Research library: Cancer

2007: December | November | October | September | August | July | June | May | April | March | February | January

Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2008

December

letter
Isolation of rare circulating tumour cells in cancer patients by microchip technology
Sunitha Nagrath et al.
Nature 450, 1235–1239
(20 December 2007); doi:10.1038/nature06385
| Summary | Full Text (HTML / PDF) |

letter
MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling
Rehan Ahmad et al.
Nature Cell Biology 9, 1419–1427
(December 2007); doi:10.1038/ncb1661
| Summary | Full Text (HTML / PDF) |

article
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
Matthias T Stephan et al.
Nature Medicine 13, 1440–1449
(December 2007); doi:10.1038/nm1676
| Summary | Full Text (HTML / PDF) |

news and views
Building the bionic T cell
Drew M Pardoll
Nature Medicine 13, 1411–1413
(December 2007); doi:10.1038/nm1207-1411
| Summary | Full Text (HTML / PDF) |

review
CHK2 kinase: cancer susceptibility and cancer therapy — two sides of the same coin?
Laurent Antoni, Nayanta Sodha, Ian Collins & Michelle D. Garrett
Nature Reviews Cancer 7, 925–936
(December 2007); doi:10.1038/nrc2251
| Summary | Full Text (HTML / PDF) |

news and views
A monkey wrench in the kinase machine
Daniel J Leahy
Nature Structural & Molecular Biology 14, 1120–1121
(December 2007); doi:10.1038/nsmb1207-1120
| Full Text (HTML / PDF) |

letter
A viral microRNA functions as an orthologue of cellular miR-155
Eva Gottwein et al.
Nature 450, 1096–1099
(13 December 2007); doi:10.1038/nature05992
| Summary | Full Text (HTML / PDF) |

review
Oncogenes and tumour suppressors take on centrosomes
Kenji Fukasawa
Nature Reviews Cancer 7, 911–924
(December 2007); doi:10.1038/nrc2249
| Summary | Full Text (HTML / PDF) |

article
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
Farbod Shojaei et al.
Nature 450, 825–831
(6 December 2007); doi:10.1038/nature06348
| Summary | Full Text (HTML / PDF) |

letter
Adaptive immunity maintains occult cancer in an equilibrium state
Catherine M. Koebel et al.
Nature 450, 903–907
(6 December 2007); doi:10.1038/nature06309
| Summary | Full Text (HTML / PDF) |

news and views
Cancer: Immune pact with the enemy
Cornelis J. M. Melief
Nature 450, 803–804
(6 December 2007); doi:10.1038/nature06363
| Full Text (HTML / PDF) |

perspective
Role of autophagy in cancer
Robin Mathew, Vassiliki Karantza-Wadsworth & Eileen White
Nature Reviews Cancer 7, 961–967
(December 2007); doi:10.1038/nrc2254
| Summary | Full Text (HTML / PDF) |

letter
Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor alpha
Konstantin Khetchoumian et al.
Nature Genetics 39, 1500–1506
(December 2007); doi:10.1038/ng.2007.15
| Summary | Full Text (HTML / PDF) |

November

news and views
APC and colon cancer: two hits for one
Craig J Ceol, David Pellman & Leonard I Zon
Nature Medicine 13, 1286–1287
(November 2007); doi:10.1038/nm1107-1286
| Summary | Full Text (HTML / PDF) |

review
MLL translocations, histone modifications and leukaemia stem-cell development
Andrei V. Krivtsov & Scott A. Armstrong
Nature Reviews Cancer 7, 823–833
(November 2007); doi:10.1038/nrc2253
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article
Network modeling links breast cancer susceptibility and centrosome dysfunction
Miguel Angel Pujana et al.
Nature Genetics 39, 1338–1349
(November 2007); doi:10.1038/ng.2007.2
| Summary | Full Text (HTML / PDF) |

letter
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
Massimo M Santoro, Temesgen Samuel, Tracy Mitchell, John C Reed & Didier Y R Stainier
Nature Genetics 39, 1397–1402
(November 2007); doi:10.1038/ng.2007.8
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news and views
Building in resistance to endothelial cell death
Massimiliano Mazzone, Carmen Ruiz de Almodovar & Peter Carmeliet
Nature Genetics 39, 1308–1309
(November 2007); doi:10.1038/ng1107-1308
| Full Text (HTML / PDF) |

article
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1
Heiko Johnen et al.
Nature Medicine 13, 1333–1340
(November 2007); doi:10.1038/nm1677
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letter
EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells
Carme Cortina et al.
Nature Genetics 39, 1376–1383
(November 2007); doi:10.1038/ng.2007.11
| Summary | Full Text (HTML / PDF) |

letter
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
Fumihiko Ishikawa et al.
Nature Biotechnology 25, 1315–1321
(November 2007); doi:10.1038/nbt1350
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review
The emerging roles of forkhead box (Fox) proteins in cancer
Stephen S. Myatt & Eric W. -F. Lam
Nature Reviews Cancer 7, 847–859
(November 2007); doi:10.1038/nrc2223
| Summary | Full Text (HTML / PDF) |

review
Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance
Anita Q. Gomes, Daniel V. Correia & Bruno Silva-Santos
EMBO Reports 8, 1024–1030
(November 2007); doi:10.1038/sj.embor.7401090
| Summary | Full Text (HTML / PDF) |

October

article
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Laura Soucek, Elizabeth R Lawlor, Darya Soto, Ksenya Shchors, Lamorna Brown Swigart & Gerard I Evan
Nature Medicine 13, 1211–1218
(October 2007); doi:10.1038/nm1649
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news and views
Where lies the blame for resistance-tumor or host?
Charles L Sawyers
Nature Medicine 13, 1144–1145
(October 2007); doi:10.1038/nm1007-1144
| Full Text (HTML / PDF) |

review
Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics
Pedro Jares, Dolors Colomer & Elias Campo
Nature Reviews Cancer 7, 750–762
(October 2007); doi:10.1038/nrc2230
| Summary | Full Text (HTML / PDF) |

review
Flying under the radar: the new wave of BCR-ABL inhibitors
Alfonso Quintás-Cardama, Hagop Kantarjian & Jorge Cortes
Nature Reviews Drug Discovery 6, 834–848
(October 2007); doi:10.1038/nrd2324
| Summary | Full Text (HTML / PDF) |

review
Illuminating the metastatic process
Erik Sahai
Nature Reviews Cancer 7, 737–749
(October 2007); doi:10.1038/nrc2229
| Summary | Full Text (HTML / PDF) |

article
Engineering tumors with 3D scaffolds
Claudia Fischbach et al.
Nature Methods 4, 855–860
(October 2007); doi:10.1038/nmeth1085
| Summary | Full Text (HTML / PDF) |

article
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Li Ma, Julie Teruya-Feldstein & Robert A. Weinberg
Nature 449, 682–688
(11 October 2007); doi:10.1038/nature06174
| Summary | Full Text (HTML / PDF) |

news and views
Cancer: Micromanagement of metastasis
Patricia S. Steeg
Nature 449, 671–673
(11 October 2007); doi:10.1038/449671a
| Full Text (HTML / PDF) |

review
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez & Ruth Lupu
Nature Reviews Cancer 7, 763–777
(October 2007); doi:10.1038/nrc2222
| Summary | Full Text (HTML / PDF) |

article
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Antoine E. Karnoub, Ajeeta B. Dash, Annie P. Vo, Andrew Sullivan, Mary W. Brooks, George W. Bell, Andrea L. Richardson, Kornelia Polyak, Ross Tubo & Robert A. Weinberg
Nature 449, 557–563
(4 October 2007); doi:10.1038/nature06188
| Summary | Full Text (HTML / PDF) |

news and views
Micromanaging metastasis
Alison Schuldt
Nature Cell Biology 9, 1121
(October 2007); doi:10.1038/ncb1007-1121
| Full Text (HTML / PDF) |

review
Lung cancer in never smokers — a different disease
Sophie Sun, Joan H. Schiller & Adi F. Gazdar
Nature Reviews Cancer 7, 778–790
(October 2007); doi:10.1038/nrc2190
| Summary | Full Text (HTML / PDF) |

review
RAR and RXR modulation in cancer and metabolic disease
Lucia Altucci, Mark D. Leibowitz, Kathleen M. Ogilvie, Angel R. de Lera & Hinrich Gronemeyer
Nature Reviews Drug Discovery 6, 793–810
(October 2007); doi:10.1038/nrd2397
| Summary | Full Text (HTML / PDF) |

review
Design of selective nuclear receptor modulators: RAR and RXR as a case study
Angel R. de Lera, William Bourguet, Lucia Altucci & Hinrich Gronemeyer
Nature Reviews Drug Discovery 6, 811–820
(October 2007); doi:10.1038/nrd2398
| Summary | Full Text (HTML / PDF) |

September

review
Cell polarity in development and cancer
Andreas Wodarz & Inke Näthke
Nature Cell Biology 9, 1016–1024
(September 2007); doi:10.1038/ncb433
| Summary | Full Text (HTML / PDF) |

perspective
Cancer and ageing: convergent and divergent mechanisms
Manuel Serrano & Maria A. Blasco
Nature Reviews Molecular Cell Biology 8, 715–722
(September 2007); doi:10.1038/nrm2242
| Summary | Full Text (HTML / PDF) |

article
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Klaus W Wagner, Elizabeth A Punnoose, Thomas Januario, David A Lawrence, Robert M Pitti, Kate Lancaster, Dori Lee, Melissa von Goetz, Sharon Fong Yee, Klara Totpal, Ling Huw, Viswanatham Katta, Guy Cavet, Sarah G Hymowitz, Lukas Amler & Avi Ashkenazi
Nature Medicine 13, 1070–1077
(September 2007); doi:10.1038/nm1627
| Summary | Full Text (HTML / PDF) |

review
Modelling breast cancer: one size does not fit all
Tracy Vargo-Gogola & Jeffrey M. Rosen
Nature Reviews Cancer 7, 659–672
(September 2007); doi:10.1038/nrc2193
| Summary | Full Text (HTML / PDF) |

perspective
Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state
Kelly A. Green & Jason S. Carroll
Nature Reviews Cancer 7, 713–722
(September 2007); doi:10.1038/nrc2211
| Summary | Full Text (HTML / PDF) |

article
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi & Minoru Yoshida
Nature Chemical Biology 3, 576–583
(September 2007); doi:10.1038/nchembio.2007.18
| Summary | Full Text (HTML / PDF) |

letter
Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake, Koji Sagane, Takashi Owa, Yuko Mimori-Kiyosue, Hajime Shimizu, Mai Uesugi, Yasushi Ishihama, Masao Iwata & Yoshiharu Mizui
Nature Chemical Biology 3, 570–575
(September 2007); doi:10.1038/nchembio.2007.16
| Summary | Full Text (HTML / PDF) |

news and views
Targeting the spliceosome
Brian Rymond
Nature Chemical Biology 3, 533–535
(September 2007); doi:10.1038/nchembio0907-533
| Summary | Full Text (HTML / PDF) |

article
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
Liyong Zhang, Michael S Anglesio, Maureen O'Sullivan, Fan Zhang, Ge Yang, Renu Sarao, Mai P Nghiem, Shane Cronin, Hiromitsu Hara, Nataliya Melnyk, Liheng Li, Teiji Wada, Peter P Liu, Jason Farrar, Robert J Arceci, Poul H Sorensen & Josef M Penninger
Nature Medicine 13, 1060–1069
(September 2007); doi:10.1038/nm1621
| Summary | Full Text (HTML / PDF) |

review
Maximizing mouse cancer models
Kristopher K. Frese & David A. Tuveson
Nature Reviews Cancer 7, 654–658
(September 2007); doi:10.1038/nrc2192
| Summary | Full Text (HTML / PDF) |

review
Molecular basis for sunitinib efficacy and future clinical development
Sandrine Faivre, George Demetri, William Sargent & Eric Raymond
Nature Reviews Drug Discovery 6, 734–745
(September 2007); doi:10.1038/nrd2380
| Summary | Full Text (HTML / PDF) |

article
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
Natalia Mitin, Laurie Betts, Marielle E Yohe, Channing J Der, John Sondek & Kent L Rossman
Nature Structural & Molecular Biology 14, 814–823
(September 2007); doi:10.1038/nsmb1290
| Summary | Full Text (HTML / PDF) |

article
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Lionel Apetoh, François Ghiringhelli, Antoine Tesniere, Michel Obeid, Carla Ortiz, Alfredo Criollo, Grégoire Mignot, M Chiara Maiuri, Evelyn Ullrich, Patrick Saulnier, Huan Yang, Sebastian Amigorena, Bernard Ryffel, Franck J Barrat, Paul Saftig, Francis Levi, Rosette Lidereau, Catherine Nogues, Jean-Paul Mira, Agnès Chompret, Virginie Joulin, Françoise Clavel-Chapelon, Jean Bourhis, Fabrice André, Suzette Delaloge, Thomas Tursz, Guido Kroemer & Laurence Zitvogel
Nature Medicine 13, 1050–1059
(2007); doi:10.1038/nm1622
| Summary | Full Text (HTML / PDF) |

review
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
Ross L. Levine, Animesh Pardanani, Ayalew Tefferi & D. Gary Gilliland
Nature Reviews Cancer 7, 673–683
(September 2007); doi:10.1038/nrc2210
| Summary | Full Text (HTML / PDF) |

letter
p53 is regulated by the lysine demethylase LSD1
Jing Huang, Roopsha Sengupta, Alexsandra B. Espejo, Min Gyu Lee, Jean A. Dorsey, Mario Richter, Susanne Opravil, Ramin Shiekhattar, Mark T. Bedford, Thomas Jenuwein & Shelley L. Berger
Nature 449, 105–108
(6 September 2007); doi:10.1038/nature06092
| Summary | Full Text (HTML / PDF) |

review
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Kristin K. Deeb, Donald L. Trump & Candace S. Johnson
Nature Reviews Cancer 7, 684–700
(September 2007); doi:10.1038/nrc2196
| Summary | Full Text (HTML / PDF) |

perspective
Building better magic bullets — improving unconjugated monoclonal antibody therapy for cancer
Louis M. Weiner
Nature Reviews Cancer 7, 701–706
(September 2007); doi:10.1038/nrc2209
| Summary | Full Text (HTML / PDF) |

brief communication
Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection
Brock A Peters, Zhengyan Kan, Dragan Sebisanovic, Kanan Pujara, Zhiyong Wang, Peter Hong, Bernard Chow, Jeremy Stinson, Victoria E H Carlton, Thinh Q Pham, Howard Stern, Paul Waring, Kenneth J Hillan, David A Eberhard, Frederic de Sauvage, Jianbiao Zheng, Malek Faham & Somasekar Seshagiri
Nature Methods 4, 713–715
(September 2007); doi:10.1038/nmeth1081
| Summary | Full Text (HTML / PDF) |

August

letter
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Chiara Gorrini, Massimo Squatrito, Chiara Luise, Nelofer Syed, Daniele Perna, Landon Wark, Francesca Martinato, Domenico Sardella, Alessandro Verrecchia, Samantha Bennett, Stefano Confalonieri, Matteo Cesaroni, Francesco Marchesi, Milena Gasco, Eugenio Scanziani, Maria Capra, Sabine Mai, Paolo Nuciforo, Tim Crook, John Lough & Bruno Amati
Nature 448, 1063–1067
(30 August 2007); doi:10.1038/nature06055
| Summary | Full Text (HTML / PDF) |

review
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
Teru Hideshima, Constantine Mitsiades, Giovanni Tonon, Paul G. Richardson & Kenneth C. Anderson
Nature Reviews Cancer 7, 585–598
(August 2007); doi:10.1038/nrc2189
| Summary | Full Text (HTML / PDF) |

article
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b⁺Gr1⁺ myeloid cells
Farbod Shojaei, Xiumin Wu, Ajay K Malik, Cuiling Zhong, Megan E Baldwin, Stefanie Schanz, Germaine Fuh, Hans-Peter Gerber & Napoleone Ferrara
Nature Biotechnology 25, 911–920
(August 2007); doi:10.1038/nbt1323
| Summary | Full Text (HTML / PDF) |

article
Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Xiao-Qing Qiu, He Wang, Bei Cai, Lan-Lan Wang & Shi-Tao Yue
Nature Biotechnology 25, 921–929
(August 2007); doi:10.1038/nbt1320
| Summary | Full Text (HTML / PDF) |

news and views
Antibodies cut down to size
Robert Charles Ladner
Nature Biotechnology 25, 875–877
(August 2007); doi:10.1038/nbt0807-875
| Summary | Full Text (HTML / PDF) |

letter
p15^Ink4b is a critical tumour suppressor in the absence of p16^Ink4a
Paul Krimpenfort, Annemieke IJpenberg, Ji-Ying Song, Martin van der Valk, Martijn Nawijn, John Zevenhoven & Anton Berns
Nature 448, 943–946
(23 August 2007); doi:10.1038/nature06084
| Summary | Full Text (HTML / PDF) |

article
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
Katarina Wolf, Yi I. Wu, Yueying Liu, Jörg Geiger, Eric Tam, Christopher Overall, M. Sharon Stack & Peter Friedl
Nature Cell Biology 9, 893–904
(August 2007); doi:10.1038/ncb1616
| Summary | Full Text (HTML / PDF) |

review
Angiogenesis in brain tumours
Rakesh K. Jain, Emmanuelle di Tomaso, Dan G. Duda, Jay S. Loeffler, A. Gregory Sorensen & Tracy T. Batchelor
Nature Reviews Neuroscience 8, 610–622
(August 2007); doi:10.1038/nrn2175
| Summary | Full Text (HTML / PDF) |

article
CCDC98 is a BRCA1–BRCT domain-binding protein involved in the DNA damage response
Hongtae Kim, Jun Huang & Junjie Chen
Nature Structural & Molecular Biology 14, 710–715
(August 2007); doi:10.1038/nsmb1277
| Summary | Full Text (HTML / PDF) |

article
CCDC98 targets BRCA1 to DNA damage sites
Zixing Liu, Jiaxue Wu & Xiaochun Yu
Nature Structural & Molecular Biology 14, 716–720
(August 2007); doi:10.1038/nsmb1279
| Summary | Full Text (HTML / PDF) |

article
Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
Nicole-Claudia Meisner, Martin Hintersteiner, Kurt Mueller, Roman Bauer, Jan-Marcus Seifert, Hans-Ulrich Naegeli, Johannes Ottl, Lukas Oberer, Christian Guenat, Serge Moss, Nathalie Harrer, Maximilian Woisetschlaeger, Christof Buehler, Volker Uhl & Manfred Auer
Nature Chemical Biology 3, 508–515
(August 2007); doi:10.1038/nchembio.2007.14
| Summary | Full Text (HTML / PDF) |

letter
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji et al.
Nature 448, 807–810
(16 August 2007); doi:10.1038/nature06030
| Summary | Full Text (HTML / PDF) |

review
The common biology of cancer and ageing
Toren Finkel, Manuel Serrano & Maria A. Blasco
Nature 448, 767–774
(16 August 2007); doi:10.1038/nature05985
| Summary | Full Text (HTML / PDF) |

review
The resurgence of platinum-based cancer chemotherapy
Lloyd Kelland
Nature Reviews Cancer 7, 573–584
(August 2007); doi:10.1038/nrc2167
| Summary | Full Text (HTML / PDF) |

article
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Julie Litz, Cristina C Clement, Yanlong Kang, Yuhong She, Nian Wu, Sara Felts, Peter Wipf, Joan Massague, Xuejun Jiang, Jeffrey L Brodsky, Geoffrey W Krystal & Gabriela Chiosis
Nature Chemical Biology 3, 498–507
(August 2007); doi:10.1038/nchembio.2007.10
| Summary | Full Text (HTML / PDF) |

news and views
Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer
Paul Workman & Marissa V Powers
Nature Chemical Biology 3, 455–457
(August 2007); doi:10.1038/nchembio0807-455
| Full Text (HTML / PDF) |

perspective
Treating prostate cancer: a rationale for targeting local oestrogens
Stuart J. Ellem & Gail P. Risbridger
Nature Reviews Cancer 7, 621–627
(August 2007); doi:10.1038/nrc2174
| Summary | Full Text (HTML / PDF) |

review
Mining gene expression profiles: expression signatures as cancer phenotypes
Joseph R. Nevins & Anil Potti
Nature Reviews Genetics 8, 601–609
(August 2007); doi:10.1038/nrg2137
| Summary | Full Text (HTML / PDF) |

review
Molecular mechanisms of alcohol-mediated carcinogenesis
Helmut K. Seitz & Felix Stickel
Nature Reviews Cancer 7, 599–612
(August 2007); doi:10.1038/nrc2191
| Summary | Full Text (HTML / PDF) |

July

article
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas
Nature 448, 439–444
(26 July 2007); doi:10.1038/nature05933
| Summary | Full Text (HTML / PDF) |

article
The ubiquitin-specific protease USP28 is required for MYC stability
Nikita Popov, Michael Wanzel, Mandy Madiredjo, Dong Zhang, Roderick Beijersbergen, Rene Bernards, Roland Moll, Stephen J. Elledge & Martin Eilers
Nature Cell Biology 9, 765–774
(July 2007); doi:10.1038/ncb1601
| Summary | Full Text (HTML / PDF) |

news and views
MYC degradation: deubiquitinating enzymes enter the dance
Bruno Amati & Victor J. Sanchez-Arévalo Lobo
Nature Cell Biology 9, 729–731
(July 2007); doi:10.1038/ncb0707-729
| Summary | Full Text (HTML / PDF) |

review
Gene methylation and early detection of genitourinary cancer: the road ahead
Paul Cairns
Nature Reviews Cancer 7, 531–543
(July 2007); doi:10.1038/nrc2170
| Summary | Full Text (HTML / PDF) |

perspective
Targeting the protein kinase C family: are we there yet?
Helen J. Mackay & Christopher J. Twelves
Nature Reviews Cancer 7, 554–562
(July 2007); doi:10.1038/nrc2168
| Summary | Full Text (HTML / PDF) |

letter
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
David J Hunter, Peter Kraft, Kevin B Jacobs, David G Cox, Meredith Yeager, Susan E Hankinson, Sholom Wacholder, Zhaoming Wang, Robert Welch, Amy Hutchinson, Junwen Wang, Kai Yu, Nilanjan Chatterjee, Nick Orr, Walter C Willett, Graham A Colditz, Regina G Ziegler, Christine D Berg, Saundra S Buys, Catherine A McCarty, Heather Spencer Feigelson, Eugenia E Calle, Michael J Thun, Richard B Hayes, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Jr, Robert N Hoover, Gilles Thomas & Stephen J Chanock
Nature Genetics 39, 870–874
(July 2007); doi:10.1038/ng2075
| Summary | Full Text (HTML / PDF) |

news and views
ENCODE and our very busy genome
Steven Henikoff
Nature Genetics 39, 817–818
(July 2007); doi:10.1038/ng0707-817
| Summary | Full Text (HTML / PDF) |

letter
NUP98–NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
Gang G. Wang, Ling Cai, Martina P. Pasillas & Mark P. Kamps
Nature Cell Biology 9, 804–812
(July 2007); doi:10.1038/ncb1608
| Summary | Full Text (HTML / PDF) |

article
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
Li Zheng, Huifang Dai, Mian Zhou, Mei Li, Purnima Singh, Junzhuan Qiu, Walter Tsark, Qin Huang, Kemp Kernstine, Xuemei Zhang, Dongxin Lin & Binghui Shen
Nature Medicine 13, 812–819
(July 2007); doi:10.1038/nm1599
| Summary | Full Text (HTML / PDF) |

review
Calcium and cancer: targeting Ca²⁺ transport
Gregory R. Monteith, Damara McAndrew, Helen M. Faddy & Sarah J. Roberts-Thomson
Nature Reviews Cancer 7, 519–530
(July 2007); doi:10.1038/nrc2171
| Summary | Full Text (HTML / PDF) |

perspective
Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?
Christos Sotiriou & Martine J. Piccart
Nature Reviews Cancer 7, 545–553
(July 2007); doi:10.1038/nrc2173
| Summary | Full Text (HTML / PDF) |

article
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins
Patrick Ryan Potts & Hongtao Yu
Nature Structural & Molecular Biology 14, 581–590
(July 2007); doi:10.1038/nsmb1259
| Summary | Full Text (HTML / PDF) |

news and views
A SUMO ligase for ALT
Roger R Reddel
Nature Structural & Molecular Biology 14, 570–571
(July 2007); doi:10.1038/nsmb0707-570
| Summary | Full Text (HTML / PDF) |

review
Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development
Gary J. Kelloff & Caroline C. Sigman
Nature Reviews Cancer 7, 508–518
(July 2007); doi:10.1038/nrc2154
| Summary | Full Text (HTML / PDF) |

review
CDC25 phosphatases in cancer cells: key players? Good targets?
Rose Boutros, Valérie Lobjois & Bernard Ducommun
Nature Reviews Cancer 7, 495–507
(July 2007); doi:10.1038/nrc2169
| Summary | Full Text (HTML / PDF) |

review
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
Panagiotis A. Konstantinopoulos, Michalis V. Karamouzis & Athanasios G. Papavassiliou
Nature Reviews Drug Discovery 6, 541–555
(July 2007); doi:10.1038/nrd2221
| Summary | Full Text (HTML / PDF) |

June

article
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton, et al.
Nature 447, 1087–1093
(28 June 2007); doi:10.1038/nature05887
| Summary | Full Text (HTML / PDF) |

letter
A microRNA component of the p53 tumour suppressor network
Lin He, Xingyue He, Lee P. Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon, Aimee L. Jackson, Peter S. Linsley, Caifu Chen, Scott W. Lowe, Michele A. Cleary & Gregory J. Hannon
Nature 447, 1130–1134
(28 June 2007); doi:10.1038/nature05939
| Summary | Full Text (HTML / PDF) |

letter
Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia
Shannon E Mullican, Shuo Zhang, Marina Konopleva, Vivian Ruvolo, Michael Andreeff, Jeffrey Milbrandt & Orla M Conneely
Nature Medicine 13, 730–735
(June 2007); doi:10.1038/nm1579
| Summary | Full Text (HTML / PDF) |

letter
Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
Hind Medyouf, Hélène Alcalde, Caroline Berthier, Marie Claude Guillemin, Nuno R dos Santos, Anne Janin, Didier Decaudin, Hugues de Thé & Jacques Ghysdael
Nature Medicine 13, 736–741
(June 2007); doi:10.1038/nm1588
| Summary | Full Text (HTML / PDF) |

news and views
Linking calcineurin activity to leukemogenesis
Martin R Müller & Anjana Rao
Nature Medicine 13, 669–671
(June 2007); doi:10.1038/nm0607-669
| Summary | Full Text (HTML / PDF) |

review
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Héctor Peinado, David Olmeda & Amparo Cano
Nature Reviews Cancer 7, 415–428
(June 2007); doi:10.1038/nrc2131
| Summary | Full Text (HTML / PDF) |

review
Chronic myeloid leukaemia as a model of disease evolution in human cancer
Junia V. Melo & David J. Barnes
Nature Reviews Cancer 7, 441–453
(June 2007); doi:10.1038/nrc2147
| Summary | Full Text (HTML / PDF) |

article
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
Vassiliki Theodorou, Melanie A Kimm, Mandy Boer, Lodewyk Wessels, Wendy Theelen, Jos Jonkers & John Hilkens
Nature Genetics 39, 759–769
(June 2007); doi:10.1038/ng2034
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article
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser, Bhudipa Choudhury, Peter J. Campbell, Bin Feng, Kwok-Kin Wong, Alexei Protopopov, Jennifer O'Neil, Alejandro Gutierrez, Elena Ivanova, Ilana Perna, Eric Lin, Vidya Mani, Shan Jiang, Kate McNamara, Sara Zaghlul, Sarah Edkins, Claire Stevens, Cameron Brennan, Eric S. Martin, Ruprecht Wiedemeyer, Omar Kabbarah, Cristina Nogueira, Gavin Histen, Jon Aster, Marc Mansour, Veronique Duke, Letizia Foroni, Adele K. Fielding, Anthony H. Goldstone, Jacob M. Rowe, Yaoqi A. Wang, A. Thomas Look, Michael R. Stratton, Lynda Chin, P. Andrew Futreal & Ronald A. DePinho
Nature 447, 966–971
(21 June 2007); doi:10.1038/nature05886
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review
The cofilin pathway in breast cancer invasion and metastasis
Weigang Wang, Robert Eddy & John Condeelis
Nature Reviews Cancer 7, 429–440
(June 2007); doi:10.1038/nrc2148
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review
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
Cayetano Gonzalez
Nature Reviews Genetics 8, 462–472
(June 2007); doi:10.1038/nrg2103
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article
Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
Yoshihiro Kobashigawa, Mieko Sakai, Masato Naito, Masashi Yokochi, Hiroyuki Kumeta, Yoshinori Makino, Kenji Ogura, Shinya Tanaka & Fuyuhiko Inagaki
Nature Structural & Molecular Biology 14, 503–510
(June 2007); doi:10.1038/nsmb1241
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news and views
Moving parts: how the adaptor protein CRK is regulated, and regulates
David Cowburn
Nature Structural & Molecular Biology 14, 465–466
(June 2007); doi:10.1038/nsmb0607-465
| Summary | Full Text (HTML / PDF) |

technical report
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
Eva Hernando, Elizabeth Charytonowicz, Maria E Dudas, Silvia Menendez, Igor Matushansky, Joslyn Mills, Nicholas D Socci, Nille Behrendt, Li Ma, Robert G Maki, Pier Paolo Pandolfi & Carlos Cordon-Cardo
Nature Medicine 13, 748–753
(June 2007); doi:10.1038/nm1560
| Summary | Full Text (HTML / PDF) |

progress
Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation
Leonardo Salmena & Pier Paolo Pandolfi
Nature Reviews Cancer 7, 409–413
(June 2007); doi:10.1038/nrc2145
| Summary | Full Text (HTML / PDF) |

review
Morphogens, morphostats, microarchitecture and malignancy
John D. Potter
Nature Reviews Cancer 7, 464–474
(June 2007); doi:10.1038/nrc2146
| Summary | Full Text (HTML / PDF) |

perspective
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
Henk M. W. Verheul & Herbert M. Pinedo
Nature Reviews Cancer 7, 475–485
(June 2007); doi:10.1038/nrc2152
| Summary | Full Text (HTML / PDF) |

article
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
Lijian Hui, Latifa Bakiri, Andreas Mairhorfer, Norbert Schweifer, Christian Haslinger, Lukas Kenner, Vukoslav Komnenovic, Harald Scheuch, Hartmut Beug & Erwin F Wagner
Nature Genetics 39, 741–749
(June 2007); doi:10.1038/ng2033
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article
p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
Juan José Ventura, Stephan Tenbaum, Eusebio Perdiguero, Marion Huth, Carmen Guerra, Mariano Barbacid, Manolis Pasparakis & Angel R Nebreda
Nature Genetics 39, 750–758
(June 2007); doi:10.1038/ng2037
| Summary | Full Text (HTML / PDF) |

review
Nuclear microenvironments in biological control and cancer
Sayyed K. Zaidi, Daniel W. Young, Amjad Javed, Jitesh Pratap, Martin Montecino, Andre van Wijnen, Jane B. Lian, Janet L. Stein & Gary S. Stein
Nature Reviews Cancer 7, 454–463
(June 2007); doi:10.1038/nrc2149
| Summary | Full Text (HTML / PDF) |

May

letter
Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands
Brett K. Kaiser, Daesong Yim, I-Ting Chow, Segundo Gonzalez, Zhenpeng Dai, Henning H. Mann, Roland K. Strong, Veronika Groh & Thomas Spies
Nature 447, 482–486
(24 May 2007); doi:10.1038/nature05768
| Summary | Full Text (HTML / PDF) |

review
Laminin 332 in squamous-cell carcinoma
M. Peter Marinkovich
Nature Reviews Cancer 7, 370–380
(May 2007); doi:10.1038/nrc2089
| Summary | Full Text (HTML / PDF) |

progress
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
Gavin Thurston, Irene Noguera-Troise & George D. Yancopoulos
Nature Reviews Cancer 7, 327–331
(May 2007); doi:10.1038/nrc2130
| Summary | Full Text (HTML / PDF) |

brief communication
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Idoya Lahortiga, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink & Jan Cools
Nature Genetics 39, 593–595
(May 2007); doi:10.1038/ng2025
| Summary | Full Text (HTML / PDF) |

review
Genetic determinants of cancer metastasis
Don X. Nguyen & Joan Massagué
Nature Reviews Genetics 8, 341–352
(May 2007); doi:10.1038/nrg2101
| Summary | Full Text (HTML / PDF) |

review
Pax5: the guardian of B cell identity and function
César Cobaleda, Alexandra Schebesta, Alessio Delogu & Meinrad Busslinger
Nature Immunology 8, 463–470
(May 2007); doi:10.1038/ni1454
| Summary | Full Text (HTML / PDF) |

review
Second generation inhibitors of BCR–ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
Ellen Weisberg, Paul W. Manley, Sandra W. Cowan-Jacob, Andreas Hochhaus & James D. Griffin
Nature Reviews Cancer 7, 345–356
(May 2007); doi:10.1038/nrc2126
| Summary | Full Text (HTML / PDF) |

perspective
Insights from transgenic mouse models of ERBB2-induced breast cancer
Josie Ursini-Siegel, Babette Schade, Robert D. Cardiff & William J. Muller
Nature Reviews Cancer 7, 389–397
(May 2007); doi:10.1038/nrc2127
| Summary | Full Text (HTML / PDF) |

letter
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Frederik Holst, Phillip R Stahl, Christian Ruiz, Olaf Hellwinkel, Zeenath Jehan, Marc Wendland, Annette Lebeau, Luigi Terracciano, Khawla Al-Kuraya, Fritz Jänicke, Guido Sauter & Ronald Simon
Nature Genetics 39, 655–660
(May 2007); doi:10.1038/ng2006
| Summary | Full Text (HTML / PDF) |

letter
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Madhu S Kumar, Jun Lu, Kim L Mercer, Todd R Golub & Tyler Jacks
Nature Genetics 39, 673–677
(May 2007); doi:10.1038/ng2003
| Summary | Full Text (HTML / PDF) |

news and views
MicroRNAs as tumor suppressors
Scott M Hammond
Nature Genetics 39, 582–583
(May 2007); doi:10.1038/ng0507-582
| Summary | Full Text (HTML / PDF) |

perspective
Development trends for monoclonal antibody cancer therapeutics
Janice M. Reichert & Viia E. Valge-Archer
Nature Reviews Drug Discovery 6, 349–356
(May 2007); doi:10.1038/nrd2241
| Summary | Full Text (HTML / PDF) |

scientific report
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
Wilfredo Cosme-Blanco, Mei-Feng Shen, Alexander J F Lazar, Sen Pathak, Guillermina Lozano, Asha S Multani & Sandy Chang
EMBO Reports 8, 497–503
(May 2007); doi:10.1038/sj.embor.7400937
| Summary | Full Text (HTML / PDF) |

news and views
PIN1, the cell cycle and cancer
Elizabeth S. Yeh & Anthony R. Means
Nature Reviews Cancer 7, 381–388
(May 2007); doi:10.1038/nrc2107
| Summary | Full Text (HTML / PDF) |

letter
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Julius Gudmundsson, Patrick Sulem, Andrei Manolescu, Laufey T Amundadottir, Daniel Gudbjartsson, Agnar Helgason, Thorunn Rafnar, Jon T Bergthorsson, Bjarni A Agnarsson, Adam Baker, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Margret Jakobsdottir, Jianfeng Xu, Thorarinn Blondal, Jelena Kostic, Jielin Sun, Shyamali Ghosh, Simon N Stacey, Magali Mouy, Jona Saemundsdottir, Valgerdur M Backman, Kristleifur Kristjansson, Alejandro Tres, Alan W Partin, Marjo T Albers-Akkers, Javier Godino-Ivan Marcos, Patrick C Walsh, Dorine W Swinkels, Sebastian Navarrete, Sarah D Isaacs, Katja K Aben, Theresa Graif, John Cashy, Manuel Ruiz-Echarri, Kathleen E Wiley, Brian K Suarez, J Alfred Witjes, Mike Frigge, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jose I Mayordomo, Lambertus A Kiemeney, William B Isaacs, William J Catalona, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong & Kari Stefansson
Nature Genetics 39, 631–637
(May 2007); doi:10.1038/ng1999
| Summary | Full Text (HTML / PDF) |

letter
Multiple regions within 8q24 independently affect risk for prostate cancer
Christopher A Haiman, Nick Patterson, Matthew L Freedman, Simon R Myers, Malcolm C Pike, Alicja Waliszewska, Julie Neubauer, Arti Tandon, Christine Schirmer, Gavin J McDonald, Steven C Greenway, Daniel O Stram, Loic Le Marchand, Laurence N Kolonel, Melissa Frasco, David Wong, Loreall C Pooler, Kristin Ardlie, Ingrid Oakley-Girvan, Alice S Whittemore, Kathleen A Cooney, Esther M John, Sue A Ingles, David Altshuler, Brian E Henderson & David Reich
Nature Genetics 39, 638–644
(May 2007); doi:10.1038/ng2015
| Summary | Full Text (HTML / PDF) |

letter
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Meredith Yeager, Nick Orr, Richard B Hayes, Kevin B Jacobs, Peter Kraft, Sholom Wacholder, Mark J Minichiello, Paul Fearnhead, Kai Yu, Nilanjan Chatterjee, Zhaoming Wang, Robert Welch, Brian J Staats, Eugenia E Calle, Heather Spencer Feigelson, Michael J Thun, Carmen Rodriguez, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Edward Giovannucci, Walter C Willett, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, Edward P Gelmann, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Jr, Robert Hoover, David J Hunter, Stephen J Chanock & Gilles Thomas
Nature Genetics 39, 645–649
(May 2007); doi:10.1038/ng2022
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news and views
Multiple prostate cancer risk variants on 8q24
John S Witte
Nature Genetics 39, 577
(May 2007); doi:10.1038/ng0507-579
| Summary | Full Text (HTML / PDF) |

letter
Chemical genetics reveals a complex functional ground state of neural stem cells
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers and Peter B Dirks
Nature Chemical Biology 3, 268–273
(May 2007); doi:10.1038/nchembio873
| Summary | Full Text (HTML / PDF) |

news and views
Chemical probes of neural stem cell self-renewal
Mark Mercola
Nature Chemical Biology 3, 246–247
(May 2007); doi:10.1038/nchembio0507-246
| Summary | Full Text (HTML / PDF) |

article
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
Christopher J. Sarkisian, Blaine A. Keister, Douglas B. Stairs, Robert B. Boxer, Susan E. Moody & Lewis A. Chodosh
Nature Cell Biology 9, 493–505
(May 2007); doi:10.1038/ncb1567
| Summary | Full Text (HTML / PDF) |

review
Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
Thomas Force, Daniela S. Krause & Richard A. Van Etten
Nature Reviews Cancer 7, 332–344
(May 2007); doi:10.1038/nrc2106
| Summary | Full Text (HTML / PDF) |

April

letter
Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL₂
Xiaobo Wang, Karine Belguise, Nathalie Kersual, Kathrin H. Kirsch, Nora D. Mineva, Florence Galtier, Dany Chalbos & Gail E. Sonenshein
Nature Cell Biology 9, 470–478
(April 2007); doi:10.1038/ncb1559
| Summary | Full Text (HTML / PDF) |

news and views
NF-κB links oestrogen receptor signalling and EMT
Derek C. Radisky & Mina J. Bissell
Nature Cell Biology 9, 361–363
(April 2007); doi:10.1038/ncb0407-361
| Summary | Full Text (HTML / PDF) |

review
Inflammation in prostate carcinogenesis
Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe, Jianfeng Xu, Henrik Grönberg, Charles G. Drake, Yasutomo Nakai, William B. Isaacs & William G. Nelson
Nature Reviews Cancer 7, 256–269
(April 2007); doi:10.1038/nrc2090
| Summary | Full Text (HTML / PDF) |

review
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Masao Matsuoka & Kuan-Teh Jeang
Nature Reviews Cancer 7, 270–280
(April 2007); doi:10.1038/nrc2111
| Summary | Full Text (HTML / PDF) |

review
The impact of translocations and gene fusions on cancer causation
Felix Mitelman, Bertil Johansson & Fredrik Mertens
Nature Reviews Cancer 7, 233–245
(April 2007); doi:10.1038/nrc2091
| Summary | Full Text (HTML / PDF) |

review
Reprogramming metastatic tumour cells with embryonic microenvironments
Mary J. C. Hendrix, Elisabeth A. Seftor, Richard E. B. Seftor, Jennifer Kasemeier-Kulesa, Paul M. Kulesa & Lynne-Marie Postovit
Nature Reviews Cancer 7, 246–255
(April 2007); doi:10.1038/nrc2108
| Summary | Full Text (HTML / PDF) |

article
SMAD4-deficient intestinal tumors recruit CCR1⁺ myeloid cells that promote invasion
Takanori Kitamura, Kohei Kometani, Hiroki Hashida, Akihiro Matsunaga, Hiroyuki Miyoshi, Hisahiro Hosogi, Masahiro Aoki, Masanobu Oshima, Masakazu Hattori, Arimichi Takabayashi, Nagahiro Minato & Makoto M Taketo
Nature Genetics 39, 467–475
(April 2007); doi:10.1038/ng1997
| Summary | Full Text (HTML / PDF) |

article
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gaorav P. Gupta, Don X. Nguyen, Anne C. Chiang, Paula D. Bos, Juliet Y. Kim, Cristina Nadal, Roger R. Gomis, Katia Manova-Todorova & Joan Massagué
Nature 446, 765–770
(11 April 2007); doi:10.1038/nature05760
| Summary | Full Text (HTML / PDF) |

news and views
Cancer: Division of labour
Gerhard Christofori
Nature 446, 735–735
(11 April 2007); doi:10.1038/446735a
| Summary | Full Text (HTML / PDF) |

letter
Synthetic lethal screen identification of chemosensitizer loci in cancer cells
Angelique W. Whitehurst, Brian O. Bodemann, Jessica Cardenas, Deborah Ferguson, Luc Girard, Michael Peyton, John D. Minna, Carolyn Michnoff, Weihua Hao, Michael G. Roth, Xian-Jin Xie & Michael A. White
Nature 446, 815–819
(11 April 2007); doi:10.1038/nature05697
| Summary | Full Text (HTML / PDF) |

review
Protein kinase C and other diacylglycerol effectors in cancer
Erin M. Griner & Marcelo G. Kazanietz
Nature Reviews Cancer 7, 281–294
(April 2007); doi:10.1038/nrc2110
| Summary | Full Text (HTML / PDF) |

letter
Myc deletion rescues Apc deficiency in the small intestine
Owen J. Sansom, Valerie S. Meniel, Vanesa Muncan, Toby J. Phesse, Julie A. Wilkins, Karen R. Reed, J. Keith Vass, Dimitris Athineos, Hans Clevers & Alan R. Clarke
Nature 446, 676–679
(5 April 2007); doi:10.1038/nature05674
| Summary | Full Text (HTML / PDF) |

letter
Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
Jun-Li Luo, Wei Tan, Jill M. Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L. Gonias, David A. Cheresh & Michael Karin
Nature 446, 690–694
(5 April 2007); doi:10.1038/nature05656
| Summary | Full Text (HTML / PDF) |

review
Hyperactive Ras in developmental disorders and cancer
Suzanne Schubbert, Kevin Shannon & Gideon Bollag
Nature Reviews Cancer 7, 295–308
(April 2007); doi:10.1038/nrc2109
| Summary | Full Text (HTML / PDF) |

perspective
Shaping the future of biomarker research in breast cancer to ensure clinical relevance
M. Carolina Hinestrosa, Kay Dickersin, Pamela Klein, Musa Mayer, Karin Noss, Dennis Slamon, George Sledge & Frances M. Visco
Nature Reviews Cancer 7, 309–315
(April 2007); doi:10.1038/nrc2113
| Summary | Full Text (HTML / PDF) |

March

review
Epidermal growth factor receptor mutations in lung cancer
Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman & Daniel A. Haber
Nature Reviews Cancer 7, 169–181
(March 2007); doi:10.1038/nrc2088
| Summary | Full Text (HTML / PDF) |

review
The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network
Kieran Harvey & Nicolas Tapon
Nature Reviews Cancer 7, 182–191
(March 2007); doi:10.1038/nrc2070
| Summary | Full Text (HTML / PDF) |

article
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis
Sofi G Julien, Nadia Dubé, Michelle Read, Janice Penney, Marilene Paquet, Yongxin Han, Brian P Kennedy, William J Muller & Michel L Tremblay
Nature Genetics 39, 338–346
(March 2007); doi:10.1038/ng1963
| Summary | Full Text (HTML / PDF) |

article
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Rotem Karni, Elisa de Stanchina, Scott W Lowe, Rahul Sinha, David Mu & Adrian R Krainer
Nature Structural & Molecular Biology 14, 185–193
(March 2007); doi:10.1038/nsmb1209
| Summary | Full Text (HTML / PDF) |

news and views
Splicing oncogenes
Anchang Hu & Xiang-Dong Fu
Nature Structural & Molecular Biology 14, 174–175
(March 2007); doi:10.1038/nsmb0307-174
| Summary | Full Text (HTML / PDF) |

letter
A recurrent mutation in PALB2 in Finnish cancer families
Hannele Erkko, Bing Xia, Jenni Nikkilä, Johanna Schleutker, Kirsi Syrjäkoski, Arto Mannermaa, Anne Kallioniemi, Katri Pylkäs, Sanna-Maria Karppinen, Katrin Rapakko, Alexander Miron, Qing Sheng, Guilan Li, Henna Mattila, Daphne W. Bell, Daniel A. Haber, Mervi Grip, Mervi Reiman, Arja Jukkola-Vuorinen, Aki Mustonen, Juha Kere, Lauri A. Aaltonen, Veli-Matti Kosma, Vesa Kataja, Ylermi Soini, Ronny I. Drapkin, David M. Livingston and Robert Winqvist
Nature 446, 316–319
(15 March 2007); doi:10.1038/nature05609
| Summary | Full Text (HTML / PDF) |

letter
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar, Seong-il Lee, Sricharan Bandhakavi, Timothy J. Griffin & Do-Hyung Kim
Nature Cell Biology 9, 316–323
(March 2007); doi:10.1038/ncb1547
| Summary | Full Text (HTML / PDF) |

letter
A common coding variant in CASP8 is associated with breast cancer risk
Angela Cox et al.
Nature Genetics 39, 352 - 358
(March 2007); doi:10.1038/ng1981
| Summary | Full Text (HTML / PDF) |

letter
High-throughput oncogene mutation profiling in human cancer
Roman K Thomas et al.
Nature Genetics 39, 347 - 351
(March 2007); doi:10.1038/ng1975
| Summary | Full Text (HTML / PDF) |

news and views
The devil is in the DNA
Stephen J Chanock & Gilles Thomas
Nature Genetics 39, 283 - 284
(March 2007); doi:10.1038/ng0307-283
| Summary | Full Text (HTML / PDF) |

article
Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility
Mingxuan Xia & Hartmut Land
Nature Biotechnology 14, 215 - 223
(March 2007); doi:10.1038/nsmb1208
| Summary | Full Text (HTML / PDF) |

article
Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al.
Nature 446, 153–158
(8 March 2007); doi:10.1038/nature05610
| Summary | Full Text (HTML / PDF) |

news and views
Cancer: Drivers and passengers
Daniel A. Haber and Jeff Settleman
Nature 446, 145–146
(8 March 2007); doi:10.1038/446145a
| Summary | Full Text (HTML / PDF) |

news and views
Cell biology: Aneuploidy and cancer
David Pellman
Nature 446, 38–39
(1 March 2007); doi:10.1038/446038a
| Full Text (HTML / PDF) |

perspective
Darwinian medicine: a case for cancer
Mel Greaves
Nature Reviews Cancer 7, 213–221
(March 2007); doi:10.1038/nrc2071
| Summary | Full Text (HTML / PDF) |

February

brief communication arising
Bone Metastasis: Can osteoclasts be excluded?
T. John Martin and Gregory R. Mundy
Nature 445, E19
(22 February 2007); doi:10.1038/nature05657
| Summary | Full Text (HTML / PDF) |

brief communication arising
Bone Metastasis: Can osteoclasts be excluded? (Reply)
D. Holstead Jones, Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki, Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger
Nature 445, E19
(22 February 2007); doi:10.1038/nature05658
| Summary | Full Text (HTML / PDF) |

review
Myelodysplastic syndromes: the complexity of stem-cell diseases
Seth J. Corey, Mark D. Minden, Dwayne L. Barber, Hagop Kantarjian, Jean C. Y. Wang and Aaron D. Schimmer
Nature Reviews Cancer 7, 118–129
(February 2007); doi:10.1038/nrc2047
| Summary | Full Text (HTML / PDF) |

article
PTEN-deficient intestinal stem cells initiate intestinal polyposis
Xi C He, Tong Yin, Justin C Grindley, Qiang Tian, Toshiro Sato, W Andy Tao, Raminarao Dirisina, Kimberly S Porter-Westpfahl, Mark Hembree, Teri Johnson, Leanne M Wiedemann, Terrence A Barrett, Leroy Hood, Hong Wu & Linheng Li
Nature Genetics 39, 189–198
(February 2007); doi:10.1038/ng1928
| Summary | Full Text (HTML / PDF) |

letter
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
Yuichi Wakabayashi, Jian-Hua Mao, Ken Brown, Michael Girardi and Allan Balmain
Nature 445, 761–765
(15 February 2007); doi:10.1038/nature05489
| First Paragraph | Full Text (HTML / PDF) |

news and views
Vascular Biology: Vessel guidance
Thomas Gridley
Nature 445, 722–723
(15 February 2007); doi:10.1038/445722a
| Summary | Full Text (HTML / PDF) |

letter
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
Abderrahmane Kaidi, Ann Caroline Williams & Christos Paraskeva
Nature Cell Biology 9, 210–217
(February 2007); doi:10.1038/ncb1534
| First Paragraph | Full Text (HTML / PDF) |

brief communication
Epigenetic stem cell signature in cancer
Martin Widschwendter, Heidi Fiegl, Daniel Egle, Elisabeth Mueller-Holzner, Gilbert Spizzo, Christian Marth, Daniel J Weisenberger, Mihaela Campan, Joanne Young, Ian Jacobs & Peter W Laird
Nature Genetics 39, 157–158
(February 2007); doi:10.1038/ng1941
| Summary | Full Text (HTML / PDF) |

brief communication
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
Sarah Reid, Detlev Schindler, Helmut Hanenberg, Karen Barker, Sandra Hanks, Reinhard Kalb, Kornelia Neveling, Patrick Kelly, Sheila Seal, Marcel Freund, Melanie Wurm, Sat Dev Batish, Francis P Lach, Sevgi Yetgin, Heidemarie Neitzel, Hany Ariffin, Marc Tischkowitz, Christopher G Mathew, Arleen D Auerbach & Nazneen Rahman
Nature Genetics 39, 162–164
(February 2007); doi:10.1038/ng1947
| Summary | Full Text (HTML / PDF) |

brief communication
Fanconi anemia and breast cancer susceptibility
Ketan J Patel
Nature Genetics 39, 142–143
(February 2007); doi:10.1038/ng0207-142
| Summary | Full Text (HTML / PDF) |

letter
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin, David A. Tuveson, Jan Grimm, Laura Lintault, Jamie Newman, Elizabeth E. Reczek, Ralph Weissleder and Tyler Jacks
Nature 445, 661–665
(8 February 2007); doi:10.1038/nature05541
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cancer biology: Gone but not forgotten
Norman E. Sharpless and Ronald A. DePinho
Nature 445, 606–607
(8 February 2007); doi:10.1038/nature05567
| Summary | Full Text (HTML / PDF) |

review
G-protein-coupled receptors and cancer
Robert T. Dorsam and J. Silvio Gutkind
Nature Reviews Cancer 7, 79–94
(February 2007); doi:10.1038/nrc2069
| Summary | Full Text (HTML / PDF) |

perspective
The tumour microenvironment as a target for chemoprevention
Adriana Albini and Michael B. Sporn
Nature Reviews Cancer 7,
(February 2007); doi:10.1038/nrc2067
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perspective
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
Paul A Marks & Ronald Breslow
Nature Biotechnology 25, 84–90
(February 2007); doi:10.1038/nbt1272
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perspective
Why is cancer drug discovery so difficult?
Alexander Kamb, Susan Wee and Christoph Lengauer
Nature Reviews Drug Discovery 6, 115–120
(February 2007); doi:10.1038/nrd2155
| Summary | Full Text (HTML / PDF) |

January

letter
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
Natalia V. Sergina, Megan Rausch, Donghui Wang, Jimmy Blair, Byron Hann, Kevan M. Shokat and Mark M. Moasser
Nature 445, 437–441
(25 January 2007); doi:10.1038/nature05474
| First Paragraph | Full Text (HTML / PDF) |

article
NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
Bae Keun Park, Honglai Zhang, Qinghua Zeng, Jinlu Dai, Evan T Keller, Thomas Giordano, Keni Gu, Veena Shah, Lei Pei, Richard J Zarbo, Laurie McCauley, Songtao Shi, Shaoqiong Chen & Cun-Yu Wang
Nature Medicine 13, 62–69
(January 2007); doi:10.1038/nm1519
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article
Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid, Antoine Tesniere, François Ghiringhelli, Gian Maria Fimia, Lionel Apetoh, Jean-Luc Perfettini, Maria Castedo, Grégoire Mignot, Theoharis Panaretakis, Noelia Casares, Didier Métivier, Nathanael Larochette, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini, Laurence Zitvogel & Guido Kroemer
Nature Medicine 13, 54–61
(January 2007); doi:10.1038/nm1523
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perspective
The Connectivity Map: a new tool for biomedical research
Justin Lamb
Nature Reviews Cancer 7, 54–60
(January 2007); doi:10.1038/nrc2044
| Summary | Full Text (HTML / PDF) |

article
Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia
Tomas Vilimas, Joaquina Mascarenhas, Teresa Palomero, Malay Mandal, Silvia Buonamici, Fanyong Meng, Benjamín Thompson, Christina Spaulding, Sami Macaroun, Maria-Luisa Alegre, Barbara L Kee, Adolfo Ferrando, Lucio Miele & Iannis Aifantis
Nature Medicine 13, 70–77
(January 2007); doi:10.1038/nm1524
| Summary | Full Text (HTML / PDF) |

opinion
Chemoprevention of breast cancer with selective oestrogen-receptor modulators
V. Craig Jordan
Nature Reviews Cancer 7, 46–53
(January 2007); doi:10.1038/nrc2048
| Summary | Full Text (HTML / PDF) |

review
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Hua Yu, Marcin Kortylewski and Drew Pardoll
Nature Reviews Immunology 7, 41–51
(January 2007); doi:10.1038/nri1995
| Summary | Full Text (HTML / PDF) |

review
Cancer phenomics: RET and PTEN as illustrative models
Kevin M. Zbuk and Charis Eng
Nature Reviews Cancer 7, 35–45
(January 2007); doi:10.1038/nrc2037
| Summary | Full Text (HTML / PDF) |

letter
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
Naoko Shima, Ana Alcaraz, Ivan Liachko, Tavanna R Buske, Catherine A Andrews, Robert J Munroe, Suzanne A Hartford, Bik K Tye & John C Schiment
Nature Genetics 39, 93–98
(January 2007); doi:10.1038/ng1936
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news and views
Chaotic license for genetic instability and cancer
Anindya Dutta
Nature Genetics 39, 10–11
(January 2007); doi:10.1038/ng0107-10
| Summary | Full Text (HTML / PDF) |

letter
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
Catherine A. O'Brien, Aaron Pollett, Steven Gallinger and John E. Dick
Nature 445, 106–110
(4 January 2007); doi:10.1038/nature05372
| First Paragraph | Full Text (HTML / PDF) |

letter
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani, Dario G. Lombardi, Emanuela Pilozzi, Mauro Biffoni, Matilde Todaro, Cesare Peschle and Ruggero De Maria
Nature 445, 111–115
(4 January 2007); doi:10.1038/nature05384
| First Paragraph | Full Text (HTML / PDF) |

review
Computational prediction of cancer-gene function
Pingzhao Hu, Gary Bader, Dennis A. Wigle and Andrew Emili
Nature Reviews Cancer 7, 23–34
(January 2007); doi:10.1038/nrc2036
| Summary | Full Text (HTML / PDF) |

letter
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Aaheli Roy Choudhury, Zhenyu Ju, Meta W Djojosubroto, Andrea Schienke, Andre Lechel, Sonja Schaetzlein, Hong Jiang, Anna Stepczynska, Chunfang Wang, Jan Buer, Han-Woong Lee, Thomas von Zglinicki, Arnold Ganser, Peter Schirmacher, Hiromitsu Nakauchi & K Lenhard Rudolph
Nature Genetics 39, 99–105
(January 2007); doi:10.1038/ng1937
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news and views
Telomeres, p21 and the cancer-aging hypothesis
Jessica F Bell & Norman E Sharpless
Nature Genetics 39, 11–12
(January 2007); doi:10.1038/ng0107-11
| Summary | Full Text (HTML / PDF) |

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