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Research library: Apoptosis

2007: December | November | October | September | August | May | March | February | January

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article
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
Pushpa Pandiyan, Lixin Zheng, Satoru Ishihara, Jennifer Reed & Michael J Lenardo
Nature Immunology 8, 1353–1362
(December 2007); doi:10.1038/ni1536
| Summary | Full Text (HTML / PDF) |

news and views
Competition for cytokines: Treg cells take all
Alexander Scheffold, Kenneth M Murphy & Thomas Höfer
Nature Immunology 8, 1285–1287
(December 2007); doi:10.1038/ni1207-1285
| Full Text (HTML / PDF) |

review
Engulfment of apoptotic cells: signals for a good meal
Kodi S. Ravichandran & Ulrike Lorenz
Nature Reviews Immunology 7, 964–974
(December 2007); doi:10.1038/nri2214
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article
Pim-1 regulates cardiomyocyte survival downstream of Akt
John A Muraski et al.
Nature Medicine 13, 1467–1475
(December 2007); doi:10.1038/nm1671
| Summary | Full Text (HTML / PDF) |

letter
AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10
Ho-June Lee et al.
Nature Cell Biology 9, 1303–1310
(November 2007); doi:10.1038/ncb1650
| Summary | Full Text (HTML / PDF) |

letter
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
Massimo M Santoro, Temesgen Samuel, Tracy Mitchell, John C Reed & Didier Y R Stainier
Nature Genetics 39, 1397–1402
(November 2007); doi:10.1038/ng.2007.8
| Summary | Full Text (HTML / PDF) |

news and views
Building in resistance to endothelial cell death
Massimiliano Mazzone, Carmen Ruiz de Almodovar & Peter Carmeliet
Nature Genetics 39, 1308–1309
(November 2007); doi:10.1038/ng1107-1308
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article
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
Yonghua Yang et al.
Nature Cell Biology 9, 1253–1262
(November 2007); doi:10.1038/ncb1645
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letter
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
Julie Pinkston-Gosse & Cynthia Kenyon
Nature Genetics 39, 1403–1409
(November 2007); doi:10.1038/ng.2007.1
| Summary | Full Text (HTML / PDF) |

news and views
Aging and cancer: killing two birds with one worm
Anne Brunet
Nature Genetics 39, 1306–1307
(November 2007); doi:10.1038/ng1107-1306
| Full Text (HTML / PDF) |

article
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Pernille Jansen et al.
Nature Neuroscience 10, 1449–1457
(November 2007); doi:10.1038/nn2000
| Summary | Full Text (HTML / PDF) |

review
Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics
Pedro Jares, Dolors Colomer & Elias Campo
Nature Reviews Cancer 7, 750–762
(October 2007); doi:10.1038/nrc2230
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article
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Klaus W Wagner, Elizabeth A Punnoose, Thomas Januario, David A Lawrence, Robert M Pitti, Kate Lancaster, Dori Lee, Melissa von Goetz, Sharon Fong Yee, Klara Totpal, Ling Huw, Viswanatham Katta, Guy Cavet, Sarah G Hymowitz, Lukas Amler & Avi Ashkenazi
Nature Medicine 13, 1070–1077
(September 2007); doi:10.1038/nm1627
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article
Lack of Fas antagonism by Met in human fatty liver disease
Chunbin Zou, Jihong Ma, Xue Wang, Lida Guo, Zhenqi Zhu, John Stoops, Amanda E Eaker, Carla J Johnson, Stephen Strom, George K Michalopoulos, Marie C DeFrances & Reza Zarnegar
Nature Medicine 13, 1078–1085
(September 2007); doi:10.1038/nm1625
| Summary | Full Text (HTML / PDF) |

perspective
The biological role of death and lysis in biofilm development
Kenneth W. Bayles
Nature Reviews Microbiology 5, 721–726
(September 2007); doi:10.1038/nrmicro1743
| Summary | Full Text (HTML / PDF) |

perspective
Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
Marco Giorgio, Mirella Trinei, Enrica Migliaccio & Pier Giuseppe Pelicci
Nature Reviews Molecular Cell Biology 8, 722–728
(September 2007); doi:10.1038/nrm2240
| Summary | Full Text (HTML / PDF) |

review
Self-eating and self-killing: crosstalk between autophagy and apoptosis
M. Chiara Maiuri, Einat Zalckvar, Adi Kimchi & Guido Kroemer
Nature Reviews Molecular Cell Biology 8, 741–752
(September 2007); doi:10.1038/nrm2239
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article
MALT1 directs B cell receptor-induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit
Uta Ferch, Christian Meyer zum Büschenfelde, Andreas Gewies, Elmar Wegener, Sandra Rauser, Christian Peschel, Daniel Krappmann & Jürgen Ruland
Nature Immunology 8, 984–991
(2007); doi:10.1038/ni1493
| Summary | Full Text (HTML / PDF) |

letter
p53 is regulated by the lysine demethylase LSD1
Jing Huang, Roopsha Sengupta, Alexsandra B. Espejo, Min Gyu Lee, Jean A. Dorsey, Mario Richter, Susanne Opravil, Ramin Shiekhattar, Mark T. Bedford, Thomas Jenuwein & Shelley L. Berger
Nature 449, 105–108
(6 September 2007); doi:10.1038/nature06092
| Summary | Full Text (HTML / PDF) |

review
Filling out the Hippo pathway
Leslie J. Saucedo & Bruce A. Edgar
Nature Reviews Molecular Cell Biology 8, 613–621
(August 2007); doi:10.1038/nrm2221
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article
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
Marta A Toscano, Germán A Bianco, Juan M Ilarregui, Diego O Croci, Jorge Correale, Joseph D Hernandez, Norberto W Zwirner, Francoise Poirier, Eleanor M Riley, Linda G Baum & Gabriel A Rabinovich
Nature Immunology 8, 825–834
(August 2007); doi:10.1038/ni1482
| Summary | Full Text (HTML / PDF) |

news and views
Parkinson's disease: Pro-survival effects of PINK1
Asa Abeliovich
Nature 448, 759–760
(16 August 2007); doi:10.1038/448759a
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article
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Julie Litz, Cristina C Clement, Yanlong Kang, Yuhong She, Nian Wu, Sara Felts, Peter Wipf, Joan Massague, Xuejun Jiang, Jeffrey L Brodsky, Geoffrey W Krystal & Gabriela Chiosis
Nature Chemical Biology 3, 498–507
(August 2007); doi:10.1038/nchembio.2007.10
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news and views
Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer
Paul Workman & Marissa V Powers
Nature Chemical Biology 3, 455–457
(August 2007); doi:10.1038/nchembio0807-455
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article
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, Hyacinth Tabarias, Mariapia A Degli-Esposti, Grant Dewson, Simon N Willis, Noboru Motoyama, David C S Huang, Stephen L Nutt, David M Tarlinton & Andreas Strasser
Nature Immunology 8, 856–863
(August 2007); doi:10.1038/ni1487
| Summary | Full Text (HTML / PDF) |

letter
Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
Massimo Attanasio, N Henriette Uhlenhaut, Vitor H Sousa, John F O'Toole, Edgar Otto, Katrin Anlag, Claudia Klugmann, Anna-Corina Treier, Juliana Helou, John A Sayer, Dominik Seelow, Gudrun Nürnberg, Christian Becker, Albert E Chudley, Peter Nürnberg, Friedhelm Hildebrandt & Mathias Treier
Nature Genetics 39, 1018–1024
(August 2007); doi:10.1038/ng2072
| Summary | Full Text (HTML / PDF) |

news and views
GAPDH and the search for alternative energy
Shiwei Song & Toren Finkel
Nature Cell Biology 9, 869–870
(August 2007); doi:10.1038/ncb0807-869
| Summary | Full Text (HTML / PDF) |

letter
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
Christopher P. Baines, Robert A. Kaiser, Tatiana Sheiko, William J. Craigen & Jeffery D. Molkentin
Nature Cell Biology 9, 550–555
(May 2007); doi:10.1038/ncb1575
| Summary | Full Text (HTML / PDF) |

news and views
Mitochondrial apoptosis without VDAC
Lorenzo Galluzzi & Guido Kroemer
Nature Cell Biology 9, 487–489
(May 2007); doi:10.1038/ncb0507-487
| Summary | Full Text (HTML / PDF) |

letter
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
Travis H. Stracker, Monica Morales, Suzana S. Couto, Hussein Hussein & John H. J. Petrini
Nature 447, 218–221
(10 May 2007); doi:10.1038/nature05740
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letter
C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1
Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichuan Gu, Chun-Ling Sun, Chonglin Yang, Yong Shi, Tetsuo Kobayashi, Yigong Shi, Shohei Mitani, Xiao-Song Xie & Ding Xue
Nature Cell Biology 9, 541–549
(May 2007); doi:10.1038/ncb1574
| Summary | Full Text (HTML / PDF) |

review
The apoptosome: signalling platform of cell death
Stefan J. Riedl & Guy S. Salvesen
Nature Reviews Molecular Cell Biology 8, 405–413
(May 2007); doi:10.1038/nrm2153
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article
Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability
Minsun Park, Yeryoung Yong, Seung-Won Choi, Jae Hwan Kim, Jong Eun Lee & Dae-Won Kim
Nature Cell Biology 9, 287–298
(March 2007); doi:10.1038/ncb1538
| Summary | Full Text (HTML / PDF) |

article
Caspase-11 regulates cell migration by promoting Aip1—Cofilin-mediated actin depolymerization
Juying Li, William M. Brieher, M. Lucila Scimone, Shin Jung Kang, Hong Zhu, Helen Yin, Ulrich H. von Andrian, Timothy Mitchison & Junying Yuan
Nature Cell Biology 9, 276–286
(March 2007); doi:10.1038/ncb1541
| Summary | Full Text (HTML / PDF) |

news and views
Moving away from death: when caspase-11 meets cofilin
Maryse Bailly
Nature Cell Biology 9, 245–246
(March 2007); doi:10.1038/ncb0307-245
| Summary | Full Text (HTML / PDF) |

review
Inhibiting transient protein—protein interactions: lessons from the Cdc25 protein tyrosine phosphatases
Johannes Rudolph
Nature Reviews Cancer 7, 202–211
(March 2007); doi:10.1038/nrc2087
| Summary | Full Text (HTML / PDF) |

letter
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
Taiping Chen, Sarah Hevi, Frédérique Gay, Naomi Tsujimoto, Timothy He, Bailin Zhang, Yoshihide Ueda & En Li
Nature Genetics 7, 391–396
(March 2007); doi:10.1038/ng1982
| Summary | Full Text (HTML / PDF) |

news and views
DNMT1 knockout delivers a strong blow to genome stability and cell viability
Kevin D Brown & Keith D Robertson
Nature Genetics 7, 289–290
(March 2007); doi:10.1038/ng0307-289
| Summary | Full Text (HTML / PDF) |

review
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Arlene H Sharpe, E John Wherry, Rafi Ahmed & Gordon J Freeman
Nature Immunology 8, 239–245
(March 2007); doi:10.1038/ni1443
| Summary | Full Text (HTML / PDF) |

article
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
Philipp A Lang, Marcus Schenck, Jan P Nicolay, Jan Ulrich Becker, Daniela S Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A Klarl, Herbert Rübben, Kurt W Schmid, Klaus Mann, Sibylle Hildenbrand, Harald Hefter, Stephan M Huber, Thomas Wieder, Andreas Erhardt, Dieter Häussinger, Erich Gulbins & Florian Lang
Nature Medicine 13, 164–170
(February 2007); doi:10.1038/nm1539
| Summary | Full Text (HTML / PDF) |

review
Myelodysplastic syndromes: the complexity of stem-cell diseases
Seth J. Corey, Mark D. Minden, Dwayne L. Barber, Hagop Kantarjian, Jean C. Y. Wang and Aaron D. Schimmer
Nature Reviews Cancer 7, 118–129
(February 2007); doi:10.1038/nrc2047
| Summary | Full Text (HTML / PDF) |

article
The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
Jiyong Liang, Shan H. Shao, Zhi-Xiang Xu, Bryan Hennessy, Zhiyong Ding, Michelle Larrea, Seiji Kondo, Dan J. Dumont, Jordan U. Gutterman, Cheryl L. Walker, Joyce M. Slingerland & Gordon B. Mills
Nature Cell Biology 9, 218–224
(February 2007); doi:10.1038/ncb1537
| Summary | Full Text (HTML / PDF) |

article
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
Ewen Gallagher, Thomas Enzler, Atsushi Matsuzawa, Amy Anzelon-Mills, Dennis Otero, Ryan Holzer, Edith Janssen, Min Gao & Michael Karin
Nature Immunology 8, 57–63
(January 2007); doi:10.1038/ni1421
| Summary | Full Text (HTML / PDF) |

letter
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
Jean-Antoine Ribeil, Yael Zermati, Julie Vandekerckhove, Severine Cathelin, Joelle Kersual, Michaël Dussiot, Séverine Coulon, Ivan Cruz Moura, Ann Zeuner, Thomas Kirkegaard-Sørensen, Bruno Varet, Eric Solary, Carmen Garrido and Olivier Hermine
Nature 445, 102–105
(4 January 2007); doi:10.1038/nature05378
| First Paragraph | Full Text (HTML / PDF) |

letter
Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis
Cristina Manjón, Ernesto Sánchez-Herrero & Magali Suzanne
Nature Cell Biology 9, 57–63
(January 2007); doi:10.1038/ncb1518
| First Paragraph | Full Text (HTML / PDF) |

news and views
Sculpting a fly leg: BMP boundaries and cell death
Marco Milán
Nature Cell Biology 9, 17–18
(January 2007); doi:10.1038/ncb0107-17
| Summary | Full Text (HTML / PDF) |

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