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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille & Michael L. Cleary
Nature 455, 1205–1209
(30 October 2008); doi:10.1038/nature07284
| Summary | Full Text (HTML / PDF) |
article
TMEM16A confers receptor-activated calcium-dependent chloride conductance
Young Duk Yang et al.
Nature 455, 1210–1215
(30 October 2008); doi:10.1038/nature07313
| Summary | Full Text (HTML / PDF) |
article
Activity-dependent regulation of inhibitory synapse development by Npas4
Yingxi Lin et al.
Nature 455, 1198–1204
(30 October 2008); doi:10.1038/nature07319
| Summary | Full Text (HTML / PDF) |
letter
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson & James A. Huntington
Nature 455, 1255–1258
(30 October 2008); doi:10.1038/nature07394
| Summary | Full Text (HTML / PDF) |
news and views
Structural biology: Serpins' mystery solved
James C. Whisstock & Stephen P. Bottomley
Nature 10, 1189–1190
(30 October 2008); doi:10.1038/4551189a
| Full Text (HTML / PDF) |
letter
ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis
Xianwu Zheng et al.
Nature 455, 1259–1262
(30 October 2008); doi:10.1038/nature07305
| Summary | Full Text (HTML / PDF) |
article
Proof-by-synthesis of the transcriptional logic of mammalian circadian clocks
Maki Ukai-Tadenuma, Takeya Kasukawa & Hiroki R. Ueda
Nature Cell Biology 10, 1154–1163
(October 2008); doi:10.1038/ncb1775
| Summary | Full Text (HTML / PDF) |
letter
d-Asb11 is an essential mediator of canonical Delta—Notch signalling
Sander H. Diks et al.
Nature Cell Biology 10, 1190–1198
(October 2008); doi:10.1038/ncb1779
| Summary | Full Text (HTML / PDF) |
letter
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly
Takbum Ohn, Nancy Kedersha, Tyler Hickman, Sarah Tisdale & Paul Anderson
Nature Cell Biology 10, 1224–1231
(October 2008); doi:10.1038/ncb1783
| Summary | Full Text (HTML / PDF) |
news and views
Stressed out? Make some modifications!
Angela Hilliker & Roy Parker
Nature Cell Biology 10, 1129–1130
(October 2008); doi:10.1038/ncb1008-1129
| Full Text (HTML / PDF) |
review
Phagosome maturation: going through the acid test
Jason M. Kinchen & Kodi S. Ravichandran
Nature Reviews Molecular Cell Biology 9, 781–795
(October 2008); doi:10.1038/nrm2515
| Summary | Full Text (HTML / PDF) |
article
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll
Laure El Chamy, Vincent Leclerc, Isabelle Caldelari & Jean-Marc Reichhart
Nature Immunology 9, 1165–1170
(October 2008); doi:10.1038/ni.1643
| Summary | Full Text (HTML / PDF) |
review
The alliance of sphingosine-1-phosphate and its receptors in immunity
Juan Rivera, Richard L. Proia & Ana Olivera
Nature Reviews Immunology 8, 753–763
(October 2008); doi:10.1038/nri2400
| Summary | Full Text (HTML / PDF) |
article
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Przemyslaw Sapieha et al.
Nature Medicine 14, 1067–1076
(October 2008); doi:10.1038/nm.1873
| Summary | Full Text (HTML / PDF) |
review
The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
Kay F. Macleod
Nature Reviews Cancer 8, 769–781
(October 2008); doi:10.1038/nrc2504
| Summary | Full Text (HTML / PDF) |
perspective
Replication licensing and cancer — a fatal entanglement?
J. Julian Blow & Peter J. Gillespie
Nature Reviews Cancer 8, 799–806
(October 2008); doi:10.1038/nrc2500
| Summary | Full Text (HTML / PDF) |
analysis
MicroRNAs in the Hox network: an apparent link to posterior prevalence
Soraya Yekta, Clifford J. Tabin & David P. Bartel
Nature Reviews Genetics 9, 789–796
(October 2008); doi:10.1038/nrg2400
| Summary | Full Text (HTML / PDF) |
review
CART peptides: regulators of body weight, reward and other functions
G. Rogge, D. Jones, G. W. Hubert, Y. Lin & M. J. Kuhar
Nature Reviews Neuroscience 9, 747–758
(October 2008); doi:10.1038/nrn2493
| Summary | Full Text (HTML / PDF) |
review
Next-generation DNA sequencing
Jay Shendure & Hanlee Ji
Nature Biotechnology 26, 1135–1145
(October 2008); doi:10.1038/nbt1486
| Summary | Full Text (HTML / PDF) |
review
The IL-33/ST2 pathway: therapeutic target and novel biomarker
Rahul Kakkar & Richard T. Lee
Nature Reviews Drug Discovery 7, 827–840
(October 2008); doi:10.1038/nrd2660
| Summary | Full Text (HTML / PDF) |
article
Activation of tyrosine kinases by mutation of the gatekeeper threonine
Mohammad Azam, Markus A Seeliger, Nathanael S Gray, John Kuriyan & George Q Daley
Nature Structural & Molecular Biology 15, 1109–1118
(October 2008); doi:10.1038/nsmb.1486
| Summary | Full Text (HTML / PDF) |
brief communication
Imaging individual mRNA molecules using multiple singly labeled probes
Arjun Raj, Patrick van den Bogaard, Scott A Rifkin, Alexander van Oudenaarden & Sanjay Tyagi
Nature Methods 5, 877–879
(October 2008); doi:10.1038/nmeth.1253
| Summary | Full Text (HTML / PDF) |
article
A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P2
Avia Rosenhouse-Dantsker et al.
Nature Chemical Biology 4, 624–631
(October 2008); doi:10.1038/nchembio.112
| Summary | Full Text (HTML / PDF) |
article
Autonomous onset of the circadian clock in the zebrafish embryo
Marcus P S Dekens and David Whitmore
The EMBO Journal 27, 2757–2765
(October 2008); doi:10.1038/emboj.2008.183
| Summary | Full Text (HTML / PDF) |
review
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer
Pascal Descargues, Alok K Sil and Michael Karin
The EMBO Journal 27, 2639–2647
(October 2008); doi:10.1038/emboj2008196a
| Summary | Full Text (HTML / PDF) |
article
BAX activation is initiated at a novel interaction site
Evripidis Gavathiotis et al.
Nature 455, 1076–1081
(23 October 2008); doi:10.1038/nature07396
| Summary | Full Text (HTML / PDF) |
news and views
Apoptosis: Stabbed in the BAX
Douglas R. Green & Jerry E. Chipuk
Nature 455, 1047–1049
(23 October 2008); doi:10.1038/4551047a
| Full Text (HTML / PDF) |
article
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding et al.
Nature 455, 1069–1075
(23 October 2008); doi:10.1038/nature07423
| Summary | Full Text (HTML / PDF) |
article
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network
Nature 455, 1061–1068
(23 October 2008); doi:10.1038/nature07385
| Summary | Full Text (HTML / PDF) |
letter
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
Hongwu Zheng et al.
Nature 455, 1129–1133
(23 October 2008); doi:10.1038/nature07443
| Summary | Full Text (HTML / PDF) |
letter
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen et al.
Nature 455, 1109–1113
(23 October 2008); doi:10.1038/nature07336
| Summary | Full Text (HTML / PDF) |
letter
Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
Guonan Lin, Na Xu & Rongwen Xi
Nature 455, 1119–1123
(23 October 2008); doi:10.1038/nature07329
| Summary | Full Text (HTML / PDF) |
letter
Control of plant germline proliferation by SCFFBL17 degradation of cell cycle inhibitors
Hyo Jung Kim et al.
Nature 455, 1134–1137
(23 October 2008); doi:10.1038/nature07289
| Summary | Full Text (HTML / PDF) |
article
A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance
Jia-Shu Yang et al.
Nature Cell Biology 10, 1146–1153
(October 2008); doi:10.1038/ncb1774
| Summary | Full Text (HTML / PDF) |
letter
Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL
Vipul C. Chitalia et al.
Nature Cell Biology 10, 1208–1216
(October 2008); doi:10.1038/ncb1781
| Summary | Full Text (HTML / PDF) |
news and views
One hit, two outcomes for VHL-mediated tumorigenesis
Jürgen Behrens
Nature Cell Biology 10, 1127–1128
(October 2008); doi:10.1038/ncb1008-1127
| Full Text (HTML / PDF) |
review
Modelling and analysis of gene regulatory networks
Guy Karlebach & Ron Shamir
Nature Reviews Molecular Cell Biology 9, 770–780
(October 2008); doi:10.1038/nrm2503
| Summary | Full Text (HTML / PDF) |
article
Mincle is an ITAM-coupled activating receptor that senses damaged cells
Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Hiromitsu Hara, Koji Ogata & Takashi Saito
Nature Immunology 9, 1179–1188
(October 2008); doi:10.1038/ni.1651
| Summary | Full Text (HTML / PDF) |
news and views
Sensing necrosis with Mincle
Gordon D Brown
Nature Immunology 9, 1099–1100
(October 2008); doi:10.1038/ni1008-1099
| Full Text (HTML / PDF) |
article
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
Judith N. Mandl et al.
Nature Medicine 14, 1077–1087
(October 2008); doi:10.1038/nm.1871
| Summary | Full Text (HTML / PDF) |
news and views
Immune alteration fends off AIDS
Karen O'Connell & Robert F Siliciano
Nature Medicine 14, 1016–1018
(October 2008); doi:10.1038/nm1008-1016
| Full Text (HTML / PDF) |
review
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Jane E. Visvader & Geoffrey J. Lindeman
Nature Reviews Cancer 8 755–768
(October 2008); doi:10.1038/nrc2499
| Summary | Full Text (HTML / PDF) |
letter
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
Minh D To, Christine E Wong, Anthony N Karnezis, Reyno Del Rosario, Roberto Di Lauro & Allan Balmain
Nature Genetics 40, 1240–1244
(October 2008); doi:10.1038/ng.211
| Summary | Full Text (HTML / PDF) |
news and views
Kras and Hras—what is the difference?
Anton Berns
Nature Genetics 40, 1149–1150
(October 2008); doi:10.1038/ng1008-1149
| Full Text (HTML / PDF) |
article
Notch signaling respecifies the hemangioblast to a cardiac fate
Vincent C Chen, Robert Stull, Daniel Joo, Xin Cheng & Gordon Keller
Nature Biotechnology 26, 1169–1178
(October 2008); doi:10.1038/nbt.1497
| Summary | Full Text (HTML / PDF) |
review
The potential and challenges of nanopore sequencing
Daniel Branton et al.
Nature Biotechnology 26 1146–1153
(October 2008); doi:10.1038/nbt.1495
| Summary | Full Text (HTML / PDF) |
article
TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway
Marc Bühler, Noah Spies, David P Bartel & Danesh Moazed
Nature Structural & Molecular Biology 15, 1015–1023
(October 2008); doi:10.1038/nsmb.1481
| Summary | Full Text (HTML / PDF) |
news and views
Competing to destroy: a fight between two RNA-degradation systems
Geneviève Thon
Nature Structural & Molecular Biology 15, 1001–1002
(October 2008); doi:10.1038/nsmb1008-1001
| Full Text (HTML / PDF) |
article
Mapping a molecular link between allosteric inhibition and activation of the glycine receptor
Paul S Miller, Maya Topf & Trevor G Smart
Nature Structural & Molecular Biology 15, 1084–1093
(October 2008); doi:10.1038/nsmb.1492
| Summary | Full Text (HTML / PDF) |
article
Optogenetic analysis of synaptic function
Jana F Liewald et al.
Nature Methods 5, 895–902
(October 2008); doi:10.1038/nmeth.1252
| Summary | Full Text (HTML / PDF) |
article
Identification of ALK as a major familial neuroblastoma predisposition gene
Yaël P. Mossé et al.
Nature 455, 930–935
(16 October 2008); doi:10.1038/nature07261
| Summary | Full Text (HTML / PDF) |
letter
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix-Lerosey et al.
Nature 455, 967–970
(16 October 2008); doi:10.1038/nature07398
| Summary | Full Text (HTML / PDF) |
letter
Oncogenic mutations of ALK kinase in neuroblastoma
Yuyan Chen et al.
Nature 455, 971–974
(16 October 2008); doi:10.1038/nature07399
| Summary | Full Text (HTML / PDF) |
letter
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George et al.
Nature 455, 975–978
(16 October 2008); doi:10.1038/nature07397
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: A ringleader identified
Charis Eng
Nature 455, 883–884
(16 October 2008); doi:10.1038/455883a
| Full Text (HTML / PDF) |
letter
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
Jason S. McLellan, Xiaoyan Zheng, Glenn Hauk, Rodolfo Ghirlando, Philip A. Beachy & Daniel J. Leahy
Nature 455, 979–983
(16 October 2008); doi:10.1038/nature07358
| Summary | Full Text (HTML / PDF) |
letter
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
Xian-Ping Dong et al.
Nature 455, 992–996
(16 October 2008); doi:10.1038/nature07311
| Summary | Full Text (HTML / PDF) |
article
GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus
Yusuke Maeda, Toru Ide, Masato Koike, Yasuo Uchiyama & Taroh Kinoshita
Nature Cell Biology 10, 1135–1145
(October 2008); doi:10.1038/ncb1773
| Summary | Full Text (HTML / PDF) |
news and views
Pores galore for the Golgi
John H. Caldwell & Kathryn E. Howell
Nature Cell Biology 10, 1125–1126
(October 2008); doi:10.1038/ncb1008-1125
| Full Text (HTML / PDF) |
letter
Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis
Sara Geraldo, Umme K. Khanzada, Maddy Parsons, John K. Chilton & Phillip R. Gordon-Weeks
Nature Cell Biology 10, 1181–1189
(October 2008); doi:10.1038/ncb1778
| Summary | Full Text (HTML / PDF) |
review
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Martin F. Lavin
Nature Reviews Molecular Cell Biology 9, 759–769
(October 2008); doi:10.1038/nrm2514
| Summary | Full Text (HTML / PDF) |
perspective
Transcription-independent functions of MYC: regulation of translation and DNA replication
Michael D. Cole & Victoria H. Cowling
Nature Reviews Molecular Cell Biology 9, 810–815
(October 2008); doi:10.1038/nrm2467
| Summary | Full Text (HTML / PDF) |
article
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
Yoichi Maekawa et al.
Nature Immunology 9, 1140–1147
(October 2008); doi:10.1038/ni.1649
| Summary | Full Text (HTML / PDF) |
article
Toll-like receptor—mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
Weiping Cao et al.
Nature Immunology 9, 1157–1164
(October 2008); doi:10.1038/ni.1645
| Summary | Full Text (HTML / PDF) |
news and views
RAPping production of type I interferon in pDCs through mTOR
Mauro Costa-Mattioli & Nahum Sonenberg
Nature Immunology 9, 1097–1099
(October 2008); doi:10.1038/ni1008-1097
| Full Text (HTML / PDF) |
review
Harmful molecular mechanisms in sepsis
Daniel Rittirsch, Michael A. Flierl & Peter A. Ward
Nature Reviews Immunology 8, 776–787
(October 2008); doi:10.1038/nri2402
| Summary | Full Text (HTML / PDF) |
letter
The Creb1 coactivator Crtc1 is required for energy balance and fertility
Judith Y Altarejos et al.
Nature Medicine 14, 1112–1117
(October 2008); doi:10.1038/nm.1866
| Summary | Full Text (HTML / PDF) |
perspective
Bone morphogenetic protein signalling in colorectal cancer
James C. Hardwick, Liudmila L. Kodach, G. Johan Offerhaus & Gijs R. van den Brink
Nature Reviews Cancer 8, 806–812
(October 2008); doi:10.1038/nrc2467
| Summary | Full Text (HTML / PDF) |
review
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Joseph S. Takahashi, Hee-Kyung Hong, Caroline H. Ko & Erin L. McDearmon
Nature Reviews Genetics 9, 764–775
(October 2008); doi:10.1038/nrg2430
| Summary | Full Text (HTML / PDF) |
review
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Lars Bertram & Rudolph E. Tanzi
Nature Reviews Neuroscience 9, 768–778
(October 2008); doi:10.1038/nrn2494
| Summary | Full Text (HTML / PDF) |
perspective
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
Markus J Herrgård et al.
Nature Biotechnology 26, 1155–1160
(October 2008); doi:10.1038/nbt1492
| Summary | Full Text (HTML / PDF) |
review
Sirtuins — novel therapeutic targets to treat age-associated diseases
Siva Lavu, Olivier Boss, Peter J. Elliott & Philip D. Lambert
Nature Reviews Drug Discovery 7, 841–853
(October 2008); doi:10.1038/nrd2665
| Summary | Full Text (HTML / PDF) |
article
Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3
Xin Geng et al.
Nature Structural & Molecular Biology 15, 1094–1101
(October 2008); doi:10.1038/nsmb.1488
| Summary | Full Text (HTML / PDF) |
article
SAP-controlled T–B cell interactions underlie germinal centre formation
Hai Qi, Jennifer L. Cannons, Frederick Klauschen, Pamela L. Schwartzberg & Ronald N. Germain
Nature 455, 764–769
(9 October 2008); doi:10.1038/nature07345
| Summary | Full Text (HTML / PDF) |
news and views
Immunology: Helpful T cells are sticky
Elissa K. Deenick & Stuart G. Tangye
Nature 455, 745–747
(9 October 2008); doi:10.1038/455745a
| Full Text (HTML / PDF) |
article
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
Eleni P. Mimitou & Lorraine S. Symington
Nature 455, 770–774
(9 October 2008); doi:10.1038/nature07312
| Summary | Full Text (HTML / PDF) |
news and views
Molecular biology: DNA endgames
Hannah L. Klein
Nature 455, 740–741
(9 October 2008); doi:10.1038/455740a
| Full Text (HTML / PDF) |
letter
The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
Min Sup Song et al.
Nature 455, 813–817
(9 October 2008); doi:10.1038/nature07290
| Summary | Full Text (HTML / PDF) |
letter
Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes
Daisuke Satoh et al.
Nature Cell Biology 10, 1164–1171
(October 2008); doi:10.1038/ncb1776
| Summary | Full Text (HTML / PDF) |
letter
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons
Yi Zheng et al.
Nature Cell Biology 10, 1172–1180
(October 2008); doi:10.1038/ncb1777
| Summary | Full Text (HTML / PDF) |
news and views
Dynein branches out
Guy Tear
Nature Cell Biology 10, 1131–1132
(October 2008); doi:10.1038/ncb1008-1131
| Full Text (HTML / PDF) |
letter
The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
Alessandro Sorrentino et al.
Nature Cell Biology 10, 1199–1207
(October 2008); doi:10.1038/ncb1780
| Summary | Full Text (HTML / PDF) |
perspective
Is there a code embedded in proteins that is based on post-translational modifications?
Robert J. Sims 3rd & Danny Reinberg
Nature Reviews Molecular Cell Biology 9, 815–820
(October 2008); doi:10.1038/nrm2502
| Summary | Full Text (HTML / PDF) |
article
The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells
Gaëtan Barbet et al.
Nature Immunology 9, 1148–1156
(October 2008); doi:10.1038/ni.1648
| Summary | Full Text (HTML / PDF) |
perspective
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways
Lionel B. Ivashkiv
Nature Reviews Immunology 8, 816–822
(October 2008); doi:10.1038/nri2396
| Summary | Full Text (HTML / PDF) |
article
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
Robert L Wilensky et al.
Nature Medicine 14, 1059–1066
(October 2008); doi:10.1038/nm.1870
| Summary | Full Text (HTML / PDF) |
news and views
Getting to the core of atherosclerosis
Nancy R Webb
Nature Medicine 14, 1015–1016
(October 2008); doi:10.1038/nm1008-1015
| Full Text (HTML / PDF) |
review
Basal cell carcinomas: attack of the hedgehog
Ervin H. Epstein
Nature Reviews Cancer 8, 743–754
(October 2008); doi:10.1038/nrc2503
| Summary | Full Text (HTML / PDF) |
letter
A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse
Edward E Patterson et al.
Nature Genetics 40, 1235–1239
(October 2008); doi:10.1038/ng.224
| Summary | Full Text (HTML / PDF) |
brief communication
ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval
Alina Elkobi, Ingrid Ehrlich, Katya Belelovsky, Liza Barki-Harrington & Kobi Rosenblum
Nature Neuroscience 11, 1149–1151
(October 2008); doi:10.1038/nn.2190
| Summary | Full Text (HTML / PDF) |
article
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
Joshua Munger et al.
Nature Biotechnology 26, 1179–1186
(October 2008); doi:10.1038/nbt.1500
| Summary | Full Text (HTML / PDF) |
news and views
From biomarkers to integrated network responses
Uwe Sauer & Nicola Zamboni
Nature Biotechnology 26, 1090–1092
(October 2008); doi:10.1038/nbt1008-1090
| Full Text (HTML / PDF) |
article
Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS
Manuel Etzkorn et al.
Nature Structural & Molecular Biology 15, 1031–1039
(October 2008); doi:10.1038/nsmb.1493
| Summary | Full Text (HTML / PDF) |
brief communication
A torque component present in mitotic kinesin Eg5 revealed by three-dimensional tracking
Junichiro Yajima, Kana Mizutani & Takayuki Nishizaka
Nature Structural & Molecular Biology 15, 1119–1121
(October 2008); doi:10.1038/nsmb.1491
| Summary | Full Text (HTML / PDF) |
review
Chemical probes for histone-modifying enzymes
Philip A Cole
Nature Chemical Biology 4, 590–597
(October 2008); doi:10.1038/nchembio.111
| Summary | Full Text (HTML / PDF) |
article
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Qiao Zhou, Juliana Brown, Andrew Kanarek, Jayaraj Rajagopal & Douglas A. Melton
Nature 455, 627–632
(2 October 2008); doi:10.1038/nature07314
| Summary | Full Text (HTML / PDF) |
news and views
Regenerative medicine: Short cut to cell replacement
Robert Blelloch
Nature 455, 604–605
(2 October 2008); doi:10.1038/455604a;
| Full Text (HTML / PDF) |
letter
UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites
Vivian Y. Poon, Matthew P. Klassen & Kang Shen
Nature 455, 669–673
(2 October 2008); doi:10.1038/nature07291
| Summary | Full Text (HTML / PDF) |
letter
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Hiroki Ishikawa & Glen N. Barber
Nature 455, 674–678
(2 October 2008); doi:10.1038/nature07317
| Summary | Full Text (HTML / PDF) |
letter
Modelling Myc inhibition as a cancer therapy
Laura Soucek et al.
Nature 455, 679–683
(2 October 2008); doi:10.1038/nature07260
| Summary | Full Text (HTML / PDF) |
letter
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation
Valentina Gandin et al.
Nature 455, 684–688
(2 October 2008); doi:10.1038/nature07267
| Summary | Full Text (HTML / PDF) |
letter
CDK targets Sae2 to control DNA-end resection and homologous recombination
Pablo Huertas, Felipe Cortés-Ledesma, Alessandro A. Sartori, Andrés Aguilera & Stephen P. Jackson
Nature 455, 689–692
(2 October 2008); doi:10.1038/nature07215
| Summary | Full Text (HTML / PDF) |
review
The RSK family of kinases: emerging roles in cellular signalling
Rana Anjum & John Blenis
Nature Reviews Molecular Cell Biology 9, 747–758
(October 2008); doi:10.1038/nrm2509
| Summary | Full Text (HTML / PDF) |
article
Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
Sawako Muroi et al.
Nature Immunology 9, 1113–1121
(October 2008); doi:10.1038/ni.1650
| Summary | Full Text (HTML / PDF) |
article
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells
Lie Wang et al.
Nature Immunology 9, 1122–1130
(October 2008); doi:10.1038/ni.1647
| Summary | Full Text (HTML / PDF) |
article
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
Takeshi Egawa & Dan R Littman
Nature Immunology 9, 1131–1139
(October 2008); doi:10.1038/ni.1652
| Summary | Full Text (HTML / PDF) |
news and views
Putting ThPOK in place
J Jeremiah Bell & Avinash Bhandoola
Nature Immunology 9, 1095–1096
(October 2008); doi:10.1038/ni1008-1095;
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review
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Ricky W. Johnstone, Ailsa J. Frew & Mark J. Smyth
Nature Reviews Cancer 8, 782–798
(October 2008); doi:10.1038/nrc2465
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brief communication
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity
Thomas Müller et al.
Nature Genetics 40, 1163–1165
(October 2008); doi:10.1038/ng.225
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perspective
Trends in large-scale mouse mutagenesis: from genetics to functional genomics
Yoichi Gondo
Nature Reviews Genetics 9, 803–810
(October 2008); doi:10.1038/nrg2431
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review
The insulin paradox: aging, proteotoxicity and neurodegeneration
Ehud Cohen & Andrew Dillin
Nature Reviews Neuroscience 9, 759–767
(October 2008); doi:10.1038/nrn2474
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article
Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering
Marco Cammarata et al.
Nature Methods 5, 881–886
(October 2008); doi:10.1038/nmeth.1255
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