Research library: G-protein/GPCR signaling
2008:
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July
article
Crystal structure of the ligand-free G-protein-coupled receptor opsin
Jung Hee Park, Patrick Scheerer, Klaus Peter Hofmann, Hui-Woog Choe & Oliver Peter Ernst
Nature 454, 183–187
(10 July 2008); doi:10.1038/nature07063
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review
Ras oncogenes: split personalities
Antoine E. Karnoub & Robert A. Weinberg
Nature Reviews Molecular Cell Biology 9, 517–531
(July 2008); doi:10.1038/nrm2438
| Summary | Full Text (HTML / PDF) |
letter
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos
Chi-Wei Lu, Akiko Yabuuchi, Lingyi Chen, Srinivas Viswanathan, Kitai Kim & George Q Daley
Nature Genetics 40, 921–926
doi:10.1038/ng.173
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perspective
Insights into signaling from the β2-adrenergic receptor structure
Martin Audet & Michel Bouvier
Nature Chemical Biology 4, 397–403
(July 2008); doi:10.1038/nchembio.97
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article
RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation
Yukiko Nakaya, Erike W. Sukowati, Yuping Wu & Guojun Sheng
Nature Cell Biology 10, 765–775
(July 2008); doi:10.1038/ncb1739
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news and views
Breaking down EMT
Romain Levayer & Thomas Lecuit
Nature Cell Biology 10, 757–759
(July 2008); doi:10.1038/ncb0708-757
| Full Text (HTML / PDF) |
scientific report
Crucial structural role for the PH and C1 domains of the Vav1 exchange factor
Jonathan Rapley, Victor L J Tybulewicz & Katrin Rittinger
EMBO reports 9, 655–661
doi:10.1038/embor.2008.80
| Summary | Full Text (HTML / PDF) |
June
review
The septin family of GTPases: architecture and dynamics
Christine S. Weirich, Jan P. Erzberger & Yves Barral
Nature Reviews Molecular Cell Biology 9, 478–489
(June 2008); doi:10.1038/nrm2407
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article
Internal dynamics control activation and activity of the autoinhibited Vav DH domain
Pilong Li, Ilídio R S Martins, Gaya K Amarasinghe & Michael K Rosen
Nature Structural & Molecular Biology 15, 613–618
(June 2008); doi:10.1038/nsmb.1428
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letter
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
Xiaoling Tang et al.
Nature Cell Biology 10, 698–706
(June 2008); doi:10.1038/ncb1732
| Summary | Full Text (HTML / PDF) |
review
Spatial and temporal coordination of mitosis by Ran GTPase
Paul R. Clarke & Chuanmao Zhang
Nature Reviews Molecular Cell Biology 9, 464–477
(June 2008); doi:10.1038/nrm2410
| Summary | Full Text (HTML / PDF) |
article
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel et al.
Nature Methods 5, 561–567
(June 2008); doi:10.1038/nmeth.1213
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article
Activation of the endocannabinoid system by organophosphorus nerve agents
Daniel K Nomura et al.
Nature Chemical Biology 4, 373–378
(June 2008); doi:10.1038/nchembio.86
| Summary | Full Text (HTML / PDF) |
May
letter
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
Yi Guo et al.
Nature 453, 657–661
(29 May 2008); doi:10.1038/nature06928
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article
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure
Stephen B Liggett et al.
Nature Medicine 14, 510–517
(May 2008); doi:10.1038/nm1750
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news and views
β-adrenergic signaling in heart failure—adapt or die
Thomas Eschenhagen
Nature Medicine 14, 485–487
(May 2008); doi:10.1038/nm0508-485
| Summary | Full Text (HTML / PDF) |
letter
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Kevin M Haigis et al.
Nature Genetics 40, 600–608
(May 2008); doi:10.1038/ng.115
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article
Membrane-dependent signal integration by the Ras activator Son of sevenless
Jodi Gureasko et al.
Nature Structural & Molecular Biology 14, 452–461
(May 2008); doi:10.1038/nsmb.1418
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article
Crystal structure of squid rhodopsin
Midori Murakami & Tsutomu Kouyama
Nature 453, 363–367
(15 May 2008); doi:10.1038/nature06925
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news and views
Signal Transduction: The rhodopsin story continued
Gebhard F. X. Schertler
Nature 453, 292–293
(15 May 2008); doi:10.1038/453292a
| Full Text (HTML / PDF) |
letter
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah et al.
Nature 453, 410–414
(15 May 2008); doi:10.1038/nature06868
| Summary | Full Text (HTML / PDF) |
letter
A pathway for phagosome maturation during engulfment of apoptotic cells
Jason M. Kinchen et al.
Nature Cell Biology 10, 556–566
(May 2008); doi:10.1038/ncb1718
| Summary | Full Text (HTML / PDF) |
letter
Imaging of Rab5 activity identifies essential regulators for phagosome maturation
Masahiro Kitano, Michio Nakaya, Takeshi Nakamura, Shigekazu Nagata & Michiyuki Matsuda
Nature 453, 241–245
(8 May 2008); doi:10.1038/nature06857
| Summary | Full Text (HTML / PDF) |
April
article
Lateral presynaptic inhibition mediates gain control in an olfactory circuit
Shawn R. Olsen & Rachel I. Wilson
Nature 452, 956–960
(24 April 2008); doi:10.1038/nature06864
| Summary | Full Text (HTML / PDF) |
letter
Insect olfactory receptors are heteromeric ligand-gated ion channels
Koji Sato et al.
Nature 452, 1002–1006
(24 April 2008); doi:10.1038/nature06850
| Summary | Full Text (HTML / PDF) |
letter
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
Dieter Wicher et al.
Nature 452, 1007–1011
(24 April 2008); doi:10.1038/nature06861
| Summary | Full Text (HTML / PDF) |
news and views
Neuroscience: Current views on odour receptors
Alexander Chesler & Stuart Firestein
Nature 452, 944
(24 April 2008); doi:10.1038/452944a
| Full Text (HTML / PDF) |
letter
elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8
Yoshihiro Omori et al.
Nature Cell Biology 10, 437–444
(April 2008); doi:10.1038/ncb1706
| Summary | Full Text (HTML / PDF) |
review
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerström & Helgi B. Schiöth
Nature Reviews Drug Discovery 7, 339–357
(April 2008); doi:10.1038/nrd2518
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review
How membrane proteins sense voltage
Francisco Bezanilla
Nature Reviews Molecular Cell Biology 9, 323–332
(April 2008); doi:10.1038/nrm2376
| Summary | Full Text (HTML / PDF) |
article
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs
Hidenobu Kanda, Rebecca Newton, Russell Klein, Yuka Morita, Michael D Gunn & Steven D Rosen
Nature Immunology 9, 415–423
(April 2008); doi:10.1038/ni1573
| Summary | Full Text (HTML / PDF) |
news and views
A new player in lymphocyte homing
Dietmar Vestweber & Martin K Wild
Nature Immunology 9, 347–348
(April 2008); doi:10.1038/ni0408-347
| Full Text (HTML / PDF) |
review
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
Jarl E. S. Wikberg & Felikss Mutulis
Nature Reviews Drug Discovery 7, 307–323
(April 2008); doi:10.1038/nrd2331
| Summary | Full Text (HTML / PDF) |
article
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3
Stefan Veltel, Raphael Gasper, Elke Eisenacher & Alfred Wittinghofer
Nature Structural & Molecular Biology 15, 373–380
(April 2008); doi:10.1038/nsmb.1396
| Summary | Full Text (HTML / PDF) |
review
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
Jarl E. S. Wikberg & Felikss Mutulis
Nature Reviews Drug Discovery 7, 307–323
(April 2008); doi:10.1038/nrd2331
| Summary | Full Text (HTML / PDF) |
March
letter
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Sandra M Pasternack et al.
Nature Genetics 40, 329–334
(March 2008); doi:10.1038/ng.84
| Summary | Full Text (HTML / PDF) |
letter
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair
Yutaka Shimomura et al.
Nature Genetics 40, 335–339
(March 2008); doi:10.1038/ng.100
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news and views
Disentangling the roots of inherited hair disorders
Eli Sprecher
Nature Genetics 40, 265–266
(March 2008); doi:10.1038/ng0308-265
| Summary | Full Text (HTML / PDF) |
letter
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2
Peng Ji, Senthil Raja Jayapal & Harvey F. Lodish
Nature Cell Biology 10, 314–321
(March 2008); doi:10.1038/ncb1693
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article
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
Eric Sebzda, Zhiying Zou, John S Lee, Tao Wang & Mark L Kahn
Nature Immunology 9, 292–300
(March 2008); doi:10.1038/ni1565
| Summary | Full Text (HTML / PDF) |
news and views
Innocents abroad: regulating where naive T cells go
Barrett J Rollins
Nature Immunology 9, 233–235
(March 2008); doi:10.1038/ni0308-233
| Full Text (HTML / PDF) |
February
article
Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling
Jean-Pierre Vilardaga, Viacheslav O Nikolaev, Kristina Lorenz, Sébastien Ferrandon, Zhenjie Zhuang & Martin J Lohse
Nature Chemical Biology 4, 126–131
(February 2008); doi:10.1038/nchembio.64
| Summary | Full Text (HTML / PDF) |
article
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
Hui-Chen Hsu et al.
Nature Immunology 9, 166–175
(February 2008); doi:10.1038/ni1552
| Summary | Full Text (HTML / PDF) |
news and views
IL-17 drives germinal center B cells?
David Tarlinton
Nature Immunology 9, 124–126
(February 2008); doi:10.1038/ni0208-124
| Full Text (HTML / PDF) |
review
Ral GTPases and cancer: linchpin support of the tumorigenic platform
Brian O. Bodemann & Michael A. White
Nature Reviews Cancer 8, 133–140
(February 2008); doi:10.1038/nrc2296
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of the multifunctional Gβ5–RGS9 complex
Matthew L Cheever, Jason T Snyder, Svetlana Gershburg, David P Siderovski, T Kendall Harden & John Sondek
Nature Structural & Molecular Biology 15, 155–162
(February 2008); doi:10.1038/nsmb.1377
| Summary | Full Text (HTML / PDF) |
scientific report
Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation
Noritaka Yasuda et al.
EMBO Reports 9, 179–186
(February 2008); doi:10.1038/sj.embor.7401157
| Summary | Full Text (HTML / PDF) |
news and views
Worming our way to the fountain of youth
Peter John Roy
Nature Chemical Biology 4, 88–89
(February 2008); doi:10.1038/nchembio0208-88
| Full Text (HTML / PDF) |
January
letter
G12–G13–LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Angela Wirth et al.
Nature Medicine 14, 64–68
(January 2008); doi:10.1038/nm1666
| Summary | Full Text (HTML / PDF) |
news and views
Salt abuse: the path to hypertension
Wilhelm Schoner
Nature Medicine 14, 16–17
(January 2008); doi:10.1038/nm0108-16
| Summary | Full Text (HTML / PDF) |
article
Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling
Xiaoling Li, Xue Gao, Guofa Liu, Wencheng Xiong, Jane Wu & Yi Rao
Nature Neuroscience 11, 28–35
(January 2008); doi:10.1038/nn2022
| Summary | Full Text (HTML / PDF) |
review
Heterotrimeric G protein activation by G-protein-coupled receptors
William M. Oldham & Heidi E. Hamm
Nature Reviews Molecular Cell Biology 9, 60–71
(January 2008); doi:10.1038/nrm2299
| Summary | Full Text (HTML / PDF) |
article
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
Andrew M Tager et al.
Nature Medicine 14, 45–54
(January 2008); doi:10.1038/nm1685
| Summary | Full Text (HTML / PDF) |
news and views
From lung injury to fibrosis
Klaus Ley & Alexander Zarbock
Nature Medicine 14, 20–21
(January 2008); doi:10.1038/nm0108-20
| Summary | Full Text (HTML / PDF) |
letter
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
Masaki Morishige et al.
Nature Cell Biology 10, 85–92
(January 2008); doi:10.1038/ncb1672
| Summary | Full Text (HTML / PDF) |
news and views
Getting invasive with GEP100 and Arf6
Ferran Valderrama & Anne J. Ridley
Nature Cell Biology 10, 16–18
(January 2008); doi:10.1038/ncb0108-16
| Summary | Full Text (HTML / PDF) |
article
ARF1 is directly involved in dynamin-independent endocytosis
Sudha Kumari & Satyajit Mayor
Nature Cell Biology 10, 30–41
(January 2008); doi:10.1038/ncb1666
| Summary | Full Text (HTML / PDF) |
article
Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13
Geetanjali Bansal, Zhihui Xie, Sudhir Rao, Karl H Nocka & Kirk M Druey
Nature Immunology 9, 73–80
(January 2008); doi:10.1038/ni1533
| Summary | Full Text (HTML / PDF) |
article
A receptor that mediates the post-mating switch in Drosophila reproductive behaviour
Nilay Yapici, Young-Joon Kim, Carlos Ribeiro & Barry J. Dickson
Nature 451, 33–37
(3 January 2008); doi:10.1038/nature06483
| Summary | Full Text (HTML / PDF) |
review
Salmonellae interplay with host cells
Andrea Haraga, Maikke B. Ohlson & Samuel I. Miller
Nature Reviews Microbiology 6, 53–66
(January 2008); doi:10.1038/nrmicro1788
| Summary | Full Text (HTML / PDF) |
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