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Research library: browse by date

January 2009

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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letter
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
Aurelien Trompette et al.
Nature 457, 585–588
(January 2009); doi:10.1038/nature07548
| Summary | Full Text (HTML / PDF) |

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WNT11 acts as a directional cue to organize the elongation of early muscle fibres
Jérôme Gros, Olivier Serralbo & Christophe Marcelle
Nature 457, 589–593
(January 2009); doi:10.1038/nature07564
| Summary | Full Text (HTML / PDF) |

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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Catherine D. Van Raamsdonk et al.
Nature 457, 599–602
(January 2009); doi:10.1038/nature07586
| Summary | Full Text (HTML / PDF) |

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RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light
Takashi Hishida, Yoshino Kubota, Antony M. Carr & Hiroshi Iwasaki
Nature 457, 612–615
(January 2009); doi:10.1038/nature07580
| Summary | Full Text (HTML / PDF) |

article
MG53 nucleates assembly of cell membrane repair machinery
Chuanxi Cai et al.
Nature Cell Biology 11, 56–64
(January 2009); doi:10.1038/ncb1812
| Summary | Full Text (HTML / PDF) |

news and views
Membrane repair redux: redox of MG53
Paul McNeil
Nature Cell Biology 11, 7–9
(January 2009); doi:10.1038/ncb0109-7
| Full Text (HTML / PDF) |

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An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
Marco A. Calzado, Laureano de la Vega, Andreas Möller, David D. L. Bowtell & M. Lienhard Schmitz
Nature Cell Biology 11, 85–91
(January 2009); doi:10.1038/ncb1816
| Summary | Full Text (HTML / PDF) |

review
Mechanotransduction in vascular physiology and atherogenesis
Cornelia Hahn & Martin A. Schwartz
Nature Reviews Molecular Cell Biology 10, 53–62
(January 2009); doi:10.1038/nrm2596
| Summary | Full Text (HTML / PDF) |

review
The 3Ms of central spindle assembly: microtubules, motors and MAPs
Michael Glotzer
Nature Reviews Molecular Cell Biology 10, 9–20
(January 2009); doi:10.1038/nrm2609
| Summary | Full Text (HTML / PDF) |

article
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Xin Yu et al.
Nature Immunology 10, 48–57
(January 2009); doi:10.1038/ni.1674
| Summary | Full Text (HTML / PDF) |

article
The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity
Monika Pruenster et al.
Nature Immunology 10, 101–108
(January 2009); doi:10.1038/ni.1675
| Summary | Full Text (HTML / PDF) |

review
Scaffold proteins and immune-cell signalling
Andrey S. Shaw & Erin L. Filbert
Nature Reviews Immunology 9, 47–56
(January 2009); doi:10.1038/nri2473
| Summary | Full Text (HTML / PDF) |

article
Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production
Krisztián Németh et al.
Nature Medicine 15, 42–49
(January 2009); doi:10.1038/nm.1905
| Summary | Full Text (HTML / PDF) |

news and views
Mesenchymal stem cells combat sepsis
Alan Tyndall & Vito Pistoia
Nature Medicine 15, 18–20
(January 2009); doi:10.1038/nm0109-18
| Full Text (HTML / PDF) |

perspective
Toll-like receptors and cancer
Seth Rakoff-Nahoum & Ruslan Medzhitov
Nature Reviews Cancer 9, 57–63
(January 2009); doi:10.1038/nrc2541
| Summary | Full Text (HTML / PDF) |

review
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Michael Haberland, Rusty L. Montgomery & Eric N. Olson
Nature Reviews Genetics 10, 32–42
(January 2009); doi:10.1038/nrg2485
| Summary | Full Text (HTML / PDF) |

article
Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa
Claudio Punzo, Karl Kornacker & Constance L Cepko
Nature Neuroscience 12, 44–52
(January 2009); doi:10.1038/nn.2234
| Summary | Full Text (HTML / PDF) |

news and views
Retinitis pigmentosa: cone photoreceptors starving to death
Paola Bovolenta & Elsa Cisneros
Nature Neuroscience 12, 5–6
(January 2009); doi:10.1038/nn0109-5
| Full Text (HTML / PDF) |

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Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
Adlen Foudi et al.
Nature Biotechnology 27, 84–90
(January 2009); doi:10.1038/nbt.1517
| Summary | Full Text (HTML / PDF) |

review
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
P. Jeffrey Conn, Arthur Christopoulos & Craig W. Lindsley
Nature Reviews Drug Discovery 8, 41–54
(January 2009); doi:10.1038/nrd2760
| Summary | Full Text (HTML / PDF) |

article
Histone H3 tail clipping regulates gene expression
Helena Santos-Rosa et al.
Nature Structural & Molecular Biology 16, 17–22
(January 2009); doi:10.1038/nsmb.1534
| Summary | Full Text (HTML / PDF) |

brief communication
An in vitro microfluidic approach to generating protein-interaction networks
Doron Gerber, Sebastian J Maerkl & Stephen R Quake
Nature Methods 6, 71–74
(January 2009); doi:10.1038/nmeth.1289
| Summary | Full Text (HTML / PDF) |

perspective
Literature-curated protein interaction datasets
Michael E Cusick et al.
Nature Methods 6, 39–46
(January 2009); doi:10.1038/nmeth.1284
| Summary | Full Text (HTML / PDF) |

brief communication
Peptidase substrates via global peptide profiling
Debarati M Tagore et al.
Nature Chemical Biology 5, 23–25
(January 2009); doi:10.1038/nchembio.126
| Summary | Full Text (HTML / PDF) |

news and views
Metabolomics cuts to the chase to chase the cuts
Matthew Bogyo
Nature Chemical Biology 5, 5–6
(January 2009); doi:10.1038/nchembio0109-5
| Full Text (HTML / PDF) |

article
TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch
Irwin M Liu et al.
The EMBO Journal 28, 88–98
(January 2009); doi:10.1038/emboj.2008.266
| Summary | Full Text (HTML / PDF) |

article
The nature of the globular- to fibrous-actin transition
Toshiro Oda, Mitsusada Iwasa, Tomoki Aihara, Yuichiro Maéda & Akihiro Narita
Nature 457, 441–445
(22 January 2009); doi:10.1038/nature07685
| Summary | Full Text (HTML / PDF) |

news and views
Structural biology: Actin in a twist
Kenneth C. Holmes
Nature 457, 389–390
(22 January 2009); doi:10.1038/457389a
| Full Text (HTML / PDF) |

article
Intersubunit coordination in a homomeric ring ATPase
Jeffrey R. Moffitt, Yann R. Chemla, K. Aathavan, Shelley Grimes, Paul J. Jardine, Dwight L. Anderson & Carlos Bustamante
Nature 457, 446–450
(22 January 2009); doi:10.1038/nature07637
| Summary | Full Text (HTML / PDF) |

news and views
Molecular biology: Concealed enzyme coordination
Elio A. Abbondanzieri & Xiaowei Zhuang
Nature 457, 392–393
(22 January 2009); doi:10.1038/457392a
| Full Text (HTML / PDF) |

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Protein kinase R reveals an evolutionary model for defeating viral mimicry
Nels C. Elde, Stephanie J. Child, Adam P. Geballe & Harmit S. Malik
Nature 457, 485–489
(22 January 2009); doi:10.1038/nature07529
| Summary | Full Text (HTML / PDF) |

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Pulsed contractions of an actin–myosin network drive apical constriction
Adam C. Martin, Matthias Kaschube & Eric F. Wieschaus
Nature 457, 495–499
(22 January 2009); doi:10.1038/nature07522
| Summary | Full Text (HTML / PDF) |

review
On the road to reading the RNA-interference code
Haruhiko Siomi & Mikiko C. Siomi
Nature 457, 396–404
(22 January 2009); doi:10.1038/nature07754
| Summary | Full Text (HTML / PDF) |

review
A three-dimensional view of the molecular machinery of RNA interference
Martin Jinek & Jennifer A. Doudna
Nature 457, 405–412
(22 January 2009); doi:10.1038/nature07755
| Summary | Full Text (HTML / PDF) |

review
Small RNAs in transcriptional gene silencing and genome defence
Danesh Moazed
Nature 457, 413–420
(22 January 2009); doi:10.1038/nature07756
| Summary | Full Text (HTML / PDF) |

review
Viral and cellular messenger RNA targets of viral microRNAs
Bryan R. Cullen
Nature 457, 421–425
(22 January 2009); doi:10.1038/nature07757
| Summary | Full Text (HTML / PDF) |

review
The promises and pitfalls of RNA-interference-based therapeutics
Daniela Castanotto & John J. Rossi
Nature 457, 426–433
(22 January 2009); doi:10.1038/nature07758
| Summary | Full Text (HTML / PDF) |

article
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
Koichi Kobayashi, Min Luo, Yue Zhang et al.
Nature Cell Biology 11, 46–55
(January 2009); doi:10.1038/ncb1811
| Summary | Full Text (HTML / PDF) |

news and views
sFRPs: a declaration of (Wnt) independence
Elisha Nathan & Eldad Tzahor
Nature Cell Biology 11, 13
(January 2009); doi:10.1038/ncb0109-13
| Full Text (HTML / PDF) |

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Regulation of cytokinesis by Rho GTPase flux
Ann L. Miller & William M. Bement
Nature Cell Biology 11, 71–77
(January 2009); doi:10.1038/ncb1814
| Summary | Full Text (HTML / PDF) |

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Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance
Tae Ho Lee et al.
Nature Cell Biology 11, 97–105
(January 2009); doi:10.1038/ncb1818
| Summary | Full Text (HTML / PDF) |

review
Neurosensory mechanotransduction
Martin Chalfie
Nature Reviews Molecular Cell Biology 10, 44–52
(January 2009); doi:10.1038/nrm2595
| Summary | Full Text (HTML / PDF) |

review
Mechanotransduction gone awry
Diana E. Jaalouk & Jan Lammerding
Nature Reviews Molecular Cell Biology 10, 63–73
(January 2009); doi:10.1038/nrm2597
| Summary | Full Text (HTML / PDF) |

article
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D Blackburn et al.
Nature Immunology 10, 29–37
(January 2009); doi:10.1038/ni.1679
| Summary | Full Text (HTML / PDF) |

article
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor–induced proliferation
Srividya Sriskantharajah et al.
Nature Immunology 10, 38–47
(January 2009); doi:10.1038/ni.1685
| Summary | Full Text (HTML / PDF) |

perspective
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
Mauro Perretti & Fulvio D'Acquisto
Nature Reviews Immunology 9, 62–70
(January 2009); doi:10.1038/nri2470
| Summary | Full Text (HTML / PDF) |

article
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Ulrike Stein et al.
Nature Medicine 15, 59–67
(January 2009); doi:10.1038/nm.1889
| Summary | Full Text (HTML / PDF) |

review
Tetraspanins: push and pull in suppressing and promoting metastasis
Margot Zöller
Nature Reviews Cancer 9, 40–55
(January 2009); doi:10.1038/nrc2543
| Summary | Full Text (HTML / PDF) |

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Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs
Joseph M Ziegelbauer, Christopher S Sullivan & Don Ganem
Nature Genetics 41, 130–134
(January 2009); doi:10.1038/ng.266
| Summary | Full Text (HTML / PDF) |

news and views
Searching for targets of viral microRNAs
Denise Whitby
Nature Genetics 41, 7–8
(January 2009); doi:10.1038/ng0109-7
| Full Text (HTML / PDF) |

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Characterization of human embryonic stem cells with features of neoplastic progression
Tamra E Werbowetski-Ogilvie et al.
Nature Biotechnology 27, 91–97
(January 2009); doi:10.1038/nbt.1516
| Summary | Full Text (HTML / PDF) |

perspective
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
Véronique Baud & Michael Karin
Nature Reviews Drug Discovery 8, 33–40
(January 2009); doi:10.1038/nrd2781
| Summary | Full Text (HTML / PDF) |

article
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
Stefan Rothenburg, Eun Joo Seo, James S Gibbs, Thomas E Dever & Katharina Dittmar
Nature Structural & Molecular Biology 16, 63–70
(January 2009); doi:10.1038/nsmb.1529
| Summary | Full Text (HTML / PDF) |

article
The mechanism of pentabromopseudilin inhibition of myosin motor activity
Roman Fedorov et al.
Nature Structural & Molecular Biology 16, 80–88
(January 2009); doi:10.1038/nsmb.1542
| Summary | Full Text (HTML / PDF) |

article
High-resolution mapping of copy-number alterations with massively parallel sequencing
Derek Y Chiang et al.
Nature Methods 6, 99–103
(January 2009); doi:10.1038/nmeth.1276
| Summary | Full Text (HTML / PDF) |

brief communication
Stable knockdown of microRNA in vivo by lentiviral vectors
Bernhard Gentner et al.
Nature Methods 6, 63–66
(January 2009); doi:10.1038/nmeth.1277
| Summary | Full Text (HTML / PDF) |

article
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z Long et al.
Nature Chemical Biology 5, 37–44
(January 2009); doi:10.1038/nchembio.129
| Summary | Full Text (HTML / PDF) |

news and views
Decoding endocannabinoid signaling
Lawrence J Marnett
Nature Chemical Biology 5, 8–9
(January 2009); doi:10.1038/nchembio0109-8
| Full Text (HTML / PDF) |

article
Induced pluripotent stem cells from a spinal muscular atrophy patient
Allison D. Ebert et al.
Nature 457, 277–280
(15 January 2009); doi:10.1038/nature07677
| Summary | Full Text (HTML / PDF) |

news and views
Stem cells: Tailor-made diseased neurons
Michael Sendtner
Nature 457, 269–270
(15 January 2009); doi:10.1038/457269a
| Full Text (HTML / PDF) |

article
Photon capture and signalling by melanopsin retinal ganglion cells
Michael Tri H. Do et al.
Nature 457, 281–287
(15 January 2009); doi:10.1038/nature07682
| Summary | Full Text (HTML / PDF) |

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A tunable synthetic mammalian oscillator
Marcel Tigges, Tatiana T. Marquez-Lago, Jörg Stelling & Martin Fussenegger
Nature 457, 309–312
(15 January 2009); doi:10.1038/nature07616
| Summary | Full Text (HTML / PDF) |

news and views
Synthetic biology: The yin and yang of nature
Jeff Gore & Alexander van Oudenaarden
Nature 457, 271–272
(15 January 2009); doi:10.1038/457271a
| Full Text (HTML / PDF) |

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Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids
Zhongfu Ni et al.
Nature 457, 327–331
(15 January 2009); doi:10.1038/nature07523
| Summary | Full Text (HTML / PDF) |

article
Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility
Aaron J. Tooley et al.
Nature Cell Biology 11, 17–26
(January 2009); doi:10.1038/ncb1808
| Summary | Full Text (HTML / PDF) |

news and views
Undressing a cellular corset: septins exposed
Melissa C. Srougi & Keith Burridge
Nature Cell Biology 11, 9–10
(January 2009); doi:10.1038/ncb0109-9
| Full Text (HTML / PDF) |

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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage
Yong-Chul Kim et al.
Nature Cell Biology 11, 92–96
(January 2009); doi:10.1038/ncb1817
| Summary | Full Text (HTML / PDF) |

review
Mechanotransduction in development: a growing role for contractility
Michele A. Wozniak & Christopher S. Chen
Nature Reviews Molecular Cell Biology 10, 34–43
(January 2009); doi:10.1038/nrm2592
| Summary | Full Text (HTML / PDF) |

perspective
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Ning Wang, Jessica D. Tytell & Donald E. Ingber
Nature Reviews Molecular Cell Biology 10, 75–82
(January 2009); doi:10.1038/nrm2594
| Summary | Full Text (HTML / PDF) |

article
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
Jochen C Hartner, Carl R Walkley, Jun Lu & Stuart H Orkin
Nature Immunology 10, 109–115
(January 2009); doi:10.1038/ni.1680
| Summary | Full Text (HTML / PDF) |

news and views
A new function for the RNA-editing enzyme ADAR1
Hisashi Iizasa & Kazuko Nishikura
Nature Immunology 10, 16–18
(January 2009); doi:10.1038/ni0109-16
| Full Text (HTML / PDF) |

review
Calcium signaling in immune cells
Monika Vig & Jean-Pierre Kinet
Nature Immunology 10, 21–27
(January 2009); doi:10.1038/ni.f.220
| Summary | Full Text (HTML / PDF) |

article
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J Real et al.
Nature Medicine 15, 50–58
(January 2009); doi:10.1038/nm.1900
| Summary | Full Text (HTML / PDF) |

news and views
γ-secretase inhibitors: Notch so bad
Gerard C Grosveld
Nature Medicine 15, 20–21
(January 2009); doi:10.1038/nm0109-20
| Full Text (HTML / PDF) |

article
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy
Kristina Lorenz, Joachim P Schmitt, Eva M Schmitteckert & Martin J Lohse
Nature Medicine 15, 75–83
(January 2009); doi:10.1038/nm.1893
| Summary | Full Text (HTML / PDF) |

review
The biology of Hodgkin's lymphoma
Ralf Küppers
Nature Reviews Cancer 9, 15–27
(January 2009); doi:10.1038/nrc2542
| Summary | Full Text (HTML / PDF) |

letter
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
Nisha Limaye et al.
Nature Genetics 41, 118–124
(January 2009); doi:10.1038/ng.272
| Summary | Full Text (HTML / PDF) |

review
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Alexandra Zhernakova, Cleo C. van Diemen & Cisca Wijmenga
Nature Reviews Genetics 10, 43–55
(January 2009); doi:10.1038/nrg2489
| Summary | Full Text (HTML / PDF) |

review
Bidirectional modulation of synaptic functions by Eph/ephrin signaling
Rüdiger Klein
Nature Neuroscience 12, 15–20
(January 2009); doi:10.1038/nn.2231
| Summary | Full Text (HTML / PDF) |

letter
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
Jinyan Du et al.
Nature Biotechnology 27, 77–83
(January 2009); doi:10.1038/nbt.1513
| Summary | Full Text (HTML / PDF) |

perspective
Chemokine receptor antagonists: overcoming developmental hurdles
Richard Horuk
Nature Reviews Drug Discovery 8, 23–33
(January 2009); doi:10.1038/nrd2734
| Summary | Full Text (HTML / PDF) |

article
miR-29 miRNAs activate p53 by targeting p85α and CDC42
Seong-Yeon Park, Jung Hyun Lee, Minju Ha, Jin-Wu Nam & V Narry Kim
Nature Structural & Molecular Biology 16, 23–29
(January 2009); doi:10.1038/nsmb.1533
| Summary | Full Text (HTML / PDF) |

brief communication
Integrated network analysis platform for protein-protein interactions
Jianmin Wu et al.
Nature Methods 6, 75–77
(January 2009); doi:10.1038/nmeth.1282
| Summary | Full Text (HTML / PDF) |

article
Substrate selection by the proteasome during degradation of protein complexes
Sumit Prakash, Tomonao Inobe, Ace Joseph Hatch & Andreas Matouschek
Nature Chemical Biology 5, 29–36
(January 2009); doi:10.1038/nchembio.130
| Summary | Full Text (HTML / PDF) |

news and views
The proteasome makes sense of mixed signals
Thomas J Wandless
Nature Chemical Biology 5, 3–4
(January 2009); doi:10.1038/nchembio0109-3
| Full Text (HTML / PDF) |

article
PTEN regulation by Akt–EGR1–ARF–PTEN axis
Jianxiu Yu et al.
The EMBO Journal 28, 21–33
(January 2009); doi:10.1038/emboj.2008.238
| Summary | Full Text (HTML / PDF) |

article
Cancer induction by restriction of oncogene expression to the stem cell compartment
María Pérez-Caro et al.
The EMBO Journal 28, 8–20
(January 2009); doi:10.1038/emboj.2008.253
| Summary | Full Text (HTML / PDF) |

letter
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
Jiyun V. Kim, Silvia S. Kang, Michael L. Dustin & Dorian B. McGavern
Nature 457, 191–195
(08 January 2009); doi:10.1038/nature07591
| Summary | Full Text (HTML / PDF) |

letter
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
Nature 457, 200–204
(08 January 2009); doi:10.1038/nature07475
| Summary | Full Text (HTML / PDF) |

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Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
Patrick Narbonne & Richard Roy
Nature 457, 210–214
(08 January 2009); doi:10.1038/nature07536
| Summary | Full Text (HTML / PDF) |

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Analysis of combinatorial cis-regulation in synthetic and genomic promoters
Jason Gertz, Eric D. Siggia & Barak A. Cohen
Nature 457, 215–218
(08 January 2009); doi:10.1038/nature07521
| Summary | Full Text (HTML / PDF) |

letter
Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Debashis Ghosh, Jennifer Griswold, Mary Erman & Walter Pangborn
Nature 457, 219–223
(08 January 2009); doi:10.1038/nature07614
| Summary | Full Text (HTML / PDF) |

news and views
Structural biology: Anticancer drug target pictured
Michael R. Waterman
Nature 457, 159–160
(08 January 2009); doi:10.1038/457159a
| Full Text (HTML / PDF) |

article
Apoptotic histone modification inhibits nuclear transport by regulating RCC1
Chi-Hang Wong et al.
Nature Cell Biology 11, 36–45
(January 2009); doi:10.1038/ncb1810
| Summary | Full Text (HTML / PDF) |

news and views
Ran out of the nucleus for apoptosis
Andrew Wilde & Yixian Zheng
Nature Cell Biology 11, 11–12
(January 2009); doi:10.1038/ncb0109-11
| Full Text (HTML / PDF) |

brief communication
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning
Hiroshi Hanafusa, Kunihiro Matsumoto & Eisuke Nishida
Nature Cell Biology 11, 106–109
(January 2009); doi:10.1038/ncb1820
| Summary | Full Text (HTML / PDF) |

review
Environmental sensing through focal adhesions
Benjamin Geiger, Joachim P. Spatz & Alexander D. Bershadsky
Nature Reviews Molecular Cell Biology 10, 21–33
(January 2009); doi:10.1038/nrm2593
| Summary | Full Text (HTML / PDF) |

article
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
Tom Cupedo et al.
Nature Immunology 10, 66–74
(January 2009); doi:10.1038/ni.1668
| Summary | Full Text (HTML / PDF) |

article
Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
Carmelo Luci et al.
Nature Immunology 10, 75–82
(January 2009); doi:10.1038/ni.1681
| Summary | Full Text (HTML / PDF) |

article
RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
Stephanie L Sanos et al.
Nature Immunology 10, 83–91
(January 2009); doi:10.1038/ni.1684
| Summary | Full Text (HTML / PDF) |

news and views
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Karl-Johan Malmberg & Hans-Gustaf Ljunggren
Nature Immunology 10, 11–12
(January 2009); doi:10.1038/ni0109-11
| Full Text (HTML / PDF) |

review
SLAM receptors and SAP influence lymphocyte interactions, development and function
Pamela L. Schwartzberg, Kristen L. Mueller, Hai Qi & Jennifer L. Cannons
Nature Reviews Immunology 9, 39–46
(January 2009); doi:10.1038/nri2456
| Summary | Full Text (HTML / PDF) |

review
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang, Priscilla L. Yang & Nathanael S. Gray
Nature Reviews Cancer 9, 28–39
(January 2009); doi:10.1038/nrc2559
| Summary | Full Text (HTML / PDF) |

review
Transient receptor potential channels: targeting pain at the source
Ardem Patapoutian, Simon Tate & Clifford J. Woolf
Nature Reviews Drug Discovery 8, 55–68
(January 2009); doi:10.1038/nrd2757
| Summary | Full Text (HTML / PDF) |

article
An empirical framework for binary interactome mapping
Kavitha Venkatesan et al.
Nature Methods 6, 83–90
(January 2009); doi:10.1038/nmeth.1280
| Summary | Full Text (HTML / PDF) |

article
An experimentally derived confidence score for binary protein-protein interactions
Pascal Braun et al.
Nature Methods 6, 91–97
(January 2009); doi:10.1038/nmeth.1281
| Summary | Full Text (HTML / PDF) |

resource
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network
Nicolas Simonis et al.
Nature Methods 6, 47–54
(January 2009); doi:10.1038/nmeth.1279
| Summary | Full Text (HTML / PDF) |

article
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor
Griet Van Zeebroeck, Beatriz Monge Bonini, Matthias Versele & Johan M Thevelein
Nature Chemical Biology 5, 45–52
(January 2009); doi:10.1038/nchembio.132
| Summary | Full Text (HTML / PDF) |

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