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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Structure of a β1-adrenergic G-protein-coupled receptor
Tony Warne et al.
Nature 454, 486–491
(24 July 2008); doi:10.1038/nature07101
| Summary | Full Text (HTML / PDF) |
letter
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
Morgan E. Carlson, Michael Hsu & Irina M. Conboy
Nature 454, 528–532
(24 July 2008); doi:10.1038/nature07034
| Summary | Full Text (HTML / PDF) |
letter
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
Riina M. Luik, Bin Wang, Murali Prakriya, Minnie M. Wu & Richard S. Lewis
Nature 454, 538–542
(24 July 2008); doi:10.1038/nature07065
| Summary | Full Text (HTML / PDF) |
letter
Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations
Kihoon Lee, Yu Zhang & Sang Eun Lee
Nature 454, 543–546
(24 July 2008); doi:10.1038/nature07054
| Summary | Full Text (HTML / PDF) |
review
Origin and physiological roles of inflammation
Ruslan Medzhitov
Nature 454, 428–435
(24 July 2008); doi:10.1038/nature07201
| Summary | Full Text (HTML / PDF) |
review
Cancer-related inflammation
Alberto Mantovani, Paola Allavena, Antonio Sica & Frances Balkwill
Nature 454, 436–444
(24 July 2008); doi:10.1038/nature07205
| Summary | Full Text (HTML / PDF) |
review
The development of allergic inflammation
Stephen J. Galli, Mindy Tsai & Adrian M. Piliponsky
Nature 454, 445–454
(24 July 2008); doi:10.1038/nature07204
| Summary | Full Text (HTML / PDF) |
review
From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang & Randal J. Kaufman
Nature 454, 455–462
(24 July 2008); doi:10.1038/nature07203
| Summary | Full Text (HTML / PDF) |
review
Integration of metabolism and inflammation by lipid-activated nuclear receptors
Steven J. Bensinger & Peter Tontonoz
Nature 454, 470–477
(24 July 2008); doi:10.1038/nature07202
| Summary | Full Text (HTML / PDF) |
article
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
Xaralabos Varelas et al.
Nature Cell Biology 10, 837–848
(July 2008); doi:10.1038/ncb1748
| Summary | Full Text (HTML / PDF) |
article
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Darren J. Baker et al.
Nature Cell Biology 10, 825–836
(July 2008); doi:10.1038/ncb1744
| Summary | Full Text (HTML / PDF) |
letter
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis
Nilkantha Sen et al.
Nature Cell Biology 10, 866–873
(July 2008); doi:10.1038/ncb1747
| Summary | Full Text (HTML / PDF) |
review
Mediators of reprogramming: transcription factors and transitions through mitosis
Dieter Egli, Garrett Birkhoff & Kevin Eggan
Nature Reviews Molecular Cell Biology 9, 505–516
(July 2008); doi:10.1038/nrm2439
| Summary | Full Text (HTML / PDF) |
review
Mechanisms of membrane fusion: disparate players and common principles
Sascha Martens & Harvey T. McMahon
Nature Reviews Molecular Cell Biology 9, 543–556
(July 2008); doi:10.1038/nrm2417
| Summary | Full Text (HTML / PDF) |
article
Structure of and influence of a tick complement inhibitor on human complement component 5
Folmer Fredslund et al.
Nature Immunology 9, 753–760
(July 2008); doi:10.1038/ni.1625
| Summary | Full Text (HTML / PDF) |
article
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
Satoshi Uematsu et al.
Nature Immunology 9, 769–776
(July 2008); doi:10.1038/ni.1622
| Summary | Full Text (HTML / PDF) |
article
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
Shinichiro Yamamoto et al.
Nature Medicine 14, 738–747
(July 2008); doi:10.1038/nm1758
| Summary | Full Text (HTML / PDF) |
letter
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
Ignacio Varela et al.
Nature Medicine 14, 767–772
(July 2008); doi:10.1038/nm1786
| Summary | Full Text (HTML / PDF) |
news and views
Rejuvenating premature aging
Eran Meshorer & Yosef Gruenbaum
Nature Medicine 14, 713–715
(July 2008); doi:10.1038/nm0708-713
| Full Text (HTML / PDF) |
perspective
Exploring the role of cancer stem cells in radioresistance
Michael Baumann, Mechthild Krause & Richard Hill
Nature Reviews Cancer 8, 545–554
(July 2008); doi:10.1038/nrc2419
| Summary | Full Text (HTML / PDF) |
article
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Rainer Fagerholm et al.
Nature Genetics 40, 844–853
doi:10.1038/ng.155
| Summary | Full Text (HTML / PDF) |
review
The art and design of genetic screens: RNA interference
Michael Boutros & Julie Ahringer
Nature Reviews Genetics 9, 554–566
(July 2008); doi:10.1038/nrg2364
| Summary | Full Text (HTML / PDF) |
article
Evolutionary expansion and anatomical specialization of synapse proteome complexity
Richard D Emes et al.
Nature Neuroscience 11, 799–806
doi:10.1038/nn.2135
| Summary | Full Text (HTML / PDF) |
article
Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo
Corey M McCann, Juan Carlos Tapia, Han Kim, Jay S Coggan & Jeff W Lichtman
Nature Neuroscience 11, 807–815
doi:10.1038/nn.2145
| Summary | Full Text (HTML / PDF) |
article
An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Ofra Benny et al.
Nature Biotechnology 26, 799–807
(July 2008); doi:10.1038/nbt1415
| Summary | Full Text (HTML / PDF) |
news and views
Hitting the mother lode of tumor angiogenesis
Daylon James, Sina Rabbany & Shahin Rafii
Nature Biotechnology 26, 769–770
(July 2008); doi:10.1038/nbt0708-769
| Full Text (HTML / PDF) |
review
Molecular imaging in drug development
Jürgen K. Willmann, Nicholas van Bruggen, Ludger M. Dinkelborg & Sanjiv S. Gambhir
Nature Reviews Drug Discovery 7, 591–607
(July 2008); doi:10.1038/nrd2290
| Summary | Full Text (HTML / PDF) |
brief communication
A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
Nina Pirher, Karolina Ivičak, Jelka Pohar, Mojca Benčina & Roman Jerala
Nature Structural & Molecular Biology 15, 761–763
(July 2008); doi:10.1038/nsmb.1453
| Summary | Full Text (HTML / PDF) |
article
Stem cell transcriptome profiling via massive-scale mRNA sequencing
Nicole Cloonan et al.
Nature Methods 5, 613–619
(July 2008); doi:10.1038/nmeth.1223
| Summary | Full Text (HTML / PDF) |
article
Positive feedback of G1 cyclins ensures coherent cell cycle entry
Jan M. Skotheim, Stefano Di Talia, Eric D. Siggia & Frederick R. Cross
Nature 454, 291–296
(17 July 2008); doi:10.1038/nature07118
| Summary | Full Text (HTML / PDF) |
letter
Positive feedback sharpens the anaphase switch
Liam J. Holt, Andrew N. Krutchinsky & David O. Morgan
Nature 454, 353–357
(17 July 2008); doi:10.1038/nature07050
| Summary | Full Text (HTML / PDF) |
news and views
Systems biology: On the cell cycle and its switches
Silvia D. M. Santos & James E. Ferrell
Nature 454, 288–289
(17 July 2008); doi:10.1038/454288a
| Full Text (HTML / PDF) |
letter
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
Weidong Zhu et al.
Nature 454, 345–349
(17 July 2008); doi:10.1038/nature07027
| Summary | Full Text (HTML / PDF) |
letter
IL-21 and TGF-β are required for differentiation of human TH17 cells
Li Yang et al.
Nature 454, 350–352
(17 July 2008); doi:10.1038/nature07021
| Summary | Full Text (HTML / PDF) |
article
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
Irene García-Higuera et al.
Nature Cell Biology 10, 802–811
(July 2008); doi:10.1038/ncb1742
| Summary | Full Text (HTML / PDF) |
news and views
Cdh1: a master G0/G1 regulator
Jeffrey R. Skaar & Michele Pagano
Nature Cell Biology 10, 755–757
(July 2008); doi:10.1038/ncb0708-755
| Full Text (HTML / PDF) |
review
Cytochrome c: functions beyond respiration
Yong-Ling P. Ow, Douglas R. Green, Zhenyue Hao & Tak W. Mak
Nature Reviews Molecular Cell Biology 9, 532–542
(July 2008); doi:10.1038/nrm2434
| Summary | Full Text (HTML / PDF) |
article
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils
Bryan Heit et al.
Nature Immunology 9, 743–752
(July 2008); doi:10.1038/ni.1623
| Summary | Full Text (HTML / PDF) |
news and views
PTEN gives neutrophils direction
Daniel D Billadeau
Nature Immunology 9, 716–718
(July 2008); doi:10.1038/ni0708-716
| Full Text (HTML / PDF) |
review
How regulatory T cells work
Dario A. A. Vignali, Lauren W. Collison & Creg J. Workman
Nature Reviews Immunology 8, 523–532
(July 2008); doi:10.1038/nri2343
| Summary | Full Text (HTML / PDF) |
article
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
Enming J Su et al.
Nature Medicine 14, 731–737
(July 2008); doi:10.1038/nm1787
| Summary | Full Text (HTML / PDF) |
news and views
Imatinib buys time for brain after stroke
Peter Rieckmann
Nature Medicine 14, 712–713
(July 2008); doi:10.1038/nm0708-712
| Full Text (HTML / PDF) |
perspective
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
David R. Croucher, Darren N. Saunders, Sergei Lobov & Marie Ranson
Nature Reviews Cancer 8, 535–545
(July 2008); doi:10.1038/nrc2400
| Summary | Full Text (HTML / PDF) |
article
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells
Tae Joo Park, Brian J Mitchell, Philip B Abitua, Chris Kintner & John B Wallingford
Nature Genetics 40, 871–879
doi:10.1038/ng.104
| Summary | Full Text (HTML / PDF) |
article
The binding sites for cocaine and dopamine in the dopamine transporter overlap
Thijs Beuming et al.
Nature Neuroscience 11, 780–789
doi:10.1038/nn.2146
| Summary | Full Text (HTML / PDF) |
review
Mitochondrial fragmentation in neurodegeneration
Andrew B. Knott, Guy Perkins, Robert Schwarzenbacher & Ella Bossy-Wetzel
Nature Reviews Neuroscience 9, 505–518
(July 2008); doi:10.1038/nrn2417
| Summary | Full Text (HTML / PDF) |
research
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1
Yukihiko Aikawa et al.
Nature Biotechnology 26, 817–823
(July 2008); doi:10.1038/nbt1412
| Summary | Full Text (HTML / PDF) |
review
Membrane fusion
William Wickner & Randy Schekman
Nature Structural & Molecular Biology 15, 658–664
(July 2008); doi:10.1038/nsmb.1451
| Summary | Full Text (HTML / PDF) |
review
Advances in bacterial promoter recognition and its control by factors that do not bind DNA
Shanil P. Haugen, Wilma Ross & Richard L. Gourse
Nature Reviews Microbiology 6, 507–519
(July 2008); doi:10.1038/nrmicro1912
| Summary | Full Text (HTML / PDF) |
article
Functional immobilization of signaling proteins enables control of stem cell fate
Kristin Alberti et al.
Nature Methods 5, 645–650
(July 2008); doi:10.1038/nmeth.1222
| Summary | Full Text (HTML / PDF) |
brief communication
In vitro whole-organ imaging: 4D quantification of growing mouse limb buds
Marit J Boot et al.
Nature Methods 5, 609–612
(July 2008); doi:10.1038/nmeth.1219
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of the ligand-free G-protein-coupled receptor opsin
Jung Hee Park, Patrick Scheerer, Klaus Peter Hofmann, Hui-Woog Choe & Oliver Peter Ernst
Nature 454, 183–187
(10 July 2008); doi:10.1038/nature07063
| Summary | Full Text (HTML / PDF) |
letter
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia
Aline Bozec et al.
Nature 454, 221–225
(10 July 2008); doi:10.1038/nature07019
| Summary | Full Text (HTML / PDF) |
letter
IRF4 addiction in multiple myeloma
Arthur L. Shaffer et al.
Nature 454, 226–231
(10 July 2008); doi:10.1038/nature07064
| Summary | Full Text (HTML / PDF) |
letter
Essential role for Nix in autophagic maturation of erythroid cells
Hector Sandoval et al.
Nature 454, 232–235
(10 July 2008); doi:10.1038/nature07006
| Summary | Full Text (HTML / PDF) |
letter
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage
Ralph A. Neumüller et al.
Nature 454, 241–245
(10 July 2008); doi:10.1038/nature07014
| Summary | Full Text (HTML / PDF) |
article
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Chengyu Liang et al.
Nature Cell Biology 10, 776–787
(July 2008); doi:10.1038/ncb1740
| Summary | Full Text (HTML / PDF) |
news and views
UVRAG reveals its second nature
Karolina Peplowska, Margarita Cabrera & Christian Ungermann
Nature Cell Biology 10, 759–761
(July 2008); doi:10.1038/ncb0708-759
| Full Text (HTML / PDF) |
letter
WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2
Petra Beli, Debora Mascheroni, Dalu Xu & Metello Innocenti
Nature Cell Biology 10, 849–857
(July 2008); doi:10.1038/ncb1745
| Summary | Full Text (HTML / PDF) |
review
Ras oncogenes: split personalities
Antoine E. Karnoub & Robert A. Weinberg
Nature Reviews Molecular Cell Biology 9, 517–531
(July 2008); doi:10.1038/nrm2438
| Summary | Full Text (HTML / PDF) |
article
An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells
Erin J Adams, Pavel Strop, Sunny Shin, Yueh-Hsiu Chien & K Christopher Garcia
Nature Immunology 9, 777–784
(July 2008); doi:10.1038/ni.1620
| Summary | Full Text (HTML / PDF) |
review
Deubiquitylation and regulation of the immune response
Shao-Cong Sun
Nature Reviews Immunology 8, 501–511
(July 2008); doi:10.1038/nri2337
| Summary | Full Text (HTML / PDF) |
review
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
Nature Reviews Cancer 8, 512–522
(July 2008); doi:10.1038/nrc2440
| Summary | Full Text (HTML / PDF) |
article
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
Jun Zhu et al.
Nature Genetics 40, 854–861
doi:10.1038/ng.167
| Summary | Full Text (HTML / PDF) |
letter
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos
Chi-Wei Lu, Akiko Yabuuchi, Lingyi Chen, Srinivas Viswanathan, Kitai Kim & George Q Daley
Nature Genetics 40, 921–926
doi:10.1038/ng.173
| Summary | Full Text (HTML / PDF) |
review
Retinoic acid in development: towards an integrated view
Karen Niederreither & Pascal Dollé
Nature Reviews Genetics 9, 541–553
doi:10.1038/nrg2340
| Summary | Full Text (HTML / PDF) |
article
Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning
Makoto Nishiyama, Melanie J von Schimmelmann, Kazunobu Togashi, William M Findley & Kyonsoo Hong
Nature Neuroscience 11, 762–771
doi:10.1038/nn.2130
| Summary | Full Text (HTML / PDF) |
review
Purinergic signalling and disorders of the central nervous system
Geoffrey Burnstock
Nature Reviews Drug Discovery 7, 575–590
(July 2008); doi:10.1038/nrd2605
| Summary | Full Text (HTML / PDF) |
review
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Roberto Cattaneo, Tanner Miest, Elena V. Shashkova & Michael A. Barry
Nature Reviews Microbiology 6, 529–540
(July 2008); doi:10.1038/nrmicro1927
| Summary | Full Text (HTML / PDF) |
article
Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans
Kwanghun Chung, Matthew M Crane & Hang Lu
Nature Methods 5, 637–643
(July 2008); doi:10.1038/nmeth.1227
| Summary | Full Text (HTML / PDF) |
news and views
Microfluidics: streamlining discovery in worm biology
S Elizabeth Hulme, Sergey S Shevkoplyas & Aravinthan Samuel
Nature Methods 5, 589–590
(July 2008); doi:10.1038/nmeth0708-589
| Full Text (HTML / PDF) |
perspective
Insights into signaling from the β2-adrenergic receptor structure
Martin Audet & Michel Bouvier
Nature Chemical Biology 4, 397–403
(July 2008); doi:10.1038/nchembio.97
| Summary | Full Text (HTML / PDF) |
article
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
Melanie Winter et al.
Nature Cell Biology 10, 812–824
(July 2008); doi:10.1038/ncb1743
| Summary | Full Text (HTML / PDF) |
article
RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation
Yukiko Nakaya, Erike W. Sukowati, Yuping Wu & Guojun Sheng
Nature Cell Biology 10, 765–775
(July 2008); doi:10.1038/ncb1739
| Summary | Full Text (HTML / PDF) |
news and views
Breaking down EMT
Romain Levayer & Thomas Lecuit
Nature Cell Biology 10, 757–759
(July 2008); doi:10.1038/ncb0708-757
| Full Text (HTML / PDF) |
review
A gene regulatory network orchestrates neural crest formation
Tatjana Sauka-Spengler & Marianne Bronner-Fraser
Nature Reviews Molecular Cell Biology 9, 557–568
(July 2008); doi:10.1038/nrm2428
| Summary | Full Text (HTML / PDF) |
perspective
Endosomal sorting and signalling: an emerging role for sorting nexins
Peter J. Cullen
Nature Reviews Molecular Cell Biology 9, 574–582
(July 2008); doi:10.1038/nrm2427
| Summary | Full Text (HTML / PDF) |
article
A Toll-like receptor 2–integrin β3 complex senses bacterial lipopeptides via vitronectin
Gisa Gerold et al.
Nature Immunology 9, 761–768
(July 2008); doi:10.1038/ni.1618
| Summary | Full Text (HTML / PDF) |
article
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
Stephen J Loughran et al.
Nature Immunology 9, 810–819
(July 2008); doi:10.1038/ni.1617
| Summary | Full Text (HTML / PDF) |
news and views
Erg in stem cells: a function emerges
Ellen V Rothenberg
Nature Immunology 9, 714–716
(July 2008); doi:10.1038/ni0708-714
| Full Text (HTML / PDF) |
review
Colony-stimulating factors in inflammation and autoimmunity
John A. Hamilton
Nature Reviews Immunology 8, 533–544
(July 2008); doi:10.1038/nri2356
| Summary | Full Text (HTML / PDF) |
review
MYB function in normal and cancer cells
Robert G. Ramsay & Thomas J. Gonda
Nature Reviews Cancer 8, 523–534
(July 2008); doi:10.1038/nrc2439
| Summary | Full Text (HTML / PDF) |
article
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
Yuzhen Zhang et al.
Nature Genetics 40, 862–870
doi:10.1038/ng.157
| Summary | Full Text (HTML / PDF) |
news and views
Lung stem cells in the balance
Saverio Bellusci
Nature Genetics 40, 822–823
(July 2008); doi:10.1038/ng0708-822
| Full Text (HTML / PDF) |
brief communication
Critical role of TRPC6 channels in the formation of excitatory synapses
Jian Zhou et al.
Nature Neuroscience 11, 741–743
doi:10.1038/nn.2127
| Summary | Full Text (HTML / PDF) |
review
Animal models of Alzheimer's disease and frontotemporal dementia
Jürgen Götz & Lars M. Ittner
Nature Reviews Neuroscience 9, 532–544
(July 2008); doi:10.1038/nrn2420
| Summary | Full Text (HTML / PDF) |
article
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion
Tae-Young Yoon et al.
Nature Structural & Molecular Biology 15, 707–713
(July 2008); doi:10.1038/nsmb.1446
| Summary | Full Text (HTML / PDF) |
article
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer & Barbara Wold
Nature Methods 5, 621–628
(July 2008); doi:10.1038/nmeth.1226
| Summary | Full Text (HTML / PDF) |
news and views
The beginning of the end for microarrays?
Jay Shendure
Nature Methods 5, 585–587
(July 2008); doi:10.1038/nmeth0708-585
| Full Text (HTML / PDF) |
brief communication
Lifeact: a versatile marker to visualize F-actin
Julia Riedl et al.
Nature Methods 5, 605–607
(July 2008); doi:10.1038/nmeth.1220
| Summary | Full Text (HTML / PDF) |
article
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Emmelie Å Jansson et al.
Nature Chemical Biology 4, 411–417
(July 2008); doi:10.1038/nchembio.92
| Summary | Full Text (HTML / PDF) |
scientific report
Crucial structural role for the PH and C1 domains of the Vav1 exchange factor
Jonathan Rapley, Victor L J Tybulewicz & Katrin Rittinger
EMBO reports 9, 655–661
doi:10.1038/embor.2008.80
| Summary | Full Text (HTML / PDF) |
scientific report
Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles
Christian Ghiglione, Olivier Devergne, Delphine Cerezo & Stéphane Noselli
EMBO reports 9, 676–682
doi:10.1038/embor.2008.79
| Summary | Full Text (HTML / PDF) |
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