience 9, 437–452
(June 2008); doi:10.1038/nrn2392
| Summary | Full Text (HTML / PDF) |
review
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
Masato Furuhashi & Gökhan S. Hotamisligil
Nature Reviews Drug Discovery 7, 489–503
(June 2008); doi:10.1038/nrd2589
| Summary | Full Text (HTML / PDF) |
article
A structural link between inactivation and block of a K+ channel
Christian Ader et al.
Nature Structural & Molecular Biology 15, 605–612
(June 2008); doi:10.1038/nsmb.1430
| Summary | Full Text (HTML / PDF) |
article
Internal dynamics control activation and activity of the autoinhibited Vav DH domain
Pilong Li, Ilídio R S Martins, Gaya K Amarasinghe & Michael K Rosen
Nature Structural & Molecular Biology 15, 613–618
(June 2008); doi:10.1038/nsmb.1428
| Summary | Full Text (HTML / PDF) |
article
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
Alessia Montagnoli et al.
Nature Chemical Biology 4, 357–365
(June 2008); doi:10.1038/nchembio.90
| Summary | Full Text (HTML / PDF) |
news and views
Stopping replication, at the beginning
Peter K Jackson
Nature Chemical Biology 4, 331–332
(June 2008); doi:10.1038/nchembio0608-331
| Full Text (HTML / PDF) |
article
PML targeting eradicates quiescent leukaemia-initiating cells
Keisuke Ito et al.
Nature 453, 1072–1078
(19 June 2008); doi:10.1038/nature07016
| Summary | Full Text (HTML / PDF) |
letter
Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis
Bruno Müller & Jen Sheen
Nature 453, 1094–1097
(19 June 2008); doi:10.1038/nature06943
| Summary | Full Text (HTML / PDF) |
letter
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
Helene R. McMurray et al.
Nature 453, 1112–1116
(19 June 2008); doi:10.1038/nature06973
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Deconstructing oncogenesis
Ji Luo & Stephen J. Elledge
Nature 453, 995–996
(19 June 2008); doi:10.1038/453995a
| Full Text (HTML / PDF) |
letter
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
Keizo Kanasaki et al.
Nature 453, 1117–1121
(19 June 2008); doi:10.1038/nature06951
| Summary | Full Text (HTML / PDF) |
letter
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
Brian G. Fuller et al.
Nature 453, 1132–1136
(19 June 2008); doi:10.1038/nature06923
| Summary | Full Text (HTML / PDF) |
article
The type I TGF-β receptor is covalently modified and regulated by sumoylation
Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst & Rik Derynck
Nature Cell Biology 10, 654–664
(June 2008); doi:10.1038/ncb1728
| Summary | Full Text (HTML / PDF) |
news and views
SUMO amplifies TGF-β signalling
Kohei Miyazono, Yuto Kamiya & Keiji Miyazawa
Nature Cell Biology 10, 635–637
(June 2008); doi:10.1038/ncb0608-635
| Full Text (HTML / PDF) |
letter
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
Xiaoling Tang et al.
Nature Cell Biology 10, 698–706
(June 2008); doi:10.1038/ncb1732
| Summary | Full Text (HTML / PDF) |
letter
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation
Maria Emanuela Cuomo et al.
Nature Cell Biology 10, 723–730
(June 2008); doi:10.1038/ncb1735
| Summary | Full Text (HTML / PDF) |
review
Spatial and temporal coordination of mitosis by Ran GTPase
Paul R. Clarke & Chuanmao Zhang
Nature Reviews Molecular Cell Biology 9, 464–477
(June 2008); doi:10.1038/nrm2410
| Summary | Full Text (HTML / PDF) |
article
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity
Jeff Holst et al.
Nature Immunology 9, 658–666
(June 2008); doi:10.1038/ni.1611
| Summary | Full Text (HTML / PDF) |
news and views
CD3 ITAMs count!
Bernard Malissen
Nature Immunology 9, 583–584
(June 2008); doi:10.1038/ni0608-583
| Full Text (HTML / PDF) |
article
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
Claudia Waskow et al.
Nature Immunology 9, 676–683
(June 2008); doi:10.1038/ni.1615
| Summary | Full Text (HTML / PDF) |
news and views
Homeostasis of dendritic cell pool in lymphoid organs
Cedric Auffray, Yalin Emre & Frederic Geissmann
Nature Immunology 9, 584–586
(June 2008); doi:10.1038/ni0608-584
| Full Text (HTML / PDF) |
letter
Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
Terrence Town et al.
Nature Medicine 14, 681–687
(June 2008); doi:10.1038/nm1781
| Summary | Full Text (HTML / PDF) |
review
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao & Benjamin Moeller
Nature Reviews Cancer 8, 425–437
(June 2008); doi:10.1038/nrc2397
| Summary | Full Text (HTML / PDF) |
perspective
The Mouse Tumor Biology database
Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult & Janan T. Eppig
Nature Reviews Cancer 8, 459–465
(June 2008); doi:10.1038/nrc2390
| Summary | Full Text (HTML / PDF) |
article
Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
Karun K Singh et al.
Nature Neuroscience 11, 649–658
(June 2008); doi:10.1038/nn.2114
| Summary | Full Text (HTML / PDF) |
news and views
Neurotrophins giveth and they taketh away
Alun M Davies
Nature Neuroscience 11, 627–628
(June 2008); doi:10.1038/nn0608-627
| Full Text (HTML / PDF) |
review
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Paolo M. Comoglio, Silvia Giordano & Livio Trusolino
Nature Reviews Drug Discovery 7, 504–516
(June 2008); doi:10.1038/nrd2530
| Summary | Full Text (HTML / PDF) |
article
Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2
Thomas A Bowden et al.
Nature Structural & Molecular Biology 15, 567–572
(June 2008); doi:10.1038/nsmb.1435
| Summary | Full Text (HTML / PDF) |
news and views
Evil versus 'eph-ective' use of ephrin-B2
Benhur Lee, Zeynep Akyol Ataman & Lei Jin
Nature Structural & Molecular Biology 15, 540–542
(June 2008); doi:10.1038/nsmb0608-540
| Full Text (HTML / PDF) |
article
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
Nobutaka Kato et al.
Nature Chemical Biology 4, 347–356
(June 2008); doi:10.1038/nchembio.87
| Summary | Full Text (HTML / PDF) |
news and views
Stopping malaria parasites dead in their tracks
Christian D Doerig
Nature Chemical Biology 4, 334–335
(June 2008); doi:10.1038/nchembio0608-3340
| Full Text (HTML / PDF) |
article
A phosphatase cascade by which rewarding stimuli control nucleosomal response
Alexandre Stipanovich et al.
Nature 453, 879–884
(12 June 2008); doi:10.1038/nature06994
| Summary | Full Text (HTML / PDF) |
letter
Substrate-targeting γ-secretase modulators
Thomas L. Kukar et al.
Nature 453, 925–929
(12 June 2008); doi:10.1038/nature07055
| Summary | Full Text (HTML / PDF) |
news and views
Biochemistry: Molecular cloaking devices
Thomas Kodadek
Nature 453, 861–862
(12 June 2008); doi:10.1038/453861a
| Summary | Full Text (HTML / PDF) |
letter
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
Jennifer S. Ziegenfuss et al.
Nature 453, 935–939
(12 June 2008); doi:10.1038/nature06901
| Summary | Full Text (HTML / PDF) |
letter
Global control of cell-cycle transcription by coupled CDK and network oscillators
David A. Orlando et al.
Nature 453, 944–947
(12 June 2008); doi:10.1038/nature06955
| Summary | Full Text (HTML / PDF) |
article
Regulation of autophagy by cytoplasmic p53
Ezgi Tasdemir et al.
Nature Cell Biology 10, 676–687
(June 2008); doi:10.1038/ncb1730
| Summary | Full Text (HTML / PDF) |
news and views
p53: The Janus of autophagy?
Beth Levine & John Abrams
Nature Cell Biology 10, 637–639
(June 2008); doi:10.1038/ncb0608-637
| Full Text (HTML / PDF) |
letter
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export
Alwin Köhler, Maren Schneider, Ghislain G. Cabal, Ulf Nehrbass & Ed Hurt
Nature Cell Biology 10, 637–639
(June 2008); doi:10.1038/ncb1733
| Summary | Full Text (HTML / PDF) |
letter
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
Scott W. Rowlinson et al.
Nature Cell Biology 10, 740–747
(June 2008); doi:10.1038/ncb1737
| Summary | Full Text (HTML / PDF) |
article
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
Rupesh H Amin & Mark S Schlissel
Nature Immunology 9, 613–622
(June 2008); doi:10.1038/ni.1612
| Summary | Full Text (HTML / PDF) |
article
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K–PKB–Foxo pathway
Sebastian Herzog et al.
Nature Immunology 9, 623–631
(June 2008); doi:10.1038/ni.1616
| Summary | Full Text (HTML / PDF) |
news and views
Foxos around make B cells tolerable
Marta A W Rowh & Craig H Bassing
Nature Immunology 9, 586–588
(June 2008); doi:10.1038/ni0608-586
| Full Text (HTML / PDF) |
article
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
Peter R Wilker et al.
Nature Immunology 9, 603–612
(June 2008); doi:10.1038/ni.1609
| Summary | Full Text (HTML / PDF) |
article
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ
Yumiko Oishi et al.
Nature Medicine 14, 656–666
(June 2008); doi:10.1038/nm1756
| Summary | Full Text (HTML / PDF) |
news and views
Multiple layers of metabolism
Mukesh K Jain
Nature Medicine 14, 603–604
(June 2008); doi:10.1038/nm0608-603
| Summary | Full Text (HTML / PDF) |
article
Activity-dependent site-specific changes of glutamate receptor composition in vivo
Andreas Schmid et al.
Nature Neuroscience 11, 659–666
(June 2008); doi:10.1038/nn.2122
| Summary | Full Text (HTML / PDF) |
article
T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites
Lucius Cueni et al.
Nature Neuroscience 11, 683–692
(June 2008); doi:10.1038/nn.2124
| Summary | Full Text (HTML / PDF) |
review
Presynaptic glutamate receptors: physiological functions and mechanisms of action
Paulo S. Pinheiro & Christophe Mulle
Nature Reviews Neuroscience 11, 423–436
(June 2008); doi:10.1038/nrn2379
| Summary | Full Text (HTML / PDF) |
article
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
Oliver Schilling & Christopher M Overall
Nature Biotechnology 26, 685–694
(June 2008); doi:10.1038/nbt1408
| Summary | Full Text (HTML / PDF) |
news and views
Proteases' prime targets revealed
Scott L Diamond & Doron Greenbaum
Nature Biotechnology 26, 652–653
(June 2008); doi:10.1038/nbt0608-652
| Summary | Full Text (HTML / PDF) |
article
The central unit within the 19S regulatory particle of the proteasome
Rina Rosenzweig et al.
Nature Structural & Molecular Biology 15, 573–580
(June 2008); doi:10.1038/nsmb.14272
| Summary | Full Text (HTML / PDF) |
article
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel et al.
Nature Methods 5, 561–567
(June 2008); doi:10.1038/nmeth.1213
| Summary | Full Text (HTML / PDF) |
article
A two-tiered mechanism for stabilization and immobilization of E-cadherin
Matthieu Cavey, Matteo Rauzi, Pierre-François Lenne & Thomas Lecuit
Nature 453, 751–756
(5 June 2008); doi:10.1038/nature06953
| Summary | Full Text (HTML / PDF) |
letter
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Austin R. Graves, Patricia K. Curran, Carolyn L. Smith & Joseph A. Mindell
Nature 453, 788–792
(5 June 2008); doi:10.1038/nature06907
| Summary | Full Text (HTML / PDF) |
letter
Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells
Yoshinori Kawamura et al.
Nature 453, 793–797
(5 June 2008); doi:10.1038/nature06938
| Summary | Full Text (HTML / PDF) |
letter
An endogenous small interfering RNA pathway in Drosophila
Benjamin Czech et al.
Nature 453, 798–802
(5 June 2008); doi:10.1038/nature07007
| Summary | Full Text (HTML / PDF) |
letter
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs
Katsutomo Okamura et al.
Nature 453, 803–806
(5 June 2008); doi:10.1038/nature07015
| Summary | Full Text (HTML / PDF) |
letter
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Jordi Rius et al.
Nature 453, 807–811
(5 June 2008); doi:10.1038/nature06905
| Summary | Full Text (HTML / PDF) |
letter
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
Robert K. McGinty, Jaehoon Kim, Champak Chatterjee, Robert G. Roeder & Tom W. Muir
Nature 453, 812–816
(5 June 2008); doi:10.1038/nature06906
| Summary | Full Text (HTML / PDF) |
article
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
Xudong Zhao et al.
Nature Cell Biology 10, 643–653
(June 2008); doi:10.1038/ncb1727
| Summary | Full Text (HTML / PDF) |
letter
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
Jiancong Liang et al.
Nature Cell Biology 10, 731–739
(June 2008); doi:10.1038/ncb1736
| Summary | Full Text (HTML / PDF) |
review
Multiple roles for lipids in the Hedgehog signalling pathway
Suzanne Eaton
Nature Reviews Molecular Cell Biology 9, 437–445
(June 2008); doi:10.1038/nrm2414
| Summary | Full Text (HTML / PDF) |
progress
Membrane nanotubes: dynamic long-distance connections between animal cells
Daniel M. Davis & Stefanie Sowinski
Nature Reviews Molecular Cell Biology 9, 431–436
(June 2008); doi:10.1038/nrm2399
| Summary | Full Text (HTML / PDF) |
article
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
Tatsukata Kawagoe et al.
Nature Immunology 9, 684–691
(June 2008); doi:10.1038/ni.1606
| Summary | Full Text (HTML / PDF) |
news and views
IRAK2 takes its place in TLR signaling
Etienne Meylan & Jürg Tschopp
Nature Immunology 9, 581–582
(June 2008); doi:10.1038/ni0608-581
| Full Text (HTML / PDF) |
review
Inhibitory B7-family molecules in the tumour microenvironment
Weiping Zou & Lieping Chen
Nature Reviews Immunology 8, 467–477
(June 2008); doi:10.1038/nri2326
| Summary | Full Text (HTML / PDF) |
review
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
David Frescas & Michele Pagano
Nature Reviews Cancer 8, 438–449
(June 2008); doi:10.1038/nrc2396
| Summary | Full Text (HTML / PDF) |
article
MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary
Christoph Leucht et al.
Nature Neuroscience 11, 641–648
(June 2008); doi:10.1038/nn.2115
| Summary | Full Text (HTML / PDF) |
news and views
microRNA-9 multitasking near organizing centers
Celine Delaloy & Fen-Biao Gao
Nature Neuroscience 11, 625–626
(June 2008); doi:10.1038/nn0608-625
| Full Text (HTML / PDF) |
review
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
Nature Reviews Neuroscience 9, 437–452
(June 2008); doi:10.1038/nrn2392
| Summary | Full Text (HTML / PDF) |
review
The surprisingly diverse ways that prokaryotes move
Ken F. Jarrell & Mark J. McBride
Nature Reviews Microbiology 6, 466–476
(June 2008); doi:10.1038/nrmicro1900
| Summary | Full Text (HTML / PDF) |
article
Real-time imaging of the intracellular glutathione redox potential
Marcus Gutscher et al.
Nature Methods 5, 553–559
(June 2008); doi:10.1038/nmeth.1212
| Summary | Full Text (HTML / PDF) |
article
Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity
Gabriele Meloni et al.
Nature Chemical Biology 4, 366–372
(June 2008); doi:10.1038/nchembio.89
| Summary | Full Text (HTML / PDF) |
article
Activation of the endocannabinoid system by organophosphorus nerve agents
Daniel K Nomura et al.
Nature Chemical Biology 4, 373–378
(June 2008); doi:10.1038/nchembio.86
| Summary | Full Text (HTML / PDF) |
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