Review article Oncogenic PI3K deregulates transcription and translation
Andreas G. Bader, Sohye Kang, Li Zhao and Peter K. Vogt Nature Reviews Cancer5, 921–929
(December 2005); doi:10.1038/nrc1753
| Summary | Full Text (HTML / PDF) |
article Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun and Yongfeng Shang Nature438, 981–987
(15 December 2005); doi:10.1038/nature04225
| Summary | Full Text (HTML / PDF) |
letter R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis
Masanobu Komatsu and Erkki Ruoslahti Nature Medicine11, 1346–1350
(December 2005); doi:10.1038/nm1324
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review article A role for Kaiso-p120ctn complexes in cancer?
Frans M. van Roy and Pierre D. McCrea Nature Reviews Cancer5, 956–964
(December 2005); doi:10.1038/nrc1752
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article VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan , Rebecca D. Riba , Stergios Zacharoulis , Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan Wu, Jeffrey L. Port, Nasser Altorki, Elisa R. Port, Davide Ruggero, Sergey V. Shmelkov, Kristian K. Jensen, Shahin Rafii and David Lyden Nature438, 820–827
(08 December 2005); doi:10.1038/nature04186
| Summary | Full Text (HTML / PDF) |
news and views Cancer biology: Emissaries set up new sites
Patricia S. Steeg Nature438, 750–751
(08 December 2005); doi:10.1038/438750b
| Full Text (HTML / PDF) |
article Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
Marcin Kortylewski, Maciej Kujawski, Tianhong Wang, Sheng Wei, Shumin Zhang, Shari Pilon-Thomas, Guilian Niu, Heidi Kay, James Mulé, William G Kerr, Richard Jove, Drew Pardoll and Hua Yu Nature Medicine11, 1314–1321
(December 2005); doi:10.1038/nm1325
| Abstract | Full Text (HTML/PDF) |
review article Statins and cancer prevention
Marie-France Demierre , Peter D. R. Higgins , Stephen B. Gruber, Ernest Hawk and Scott M. Lippman Nature Reviews Cancer5, 930–942
(December 2005); doi:10.1038/nrc1751
| Summary | Full Text (HTML / PDF) |
brief communication Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
Daphne W Bell, Ira Gore, Ross A Okimoto, Nadia Godin-Heymann, Raffaella Sordella, Roseann Mulloy, Sreenath V Sharma, Brian W Brannigan, Gayatry Mohapatra, Jeff Settleman and Daniel A Haber Nature Genetics37, 1315–1316
(December 2005); doi:10.1038/ng1671
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review article Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Bryan T. Hennessy, Debra L. Smith, Prahlad T. Ram, Yiling Lu and Gordon B. Mills Nature Reviews Drug Discovery4, 988–1004
(December 2005); doi:10.1038/nrd1902
| Summary | Full Text (HTML / PDF) |
November
review article Lysosomes and autophagy in cell death control
Guido Kroemer and Marja Jäättelä Nature Reviews Cancer5, 886–897
(November 2005); doi:10.1038/nrc1738
| Summary | Full Text (HTML / PDF) |
review article Promoting apoptosis as a strategy for cancer drug discovery
Stephen W. Fesik Nature Reviews Cancer5, 876–885
(November 2005); doi:10.1038/nrc1736
| Summary | Full Text (HTML / PDF) |
review article Mitochondrial tumour suppressors: a genetic and biochemical update
Eyal Gottlieb and Ian P. M. Tomlinson Nature Reviews Cancer5, 857–866
(November 2005); doi:10.1038/nrc1737
| Abstract | Full Text (HTML / PDF) |
technical report Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
Ross A Dickins, Michael T Hemann, Jack T Zilfou, David R Simpson, Ingrid Ibarra, Gregory J Hannon and Scott W Lowe Nature Genetics37, 1289–1295
(November 2005); doi:10.1038/ng1651
| Abstract
| Full Text (HTML / PDF) |
October
review article The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
Rosa A. Cardone, Valeria Casavola and Stephan J. Reshkin Nature Reviews Cancer5, 786–795
(27 October 2005); doi:10.1038/nrc1713
| Summary | Full Text (HTML / PDF) |
article XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
Purificación Muñoz, Raquel Blanco, Juana M Flores and María A Blasco Nature Genetics37, 1063–1071
(October 2005); doi:10.1038/ng1633
| Abstract | Full Text (HTML/PDF) |
letter Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
Takeshi Fujiwara, Madhavi Bandi, Masayuki Nitta, Elena V. Ivanova, Roderick T. Bronson and David Pellman Nature437, 1043–1047
(13 October 2005); doi:10.1038/nature04217
| First Paragraph | Full Text (HTML / PDF) |
article Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells
Caroline Cole, Jian Qiao, Timothy Kottke, Rosa Maria Diaz, Atique Ahmed, Luis Sanchez-Perez, Gregory Brunn, Jill Thompson, John Chester and Richard G Vile Nature Medicine11, 1073–1081
(October 2005); doi:10.1038/nm1297
| Abstract | Full Text (HTML/PDF) |
news and views Hitchhiker's guide to the T cell
Cliona M Rooney Nature Medicine11, 1051–1052
(October 2005); doi:10.1038/nm1005-1051
| Full Text (HTML/PDF) |
review article The multiple uses of fluorescent proteins to visualize cancer in vivo
Robert M. Hoffman Nature Reviews Cancer5, 796–806
(October 2005); doi:10.1038/nrc1717
| Abstract | Full Text (HTML / PDF) |
review article NF-κB: linking inflammation and immunity to cancer development and progression
Michael Karin and Florian R. Greten Nature Reviews Immunology5, 749–759
(October 2005); doi:10.1038/nri1703
| Abstract | Full Text (HTML / PDF) |
news and views Stem cells, asymmetric division and cancer
Hans Clevers Nature Genetics37, 1027–1028
(October 2005); doi:10.1038/ng1005-1027
| Full Text (HTML/PDF) |
September
review article The role of autophagy in cancer development and response to therapy
Yasuko Kondo, Takao Kanzawa , Raymond Sawaya and Seiji Kondo Nature Reviews Cancer5, 726–734
(September 2005); doi:10.1038/nrc1692
| Abstract | Full Text (HTML / PDF) |
letter Clusterin inhibits apoptosis by interacting with activated Bax
Honglai Zhang, Jin Koo Kim, Chris A. Edwards, Zhaohui Xu, Russell Taichman and Cun-Yu Wang Nature Cell Biology7, 909–915
(September 2005); doi:10.1038/ncb1291
| First Paragraph | Full Text (HTML/PDF) |
article Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
David E Oppenheim, Scott J Roberts, Sarah L Clarke, Renata Filler, Julie M Lewis, Robert E Tigelaar, Michael Girardi and Adrian C Hayday Nature Immunology6, 928–937
(September 2005); doi:10.1038/ni1239
| Abstract | Full Text (HTML/PDF) |
letter Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells
Yusuke Mizukami, Won-Seok Jo, Eva-Maria Duerr, Manish Gala, Jingnan Li, Xiaobo Zhang, Michael A Zimmer, Othon Iliopoulos, Lawrence R Zukerberg, Yutaka Kohgo, Maureen P Lynch, Bo R Rueda and Daniel C Chung Nature Medicine11, 992–997
(September 2005); doi:10.1038/nm1294
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review article Urothelial tumorigenesis: a tale of divergent pathways
Xue-Ru Wu Nature Reviews Cancer5, 713–725
(September 2005); doi:10.1038/nrc1697
| Abstract | Full Text (HTML / PDF) |
letter The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
Wendy L Bridge, Cassandra J Vandenberg, Roger J Franklin and Kevin Hiom Nature Genetics37, 953–957
(September 2005); doi:10.1038/ng1627
| First Paragraph | Full Text (HTML/PDF) |
letter A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
Amom Ruhikanta Meetei, Annette L Medhurst, Chen Ling, Yutong Xue, Thiyam Ramsing Singh, Patrick Bier, Jurgen Steltenpool, Stacie Stone, Inderjeet Dokal, Christopher G Mathew, Maureen Hoatlin, Hans Joenje, Johan P de Winter and Weidong Wang Nature Genetics37, 958–963
(September 2005); doi:10.1038/ng1626
| First Paragraph | Full Text (HTML/PDF) |
letter Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
Abdolrahman S. Nateri, Bradley Spencer-Dene and Axel Behrens Nature437, 281–285
(08 September 2005); doi:10.1038/nature03914
| First Paragraph | Full Text (HTML / PDF) |
August
letter Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
Gerald Willimsky and Thomas Blankenstein Nature437, 141–146
(01 September 2005); doi:10.1038/nature03954
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letter Role of nucleophosmin in embryonic development and tumorigenesis
Silvia Grisendi, Rosa Bernardi, Marco Rossi, Ke Cheng, Luipa Khandker, Katia Manova and Pier Paolo Pandolfi Nature437, 147–153
(01 September 2005); doi:10.1038/nature03915
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review article Breast cancer metastasis: markers and models
Britta Weigelt, Johannes L. Peterse and Laura J. van't Veer Nature Reviews Cancer5, 591–602
(August 2005); doi:10.1038/nrc1670
| Abstract | Full Text (HTML / PDF) |
letter Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation
Angela H Ting, Kornel E Schuebel, James G Herman and Stephen B Baylin Nature Genetics37, 906–910
(August 2005); doi:10.1038/ng1611
| First Paragraph | Full Text (HTML/PDF) |
letter Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis
Michael A Ko, Carla O Rosario, John W Hudson, Sarang Kulkarni, Aaron Pollett, James W Dennis and Carol J Swallow Nature Genetics37 883–888
(2005); doi:10.1038/ng1605/
| First paragraph | Full Text (HTML/PDF) |
review article Using Drosophila melanogaster to map human cancer pathways
Anthony M. Brumby and Helena E. Richardson Nature Reviews Cancer5, 626–639
(August 2005); doi:10.1038/nrc1671
| Abstract | Full Text (HTML / PDF) |
article Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
Michael T. Hemann, Anka Bric, Julie Teruya-Feldstein, Andreas Herbst, Jonas A. Nilsson, Carlos Cordon-Cardo, John L. Cleveland, William P. Tansey and Scott W. Lowe Nature436, 807–811
(11 August 2005); doi:10.1038/nature03845
| Abstract | Full Text (HTML / PDF) |
news and views Cancer: Two in one
Anton Berns Nature436, 787–789
(11 August 2005); doi:10.1038/436787a
| Full Text (HTML / PDF) |
letter Identification of JAK/STAT signalling components by genome-wide RNA interference
Patrick Müller, David Kuttenkeuler, Viola Gesellchen, Martin P. Zeidler and Michael Boutros Nature436, 871–875
(11 August 2005); doi:10.1038/nature03869
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brief communication Colorectal cancer: Mutations in a signalling pathway
D. Williams Parsons, Tian-Li Wang, Yardena Samuels, Alberto Bardelli, Jordan M. Cummins, Laura DeLong, Natalie Silliman, Janine Ptak, Steve Szabo, James K. V. Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer and Victor E. Velculescu Nature436, 792
(11 August 2005); doi:10.1038/436792a
| First Paragraph | Full Text (HTML / PDF) |
review article Telomeres and human disease: ageing, cancer and beyond
Maria A. Blasco Nature Reviews Genetics6, 611–622
(August 2005); doi:10.1038/nrg1656
| Abstract | Full Text (HTML / PDF) |
article Oncogene-induced senescence as an initial barrier in lymphoma development
Melanie Braig, Soyoung Lee, Christoph Loddenkemper, Cornelia Rudolph, Antoine H.F.M. Peters, Brigitte Schlegelberger, Harald Stein, Bernd Dörken, Thomas Jenuwein and Clemens A. Schmitt Nature436, 660–665
(04 August 2005); doi:10.1038/nature03841
| Abstract | Full Text (HTML / PDF) |
letter Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Zhenbang Chen, Lloyd C. Trotman, David Shaffer, Hui-Kuan Lin, Zohar A. Dotan, Masaru Niki, Jason A. Koutcher, Howard I. Scher, Thomas Ludwig, William Gerald, Carlos Cordon-Cardo and Pier Paolo Pandolfi Nature436, 725–730
(04 August 2005); doi:10.1038/nature03918
| First Paragraph | Full Text (HTML / PDF) |
brief communications Tumour biology: Senescence in premalignant tumours
Manuel Collado, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J. Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M. Flores, Mariano Barbacid, David Beach and Manuel Serrano Nature436, 642
(04 August 2005); doi:10.1038/436642a
| First Paragraph | Full Text (HTML / PDF) |
news and views Cancer: Crime and punishment
Norman E. Sharpless and Ronald A. DePinho Nature436, 636–637
(04 August 2005); doi:10.1038/436636a
| Full Text (HTML / PDF) |
review article Id family of helix-loop-helix proteins in cancer
Jonathan Perk, Antonio Iavarone and Robert Benezra Nature Reviews Cancer5, 603–614
(August 2005); doi:10.1038/nrc1673
| Abstract | Full Text (HTML / PDF) |
article Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
Michael Weber, Jonathan J Davies, David Wittig, Edward J Oakeley, Michael Haase, Wan L Lam and Dirk Schübeler Nature Genetics37, 853–862
(August 2005); doi:10.1038/ng1598
| Abstract | Full Text (HTML/PDF) |
July
article Genes that mediate breast cancer metastasis to lung
Andy J. Minn , Gaorav P. Gupta, Peter M. Siegel, Paula D. Bos, Weiping Shu, Dilip D. Giri, Agnes Viale, Adam B. Olshen, William L. Gerald and Joan Massagué Nature436, 518–524
(28 July 2005); doi:10.1038/nature03799
| Abstract | Full Text (HTML / PDF) |
news and views Cancer: One step at a time
David Mooney Nature436, 468–469
(28 July 2005); doi:10.1038/436468a
| Full Text (HTML / PDF) |
article A critical function for type I interferons in cancer immunoediting
Gavin P Dunn, Allen T Bruce, Kathleen C F Sheehan, Vijay Shankaran, Ravindra Uppaluri, Jack D Bui, Mark S Diamond, Catherine M Koebel, Cora Arthur, J Michael White and Robert D Schreiber Nature Immunology6, 722–729
(July 2005); doi:10.1038/ni1213
| Abstract | Full Text (HTML/PDF) |
news and views Type I interferon and cancer immunoediting
Mark J Smyth Nature Immunology6, 646–648
(July 2005); doi:10.1038/ni0705-646
| Full Text (HTML/PDF) |
review article The anaemia of
cancer: death by a thousand cuts Jerry L. Spivak Nature Reviews
Cancer5, 543–555 (July 2005); doi:10.1038/nrc1648 | Abstract | Full Text (HTML /
PDF) |
review article The role of focal-adhesion kinase in cancer — a new therapeutic opportunity
Gordon W. McLean, Neil O. Carragher, Egle Avizienyte, Jeff Evans, Valerie G. Brunton and Margaret C. Frame Nature Reviews Cancer5, 505–515
(July 2005); doi:10.1038/nrc1647
| Summary | Full Text (HTML / PDF) |
news and views Cancer biology: The weakest link?
Glenn Merlino Nature436, 33–35
(07 July 2005); doi:10.1038/436033a
| Full Text (HTML / PDF) |
letter Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
Derek C. Radisky, Dinah D. Levy, Laurie E. Littlepage, Hong Liu, Celeste M. Nelson, Jimmie E. Fata, Devin Leake, Elizabeth L. Godden, Donna G. Albertson, M. Angela Nieto, Zena Werb and Mina J. Bissell Nature436, 123–127
(07 July 2005); doi:10.1038/nature03688
| First Paragraph | Full Text (HTML / PDF) |
June
article Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
Roberto Chiarle, William J Simmons, Honjying Cai, Girish Dhall, Alberto Zamo, Regina Raz, James G Karras, David E Levy and Giorgio Inghirami Nature Medicine11, 623–629
(June 2005); doi:10.1038/nm1249
| Abstract | Full Text (HTML/PDF) |
news and views Validating Stat3 in cancer therapy
James E Darnell Jr Nature Medicine11, 595–596
(June 2005); doi:10.1038/nm0605-595
| Full Text (HTML/PDF) |
letter Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
Johan H. van Es, Marielle E. van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J. Winton, Freddy Radtke and Hans Clevers Nature435, 959–963
(16 June 2005); doi:10.1038/nature03659
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review article Disrupting tumour blood vessels
Gillian M. Tozer, Chryso Kanthou and Bruce C. Baguley Nature Reviews Cancer5, 423–435
(June 2005); doi:10.1038/nrc1628
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letter A microRNA polycistron as a potential human oncogene
Lin He, J. Michael Thomson, Michael T. Hemann, Eva Hernando-Monge, David Mu, Summer Goodson, Scott Powers, Carlos Cordon-Cardo, Scott W. Lowe, Gregory J. Hannon and Scott M. Hammond Nature435, 828–833
(09 June 2005); doi:10.1038/nature03552
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letter MicroRNA expression profiles classify human cancers
Jun Lu , Gad Getz, Eric A. Miska , Ezequiel Alvarez-Saavedra, Justin Lamb, David Peck, Alejandro Sweet-Cordero, Benjamin L. Ebert, Raymond H. Mak, Adolfo A. Ferrando, James R. Downing, Tyler Jacks, H. Robert Horvitz and Todd R. Golub Nature435, 834–838
(09 June 2005); doi:10.1038/nature03702
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news and views Cancer genomics: Small RNAs with big impacts
Paul S. Meltzer Nature435, 745–746
(09 June 2005); doi:10.1038/435745a
| Full Text (HTML / PDF) |
review article Glycans in cancer and inflammation — potential for therapeutics and diagnostics
Danielle H. Dube and Carolyn R. Bertozzi Nature Reviews Drug Discovery4, 477–488
(June 2005); doi:10.1038/nrd1751
| Summary | Full Text (HTML / PDF) |
letter An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Tilman Oltersdorf , Steven W. Elmore , Alexander R. Shoemaker , Robert C. Armstrong , David J. Augeri , Barbara A. Belli , Milan Bruncko , Thomas L. Deckwerth , Jurgen Dinges , Philip J. Hajduk , Mary K. Joseph , Shinichi Kitada , Stanley J. Korsmeyer , Aaron R. Kunzer , Anthony Letai , Chi Li , Michael J. Mitten , David G. Nettesheim , ShiChung Ng , Paul M. Nimmer , Jacqueline M. O'Connor , Anatol Oleksijew , Andrew M. Petros , John C. Reed , Wang Shen , Stephen K. Tahir , Craig B. Thompson , Kevin J. Tomaselli , Baole Wang , Michael D. Wendt , Haichao Zhang , Stephen W. Fesik and Saul H. Rosenberg Nature435, 677–681
(02 June 2005); doi:10.1038/nature03579
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brief communication A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens, Sarah O'Meara, Adrian Parker, Patrick Tarpey, Tim Avis, Andy Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Anthony Green, Maggie Knowles, Suet Y Leung, Leendert H J Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin Teh, Siu T Yuen, Andrew G Nicholson, Sunil Lakhani, Douglas F Easton, Barbara L Weber, Michael R Stratton, P Andrew Futreal and Richard Wooster Nature Genetics37, 590–592
(June 2005); doi:10.1038/ng1571
| First Paragraph | Full Text (HTML/PDF) |
analysis Mining for regulatory programs in the cancer transcriptome
Daniel R Rhodes, Shanker Kalyana-Sundaram, Vasudeva Mahavisno, Terrence R Barrette, Debashis Ghosh and Arul M Chinnaiyan Nature Genetics37, 579–583
(June 2005); doi:10.1038/ng1578
| Abstract | Full Text (HTML/PDF) |
May
article Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
Wenjun Cheng, Jinsong Liu, Hiroyuki Yoshida, Daniel Rosen and Honami Naora Nature Medicine11, 531–537
(May 2005); doi:10.1038/nm1230
| Abstract | Full Text (HTML/PDF) |
review article The RUNX genes: gain or loss of function in cancer
Karen Blyth, Ewan R. Cameron and James C. Neil Nature Reviews Cancer5, 376–387
(2005) doi:10.1038/nrc1607
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review article Regulators of apoptosis: suitable targets for immune therapy of cancer
Mads Hald Andersen , Jürgen C. Becker and Per thor Straten Nature Reviews Drug Discovery4, 399–409
(May 2005); doi:10.1038/nrd1717
| Summary | Full Text (HTML / PDF) |
news and views An Achilles' heel for breast cancer?
Keith W Caldecott and Anthony Chalmers Nature Structural and Molecular Biology12, 387–388
(May 2005); doi:10.1038/nsmb0505-387
| Full Text (HTML/PDF) |
perspectives Phosphorylation-specific prolyl isomerization: is there an underlying theme?
Gerburg Wulf, Greg Finn, Futoshi Suizu and Kun Ping Lu Nature Cell Biology7, 435–441
(May 2005); doi:10.1038/ncb0505-435
| Abstract | Full Text (HTML/PDF) |
review article ERBB receptors and cancer: the complexity of targeted inhibitors
Nancy E. Hynes and Heidi A. Lane Nature Reviews Cancer5, 341–354
(May 2005); doi:10.1038/nrc1609
| Summary | Full Text (HTML / PDF) |
April
letters to nature A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James, Valérie Ugo, Jean-Pierre Le Couédic, Judith Staerk, François Delhommeau, Catherine Lacout, Loïc Garçon, Hana Raslova, Roland Berger, Annelise Bennaceur-Griscelli, Jean Luc Villeval, Stefan N.Constantinescu, Nicole Casadevall and William Vainchenker Nature434, 1144–1148
(28 April 2005); doi:10.1038/nature03546
| First Paragraph | Full Text (HTML / PDF) |
letter Chfr is required for tumor suppression and Aurora A regulation
Xiaochun Yu, Katherine Minter-Dykhouse, Liviu Malureanu, Wei-Meng Zhao, Dongwei Zhang, Carolin J Merkle, Irene M Ward, Hideyuki Saya, Guowei Fang, Jan van Deursen and Junjie Chen Nature Genetics37, 401–406
(April 2005); doi:10.1038/ng1538
| First Paragraph | Full Text (HTML/PDF) |
letter Wnt signalling induces maturation of Paneth cells in intestinal crypts
Johan H. van Es, Philippe Jay, Alex Gregorieff, Marielle E. van Gijn, Suzanne Jonkheer, Pantelis Hatzis, Andrea Thiele, Maaike van den Born, Harry Begthel, Thomas Brabletz, Makoto M. Taketo and Hans Clevers Nature Cell Biology7, 381–386
(April 2005); doi:10.1038/ncb1240
| First Paragraph | Full Text (HTML/PDF) |
letter Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
Susana Gonzalo, Marta García-Cao, Mario F. Fraga, Gunnar Schotta, Antoine H.F.M. Peters, Shane E. Cotter, Raúl Eguía, Douglas C. Dean, Manel Esteller, Thomas Jenuwein and María A. Blasco Nature Cell Biology7, 420–428
(April 2005); doi:10.1038/ncb1235
| First Paragraph | Full Text (HTML/PDF) |
review article Immunosuppressive networks in the tumour environment and their therapeutic relevance
Weiping Zou Nature Reviews Cancer5, 263–274
(April 2005); doi:10.1038/nrc1586
| Summary | Full Text (HTML / PDF) |
article DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jirina Bartkova, Zuzana Hoejí, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas and Jiri Bartek Nature434, 864–870
(14 April 2005); doi:10.1038/nature03482
| Summary | Full Text (HTML / PDF) |
news and views Medicine: Aborting the birth of cancer
Ashok R. Venkitaraman Nature434, 829–830
(14 April 2005); doi:10.1038/434829a
| Full Text (HTML / PDF) |
letters to nature Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant, Niklas Schultz, Huw D. Thomas, Kayan M. Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J. Curtin and Thomas Helleday Nature434, 913–917
(14 April 2005); doi:10.1038/nature03443
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Hannah Farmer , Nuala McCabe , Christopher J. Lord, Andrew N. J. Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M. B. Martin, Stephen P. Jackson, Graeme C. M. Smith and Alan Ashworth Nature434, 917–921
(14 April 2005); doi:10.1038/nature03445
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes
Jung Hwa Kim, Bogyou Kim, Ling Cai, Hee June Choi, Kenneth A. Ohgi, Chris Tran, Charlie Chen, Chin Ha Chung, Otmar Huber, David W. Rose, Charles L. Sawyers, Michael G. Rosenfeld and Sung Hee Baek Nature434, 921–926
(14 April 2005); doi:10.1038/nature03452
| First Paragraph | Full Text (HTML / PDF) |
review article Wnt signalling in stem cells and cancer
Tannishtha Reya and Hans Clevers Nature434, 843–850
(14 April 2005); doi:10.1038/nature03319
| Summary | Full Text (HTML / PDF) |
review article Mechanisms of B-cell lymphoma pathogenesis
Ralf Küppers Nature Reviews Cancer5, 251–262
(April 2005); doi:10.1038/nrc1589
| Summary | Full Text (HTML / PDF) |
perspectives Timeline: Leukaemia stem cells and the evolution of cancer-stem-cell research
Brian J. P. Huntly and D. Gary Gilliland Nature Reviews Cancer5, 311–321
(April 2005); doi:10.1038/nrc1592
| Summary | Full Text (HTML / PDF) |
article CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
Fumiko Esashi, Nicole Christ, Julian Gannon, Yilun Liu, Tim Hunt, Maria Jasin and Stephen C. West Nature434, 598–604
(31 March 2005); doi:10.1038/nature03404
| Summary | Full Text (HTML / PDF) |
review article The promise of genetically engineered mice for cancer prevention studies
Jeffrey E. Green and Tamaro Hudson Nature Reviews Cancer5, 184–198
(March 2005); doi:10.1038/nrc1565
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March
article G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
Mutsuo Harada, Yingjie Qin, Hiroyuki Takano, Tohru Minamino, Yunzeng Zou, Haruhiro Toko, Masashi Ohtsuka, Katsuhisa Matsuura, Masanori Sano, Jun-ichiro Nishi, Koji Iwanaga, Hiroshi Akazawa, Takeshige Kunieda, Weidong Zhu, Hiroshi Hasegawa, Keita Kunisada, Toshio Nagai, Haruaki Nakaya, Keiko Yamauchi-Takihara and Issei Komuro Nature Medicine11, 305–311
(March 2005); doi:10.1038/nm1199
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article Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
Alexander J Muller, James B DuHadaway, P Scott Donover, Erika Sutanto-Ward and George C Prendergast Nature Medicine11, 312–319
(March 2005); doi:10.1038/nm1196
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review article Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
Ruibao Ren Nature Reviews Cancer5, 172–183
(March 2005); doi:10.1038/nrc1567
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article Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
Harikrishnan K N, Maggie Z Chow, Emma K Baker, Sharmistha Pal, Sahar Bassal, Daniella Brasacchio, Li Wang, Jeff M Craig, Peter L Jones, Saïd Sif and Assam El-Osta Nature Genetics37, 254–264
(March 2005); doi:10.1038/ng1516
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news and views SWItching off methylated DNA
Paul A Wade Nature Genetics37, 212–213
(March 2005); doi:10.1038/ng0305-212
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letters to nature The MET oncogene drives a genetic programme linking cancer to haemostasis
Carla Boccaccio, Gabriella Sabatino, Enzo Medico, Flavia Girolami, Antonia Follenzi, Gigliola Reato, Antonino Sottile, Luigi Naldini and Paolo M. Comoglio Nature434, 396–400
(17 March 2005); doi:10.1038/nature03357
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letter Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
Savraj S. Grewal, Ling Li, Amir Orian, Robert N. Eisenman and Bruce A. Edgar Nature Cell Biology7, 295–302
(March 2005); doi:10.1038/ncb1223
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letter c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt, Lars-Gunnar Larsson and Anthony P. H. Wright Nature Cell Biology7, 303–310
(March 2005); doi:10.1038/ncb1225
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letter c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
Carla Grandori, Natividad Gomez-Roman, Zoe A. Felton-Edkins, Celine Ngouenet, Denise A. Galloway, Robert N. Eisenman and Robert J. White Nature Cell Biology7, 311–318
(March 2005); doi:10.1038/ncb1224
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news and views The Myc trilogy: lord of RNA polymerases
Thordur Oskarsson and Andreas Trumpp Nature Cell Biology7, 215–217
(March 2005); doi:10.1038/ncb0305-215
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article Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia
Randall E Burton, Tania A Baker and Robert T Sauer Oncogene
(AOP 28 February 2005); doi:10.1038/c
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February
letter An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
Paul Roepman, Lodewyk F A Wessels, Nienke Kettelarij, Patrick Kemmeren, Antony J Miles, Philip Lijnzaad, Marcel G J Tilanus, Ronald Koole, Gert-Jan Hordijk, Peter C van der Vliet, Marcel J T Reinders, Piet J Slootweg and Frank C P Holstege Nature Genetics37, 182–186
(February 2005); doi:10.1038/ng1502
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review article Close encounters of different kinds: Dendritic cells and NK cells take centre stage
Mariapia A. Degli-Esposti and Mark J. Smyth Nature Reviews Immunology5, 112–124
(February 2005); doi:10.1038/nri1549
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letters to nature The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
Haijuan Yang, Qiubai Li, Jie Fan, William K. Holloman and Nikola P. Pavletich Nature433, 653–657
(10 February 2005); doi:10.1038/nature03234
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news and views Cancer: Catalyst of a catalyst
Stephen C. Kowalczykowski Nature433, 591–592
(10 February 2005); doi:10.1038/433591a
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review article Bleomycins: towards better therapeutics
Jingyang Chen and JoAnne Stubbe Nature Reviews Cancer5, 102–112
(February 2005); doi:10.1038/nrc1547
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January
review article RNA polymerases I and III, growth control and cancer
Robert J. White Nature Reviews Molecular Cell Biology6, 69–78
(January 2005); doi:10.1038/nrm1551
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news and views Inflammation and cancer: the long reach of Ras
Michael Karin Nature Medicine11, 20–21
(January 2005); doi:10.1038/nm0105-20
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review article Integrin-linked kinase: a cancer therapeutic target unique among its ILK
Gregory Hannigan, Armelle A. Troussard and Shoukat Dedhar Nature Reviews Cancer5, 51–63
(January 2005); doi:10.1038/nrc1524
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article Role of the proto-oncogene Pokemon in cellular transformation and ARF repression
Takahiro Maeda, Robin M. Hobbs, Taha Merghoub, Ilhem Guernah, Arthur Zelent, Carlos Cordon-Cardo, Julie Teruya-Feldstein and Pier Paolo Pandolfi Nature433, 278–285
(20 January 2005); doi:10.1038/nature03203
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review article Aurora-A — A guardian of poles
Tomotoshi Marumoto, Dongwei Zhang and Hideyuki Saya Nature Reviews Cancer5, 42–50
(January 2005); doi:10.1038/nrc1526
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research article FGF-20 and DKK1 are transcriptional targets of β-catenin and FGF-20 is implicated in cancer and development
Mario N Chamorro, Donald R Schwartz, Alin Vonica, Ali H Brivanlou, Kathleen R Cho and Harold E Varmus EMBO Journal24, 73–84
(January 2005); doi:10.1038/sj.emboj.7600460
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letter Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
Alessandra Insinga, Silvia Monestiroli, Simona Ronzoni, Vania Gelmetti, Francesco Marchesi, Andrea Viale, Lucia Altucci, Clara Nervi, Saverio Minucci and Pier Giuseppe Pelicci Nature Medicine11, 71–76
(January 2005); doi:10.1038/nm1160
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letter Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
Angela Nebbioso, Nicole Clarke, Emilie Voltz, Emmanuelle Germain, Concetta Ambrosino, Paola Bontempo, Rosana Alvarez, Ettore M Schiavone, Felicetto Ferrara, Francesco Bresciani, Alessandro Weisz, Angel R de Lera, Hinrich Gronemeyer and Lucia Altucci Nature Medicine11, 77–84
(January 2005); doi:10.1038/nm1161
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review article Galectins as modulators of tumour progression
Fu-Tong Liu and Gabriel A. Rabinovich Nature Reviews Cancer5, 29–41
(January 2005); doi:10.1038/nrc1527
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review article p53: traffic cop at the crossroads of DNA repair and recombination
Sagar Sengupta and Curtis C. Harris Nature Reviews Molecular Cell Biology6, 44–55
(January 2005); doi:10.1038/nrm1546
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review article WNT signalling and haematopoiesis: a WNT-WNT situation
Frank J.T. Staal and Hans C. Clevers Nature Reviews Immunology5, 21–30
(January 2005); doi:10.1038/nri1529
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review article Osteoblasts in prostate cancer metastasis to bone
Christopher J. Logothetis and Sue-Hwa Lin Nature Reviews Cancer5, 21–28
(January 2005); doi:10.1038/nrc1528
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review article Dysregulation of the TSC-mTOR pathway in human disease
Ken Inoki, Michael N Corradetti and Kun-Liang Guan Nature Genetics37, 19–24
(January 2005); doi:10.1038/ng1494
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ej
í, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas and Jiri Bartek