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December 2008
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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation
Rujun Kang et al.
Nature 456, 904–909
(18 December 2008); doi:10.1038/nature07605
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news and views
Neuroscience: Greasy proteins of the neuron
Maurine E. Linder
Nature 456, 887–888
(18 December 2008); doi:10.1038/456887a
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article
SUMOylation regulates Rad18-mediated template switch
Dana Branzei, Fabio Vanoli & Marco Foiani
Nature 456, 915–920
(18 December 2008); doi:10.1038/nature07587
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letter
Contact inhibition of locomotion in vivo controls neural crest directional migration
Carlos Carmona-Fontaine et al.
Nature 456, 957–961
(18 December 2008); doi:10.1038/nature07441
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letter
Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions
Pankaj Dhonukshe et al.
Nature 456, 962–966
(18 December 2008); doi:10.1038/nature07409
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letter
G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling
Stacey K. Ogden et al.
Nature 456, 967–970
(18 December 2008); doi:10.1038/nature07459
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letter
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
Maria Barna et al.
Nature 456, 971–975
(18 December 2008); doi:10.1038/nature07449
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letter
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex
Bernard T. Kelly et al.
Nature 456, 976–979
(18 December 2008); doi:10.1038/nature07422
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letter
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum et al.
Nature 456, 980–984
(18 December 2008); doi:10.1038/nature07511
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letter
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology
Theresa Alenghat et al.
Nature 456, 997–1000
(18 December 2008); doi:10.1038/nature07541
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news and views
Circadian clocks: Tips from the tip of the iceberg
Fred W. Turek
Nature 456, 881–883
(18 December 2008); doi:10.1038/456881a
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article
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
Jakob Nilsson, Mona Yekezare, Jeremy Minshull & Jonathon Pines
Nature Cell Biology 10, 1411–1420
(December 2008); doi:10.1038/ncb1799
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news and views
Under arrest in mitosis: Cdc20 dies twice
Andrew M. Fry & Hiroyuki Yamano
Nature Cell Biology 10, 1385–1387
(December 2008); doi:10.1038/ncb1208-1385
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letter
Activation of TGF-β/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts
Naohiro Kon et al.
Nature Cell Biology 10, 1463–1469
(December 2008); doi:10.1038/ncb1806
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review
Design principles of biochemical oscillators
Béla Novák & John J. Tyson
Nature Reviews Molecular Cell Biology 9, 981–991
(December 2008); doi:10.1038/nrm2530
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perspective
Autophagic cell death: the story of a misnomer
Guido Kroemer & Beth Levine
Nature Reviews Molecular Cell Biology 9, 1004–1010
(December 2008); doi:10.1038/nrm2529
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article
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
Sivakumar Vallabhapurapu et al.
Nature Immunology 9, 1364–1370
(December 2008); doi:10.1038/ni.1678
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article
Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
Brian J Zarnegar et al.
Nature Immunology 9, 1371–1378
(December 2008); doi:10.1038/ni.1676
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news and views
Self-termination of the terminator
David Wallach & Andrew Kovalenko
Nature Immunology 9, 1325–1327
(December 2008); doi:10.1038/ni1208-1325
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article
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
Karim C El Kasmi et al.
Nature Immunology 9, 1399–1406
(December 2008); doi:10.1038/ni.1671
| Summary | Full Text (HTML / PDF) |
review
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
Pärt Peterson, Tõnis Org & Ana Rebane
Nature Reviews Immunology 8, 948–957
(December 2008); doi:10.1038/nri2450
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article
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Rihab Nasr et al.
Nature Medicine 14, 1333–1342
(December 2008); doi:10.1038/nm.1891
| Summary | Full Text (HTML / PDF) |
letter
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A Engelman et al.
Nature Medicine 14, 1351–1356
(December 2008); doi:10.1038/nm.1890
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news and views
Targeting RAS and PI3K in lung cancer
Julian Downward
Nature Medicine 14, 1315–1316
(December 2008); doi:10.1038/nm1208-1315
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review
The ADAMs: signalling scissors in the tumour microenvironment
Gillian Murphy
Nature Reviews Cancer 8, 932–941
(December 2008); doi:10.1038/nrc2459
| Summary | Full Text (HTML / PDF) |
letter
Embryonic stem cell—specific microRNAs regulate the G1-S transition and promote rapid proliferation
Yangming Wang et al.
Nature Genetics 40, 1478–1483
(December 2008); doi:10.1038/ng.250
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news and views
Cell cycle micromanagement in embryonic stem cells
V Narry Kim
Nature Genetics 40, 1391–1392
(December 2008); doi:10.1038/ng1208-1391
| Full Text (HTML / PDF) |
review
Epigenetic regulation of centromeric chromatin: old dogs, new tricks?
Robin C. Allshire & Gary H. Karpen
Nature Reviews Genetics 9, 923–937
(December 2008); doi:10.1038/nrg2466
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article
FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity
Marc Flajolet et al.
Nature Neuroscience 11, 1402–1409
(December 2008); doi:10.1038/nn.2216
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review
VPS10P-domain receptors — regulators of neuronal viability and function
Thomas E. Willnow, Claus M. Petersen & Anders Nykjaer
Nature Reviews Neuroscience 9, 899–909
(December 2008); doi:10.1038/nrn2516
| Summary | Full Text (HTML / PDF) |
research
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
Jürgen Cox & Matthias Mann
Nature Biotechnology 26, 1367–1372
(December 2008); doi:10.1038/nbt.1511
| Summary | Full Text (HTML / PDF) |
perspective
The genetics of the p53 pathway, apoptosis and cancer therapy
Alexei Vazquez, Elisabeth E. Bond, Arnold J. Levine & Gareth L. Bond
Nature Reviews Drug Discovery 7, 979–987
(December 2008); doi:10.1038/nrd2656
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article
Molecular basis of Pirh2-mediated p53 ubiquitylation
Yi Sheng et al.
Nature Structural & Molecular Biology 15, 1334–1342
(December 2008); doi:10.1038/nsmb.1521
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article
Single-RNA counting reveals alternative modes of gene expression in yeast
Daniel Zenklusen, Daniel R Larson & Robert H Singer
Nature Structural & Molecular Biology 15, 1263–1271
(December 2008); doi:10.1038/nsmb.1514
| Summary | Full Text (HTML / PDF) |
review
From bench to bedside: stealth of enteroinvasive pathogens
Renée M. Tsolis, Glenn M. Young, Jay V. Solnick & Andreas J. Bäumler
Nature Reviews Microbiology 6, 883–892
(December 2008); doi:10.1038/nrmicro2012
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article
Micropatterning for quantitative analysis of protein-protein interactions in living cells
Michaela Schwarzenbacher et al.
Nature Methods 5, 1053–1060
(December 2008); doi:10.1038/nmeth.1268
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article
Negative feedback that improves information transmission in yeast signalling
Richard C. Yu et al.
Nature 456, 755–761
(11 December 2008); doi:10.1038/nature07513
| Summary | Full Text (HTML / PDF) |
letter
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Joshua I. Greenberg et al.
Nature 456, 809–813
(11 December 2008); doi:10.1038/nature07424
| Summary | Full Text (HTML / PDF) |
letter
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Christian Stockmann et al.
Nature 456, 814–818
(11 December 2008); doi:10.1038/nature07445
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article
Arginine methylation regulates the p53 response
Martin Jansson et al.
Nature Cell Biology 10, 1431–1439
(December 2008); doi:10.1038/ncb1802
| Summary | Full Text (HTML / PDF) |
news and views
Out of the jaws of death: PRMT5 steers p53
Shelley L. Berger
Nature Cell Biology 10, 1389–1390
(December 2008); doi:10.1038/ncb1208-1389
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article
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells
Thomas F.J. Wagner et al.
Nature Cell Biology 10, 1421–1430
(December 2008); doi:10.1038/ncb1801
| Summary | Full Text (HTML / PDF) |
news and views
A TRP channel-steroid marriage
Bernd Nilius & Thomas Voets
Nature Cell Biology 10, 1383–1384
(December 2008); doi:10.1038/ncb1208-1383
| Full Text (HTML / PDF) |
review
Fluorescent probes for super-resolution imaging in living cells
Marta Fernández-Suárez & Alice Y. Ting
Nature Reviews Molecular Cell Biology 9, 929–943
(December 2008); doi:10.1038/nrm2531
| Summary | Full Text (HTML / PDF) |
article
Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset
Marc Veldhoen et al.
Nature Immunology 9, 1341–1346
(December 2008); doi:10.1038/ni.1659
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article
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
Boyoun Park et al.
Nature Immunology 9, 1407–1414
(December 2008); doi:10.1038/ni.1669
| Summary | Full Text (HTML / PDF) |
review
Viral evasion and subversion of pattern-recognition receptor signalling
Andrew G. Bowie & Leonie Unterholzner
Nature Reviews Immunology 8, 911–922
(December 2008); doi:10.1038/nri2436
| Summary | Full Text (HTML / PDF) |
article
Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex
Xue Jun Liu et al.
Nature Medicine 14, 1325–1332
(December 2008); doi:10.1038/nm.1883
| Summary | Full Text (HTML / PDF) |
news and views
Breaking the pain connection
Catherine J Pallen
Nature Medicine 14, 1313–1315
(December 2008); doi:10.1038/nm1208-1313
| Full Text (HTML / PDF) |
letter
Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases
M Melina Soares, Steven W King & Philip E Thorpe
Nature Medicine 14, 1357–1362
(December 2008); doi:10.1038/nm.1885
| Summary | Full Text (HTML / PDF) |
letter
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
Shigeru Shibata et al.
Nature Medicine 14, 1370–1376
(December 2008); doi:10.1038/nm.1879
| Summary | Full Text (HTML / PDF) |
review
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
Christian Fischer, Massimiliano Mazzone, Bart Jonckx & Peter Carmeliet
Nature Reviews Cancer 8, 942–956
(December 2008); doi:10.1038/nrc2524
| Summary | Full Text (HTML / PDF) |
article
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
COGENT Study
Nature Genetics 40, 1426–1435
(December 2008); doi:10.1038/ng.262
| Summary | Full Text (HTML / PDF) |
article
GABAB receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses
Chun Xu, Man-xia Zhao, Mu-ming Poo & Xiao-hui Zhang
Nature Neuroscience 11, 1410–1418
(December 2008); doi:10.1038/nn.2215
| Summary | Full Text (HTML / PDF) |
Correspondence
PhosphoPep—a database of protein phosphorylation sites in model organisms
Bernd Bodenmiller et al.
Nature Biotechnology 26, 1339–1340
(December 2008); doi:10.1038/nbt1208-1339
| Summary | Full Text (HTML / PDF) |
review
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
Anwesha Dey, Vinay Tergaonkar & David P. Lane
Nature Reviews Drug Discovery 7, 1031–1040
(December 2008); doi:10.1038/nrd2759
| Summary | Full Text (HTML / PDF) |
review
Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
Avi Ashkenazi
Nature Reviews Drug Discovery 7, 1001–1012
(December 2008); doi:10.1038/nrd2637
| Summary | Full Text (HTML / PDF) |
article
Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin
Yoshihiro Dohi et al.
Nature Structural & Molecular Biology 15, 1246–1254
(December 2008); doi:10.1038/nsmb.1516
| Summary | Full Text (HTML / PDF) |
article
Structural insights into the Cyclin T1–Tat–TAR RNA transcription activation complex from EIAV
Kanchan Anand, Antje Schulte, Karin Vogel-Bachmayr, Klaus Scheffzek & Matthias Geyer
Nature Structural & Molecular Biology 15, 1287–1292
(December 2008); doi:10.1038/nsmb.1513
| Summary | Full Text (HTML / PDF) |
review
The curious case of the tumour virus: 50 years of Burkitt's lymphoma
David A. Thorley-Lawson & Martin J. Allday
Nature Reviews Microbiology 6, 913–924
(December 2008); doi:10.1038/nrmicro2015
| Summary | Full Text (HTML / PDF) |
article
Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution
Bo Huang, Sara A Jones, Boerries Brandenburg & Xiaowei Zhuang
Nature Methods 5, 1047–1052
(December 2008); doi:10.1038/nmeth.1274
| Summary | Full Text (HTML / PDF) |
article
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito & Luca Scorrano
Nature 456, 605–610
(04 December 2008); doi:10.1038/nature07534
| Summary | Full Text (HTML / PDF) |
letter
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
Sarah E. Ewald et al.
Nature 456, 658–662
(04 December 2008); doi:10.1038/nature07405
| Summary | Full Text (HTML / PDF) |
letter
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen
Antoni Hurtado et al.
Nature 456, 663–666
(04 December 2008); doi:10.1038/nature07483
| Summary | Full Text (HTML / PDF) |
letter
Regulation of the Drosophila apoptosome through feedback inhibition
Peter J. Shapiro, Hans H. Hsu, Heekyung Jung, Edith S. Robbins & Hyung Don Ryoo
Nature Cell Biology 10, 1440–1446
(December 2008); doi:10.1038/ncb1803
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news and views
Staying alive: apoptosome feedback inhibition
Hermann Steller
Nature Cell Biology 10, 1387–1388
(December 2008); doi:10.1038/ncb1208-1387
| Full Text (HTML / PDF) |
letter
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
Taner Dogan et al.
Nature Cell Biology 10, 1447–1455
(December 2008); doi:10.1038/ncb1804
| Summary | Full Text (HTML / PDF) |
letter
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
Allyson E. Vaughn & Mohanish Deshmukh
Nature Cell Biology 10, 1477–1483
(December 2008); doi:10.1038/ncb1807
| Summary | Full Text (HTML / PDF) |
review
Transcription-coupled DNA repair: two decades of progress and surprises
Philip C. Hanawalt & Graciela Spivak
Nature Reviews Molecular Cell Biology 9, 958–970
(December 2008); doi:10.1038/nrm2549
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article
Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling
Jason E Stadanlick et al.
Nature Immunology 9, 1379–1387
(December 2008); doi:10.1038/ni.1666
| Summary | Full Text (HTML / PDF) |
article
Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling
Trupti Kawli & Man-Wah Tan
Nature Immunology 9, 1415–1424
(December 2008); doi:10.1038/ni.1672
| Summary | Full Text (HTML / PDF) |
news and views
Nervous about immunity: neuronal signals control innate immune system
Cheng-Yuan Kao, Ferdinand C O Los & Raffi V Aroian
Nature Immunology 9, 1329–1330
(December 2008); doi:10.1038/ni1208-1329
| Full Text (HTML / PDF) |
review
Nutrient sensing and inflammation in metabolic diseases
Gökhan S. Hotamisligil & Ebru Erbay
Nature Reviews Immunology 8, 923–934
(December 2008); doi:10.1038/nri2449
| Summary | Full Text (HTML / PDF) |
perspective
Immunotherapy of autoimmunity and cancer: the penalty for success
Rachel R. Caspi
Nature Reviews Immunology 8, 970–976
(December 2008); doi:10.1038/nri2438
| Summary | Full Text (HTML / PDF) |
review
Insulin and insulin-like growth factor signalling in neoplasia
Michael Pollak
Nature Reviews Cancer 8, 915–928
(December 2008); doi:10.1038/nrc2536
| Summary | Full Text (HTML / PDF) |
article
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
Victoria Marsh et al.
Nature Genetics 40, 1436–1444
(December 2008); doi:10.1038/ng.256
| Summary | Full Text (HTML / PDF) |
article
β-catenin–mediated Wnt signaling regulates neurogenesis in the ventral telencephalon
Alexandra A Gulacsi & Stewart A Anderson
Nature Neuroscience 11, 1383–1391
(December 2008); doi:10.1038/nn.2226
| Summary | Full Text (HTML / PDF) |
review
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim, Wenjie Xu & John C. Reed
Nature Reviews Drug Discovery 7, 1013–1030
(December 2008); doi:10.1038/nrd2755
| Summary | Full Text (HTML / PDF) |
review
BCL-2 family antagonists for cancer therapy
Guillaume Lessene, Peter E. Czabotar & Peter M. Colman
Nature Reviews Drug Discovery 7, 989–1000
(December 2008); doi:10.1038/nrd2658
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article
Epitope mapping of antibodies using bacterial surface display
Johan Rockberg, John Löfblom, Barbara Hjelm, Mathias Uhlén & Stefan Ståhl
Nature Methods 5, 1039–1045
(December 2008); doi:10.1038/nmeth.1272
| Summary | Full Text (HTML / PDF) |
news and views
On display on a bug: a systematic approach to characterize antibodies
Thomas Knorpp & Markus F Templin
Nature Methods 5, 1003–1004
(December 2008); doi:10.1038/nmeth1208-1003
| Full Text (HTML / PDF) |
article
CD15 expression in human myeloid cell differentiation is regulated by sialidase activity
Samah Zeineb Gadhoum & Robert Sackstein
Nature Chemical Biology 4, 751–757
(December 2008); doi:10.1038/nchembio.116
| Summary | Full Text (HTML / PDF) |
news and views
Seeing cellular sialidase transform sugars
Minoru Fukuda & Xingfeng Bao
Nature Chemical Biology 4, 721–722
(December 2008); doi:10.1038/nchembio1208-721
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