Research library: G-protein/GPCR signaling
2003: December
| November | October
| September | August
| July | June
| May | April
| March | February
| January
Other Years: 2002 | 2004 | 2005 | 2006 | 2007 | 2008
January
article
Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1
Mousheng Wu, Lei Lu, Wanjin Hong and Haiwei Song
Nature Structural and Molecular Biology 11, 86–94
(January 2004); doi:10.1038/nsmb714
| Abstract | Full Text (HTML/PDF) |
letters to nature
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Mehrdad Matloubian, Charles G. Lo, Guy Cinamon, Matthew J. Lesneski, Ying Xu, Volker Brinkmann, Maria L. Allende, Richard L. Proia and Jason G. Cyster
Nature 427, 355–360
(22 January 2004); doi:10.1038/nature02284
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
Sharon A. Matheny, Chiyuan Chen, Robert L. Kortum, Gina L. Razidlo, Robert E. Lewis and Michael A. White
Nature 427, 256–260
(15 January 2004); doi:10.1038/nature02237
| First Paragraph | Full Text (HTML / PDF) |
review article
Tubby proteins: the plot thickens
Kilpatrick Carroll, Carlos Gomez and Lawrence Shapiro
Nature Reviews Molecular Cell Biology 5, 55–64
(January 2004); doi:10.1038/nrm1278
| Abstract | Full Text (HTML / PDF) |
letters to nature
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation
Koji M. Nishiguchi, Michael A. Sandberg, Aart C. Kooijman, Kirill A. Martemyanov, Jan W. R. Pott, Stephanie A. Hagstrom, Vadim Y. Arshavsky, Eliot L. Berson and Thaddeus P. Dryja
Nature 427, 75–78
(01 January 2004); doi:10.1038/nature02170
| First Paragraph | Full Text (HTML / PDF) |
news and views
Vision: The need for speed
Kendall J. Blumer
Nature 427, 20–21
(01 January 2004); doi:10.1038/427020a
| Full Text (HTML / PDF) |
December
letter
Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation
Paola Camera, Jorge Santos Da Silva, Gareth Griffiths, Maria Gabriella Giuffrida, Luciana Ferrara, Vanessa Schubert, Sara Imarisio, Lorenzo Silengo, Carlos G. Dotti and Ferdinando Di Cunto
Nature Cell Biology 5, 1071–1078
(December 2003); doi:10.1038/ncb1064
| First Paragraph | Full Text (HTML/PDF) |
letter
RGS16 inhibits signalling through the Gα13-Rho axis
Eric N. Johnson, Tammy M. Seasholtz, Abdul A. Waheed, Barry Kreutz, Nobuchika Suzuki, Tohru Kozasa, Teresa L.Z. Jones, Joan Heller Brown and Kirk M. Druey
Nature Cell Biology 5, 1095–1103
(December 2003); doi:10.1038/ncb1065
| First Paragraph | Full Text (HTML/PDF) |
article
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
Mary Tang, Guang Wang, Ping Lu, Richard H Karas, Mark Aronovitz, Scott P Heximer, Kevin M Kaltenbronn, Kendall J Blumer, David P Siderovski, Yan Zhu and Michael E Mendelsohn
Nature Medicine 9, 1506–1512
(December 2003); doi:10.1038/nm958
| Abstract | Full Text (HTML/PDF) |
news and views
Push me, pull you
Charlotte Schubert
Nature Medicine 9, 1466
(December 2003); doi:10.1038/nm1203-1466
| Full Text (HTML/PDF) |
letter
Scaffold-mediated symmetry breaking by Cdc42p
Javier E. Irazoqui, Amy S. Gladfelter and Daniel J. Lew
Nature Cell Biology 5, 1062–1070
(December 2003); doi:10.1038/ncb1068
| First Paragraph | Full Text (HTML/PDF) |
news and views
Go ahead, break my symmetry!
Kendall J. Blumer and John A. Cooper
Nature Cell Biology 5, 1048–1049
(December 2003); doi:10.1038/ncb1203-1048
| Full Text (HTML/PDF) |
article
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
Marcy A Kingsbury, Stevens K Rehen, James J A Contos, Christine M Higgins and Jerold Chun
Nature Neuroscience 6, 1292–1299
(December 2003); doi:10.1038/nn1157
| Abstract | Full Text (HTML/PDF) |
review article
Signalling mechanisms mediating neuronal responses to guidance cues
Kun-Liang Guan and Yi Rao
Nature Reviews Neuroscience 4, 941–956
(December 2003); doi:10.1038/nrn1254
| Abstract | Full Text (HTML / PDF) |
review article
Proteinase-activated receptors in the nervous system
Farshid Noorbakhsh , Nathalie Vergnolle , Morley D. Hollenberg and Christopher Power
Nature Reviews Neuroscience 4, 981–990
(December 2003); doi:10.1038/nrn1255
| Abstract | Full Text (HTML / PDF) |
review article
Opportunities in somatostatin research: biological, chemical and therapeutic aspects
Gisbert Weckbecker, Ian Lewis, Rainer Albert, Herbert A. Schmid, Daniel Hoyer and Christian Bruns
Nature Reviews Drug Discovery 2, 999–1017
(December 2003); doi:10.1038/nrd1255
| Abstract | Full Text (HTML / PDF) |
article
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
Louis Renault, Bernard Guibert and Jacqueline Cherfils
Nature 426, 525–530
(04 December 2003); doi:10.1038/nature02197
| Abstract | Full Text (HTML / PDF) |
letters to nature
Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature
Joëlle Bigay, Pierre Gounon, Sylviane Robineau and Bruno Antonny
Nature 426, 563–566
(04 December 2003); doi:10.1038/nature02108
| First Paragraph | Full Text (HTML / PDF) |
news and views
Membrane trafficking: Coat control by curvature
Jennifer Lippincott-Schwartz and Wei Liu
Nature 426, 507–508
(04 December 2003); doi:10.1038/426507a
| Full Text (HTML / PDF) |
letters to nature
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
Kristina Lorenz, Martin J. Lohse and Ursula Quitterer
Nature 426, 574–579
(04 December 2003); doi:10.1038/nature02158
| First Paragraph | Full Text (HTML / PDF) |
letter
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
Mark T. Uhlik, Amy N. Abell, Nancy L. Johnson, Weiyong Sun, Bruce D. Cuevas, Katherine E. Lobel-Rice, Eric A. Horne, Mark L. Dell'Acqua and Gary L. Johnson
Nature Cell Biology 5, 1104–1110
(December 2003); doi:10.1038/ncb1071
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
Saïd M. Sebti and Channing J. Der
Nature Reviews Cancer 3, 945–951
(December 2003); doi:10.1038/nrc1234
| Abstract | Full Text (HTML / PDF) |
news and views
Folding the cortex
Annette Markus
Nature Neuroscience 6, 1249
(December 2003); doi:10.1038/nn1203-1249
| Full Text (HTML/PDF) |
review article
The developmental role of serotonin: news from mouse molecular genetics
Patricia Gaspar, Olivier Cases and Luc Maroteaux
Nature Reviews Neuroscience 4, 1002–1012
(December 2003); doi:10.1038/nrn1256
| Abstract | Full Text (HTML / PDF) |
November
letter
G13 is an essential mediator of platelet activation in hemostasis and thrombosis
Alexandra Moers, Bernhard Nieswandt, Steffen Massberg, Nina Wettschureck, Sabine Grüner, Ildiko Konrad, Valerie Schulte, Barsom Aktas, Marie-Pierre Gratacap, Melvin I Simon, Meinrad Gawaz and Stefan Offermanns
Nature Medicine 9, 1418–1422
(November 2003); doi:10.1038/nm943
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1
Sang Jeong Kim, Yu Shin Kim, Joseph P. Yuan, Ronald S. Petralia, Paul F. Worley and David J. Linden
Nature 426, 285–291
(20 November 2003); doi:10.1038/nature02162
| First Paragraph | Full Text (HTML / PDF) |
article
Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1
Candida Rogers, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris Li, Peter Evans and Mario de Bono
Nature Neuroscience 6, 1178–1185
(November 2003); doi:10.1038/nn1140
| Abstract | Full Text (HTML/PDF) |
news and views
Food for thought: a receptor finds its ligand
Christopher J. Potter and Liqun Luo
Nature Neuroscience 6, 1119–1120
(November 2003); doi:10.1038/nn1103-1119
| Full Text (HTML/PDF) |
news and views
The kinetochore NUPtials
P. Todd Stukenberg and Ian G. Macara
Nature Cell Biology 5, 945–947
(November 2003); doi:10.1038/ncb1103-945
| Full Text (HTML/PDF) |
article
A genetic approach to inactivating chemokine receptors using a modified viral protein
V McNeil Coffield, Qi Jiang & Lishan Su
Nature Biotechnology 21,1321–1327
( 2000); doi:10.1038/nbt889
| Full Text (HTML/PDF) |
news and views
Three Yips for Rab recruitment
Jemima Barrowman and Peter Novick
Nature Cell Biology 5, 955–956
(November 2003); doi:10.1038/ncb1103-955
| Full Text (HTML/PDF) |
October
letter
Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
Vincent H Gattone II, Xiaofang Wang, Peter C Harris and Vicente E Torres
Nature Medicine 9, 1323–1326
(October 2003); doi:10.1038/nm935
| First Paragraph | Full Text (HTML/PDF) |
review article
Cannabinoids: potential anticancer agents
Manuel Guzmán
Nature Reviews Cancer 3, 745–755
(October 2003); doi:10.1038/nrc1188
| Abstract | Full Text (HTML / PDF) |
article
Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids
Solange P Brown, Stephan D Brenowitz and Wade G Regehr
Nature Neuroscience 6, 1048–1057
(October 2003); doi:10.1038/nn1126
| Abstract | Full Text (HTML/PDF) |
letters to nature
Yip3 catalyses the dissociation of endosomal Rab-GDI complexes
Ulf Sivars, Dikran Aivazian and Suzanne R. Pfeffer
Nature 425, 856–859
(23 October 2003); doi:10.1038/nature02057
| First Paragraph | Full Text (HTML / PDF) |
letter
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
Laurent Ruel, Ralph Rodriguez, Armel Gallet, Laurence Lavenant-Staccini and Pascal P. Thérond
Nature Cell Biology 5, 907–913
(October 2003); doi:10.1038/ncb1052
| Abstract | Full Text (HTML/PDF) |
article
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
Katayoon Goodarzi, Mahmoud Goodarzi, Andrew M Tager, Andrew D Luster and Ulrich H von Andrian
Nature Immunology 4, 965–973
(October 2003); doi:10.1038/ni972
| Abstract | Full Text (HTML/PDF) |
article
Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4
Vanessa L Ott, John C Cambier, John Kappler, Philippa Marrack & Bradley J Swanson
Nature Immunology 4,974–981
( 2000); doi:10.1038/ni971
| Abstract
| Full Text (HTML/PDF) |
article
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
Andrew M Tager, Shannon K Bromley, Benjamin D Medoff, Sabina A Islam, Scott D Bercury, Erik B Friedrich, Andrew D Carafone, Robert E Gerszten and Andrew D Luster
Nature Immunology 4, 982–990
(October 2003); doi:10.1038/ni970
| Abstract | Full Text (HTML/PDF) |
news and views
BLT for speed
Stephen P Schoenberger
Nature Immunology 4, 937–939
(October 2003); doi:10.1038/ni1003-937
| | Full Text (HTML/PDF) |
article
Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis
Michael L Woodruff, Zhongyan Wang, Hae Yun Chung, T Michael Redmond, Gordon L Fain and Janis Lem
Nature Genetics 35, 158–164
(October 2003); doi:10.1038/ng1246
| Abstract | Full Text (HTML/PDF) |
news and views
The dangers of seeing light in the dark
Charlotte E Remé and Andreas Wenzel
Nature Genetics 35, 115–116
(October 2003); doi:10.1038/ng1003-115
| Full Text (HTML/PDF) |
letters to nature
Role of visual pigment properties in rod and cone phototransduction
Vladimir Kefalov, Yingbin Fu, Nicholas Marsh-Armstrong and King-Wai Yau
Nature 425, 526–531
(02 October 2003); doi:10.1038/nature01992
| First Paragraph | Full Text (HTML / PDF) |
review article
Ras GTPases: integrins' friends or foes?
Kayoko Kinbara, Lawrence E. Goldfinger, Malene Hansen, Fan-Li Chou and Mark H. Ginsberg
Nature Reviews Molecular Cell Biology 4, 767–778
(October 2003); doi:10.1038/nrm1229
| Abstract | Full Text (HTML / PDF) |
brief communication
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer
H. Rosie Xing, Carlos Cordon-Cardo, Xinzhu Deng, William Tong, Luis Campodonico, Zvi Fuks and Richard Kolesnick
Nature Medicine 9, 1267–1268
(October 2003); doi:10.1038/nm927
| First Paragraph | Full Text (HTML/PDF) |
September
perspectives
Epac: a new cAMP target and new avenues in cAMP research
Johannes L. Bos
Nature Reviews Molecular Cell Biology 4, 733–738
(September 2003); doi:10.1038/nrm1197
| Abstract | Full Text (HTML / PDF) |
letters to nature
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
Peter Staller, Jitka Sulitkova, Joanna Lisztwan, Holger Moch, Edward J. Oakeley and Wilhelm Krek
Nature 425, 307–311
(18 September 2003); doi:10.1038/nature01874
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Cues for migration
René Bernards
Nature 425, 247–248
(18 September 2003); doi:10.1038/425247a
| Full Text (HTML / PDF) |
letters to nature
Proton-sensing G-protein-coupled receptors
Marie-Gabrielle Ludwig, Miroslava Vanek, Danilo Guerini, Jürg A. Gasser, Carol E. Jones, Uwe Junker, Hans Hofstetter, Romain M. Wolf and Klaus Seuwen
Nature 425, 93–98
(04 September 2003); doi:10.1038/nature01905
| First Paragraph | Full Text (HTML / PDF) |
article
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Matthew J. During, Lei Cao, David S. Zuzga, Jeremy S. Francis, Helen L. Fitzsimons, Xiangyang Jiao, Ross J. Bland, Matthias Klugmann, William A. Banks, Daniel J. Drucker and Colin N. Haile
Nature Medicine 9, 1173–1179
(September 2003); doi:10.1038/nm919
| Abstract | Full Text (HTML/PDF) |
news and views
Learning from the gut
Mark P. Mattson, Tracy Ann Perry and Nigel H. Greig
Nature Medicine 9, 1113–1115
(September 2003); doi:10.1038/nm0903-1113
| Full Text (HTML/PDF) |
August
article
Modulation of glycine-activated ion channel function by G-protein βγ subunits
Gonzalo E. Yevenes, Robert W. Peoples, Juan C. Tapia, Jorge Parodi, Ximena Soto, Juan Olate and Luis G. Aguayo
Nature Neuroscience 6, 819–824
(August 2003); doi:10.1038/nn1095
| Abstract | Full Text (HTML/PDF) |
Scientific Report
RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival
Yuchen Chien & Michael A. White
EMBO reports 4, 800–806
(August 2003); doi:10.1038/sj.embor.embor899
| Full Text (HTML/PDF) |
letter
Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs
Anna Marie Sokac, Carl Co, Jack Taunton and William Bement
Nature Cell Biology 5, 727–732
(August 2003); doi:10.1038/ncb1025
| First Paragraph | Full Text (HTML/PDF) |
news and views
Actin puts on the squeeze
Dorothy A. Schafer
Nature Cell Biology 5, 693–694
(August 2003); doi:10.1038/ncb0803-693
| Full Text (HTML/PDF) |
letter
Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion
Rebecca P. Haberman, R. Jude Samulski and Thomas J. McCown
Nature Medicine 9, 1076–1080
(August 2003); doi:10.1038/nm901
| First Paragraph | Full Text (HTML/PDF) |
news and views
Seizing hold of seizures
Gregory L. Holmes and Yezekiel Ben-Ari
Nature Medicine 9, 994–996
(August 2003); doi:10.1038/nm0803-994
| Full Text (HTML/PDF) |
letters to nature
Direct modulation of synaptic vesicle priming by GABAB receptor activation at a glutamatergic synapse
Takeshi Sakaba and Erwin Neher
Nature 424, 775–778
(14 August 2003); doi:10.1038/nature01859
| First Paragraph | Full Text (HTML / PDF) |
news and views
Getting a GPR on spindle asymmetry
S. Swaminathan
Nature Cell Biology 5, 692
(August 2003); doi:10.1038/ncb0803-692
| Full Text (HTML/PDF) |
article
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
Koko Katagiri, Akito Maeda, Mika Shimonaka and Tatsuo Kinashi
Nature Immunology 4, 741–748
(August 2003); doi:10.1038/ni950
| Abstract | Full Text (HTML/PDF) |
review article
The emerging role of lysophosphatidic acid in cancer
Gordon B. Mills and Wouter H. Moolenaar
Nature Reviews Cancer 3, 582–591
(August 2003); doi:10.1038/nrc1143
| Abstract | Full Text (HTML / PDF) |
letters to nature
Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1
Trever G. Bivona, Ignacio Pérez de Castro, Ian M. Ahearn, Theresa M. Grana, Vi K. Chiu, Peter J. Lockyer, Peter J. Cullen, Angel Pellicer, Adrienne D. Cox and Mark R. Philips
Nature 424, 694–698
(07 August 2003); doi:10.1038/nature01806
| First Paragraph | Full Text (HTML / PDF) |
news and views
Signal transduction: Life on Mars, cellularly speaking
Pier Paolo Di Fiore
Nature 424, 624–625
(07 August 2003); doi:10.1038/424624a
| Full Text (HTML / PDF) |
letters to nature
RanGTP mediates nuclear pore complex assembly
Tobias C. Walther, Peter Askjaer, Marc Gentzel, Anja Habermann, Gareth Griffiths, Matthias Wilm, Iain W. Mattaj and Martin Hetzer
Nature 424, 689–694
(07 August 2003); doi:10.1038/nature01898
| First Paragraph | Full Text (HTML / PDF) |
article
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
Alla Khodorova, Betsy Navarro, Laurence Sophie Jouaville, Jo-Ellen Murphy, Frank L Rice, Joseph E Mazurkiewicz, Denise Long-Woodward, Markus Stoffel, Gary R Strichartz, Rus Yukhananov and Gudarz Davar
Nature Medicine 9, 1055–1061
(August 2003); doi:10.1038/nm885
| Abstract | Full Text (HTML/PDF) |
article
Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation
Fabien M Décaillot, Katia Befort, Dominique Filliol, ShiYi Yue, Philippe Walker and Brigitte L Kieffer
Nature Structural Biology 10, 629–636
(August 2003); doi:10.1038/nsb950
| Abstract | Full Text (HTML/PDF) |
perspectives
Opinion: Transactivation joins multiple tracks to the ERK/MAPK cascade
Reinhard Wetzker and Frank-D. Böhmer
Nature Reviews Molecular Cell Biology 4, 651–657
(August 2003); doi:10.1038/nrm1173
| Abstract | Full Text (HTML / PDF) |
July
letters to nature
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
Hironori Katoh and Manabu Negishi
Nature 424, 461–464
(24 July 2003); doi:10.1038/nature01817
| First Paragraph | Full Text (HTML / PDF) |
letter
Crosstalk between Rap1 and Rac regulates secretion of sAPPα
Marjorie Maillet, Sylvain J. Robert, Mathias Cacquevel, Monique Gastineau, Denis Vivien, Jacques Bertoglio, José L. Zugaza, Rodolphe Fischmeister and Frank Lezoualc'h
Nature Cell Biology 5, 633–639
(July 2003); doi:10.1038/ncb1007
| First Paragraph | Full Text (HTML/PDF) |
research article
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells
Jean-Pierre Vilardaga, Moritz Bünemann, Cornelius Krasel, Marián Castro and Martin J. Lohse
Nature Biotechnology 21, 807–812
(July 2003); doi:10.1038/nbt838
| Abstract | Full Text (HTML/PDF) |
letters to nature
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors
Stephen P. Kelley, James I. Dunlop, Ewen F. Kirkness, Jeremy J. Lambert and John A. Peters
Nature 424, 321–324
(17 July 2003); doi:10.1038/nature01788
| First Paragraph | Full Text (HTML / PDF) |
review article
Extracellular calcium sensing and signalling
Aldebaran M. Hofer and Edward M. Brown
Nature Reviews Molecular Cell Biology 4, 530–538
(July 2003); doi:10.1038/nrm1154
| Summary | Full Text (HTML / PDF) |
review article
Three or more routes for leukocyte migration into the central nervous system
Richard M. Ransohoff, Pia Kivisäkk and Grahame Kidd
Nature Reviews Immunology 3, 569–581
(July 2003); doi:10.1038/nri1130
| Summary | Full Text (HTML / PDF) |
article
Opsin activation as a cause of congenital night blindness
Shengnan Jin, M Carter Cornwall and Daniel D Oprian
Nature Neuroscience 6, 731–735
(July 2003); doi:10.1038/nn1070
| Abstract | Full Text (HTML/PDF) |
letters to nature
T-type calcium channel regulation by specific G-protein βγ subunits
Joshua T. Wolfe, Hongge Wang, Jason Howard, James C. Garrison and Paula Q. Barrett
Nature 424, 209–213
(10 July 2003); doi:10.1038/nature01772
| First Paragraph | Full Text (HTML / PDF) |
article
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Baoji Xu, Evan H Goulding, Keling Zang, David Cepoi, Roger D Cone, Kevin R Jones, Laurence H Tecott and Louis F Reichardt
Nature Neuroscience 6, 736–742
(July 2003); doi:10.1038/nn1073
| Abstract | Full Text (HTML/PDF) |
news and views
The skinny on neurotrophins
Brent E Wisse and Michael W Schwartz
Nature Neuroscience 6, 655–656
(July 2003); doi:10.1038/nn0703-655
| Full Text (HTML/PDF) |
June
perspectives
RAS oncogenes: the first 30 years
Marcos Malumbres and Mariano Barbacid
Nature Reviews Cancer 3, 459–465
(June 2003); doi:10.1038/nrc1097
| Summary | Full Text (HTML / PDF) |
letters to nature
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins
Sylvie Coursol , Liu-Min Fan, Hervé Le Stunff, Sarah Spiegel, Simon Gilroy and Sarah M. Assmann
Nature 423, 651–654
(05 June 2003); doi:10.1038/nature01643
| First Paragraph | Full Text (HTML / PDF) |
review article
Predicting therapeutic value in the lead optimization phase of drug discovery
Terry Kenakin
Nature Reviews Drug Discovery 2, 429–438
(June 2003); doi:10.1038/nrd1110
| Summary | Full Text (HTML / PDF) |
May
letters to nature
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
Kazutoshi Takahashi, Kaoru Mitsui and Shinya Yamanaka
Nature 423, 541–545
(29 May 2003); doi:10.1038/nature01646
| First Paragraph | Full Text (HTML / PDF) |
article
Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium
Kien Trinh and Daniel R. Storm
Nature Neuroscience 6, 519–525
(May 2003); doi:10.1038/nn1039
| Abstract | Full Text (HTML/PDF) |
news and views
Nosing into pheromone detectors
Ivan Rodriguez
Nature Neuroscience 6, 438–440
(May 2003); doi:10.1038/nn0503-438
| Full Text (HTML/PDF) |
review article
Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel and Sheldon Milstien
Nature Reviews Molecular Cell Biology 4, 397–407
(May 2003); doi:10.1038/nrm1103
| Summary | Full Text (HTML / PDF) |
letter
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
Atsuo Sasaki, Takaharu Taketomi, Reiko Kato, Kazuko Saeki, Atsushi Nonami, Mika Sasaki, Masamitsu Kuriyama, Naoaki Saito, Masabumi Shibuya and Akihiko Yoshimura
Nature Cell Biology 5, 427–432
(May 2003); doi:10.1038/ncb978
| First Paragraph | Full Text (HTML/PDF) |
news and views
Split personalities: the agonistic antagonist Sprouty
Gerhard Christofori
Nature Cell Biology 5, 377–379
(May 2003); doi:10.1038/ncb0503-377
| Full Text (HTML/PDF) |
review article
Ras proteins: different signals from different locations
John F. Hancock
Nature Reviews Molecular Cell Biology 4, 373–385
(May 2003); doi:10.1038/nrm1105
| Summary | Full Text (HTML / PDF) |
article
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
Toshihide Yamashita and Masaya Tohyama
Nature Neuroscience 6, 461–467
(May 2003); doi:10.1038/nn1045
| Abstract | Full Text (HTML/PDF) |
news and views
Axon growth inhibition: signals from the p75 neurotrophin receptor
David R. Kaplan and Freda D. Miller
Nature Neuroscience 6, 435–436
(May 2003); doi:10.1038/nn0503-435
| Full Text (HTML/PDF) |
letter
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
Paolo A. Hernandez, Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman and George A. Diaz
Nature Genetics 34, 70–74
(May 2003); doi:10.1038/ng1149
| First Paragraph | Full Text (HTML/PDF) |
April
letter
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
Michael K. Cooper, Christopher A. Wassif, Patrycja A. Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I. Kelley, Forbes D. Porter and Philip A. Beachy
Nature Genetics 33, 508–513
(April 2003); doi:10.1038/ng1134
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
Mayumi Inoue, Louise Chang, Joseph Hwang, Shian-Huey Chiang and Alan R. Saltiel
Nature 422, 629–633
(10 April 2003); doi:10.1038/nature01533
| First Paragraph | Full Text (HTML / PDF) |
March
article
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Sorin Tunaru, Jukka Kero, Annette Schaub, Christian Wufka, Andree Blaukat, Klaus Pfeffer and Stefan Offermanns
Nature Medicine 9, 352–355
(March 2003); doi:10.1038/nm824
| Abstract | Full Text (HTML/PDF) |
letter
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
Akihiro Fujikawa, Daisuke Shirasaka, Shoichi Yamamoto, Hiroyoshi Ota, Kinnosuke Yahiro, Masahide Fukada, Takafumi Shintani, Akihiro Wada, Nobuo Aoyama, Toshiya Hirayama, Hiroshi Fukamachi and Masaharu Noda
Nature Genetics 33, 375–381
(March 2003); doi:10.1038/ng1112
| First Paragraph | Full Text (HTML/PDF) |
news and views
Intoxicated cells and stomach ulcers
Richard M. Peek Jr.
Nature Genetics 33, 328–330
(March 2003); doi:10.1038/ng0303-328
| Full Text (HTML/PDF) |
letter
Redox-dependent downregulation of Rho by Rac
Anjaruwee S. Nimnual, Laura J. Taylor and Dafna Bar-Sagi
Nature Cell Biology 5, 236–241
(March 2003); doi:10.1038/ncb938
| First Paragraph | Full Text (HTML/PDF) |
news and views
Rac signalling: a radical view
Emmanuelle Caron
Nature Cell Biology 5, 185–187
(March 2003); doi:10.1038/ncb0303-185
| Full Text (HTML/PDF) |
brief communication
Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia
Guilherme Lucas, Panu Hendolin, Tibor Harkany, Karin Agerman, Gustavo Paratcha, Carl Holmgren, Yuri Zilberter, Mikko Sairanen, Liliana Minichiello, Eero Castren and Patrik Ernfors
Nature Neuroscience 6, 221–222
(March 2003); doi:10.1038/nn1021
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Yasuaki Itoh, Yuji Kawamata, Masataka Harada, Makoto Kobayashi, Ryo Fujii, Shoji Fukusumi, Kazuhiro Ogi, Masaki Hosoya, Yasuhiro Tanaka, Hiroshi Uejima, Hideyuki Tanaka, Minoru Maruyama, Rie Satoh, Shoichi Okubo, Hideki Kizawa, Hidetoshi Komatsu, Fumika Matsumura, Yuko Noguchi, Tokuyuki Shinohara, Shuji Hinuma, Yukio Fujisawa and Masahiko Fujino
Nature 422, 173–176
(13 March 2003); doi:10.1038/nature01478
| First Paragraph | Full Text (HTML / PDF) |
letter
Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant
Daria E. Siekhaus and David G. Drubin
Nature Cell Biology 5, 231–235
(March 2003); doi:10.1038/ncb941
| First Paragraph | Full Text (HTML/PDF) |
article
The thrombomodulin-protein C system is essential for the maintenance of pregnancy
Berend Isermann, Rashmi Sood, Rafal Pawlinski, Mark Zogg, Shawn Kalloway, Jay L. Degen, Nigel Mackman and Hartmut Weiler
Nature Medicine 9, 331–337
(March 2003); doi:10.1038/nm825
| Abstract | Full Text (HTML/PDF) |
article
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
Tong Cheng, Dong Liu, John H. Griffin, José A. Fernández, Francis Castellino, Elliot D. Rosen, Kenji Fukudome and Berislav V. Zlokovic
Nature Medicine 9, 338–342
(March 2003); doi:10.1038/nm826
| Abstract | Full Text (HTML/PDF) |
news and views
PAR1 signaling: more good than harm?
Wolfram Ruf
Nature Medicine 9, 258–260
(March 2003); doi:10.1038/nm0303-258
| Full Text (HTML/PDF) |
article
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
Jie Fan and Asrar B. Malik
Nature Medicine 9, 315–321
(March 2003); doi:10.1038/nm832
| Abstract | Full Text (HTML/PDF) |
article
RNA interference targeting Fas protects mice from fulminant hepatitis
Erwei Song, Sang-Kyung Lee, Jie Wang, Nedim Ince, Nengtai Ouyang, Jun Min, Jisheng Chen, Premlata Shankar and Judy Lieberman
Nature Medicine 9, 347–351
(March 2003); doi:10.1038/nm828
| Abstract | Full Text (HTML/PDF) |
news and views
siRNAs knock down hepatitis
Phillip D. Zamore and Neil Aronin
Nature Medicine 9, 266–267
(March 2003); doi:10.1038/nm0303-266
| Full Text (HTML/PDF) |
February
review article
The endothelin axis: emerging role in cancer
Joel Nelson, Anna Bagnato, Bruno Battistini and Perry Nisen
Nature Reviews Cancer 3, 110–116
(February 2003); doi:10.1038/nrc990
| Summary | Full Text (HTML / PDF) |
letters to nature
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
Maya Dajee, Mirella Lazarov, Jennifer Y. Zhang, Ti Cai, Cheryl L. Green, Alan J. Russell, M. Peter Marinkovich, Shiying Tao, Qun Lin, Yoshiaki Kubo and Paul A. Khavari
Nature 421, 639–643
(06 February 2003); doi:10.1038/nature01283
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: More than skin deep
Diana Bolotin and Elaine Fuchs
Nature 421, 594–595
(06 February 2003); doi:10.1038/421594a
| Full Text (HTML / PDF) |
review article
The role of histamine and the tuberomamillary nucleus in the nervous system
Helmut Haas and Pertti Panula
Nature Reviews Neuroscience 4, 121–130
(February 2003); doi:10.1038/nrn1034
| Summary | Full Text (HTML / PDF) |
January
article
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
Gürol M. Süel, Steve W. Lockless, Mark A. Wall and Rama Ranganathan
Nature Structural Biology 10, 59–69
(January 2003); doi:10.1038/nsb881
| Abstract | Full Text (HTML/PDF) |
review article
Scientific and therapeutic advances in antiplatelet therapy
Deepak L. Bhatt and Eric J. Topol
Nature Reviews Drug Discovery 2, 15–28
(January 2003); doi:10.1038/nrd985
| Summary | Full Text (HTML / PDF) |
original paper
H-Ras-specific activation of NF-κB protects NIH 3T3 cells against stimulus-dependent apoptosis
Olga Millán, Alicia Ballester, Antonio Castrillo, José Luis de la Oliva, Paqui G Través, José María Rojas and Lisardo Boscá
Oncogene 22, 477–483
(30 January 2003); doi:10.1038/sj.onc.1206179
| Abstract |
letters to nature
A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor
Holger Knaut, Christian Werz, Robert Geisler, The Tübingen 2000 Screen Consortium and Christiane Nüsslein-Volhard
Nature 421, 279–282
(16 January 2003); doi:10.1038/nature01338
| First Paragraph | Full Text (HTML / PDF) |
news and views
Developmental biology: Germ-cell attraction
Prabhat S. Kunwar and Ruth Lehmann
Nature 421, 226–227
(16 January 2003); doi:10.1038/421226a
| Full Text (HTML / PDF) |
news and views
Myelin management
Charlotte Schubert
Nature Medicine 9, 18
(January 2003); doi:10.1038/nm0103-18
| Full Text (HTML/PDF) |
review article
Targeting RAS signalling pathways in cancer therapy
Julian Downward
Nature Reviews Cancer 3, 11–22
(January 2003); doi:10.1038/nrc969
| Summary | Full Text (HTML / PDF) |
brief communication
High frequency of BRAF mutations in nevi
Pamela M. Pollock, Ursula L. Harper, Katherine S. Hansen, Laura M. Yudt, Mitchell Stark, Christiane M. Robbins, Tracy Y. Moses, Galen Hostetter, Urs Wagner, John Kakareka, Ghadi Salem, Tom Pohida, Peter Heenan, Paul Duray, Olli Kallioniemi, Nicholas K. Hayward, Jeffrey M. Trent and Paul S. Meltzer
Nature Genetics 33, 19–20
(January 2003); doi:10.1038/ng1054
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity
Olga Speck, Sarah C. Hughes, Nicole K. Noren, Rima M. Kulikauskas and Richard G. Fehon
Nature 421, 83–87
(02 January 2003); doi:10.1038/nature01295
| First Paragraph | Full Text (HTML / PDF) |
article
Signalling and crosstalk of Rho GTPases in mediating axon guidance
Xiao-bing Yuan, Ming Jin, Xiaohua Xu, Yuan-quan Song, Chien-ping Wu, Mu-ming Poo and Shumin Duan
Nature Cell Biology 5, 38–45
(January 2003); doi:10.1038/ncb895
| Abstract | Full Text (HTML/PDF) |
review article
Metastasis suppressors alter the signal transduction of cancer cells
Patricia S. Steeg
Nature Reviews Cancer 3, 55–63
(January 2003); doi:10.1038/nrc967
| Summary | Full Text (HTML / PDF) |
letter
Nf1 has an essential role in endothelial cells
Aaron D. Gitler, Yuan Zhu, Fraz A. Ismat, Min Min Lu, Yasutaka Yamauchi, Luis F. Parada and Jonathan A. Epstein
Nature Genetics 33, 75–79
(January 2003); doi:10.1038/ng1059
| First Paragraph | Full Text (HTML/PDF) |
news and views
Cre-constructing the heart
Pilar Ruiz-Lozano and Kenneth R. Chien
Nature Genetics 33, 8–9
(January 2003); doi:10.1038/ng0103-8
| Full Text (HTML/PDF) |
article
Structure and regulation of the cAMP-binding domains of Epac2
Holger Rehmann, Balaji Prakash, Eva Wolf, Alma Rueppel, Johan de Rooij,
Johannes L. Bos and Alfred Wittinghofer
Nature Structural Biology 10, 26–32
(January 2003); doi:10.1038/nsb878
| Abstract
| Full Text (HTML/PDF)
|
|
