Research library: Cancer
2002: December
| November | October
| September | August
| July | June
| May | April
| March | February
| January
Other Years: 2003 | 2004 | 2005 | 2006 | 2007 | 2008
December
brief communication
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J. Romanienko, Julio C. Morales, Kazuhito Naka, Zhenfang Xia, R. Daniel Camerini-Otero, Noboru Motoyama, Phillip B. Carpenter, William M. Bonner, Junjie Chen and André Nussenzweig
Nature Cell Biology 4, 993–997
(December 2002); doi:10.1038/ncb884
| First Paragraph | Full Text (HTML/PDF) |
brief communication
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
Richard A. DiTullio, Jr Tamara A. Mochan, Monica Venere, Jirina Bartkova, Maxwell Sehested, Jiri Bartek and Thanos D. Halazonetis
Nature Cell Biology 4, 998–1002
(December 2002); doi:10.1038/ncb892
| First Paragraph | Full Text (HTML/PDF) |
news and views
Checkpoint signalling: focusing on 53BP1
Robert T. Abraham
Nature Cell Biology 4, E277
(December 2002); doi:10.1038/ncb1202-e277
| Full Text (HTML/PDF) |
article
T cells require TRAIL for optimal graft-versus-tumor activity
Cornelius Schmaltz, Onder Alpdogan, Barry J. Kappel, Stephanie J. Muriglan, Jimmy A. Rotolo, Jennifer Ongchin, Lucy M. Willis, Andrew S. Greenberg, Jeffrey M. Eng, James M. Crawford, George F. Murphy, Hideo Yagita, Henning Walczak, Jacques J. Peschon and Marcel R.M. van den Brink
Nature Medicine 8, 1433–1437
(December 2002); doi:10.1038/nm797
| Abstract | Full Text (HTML/PDF) |
news and views
Crowd control in the crypt
Catherine Booth, Gerard Brady and Christopher S. Potten
Nature Medicine 8, 1360–1361
(December 2002); doi:10.1038/nm1202-1360
| Full Text (HTML/PDF) |
review article
Pancreatic cancer biology and genetics
Nabeel Bardeesy and Ronald A. DePinho
Nature Reviews Cancer 2, 897–909
(December 2002); doi:10.1038/nrc949
| Summary | Full Text (HTML / PDF) |
review article
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
Teru Hideshima and Kenneth C. Anderson
Nature Reviews Cancer 2, 927–937
(December 2002); doi:10.1038/nrc952
| Summary | Full Text (HTML / PDF) |
article
A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth
Andreas G. Niethammer, Rong Xiang, Jürgen C. Becker, Harald Wodrich, Ursula Pertl, Gabriele Karsten, Brian P. Eliceiri and Ralph A. Reisfeld
Nature Medicine 8, 1369–1375
(December 2002); doi:10.1038/nm794
| Abstract | Full Text (HTML/PDF) |
news and views
Vessel maneuvers: Vaccine targets tumor vasculature
Michael S. O'Reilly
Nature Medicine 8, 1352–1353
(December 2002); doi:10.1038/nm1202-1352
| | Full Text (HTML/PDF) |
review article
Bloodborne biomolecular markers in prostate cancer development and progression
Robert A. Bok and Eric J. Small
Nature Reviews Cancer 2, 918–926
(December 2002); doi:10.1038/nrc951
| Summary | Full Text (HTML / PDF) |
review article
The retinoblastoma tumour suppressor in development and cancer
Marie Classon and Ed Harlow
Nature Reviews Cancer 2, 910–917
(December 2002); doi:10.1038/nrc950
| Summary | Full Text (HTML / PDF) |
news and views
Tumour suppression: something for nothing?
Elisa de Stanchina and Scott W. Lowe
Nature Cell Biology 4, E275
(December 2002); doi:10.1038/ncb1202-e275
| Full Text (HTML/PDF) |
review article
Lymphoid Malignancies: the dark side of B-cell differentiation
A. L. Shaffer, Andreas Rosenwald and Louis M. Staudt
Nature Reviews Immunology 2, 920–933
(December 2002); doi:10.1038/nri953
| Summary | Full Text (HTML / PDF) |
review article
Oncolytic viruses
E. Antonio Chiocca
Nature Reviews Cancer 2, 938–950
(December 2002); doi:10.1038/nrc948
| Summary | Full Text (HTML / PDF) |
perspectives
Timeline: Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Stephen M. Dilworth
Nature Reviews Cancer 2, 951–956
(December 2002); doi:10.1038/nrc946
| Summary | Full Text (HTML / PDF) |
November
news and views
Circadian rhythms: The cancer connection
Michael Rosbash and Joseph S. Takahashi
Nature 420, 373–374
(28 November 2002); doi:10.1038/420373a
| Full Text (HTML / PDF) |
article
BID regulation by p53 contributes to chemosensitivity
Joanna K. Sax, Peiwen Fei, Maureen E. Murphy, Eric Bernhard, Stanley J. Korsmeyer and Wafik S. El-Deiry
Nature Cell Biology 4, 842–849
(November 2002); doi:10.1038/ncb866
| Abstract | Full Text (HTML/PDF) |
article
Direct coupling of the cell cycle and cell death machinery by E2F
Zaher Nahle, Julia Polakoff, Ramana V. Davuluri, Mila E. McCurrach, Matthew D. Jacobson, Masashi Narita, Michael Q. Zhang, Yuri Lazebnik, Dafna Bar-Sagi and Scott W. Lowe
Nature Cell Biology 4, 859–864
(November 2002); doi:10.1038/ncb868
| Abstract | Full Text (HTML/PDF) |
review article
Natural selection of tumor variants in the generation of “tumor escape” phenotypes
Hung T. Khong and Nicholas P. Restifo
Nature Immunology 3, 999–1005
(November 2002); doi:10.1038/ni1102-999
| Abstract | Full Text (HTML/PDF) |
article
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Luca Pellegrini, David S. Yu, Thomas Lo, Shubha Anand, MiYoung Lee, Tom L. Blundell and Ashok R. Venkitaraman
Nature 420, 287–293
(21 November 2002); doi:10.1038/nature01230
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Super p53
Barbara Marte
Nature 420, 279
(21 November 2002); doi:10.1038/420279a
| Full Text (HTML / PDF) |
original paper
Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells
Wendy J Ingram, Carol A Wicking, Sean M Grimmond, Alistair R Forrest and Brandon J Wainwright
Oncogene 21, 8196–8205
(November 2002); doi:10.1038/sj.onc.1205975
| Abstract |
review article
Cancer immunoediting: from immunosurveillance to tumor escape
Gavin P. Dunn, Allen T. Bruce, Hiroaki Ikeda, Lloyd J. Old and Robert D. Schreiber
Nature Immunology 3, 991–998
(November 2002); doi:10.1038/ni1102-991
| Abstract | Full Text (HTML/PDF) |
article
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis
Richard Sharp, Juan A. Recio, Chamelli Jhappan, Toshiyuki Otsuka, Shiquan Liu, Yanlin Yu, Wenjing Liu, Miriam Anver, Fariba Navid, Lee J. Helman, Ronald A. DePinho and Glenn Merlino
Nature Medicine 8, 1276–1280
(November 2002); doi:10.1038/nm787
| Abstract | Full Text (HTML/PDF) |
news and views
Muscling in on rhabdomyosarcoma
Webster K. Cavenee
Nature Medicine 8, 1200–1201
(November 2002); doi:10.1038/nm1102-1200
| Full Text (HTML/PDF) |
brief communication
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
Keisuke Kurose, Kristie Gilley, Satoshi Matsumoto, Peter H. Watson, Xiao-Ping Zhou and Charis Eng
Nature Genetics 32, 355–357
(November 2002); doi:10.1038/ng1013
| First Paragraph | Full Text (HTML/PDF) |
brief communication
NF-kB2 p100 is a pro-apoptotic protein with anti-oncogenic function
Yongqing Wang, Hongjuan Cui, Allen Schroering, Jane L. Ding, William S. Lane, Gaël McGill, David E. Fisher and Han-Fei Ding
Nature Cell Biology 4, 888–893
(November 2002); doi:10.1038/ncb872
| First Paragraph | Full Text (HTML/PDF) |
news and views
Converting p53 from a killer into a healer
Andrei V. Gudkov
Nature Medicine 8, 1196–1198
(November 2002); doi:10.1038/nm1102-1196
| Full Text (HTML/PDF) |
review article
The pathogenesis of pituitary tumours
Sylvia L. Asa and Shereen Ezzat
Nature Reviews Cancer 2, 836–849
(November 2002); doi:10.1038/nrc926
| Summary | Full Text (HTML / PDF) |
original paper
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
Jessica Pamment, Eleanor Ramsay, Michael Kelleher, David Dornan & Kathryn L Ball
Oncogene 21, 7776–7785
(7 November 2002); doi:10.1038/sj.onc.1205981
| Abstract |
article
Functional PPAR-g receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas
Anthony P. Heaney, Manory Fernando, William H. Yong and Shlomo Melmed
Nature Medicine 8, 1281–1287
(November 2002); doi:10.1038/nm784
| Abstract | Full Text (HTML/PDF) |
October
letters to nature
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
Hongwu Zheng, Han You, Xiao Zhen Zhou, Stephen A. Murray, Takafumi Uchida, Gerburg Wulf, Ling Gu, Xiaoren Tang, Kun Ping Lu and Zhi-Xiong Jim Xiao
Nature 419, 849–853
(24 October 2002); doi:10.1038/nature01116
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
Paola Zacchi , Monica Gostissa, Takafumi Uchida, Clio Salvagno, Fabio Avolio, Stefano Volinia, Ze'ev Ronai, Giovanni Blandino, Claudio Schneider and Giannino Del Sal
Nature 419, 853–857
(24 October 2002); doi:10.1038/nature01120
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Pinning a change on p53
Kevin M. Ryan and Karen H. Vousden
Nature 419, 795–797
(24 October 2002); doi:10.1038/419795a
| Full Text (HTML / PDF) |
news and views
Cell biology: Survival in three dimensions
Kenneth M. Yamada and Katherine Clark
Nature 419, 790–791
(24 October 2002); doi:10.1038/419790a
| Full Text (HTML / PDF) |
letters to nature
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
Joan Seoane, Hong-Van Le and Joan Massagué
Nature 419, 729–734
(17 October 2002); doi:10.1038/nature01119
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
Veronika Groh, Jennifer Wu, Cassian Yee and Thomas Spies
Nature 419, 734–738
(17 October 2002); doi:10.1038/nature01112
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Catch us if you can
Wayne M. Yokoyama
Nature 419, 679–680
(17 October 2002); doi:10.1038/419679a
| Full Text (HTML / PDF) |
article
Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-a-inducible genes
Mei Huang, Feng Qian, Yuanyu Hu, Chengeng Ang, Zhong Li and Zilong Wen
Nature Cell Biology 4, 774–781
(October 2002); doi:10.1038/ncb855
| First Paragraph | Full Text (HTML/PDF) |
review article
Furin at the cutting edge: From protein traffic to embryogenesis and disease
Gary Thomas
Nature Reviews Molecular Cell Biology 3, 753–766
(October 2002); doi:10.1038/nrm934
| Summary | Full Text (HTML/PDF) |
article
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
Giuseppe Viglietto, Maria Letizia Motti, Paola Bruni, Rosa Marina Melillo, Amelia D'Alessio, Daniela Califano, Floriana Vinci, Gennaro Chiappetta, Philip Tsichlis, Alfonso Bellacosa, Alfredo Fusco and Massimo Santoro
Nature Medicine 8, 1136–1144
(October 2002); doi:10.1038/nm762
| Abstract | Full Text (HTML/PDF) |
article
PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization
Incheol Shin, F Michael Yakes, Federico Rojo, Nah-Young Shin, Andrei V. Bakin, Jose Baselga and Carlos L. Arteaga
Nature Medicine 8, 1145–1152
(October 2002); doi:10.1038/nm759
| Abstract | Full Text (HTML/PDF) |
article
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
Jiyong Liang, Judit Zubovitz, Teresa Petrocelli, Rouslan Kotchetkov, Michael K. Connor, Kathy Han, Jin-Hwa Lee, Sandra Ciarallo, Charles Catzavelos, Richard Beniston, Edmee Franssen and Joyce M. Slingerland
Nature Medicine 8, 1153–1160
(October 2002); doi:10.1038/nm761
| Abstract | Full Text (HTML/PDF) |
news and views
Breast cancer banishes p27 from nucleus
Stacy W. Blain and Joan Massagué
Nature Medicine 8, 1076–1078
(October 2002); doi:10.1038/nm1002-1076
| Full Text (HTML/PDF) |
review article
c-myc: more than just a matter of life and death
Stella Pelengaris, Mike Khan and Gerard Evan
Nature Reviews Cancer 2, 764–776
(October 2002); doi:10.1038/nrc904
| Summary | Full Text (HTML/PDF) |
review article
Transcription factors as targets for cancer therapy
James E. Darnell Jr,
Nature Reviews Cancer 2, 740–749
(October 2002); doi:10.1038/nrc906
| Summary | Full Text (HTML / PDF) |
letters to nature
Reaction path of protein farnesyltransferase at atomic resolution
Stephen B. Long, Patrick J. Casey and Lorena S. Beese
Nature 419, 645–650
(10 October 2002); doi:10.1038/nature00986
| First Paragraph | Full Text (HTML / PDF) |
review article
Clinical translation of angiogenesis inhibitors
Robert Kerbel and Judah Folkman
Nature Reviews Cancer 2, 727–739
(October 2002); doi:10.1038/nrc905
| Summary | Full Text (HTML / PDF) |
letter
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
Juan A. Bernal, Rosa Luna, Águeda Espina, Icíar Lázaro, Francisco Ramos-Morales, Francisco Romero, Carmen Arias, Augusto Silva, María Tortolero and José A. Pintor-Toro
Nature Genetics 32, 306–311
(October 2002); doi:10.1038/ng997
| First Paragraph | Full Text (HTML/PDF) |
news and views
Securin a new role for itself
Anil K. Rustgi
Nature Genetics 32, 222–224
(October 2002); doi:10.1038/ng1002-222
| Full Text (HTML/PDF) |
original paper
Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein
Kyeong-Sook Lee, Seung-Hyun Hong & Suk-Chul Bae
Oncogene 21, 7156–7163
(17 October 2002); doi:10.1038/sj.onc.1205937
| First Paragraph |
article
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Mirella Lazarov, Yoshiaki Kubo, Ti Cai, Maya Dajee, Masahito Tarutani, Qun Lin, Min Fang, Shiying Tao, Cheryl L. Green and Paul A. Khavari
Nature Medicine 8, 1105–1114
(October 2002); doi:10.1038/nm779
| Abstract | Full Text (HTML/PDF) |
perspectives
Timeline: VEGF and the quest for tumour angiogenesis factors
Napoleone Ferrara
Nature Reviews Cancer 2, 795–803
(October 2002); doi:10.1038/nrc909
| Summary | Full Text (HTML / PDF) |
September
review article
The bcl2 family: regulators of the cellular life-or-death switch
Suzanne Cory and Jerry M. Adams
Nature Reviews Cancer 2, 647–656
(September 2002); doi:10.1038/nrc883
| Summary | Full Text (HTML / PDF) |
letter
New genes involved in cancer identified by retroviral tagging
Takeshi Suzuki, Haifa Shen, Keiko Akagi, Herbert C Morse, III James D Malley, Daniel Q Naiman, Nancy A Jenkins and Neal G Copeland
Nature Genetics 32, 166–174
(September 2002); doi:10.1038/ng949
| First Paragraph | Full Text (HTML/PDF) |
letter
BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair
Anne-Renee Hartman and James M. Ford
Nature Genetics 32, 180–184
(September 2002); doi:10.1038/ng953
| First Paragraph | Full Text (HTML/PDF) |
article
Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
Shogo Ishiuchi, Keisuke Tsuzuki, Yukari Yoshida, Nobuaki Yamada, Norikazu Hagimura, Haruo Okado, Akiko Miwa, Hideyuki Kurihara, Yoichi Nakazato, Masaru Tamura, Tomio Sasaki and Seiji Ozawa
Nature Medicine 8, 971–978
(September 2002); doi:10.1038/nm746
| Abstract | Full Text (HTML/PDF) |
news and views
Paving new pathways
Jeffrey D. Rothstein
Nature Medicine 8, 938–940
(September 2002); doi:10.1038/nm0902-938
| Full Text (HTML/PDF) |
letters to nature
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
Nabeel Bardeesy, Manisha Sinha, Aram F. Hezel, Sabina Signoretti, Nathaniel A. Hathaway, Norman E. Sharpless, Massimo Loda, Daniel R. Carrasco and Ronald A. DePinho
Nature 419, 162–167
(12 September 2002); doi:10.1038/nature01045
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Stuck at first base
Louise van der Weyden, Jos Jonkers and Allan Bradley
Nature 419, 127–128
(12 September 2002); doi:10.1038/419127a
| Full Text (HTML/PDF) |
review article
Nf-kb, chemokine gene transcription and tumour growth
Ann Richmond
Nature Reviews Immunology 2, 664–674
(September 2002); doi:10.1038/nri887
| Abstract | Full Text (HTML/PDF) |
article
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
Sanne Weijzen, Paola Rizzo, Mike Braid, Radhika Vaishnav, Suzanne M. Jonkheer, Andrei Zlobin, Barbara A. Osborne, Sridevi Gottipati, Jon C. Aster, William C. Hahn, Michael Rudolf, Kalliopi Siziopikou, W. Martin Kast and Lucio Miele
Nature Medicine 8, 979–986
(September 2002); doi:10.1038/nm754
| Abstract | Full Text (HTML/PDF) |
review article
Molecular basis of the VHL hereditary cancer syndrome
William G. Kaelin Jr
Nature Reviews Cancer 2, 673–682
(September 2002); doi:10.1038/nrc885
| Abstract | Full Text (HTML/PDF) |
letter
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice
Anders H. Lund, Geoffrey Turner, Alla Trubetskoy, Els Verhoeven, Ellen Wientjens, Danielle Hulsman, Robert Russell, Ronald A. DePinho, Jack Lenz and Maarten van Lohuizen
Nature Genetics 32, 160–165
(September 2002); doi:10.1038/ng956
| First Paragraph | Full Text (HTML/PDF) |
original paper
Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene
Kristen C Johnson, Joseph L Kissil, Jessica L Fry & Tyler Jacks
Oncogene 21, 5990–5997
(5 September 2002); doi:10.1038/sj.onc.1205693
| Full Text (HTML/PDF) |
article
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu and Kun-Liang Guan
Nature Cell Biology 4, 648–657
(September 2002); doi:10.1038/ncb839
| Abstract | Full Text (HTML/PDF) |
article
Akt regulates growth by directly phosphorylating Tsc2
Christopher J. Potter, Laura G. Pedraza and Tian Xu
Nature Cell Biology 4, 658–665
(September 2002); doi:10.1038/ncb840
| Abstract | Full Text (HTML/PDF) |
brief communication
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
Xinsheng Gao, Yong Zhang, Peter Arrazola, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Binggeng Ru and Duojia Pan
Nature Cell Biology 4, 699–704
(September 2002); doi:10.1038/ncb847
| First Paragraph | Full Text (HTML/PDF) |
news and views
TSC1-TSC2: a complex tale of PKB-mediated S6K regulation
Edward J. McManus and Dario R. Alessi
Nature Cell Biology 4, E214
(September 2002); doi:10.1038/ncb0902-e214
| Full Text (HTML/PDF) |
review article
Strategies for mmp inhibition in cancer: innovations for the post-trial era
Christopher Mark Overall and Carlos López-Otín
Nature Reviews Cancer 2, 657–672
(September 2002); doi:10.1038/nrc884
| Summary | Full Text (HTML / PDF) |
letter
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
Harald Mikkers, John Allen, Puck Knipscheer, Lieke Romeyn, Augustinus Hart, Edwin Vink and Anton Berns
Nature Genetics 32, 153–159
(September 2002); doi:10.1038/ng950
| First Paragraph | Full Text (HTML/PDF) |
research article
Inhibition of glioma growth by tumor-specific activation of double-stranded RNA-dependent protein kinase PKR
Alexei Shir and Alexander Levitzki
Nature Biotechnology 20, 895–900
(September 2002); doi:10.1038/nbt730
| Abstract | Full Text (HTML/PDF) |
August
article
Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Zoltan A. Nagy, Bernd Hubner, Corinna Löhning, Robert Rauchenberger, Silke Reiffert, Elisabeth Thomassen-Wolf, Stefan Zahn, Sigmar Leyer, Eva M. Schier, Angelika Zahradnik, Christoph Brunner, Kurt Lobenwein, Benno Rattel, Michael Stanglmaier, Michael Hallek, Mark Wing, Steve Anderson, Matt Dunn, Titus Kretzschmar and Michael Tesar
Nature Medicine 8, 801–807
(August 2002); doi:10.1038/nm736
| Abstract | Full Text (HTML/PDF) |
news and views
DR's orders: Human antibody kills tumors by direct signaling
Dan L. Longo
Nature Medicine 8, 781–783
(August 2002); doi:10.1038/nm0802-781
| Full Text (HTML/PDF) |
article
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis and Lieping Chen
Nature Medicine 8, 793–800
(August 2002); doi:10.1038/nm730
| Abstract | Full Text (HTML/PDF) |
news and views
Protect the killer: CTLs need defenses against the tumor
Gordon J. Freeman, Arlene H. Sharpe and Vijay K. Kuchroo
Nature Medicine 8, 787–789
(August 2002); doi:10.1038/nm0802-787
| Full Text (HTML/PDF) |
article
Gene-expression profiles predict survival of patients with lung adenocarcinoma
David G. Beer, Sharon L.R. Kardia, Chiang-Ching Huang, Thomas J. Giordano, Albert M. Levin, David E. Misek, Lin Lin, Guoan Chen, Tarek G. Gharib, Dafydd G. Thomas, Michelle L. Lizyness, Rork Kuick, Satoru Hayasaka, Jeremy M.G. Taylor, Mark D. Iannettoni, Mark B. Orringer and Samir Hanash
Nature Medicine 8, 816–824
(August 2002); doi:10.1038/nm733
| Abstract | Full Text (HTML/PDF) |
progress
Molecular pathogenesis of human hepatocellular carcinoma
Snorri S. Thorgeirsson and Joe W. Grisham
Nature Genetics 31, 339–346
(August 2002); doi:10.1038/ng0802-339
| Abstract | Full Text (HTML/PDF) |
letters to nature
Patched acts catalytically to suppress the activity of Smoothened
J. Taipale, M. K. Cooper, T. Maiti and P. A. Beachy
Nature 418, 892–896
(22 August 2002); doi:10.1038/nature00989
| First Paragraph | Full Text (HTML / PDF) |
brief communication
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
Egle Avizienyte, Anne W. Wyke, Robert J. Jones, Gordon W. McLean, M. Andrew Westhoff, Valerie G. Brunton and Margaret C. Frame
Nature Cell Biology 4, 632–638
(August 2002); doi:10.1038/ncb829
| First Paragraph | Full Text (HTML/PDF) |
review article
Live or let die: the cell's response to p53
Karen H. Vousden and Xin Lu
Nature Reviews Cancer 2, 594–604
(August 2002); doi:10.1038/nrc864
| Summary | Full Text (HTML / PDF) |
review article
Metastasis to bone: causes, consequences and therapeutic opportunities
Gregory R. Mundy
Nature Reviews Cancer 2, 584–593
(August 2002); doi:10.1038/nrc867
| Summary | Full Text (HTML / PDF) |
article
Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology
Cristina Fernandez-Valle, Yong Tang, Jerome Ricard, Alma Rodenas-Ruano, Anna Taylor, Elizabeth Hackler, John Biggerstaff and Jared Iacovelli
Nature Genetics 31, 354–362
(August 2002); doi:10.1038/ng930
| Abstract | Full Text (HTML/PDF) |
letters to nature
A naturally occurring MTA1 variant sequesters oestrogen receptor-a in the cytoplasm
Rakesh Kumar, Rui-An Wang, Abhijit Mazumdar, Amjad H. Talukder, Mahitosh Mandal, Zhibo Yang, Rozita Bagheri-Yarmand, Aysegul Sahin, Gabriel Hortobagyi, Liana Adam, Christopher J. Barnes and Ratna K. Vadlamudi
Nature 418, 654–657
(8 August 2002); doi:10.1038/nature00889
| First Paragraph | Full Text (HTML / PDF) |
review article
p73: Friend or foe in tumorigenesis
Gerry Melino, Vincenzo De Laurenzi and Karen H. Vousden
Nature Reviews Cancer 2, 605–615
(August 2002); doi:10.1038/nrc861
| Abstract | Full Text (HTML/PDF) |
review article
The Molecular and Genetic Basis of Neurological Tumours
Yuan Zhu and Luis F. Parada
Nature Reviews Cancer 2, 616–626
(August 2002); doi:10.1038/nrc866
| Abstract | Full Text (HTML/PDF) |
article
PKC-b controls IkB kinase lipid raft recruitment and activation in response to BCR signaling
Thomas T. Su, Beichu Guo, Yuko Kawakami, Karen Sommer, Keun Chae, Lisa A. Humphries, Roberta M. Kato, Shin Kang, Lisa Patrone, Randolph Wall, Michael Teitell, Michael Leitges, Toshiaki Kawakami and David J. Rawlings
Nature Immunology 3, 780–786
(August 2002); doi:10.1038/ni823
| Abstract | Full Text (HTML/PDF) |
article
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
Simone Fulda, Wolfgang Wick, Michael Weller and Klaus-Michael Debatin
Nature Medicine 8, 808–815
(August 2002); doi:10.1038/nm735
| Abstract | Full Text (HTML/PDF) |
article
Elevated JNK activation contributes to the pathogenesis of human brain tumors
Oncogene 21, 5038–5046
(August 2002); doi:10.1038/sj.onc.1205593
| Abstract |
July
brief communication
Nucleophosmin regulates the stability and transcriptional activity of p53
Emanuela Colombo, Jean-Christophe Marine, Davide Danovi, Brunangelo Falini and Pier Giuseppe Pelicci
Nature Cell Biology 4, 529–533
(July 2002); doi:10.1038/ncb814
| First Paragraph | Full Text (HTML/PDF) |
article
The t(8;21) fusion protein, AML1-ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia
Bryan Linggi, Carsten Müller-Tidow, Louis van de Locht, Ming Hu, John Nip, Hubert Serve, Wolfgang E. Berdel, Bert van der Reijden, Dawn E. Quelle, Janet D. Rowley, John Cleveland, Joop H. Jansen, Pier Paolo Pandolfi and Scott W. Hiebert
Nature Medicine 8, 743–750
(July 2002); doi:10.1038/nm726
| Abstract | Full Text (HTML/PDF) |
news and views
Burning up TNF toxicity for cancer therapy
Marcel Leist and Marja Jäättelä
Nature Medicine 8, 667–668
(July 2002); doi:10.1038/nm0702-667
| Full Text (HTML/PDF) |
review article
LKB1 — A master tumour suppressor of the small intestine and beyond
Lina I. Yoo, Daniel C. Chung and Junying Yuan
Nature Reviews Cancer 2, 529–535
(July 2002); doi:10.1038/nrc843
| Abstract | Full Text (HTML/PDF) |
letter
Mutations in SUFU predispose to medulloblastoma
Michael D. Taylor, Ling Liu, Corey Raffel, Chi-chung Hui, Todd G. Mainprize, Xiaoyun Zhang, Ron Agatep, Sharon Chiappa, Luzhang Gao, Anja Lowrance, Aihau Hao, Alisa M. Goldstein, Theodora Stavrou, Stephen W. Scherer, Wieslaw T. Dura, Brandon Wainwright, Jeremy A. Squire, James T. Rutka and David Hogg
Nature Genetics 31, 306–310
(July 2002); doi:10.1038/ng916
| First Paragraph | Full Text (HTML/PDF) |
review article
CTLA-4: new insights into its biological function and use in tumor immunotherapy
Jackson G. Egen, Michael S. Kuhns and James P. Allison
Nature Immunology 3, 611–618
(July 2002); doi:10.1038/ni0702-611
| Abstract | Full Text (HTML/PDF) |
letter
Truncating mutations of RB1CC1 in human breast cancer
Tokuhiro Chano, Keiichi Kontani, Koji Teramoto, Hidetoshi Okabe and Shiro Ikegawa
Nature Genetics 31, 285–288
(July 2002); doi:10.1038/ng911
| First Paragraph | Full Text (HTML/PDF) |
news and views
Efp: A ring of independence?
Grzegorz Nalepa and J. Wade Harper
Nature Medicine 8, 661–662
(July 2002); doi:10.1038/nm0702-661
| Full Text (HTML/PDF) |
review article
Roles of heparan-sulphate glycosaminoglycans in cancer
Ram Sasisekharan, Zachary Shriver, Ganesh Venkataraman and Uma Narayanasami
Nature Reviews Cancer 2, 521–528
(July 2002); doi:10.1038/nrc842
| Abstract | Full Text (HTML/PDF) |
review article
The phosphatidylinositol 3-Kinase-AKT pathway in human cancer
Igor Vivanco and Charles L. Sawyers
Nature Reviews Cancer 2, 489–501
(July 2002); doi:10.1038/nrc839
| Abstract | Full Text (HTML/PDF) |
review article
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
Renaud Capdeville, Elisabeth Buchdunger, Juerg Zimmermann and Alex Matter
Nature Reviews Drug Discovery 1, 493–502
(July 2002); doi:10.1038/nrd839
| Abstract | Full Text (HTML/PDF) |
review article
Nucleic-acid therapeutics: basic principles and recent applications
Joanna B. Opalinska and Alan M. Gewirtz
Nature Reviews Drug Discovery 1, 503–514
(July 2002); doi:10.1038/nrd837
| Abstract | Full Text (HTML/PDF) |
June
letter
Mutations of the BRAF gene in human cancer
Helen Davies, Graham R. Bignell, Charles Cox, Philip Stephens et al.
Nature 417, 949–954
(27 June 2002); doi:10.1038/nature00766
| First Paragraph | Full Text (HTML/PDF) |
news and views
Cancer: Lucky draw in the gene raffle
Pamela M. Pollock and Paul S. Meltzer
Nature 417, 906–907
(27 June 2002); doi:10.1038/417906a
| Full Text (HTML/PDF) |
article
ROCK and Dia have opposing effects on adherens junctions downstream of Rho
Erik Sahai and Christopher J. Marshall
Nature Cell Biology 4, 408–415
(June 2002); doi:10.1038/ncb796
| Abstract | Full Text (HTML/PDF) |
commentary
Targeting the endocannabinoid system in cancer therapy: A call for further research
Maurizio Bifulco and Vincenzo Di Marzo
Nature Medicine 8, 547–550
(June 2002); doi:10.1038/nm0602-547
| Full Text (HTML/PDF) |
review article
Epithelial-mesenchymal transitions in tumour progression
Jean Paul Thiery
Nature Reviews Cancer 2, 442–454
(June 2002); doi:10.1038/nrc822
| Abstract | Full Text (HTML/PDF) |
letter to nature
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
Angeliki Malliri, Rob A. van der Kammen, Kristopher Clark, Maarten van der Valk, Frits Michiels and John G. Collard
Nature417, 867–871
(20 June 2002); doi:10.1038/nature00848
| First Paragraph | Full Text (HTML/PDF) |
letter to nature
Efp targets 14-3-3s for proteolysis and promotes breast tumour growth
Tomohiko Urano, Tomoyuki Saito, Tohru Tsukui, Masayo Fujita, Takayuki Hosoi, Masami Muramatsu, Yasuyoshi Ouchi and Satoshi Inoue
Nature 417, 871–875
(20 June 2002); doi:10.1038/nature00826
| First Paragraph | Full Text (HTML/PDF) |
news and views
p53 de-ubiquitination: at the edge between life and death
Paolo Salomoni and Pier Paolo Pandolfi
Nature Cell Biology 4, E152
(June 2002); doi:10.1038/ncb0602-e152
| Full Text (HTML/PDF) |
news and views
Mini p53
Valerie Ferrier
Nature Cell Biology 4, E156
(June 2002); doi:10.1038/ncb0602-e156
| Full Text (HTML/PDF) |
meeting report
Life and death in paradise
Or Gozani, Michael Boyce, Lina Yoo, Philip Karuman and Junying Yuan
Nature Cell Biology 4, E159
(June 2002); doi:10.1038/ncb0602-e159
| First Paragraph | Full Text (HTML/PDF) |
article
Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus
Corina M. Borza and Lindsey M. Hutt-Fletcher
Nature Medicine 8, 594–599
(June 2002); doi:10.1038/nm0602-594
| Abstract | Full Text (HTML/PDF) |
news and views
Cell-switching and kissing
Paul J. Farrell
Nature Medicine 8, 559–560
(June 2002); doi:10.1038/nm0602-559
| Full Text (HTML/PDF) |
news and views
FANCD2: A branch-point in DNA damage response?
Markus Grompe
Nature Medicine 8, 555–556
(June 2002); doi:10.1038/nm0602-555
| Full Text (HTML/PDF) |
review article
Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses
Cassian Yee and Philip Greenberg
Nature Reviews Cancer 2, 409–419
(June 2002); doi:10.1038/nrc820
| Abstract | Full Text (HTML/PDF) |
letter
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry
Marina Lomazzi, M. Cristina Moroni, Michael R. Jensen, Emanuela Frittoli and Kristian Helin
Nature Genetics 31, 190–194
(June 2002); doi:10.1038/ng891
| First Paragraph | Full Text (HTML/PDF) |
review article
Mechanisms of smoking-related lung and pancreatic adenocarcinoma development
Hildegard M. Schuller
Nature Reviews Cancer 2, 455–463
(June 2002); doi:10.1038/nrc824
| Abstract | Full Text (HTML/PDF) |
review article
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Avi Ashkenazi
Nature Reviews Cancer 2, 420–430
(June 2002); doi:10.1038/nrc821
| Abstract | Full Text (HTML/PDF) |
brief communication
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
Jing Li, Ying Yang, Yue Peng, Richard J. Austin, Winfried G. van Eyndhoven, Ken C. Q. Nguyen, Tim Gabriele, Mila E. McCurrach, Jeffrey R. Marks, Timothy Hoey, Scott W. Lowe & Scott Powers
Nature Genetics 31, 133–134
(June 2002); doi:10.1038/ng888
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Timeline: Fortuitous convergences: the beginnings of JUN
Peter K. Vogt
Nature Reviews Cancer 2, 465–469
(June 2002); doi:10.1038/nrc818
| Abstract | Full Text (HTML/PDF) |
letter
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
Dmitry V. Bulavin, Oleg N. Demidov, Shin'ichi Saito, Paivikki Kauraniemi, Crissy Phillips, Sally A. Amundson, Concetta Ambrosino, Guido Sauter, Angel R. Nebreda, Carl W. Anderson, Anne Kallioniemi, Albert J. Fornace Jr & Ettore Appella
Nature Genetics 31, 210–215
(June 2002); doi:10.1038/ng894
| First Paragraph | Full Text (HTML/PDF) |
review article
Angiogenesis modulation in cancer research: novel clinical approaches
Massimo Cristofanilli, Chusilp Charnsangavej & Gabriel N. Hortobagyi
Nature Reviews Drug Discovery 1, 415–426
(June 2002); doi:10.1038/nrd819
| Abstract | Full Text (HTML/PDF) |
May
research article
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
Paolo Michieli, Silvia Cavassa, Cristina Basilico, Annarita De Luca, Massimiliano Mazzone, Cinzia Asti, Riccardo Chiusaroli, Mario Guglielmi, Paola Bossù, Francesco Colotta, Gianfranco Caselli and Paolo M. Comoglio
Nature Biotechnology 20, 488–495
(May 2002); doi:10.1038/nbt0502-488
| Abstract | Full Text (HTML/PDF) |
review article
Papillomaviruses and cancer: from basic studies to clinical application
Harald zur Hausen
Nature Reviews Cancer 2, 342–350
(May 2002); doi:10.1038/nrc798
| Abstract | Full Text (HTML/PDF) |
review article
Aids-related malignancies
Chris Boshoff and Robin Weiss
Nature Reviews Cancer 2, 373–382
(May 2002); doi:10.1038/nrc797
| Abstract | Full Text (HTML/PDF) |
review article
ONCOGENIC TYROSINE KINASES AND THE DNA-DAMAGE RESPONSE
Tomasz Skorski
Nature Reviews Cancer 2, 351–360
(May 2002); doi:10.1038/nrc799
| Abstract | Full Text (HTML/PDF) |
review article
Modelling the molecular circuitry of cancer
William C. Hahn and Robert A. Weinberg
Nature Reviews Cancer 2, 331–341
(May 2002); doi:10.1038/nrc795
| Abstract | Full Text (HTML/PDF) |
review article
Gli and hedgehog in cancer: tumours, embryos and stem cells
Ariel Ruiz i Altaba, Pilar Sánchez and Nadia Dahmane
Nature Reviews Cancer 2, 361–372
(May 2002); doi:10.1038/nrc796
| Abstract | Full Text (HTML/PDF) |
review article
The subcellular destinations of apc proteins
Mariann Bienz
Nature Reviews Molecular Cell Biology 3, 328–338
(May 2002); doi:10.1038/nrm806
| Abstract | Full Text (HTML/PDF) |
letter
Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations
Hanne Meijers-Heijboer, Ans van den Ouweland, Jan Klijn, Marijke Wasielewski, Anja de Snoo, Rogier Oldenburg, Antoinette Hollestelle, Mark Houben, Ellen Crepin, Monique van Veghel-Plandsoen, Fons Elstrodt, Cornelia van Duijn, Carina Bartels, Carel Meijers, Mieke Schutte, Lesley McGuffog, Deborah Thompson, Douglas F. Easton, Nayanta Sodha, Sheila Seal, Rita Barfoot, Jon Mangion, Jenny Chang-Claude, Diana Eccles, Rosalind Eeles, D Gareth Evans, Richard Houlston, Victoria Murday, Steven Narod, Tamara Peretz, Julian Peto, Catherine Phelan, Hong Xiang Zhang, Csilla Szabo, Peter Devilee, David Goldgar, P Andrew Futreal, Katherine L. Nathanson, Barbara L. Weber, Nazneen Rahman and Michael R. Stratton
Nature Genetics 31, 55–59
(May 2002); doi:10.1038/ng879
| First Paragraph | Full Text (HTML/PDF) |
news and views
CHEKs and balances: accounting for breast cancer
Lawrence C. Brody
Nature Genetics 31, 3–4
(May 2002); doi:10.1038/ng0502-3
| Full Text (HTML/PDF) |
April
news and views
Mitochondria, from cell death to proliferation
Pierre Rustin
Nature Genetics 30, 352–353
(April 2002); doi:10.1038/ng0402-352
| Full Text (HTML/PDF) |
review article
CONDITIONAL MOUSE MODELS OF SPORADIC CANCER
Jos Jonkers and Anton Berns
Nature Reviews Cancer 2, 251–265
(April 2002); doi:10.1038/nrc777
| Abstract | Full Text (HTML/PDF) |
review article
DEATH AND ANTI-DEATH: TUMOUR RESISTANCE TO APOPTOSIS
Frederik H. Igney and Peter H. Krammer
Nature Reviews Cancer 2, 277–288
(April 2002); doi:10.1038/nrc776
| Abstract | Full Text (HTML/PDF) |
review article
SCATTER-FACTOR AND SEMAPHORIN RECEPTORS: CELL SIGNALLING FOR INVASIVE GROWTH
Livio Trusolino and Paolo M. Comoglio
Nature Reviews Cancer 2, 289–300
(April 2002); doi:10.1038/nrc779
| Abstract | Full Text (HTML/PDF) |
review article
NF-kB IN CANCER: FROM INNOCENT BYSTANDER TO MAJOR CULPRIT
Michael Karin, Yixue Cao, Florian R. Greten and Zhi-Wei Li
Nature Reviews Cancer 2, 301–310
(April 2002); doi:10.1038/nrc780
| Abstract | Full Text (HTML/PDF) |
review article
V-SRC'S HOLD OVER ACTIN AND CELL ADHESIONS
Margaret C. Frame, Valerie J. Fincham, Neil O. Carragher and John A. Wyke
Nature Reviews Molecular Cell Biology 3, 233–245
(April 2002); doi:10.1038/nrm779
| Abstract | Full Text (HTML/PDF) |
brief communication
Identification of a link between the tumour suppressor APC and the kinesin superfamily
Takeshi Jimbo, Yoshihiro Kawasaki, Ryo Koyama, Rina Sato, Shinji Takada, Keiko Haraguchi and Tetsu Akiyama
Nature Cell Biology 4, 323–327
(April 2002); doi:10.1038/ncb779
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
Elsa R. Flores, Kenneth Y. Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon and Tyler Jacks
Nature 416, 560–564
(April 2002); doi:10.1038/416560a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
Muyang Li, Delin Chen, Ariel Shiloh, Jianyuan Luo, Anatoly Y. Nikolaev, Jun Qin and Wei Gu
Nature 416, 648–653
(April 2002); doi:10.1038/nature737
| First Paragraph | Full Text (HTML/PDF) |
March
review article
NEW FUNCTIONS FOR THE MATRIX METALLOPROTEINASES IN CANCER PROGRESSION
Mikala Egeblad and Zena Werb
Nature Reviews Cancer 2, 163–176
(March 2002); doi:10.1038/nrc745
| Abstract | Full Text (HTML/PDF) |
review article
CHEMOKINES: AGENTS FOR THE IMMUNOTHERAPY OF CANCER?
Bernhard Homey, Anja Müller and Albert Zlotnik
Nature Reviews Immunology 2, 175–184
(March 2002); doi:10.1038/nri748
| Abstract | Full Text (HTML/PDF) |
article
Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
Rama Pai, Brian Soreghan, Imre L. Szabo, Meredith Pavelka, Dolgor Baatar and Andrzej S. Tarnawski
Nature Medicine 8, 289–293
(March 2002); doi:10.1038/nm0302-289
| Abstract | Full Text (HTML/PDF) |
letter
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
Ronit I. Yarden, Sherly Pardo-Reoyo, Magda Sgagias, Kenneth H. Cowan and Lawrence C. Brody
Nature Genetics 30, 285–289
(March 2002); doi:10.1038/ng837
| First Paragraph | Full Text (HTML/PDF) |
letter
A mutant PTH/PTHrP type I receptor in enchondromatosis
Sevan Hopyan, Nalan Gokgoz, Raymond Poon, Robert C. Gensure, Chunying Yu, William G. Cole, Robert S. Bell, Harald Jüppner, Irene L. Andrulis, Jay S. Wunder and Benjamin A. Alman
Nature Genetics 30, 306–310
(March 2002); doi:10.1038/ng844
| First Paragraph | Full Text (HTML/PDF) |
February
review article
APOPTOSIS-BASED THERAPIES
John C. Reed
Nature Reviews Drug Discovery 1, 111–121
(February 2002); doi:10.1038/nrd726
| Abstract | Full Text (HTML/PDF) |
review article
ROLE OF INTEGRINS IN CELL INVASION AND MIGRATION
John D. Hood and David A. Cheresh
Nature Reviews Cancer 2, 91–100
(February 2002); doi:10.1038/nrc727
| Abstract | Full Text (HTML/PDF) |
review article
ENDOCRINE-RESPONSIVE BREAST CANCER AND STRATEGIES FOR COMBATING RESISTANCE
Simak Ali and R. Charles Coombes
Nature Reviews Cancer 2, 101–112
(February 2002); doi:10.1038/nrc721
| Abstract | Full Text (HTML/PDF) |
review article
RHO-GTPASES AND CANCER
Erik Sahai and Christopher J. Marshall
Nature Reviews Cancer 2, 133–142
(February 2002); doi:10.1038/nrc725
| Abstract | Full Text (HTML/PDF) |
news and views
An essential link to mammary cancer?
Sibylle Tonko-Geymayer and Wolfgang Doppler
Nature Medicine 8, 108–110
(February 2002); doi:10.1038/nm0202-108
| Full Text (HTML/PDF) |
brief communication
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
Daniel S. Peeper, Avi Shvarts, Thijn Brummelkamp, Sirith Douma, Eugene Y. Koh, George Q. Daley and René Bernards
Nature Cell Biology 4, 148–153
(February 2002); doi:10.1038/ncb742
| First Paragraph | Full Text (HTML/PDF) |
letter
Structure of the Bcr-Abl oncoprotein oligomerization domain
Xun Zhao, Saghi Ghaffari, Harvey Lodish, Vladimir N. Malashkevich and Peter S. Kim
Nature Structural Biology 9, 117–120
(February 2002); doi:10.1038/nsb747
| First Paragraph | Full Text (HTML/PDF) |
January
commentary
Lymphatic endothelium: a new frontier of metastasis research
Marika J. Karkkainen, Taija Mäkinen and Kari Alitalo
Nature Cell Biology 4, E2
(January 2002); doi:10.1038/ncb0102-e2
| Full Text (HTML/PDF) |
review article
HELICOBACTER PYLORI AND GASTROINTESTINAL TRACT ADENOCARCINOMAS
Richard M. Peek & Martin J. Blaser
Nature Reviews Cancer 2, 28–37
(January 2002); doi:10.1038/nrc703
| Abstract | Full Text (HTML/PDF) |
review article
HYPOXIA — A KEY REGULATORY FACTOR IN TUMOUR GROWTH
Adrian L. Harris
Nature Reviews Cancer 2, 38–47
(January 2002); doi:10.1038/nrc704
| Abstract | Full Text (HTML/PDF) |
article
Enhanced pathological angiogenesis in mice lacking b3 integrin or b3 and b5 integrins
Louise E. Reynolds, Lorenza Wyder, Julie C. Lively, Daniela Taverna, Stephen D. Robinson, Xiaozhu Huang, Dean Sheppard, Richard O. Hynes and Kairbaan M. Hodivala-Dilke
Nature Medicine 8, 27–34
(January 2002); doi:10.1038/nm0102-27
| Abstract | Full Text (HTML/PDF) |
news and views
Integrin indecision
Peter Carmeliet
Nature Medicine 8, 14–16
(January 2002); doi:10.1038/nm0102-14
| Full Text (HTML/PDF) |
article
BCR-ABL suppresses C/EBPa expression through inhibitory action of hnRNP E2
Danilo Perrotti, Vincenzo Cesi, Rossana Trotta, Clara Guerzoni, Giorgia Santilli, Kenneth Campbell, Angela Iervolino, Fabrizio Condorelli, Carlo Gambacorti-Passerini, Michael A. Caligiuri and Bruno Calabretta
Nature Genetics 30, 48–58
(January 2002); doi:10.1038/ng791
| Abstract | Full Text (HTML/PDF) |
letters to nature
Prediction of central nervous system embryonal tumour outcome based on gene expression
Scott L. Pomeroy, Pablo Tamayo, Michelle Gaasenbeek, Lisa M. Sturla, Michael Angelo, Margaret E. McLaughlin, John Y. H. Kim, Liliana C. Goumnerova, Peter M. Black, Ching Lau, Jeffrey C. Allen, David Zagzag, James M. Olson, Tom Curran, Cynthia Wetmore, Jaclyn A. Biegel, Tomaso Poggio, Shayan Mukherjee, Ryan Rifkin, Andrea Califano, Gustavo Stolovitzky, David N. Louis, Jill P. Mesirov, Eric S. Lander and Todd R. Golub
Nature 415, 436–442
(January 2002); doi:10.1038/415436a
| First Paragraph | Full Text (HTML/PDF) |
news and views
Pten-uating neural growth
Sean J. Morrison
Nature Medicine 8, 16–18
(January 2002); doi:10.1038/nm0102-16
| Full Text (HTML/PDF) |
news and views
Ageing: The price of tumour suppression?
Gerardo Ferbeyre and Scott W. Lowe
Nature 415, 26–27
(January 2002); doi:10.1038/415026a
| Full Text (HTML/PDF) |
article
p53 mutant mice that display early ageing-associated phenotypes
Stuart D. Tyner, Sundaresan Venkatachalam, Jene Choi, Stephen Jones, Nader Ghebranious, Herbert Igelmann, Xiongbin Lu, Gabrielle Soron, Benjamin Cooper, Cory Brayton, Sang Hee Park, Timothy Thompson, Gerard Karsenty, Allan Bradley and Lawrence A. Donehower
Nature 415, 45–53
(January 2002); doi:10.1038/415045a
| Summary | Full Text (HTML/PDF) |
|
