Research library: Apoptosis
2004: December
| November
| October
| September
| August
| July
| June
| May
| April
| March
| February
| January
Other Years: 2002 | 2003 | 2005 | 2006 | 2007 | 2008
December
article
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
Natalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G G C Verhoef, Maria Masucci, Aladdin Pramanik and Galina Selivanova
Nature Medicine 10, 1321–1328
(December 2004); doi:10.1038/nm1146
| Abstract | Full Text (HTML/PDF) |
news and views
Cancer drug discovery: the wisdom of imprecision
Andrei V Gudkov
Nature Medicine 10, 1298–1299
(December 2004); doi:10.1038/nm1204-1298
| Full Text (HTML/PDF) |
letter
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C
Dong Liu, Tong Cheng, Huang Guo, José A Fernández, John H Griffin, Xiaomei Song and Berislav V Zlokovic
Nature Medicine 10, 1379–1383
(December 2004); doi:10.1038/nm1122
| First Paragraph | Full Text (HTML/PDF) |
news and views
Combination stroke therapy: easy as APC?
Eng H Lo
Nature Medicine 10, 1295–1296
(December 2004); doi:10.1038/nm1204-1295
| Full Text (HTML/PDF) |
review article
The role of the unfolded protein response in tumour development: friend or foe?
Yanjun Ma and Linda M. Hendershot
Nature Reviews Cancer 4, 966–977
(December 2004); doi:10.1038/nrc1505
| Summary | Full Text (HTML / PDF) |
review article
Netrin-1 and its receptors in tumorigenesis
Hirofumi Arakawa
Nature Reviews Cancer 4, 978–987
(December 2004); doi:10.1038/nrc1504
| Summary | Full Text (HTML / PDF) |
review article
The genetics of cell death: approaches, insights and opportunities in Drosophila
Bruce A. Hay, Jun R. Huh and Ming Guo
Nature Reviews Genetics 5, 911–922
(December 2004); doi:10.1038/nrg1491
| Summary | Full Text (HTML / PDF) |
November
article
Regulation of p53 activity through lysine methylation
Sergei Chuikov, Julia K. Kurash, Jonathan R. Wilson, Bing Xiao, Neil Justin, Gleb S. Ivanov, Kristine McKinney, Paul Tempst, Carol Prives, Steven J. Gamblin, Nickolai A. Barlev and Danny Reinberg
Nature 432, 353–360
(18 November 2004); doi:10.1038/nature03117
| Abstract | Full Text (HTML / PDF) |
review article
Molecular mechanisms of caspase regulation during apoptosis
Stefan J. Riedl and Yigong Shi
Nature Reviews Molecular Cell Biology 5, 897–907
(November 2004); doi:10.1038/nrm1496
| Abstract | Full Text (HTML / PDF) |
letter
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
Kwai Wa Cheng, John P Lahad, Wen-lin Kuo, Anna Lapuk, Kyosuke Yamada, Nelly Auersperg, Jinsong Liu, Karen Smith-McCune, Karen H Lu, David Fishman, Joe W Gray and Gordon B Mills
Nature Medicine 10, 1251–1256
(November 2004); doi:10.1038/nm1125
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
Andrzej Ptasznik, Yuji Nakata, Anna Kalota, Stephen G Emerson and Alan M. Gewirtz
Nature Medicine 10, 1187–1189
(November 2004); doi:10.1038/nm1127
| First Paragraph | Full Text (HTML/PDF) |
October
review article
The multifaceted roles of TRAFs in the regulation of B-cell function
Gail A. Bishop
Nature Reviews Immunology 4, 775–786
(October 2004); doi:10.1038/nri1462
| Abstract | Full Text (HTML / PDF) |
letters to nature
Hedgehog signalling controls eye degeneration in blind cavefish
Yoshiyuki Yamamoto, David W. Stock and William R. Jeffery
Nature 431, 844–847
(14 October 2004); doi:10.1038/nature02864
| First Paragraph | Full Text (HTML / PDF) |
review article
Connecting proliferation and apoptosis in development and disease
David R. Hipfner and Stephen M. Cohen
Nature Reviews Molecular Cell Biology 5, 805–815
(October 2004); doi:10.1038/nrm1491
| Abstract | Full Text (HTML / PDF) |
review article
Chlamydia and apoptosis: life and death decisions of an intracellular pathogen
Gerald I. Byrne and David M. Ojcius
Nature Reviews Microbiology 2, 802–808
(October 2004); doi:10.1038/nrmicro1007
| Abstract | Full Text (HTML/PDF) |
letters to nature
p19ARF directly and differentially controls the functions of c-Myc independently of p53
Ying Qi, Mark A. Gregory, Zhaoliang Li, Jeffrey P. Brousal, Kimberly West and Stephen R. Hann
Nature 431, 712–717
(07 October 2004); doi:10.1038/nature02958
| First Paragraph | Full Text (HTML / PDF) |
September
article
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
Yanyan Hao, Keiko Sekine, Atsushi Kawabata, Hitoshi Nakamura, Toshiyasu Ishioka, Hirokazu Ohata, Ryohei Katayama, Chizuko Hashimoto, Xiaodong Zhang, Tetsuo Noda, Takashi Tsuruo and Mikihiko Naito
Nature Cell Biology 6, 849–860
(September 2004); doi:10.1038/ncb1159
| Abstract | Full Text (HTML/PDF) |
news and views
An Apollon vista of death and destruction
Seamus J. Martin
Nature Cell Biology 6, 804–806
(September 2004); doi:10.1038/ncb0904-804
| Full Text (HTML/PDF) |
news and views
Maiming mitochondria in familial ALS
Valina L Dawson
Nature Medicine 10, 905–906
(September 2004); doi:10.1038/nm0904-905
| Full Text (HTML/PDF) |
article
Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
Fazilat F Mohammed, David S Smookler, Suzanne E M Taylor, Barbara Fingleton, Zamaneh Kassiri, Otto H Sanchez, Jane L English, Lynn M Matrisian, Billie Au, Wen-Chen Yeh and Rama Khokha
Nature Genetics 36, 969–977
(September 2004); doi:10.1038/ng1413
| Abstract | Full Text (HTML/PDF) |
news and views
TIMP3 checks inflammation
Roy A Black
Nature Genetics 36, 934–935
(September 2004); doi:10.1038/ng0904-934
| Full Text (HTML/PDF) |
review article
Adult neuron survival strategies — slamming on the brakes
Susanna C. Benn and Clifford J. Woolf
Nature Reviews Neuroscience 5, 686–700
(September 2004); doi:10.1038/nrn1477
| Abstract | Full Text (HTML / PDF) |
review article
Cell signalling and the control of pre-mRNA splicing
Chanseok Shin and James L. Manley
Nature Reviews Molecular Cell Biology 5, 727–738
(September 2004); doi:10.1038/nrm1467
| Abstract | Full Text (HTML / PDF) |
letters to nature
Netrin–1 controls colorectal tumorigenesis by regulating apoptosis
Laetitia Mazelin, Agnès Bernet, Christelle Bonod–Bidaud, Laurent Pays, Ségolène Arnaud, Christian Gespach, Dale E Bredesen, Jean–Yves Scoazec and Patrick Mehlen
Nature 431, 80–84
(02 September 2004); doi:10.1038/nature02788
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Cell survival guide
Eric R. Fearon and Kathleen R. Cho
Nature 431, 35–36
(02 September 2004); doi:10.1038/431035a
| Full Text (HTML / PDF) |
review article
Apoptosis and genomic instability
Boris Zhivotovsky and Guido Kroemer
Nature Reviews Molecular Cell Biology 5, 752–762
(September 2004); doi:10.1038/nrm1443
| Summary | Full Text (HTML / PDF) |
August
review article
Pathways of apoptotic and non-apoptotic death in tumour cells
Hitoshi Okada and Tak W. Mak
Nature Reviews Cancer 4, 592–603
(August 2004); doi:10.1038/nrc1412
| Summary | Full Text (HTML / PDF) |
July
letter
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
Rosa Bernardi, Pier Paolo Scaglioni, Stephan Bergmann, Henning F. Horn, Karen H. Vousden and Pier Paolo Pandolfi
Nature Cell Biology 6, 665–672
(July 2004); doi:10.1038/ncb1147
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Sanjeev Mariathasan, Kim Newton, Denise M. Monack, Domagoj Vucic, Dorothy M. French, Wyne P. Lee, Meron Roose-Girma, Sharon Erickson and Vishva M. Dixit
Nature 430, 213–218
(08 July 2004); doi:10.1038/nature02664
| First Paragraph | Full Text (HTML / PDF) |
June
article
A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells
Wu-Shiun Hou and Luk Van Parijs
Nature Immunology 5, 583–589
(June 2004); doi:10.1038/ni1071
| Abstract | Full Text (HTML/PDF) |
news and views
Balancing life and death
Muriel Moser
Nature Immunology 5, 559–560
(June 2004); doi:10.1038/ni0604-559
| Full Text (HTML/PDF) |
article
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice
Sören T Eichhorst, Andreas Krueger, Susanne Müerköster, Stefanie C Fas, Alexander Golks, Uwe Gruetzner, Louise Schubert, Christine Opelz, Manfred Bilzer, Alexander L Gerbes and Peter H Krammer
Nature Medicine 10, 602–609
(June 2004); doi:10.1038/nm1049
| Abstract | Full Text (HTML/PDF) |
news and views
Cheating death in the liver
M Eugenia Guicciardi and Gregory J Gores
Nature Medicine 10, 587–588
(June 2004); doi:10.1038/nm0604-587
| Full Text (HTML/PDF) |
news and views
Cutting into innate immunity
Astar Winoto
Nature Immunology 5, 563–564
(June 2004); doi:10.1038/ni0604-563
| Full Text (HTML/PDF) |
May
news and views
A Bit-role for integrins in apoptosis
Dwayne G. Stupack and David A. Cheresh
Nature Cell Biology 6, 388–389
(May 2004); doi:10.1038/ncb0504-388
| Full Text (HTML/PDF) |
brief communication
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Paola Londei, Carlos Cordon-Cardo and Pier Paolo Pandolfi
Nature Medicine 10, 484–486
(May 2004); doi:10.1038/nm1042
| First Paragraph | Full Text (HTML/PDF) |
article
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim
Nieng Yan, Jia-Wei Wu, Jijie Chai, Wenyu Li and Yigong Shi
Nature Structural and Molecular Biology 11, 420–428
(May 2004); doi:10.1038/nsmb764
| Abstract | Full Text (HTML/PDF) |
news and views
A fine balance for life and death decisions
Barbara A Schreader and John R Nambu
Nature Structural and Molecular Biology 11, 386–388
(May 2004); doi:10.1038/nsmb0504-386
| Full Text (HTML/PDF) |
letter
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
J. I-Ju Leu, Patrick Dumont, Michael Hafey, Maureen E. Murphy and Donna L. George
Nature Cell Biology 6, 443–450
(May 2004); doi:10.1038/ncb1123
| First Paragraph | Full Text (HTML/PDF) |
news and views
Fatal liaisons of p53 with Bax and Bak
Jean-Luc Perfettini, Romano T. Kroemer and Guido Kroemer
Nature Cell Biology 6, 386–388
(May 2004); doi:10.1038/ncb0504-386
| Full Text (HTML/PDF) |
letters to nature
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
Maya Saleh, John P. Vaillancourt, Rona K. Graham, Matthew Huyck, Srinivasa M. Srinivasula, Emad S. Alnemri, Martin H. Steinberg, Vikki Nolan, Clinton T. Baldwin, Richard S. Hotchkiss, Timothy G. Buchman, Barbara A. Zehnbauer, Michael R. Hayden, Lindsay A. Farrer, Sophie Roy and Donald W. Nicholson
Nature 429, 75–79
(06 May 2004); doi:10.1038/nature02451
| First Paragraph | Full Text (HTML / PDF) |
news and views
Human genetics: An inflammatory issue
Kevin J. Tracey and H. Shaw Warren
Nature 429, 35–37
(06 May 2004); doi:10.1038/429035a
| Full Text (HTML / PDF) |
April
letter
Human lupus T cells resist inactivation and escape death by upregulating COX-2
Luting Xu, Li Zhang, Yajun Yi, Hee-Kap Kang and Syamal K Datta
Nature Medicine 10, 411–415
(April 2004); doi:10.1038/nm1005
| First Paragraph | Full Text (HTML/PDF) |
review article
Plant cell biology: Controlled cell death, plant survival and development
Eric Lam
Nature Reviews Molecular Cell Biology 5, 305–315
(April 2004); doi:10.1038/nrm1358
| Abstract | Full Text (HTML / PDF) |
letter
PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3
Ingrid Remy, Annie Montmarquette and Stephen W. Michnick
Nature Cell Biology 6, 358–365
(April 2004); doi:10.1038/ncb1113
| First Paragraph | Full Text (HTML/PDF) |
letter
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Andrew R. Conery, Yanna Cao, E. Aubrey Thompson, Courtney M. Townsend, Jr Tien C. Ko and Kunxin Luo
Nature Cell Biology 6, 366–372
(April 2004); doi:10.1038/ncb1117
| First Paragraph | Full Text (HTML/PDF) |
news and views
Cancer's sphere of influence
Charlotte Schubert
Nature Medicine 10, 349
(April 2004); doi:10.1038/nm0404-349
| Full Text (HTML/PDF) |
March
letters to nature
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
Hans-Guido Wendel, Elisa de Stanchina, Jordan S. Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier and Scott W. Lowe
Nature 428, 332–337
(18 March 2004); doi:10.1038/nature02369
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Survival pathways meet their end
Frank McCormick
Nature 428, 267–269
(18 March 2004); doi:10.1038/428267a
| Full Text (HTML / PDF) |
letters to nature
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J. Kaufman, Lars Eckmann, Donald G. Guiney and Michael Karin
Nature 428, 341–345
(18 March 2004); doi:10.1038/nature02405
| First Paragraph | Full Text (HTML / PDF) |
article
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Elizabeth A Harrington, David Bebbington, Jeff Moore, Richele K Rasmussen, Abi O Ajose-Adeogun, Tomoko Nakayama, Joanne A Graham, Cecile Demur, Thierry Hercend, Anita Diu-Hercend, Michael Su, Julian M C Golec and Karen M Miller
Nature Medicine 10, 262–267
(March 2004); doi:10.1038/nm1003
| Abstract | Full Text (HTML/PDF) |
news and views
Aurora kinases dawn as cancer drug targets
Edward A Sausville
Nature Medicine 10, 234–235
(March 2004); doi:10.1038/nm0304-234
| Full Text (HTML/PDF) |
perspectives
Opinion: Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
Matthew L. Albert
Nature Reviews Immunology 4, 223–231
(March 2004); doi:10.1038/nri1308
| Abstract | Full Text (HTML / PDF) |
February
letters to nature
Sortilin is essential for proNGF-induced neuronal cell death
Anders Nykjaer, Ramee Lee, Kenneth K. Teng, Pernille Jansen, Peder Madsen, Morten S. Nielsen, Christian Jacobsen, Marco Kliemannel, Elisabeth Schwarz, Thomas E. Willnow, Barbara L. Hempstead and Claus M. Petersen
Nature 427, 843–848
(26 February 2004); doi:10.1038/nature02319
| First Paragraph | Full Text (HTML / PDF) |
news and views
Neurobiology: A move to sort life from death
David R. Kaplan and Freda D. Miller
Nature 427, 798–799
(26 February 2004); doi:10.1038/427798a
| Full Text (HTML / PDF) |
letter
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
Takao Ohtsuka, Hoon Ryu, Yohji A. Minamishima, Salvador Macip, Junji Sagara, Keiichi I. Nakayama, Stuart A. Aaronson and Sam W. Lee
Nature Cell Biology 6, 121–128
(February 2004); doi:10.1038/ncb1087
| First Paragraph | Full Text (HTML/PDF) |
letter
Gadd45β mediates the NF-kB suppression of JNK signalling by targeting MKK7/JNKK2
Salvatore Papa, Francesca Zazzeroni, Concetta Bubici, Shanthi Jayawardena, Kellean Alvarez, Shuji Matsuda, Dung U. Nguyen, Can G. Pham, Andreas H. Nelsbach, Tiziana Melis, Enrico De Smaele, Wei-Jen Tang, Luciano D'Adamio and Guido Franzoso
Nature Cell Biology 6, 146–153
(February 2004); doi:10.1038/ncb1093
| First Paragraph | Full Text (HTML/PDF) |
article
The costimulation-regulated duration of PKB activation controls T cell longevity
Jianxun Song, Shahram Salek-Ardakani, Paul R Rogers, Mary Cheng, Luk Van Parijs and Michael Croft
Nature Immunology 5, 150–158
(February 2004); doi:10.1038/ni1030
| Abstract | Full Text (HTML/PDF) |
article
Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death
Jagan R Muppidi and Richard M Siegel
Nature Immunology 5, 182–189
(February 2004); doi:10.1038/ni1024
| Abstract | Full Text (HTML/PDF) |
news and views
Right place, right time
Christopher J Froelich
Nature Immunology 5, 124–125
(February 2004); doi:10.1038/ni0204-124
| Full Text (HTML/PDF) |
January
letters to nature
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
Jason E. Kokoszka , Katrina G. Waymire, Shawn E. Levy, James E. Sligh, Jiyang Cai, Dean P. Jones, Grant R. MacGregor and Douglas C. Wallace
Nature 427, 461–465
(29 January 2004); doi:10.1038/nature02229
| First Paragraph | Full Text (HTML / PDF) |
letter
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
Geng Liu, John M Parant, Gene Lang, Patty Chau, Arturo Chavez-Reyes, Adel K El-Naggar, Asha Multani, Sandy Chang and Guillermina Lozano
Nature Genetics 36, 63–68
(January 2004); doi:10.1038/ng1282
| First Paragraph | Full Text (HTML/PDF) |
news and views
Conquering the complexity of p53
Laura D Attardi and Ronald A DePinho
Nature Genetics 36, 7–8
(January 2004); doi:10.1038/ng0104-7
| Full Text (HTML/PDF) |
|
