article Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
Natalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G G C Verhoef, Maria Masucci, Aladdin Pramanik and Galina Selivanova Nature Medicine10, 1321–1328
(December 2004); doi:10.1038/nm1146
| Abstract | Full Text (HTML/PDF) |
news and views Cancer drug discovery: the wisdom of imprecision
Andrei V Gudkov Nature Medicine10, 1298–1299
(December 2004); doi:10.1038/nm1204-1298
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perspectives Timeline: Gefitinib — a novel targeted approach to treating cancer
Roy S. Herbst, Masahiro Fukuoka and José Baselga Nature Reviews Cancer4, 956–965
(December 2004); doi:10.1038/nrc1506
| Abstract | Full Text (HTML / PDF) |
article Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
Jose M Polo, Tania Dell'Oso, Stella Maris Ranuncolo, Leandro Cerchietti, David Beck, Gustavo F Da Silva, Gilbert G Prive, Jonathan D Licht and Ari Melnick Nature Medicine10, 1329–1335
(December 2004); doi:10.1038/nm1134
| Abstract | Full Text (HTML/PDF) |
review article Regulation of the cytoskeleton: an oncogenic function for cdk inhibitors?
Arnaud Besson, Richard K. Assoian and James M. Roberts Nature Reviews Cancer4, 948–955
(December 2004); doi:10.1038/nrc1501
| Abstract | Full Text (HTML / PDF) |
letters to nature Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Ryosuke Tsunematsu, Keiichi I. Nakayama, Ken Brown, Sheila Bryson and Allan Balmain Nature432, 775–779
(09 December 2004); doi:10.1038/nature03155
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review article Mechanisms and functional significance of tumour-induced dendritic-cell defects
Dmitry Gabrilovich Nature Reviews Immunology4, 941–952
(December 2004); doi:10.1038/nri1498
| Abstract | Full Text (HTML / PDF) |
review article Aurora-kinase inhibitors as anticancer agents
Nicholas Keen and Stephen Taylor Nature Reviews Cancer4, 927–936
(December 2004); doi:10.1038/nrc1502
| Abstract | Full Text (HTML / PDF) |
review article Targeting the mitogen-activated protein kinase cascade to treat cancer
Judith S. Sebolt-Leopold and Roman Herrera Nature Reviews Cancer4, 937–947
(December 2004); doi:10.1038/nrc1503
| Abstract | Full Text (HTML / PDF) |
review article Development of TGF-β signalling inhibitors for cancer therapy
Jonathan M. Yingling, Kerry L. Blanchard and J. Scott Sawyer Nature Reviews Drug Discovery3, 1011–1022
(December 2004); doi:10.1038/nrd1580
| Abstract | Full Text (HTML / PDF) |
article Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas
Akira Watahiki, Kazunori Waki, Norihito Hayatsu, Toshiyuki Shiraki, Shinji Kondo, Mari Nakamura, Daisuke Sasaki, Takahiro Arakawa, Jun Kawai, Matthias Harbers, Yoshihide Hayashizaki1 and Piero Carninci Nature Methods1, 233–239
(December 2004); doi:10.1038/nmeth719
| Abstract | Full Text (HTML/PDF) |
letters to nature The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
Ryan T. Phan and Riccardo Dalla-Favera Nature432, 635–639
(02 December 2004); doi:10.1038/nature03147
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
Chaowei Wu, Irene Miloslavskaya, Silvia Demontis, Roberta Maestro and Konstantin Galaktionov Nature432, 640–645
(02 December 2004); doi:10.1038/nature03173
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review article The role of the unfolded protein response in tumour development: friend or foe?
Yanjun Ma and Linda M. Hendershot Nature Reviews Cancer4, 966–977
(December 2004); doi:10.1038/nrc1505
| Summary | Full Text (HTML / PDF) |
review article Netrin-1 and its receptors in tumorigenesis
Hirofumi Arakawa Nature Reviews Cancer4, 978–987
(December 2004); doi:10.1038/nrc1504
| Summary | Full Text (HTML / PDF) |
November
review article Why do cancers have high aerobic glycolysis?
Robert A. Gatenby and Robert J. Gillies Nature Reviews Cancer4, 891–899
(November 2004); doi:10.1038/nrc1478
| Abstract | Full Text (HTML / PDF) |
article PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein
Matthew J Daniels, Alexander Marson and Ashok R Venkitaraman Nature Structural and Molecular Biology11, 1114–1121
(November 2004); doi:10.1038/nsmb837
| Abstract | Full Text (HTML/PDF) |
review article Friends or foes — bipolar effects of the tumour stroma in cancer
Margareta M. Mueller and Norbert E. Fusenig Nature Reviews Cancer4, 839–849
(November 2004); doi:10.1038/nrc1477
| Abstract | Full Text (HTML / PDF) |
review article The RAF proteins take centre stage
Claudia Wellbrock, Maria Karasarides and Richard Marais Nature Reviews Molecular Cell Biology5, 875–885
(November 2004); doi:10.1038/nrm1498
| Abstract | Full Text (HTML / PDF) |
letter The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
Kwai Wa Cheng, John P Lahad, Wen-lin Kuo, Anna Lapuk, Kyosuke Yamada, Nelly Auersperg, Jinsong Liu, Karen Smith-McCune, Karen H Lu, David Fishman, Joe W Gray and Gordon B Mills Nature Medicine10, 1251–1256
(November 2004); doi:10.1038/nm1125
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technical report Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
Lene Uhrbom, Edward Nerio and Eric C Holland Nature Medicine10, 1257–1260
(November 2004); doi:10.1038/nm1120
| Abstract | Full Text (HTML/PDF) |
review article The emerging roles of human tissue kallikreins in cancer
Carla A. Borgoño and Eleftherios P. Diamandis Nature Reviews Cancer4, 876–890
(November 2004); doi:10.1038/nrc1474
| Abstract | Full Text (HTML / PDF) |
brief communication Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
Andrzej Ptasznik, Yuji Nakata, Anna Kalota, Stephen G Emerson and Alan M. Gewirtz Nature Medicine10, 1187–1189
(November 2004); doi:10.1038/nm1127
| First Paragraph | Full Text (HTML/PDF) |
review article Antitumour effects of antiretroviral therapy
Paolo Monini, Cecilia Sgadari, Elena Toschi, Giovanni Barillari and Barbara Ensoli Nature Reviews Cancer4, 861–875
(November 2004); doi:10.1038/nrc1479
| Abstract | Full Text (HTML / PDF) |
brief communication Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
Sandra Hanks, Kim Coleman, Sarah Reid, Alberto Plaja, Helen Firth, David FitzPatrick, Alexa Kidd, Károly Méhes, Richard Nash, Nathanial Robin, Nora Shannon, John Tolmie, John Swansbury, Alexandre Irrthum, Jenny Douglas and Nazneen Rahman Nature Genetics36, 1159–1161
(November 2004); doi:10.1038/ng1449
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news and views From spindle checkpoint to cancer
Christoph Lengauer and Zhenghe Wang Nature Genetics36, 1144–1145
(November 2004); doi:10.1038/ng1104-1144
| Full Text (HTML/PDF) |
October
letters to nature MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Catherine M. Shachaf, Andrew M. Kopelman, Constadina Arvanitis, Åsa Karlsson, Shelly Beer, Stefanie Mandl, Michael H. Bachmann, Alexander D. Borowsky, Boris Ruebner, Robert D. Cardiff, Qiwei Yang, J. Michael Bishop, Christopher H. Contag and Dean W. Felsher Nature431, 1112–1117
(28 October 2004); doi:10.1038/nature03043
| First Paragraph | Full Text (HTML / PDF) |
review article High interstitial fluid pressure — an obstacle in cancer therapy
Carl-Henrik Heldin, Kristofer Rubin, Kristian Pietras and Arne Östman Nature Reviews Cancer4, 806–813
(October 2004); doi:10.1038/nrc1456
| Abstract | Full Text (HTML / PDF) |
news and views Cancer: Negative feedback for B cells
Louis M. Staudt
The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated. Nature431, 919–920
(21 October 2004); doi:10.1038/431919a
| Full Text (HTML / PDF) |
article Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
Binhua P. Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M. Li, Mehmet Gunduz and Mien-Chie Hung Nature Cell Biology6, 931–940
(October 2004); doi:10.1038/ncb1173
| Abstract | Full Text (HTML/PDF) |
news and views GSK-3β sets Snail's pace
Karni Schlessinger and Alan Hall Nature Cell Biology6, 913–915
(October 2004); doi:10.1038/ncb1004-913
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review article Epstein-Barr virus: 40 years on
Lawrence S. Young and Alan B. Rickinson Nature Reviews Cancer4, 757–768
(October 2004); doi:10.1038/nrc1452
| Abstract | Full Text (HTML / PDF) |
article Identification of BRCA1-IRIS, a BRCA1 locus product
Wael M. ElShamy and David M. Livingston Nature Cell Biology6, 954–967
(October 2004); doi:10.1038/ncb1171
| Abstract | Full Text (HTML/PDF) |
news and views Refocusing on BRCA1
Alan Ashworth Nature Cell Biology6, 916–917
(October 2004); doi:10.1038/ncb1004-916
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review article Polyamines and cancer: old molecules, new understanding
Eugene W. Gerner and Frank L. Meyskens Jr Nature Reviews Cancer4, 781–792
(January 2004); doi:10.1038/nrc1454
| Abstract | Full Text (HTML / PDF) |
letter Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
C. Graux, J. Cools, C. Melotte, H. Quentmeier, A. Ferrando, R. Levine, J.R. Vermeesch, M. Stul, B. Dutta, N. Boeckx, A. Bosly, P. Heimann, A. Uyttebroeck, N. Mentens, R. Somers, R.A.F. MacLeod, H.G. Drexler, A.T. Look, D.G. Gilliland, L. Michaux, P. Vandenberghe, I. Wlodarska, Peter Marynen and Anne Hagemeijer Nature Genetics36, 1084–1089
(October 2004); doi:10.1038/ng1425
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review article Genetic predisposition to cancer — insights from population genetics
Steven A. Frank Nature Reviews Genetics5, 764–772
(October 2004); doi:10.1038/nrg1450
| Abstract | Full Text (HTML / PDF) |
letters to nature Hedgehog signalling in prostate regeneration, neoplasia and metastasis
Sunil S. Karhadkar, G. Steven Bova , Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T. Isaacs, David M. Berman and Philip A. Beachy Nature431, 707–712
(07 October 2004); doi:10.1038/nature02962
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technical report Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis
Fabian Kiessling, Susanne Greschus, Matthias P Lichy, Michael Bock, Christian Fink, Silvia Vosseler, Jens Moll, Margareta M Mueller, Norbert E. Fusenig, Horst Traupe and Wolfhard Semmler Nature Medicine10, 1133–1138
(October 2004); doi:10.1038/nm1101
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review article Genetic predisposition to colorectal cancer
Albert de la Chapelle Nature Reviews Cancer4, 769–780
(October 2004); doi:10.1038/nrc1453
| Abstract | Full Text (HTML / PDF) |
review article Post-translational modification of p53 in tumorigenesis
Ann M. Bode and Zigang Dong Nature Reviews Cancer4, 793–805
(October 2004); doi:10.1038/nrc1455
| Abstract | Full Text (HTML / PDF) |
letter A module map showing conditional activity of expression modules in cancer
Eran Segal, Nir Friedman, Daphne Koller and Aviv Regev Nature Genetics36, 1090–1098
(October 2004); doi:10.1038/ng1434
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brief communication Lung cancer: Intragenic ERBB2 kinase mutations in tumours
Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S. Cooper, Adrienne M. Flanagan, Margaret Knowles, Suet Y. Leung, David N. Louis, Leendert H. J. Looijenga, Bruce Malkowicz, Marco A. Pierotti, Bin Teh, Georgia Chenevix-Trench, Barbara L. Weber, Siu T. Yuen, Grace Harris, Peter Goldstraw, Andrew G. Nicholson, P. Andrew Futreal, Richard Wooster and Michael R. Stratton Nature431, 525–526
(30 September 2004); doi:10.1038/431525b
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review article Integrin signalling during tumour progression
Wenjun Guo and Filippo G. Giancotti Nature Reviews Molecular Cell Biology5, 816–826
(October 2004); doi:10.1038/nrm1490
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perspectives Opinion: Hallmarks of 'BRCAness' in sporadic cancers
Nicholas Turner, Andrew Tutt and Alan Ashworth Nature Reviews Cancer4, 814–819
(October 2004); doi:10.1038/nrc1457
| Abstract | Full Text (HTML / PDF) |
letter BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
Xi C He, Jiwang Zhang, Wei-Gang Tong, Ossama Tawfik, Jason Ross, David H Scoville, Qiang Tian, Xin Zeng, Xi He, Leanne M Wiedemann, Yuji Mishina and Linheng Li Nature Genetics36, 1117–1121
(October 2004); doi:10.1038/ng1430
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news and views Linking pathways in colorectal cancer
Gijs R van den Brink Nature Genetics36, 1038–1039
(October 2004); doi:10.1038/ng1004-1038
| Full Text (HTML/PDF) |
review article Genetic predisposition to cancer — insights from population genetics
Steven A. Frank Nature Reviews Genetics5, 764–772
(October 2004); doi:10.1038/nrg1450
| Abstract | Full Text (HTML / PDF) |
September
letters to nature NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky, Rinnat M. Porat, Ilan Stein , Rinat Abramovitch, Sharon Amit, Shafika Kasem, Elena Gutkovich-Pyest, Simcha Urieli-Shoval, Eithan Galun and Yinon Ben-Neriah Nature431, 461–466
(23 September 2004); doi:10.1038/nature02924
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news and views Cancer: An inflammatory link
Fran Balkwill and Lisa M. Coussens Nature431, 405–406
(23 September 2004); doi:10.1038/431405a
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article Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Tyler J Curiel, George Coukos, Linhua Zou, Xavier Alvarez, Pui Cheng, Peter Mottram, Melina Evdemon-Hogan, Jose R Conejo-Garcia, Lin Zhang, Matthew Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, Ben Daniel, Alan Gordon, Leann Myers, Andrew Lackner, Mary L Disis, Keith L Knutson, Lieping Chen and Weiping Zou Nature Medicine10, 942–949
(September 2004); doi:10.1038/nm1093
| Abstract | Full Text (HTML/PDF) |
news and views Fatal attraction: tumors beckon regulatory T cells
Ethan M Shevach Nature Medicine10, 900–901
(September 2004); doi:10.1038/nm0904-900
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article Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A
Jose R Conejo-Garcia, Fabian Benencia, Maria-Cecilia Courreges, Eugene Kang, Alisha Mohamed-Hadley, Ronald J Buckanovich, David O Holtz, Ann Jenkins, Hana Na, Lin Zhang, Daniel S Wagner, Dionyssios Katsaros, Richard Caroll and George Coukos Nature Medicine10, 950–958
(September 2004); doi:10.1038/nm1097
| Abstract | Full Text (HTML/PDF) |
review article Oncogenic mechanisms of the Helicobacter pylori CagA protein
Masanori Hatakeyama Nature Reviews Cancer4, 688–694
(September 2004); doi:10.1038/nrc1433
| Abstract | Full Text (HTML / PDF) |
review article Gallbladder cancer: lessons from a rare tumour
Ignacio I. Wistuba and Adi F. Gazdar Nature Reviews Cancer4, 695–706
(September 2004); doi:10.1038/nrc1429
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Transcription — guarding the genome by sensing DNA damage
Mats Ljungman and David P. Lane Nature Reviews Cancer4, 727–737
(September 2004); doi:10.1038/nrc1435
| Abstract | Full Text (HTML / PDF) |
news and views From mRNA to tumor suppressor
Dan Mercola and John Welsh Nature Genetics36, 937–938
(September 2004); doi:10.1038/ng0904-937
| Full Text (HTML/PDF) |
technical report Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
Evelyn B Voura, Jyoti K Jaiswal, Hedi Mattoussi and Sanford M Simon Nature Medicine10, 993–998
(September 2004); doi:10.1038/nm1096
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review article Gene-promoter hypermethylation as a biomarker in lung cancer
Steven A. Belinsky Nature Reviews Cancer4, 707–717
(September 2004); doi:10.1038/nrc1432
| Abstract | Full Text (HTML / PDF) |
letters to nature Cytoplasmic PML function in TGF-β signalling
Hui-Kuan Lin, Stephan Bergmann and Pier Paolo Pandolfi Nature431, 205–211
(09 September 2004); doi:10.1038/nature02783
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news and views Cell biology: An unexpected social servant
Christine Le Roy and Jeffrey L. Wrana Nature431, 142
(09 September 2004); doi:10.1038/431142a
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news and views Spindle checkpoint protein links Rb pathway to aneuploidy
Bernd Pulverer Nature Cell Biology6, 806
(September 2004); doi:10.1038/ncb0904-806
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brief communication The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Héctor G Pálmer, María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros and Alberto Muñoz Nature Medicine10, 917–919
(September 2004); doi:10.1038/nm1095
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review article BRCA1 and BRCA2: 1994 and beyond
Steven A. Narod and William D. Foulkes Nature Reviews Cancer4, 665–676
(September 2004); doi:10.1038/nrc1431
| Abstract | Full Text (HTML / PDF) |
review article WNT and β-catenin signalling: diseases and therapies
Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari and Ajamete Kaykas Nature Reviews Genetics5, 691–701
(September 2004); doi:10.1038/nrg1427
| Abstract | Full Text (HTML / PDF) |
research article A simple method to cure established tumors by inflammatory killing of normal cells
Gregory A Daniels, Luis Sanchez-Perez, Rosa Maria Diaz, Timothy Kottke, Jill Thompson, Maoyi Lai, Michael Gough, Mahzuz Karim, Andrew Bushell, Heung Chong, Alan Melcher, Kevin Harrington and Richard G Vile Nature Biotechnology22, 1125–1132
(September 2004); doi:10.1038/nbt1007
| Abstract | Full Text (HTML/PDF) |
news and views Immunotherapy dispenses with tumor antigens
Soldano Ferrone Nature Biotechnology22, 1096–1098
(September 2004); doi:10.1038/nbt0904-1096
| Full Text (HTML/PDF) |
letters to nature Netrin–1 controls colorectal tumorigenesis by regulating apoptosis
Laetitia Mazelin, Agnès Bernet, Christelle Bonod–Bidaud, Laurent Pays, Ségolène Arnaud, Christian Gespach, Dale E Bredesen, Jean–Yves Scoazec and Patrick Mehlen Nature431, 80–84
(02 September 2004); doi:10.1038/nature02788
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news and views Cancer: Cell survival guide
Eric R. Fearon and Kathleen R. Cho Nature431, 35–36
(02 September 2004); doi:10.1038/431035a
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perspectives Opinion: Switching on kinases: oncogenic activation of BRAF and the PDGFR family
Nick J. Dibb, Stephen M. Dilworth and Clifford D. Mol Nature Reviews Cancer4, 718–727
(September 2004); doi:10.1038/nrc1434
| Summary | Full Text (HTML / PDF) |
letter Nonsense–mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
Pia Huusko, Damaris Ponciano–Jackson, Maija Wolf, Jeff A Kiefer, David O Azorsa, Sukru Tuzmen, Don Weaver, Christiane Robbins, Tracy Moses, Minna Allinen, Sampsa Hautaniemi, Yidong Chen, Abdel Elkahloun, Mark Basik, G Steven Bova, Lukas Bubendorf, Alessandro Lugli, Guido Sauter, Johanna Schleutker, Hilmi Ozcelik, Sabine Elowe, Tony Pawson, Jeffrey M Trent, John D Carpten, Olli–P Kallioniemi and Spyro Mousses Nature Genetics36, 979–983
(September 2004); doi:10.1038/ng1408
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August
letters to nature Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
Sirith Douma, Theo van Laar, John Zevenhoven, Ralph Meuwissen, Evert van Garderen and Daniel S. Peeper Nature430, 1034–1039
(26 August 2004); doi:10.1038/nature02765
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news and views Anoikis: Cancer and the homeless cell
Lance A. Liotta and Elise Kohn Nature430, 973–974
(26 August 2004); doi:10.1038/430973a
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letter MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
Deborah N. Chadee and John M. Kyriakis Nature Cell Biology6, 770–776
(August 2004); doi:10.1038/ncb1152
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review article Biologically active sphingolipids in cancer pathogenesis and treatment
Besim Ogretmen and Yusuf A. Hannun Nature Reviews Cancer4, 604–616
(August 2004); doi:10.1038/nrc1411
| Summary | Full Text (HTML / PDF) |
research article In vivo cancer targeting and imaging with semiconductor quantum dots
Xiaohu Gao, Yuanyuan Cui, Richard M Levenson, Leland W K Chung and Shuming Nie Nature Biotechnology22, 969–976
(August 2004); doi:10.1038/nbt994
| Abstract | Full Text (HTML/PDF) |
news and views Zooming in and out with quantum dots
Rakesh K Jain and Mark Stroh Nature Biotechnology22, 959–960
(August 2004); doi:10.1038/nbt0804-959
| Full Text (HTML/PDF) |
article Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
Toshiyuki Araki, M Golam Mohi, Fraz A Ismat, Roderick T Bronson, Ifor R Williams, Jeffery L Kutok, Wentian Yang, Lily I Pao, D Gary Gilliland, Jonathan A Epstein and Benjamin G Neel Nature Medicine10, 849–857
(August 2004); doi:10.1038/nm1084
| Abstract | Full Text (HTML/PDF) |
historical perspective Cancer genes and the pathways they control
Bert Vogelstein and Kenneth W Kinzler Nature Medicine10, 789–799
(August 2004); doi:10.1038/nm1087
| Abstract | Full Text (HTML/PDF) |
review article Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle and Rudolf Kaaks Nature Reviews Cancer4, 579–591
(August 2004); doi:10.1038/nrc1408
| Summary | Full Text (HTML / PDF) |
letters to nature Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
Eva Hernando, Zaher Nahlé , Gloria Juan, Elena Diaz-Rodriguez, Miguel Alaminos, Michael Hemann, Loren Michel, Vivek Mittal, William Gerald, Robert Benezra, Scott W. Lowe and Carlos Cordon-Cardo Nature430, 797–802
(12 August 2004); doi:10.1038/nature02820
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article SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
Ryuji Hamamoto, Yoichi Furukawa, Masashi Morita, Yuko Iimura, Fabio Pittella Silva, Meihua Li, Ryuichiro Yagyu and Yusuke Nakamura Nature Cell Biology6, 731–740
(August 2004); doi:10.1038/ncb1151
| Abstract | Full Text (HTML/PDF) |
news and views From chromatin to cancer: a new histone lysine methyltransferase enters the mix
Robert J. Sims 3rd and Danny Reinberg Nature Cell Biology6, 685–687
(August 2004); doi:10.1038/ncb0804-685
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perspectives Opinion: Inflammation and necrosis promote tumour growth
Jukka Vakkila and Michael T. Lotze Nature Reviews Immunology4, 641–648
(August 2004); doi:10.1038/nri1415
| Summary | Full Text (HTML / PDF) |
review article Pathways of apoptotic and non-apoptotic death in tumour cells
Hitoshi Okada and Tak W. Mak Nature Reviews Cancer4, 592–603
(August 2004); doi:10.1038/nrc1412
| Summary | Full Text (HTML / PDF) |
news and views TGFβ signaling in health and disease
Rosemary J Akhurst Nature Genetics36, 790–792
(August 2004); doi:10.1038/ng0804-790
| Full Text (HTML/PDF) |
perspectives Opinion: Integrated global profiling of cancer
Samir Hanash Nature Reviews Cancer4, 638–644
(August 2004); doi:10.1038/nrc1414
| Abstract | Full Text (HTML / PDF) |
July
article Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
Kristin J Hope, Liqing Jin and John E Dick Nature Immunology5, 738–743
(July 2004); doi:10.1038/ni1080
| Abstract | Full Text (HTML/PDF) |
news and views Cancer stem cells refined
David T Scadden Nature Immunology5, 701–703
(July 2004); doi:10.1038/ni0704-701
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review article Hyaluronan: from extracellular glue to pericellular cue
Bryan P. Toole Nature Reviews Cancer4, 528–539
(July 2004); doi:10.1038/nrc1391
| Abstract | Full Text (HTML / PDF) |
letter PML regulates p53 stability by sequestering Mdm2 to the nucleolus
Rosa Bernardi, Pier Paolo Scaglioni, Stephan Bergmann, Henning F. Horn, Karen H. Vousden and Pier Paolo Pandolfi Nature Cell Biology6, 665–672
(July 2004); doi:10.1038/ncb1147
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review article Insulin-like growth factors and neoplasia
Michael N. Pollak, Eva S. Schernhammer and Susan E. Hankinson Nature Reviews Cancer4, 505–518
(July 2004); doi:10.1038/nrc1387
| Abstract | Full Text (HTML / PDF) |
letters to nature Cyclin-dependent kinases regulate the antiproliferative function of Smads
Isao Matsuura , Natalia G. Denissova , Guannan Wang , Dongming He , Jianyin Long and Fang Liu Nature430, 226–231
(08 July 2004); doi:10.1038/nature02650
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perspectives Opinion: Analysis of genomic targets reveals complex functions of MYC
Jagruti H. Patel, Andrey P. Loboda, Michael K. Showe, Louise C. Showe and Steven B. McMahon Nature Reviews Cancer4, 562–568
(July 2004); doi:10.1038/nrc1393
| Abstract | Full Text (HTML / PDF) |
news and views Cancer: Understanding the target
M R Stratton & P A Futreal Nature430, 30
(01 July 2004); doi:10.1038/nrm1423
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review article Cancer and the chemokine network
Fran Balkwill Nature Reviews Cancer4, 540–550
(July 2004); doi:10.1038/nrc1388
| Abstract | Full Text (HTML / PDF) |
June
review article Exploiting tumour hypoxia in cancer treatment
J. Martin Brown and William R. Wilson Nature Reviews Cancer4, 437–447
(June 2004); doi:10.1038/nrc1367
| Abstract | Full Text (HTML / PDF) |
review article Dissecting the metastatic cascade
Klaus Pantel and Ruud H. Brakenhoff Nature Reviews Cancer4, 448–456
(June 2004); doi:10.1038/nrc1370
| Abstract | Full Text (HTML / PDF) |
letter Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
Frank Rosenbauer, Katharina Wagner, Jeffery L Kutok, Hiromi Iwasaki, Michelle M Le Beau, Yutaka Okuno, Koichi Akashi, Steven Fiering and Daniel G Tenen Nature Genetics36, 624–630
(June 2004); doi:10.1038/ng1361
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news and views Fine-tuning PU.1
Derek L Stirewalt Nature Genetics36, 550–551
(June 2004); doi:10.1038/ng0604-550
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article Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
R Scott Williams, Megan S Lee, D Duong Hau and J N Mark Glover Nature Structural and Molecular Biology11, 519–525
(June 2004); doi:10.1038/nsmb776
| Abstract | Full Text (HTML/PDF) |
review article The anti-angiogenic basis of metronomic chemotherapy
Robert S. Kerbel and Barton A. Kamen Nature Reviews Cancer4, 423–436
(June 2004); doi:10.1038/nrc1369
| Abstract | Full Text (HTML / PDF) |
article Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Julie A Clapperton, Isaac A Manke, Drew M Lowery, Timmy Ho, Lesley F Haire, Michael B Yaffe and Stephen J Smerdon Nature Structural and Molecular Biology11, 512–518
(June 2004); doi:10.1038/nsmb775
| Abstract | Full Text (HTML/PDF) |
article Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
R Scott Williams, Megan S Lee, D Duong Hau & J N Mark Glover Nature Structural and Molecular Biology11, 519–525
(June 2004); doi:10.1038/nsmb776
| Abstract | Full Text (HTML/PDF) |
article Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy
Phil Oh, Yan Li, Jingyi Yu, Eberhard Durr, Karolina M. Krasinska, Lucy A. Carver, Jacqueline E. Testa and Jan E. Schnitzer Nature429, 629–635
(10 June 2004); doi:10.1038/nature02580
| Abstract | Full Text (HTML / PDF) |
news and views Molecular medicine: The writing is on the vessel wall
Christopher H. Contag and Michael H. Bachmann Nature429, 618–619
(10 June 2004); doi:10.1038/429618a
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article Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness
Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan W. Henning, Gerald Beste, Bradley T. Scroggins, Len Neckers, Leodevico L. Ilag and Daniel G. Jay Nature Cell Biology6, 507–514
(June 2004); doi:10.1038/ncb1131
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news and views Hsp90 invades the outside
Didier Picard Nature Cell Biology6, 479–480
(June 2004); doi:10.1038/ncb0604-479
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article mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane and William R Sellers Nature Medicine10, 594–601
(June 2004); doi:10.1038/nm1052
| Abstract | Full Text (HTML/PDF) |
news and views TORward AKTually useful mouse models
Ingo K Mellinghoff and Charles L Sawyers Nature Medicine10, 579–580
(June 2004); doi:10.1038/nm0604-579
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review article A renaissance for SRC
Timothy J. Yeatman Nature Reviews Cancer4, 470–480
(June 2004); doi:10.1038/nrc1366
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Yeast as a model system for anticancer drug discovery
Julian A. Simon and Antonio Bedalov Nature Reviews Cancer4, 481– 487
(June 2004); doi:10.1038/nrc1372
| Abstract | Full Text (HTML / PDF) |
review article Targeted therapy for brain tumours
Maciej S. Lesniak and Henry Brem Nature Reviews Drug Discovery3, 499–508
(June 2004); doi:10.1038/nrd1414
| Abstract | Full Text (HTML / PDF) |
May
letters to nature An autonomous molecular computer for logical control of gene expression
Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar and Ehud Shapiro Nature429, 423–429
(27 May 2004); doi:10.1038/nature02551
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news and views Automata make antisense
Anne Condon Nature429, 351–352
(27 May 2004); doi:10.1038/429351a
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brief communication The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Paola Londei, Carlos Cordon-Cardo and Pier Paolo Pandolfi Nature Medicine10, 484–486
(May 2004); doi:10.1038/nm1042
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review article Molecules and mechanisms of the graft-versus-leukaemia effect
Marie Bleakley and Stanley R. Riddell Nature Reviews Cancer4, 371–380
(May 2004); doi:10.1038/nrc1365
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review article C/EBPα mutations in acute myeloid leukaemias
Claus Nerlov Nature Reviews Cancer4, 394–400
(May 2004); doi:10.1038/nrc1363
| Abstract | Full Text (HTML / PDF) |
article Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
Yiguo Hu, Yuhua Liu, Shawn Pelletier, Elisabeth Buchdunger, Markus Warmuth, Doriano Fabbro, Michael Hallek, Richard A Van Etten and Shaoguang Li Nature Genetics36, 453–461
(May 2004); doi:10.1038/ng1343
| Abstract | Full Text (HTML/PDF) |
news and views Src kinases in Ph+ lymphoblastic leukemia
Michael Deininger Nature Genetics36, 440–441
(May 2004); doi:10.1038/ng0504-440
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review article Searching for the hereditary causes of renal-cell carcinoma
Christian P. Pavlovich and Laura S. Schmidt Nature Reviews Cancer4, 381–393
(May 2004); doi:10.1038/nrc1364
| Abstract | Full Text (HTML / PDF) |
perspectives Timeline: The discovery of receptor tyrosine kinases: targets for cancer therapy
Andreas Gschwind, Oliver M. Fischer and Axel Ullrich Nature Reviews Cancer4, 361–370
(May 2004); doi:10.1038/nrc1360
| Abstract | Full Text (HTML / PDF) |
review article The TOR pathway: a target for cancer therapy
Mary-Ann Bjornsti and Peter J. Houghton Nature Reviews Cancer4, 335–348
(May 2004); doi:10.1038/nrc1362
| Abstract | Full Text (HTML / PDF) |
brief communication Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis
Fred S Harman, Christopher J Nicol, Holly E Marin, Jerrold M Ward, Frank J Gonzalez and Jeffrey M Peters Nature Medicine10, 481–483
(May 2004); doi:10.1038/nm1026
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review article The proteasome: a suitable antineoplastic target
Julian Adams Nature Reviews Cancer4, 349–360
(May 2004); doi:10.1038/nrc1361
| Abstract | Full Text (HTML / PDF) |
April
review article Molecular targets in pituitary tumours
Anthony P. Heaney and Shlomo Melmed Nature Reviews Cancer4, 285–295
(April 2004); doi:10.1038/nrc1320
| Abstract | Full Text (HTML / PDF) |
perspectives Timeline: The evolution of thalidomide and its IMiD derivatives as anticancer agents
J. Blake Bartlett, Keith Dredge and Angus G. Dalgleish Nature Reviews Cancer4, 314–322
(April 2004); doi:10.1038/nrc1323
| Abstract | Full Text (HTML / PDF) |
news and views Cancer: Enzymes play molecular tag
Deborah K. Morrison Nature428, 813–815
(22 April 2004); doi:10.1038/428813a
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review article Tracing the network connecting brca and fanconi anaemia proteins
Ashok R. Venkitaraman Nature Reviews Cancer4, 266–276
(April 2004); doi:10.1038/nrc1321
| Abstract | Full Text (HTML / PDF) |
brief communication A receptor for green tea polyphenol EGCG
Hirofumi Tachibana, Kiyoshi Koga, Yoshinori Fujimura and Koji Yamada Nature Structural and Molecular Biology11, 380–381
(April 2004); doi:10.1038/nsmb743
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news and views Cancer: Kip moving
John G. Collard Nature428, 705–708
(15 April 2004); doi:10.1038/428705a
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article A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
Elizabeth Yeh, Melissa Cunningham, Hugh Arnold, Dawn Chasse, Teresa Monteith, Giovanni Ivaldi, William C. Hahn, P. Todd Stukenberg, Shirish Shenolikar, Takafumi Uchida, Christopher M. Counter, Joseph R. Nevins, Anthony R. Means and Rosalie Sears Nature Cell Biology6, 308–318
(April 2004); doi:10.1038/ncb1110
| Abstract | Full Text (HTML/PDF) |
news and views PINning down the c-Myc oncoprotein
David Dominguez-Sola and Riccardo Dalla-Favera Nature Cell Biology6, 288–289
(April 2004); doi:10.1038/ncb0404-288
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review article The pathobiology of mucositis
Stephen T. Sonis Nature Reviews Cancer4, 277–284
(April 2004); doi:10.1038/nrc1318
| Abstract | Full Text (HTML / PDF) |
news and views Shutting down Wnt signal-activated cancer
M Mark Taketo Nature Genetics36, 320–322
(April 2004); doi:10.1038/ng0404-320
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news and views Cell biology: Competitive edge
Amanda Tromans Nature428, 609
(08 April 2004); doi:10.1038/428609a
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article CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer
Zhongmin Guo, Jürgen F. Linn, Guojun Wu, Sarah L Anzick, Claus F Eisenberger, Sarel Halachmi, Yoram Cohen, Alexey Fomenkov, Mohammad Obaidul Hoque, Kenji Okami, Gabriel Steiner, James M Engles, Motonabu Osada, Chulso Moon, Edward Ratovitski, Jeffrey M Trent, Paul S Meltzer, William H Westra, Lambertus A Kiemeney, Mark P Schoenberg, David Sidransky and Barry Trink Nature Medicine10, 374–381
(April 2004); doi:10.1038/nm1010
| Abstract | Full Text (HTML/PDF) |
perspectives Opinion: Rules of evidence for cancer molecular-marker discovery and validation
David F. Ransohoff Nature Reviews Cancer4, 309–314
(April 2004); doi:10.1038/nrc1322
| Abstract | Full Text (HTML / PDF) |
article Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway
Dmitry V Bulavin, Crissy Phillips, Bonnie Nannenga, Oleg Timofeev, Larry A Donehower, Carl W Anderson, Ettore Appella and Albert J Fornace Jr. Nature Genetics36, 343–350
(April 2004); doi:10.1038/ng1317
| Abstract | Full Text (HTML/PDF) |
news and views Wip-ing out cancer
René Bernards Nature Genetics36, 319–320
(April 2004); doi:10.1038/ng0404-319
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news and views Cancer's sphere of influence
Charlotte Schubert Nature Medicine10, 349
(April 2004); doi:10.1038/nm0404-349
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review article Microtubules as a target for anticancer drugs
Mary Ann Jordan and Leslie Wilson Nature Reviews Cancer4, 253–265
(April 2004); doi:10.1038/nrc1317
| Abstract | Full Text (HTML / PDF) |
letter Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Hiromu Suzuki, D Neil Watkins, Kam-Wing Jair, Kornel E Schuebel, Sanford D Markowitz, Wei Dong Chen, Theresa P Pretlow, Bin Yang, Yoshimitsu Akiyama, Manon van Engeland, Minoru Toyota, Takashi Tokino, Yuji Hinoda, Kohzoh Imai, James G Herman and Stephen B Baylin Nature Genetics36, 417–422
(April 2004); doi:10.1038/ng1330
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March
news and views Medicine: Profile of a tumour
Olli Kallioniemi Nature428, 379–382
(25 March 2004); doi:10.1038/428379b
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review article A census of human cancer genes
P. Andrew Futreal, Lachlan Coin, Mhairi Marshall, Thomas Down, Timothy Hubbard, Richard Wooster, Nazneen Rahman and Michael R. Stratton Nature Reviews Cancer4, 177–183
(March 2004); doi:10.1038/nrc1299
| Abstract | Full Text (HTML / PDF) |
letter Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation
Kimberly Stegmaier, Kenneth N Ross, Sierra A Colavito, Shawn O'Malley, Brent R Stockwell and Todd R Golub Nature Genetics36, 257–263
(March 2004); doi:10.1038/ng1305
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news and views Gene expression as a drug discovery tool
William E Evans and R Kip Guy Nature Genetics36, 214–215
(March 2004); doi:10.1038/ng0304-214
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letters to nature The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
Igor Garkavtsev, Sergey V. Kozin, Olga Chernova, Lei Xu, Frank Winkler, Edward Brown, Gene H. Barnett and Rakesh K. Jain Nature428, 328–332
(18 March 2004); doi:10.1038/nature02329
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letters to nature Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
Hans-Guido Wendel, Elisa de Stanchina, Jordan S. Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier and Scott W. Lowe Nature428, 332–337
(18 March 2004); doi:10.1038/nature02369
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news and views Cancer: Survival pathways meet their end
Frank McCormick Nature428, 267–269
(18 March 2004); doi:10.1038/428267a
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letters to nature Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
Carly Leung, Merel Lingbeek, Olga Shakhova, James Liu, Ellen Tanger, Parvin Saremaslani, Maarten van Lohuizen and Silvia Marino Nature428, 337–341
(18 March 2004); doi:10.1038/nature02385
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news and views Cancer: Dangerous liaisons
Allan Balmain and Rosemary J. Akhurst Nature428, 271–272
(18 March 2004); doi:10.1038/428271a
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article VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Elizabeth A Harrington, David Bebbington, Jeff Moore, Richele K Rasmussen, Abi O Ajose-Adeogun, Tomoko Nakayama, Joanne A Graham, Cecile Demur, Thierry Hercend, Anita Diu-Hercend, Michael Su, Julian M C Golec and Karen M Miller Nature Medicine10, 262–267
(March 2004); doi:10.1038/nm1003
| Abstract | Full Text (HTML/PDF) |
news and views Aurora kinases dawn as cancer drug targets
Edward A Sausville Nature Medicine10, 234–235
(March 2004); doi:10.1038/nm0304-234
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perspectives Opinion: Cancer as a robust system: implications for anticancer therapy
Hiroaki Kitano Nature Reviews Cancer4, 227–235
(March 2004); doi:10.1038/nrc1300
| Abstract | Full Text (HTML / PDF) |
review article Targeting the checkpoint kinases: chemosensitization versus chemoprotection
Bin-Bing S. Zhou and Jiri Bartek Nature Reviews Cancer4, 216–225
(March 2004); doi:10.1038/nrc1296
| Abstract | Full Text (HTML / PDF) |
letter Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
Gijs R van den Brink, Sylvia A Bleuming, James C H Hardwick, Berber L Schepman, G Johan Offerhaus, Josbert J Keller, Corinne Nielsen, William Gaffield, Sander J H van Deventer, Drucilla J Roberts & Maikel P Peppelenbosch Nature Genetics36, 277–282
(March 2004); doi:10.1038/ng1304
| Abstract | Full Text (HTML/PDF) |
letters to nature Inactivation of hCDC4 can cause chromosomal instability
Harith Rajagopalan, Prasad V. Jallepalli, Carlo Rago, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein and Christoph Lengauer Nature428, 77–81
(04 March 2004); doi:10.1038/nature02313
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letters to nature A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
Sathees C. Raghavan, Patrick C. Swanson, Xiantuo Wu, Chih-Lin Hsieh and Michael R. Lieber Nature428, 88–93
(04 March 2004); doi:10.1038/nature02355
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news and views Molecular biology: Case of mistaken identity
Craig H. Bassing and Frederick W. Alt Nature428, 29–31
(04 March 2004); doi:10.1038/428029a
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article Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
Ronit Satchi-Fainaro, Mark Puder, John W Davies, Hai T Tran, David A Sampson, Arin K Greene, Gabriel Corfas and Judah Folkman Nature Medicine10, 255–261
(March 2004); doi:10.1038/nm1002
| Abstract | Full Text (HTML/PDF) |
brief communication Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-d accelerates intestinal adenoma growth
Rajnish A Gupta, Dingzhi Wang, Sharada Katkuri, Haibin Wang, Sudhansu K Dey and Raymond N DuBois Nature Medicine10, 245–247
(March 2004); doi:10.1038/nm993
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news and views Fragile fugue: p53 in aging, cancer and IGF signaling
Judith Campisi Nature Medicine10, 231–232
(March 2004); doi:10.1038/nm0304-231
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review article Tumour-suppressor function in the nervous system
Suzanne J. Baker and Peter J. McKinnon Nature Reviews Cancer4, 184–196
(March 2004); doi:10.1038/nrc1297
| Abstract | Full Text (HTML / PDF) |
February
news and views Turning the key on p53
David P. Lane and Peter M. Fischer Nature427, 789–790
(26 February 2004); doi:10.1038/427789a
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perspectives Opinion: Radiation-induced bystander effects — implications for cancer
Colin B. Seymour and Carmel Mothersill Nature Reviews Cancer4, 158–164
(February 2004); doi:10.1038/nrc1277
| Abstract | Full Text (HTML / PDF) |
brief communication Pathology: Cancer cells compress intratumour vessels
Timothy P. Padera, Brian R. Stoll, Jessica B. Tooredman, Diane Capen, Emmanuelle di Tomaso and Rakesh K. Jain Nature427, 695
(19 February 2004); doi:10.1038/427695a
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letter The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex
Min Sup Song, Su Jeong Song, Nagi G. Ayad, Jin Sook Chang, Joo Hyun Lee, Hyun Kyung Hong, Ho Lee, Naeyun Choi, Jhingook Kim, Hojoong Kim, Jin Woo Kim, Eui-Ju Choi, Marc W. Kirschner and Dae-Sik Lim Nature Cell Biology6, 129–137
(February 2004); doi:10.1038/ncb1091
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article Priming of naive T cells inside tumors leads to eradication of established tumors
Ping Yu, Youjin Lee, Wenhua Liu, Robert K Chin, Jing Wang, Yang Wang, Andrea Schietinger, Mary Philip, Hans Schreiber and Yang-Xin Fu Nature Immunology5, 141–149
(February 2004); doi:10.1038/ni1029
| Abstract | Full Text (HTML/PDF) |
news and views LIGHTing the way for tumor immunity
Alan N Houghton Nature Immunology5, 123–124
(February 2004); doi:10.1038/ni0204-123
| Full Text (HTML/PDF) |
article Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
Yanlin Yu, Javed Khan, Chand Khanna, Lee Helman, Paul S Meltzer and Glenn Merlino Nature Medicine10, 175–181
(February 2004); doi:10.1038/nm966
| Abstract | Full Text (HTML/PDF) |
review article Nuclear transport and cancer: from mechanism to intervention
Tweeny R. Kau , Jeffrey C. Way and Pamela A. Silver Nature Reviews Cancer4, 106–117
(February 2004); doi:10.1038/nrc1274
| Abstract | Full Text (HTML / PDF) |
news and views EMSY, a BRCA-2 partner in crime
David M Livingston Nature Medicine10, 127–128
(February 2004); doi:10.1038/nm0204-127
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review article The STATs of cancer — new molecular targets come of age
Hua Yu and Richard Jove Nature Reviews Cancer4, 97–105
(February 2004); doi:10.1038/nrc1275
| Abstract | Full Text (HTML / PDF) |
article Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor
Christine C Milburn, Jérôme Boudeau, Maria Deak, Dario R Alessi and Daan M F van Aalten Nature Structural and Molecular Biology11, 193–200
(February 2004); doi:10.1038/nsmb716
| Abstract | Full Text (HTML/PDF) |
new and views Creating new peptide antigens by slicing and splicing proteins
Victor H Engelhard Nature Immunology5, 128–129
(February 2004); doi:10.1038/ni0204-128
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letter The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
Chand Khanna, Xiaolin Wan, Seuli Bose, Ryan Cassaday, Osarenoma Olomu, Arnulfo Mendoza, Choh Yeung, Richard Gorlick, Stephen M Hewitt and Lee J Helman Nature Medicine10, 182–186
(February 2004); doi:10.1038/nm982
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brief communication Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
Christopher G Willett, Yves Boucher, Emmanuelle di Tomaso, Dan G Duda, Lance L Munn, Ricky T Tong, Daniel C Chung, Dushyant V Sahani, Sanjeeva P Kalva, Sergey V Kozin, Mari Mino, Kenneth S Cohen, David T Scadden, Alan C Hartford, Alan J Fischman, Jeffrey W Clark, David P Ryan, Andrew X Zhu, Lawrence S Blaszkowsky, Helen X Chen, Paul C Shellito, Gregory Y Lauwers and Rakesh K Jain Nature Medicine10, 145–147
(February 2004); doi:10.1038/nm988
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review article Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
Ugo Cavallaro and Gerhard Christofori Nature Reviews Cancer4, 118–132
(February 2004); doi:10.1038/nrc1276
| Abstract | Full Text (HTML / PDF) |
letter Dynamics of the p53-Mdm2 feedback loop in individual cells
Galit Lahav, Nitzan Rosenfeld, Alex Sigal, Naama Geva-Zatorsky, Arnold J Levine, Michael B Elowitz and Uri Alon Nature Genetics36, 147–150
(February 2004); doi:10.1038/ng1293
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news and views Monitoring p53's pulse
John J Tyson Nature Genetics36, 113–114
(February 2004); doi:10.1038/ng0204-113
| Full Text (HTML/PDF) |
January
article Molecular determinants of resistance to antiandrogen therapy
Charlie D Chen, Derek S Welsbie, Chris Tran, Sung Hee Baek, Randy Chen, Robert Vessella, Michael G Rosenfeld and Charles L Sawyers Nature Medicine10, 33–39
(January 2004); doi:10.1038/nm972
| Abstract | Full Text (HTML/PDF) |
news and views Androgen receptor outwits prostate cancer drugs
John T Isaacs and William B Isaacs Nature Medicine10, 26–27
(January 2004); doi:10.1038/nm0104-26
| Full Text (HTML/PDF) |
review article Mucins in cancer: protection and control of the cell surface
Michael A. Hollingsworth and Benjamin J. Swanson Nature Reviews Cancer4, 45–60
(January 2004); doi:10.1038/nrc1251
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Impact of race/ethnicity on molecular pathways in human cancer
John K. Wiencke Nature Reviews Cancer4, 79–84
(January 2004); doi:10.1038/nrc1257
| Abstract | Full Text (HTML / PDF) |
review article Peroxisome-proliferator-activated receptors and cancers: complex stories
Liliane Michalik, Béatrice Desvergne and Walter Wahli Nature Reviews Cancer4, 61–70
(January 2004); doi:10.1038/nrc1254
| Summary | Full Text (HTML / PDF) |
letters to nature Immune recognition of a human renal cancer antigen through post-translational protein splicing
Ken-ichi Hanada, Jonathan W. Yewdell and James C. Yang Nature427, 252–256
(15 January 2004); doi:10.1038/nature02240
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news and views Immunology: Protein surgery
Hans-Georg Rammensee Nature427, 203–204
(15 January 2004); doi:10.1038/427203a
| Full Text (HTML / PDF) |
letters to nature Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
Sharon A. Matheny, Chiyuan Chen, Robert L. Kortum, Gina L. Razidlo, Robert E. Lewis and Michael A. White Nature427, 256–260
(15 January 2004); doi:10.1038/nature02237
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letter Polycomb CBX7 has a unifying role in cellular lifespan
Jesús Gil, David Bernard, Dolores Martínez and David Beach Nature Cell Biology6, 67–72
(January 2004); doi:10.1038/ncb1077
| First Paragraph | Full Text (HTML/PDF) |
article Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya, Kenneth Shain, Shumin Zhang, Raka Bhattacharya, Dmitry Gabrilovich, Richard Heller, Domenico Coppola, William Dalton, Richard Jove, Drew Pardoll and Hua Yu Nature Medicine10, 48–54
(January 2004); doi:10.1038/nm976
| Abstract | Full Text (HTML/PDF) |
review article Cytokines in cancer pathogenesis and cancer therapy
Glenn Dranoff Nature Reviews Cancer4, 11–22
(January 2004); doi:10.1038/nrc1252
| Abstract | Full Text (HTML / PDF) |
article Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai, Zhi-Min Yuan, Jolanta Bondaruk, Fumio Suzuki, Satoshi Fujii, Ralph B Arlinghaus, Bogdan A Czerniak and Subrata Sen Nature Genetics36, 55–62
(January 2004); doi:10.1038/ng1279
| Abstract | Full Text (HTML/PDF) |
letter Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
Geng Liu, John M Parant, Gene Lang, Patty Chau, Arturo Chavez-Reyes, Adel K El-Naggar, Asha Multani, Sandy Chang and Guillermina Lozano
Nature Genetics36, 63–68
(January 2004); doi:10.1038/ng1282
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news and views Conquering the complexity of p53
Laura D Attardi and Ronald A DePinho Nature Genetics36, 7–8
(January 2004); doi:10.1038/ng0104-7
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news and views Cancer: Guarding the guardian?
Henning F. Horn and Karen H. Vousden Nature427, 110–111
(08 January 2004); doi:10.1038/427110a
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article Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, Kelly Mihalic, Ying-Xin Fan, Weihua Xiao, O M Zack Howard, Ettore Appella, Andrew T Maynard and William L Farrar Nature Medicine10, 40–47
(January 2004); doi:10.1038/nm969
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review article Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling
G. Tim Bowden Nature Reviews Cancer4, 23–35
(January 2004); doi:10.1038/nrc1253
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news and views E3 ligase activity and suppression of breast cancer
Angela K Eggleston Nature Structural & Molecular Biology11, 8–9
(January 2004); doi:10.1038/nsmb0104-8
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