Research library: Apoptosis
2003: December
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December
letter
Mitochondrial translocation of cofilin is an early step in apoptosis induction
Boon Tin Chua, Christiane Volbracht, Kuan Onn Tan, Rong Li, Victor C. Yu and Peng Li
Nature Cell Biology 5, 1083–1089
(December 2003); doi:10.1038/ncb1070
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letters to nature
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Joseph T. Opferman, Anthony Letai, Caroline Beard, Mia D. Sorcinelli, Christy C. Ong and Stanley J. Korsmeyer
Nature 426, 671–676
(11 December 2003); doi:10.1038/nature02067
| First Paragraph | Full Text (HTML / PDF) |
review article
The 14-3-3 cancer connection
Heiko Hermeking
Nature Reviews Cancer 3, 931–943
(December 2003); doi:10.1038/nrc1230
| Abstract | Full Text (HTML / PDF) |
article
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
Darren Boehning, Randen L. Patterson, Leela Sedaghat, Natalia O. Glebova, Tomohiro Kurosaki and Solomon H. Snyder
Nature Cell Biology 5, 1051–1061
(December 2003); doi:10.1038/ncb1063
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news and views
Calcium orchestrates apoptosis
Mark P. Mattson and Sic L. Chan
Nature Cell Biology 5, 1041–1043
(December 2003); doi:10.1038/ncb1203-1041
| Full Text (HTML/PDF) |
letter
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency
William A Irwin, Natascha Bergamin, Patrizia Sabatelli, Carlo Reggiani, Aram Megighian, Luciano Merlini, Paola Braghetta, Marta Columbaro, Dino Volpin, Giorgio M Bressan, Paolo Bernardi and Paolo Bonaldo
Nature Genetics 35, 367–371
(December 2003); doi:10.1038/ng1270
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news and views
The collagen-mitochondria connection
Rosario Rizzuto
Nature Genetics 35, 300–301
(December 2003); doi:10.1038/ng1203-300
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news and views
Histone H1.2 as a trigger for apoptosis
Nieng Yan and Yigong Shi
Nature Structural Biology 10, 983–985
(December 2003); doi:10.1038/nsb1203-983
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November
article
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Jijie Chai, Nieng Yan, Jun R. Huh, Jia-Wei Wu, Wenyu Li, Bruce A. Hay and Yigong Shi
Nature Structural Biology 10, 892–898
(November 2003); doi:10.1038/nsb989
| Abstract | Full Text (HTML/PDF) |
review article
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Peter M. Siegel and Joan Massagué
Nature Reviews Cancer 3, 807–820
(November 2003); doi:10.1038/nrc1208
| Abstract | Full Text (HTML / PDF) |
article
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
Rong Rong, Jee-Yin Ahn, Honglian Huang, Eiichiro Nagata, Daniel Kalman, Judith A Kapp, Jiancheng Tu, Paul F Worley, Solomon H Snyder and Keqiang Ye
Nature Neuroscience 6, 1153–1161
(November 2003); doi:10.1038/nn1134
| Abstract | Full Text (HTML/PDF) |
October
letter
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
Sophie Pantalacci, Nicolas Tapon and Pierre Léopold
Nature Cell Biology 5,921–927
(October 2003); doi:10.1038/ncb1051
| Abstract
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letter
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
Ryan S. Udan, Madhuri Kango-Singh, Riitta Nolo, Chunyao Tao and Georg Halder
Nature Cell Biology 5, 914–920
(October 2003); doi:10.1038/ncb1050
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news and views
Hippo and its mission for growth control
Hyung Don Ryoo and Hermann Steller
Nature Cell Biology 5, 853–855
(October 2003); doi:10.1038/ncb1003-853
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review article
Cell-death alternative model organisms: why and which?
Pierre Golstein, Laurence Aubry and Jean-Pierre Levraud
Nature Reviews Molecular Cell Biology 4, 798–807
(October 2003); doi:10.1038/nrm1224
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article
HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
Kunyan Zhang, G. Angus McQuibban, Claudia Silva, Georgina S. Butler, James B. Johnston, Janet Holden, Ian Clark-Lewis, Christopher M. Overall and Christopher Power
Nature Neuroscience 6, 1064–1071
(October 2003); doi:10.1038/nn1127
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news and views
Snip-snip, kill-kill: truncated SDF-1 and HIV-associated neurodegeneration
Richard M. Ransohoff
Nature Neuroscience 6, 1009–1011
(October 2003); doi:10.1038/nn1003-1009
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news and views
Cell biology: The hippo hypothesis
Michael E. Rothenberg and Yuh-Nung Jan
Nature 425, 469–470
(02 October 2003); doi:10.1038/425469a
| Full Text (HTML / PDF) |
September
letters to nature
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz, Kevin J. Bitterman, Haim Y. Cohen, Dudley W. Lamming, Siva Lavu, Jason G. Wood, Robert E. Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang, Brandy Scherer and David A. Sinclair
Nature 425, 191–196
(11 September 2003); doi:10.1038/nature01960
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news and views
Ageing: A toast to long life
Toren Finkel
Nature 425, 132–133
(11 September 2003); doi:10.1038/425132a
| Full Text (HTML / PDF) |
review article
Signalling pathways of the TNF superfamily: a double-edged sword
Bharat B. Aggarwal
Nature Reviews Immunology 3, 745–756
(September 2003); doi:10.1038/nri1184
| Abstract | Full Text (HTML / PDF) |
review article
14-3-3 proteins in the nervous system
Daniela Berg , Carsten Holzmann and Olaf Riess
Nature Reviews Neuroscience 4, 752–762
(September 2003); doi:10.1038/nrn1197
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article
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
Bo Feng, Pin Mei Yao, Yankun Li, Cecilia M. Devlin, Dajun Zhang, Heather P. Harding, Michele Sweeney, James X. Rong, George Kuriakose, Edward A. Fisher, Andrew R. Marks, David Ron and Ira Tabas
Nature Cell Biology 5, 781–792
(September 2003); doi:10.1038/ncb1035
| Abstract | Full Text (HTML/PDF) |
news and views
Unfolding the toxicity of cholesterol
Kezhong Zhang and Randal J. Kaufman
Nature Cell Biology 5, 769–770
(September 2003); doi:10.1038/ncb0903-769
| Full Text (HTML/PDF) |
news and views
Boosting p53 with interferon and viruses
Jan Vilcek
Nature Immunology 4, 825–826
(September 2003); doi:10.1038/ni0903-825
| Full Text (HTML/PDF) |
August
letters to nature
Suppression of CED-3-independent apoptosis by mitochondrial βNAC in Caenorhabditis elegans
Tim A. Bloss, Eric S. Witze and Joel H. Rothman
Nature 424, 1066–1071
(28 August 2003); doi:10.1038/nature01920
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news and views
The sirens' call
Valerie A. Fadok
Nature Cell Biology 5, 697–699
(August 2003); doi:10.1038/ncb0803-697
| Full Text (HTML/PDF) |
article
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
Andrew R. Hallahan, Joel I. Pritchard, Roshantha A. S. Chandraratna, Richard G. Ellenbogen, J. Russel Geyer, Ryan P. Overland, Andrew D. Strand, Stephen J. Tapscott and James M. Olson
Nature Medicine 9, 1033–1038
(August 2003); doi:10.1038/nm904
| Abstract | Full Text (HTML/PDF) |
review article
The biochemistry of neuronal necrosis: rogue biology?
Popi Syntichaki and Nektarios Tavernarakis
Nature Reviews Neuroscience 4, 672–684
(August 2003); doi:10.1038/nrn1174
| Abstract | Full Text (HTML / PDF) |
letters to nature
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Nika N. Danial, Colette F. Gramm, Luca Scorrano, Chen-Yu Zhang, Stefan Krauss, Ann M. Ranger, Sandeep Robert Datta, Michael E. Greenberg, Lawrence J. Licklider, Bradford B. Lowell, Steven P. Gygi and Stanley J. Korsmeyer
Nature 424, 952–956
(21 August 2003); doi:10.1038/nature01825
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news and views
Cell biology: Metabolism meets death
Julian Downward
Nature 424, 896–897
(21 August 2003); doi:10.1038/424896a
| Full Text (HTML / PDF) |
review article
PEDF: a multifaceted neurotrophic factor
Joyce Tombran-Tink and Colin J. Barnstable
Nature Reviews Neuroscience 4, 628–636
(August 2003); doi:10.1038/nrn1176
| Abstract | Full Text (HTML / PDF) |
brief communication
Cell signalling (communication arising): Cell survival and a Gadd45-factor deficiency
Arshad Amanullah, Naiyer Azam, Arthur Balliet, Christine Hollander, Barbara Hoffman, Albert Fornace Jr and Dan Liebermann
Nature 424, 741
(14 August 2003); doi:10.1038/424741b
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letter
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
Mauricio J. Reginato, Kenna R. Mills, Jessica K. Paulus, Danielle K. Lynch, Dennis C. Sgroi, Jayanta Debnath, Senthil K. Muthuswamy and Joan S. Brugge
Nature Cell Biology 5, 733–740
(August 2003); doi:10.1038/ncb1026
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article
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Gustav Mattiasson, Mehrdad Shamloo, Gunilla Gido, Kavitha Mathi, Gregor Tomasevic, Saili Yi, Craig H. Warden, Roger F. Castilho, Thorsten Melcher, Mirella Gonzalez-Zulueta, Karoly Nikolich and Tadeusz Wieloch
Nature Medicine 9, 1062–1068
(August 2003); doi:10.1038/nm903
| Abstract | Full Text (HTML/PDF) |
letter
Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools
Takashi Kimura, Satoshi Takeda, Yoji Sagiya, Mitsukazu Gotoh, Yusuke Nakamura and Hirofumi Arakawa
Nature Genetics 34, 440–445
(August 2003); doi:10.1038/ng1212
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article
Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence
Akinori Takaoka, Sumio Hayakawa, Hideyuki Yanai, Dagmar Stoiber, Hideo Negishi, Hideaki Kikuchi, Shigeru Sasaki, Kohzoh Imai, Tsukasa Shibue, Kenya Honda and Tadatsugu Taniguchi
Nature 424, 516–523
(31 July 2003); doi:10.1038/nature01850
| Abstract | Full Text (HTML / PDF) |
July
letter
Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice
Norbert M. Wikonkal, Eva Remenyik, Dejan Knezevic, Wengeng Zhang, Ming Liu, Hongyu Zhao, T. R. Berton, David G. Johnson and Douglas E. Brash
Nature Cell Biology 5, 655–660
(July 2003); doi:10.1038/ncb1001
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news and views
The yin and yang of E2F-1: balancing life and death
Nicholas B. La Thangue
Nature Cell Biology 5, 587–589
(July 2003); doi:10.1038/ncb0703-587
| Full Text (HTML/PDF) |
letter
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
Lindsey A. Allan, Nick Morrice, Suzanne Brady, Gareth Magee, Shalini Pathak and Paul R. Clarke
Nature Cell Biology 5, 647–654
(July 2003); doi:10.1038/ncb1005
| First Paragraph | Full Text (HTML/PDF) |
review article
Regulation of cell death: the calcium-apoptosis link
Sten Orrenius, Boris Zhivotovsky and Pierluigi Nicotera
Nature Reviews Molecular Cell Biology 4, 552–565
(July 2003); doi:10.1038/nrm1150
| Summary | Full Text (HTML / PDF) |
June
letter
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
Natalia Pediconi, Alessandra Ianari, Antonio Costanzo, Laura Belloni, Rita Gallo, Letizia Cimino, Antonio Porcellini, Isabella Screpanti, Clara Balsano, Edoardo Alesse, Alberto Gulino and Massimo Levrero
Nature Cell Biology 5, 552–558
(June 2003); doi:10.1038/ncb998
| First Paragraph | Full Text (HTML/PDF) |
May
review article
Caspase-independent cell death in T lymphocytes
Marja Jäättelä and Jürg Tschopp
Nature Immunology 4, 416–423
(May 2003); doi:10.1038/ni0503-416
| Abstract | Full Text (HTML/PDF) |
letter
Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
Ping Chen, Frederique Zindy, Caroline Abdala, Feng Liu, Xiankui Li, Martine F. Roussel and Neil Segil
Nature Cell Biology 5, 422–426
(May 2003); doi:10.1038/ncb976
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news and views
Deafening cycle
Bridget Baumgartner and J. Wade Harper
Nature Cell Biology 5, 385–387
(May 2003); doi:10.1038/ncb0503-385
| Full Text (HTML/PDF) |
letter
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
Mark Ditzel, Rebecca Wilson, Tencho Tenev, Anna Zachariou, Angela Paul, Emma Deas and Pascal Meier
Nature Cell Biology 5, 467–473
(May 2003); doi:10.1038/ncb984
| First Paragraph | Full Text (HTML/PDF) |
news and views
The N-end rule and regulation of apoptosis
Alexander Varshavsky
Nature Cell Biology 5, 373–376
(May 2003); doi:10.1038/ncb0503-373
| Full Text (HTML/PDF) |
review article
Apoptosis in the development and maintenance of the immune system
Joseph T. Opferman and Stanley J. Korsmeyer
Nature Immunology 4, 410–415
(May 2003); doi:10.1038/ni0503-410
| Abstract | Full Text (HTML/PDF) |
review article
Apoptosis as an HIV strategy to escape immune attack
Marie-Lise Gougeon
Nature Reviews Immunology 3, 392–404
(May 2003); doi:10.1038/nri1087
| Summary | Full Text (HTML / PDF) |
article
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
Julie Lessard and Guy Sauvageau
Nature 423, 255–260
(15 May 2003); doi:10.1038/nature01572
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letters to nature
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
In-kyung Park, Dalong Qian, Mark Kiel, Michael W. Becker, Michael Pihalja, Irving L. Weissman, Sean J. Morrison and Michael F. Clarke
Nature 423, 302–305
(15 May 2003); doi:10.1038/nature01587
| First Paragraph | Full Text (HTML / PDF) |
news and views
Stem cells: Self-renewal writ in blood
John E. Dick
Nature 423, 231–233
(15 May 2003); doi:10.1038/423231a
| Full Text (HTML / PDF) |
review article
The death effector domain protein family: regulators of cellular homeostasis
Michael D. Tibbetts, Lixin Zheng and Michael J. Lenardo
Nature Immunology 4, 404–409
(May 2003); doi:10.1038/ni0503-404
| Abstract | Full Text (HTML/PDF) |
review article
Negative selection — clearing out the bad apples from the T-cell repertoire
Ed Palmer
Nature Reviews Immunology 3, 383–391
(May 2003); doi:10.1038/nri1085
| Summary | Full Text (HTML / PDF) |
review article
Mechanisms, challenges and opportunities in stroke
Eng H. Lo, Turgay Dalkara and Michael A. Moskowitz
Nature Reviews Neuroscience 4, 399–414
(May 2003); doi:10.1038/nrn1106
| Summary | Full Text (HTML / PDF) |
review article
NODs: intracellular proteins involved in inflammation and apoptosis
Naohiro Inohara and Gabriel Nuñez
Nature Reviews Immunology 3, 371–382
(May 2003); doi:10.1038/nri1086
| Summary | Full Text (HTML / PDF) |
review article
Cell death and immunity: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
Judy Lieberman
Nature Reviews Immunology 3, 361–370
(May 2003); doi:10.1038/nri1083
| Summary | Full Text (HTML / PDF) |
review article
Cancer and ageing: rival demons?
Judith Campisi
Nature Reviews Cancer 3, 339–349
(May 2003); doi:10.1038/nrc1073
| Summary | Full Text (HTML / PDF) |
review article
Targeting programmed cell death in neurodegenerative diseases
Miquel Vila & Serge Przedborski
Nature Reviews Neuroscience 4, 365–375
(May 2003); doi:10.1038/nrn1100
| Summary | Full Text (HTML / PDF) |
research article
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
Eric C. Hsu, Belinda Hsi, Masami Hirota-Tsuchihara, Jurgen Ruland, Cathy Iorio, Farida Sarangi, Jingyu Diao, Giovanni Migliaccio, D. Lorne Tyrrell, Norman Kneteman and Christopher D. Richardson
Nature Biotechnology 21, 519–525
(May 2003); doi:10.1038/nbt817
| Abstract | Full Text (HTML/PDF) |
April
article
Ku70 suppresses the apoptotic translocation of Bax to mitochondria
Motoshi Sawada, Weiyong Sun, Paulette Hayes, Konstantin Leskov, David A. Boothman and Shigemi Matsuyama
Nature Cell Biology 5, 320–329
(April 2003); doi:10.1038/ncb950
| Abstract | Full Text (HTML/PDF) |
letter
Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70
Motoshi Sawada, Paulette Hayes and Shigemi Matsuyama
Nature Cell Biology 5, 352–357
(April 2003); doi:10.1038/ncb955
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news and views
A retention factor keeps death at bay
Steven F. Nothwehr and Jean-Claude Martinou
Nature Cell Biology 5, 281–283
(April 2003); doi:10.1038/ncb0403-281
| Full Text (HTML/PDF) |
letters to nature
PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
Yuxin Yin, Yu-Xin Liu, Yan J. Jin, Eric J. Hall and J. Carl Barrett
Nature 422, 527–531
(03 April 2003); doi:10.1038/nature01519
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article
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
Anje Cauwels, Ben Janssen, Anouk Waeytens, Claude Cuvelier and Peter Brouckaert
Nature Immunology 4, 387–393
(April 2003); doi:10.1038/ni914
| Abstract | Full Text (HTML/PDF) |
news and views
Caspase activation is not death
Jean-Luc Perfettini and Guido Kroemer
Nature Immunology 4, 308–310
(April 2003); doi:10.1038/ni0403-308
| Full Text (HTML/PDF) |
review article
Senescence, apoptosis and therapy — cutting the lifelines of cancer
Clemens A. Schmitt
Nature Reviews Cancer 3, 286–295
(April 2003); doi:10.1038/nrc1044
| Summary | Full Text (HTML / PDF) |
review
Tumor necrosis factor signaling
H Wajant, K Pfizenmaier and P Scheurich
Cell Death and Differentiation 10, 45–65
(January 2003); doi:10.1038/sj.cdd.4401189
| Abstract |
review
Apo2L/TRAIL and its death and decoy receptors
H N LeBlanc and A Ashkenazi
Cell Death and Differentiation 10, 66–75
(January 2003); doi:10.1038/sj.cdd.4401187
| Abstract |
March
research article
In situ assembly of enzyme inhibitors using extended tethering
Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann, Tinh N. Luong, Robert L. Simmons, Warren L. DeLano, Ingrid C. Choong, Matthew T. Burdett, W. Michael Flanagan, Dennis Lee, Eric M. Gordon and Tom O'Brien
Nature Biotechnology 21, 308–314
(March 2003); doi:10.1038/nbt786
| Abstract | Full Text (HTML/PDF) |
letter
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Enid R. Neptune, Pamela A. Frischmeyer, Dan E. Arking, Loretha Myers, Tracie E. Bunton, Barbara Gayraud, Francesco Ramirez, Lynn Y. Sakai and Harry C. Dietz
Nature Genetics 33, 407–411
(March 2003); doi:10.1038/ng1116
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news and views
Fibrillin controls TGF-β activation
Vesa Kaartinen and David Warburton
Nature Genetics 33, 331–332
(March 2003); doi:10.1038/ng0303-331
| Full Text (HTML/PDF) |
letter
p53RDL1 regulates p53-dependent apoptosis
Chizu Tanikawa, Koichi Matsuda, Seisuke Fukuda, Yusuke Nakamura and Hirofumi Arakawa
Nature Cell Biology 5, 216–223
(March 2003); doi:10.1038/ncb943
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article
Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice
Salah-Eddine Lamhamedi-Cherradi, Shi-Jun Zheng, Kimberly A. Maguschak, Jacques Peschon and Youhai H. Chen
Nature Immunology 4, 255–260
(March 2003); doi:10.1038/ni894
| Abstract | Full Text (HTML/PDF) |
news and views
The suicide in the thymus, a twisted trail
Douglas R. Green
Nature Immunology 4, 207–208
(March 2003); doi:10.1038/ni0303-207
| Full Text (HTML/PDF) |
article
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
Tong Cheng, Dong Liu, John H. Griffin, José A. Fernández, Francis Castellino, Elliot D. Rosen, Kenji Fukudome and Berislav V. Zlokovic
Nature Medicine 9, 338–342
(March 2003); doi:10.1038/nm826
| Abstract | Full Text (HTML/PDF) |
news and views
PAR1 signaling: more good than harm?
Wolfram Ruf
Nature Medicine 9, 258–260
(March 2003); doi:10.1038/nm0303-258
| Full Text (HTML/PDF) |
article
RNA interference targeting Fas protects mice from fulminant hepatitis
Erwei Song, Sang-Kyung Lee, Jie Wang, Nedim Ince, Nengtai Ouyang, Jun Min, Jisheng Chen, Premlata Shankar and Judy Lieberman
Nature Medicine 9, 347–351
(March 2003); doi:10.1038/nm828
| Abstract | Full Text (HTML/PDF) |
news and views
siRNAs knock down hepatitis
Phillip D. Zamore and Neil Aronin
Nature Medicine 9, 266–267
(March 2003); doi:10.1038/nm0303-266
| Full Text (HTML/PDF) |
article
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
Patrick Dumont, J. I-Ju Leu, Anthony C. Della Pietra, III Donna L. George and Maureen Murphy
Nature Genetics 33, 357–365
(March 2003); doi:10.1038/ng1093
| Abstract | Full Text (HTML/PDF) |
February
article
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
Zusen Fan, Paul J. Beresford, Dong Zhang, Zhan Xu, Carl D. Novina, Akira Yoshida, Yves Pommier and Judy Lieberman
Nature Immunology 4, 145–153
(February 2003); doi:10.1038/ni885
| Abstract | Full Text (HTML/PDF) |
news and views
Granzyme A: the road less traveled
Michael J. Pinkoski and Douglas R. Green
Nature Immunology 4, 106–108
(February 2003); doi:10.1038/ni0203-106
| Full Text (HTML/PDF) |
review article
The role of p53 in determining sensitivity to radiotherapy
Andrei V. Gudkov and Elena A. Komarova
Nature Reviews Cancer 3, 117–129
(February 2003); doi:10.1038/nrc992
| Summary | Full Text (HTML / PDF) |
letter
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi, Yardena Samuels, Nigel J. O'Neil, Giuseppe Trigiante, Tim Crook, Jung-Kuang Hsieh, Daniel J. O'Connor, Shan Zhong, Isabelle Campargue, Matthew L. Tomlinson, Patricia E. Kuwabara and Xin Lu
Nature Genetics 33, 162–167
(February 2003); doi:10.1038/ng1070
| First Paragraph | Full Text (HTML/PDF) |
news and views
Mitochondria, AIF and caspases — rivaling for cell death execution
Josef M. Penninger and Guido Kroemer
Nature Cell Biology 5, 97–99
(February 2003); doi:10.1038/ncb0203-97
| Full Text (HTML/PDF) |
review article
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
B. Matija Peterlin and Didier Trono
Nature Reviews Immunology 3, 97–107
(February 2003); doi:10.1038/nri998
| Summary | Full Text (HTML / PDF) |
review article
Inhibiting the p53-MDM2 interaction: an important target for cancer therapy
Patrick Chène
Nature Reviews Cancer 3, 102–109
(February 2003); doi:10.1038/nrc991
| Summary | Full Text (HTML / PDF) |
review article
Coordinated regulation of life and death by RB
B. Nelson Chau and Jean Y.J. Wang
Nature Reviews Cancer 3, 130–138
(February 2003); doi:10.1038/nrc993
| Summary | Full Text (HTML / PDF) |
article
Fas engagement induces neurite growth through ERK activation and p35 upregulation
Julie Desbarats, Raymond B. Birge, Manuelle Mimouni-Rongy, David E. Weinstein, Jean-Sébastien Palerme and M. Karen Newell
Nature Cell Biology 5, 118–125
(February 2003); doi:10.1038/ncb916
| Abstract | Full Text (HTML/PDF) |
news and views
Killer wiles: growing interest in Fas
Brigitte Pettmann and Christopher E. Henderson
Nature Cell Biology 5, 91–92
(February 2003); doi:10.1038/ncb0203-91
| Full Text (HTML/PDF) |
original paper
Bcl-xL and Akt cooperate to promote leukemogenesis in vivo
Robyn Karnauskas, Qun Niu, Sunit Talapatra, David R. Plas, Marianne E. Greene, John D. Crispino and Charles M. Rudin
Oncogene 22, 688–698
(6 February 2003); doi:10.1038/sj.onc.1206159
| Abstract |
January
original paper
H-Ras-specific activation of NF-κB protects NIH 3T3 cells against stimulus-dependent apoptosis
Olga Millán, Alicia Ballester, Antonio Castrillo, José Luis de la Oliva, Paqui G Través, José María Rojas and Lisardo Boscá
Oncogene 22, 477–483
(30 January 2003); doi:10.1038/sj.onc.1206179
| Abstract |
review article
Validating survivin as a cancer therapeutic target
Dario C. Altieri
Nature Reviews Cancer 3, 46–54
(January 2003); doi:10.1038/nrc968
| Summary | Full Text (HTML / PDF) |
article
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
Michiko Shirane and Keiichi I. Nakayama
Nature Cell Biology 5, 28–37
(January 2003); doi:10.1038/ncb894
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Defying death: showing Bcl-2 the way home
Colin Adrain, Emma M. Creagh and Seamus J. Martin
Nature Cell Biology 5, 9–11
(January 2003); doi:10.1038/ncb0103-9a
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Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells
Howard A. Anderson, Caroline A. Maylock, Joy A. Williams, Cloud P. Paweletz, Hongjun Shu and Emily Shacter
Nature Immunology 4, 87–91
(January 2003); doi:10.1038/ni871
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Hepatic T cells and liver tolerance
Ian Nicholas Crispe
Nature Reviews Immunology 3, 51–62
(January 2003); doi:10.1038/nri981
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