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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Crystal structure of opsin in its G-protein-interacting conformation
Patrick Scheerer et al.
Nature 455, 497–502
(25 September 2008); doi:10.1038/nature07330
| Summary | Full Text (HTML / PDF) |
news and views
Structural Biology: A moving story of receptors
Thue W. Schwartz & Wayne L. Hubbell
Nature 455, 473–474
(September 2008); doi:10.1038/455473a;
| Full Text (HTML / PDF) |
letter
FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
Wanzhong He et al.
Nature 455, 542–546
(25 September 2008); doi:10.1038/nature07255
| Summary | Full Text (HTML / PDF) |
letter
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein et al.
Nature 455, 547–551
(25 September 2008); doi:10.1038/nature07179
| Summary | Full Text (HTML / PDF) |
letter
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
Erick J. Morris et al.
Nature 455, 552–556
(25 September 2008); doi:10.1038/nature07310
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Entangled pathways
René Bernards
Nature 455, 479–480
(September 2008); doi:10.1038/455479a;
| Full Text (HTML / PDF) |
article
A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth
Michael Wanzel et al.
Nature Cell Biology 10, 1051–1061
(25 September 2008); doi:10.1038/ncb1764
| Summary | Full Text (HTML / PDF) |
letter
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
Zheng Fu et al.
Nature Cell Biology 10, 1076–1082
(25 September 2008); doi:10.1038/ncb1767
| Summary | Full Text (HTML / PDF) |
review
A complex barcode underlies the heterogeneous response of p53 to stress
Fiona Murray-Zmijewski, Elizabeth A. Slee & Xin Lu
Nature Reviews Molecular Cell Biology 9, 702–712
(September 2008); doi:10.1038/nrm2451
| Summary | Full Text (HTML / PDF) |
perspective
Blebs lead the way: how to migrate without lamellipodia
Guillaume Charras & Ewa Paluch
Nature Reviews Molecular Cell Biology 9, 730–736
(September 2008); doi:10.1038/nrm2453
| Summary | Full Text (HTML / PDF) |
article
The kinase p38α serves cell type—specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
Chun Kim et al.
Nature Immunology 9, 1019–1027
(September 2008); doi:10.1038/ni.1640
| Summary | Full Text (HTML / PDF) |
review
Orchestrating the orchestrators: chemokines in control of T cell traffic
Shannon K Bromley, Thorsten R Mempel & Andrew D Luster
Nature Immunology 9, 970–980
(September 2008); doi:10.1038/ni.f.213
| Summary | Full Text (HTML / PDF) |
review
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
Oreste Acuto, Vincenzo Di Bartolo & Frédérique Michel
Nature Reviews Immunology 8, 699–712
(September 2008); doi:10.1038/nri2397
| Summary | Full Text (HTML / PDF) |
letter
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption
Eun-Ju Chang et al.
Nature Medicine 14, 966–972
(September 2008); doi:10.1038/nm.1860
| Summary | Full Text (HTML / PDF) |
review
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Deborah L. Burkhart & Julien Sage
Nature Reviews Cancer 8, 671–682
(September 2008); doi:10.1038/nrc2399
| Summary | Full Text (HTML / PDF) |
review
Towards a cyberinfrastructure for the biological sciences: progress, visions and challenges
Lincoln D. Stein
Nature Reviews Genetics 9, 678–688
(September 2008); doi:10.1038/nrg2414
| Summary | Full Text (HTML / PDF) |
article
Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking
Michel C Van den Oever et al.
Nature Neuroscience 11, 1053–1058
(September 2008); doi:10.1038/nn.2165
| Summary | Full Text (HTML / PDF) |
review
Molecular mechanisms of L-DOPA-induced dyskinesia
Peter Jenner
Nature Reviews Neuroscience 9, 665–677
(September 2008); doi:10.1038/nrn2471
| Summary | Full Text (HTML / PDF) |
research
Predicting PDZ domain–peptide interactions from primary sequences
Jiunn R Chen, Bryan H Chang, John E Allen, Michael A Stiffler & Gavin MacBeath
Nature Biotechnology 26, 1041–1045
(September 2008); doi:10.1038/nbt.1489
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review
Targeting of tetraspanin proteins — potential benefits and strategies
Martin E. Hemler
Nature Reviews Drug Discovery 7, 747–758
(September 2008); doi:10.1038/nrd2659
| Summary | Full Text (HTML / PDF) |
article
The HP1–p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells
Jean-Pierre Quivy, Annabelle Gérard, Adam J L Cook, Danièle Roche & Geneviève Almouzni
Nature Structural & Molecular Biology 15, 972–979
(September 2008) doi:10.1038/nsmb.1470
| Summary | Full Text (HTML / PDF) |
review
Molecular mechanisms of mechanosensing and their roles in fungal contact sensing
Carol A. Kumamoto
Nature Reviews Microbiology 6, 667–673
(September 2008); doi:10.1038/nrmicro1960
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article
Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor
Damian J Wallace et al.
Nature Methods 5, 797–804
(September 2008); doi:10.1038/nmeth.1242
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article
A genetically encoded calcium indicator for chronic in vivo two-photon imaging
Marco Mank et al.
Nature Methods 5, 805–811
(September 2008); doi:10.1038/nmeth.1243
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news and views
Genetically encoded Ca2+ sensors come of age
Nathalie L Rochefort & Arthur Konnerth
Nature Methods 5, 761–762
(September 2008); doi:10.1038/nmeth0908-761
| Full Text (HTML / PDF) |
article
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Rémi Lasserre et al.
Nature Chemical Biology 4, 538–547
(September 2008); doi:10.1038/nchembio.103
| Summary | Full Text (HTML / PDF) |
article
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
Yusuke Sato et al.
Nature 455, 358–362
(18 September 2008); doi:10.1038/nature07254
| Summary | Full Text (HTML / PDF) |
letter
Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection
Liliana Soroceanu, Armin Akhavan & Charles S. Cobbs
Nature 455, 391–395
(18 September 2008); doi:10.1038/nature07209
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letter
Regulatory networks define phenotypic classes of human stem cell lines
Franz-Josef Müller et al.
Nature 455, 401–405
(18 September 2008); doi:10.1038/nature07213
| Summary | Full Text (HTML / PDF) |
letter
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
Nature 455, 406–410
(18 September 2008); doi:10.1038/nature07275
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Hedgehog's other great trick
Tom Curran & Jessica M. Y. Ng
Nature 455, 293–294
(18 September 2008); doi:10.1038/455293a
| Full Text (HTML / PDF) |
letter
S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
Alexi Nott, P. Marc Watson, James D. Robinson, Luca Crepaldi & Antonella Riccio
Nature 455, 411–415
(18 September 2008); doi:10.1038/nature07238
| Summary | Full Text (HTML / PDF) |
letter
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
Xian Zhang et al.
Nature Cell Biology 10, 1062–1068
(September 2008); doi:10.1038/ncb1765
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news and views
A tal(in) of cell spreading
Margaret Frame & Jim Norman
Nature Cell Biology 10, 1017–1019
(September 2008); doi:10.1038/ncb0908-1017
| Full Text (HTML / PDF) |
letter
Ripples from neighbouring transcription
Miki Ebisuya, Takuya Yamamoto, May Nakajima & Eisuke Nishida
Nature Cell Biology 10, 1106–1113
(September 2008); doi:10.1038/ncb1771
| Summary | Full Text (HTML / PDF) |
news and views
Non-coding RNA transcription: turning on neighbours
Piero Carninci
Nature Cell Biology 10, 1023–1024
(September 2008); doi:10.1038/ncb0908-1023
| Full Text (HTML / PDF) |
review
Conserved functions of the pRB and E2F families
Sander van den Heuvel & Nicholas J. Dyson
Nature Reviews Molecular Cell Biology 9, 713–724
(September 2008); doi:10.1038/nrm2469
| Summary | Full Text (HTML / PDF) |
article
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D
Noam Stern-Ginossar et al.
Nature Immunology 9, 1065–1073
(September 2008); doi:10.1038/ni.1642
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news and views
Regulation of NKG2D ligands: a purposeful but delicate affair
Thomas Spies
Nature Immunology 9, 1013–1015
(September 2008); doi:10.1038/ni0908-1013
| Full Text (HTML / PDF) |
perspective
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
Nature Reviews Cancer 8, 705–713
(September 2008); doi:10.1038/nrc2468
| Summary | Full Text (HTML / PDF) |
letter
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation
Carine Le Goff et al.
Nature Genetics 40, 1119–1123
(September 2008); doi:10.1038/ng.199
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review
The multiple lives of NMD factors: balancing roles in gene and genome regulation
Olaf Isken & Lynne E. Maquat
Nature Reviews Genetics 9, 699–712
(September 2008); doi:10.1038/nrg2402
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article
A subset of octopaminergic neurons are important for Drosophila aggression
Chuan Zhou, Yong Rao & Yi Rao
Nature Neuroscience 11, 1059–1067
(September 2008); doi:10.1038/nn.2164
| Summary | Full Text (HTML / PDF) |
news and views
Octopamine fuels fighting flies
Christopher J Potter & Liqun Luo
Nature Neuroscience 11, 989–990
(September 2008); doi:10.1038/nn0908-989
| Full Text (HTML / PDF) |
review
The genetics of early telencephalon patterning: some assembly required
Jean M. Hébert & Gord Fishell
Nature Reviews Neuroscience 9, 678–685
(September 2008); doi:10.1038/nrn2463
| Summary | Full Text (HTML / PDF) |
review
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
György Haskó, Joel Linden, Bruce Cronstein & Pál Pacher
Nature Reviews Drug Discovery 7, 759–770
(September 2008); doi:10.1038/nrd2638
| Summary | Full Text (HTML / PDF) |
article
SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction
Saskia B Neher, Niels Bradshaw, Stephen N Floor, John D Gross & Peter Walter
Nature Structural & Molecular Biology 15, 916–923
(September 2008); doi:10.1038/nsmb.1467
| Summary | Full Text (HTML / PDF) |
perspective
Molecular eco-systems biology: towards an understanding of community function
Jeroen Raes & Peer Bork
Nature Reviews Microbiology 6, 693–699
(September 2008); doi:10.1038/nrmicro1935
| Summary | Full Text (HTML / PDF) |
article
Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP
Yan-Ming Guo et al.
Nature Methods 5, 835–841
(September 2008); doi:10.1038/nmeth.1238
| Summary | Full Text (HTML / PDF) |
article
Cytosporone B is an agonist for nuclear orphan receptor Nur77
Yanyan Zhan et al.
Nature Chemical Biology 4, 548–556
(September 2008); doi:10.1038/nchembio.106
| Summary | Full Text (HTML / PDF) |
article
Strigolactone inhibition of shoot branching
Victoria Gomez-Roldan et al.
Nature 455, 189–194
(11 September 2008); doi:10.1038/nature07271
| Summary | Full Text (HTML / PDF) |
article
Inhibition of shoot branching by new terpenoid plant hormones
Mikihisa Umehara et al.
Nature 455, 195–200
(11 September 2008); doi:10.1038/nature07272
| Summary | Full Text (HTML / PDF) |
news and views
Plant biology: Hormones branch out
Harry Klee
Nature 455, 176–177
(11 September 2008); doi:10.1038/455176a
| Full Text (HTML / PDF) |
letter
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
Marko Pesu et al.
Nature 455, 246–250
(11 September 2008); doi:10.1038/nature07210
| Summary | Full Text (HTML / PDF) |
letter
Heterochromatin links to centromeric protection by recruiting shugoshin
Yuya Yamagishi, Takeshi Sakuno, Mari Shimura & Yoshinori Watanabe
Nature 455, 251–255
(11 September 2008); doi:10.1038/nature07217
| Summary | Full Text (HTML / PDF) |
article
Identification of genes that regulate epithelial cell migration using an siRNA screening approach
Kaylene J. Simpson et al.
Nature Cell Biology 10, 1027–1038
(September 2008); doi:10.1038/ncb1762
| Summary | Full Text (HTML / PDF) |
letter
p53 mRNA controls p53 activity by managing Mdm2 functions
Marco M. Candeias et al.
Nature Cell Biology 10, 1098–1105
(September 2008); doi:10.1038/ncb1770
| Summary | Full Text (HTML / PDF) |
review
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Sarah J. Heasman & Anne J. Ridley
Nature Reviews Molecular Cell Biology 9, 690–701
(September 2008); doi:10.1038/nrm2476
| Summary | Full Text (HTML / PDF) |
article
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
Maria A Ermolaeva et al.
Nature Immunology 9, 1037–1046
(September 2008); doi:10.1038/ni.1638
| Summary | Full Text (HTML / PDF) |
article
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors
Yelena L Pobezinskaya et al.
Nature Immunology 9, 1047–1054
(September 2008); doi:10.1038/ni.1639
| Summary | Full Text (HTML / PDF) |
news and views
A birthday gift for TRADD
Gioacchino Natoli & Liv M I Austenaa
Nature Immunology 9, 1015–1016
(September 2008); doi:10.1038/ni0908-1015
| Full Text (HTML / PDF) |
review
The endoplasmic reticulum stress response in immunity and autoimmunity
Derrick J. Todd, Ann-Hwee Lee & Laurie H. Glimcher
Nature Reviews Immunology 8, 663–674
(September 2008); doi:10.1038/nri2359
| Summary | Full Text (HTML / PDF) |
article
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
Christian Faul et al.
Nature Medicine 14, 931–938
(September 2008); doi:10.1038/nm.1857
| Summary | Full Text (HTML / PDF) |
review
A new MAFia in cancer
Alain Eychène, Nathalie Rocques & Celio Pouponnot
Nature Reviews Cancer 8, 683–693
(September 2008); doi:10.1038/nrc2460
| Summary | Full Text (HTML / PDF) |
perspective
Tailoring to RB: tumour suppressor status and therapeutic response
Erik S. Knudsen & Karen E. Knudsen
Nature Reviews Cancer 8, 714–724
(September 2008); doi:10.1038/nrc2401
| Summary | Full Text (HTML / PDF) |
letter
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling
Steven Hoseong Yang et al.
Nature Genetics 40, 1130–1135
(September 2008); doi:10.1038/ng.192
| Summary | Full Text (HTML / PDF) |
news and views
Hedgehog in Wnterland
Dennis Roop & Rune Toftgård
Nature Genetics 40, 1040–1041
(September 2008); doi:10.1038/ng0908-1040
| Full Text (HTML / PDF) |
review
EvoD/Vo: the origins of BMP signalling in the neuroectoderm
Claudia Mieko Mizutani & Ethan Bier
Nature Reviews Genetics 9, 663–677
(September 2008); doi:10.1038/nrg2417
| Summary | Full Text (HTML / PDF) |
article
Pore region of TRPV3 ion channel is specifically required for heat activation
Jörg Grandl et al.
Nature Neuroscience 11, 1007–1013
(September 2008); doi:10.1038/nn.2169
| Summary | Full Text (HTML / PDF) |
letter
Photoswitchable fluorescent proteins enable monochromatic multilabel imaging and dual color fluorescence nanoscopy
Martin Andresen et al.
Nature Biotechnology 26, 1035–1040
(September 2008); doi:10.1038/nbt.1493
| Summary | Full Text (HTML / PDF) |
article
Structural basis for the activation of PPARγ by oxidized fatty acids
Toshimasa Itoh et al.
Nature Structural & Molecular Biology 15, 924–931
(September 2008); doi:10.1038/nsmb.1474
| Summary | Full Text (HTML / PDF) |
news and views
Insights into PPARγ from structures with endogenous and covalently bound ligands
Kendall W Nettles
Nature Structural & Molecular Biology 15, 893–895
(September 2008); doi:10.1038/nsmb0908-893
| Full Text (HTML / PDF) |
article
Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data
Anton Valouev et al.
Nature Methods 5, 829–834
(September 2008); doi:10.1038/nmeth.1246
| Summary | Full Text (HTML / PDF) |
article
β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana
Zheming Wang et al.
Nature Chemical Biology 4, 557–563
(September 2008); doi:10.1038/nchembio.104
| Summary | Full Text (HTML / PDF) |
news and views
Unexpected N-terminal editing: a cysteine protease that cuts and pastes
Isaac Carrico
Nature Chemical Biology 4, 525–526
(September 2008); doi:10.1038/nchembio0908-525
| Full Text (HTML / PDF) |
article
Widespread changes in protein synthesis induced by microRNAs
Matthias Selbach et al.
Nature 455, 58–63
(04 September 2008); doi:10.1038/nature07228
| Summary | Full Text (HTML / PDF) |
article
The impact of microRNAs on protein output
Daehyun Baek et al.
Nature 455, 64–71
(04 September 2008); doi:10.1038/nature07242
| Summary | Full Text (HTML / PDF) |
news and views
Small RNAs: The seeds of silence
Zissimos Mourelatos
Nature 455, 44–45
(04 September 2008); doi:10.1038/455044a
| Full Text (HTML / PDF) |
article
Type IV collagens regulate BMP signalling in Drosophila
Xiaomeng Wang, Robin E. Harris, Laura J. Bayston & Hilary L. Ashe
Nature 455, 72–77
(04 September 2008); doi:10.1038/nature07214
| Summary | Full Text (HTML / PDF) |
letter
Molecular architecture of native HIV-1 gp120 trimers
Jun Liu, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro & Sriram Subramaniam
Nature 455, 109–113
(04 September 2008); doi:10.1038/nature07159
| Summary | Full Text (HTML / PDF) |
letter
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2
Julian Ik-Tsen Heng et al.
Nature 455, 114–118
(04 September 2008); doi:10.1038/nature07198
| Summary | Full Text (HTML / PDF) |
letter
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
Libor Macůrek et al.
Nature 455, 119–123
(04 September 2008); doi:10.1038/nature07185
| Summary | Full Text (HTML / PDF) |
letter
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Holger Rehmann et al.
Nature 455, 124–127
(04 September 2008); doi:10.1038/nature07187
| Summary | Full Text (HTML / PDF) |
article
Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner
Colin K. Choi et al.
Nature Cell Biology 10, 1039–1050
(September 2008); doi:10.1038/ncb1763
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letter
The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory
Min Li et al.
Nature Cell Biology 10, 1083–1089
(September 2008); doi:10.1038/ncb1768
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review
Diversity of degradation signals in the ubiquitin–proteasome system
Tommer Ravid & Mark Hochstrasser
Nature Reviews Molecular Cell Biology 9, 679–689
(September 2008); doi:10.1038/nrm2468
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article
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
Olga Ananieva et al.
Nature Immunology 9, 1028–1036
(September 2008); doi:10.1038/ni.1644
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article
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
Robert J Snelgrove et al.
Nature Immunology 9, 1074–1083
(September 2008); doi:10.1038/ni.1637
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news and views
The CD200-CD200R axis in local control of lung inflammation
Patrick G Holt & Deborah H Strickland
Nature Immunology 9, 1011–1013
(September 2008); doi:10.1038/ni0908-1011
| Full Text (HTML / PDF) |
review
Vitamin effects on the immune system: vitamins A and D take centre stage
J. Rodrigo Mora, Makoto Iwata & Ulrich H. von Andrian
Nature Reviews Immunology 8, 685–698
(September 2008); doi:10.1038/nri2378
| Summary | Full Text (HTML / PDF) |
progress
Structural comparisons of class I phosphoinositide 3-kinases
L. Mario Amzel et al.
Nature Reviews Cancer 8, 665–669
(September 2008); doi:10.1038/nrc2443
| Summary | Full Text (HTML / PDF) |
article
Max-independent functions of Myc in Drosophila melanogaster
Dominik Steiger, Michael Furrer, Daniela Schwinkendorf & Peter Gallant
Nature Genetics 40, 1084–1091
(September 2008); doi:10.1038/ng.178
| Summary | Full Text (HTML / PDF) |
review
Towards a cyberinfrastructure for the biological sciences: progress, visions and challenges
Lincoln D. Stein
Nature Reviews Genetics 9, 678–688
(September 2008); doi:10.1038/nrg2414
| Summary | Full Text (HTML / PDF) |
article
Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors
Clara L Essmann et al.
Nature Neuroscience 11, 1035–1043
(September 2008); doi:10.1038/nn.2171
| Summary | Full Text (HTML / PDF) |
article
Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence
Kristin L Eckel-Mahan et al.
Nature Neuroscience 11, 1074–1082
(September 2008); doi:10.1038/nn.2174
| Summary | Full Text (HTML / PDF) |
news and views
Rhythms of memory
Tania L Roth & J David Sweatt
Nature Neuroscience 11, 993–994
(September 2008); doi:10.1038/nn0908-993
| Full Text (HTML / PDF) |
article
High-throughput, quantitative analyses of genetic interactions in E. coli
Athanasios Typas et al.
Nature Methods 5, 781–787
(September 2008); doi:10.1038/nmeth.1240
| Summary | Full Text (HTML / PDF) |
article
eSGA: E. coli synthetic genetic array analysis
Gareth Butland et al.
Nature Methods 5, 789–795
(September 2008); doi:10.1038/nmeth.1239
| Summary | Full Text (HTML / PDF) |
news and views
Sex to the rescue
Thomas J Silhavy & Zemer Gitai
Nature Methods 5, 759–760
(September 2008); doi:10.1038/nmeth0908-759
| Full Text (HTML / PDF) |
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