Research library: Apoptosis
2002: December
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December
article
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
Yonglian Sun, Helen M. Chen, Sumit K. Subudhi, Jonathan Chen, Rima Koka, Lieping Chen and Yang-Xin Fu
Nature Medicine 8, 1405–1413
(December 2002); doi:10.1038/nm796
| Abstract | Full Text (HTML/PDF) |
news and views
Immunotherapy tackles lupus
Gary M. Kammer
Nature Medicine 8, 1356–1358
(December 2002); doi:10.1038/nm1202-1356
| Full Text (HTML/PDF) |
article
T cells require TRAIL for optimal graft-versus-tumor activity
Cornelius Schmaltz, Onder Alpdogan, Barry J. Kappel, Stephanie J. Muriglan, Jimmy A. Rotolo, Jennifer Ongchin, Lucy M. Willis, Andrew S. Greenberg, Jeffrey M. Eng, James M. Crawford, George F. Murphy, Hideo Yagita, Henning Walczak, Jacques J. Peschon and Marcel R.M. van den Brink
Nature Medicine 8, 1433–1437
(December 2002); doi:10.1038/nm797
| Abstract | Full Text (HTML/PDF) |
review article
The many faces of tumor necrosis factor in stroke
John M. Hallenbeck
Nature Medicine 8, 1363–1368
(December 2002); doi:10.1038/nm1202-1363
| Full Text (HTML/PDF) |
brief communication
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
Hector Valderrama-Carvajal, Eftihia Cocolakis, Annie Lacerte, Eun-Hye Lee, Gerald Krystal, Suhad Ali and Jean-Jacques Lebrun
Nature Cell Biology 4, 963–969
(December 2002); doi:10.1038/ncb885
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review article
A blast from the past: clearance of apoptotic cells regulates immune responses
John Savill, Ian Dransfield, Chris Gregory and Chris Haslett
Nature Reviews Immunology 2, 965–975
(December 2002); doi:10.1038/nri957
| Summary | Full Text (HTML / PDF) |
news and views
Tumour suppression: something for nothing?
Elisa de Stanchina and Scott W. Lowe
Nature Cell Biology 4, E275
(December 2002); doi:10.1038/ncb1202-e275
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November
article
BID regulation by p53 contributes to chemosensitivity
Joanna K. Sax, Peiwen Fei, Maureen E. Murphy, Eric Bernhard, Stanley J. Korsmeyer and Wafik S. El-Deiry
Nature Cell Biology 4, 842–849
(November 2002); doi:10.1038/ncb866
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article
Direct coupling of the cell cycle and cell death machinery by E2F
Zaher Nahle, Julia Polakoff, Ramana V. Davuluri, Mila E. McCurrach, Matthew D. Jacobson, Masashi Narita, Michael Q. Zhang, Yuri Lazebnik, Dafna Bar-Sagi and Scott W. Lowe
Nature Cell Biology 4, 859–864
(November 2002); doi:10.1038/ncb868
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review article
Natural selection of tumor variants in the generation of “tumor escape” phenotypes
Hung T. Khong and Nicholas P. Restifo
Nature Immunology 3, 999–1005
(November 2002); doi:10.1038/ni1102-999
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review
Neuroprotective and neurorestorative strategies for Parkinson's disease
Ted M. Dawson and Valina L. Dawson
Nature Neuroscience 5, 1058–1061
(November 2002); doi:10.1038/nn941
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review article
To kill or be killed: viral evasion of apoptosis
Chris A. Benedict, Paula S. Norris and Carl F. Ware
Nature Immunology 3, 1013–1018
(November 2002); doi:10.1038/ni1102-1013
| Abstract | Full Text (HTML/PDF) |
original paper
Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells
Wendy J Ingram, Carol A Wicking, Sean M Grimmond, Alistair R Forrest and Brandon J Wainwright
Oncogene 21, 8196–8205
(November 2002); doi:10.1038/sj.onc.1205975
| Abstract |
brief communication
NF-kB2 p100 is a pro-apoptotic protein with anti-oncogenic function
Yongqing Wang, Hongjuan Cui, Allen Schroering, Jane L. Ding, William S. Lane, Gaël McGill, David E. Fisher and Han-Fei Ding
Nature Cell Biology 4, 888–893
(November 2002); doi:10.1038/ncb872
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review article
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
Georg Dechant and Yves-Alain Barde
Nature Neuroscience 5, 1131–1136
(November 2002); doi:10.1038/nn1102-1131
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review article
Lymphocide: cytokines and the control of lymphoid homeostasis
Annette R. Khaled and Scott K. Durum
Nature Reviews Immunology 2, 817–830
(November 2002); doi:10.1038/nri931
| Summary | Full Text (HTML / PDF) |
original paper
The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2
M Adachi and K Imai
Cell death and differentiation 9, 1240–1247
(November 2002); doi:10.1038/sj.cdd.4401097
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October
letters to nature
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
Hongwu Zheng, Han You, Xiao Zhen Zhou, Stephen A. Murray, Takafumi Uchida, Gerburg Wulf, Ling Gu, Xiaoren Tang, Kun Ping Lu and Zhi-Xiong Jim Xiao
Nature 419, 849–853
(24 October 2002); doi:10.1038/nature01116
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letters to nature
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
Paola Zacchi , Monica Gostissa, Takafumi Uchida, Clio Salvagno, Fabio Avolio, Stefano Volinia, Ze'ev Ronai, Giovanni Blandino, Claudio Schneider and Giannino Del Sal
Nature 419, 853–857
(24 October 2002); doi:10.1038/nature01120
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news and views
Cancer: Pinning a change on p53
Kevin M. Ryan and Karen H. Vousden An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.
Nature 419, 795–797
(24 October 2002); doi:10.1038/419795a
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news and views
Cell biology: Survival in three dimensions
Kenneth M. Yamada and Katherine Clark Whether a cell lives or dies depends on various local cues. New work reveals that those cues include a cell's spatial relationship with its neighbours and polarized interactions with the adjacent extracellular matrix.
Nature 419, 790–791
(24 October 2002); doi:10.1038/419790a
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letters to nature
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
Joan Seoane, Hong-Van Le and Joan Massagué
Nature 419, 729–734
(17 October 2002); doi:10.1038/nature01119
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review article
c-myc: more than just a matter of life and death
Stella Pelengaris, Mike Khan and Gerard Evan
Nature Reviews Cancer 2, 764–776
(October 2002); doi:10.1038/nrc904
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review article
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
Toby Lawrence, Derek A. Willoughby and Derek W. Gilroy
Nature Reviews Immunology 2, 787–795
(October 2002); doi:10.1038/nri915
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review article
How death shapes life during development
Eric H. Baehrecke
Nature Reviews Molecular Cell Biology 3, 779–787
(October 2002); doi:10.1038/nrm931
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article
Evidence for two apoptotic pathways in light-induced retinal degeneration
Wenshan Hao, Andreas Wenzel, Martin S. Obin, Ching-Kang Chen, Elliott Brill, Nataliia V. Krasnoperova, Pamela Eversole-Cire, Yelena Kleyner, Allen Taylor, Melvin I. Simon, Christian Grimm, Charlotte E. Remé and Janis Lem
Nature Genetics 32, 254–260
(October 2002); doi:10.1038/ng984
| Abstract | Full Text (HTML/PDF) |
news and views
Blinded by the light
Samuel G. Jacobson and Roderick R. McInnes
Nature Genetics 32, 215–216
(October 2002); doi:10.1038/ng1002-215
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letters to nature
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Vanessa S. Marsden, Liam O'Connor, Lorraine A. O'Reilly, John Silke, Donald Metcalf, Paul G. Ekert, David C. S. Huang, Francesco Cecconi, Keisuke Kuida, Kevin J. Tomaselli, Sophie Roy, Don W. Nicholson, David L. Vaux, Philippe Bouillet, Jerry M. Adams and Andreas Strasser
Nature 419, 634–637
(10 October 2002); doi:10.1038/nature01101
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article
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
Judith Haendeler, Jörg Hoffmann, Verena Tischler, Bradford C. Berk, Andreas M. Zeiher and Stefanie Dimmeler
Nature Cell Biology 4, 743–749
(October 2002); doi:10.1038/ncb851
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article
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
B. Nelson Chau, Helena Lobo Borges, Tung-Ti Chen, Anja Masselli, Irina C. Hunton and Jean Y. J. Wang
Nature Cell Biology 4, 757–765
(October 2002); doi:10.1038/ncb853
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news and views
Two faces of caspase-8
Bryan C. Barnhart and Marcus E. Peter
Nature Immunology 3, 896–898
(October 2002); doi:10.1038/ni1002-896
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review article
Functional significance of the perforin/granzyme cell death pathway
Joseph A. Trapani and Mark J. Smyth
Nature Reviews Immunology 2, 735–747
(October 2002); doi:10.1038/nri911
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letter
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
Juan A. Bernal, Rosa Luna, Águeda Espina, Icíar Lázaro, Francisco Ramos-Morales, Francisco Romero, Carmen Arias, Augusto Silva, María Tortolero and José A. Pintor-Toro
Nature Genetics 32, 306–311
(October 2002); doi:10.1038/ng997
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news and views
Securin a new role for itself
Anil K. Rustgi
Nature Genetics 32, 222–224
(October 2002); doi:10.1038/ng1002-222
| Full Text (HTML/PDF) |
review article
The Yersinia Ysc-Yop 'Type III' weaponry
Guy R. Cornelis
Nature Reviews Molecular Cell Biology 3, 742–754
(October 2002); doi:10.1038/nrm932
| Summary | Full Text (HTML / PDF) |
article
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
Jeffrey C. Rathmell, Tullia Lindsten, Wei-Xing Zong, Ryan M. Cinalli and Craig B. Thompson
Nature Immunology 3, 932–939
(October 2002); doi:10.1038/ni834
| Abstract | Full Text (HTML/PDF) |
news and views
Bax and Bak: back-bone of T cell death
Philippe Bouillet and Andreas Strasser
Nature Immunology 3, 893–894
(October 2002); doi:10.1038/ni1002-893
| Full Text (HTML/PDF) |
review article
Regulation of mast-cell and basophil function and survival by IgE
Toshiaki Kawakami and Stephen J. Galli
Nature Reviews Immunology 2, 773–786
(October 2002); doi:10.1038/nri914
| Summary | Full Text (HTML / PDF) |
original paper
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain
V Cowling & J Downward
Cell Death and Differentiation 9, 1046–1056
(October 2002); doi:10.1038/sj.cdd.4401065
| Abstract |
September
article
The harlequin mouse mutation downregulates apoptosis-inducing factor
Jeffrey A. Klein, Chantal M. Longo-Guess, Marlies P. Rossmann, Kevin L. Seburn, Ronald E. Hurd, Wayne N. Frankel, Roderick T. Bronson and Susan L. Ackerman
Nature 419, 367–374
(26 September 2002); doi:10.1038/nature01034
| Summary | Full Text (HTML / PDF) |
letters to nature
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
Hyung J. Chun, Lixin Zheng, Manzoor Ahmad, Jin Wang, Christina K. Speirs, Richard M. Siegel, Janet K. Dale, Jennifer Puck, Joie Davis, Craig G. Hall, Suzanne Skoda-Smith, T. Prescott Atkinson, Stephen E. Straus and Michael J. Lenardo
Nature 419, 395–399
(26 September 2002); doi:10.1038/nature01063
| First Paragraph | Full Text (HTML / PDF) |
commentary
A reevaluation of integrins as regulators of angiogenesis
Richard O. Hynes
Nature Medicine 8, 918–921
(September 2002); doi:10.1038/nm0902-918
| Full Text (HTML/PDF) |
review article
The bcl2 family: regulators of the cellular life-or-death switch
Suzanne Cory and Jerry M. Adams
Nature Reviews Cancer 2, 647–656
(September 2002); doi:10.1038/nrc883
| Summary | Full Text (HTML / PDF) |
letter
Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts
Patricia Hess, German Pihan, Charles L. Sawyers, Richard A. Flavell and Roger J. Davis
Nature Genetics 32, 201–205
(September 2002); doi:10.1038/ng946
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letters to nature
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Geert J. P. L. Kops, Tobias B. Dansen, Paulien E. Polderman, Ingrid Saarloos, Karel W. A. Wirtz, Paul J. Coffer, Ting-T. Huang, Johannes L. Bos, René H. Medema and Boudewijn M. T. Burgering
Nature 419, 316–321
(19 September 2002); doi:10.1038/nature01036
| First Paragraph | Full Text (HTML / PDF) |
brief communication
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila
Erina Kuranaga, Hirotaka Kanuka, Tatsushi Igaki, Kazunobu Sawamoto, Hidenori Ichijo, Hideyuki Okano and Masayuki Miura
Nature Cell Biology 4, 705–710
(September 2002); doi:10.1038/ncb842
| First Paragraph | Full Text (HTML/PDF) |
review article
Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways
Kathleen A. Gallo and Gary L. Johnson
Nature Reviews Molecular Cell Biology 3, 663–672
(September 2002); doi:10.1038/nrm906
| Abstract | Full Text (HTML/PDF) |
review article
Signalling: Seven-transmembrane receptors
Kristen L. Pierce, Richard T. Premont and Robert J. Lefkowitz
Nature Reviews Molecular Cell Biology 3, 639–650
(September 2002); doi:10.1038/nrm908
| Summary | Full Text (HTML / PDF) |
article
Inhibitor of apoptosis protein survivin regulates vascular injury
Olivier P. Blanc-Brude, Jun Yu, Hector Simosa, Michael S. Conte, William C. Sessa and Dario C. Altieri
Nature Medicine 8, 987–994
(September 2002); doi:10.1038/nm750
| Abstract | Full Text (HTML/PDF) |
original paper
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis
S B Bratton, J Lewis, M Butterworth, C S Duckett & G M Cohen
Cell Death and Differentiation 9, 881–892
(September 2002); doi:10.1038/sj.cdd.4401069
| Abstract |
August
news and views
Apoptosis: Sculpture of a fly's head
Jun R. Huh and Bruce A. Hay
Nature 418, 926–928
(29 August 2002); doi:10.1038/418926a
| Full Text (HTML / PDF) |
article
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis and Lieping Chen
Nature Medicine 8, 793–800
(August 2002); doi:10.1038/nm730
| Abstract | Full Text (HTML/PDF) |
news and views
Protect the killer: CTLs need defenses against the tumor
Gordon J. Freeman, Arlene H. Sharpe and Vijay K. Kuchroo
Nature Medicine 8, 787–789
(August 2002); doi:10.1038/nm0802-787
| Full Text (HTML/PDF) |
review article
Live or let die: the cell's response to p53
Karen H. Vousden and Xin Lu
Nature Reviews Cancer 2, 594–604
(August 2002); doi:10.1038/nrc864
| Summary | Full Text (HTML / PDF) |
original paper
Activation of NF-KAPPAB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications
C.S. Mitsiades, N. Mitsiades, V. Poulaki, R. Schlossman, M. Akiyama, D. Chauhan, T. Hideshima, S.P. Treon, N.C. Munshi, P.G. Richardson, K.C. Anderson
Oncogene 21, 5673–5683
(August 2002); doi:10.1038/sj.onc.1205664
| Abstract |
review article
p73: Friend or foe in tumorigenesis
Gerry Melino, Vincenzo De Laurenzi and Karen H. Vousden
Nature Reviews Cancer 2, 605–615
(August 2002); doi:10.1038/nrc861
| Abstract | Full Text (HTML/PDF) |
Original Paper
Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation
DeChant A.K., Dee K. and Weyman C.M.
Oncogene 21, 5268–5279
(8 August 2002); doi:10.1038/sj.onc.1205648
| Abstract |
Original Paper
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death
Castro-Obregón S., del Rio G., Chen S.F., Swanson R.A., Frankowski H., Rao R.V., Stoka V., Vesce S., Nicholls D.G. and Bredesen D.E.
Cell Death and Differentiation 9, 807–817
(August 2002); doi:10.1038/sj.cdd.4401035
| Abstract |
article
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
Simone Fulda, Wolfgang Wick, Michael Weller and Klaus-Michael Debatin
Nature Medicine 8, 808–815
(August 2002); doi:10.1038/nm735
| Abstract | Full Text (HTML/PDF) |
July
article
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
Christian Grimm, Andreas Wenzel, Matthias Groszer, Helmut Mayser, Mathias Seeliger, Marijana Samardzija, Christian Bauer, Max Gassmann and Charlotte E. Remé
Nature Medicine 8, 718–724
(July 2002); doi:10.1038/nm723
| Abstract | Full Text (HTML/PDF) |
article
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy
Martin G. Yussman, Tsuyoshi Toyokawa, Amy Odley, Roy A. Lynch, Guangyu Wu, Melissa C. Colbert, Bruce J. Aronow, John N. Lorenz, Gerald W. Dorn and Gerald W. Dorn II
Nature Medicine 8, 725–730
(July 2002); doi:10.1038/nm719
| Abstract | Full Text (HTML/PDF) |
news and views
Burning up TNF toxicity for cancer therapy
Marcel Leist and Marja Jäättelä
Nature Medicine 8, 667–668
(July 2002); doi:10.1038/nm0702-667
| Full Text (HTML/PDF) |
letter to nature
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Paola Scaffidi, Tom Misteli and Marco E. Bianchi
Nature 418, 191–195
(11 July 2002); doi:10.1038/nature00858
| First Paragraph | Full Text (HTML/PDF) |
letter to nature
Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
Simon Brown, Isabelle Heinisch, Ewan Ross, Kate Shaw, Chris D. Buckley and John Savill
Nature 418, 200–203
(11 July 2002); doi:10.1038/nature00811
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news and views
Apoptosis: Repulsive encounters
Giovanna Chimini
Nature 418, 139–141
(11 July 2002); doi:10.1038/418139a
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June
commentary
With a little help from your friends: cells don't die alone
Barbara Conradt
Nature Cell Biology 4, E139
(June 2002); doi:10.1038/ncb0602-e139
| Full Text (HTML/PDF) |
article
Dopamine-dependent neurotoxicity of a-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
Jin Xu, Shyan-Yuan Kao, Frank J.S. Lee, Weihong Song, Lee-Way Jin and Bruce A. Yankner
Nature Medicine 8, 600–606
(June 2002); doi:10.1038/nm0602-600
| Abstract | Full Text (HTML/PDF) |
news and views
Releasing the nerve cell killers
Kevin Welch and Junying Yuan
Nature Medicine 8, 564–565
(June 2002); doi:10.1038/nm0602-564
| Full Text (HTML/PDF) |
news and views
p53 de-ubiquitination: at the edge between life and death
Paolo Salomoni and Pier Paolo Pandolfi
Nature Cell Biology 4, E152
(June 2002); doi:10.1038/ncb0602-e152
| Full Text (HTML/PDF) |
news and views
The 3D's of apoptosis: death, degradation and DIAPs
Tanapat Palaga and Barbara Osborne
Nature Cell Biology 4, E149
(June 2002); doi:10.1038/ncb0602-e149
| Full Text (HTML/PDF) |
article
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
Soon Ji Yoo, Jun R. Huh, Israel Muro, Hong Yu, Lijuan Wang, Susan L. Wang, R. M. Renny Feldman, Rollie J. Clem, H.-Arno J. Müller and Bruce A. Hay
Nature Cell Biology 4, 416–424
(June 2002); doi:10.1038/ncb793
| Abstract | Full Text (HTML/PDF) |
article
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
Rebecca Hays, Laura Wickline and Ross Cagan
Nature Cell Biology 4, 425–431
(June 2002); doi:10.1038/ncb794
| Abstract | Full Text (HTML/PDF) |
article
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
Hyung Don Ryoo, Andreas Bergmann, Hedva Gonen, Aaron Ciechanover and Hermann Steller
Nature Cell Biology 4, 432–438
(June 2002); doi:10.1038/ncb795
| Abstract | Full Text (HTML/PDF) |
brief communication
Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition
Christopher L. Holley, Michael R. Olson, Daniel A. Colón-Ramos and Sally Kornbluth
Nature Cell Biology 4, 439–444
(June 2002); doi:10.1038/ncb798
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brief communication
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
Rebecca Wilson, Lakshmi Goyal, Mark Ditzel, Anna Zachariou, David A. Baker, Julie Agapite, Hermann Steller and Pascal Meier
Nature Cell Biology 4, 445–450
(June 2002); doi:10.1038/ncb799
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brief communication
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
John P. Wing, Barbara A. Schreader, Takakazu Yokokura, Yiqin Wang, Paul S. Andrews, Neda Huseinovic, Carolyn K. Dong, Justyne L. Ogdahl, Lawrence M. Schwartz, Kristin White and John R. Nambu
Nature Cell Biology 4, 451–456
(June 2002); doi:10.1038/ncb800
| First Paragraph | Full Text (HTML/PDF) |
news and views
Mini p53
Valerie Ferrier
Nature Cell Biology 4, E156
(June 2002); doi:10.1038/ncb0602-e156
| Full Text (HTML/PDF) |
meeting report
Life and death in paradise
Or Gozani, Michael Boyce, Lina Yoo, Philip Karuman and Junying Yuan
Nature Cell Biology 4, E159
(June 2002); doi:10.1038/ncb0602-e159
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Opinion: Yeast and apoptosis
Can Jin and John C. Reed
Nature Reviews Molecular Cell Biology 3, 453–459
(June 2002); doi:10.1038/nrm832
| Abstract | Full Text (HTML/PDF) |
review article
Cytotoxic t lymphocytes: all roads lead to death
Michele Barry and R. Chris Bleackley
Nature Reviews Immunology 2, 401–409
(June 2002); doi:10.1038/nri819
| Abstract | Full Text (HTML/PDF) |
review article
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Avi Ashkenazi
Nature Reviews Cancer 2, 420–430
(June 2002); doi:10.1038/nrc821
| Abstract | Full Text (HTML/PDF) |
review article
Apoptosis: IAP proteins: blocking the road to death's door
Guy S. Salvesen and Colin S. Duckett
Nature Reviews Molecular Cell Biology 3, 401–410
(June 2002); doi:10.1038/nrm830
| Abstract | Full Text (HTML/PDF) |
brief communication
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
Jing Li, Ying Yang, Yue Peng, Richard J. Austin, Winfried G. van Eyndhoven, Ken C. Q. Nguyen, Tim Gabriele, Mila E. McCurrach, Jeffrey R. Marks, Timothy Hoey, Scott W. Lowe & Scott Powers
Nature Genetics 31, 133–134
(June 2002); doi:10.1038/ng888
| First Paragraph | Full Text (HTML/PDF) |
letter
The crystal structure of the mouse apoptosis-inducing factor AIF
María J. Maté, Miguel Ortiz-Lombardía, Brigitte Boitel, Ahmed Haouz, Diana Tello, Santos A. Susin, Josef Penninger, Guido Kroemer and Pedro M. Alzari
Nature Structural Biology 9, 442–446
(June 2002); doi:10.1038/nsb793
| First Paragraph | Full Text (HTML/PDF) |
letter
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
Wenyu Li, Srinivasa M. Srinivasula, Jijie Chai, Pingwei Li, Jia-Wei Wu, ZhiJia Zhang, Emad S. Alnemri & Yigong Shi
Nature Structural Biology 9, 436–441
(June 2002); doi:10.1038/nsb795
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news and views
Love it or cleave it: Tough choices in protein quality control
Michael R. Maurizi
Nature Structural Biology 9, 410–412
(June 2002); doi:10.1038/nsb0602-410
| Full Text (HTML/PDF) |
May
letters to nature
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Shan Zhu, Irina G. Stavrovskaya, Martin Drozda, Betty Y. S. Kim, Victor Ona, Mingwei Li, Satinder Sarang, Allen S. Liu, Dean M. Hartley, Du Chu Wu, Steven Gullans, Robert J. Ferrante, Serge Przedborski, Bruce S. Kristal and Robert M. Friedlander
Nature 417, 74–78
(May 2002); doi:10.1038/417074a
| First Paragraph | Full Text (HTML/PDF) |
research article
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
Paolo Michieli, Silvia Cavassa, Cristina Basilico, Annarita De Luca, Massimiliano Mazzone, Cinzia Asti, Riccardo Chiusaroli, Mario Guglielmi, Paola Bossù, Francesco Colotta, Gianfranco Caselli and Paolo M. Comoglio
Nature Biotechnology 20, 488–495
(May 2002); doi:10.1038/nbt0502-488
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article
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Giles E. Hardingham, Yuko Fukunaga and Hilmar Bading
Nature Neuroscience 5, 405–414
(May 2002); doi:10.1038/nn835
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What a privilege to reside at the synapse: NMDA receptor signaling to CREB
Antonella Riccio and David D. Ginty
Nature Neuroscience 5, 389–390
(May 2002); doi:10.1038/nn0502-389
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review article
ONCOGENIC TYROSINE KINASES AND THE DNA-DAMAGE RESPONSE
Tomasz Skorski
Nature Reviews Cancer 2, 351–360
(May 2002); doi:10.1038/nrc799
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April
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Mitochondria, from cell death to proliferation
Pierre Rustin
Nature Genetics 30, 352–353
(April 2002); doi:10.1038/ng0402-352
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article
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
Olga V. Volpert, Tetiana Zaichuk, Wei Zhou, Frank Reiher, Thomas A. Ferguson, P. Michael Stuart, Mohammad Amin and Noel P. Bouck
Nature Medicine 8, 349–357
(April 2002); doi:10.1038/nm0402-349
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research article
Identification of genes that function in the TNF-a-mediated apoptotic pathway using randomized hybrid ribozyme libraries
Hiroaki Kawasaki, Reiko Onuki, Eigo Suyama and Kazunari Taira
Nature Biotechnology 20, 376–380
(April 2002); doi:10.1038/nbt0402-376
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review article
DEATH AND ANTI-DEATH: TUMOUR RESISTANCE TO APOPTOSIS
Frederik H. Igney and Peter H. Krammer
Nature Reviews Cancer 2, 277–288
(April 2002); doi:10.1038/nrc776
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letters to nature
Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
Eduardo Moreno, Konrad Basler and Ginés Morata
Nature 416, 755–759
(April 2002); doi:10.1038/416755a
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letters to nature
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
Elsa R. Flores, Kenneth Y. Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon and Tyler Jacks
Nature 416, 560–564
(April 2002); doi:10.1038/416560a
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March
review article
AUTOIMMUNE THYROID DISEASE: NEW MODELS OF CELL DEATH IN AUTOIMMUNITY
Giorgio Stassi and Ruggero De Maria
Nature Reviews Immunology 2, 195–204
(March 2002); doi:10.1038/nri750
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article
Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
Heidi LeBlanc, David Lawrence, Eugene Varfolomeev, Klara Totpal, John Morlan, Peter Schow, Sharon Fong, Ralph Schwall, Dominick Sinicropi and Avi Ashkenazi
Nature Medicine 8, 274–281
(March 2002); doi:10.1038/nm0302-274
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Apoptosis and cancer: When BAX is TRAILing away
Wilfried Roth and John C. Reed
Nature Medicine 8, 216–218
(March 2002); doi:10.1038/nm0302-216
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letters to nature
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Xiaoming Li, Yili Yang and Jonathan D. Ashwell
Nature 416, 345–347
(March 2002); doi:10.1038/416345a
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February
review article
APOPTOSIS-BASED THERAPIES
John C. Reed
Nature Reviews Drug Discovery 1, 111–121
(February 2002); doi:10.1038/nrd726
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review article
DEADLY ENCOUNTER: UBIQUITIN MEETS APOPTOSIS
Veronika Jesenberger and Stefan Jentsch
Nature Reviews Molecular Cell Biology 3, 112–121
(February 2002); doi:10.1038/nrm731
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Hip, Hip, Hippi!
Valerie Ferrier
Nature Cell Biology 4, E30
(February 2002); doi:10.1038/ncb0202-e30
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article
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
François G. Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R. Leavitt, Martina Metzler, Abigail S. Hackam, John Tam, John P. Vaillancourt, Vicky Houtzager, Dita M. Rasper, Sophie Roy, Michael R. Hayden and Donald W. Nicholson
Nature Cell Biology 4, 95–105
(February 2002); doi:10.1038/ncb735
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brief communication
IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo
D. Perrelet, A. Ferri, P. Liston, P. Muzzin, R.G. Korneluk and A. C. Kato
Nature Cell Biology 4, 175–179
(February 2002); doi:10.1038/ncb751
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letters to nature
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Philippe Bouillet, Jared F. Purton, Dale I. Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, Marc Pellegrini, Suzanne Cory, Jerry M. Adams and Andreas Strasser
Nature 415, 922–926
(February 2002); doi:10.1038/415922a
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review article
APOPTOSIS-BASED THERAPIES
John C. Reed
Nature Reviews Drug Discovery 1, 111–121
(February 2002); doi:10.1038/nrd726
| Abstract | Full Text (HTML/PDF) |
review article
DEADLY ENCOUNTER: UBIQUITIN MEETS APOPTOSIS
Veronika Jesenberger and Stefan Jentsch
Nature Reviews Molecular Cell Biology 3, 112–121
(February 2002); doi:10.1038/nrm731
| Abstract | Full Text (HTML/PDF) |
article
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
François G. Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R. Leavitt, Martina Metzler, Abigail S. Hackam, John Tam, John P. Vaillancourt, Vicky Houtzager, Dita M. Rasper, Sophie Roy, Michael R. Hayden and Donald W. Nicholson
Nature Cell Biology 4, 95–105
(February 2002); doi:10.1038/ncb735
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letters to nature
S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
Hiroshi Masumoto, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki
Nature 415, 651–655
(February 2002); doi:10.1038/nature713
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January
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Huntington's disease: Accomplices to neuronal death
Mark P. Mattson
Nature 415, 377–379
(January 2002); doi:10.1038/415377a
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article
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
Gabriella D'Orazi, Barbara Cecchinelli, Tiziana Bruno, Isabella Manni, Yuichiro Higashimoto, Shin'ichi Saito, Monica Gostissa, Sabrina Coen, Alessandra Marchetti, Giannino Del Sal, Giulia Piaggio, Maurizio Fanciulli, Ettore Appella and Silvia Soddu
Nature Cell Biology 4, 11–19
(January 2002); doi:10.1038/ncb714
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article
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
Thomas G. Hofmann, Andreas Möller, Hüseyin Sirma, Hanswalter Zentgraf, Yoichi Taya, Wulf Dröge, Hans Will and M. Lienhard Schmitz
Nature Cell Biology 4, 1–10
(January 2002); doi:10.1038/ncb715
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article
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
Agatha Schwarz, Sonja Ständer, Mark Berneburg, Markus Böhm, Dagmar Kulms, Harry van Steeg, Karin Grosse-Heitmeyer, Jean Krutmann and
Nature Cell Biology 4, 26–31
(January 2002); doi:10.1038/ncb717
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article
TGF-b induces apoptosis through Smad-mediated expression of DAP-kinase
Chuan-Wei Jang, Chun-Hau Chen, Chun-Chieh Chen, Jia-yun Chen, Yi-Hsien Su and Ruey-Hwa Chen
Nature Cell Biology 4, 51–58
(January 2002); doi:10.1038/ncb731
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article
Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils
Isabelle Daigle, Shida Yousefi, Marco Colonna, Douglas R. Green and Hans-Uwe Simon
Nature Medicine 8, 61–67
(January 2002); doi:10.1038/nm0102-61
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article
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
Marc A. Gavin, Sally R. Clarke, Ella Negrou, Alena Gallegos and Alexander Rudensky
Nature Immunology 3, 33–41
(January 2002); doi:10.1038/ni743
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letter
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
Gerard Zambetti and Richard W. Kriwacki
Nature Structural Biology 9, 12–16
(January 2002); doi:10.1038/nsb730
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