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Research library: Cancer

2008: | July | June | May | April | March | February | January

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article
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
Irene García-Higuera et al.
Nature Cell Biology 10, 802–811
(July 2008); doi:10.1038/ncb1742
| Summary | Full Text (HTML / PDF) |

news and views
Cdh1: a master G0/G1 regulator
Jeffrey R. Skaar & Michele Pagano
Nature Cell Biology 10, 755–757
(July 2008); doi:10.1038/ncb0708-755
| Full Text (HTML / PDF) |

perspective
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
David R. Croucher, Darren N. Saunders, Sergei Lobov & Marie Ranson
Nature Reviews Cancer 8, 535–545
(July 2008); doi:10.1038/nrc2400
| Summary | Full Text (HTML / PDF) |

letter
IRF4 addiction in multiple myeloma
Arthur L. Shaffer et al.
Nature 454, 226–231
(10 July 2008); doi:10.1038/nature07064
| Summary | Full Text (HTML / PDF) |

review
Ras oncogenes: split personalities
Antoine E. Karnoub & Robert A. Weinberg
Nature Reviews Molecular Cell Biology 9, 517–531
(July 2008); doi:10.1038/nrm2438
| Summary | Full Text (HTML / PDF) |

review
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
Nature Reviews Cancer 8, 512–522
(July 2008); doi:10.1038/nrc2440
| Summary | Full Text (HTML / PDF) |

review
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Roberto Cattaneo, Tanner Miest, Elena V. Shashkova & Michael A. Barry
Nature Reviews Microbiology 6, 529–540
(July 2008); doi:10.1038/nrmicro1927
| Summary | Full Text (HTML / PDF) |

review
MYB function in normal and cancer cells
Robert G. Ramsay & Thomas J. Gonda
Nature Reviews Cancer 8, 523–534
(July 2008); doi:10.1038/nrc2439
| Summary | Full Text (HTML / PDF) |

letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
| Summary | Full Text (HTML / PDF) |

article
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
Alessia Montagnoli et al.
Nature Chemical Biology 4, 357–365
(June 2008); doi:10.1038/nchembio.90
| Summary | Full Text (HTML / PDF) |

news and views
Stopping replication, at the beginning
Peter K Jackson
Nature Chemical Biology 4, 331–332
(June 2008); doi:10.1038/nchembio0608-331
| Full Text (HTML / PDF) |

article
PML targeting eradicates quiescent leukaemia-initiating cells
Keisuke Ito et al.
Nature 453, 1072–1078
(19 June 2008); doi:10.1038/nature07016
| Summary | Full Text (HTML / PDF) |

letter
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
Helene R. McMurray et al.
Nature 453, 1112–1116
(19 June 2008); doi:10.1038/nature06973
| Summary | Full Text (HTML / PDF) |

news and views
Cancer: Deconstructing oncogenesis
Ji Luo & Stephen J. Elledge
Nature 453, 995–996
(19 June 2008); doi:10.1038/453995a
| Full Text (HTML / PDF) |

article
The type I TGF-β receptor is covalently modified and regulated by sumoylation
Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst & Rik Derynck
Nature Cell Biology 10, 654–664
(June 2008); doi:10.1038/ncb1728
| Summary | Full Text (HTML / PDF) |

news and views
SUMO amplifies TGF-β signalling
Kohei Miyazono, Yuto Kamiya & Keiji Miyazawa
Nature Cell Biology 10, 635–637
(June 2008); doi:10.1038/ncb0608-635
| Full Text (HTML / PDF) |

review
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao & Benjamin Moeller
Nature Reviews Cancer 8, 425–437
(June 2008); doi:10.1038/nrc2397
| Summary | Full Text (HTML / PDF) |

perspective
The Mouse Tumor Biology database
Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult & Janan T. Eppig
Nature Reviews Cancer 8, 459–465
(June 2008); doi:10.1038/nrc2390
| Summary | Full Text (HTML / PDF) |

review
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Paolo M. Comoglio, Silvia Giordano & Livio Trusolino
Nature Reviews Drug Discovery 7, 504–516
(June 2008); doi:10.1038/nrd2530
| Summary | Full Text (HTML / PDF) |

review
Inhibitory B7-family molecules in the tumour microenvironment
Weiping Zou & Lieping Chen
Nature Reviews Immunology 8, 467–477
(June 2008); doi:10.1038/nri2326
| Summary | Full Text (HTML / PDF) |

review
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
David Frescas & Michele Pagano
Nature Reviews Cancer 8, 438–449
(June 2008); doi:10.1038/nrc2396
| Summary | Full Text (HTML / PDF) |

letter
p53 regulates glucose metabolism through an IKK–NF-κB pathway and inhibits cell transformation
Keiko Kawauchi, Keigo Araki, Kei Tobiume & Nobuyuki Tanaka
Nature Cell Biology 10, 611–618
(May 2008); doi:10.1038/ncb1724
| Summary | Full Text (HTML / PDF) |

review
Molecular pathogenesis of T-cell leukaemia and lymphoma
Iannis Aifantis, Elizabeth Raetz & Silvia Buonamici
Nature Reviews Immunology 8, 380–390
(May 2008); doi:10.1038/nri2304
| Summary | Full Text (HTML / PDF) |

perspective
Wnt signalling and its impact on development and cancer
Alexandra Klaus & Walter Birchmeier
Nature Reviews Cancer 8, 387–398
(May 2008); doi:10.1038/nrc2389
| Summary | Full Text (HTML / PDF) |

letter
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Philip A. Gregory et al.
Nature Cell Biology 10, 593–601
(May 2008); doi:10.1038/ncb1722
| Summary | Full Text (HTML / PDF) |

news and views
MicroRNAs — keeping cells in formation
Eric A. Miska
Nature Cell Biology 10, 501–502
(May 2008); doi:10.1038/ncb0508-501
| Full Text (HTML / PDF) |

review
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Klaus Pantel, Ruud H. Brakenhoff & Burkhard Brandt
Nature Reviews Cancer 8, 329–340
(May 2008); doi:10.1038/nrc2375
| Summary | Full Text (HTML / PDF) |

letter
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Kevin M Haigis et al.
Nature Genetics 40, 600–608
(May 2008); doi:10.1038/ng.115
| Summary | Full Text (HTML / PDF) |

letter
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah et al.
Nature 453, 410–414
(15 May 2008); doi:10.1038/nature06868
| Summary | Full Text (HTML / PDF) |

article
Stromal gene expression predicts clinical outcome in breast cancer
Greg Finak et al.
Nature Medicine 14, 518–527
(May 2008); doi:10.1038/nm1764
| Summary | Full Text (HTML / PDF) |

review
Getting to the stem of chronic myeloid leukaemia
Michael Savona & Moshe Talpaz
Nature Reviews Cancer 8, 341–350
(May 2008); doi:10.1038/nrc2368
| Summary | Full Text (HTML / PDF) |

article
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Michael H. Tatham et al.
Nature Cell Biology 10, 538–546
(May 2008); doi:10.1038/ncb1716
| Summary | Full Text (HTML / PDF) |

article
Arsenic degrades PML or PML-RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway
Valérie Lallemand-Breitenbach et al.
Nature Cell Biology 10, 547–555
(May 2008); doi:10.1038/ncb1717
| Summary | Full Text (HTML / PDF) |

news and views
Marked for death
Kevin Petrie & Arthur Zelent
Nature Cell Biology 10, 507–509
(May 2008); doi:10.1038/ncb0508-507
| Full Text (HTML / PDF) |

review
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
H. Llewelyn Roderick & Simon J. Cook
Nature Reviews Cancer 8, 361–375
(May 2008); doi:10.1038/nrc2374
| Summary | Full Text (HTML / PDF) |

letter
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
Wen Qiu et al.
Nature Genetics 40, 650–655
(May 2008); doi:10.1038/ng.117
| Summary | Full Text (HTML / PDF) |

news and views
Coevolution in the tumor microenvironment
Robert A Weinberg
Nature Genetics 40, 494–495
(May 2008); doi:10.1038/ng0508-494
| Summary | Full Text (HTML / PDF) |

letter
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
Nature 453, 110–114
(1 May 2008); doi:10.1038/nature06866
| Summary | Full Text (HTML / PDF) |

letter
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Khalid Al-Nedawi et al.
Nature Cell Biology 10, 619–624
(May 2008); doi:10.1038/ncb1725
| Summary | Full Text (HTML / PDF) |

perspective
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
John M. Pawelek & Ashok K. Chakraborty
Nature Reviews Cancer 8, 377–386
(May 2008); doi:10.1038/nrc2371
| Summary | Full Text (HTML / PDF) |

analysis
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
Ittai Ben-Porath et al.
Nature Genetics 40, 499–507
(May 2008); doi:10.1038/ng.127
| Summary | Full Text (HTML / PDF) |

review
GATA1-related leukaemias
Ritsuko Shimizu, James Douglas Engel & Masayuki Yamamoto
Nature Reviews Cancer 8, 279–287
(April 2008); doi:10.1038/nrc2348
| Summary | Full Text (HTML / PDF) |

article
MicroRNAs accurately identify cancer tissue origin
Nitzan Rosenfeld et al.
Nature Biotechnology 26, 462–469
(April 2008); doi:10.1038/nbt1392
| Summary | Full Text (HTML / PDF) |

news and views
Cancer biomarker profiling with microRNAs
Stefanie S Jeffrey
Nature Biotechnology 26, 400–401
(April 2008); doi:10.1038/nbt0408-400
| Summary | Full Text (HTML / PDF) |

review
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Isabel M. Chu, Ludger Hengst & Joyce M. Slingerland
Nature Reviews Cancer 8, 253–267
(April 2008); doi:10.1038/nrc2347
| Summary | Full Text (HTML / PDF) |

article
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Pekka Katajisto et al.
Nature Genetics 40, 455–459
(April 2008); doi:10.1038/ng.98
| Summary | Full Text (HTML / PDF) |

perspective
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Rakesh K. Jain
Nature Reviews Cancer 8, 309–316
(April 2008); doi:10.1038/nrc2346
| Summary | Full Text (HTML / PDF) |

letter
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
Nature 452, 646–649
(3 April 2008); doi:10.1038/nature06778
| Summary | Full Text (HTML / PDF) |

letter
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
Ilaria Malanchi et al.
Nature 452, 650–653
(3 April 2008); doi:10.1038/nature06835
| Summary | Full Text (HTML / PDF) |

review
The cancer biomarker problem
Charles L. Sawyers
Nature 452, 548–552
(3 April 2008); doi:10.1038/nature06913
| Summary | Full Text (HTML / PDF) |

review
Translating insights from the cancer genome into clinical practice
Lynda Chin & Joe W. Gray
Nature 452, 553–552
(3 April 2008); doi:10.1038/nature06914
| Summary | Full Text (HTML / PDF) |

review
Enabling personalized cancer medicine through analysis of gene-expression patterns
Laura J. van't Veer & René Bernards
Nature 452, 564–570
(3 April 2008); doi:10.1038/nature06915
| Summary | Full Text (HTML / PDF) |

review
Mining the plasma proteome for cancer biomarkers
Samir M. Hanash, Sharon J. Pitteri & Vitor M. Faca
Nature 452, 571–579
(3 April 2008); doi:10.1038/nature06916
| Summary | Full Text (HTML / PDF) |

review
Imaging in the era of molecular oncology
Ralph Weissleder & Mikael J. Pittet
Nature 452, 580–589
(3 April 2008); doi:10.1038/nature06917
| Summary | Full Text (HTML / PDF) |

review
Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability
Robert G. Bristow & Richard P. Hill
Nature Reviews Cancer 8, 180–192
(March 2008); doi:10.1038/nrc2344
| Summary | Full Text (HTML / PDF) |

review
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
Akeila Bellahcène, Vincent Castronovo, Kalu U. E. Ogbureke, Larry W. Fisher & Neal S. Fedarko
Nature Reviews Cancer 8, 212–226
(March 2008); doi:10.1038/nrc2345
| Summary | Full Text (HTML / PDF) |

review
Interleukin 21: combination strategies for cancer therapy
Kresten Skak, Michael Kragh, Diana Hausman, Mark J. Smyth & Pallavur V. Sivakumar
Nature Reviews Drug Discovery 7, 231–240
(March 2008); doi:10.1038/nrd2482
| Summary | Full Text (HTML / PDF) |

article
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara & Lewis C. Cantley
Nature 452, 181–186
(13 March 2008); doi:10.1038/nature06667
| Summary | Full Text (HTML / PDF) |

letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230–233
(13 March 2008); doi:10.1038/nature06734
| Summary | Full Text (HTML / PDF) |

article
SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
Hye-Jung Han, Jose Russo, Yoshinori Kohwi & Terumi Kohwi-Shigematsu
Nature 452, 187–193
(13 March 2008); doi:10.1038/nature06781
| Summary | Full Text (HTML / PDF) |

article
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang et al.
Nature Cell Biology 10, 295–305
(March 2008); doi:10.1038/ncb1691
| Summary | Full Text (HTML / PDF) |

news and views
A hypoxic twist in metastasis
Héctor Peinado & Amparo Cano
Nature Cell Biology 10, 253–254
(March 2008); doi:10.1038/ncb0308-253
| Full Text (HTML / PDF) |

review
DNA repair pathways as targets for cancer therapy
Thomas Helleday, Eva Petermann, Cecilia Lundin, Ben Hodgson & Ricky A. Sharma
Nature Reviews Cancer 8, 193–204
(March 2008); doi:10.1038/nrc2342
| Summary | Full Text (HTML / PDF) |

perspective
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
Fiona M. Watt, Michaela Frye & Salvador Aznar Benitah
Nature Reviews Cancer 8, 234–242
(March 2008); doi:10.1038/nrc2328
| Summary | Full Text (HTML / PDF) |

brief communication
Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene
Aytekin Akyol, Takao Hinoi, Ying Feng, Guido T Bommer, Thomas M Glaser & Eric R Fearon
Nature Methods 5, 231–233
(March 2008); doi:10.1038/nmeth.1182
| Summary | Full Text (HTML / PDF) |

news and views
Harnessing mismatch repair to model sporadic cancers
Richard Fishel & Joanna Groden
Nature Methods 5, 225–226
(March 2008); doi:10.1038/nmeth0308-225
| Summary | Full Text (HTML / PDF) |

letter
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
Nature 451, 1111–1115
(28 February 2008); doi:10.1038/nature06548
| Summary | Full Text (HTML / PDF) |

letter
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai et al.
Nature 451, 1116–1120
(28 February 2008); doi:10.1038/nature06633
| Summary | Full Text (HTML / PDF) |

news and views
Cancer: Crossing over to drug resistance
David M. Livingston & Daniel P. Silver
Nature 451, 1066–1067
(28 February 2008); doi:10.1038/4511066a
| Full Text (HTML / PDF) |

article
TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
Jiong Li & Cun-Yu Wang
Nature Cell Biology 10, 160–169
(February 2008); doi:10.1038/ncb1684
| Summary | Full Text (HTML / PDF) |

perspective
Is cell competition relevant to cancer?
Eduardo Moreno
Nature Reviews Cancer 8, 141–147
(February 2008); doi:10.1038/nrc2252
| Summary | Full Text (HTML / PDF) |

brief communication
A secreted luciferase for ex vivo monitoring of in vivo processes
Thomas Wurdinger et al.
Nature Methods 5, 171–173
(February 2008); doi:10.1038/nmeth.1177
| Summary | Full Text (HTML / PDF) |

review
Ral GTPases and cancer: linchpin support of the tumorigenic platform
Brian O. Bodemann & Michael A. White
Nature Reviews Cancer 8, 133–140
(February 2008); doi:10.1038/nrc2296
| Summary | Full Text (HTML / PDF) |

article
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
Nature Cell Biology 10, 138–148
(February 2008); doi:10.1038/ncb1676
| Summary | Full Text (HTML / PDF) |

news and views
ERK and MDM2 prey on FOXO3a
Wensheng Yang, Nathan G. Dolloff & Wafik S. El-Deiry
Nature Cell Biology 10, 125–126
(February 2008); doi:10.1038/ncb0208-125
| Summary | Full Text (HTML / PDF) |

letter
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Qihong Huang et al.
Nature Cell Biology 10, 202–210
(February 2008); doi:10.1038/ncb1681
| Summary | Full Text (HTML / PDF) |

review
New approaches for imaging tumour responses to treatment
Kevin Brindle
Nature Reviews Cancer 8, 94–107
(February 2008); doi:10.1038/nrc2289
| Summary | Full Text (HTML / PDF) |

article
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
Sophie Pinner & Erik Sahai
Nature Cell Biology 10, 127–137
(February 2008); doi:10.1038/ncb1675
| Summary | Full Text (HTML / PDF) |

article
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
Jessica Strid et al.
Nature Immunology 9, 146–154
(February 2008); doi:10.1038/ni1556
| Summary | Full Text (HTML / PDF) |

news and views
Stress gets under your skin
Daniel M Andrews & Mark J Smyth
Nature Immunology 9, 119–120
(February 2008); doi:10.1038/ni0208-119
| Full Text (HTML / PDF) |

review
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
Anthony G. Letai
Nature Reviews Cancer 8, 121–132
(February 2008); doi:10.1038/nrc2297
| Summary | Full Text (HTML / PDF) |

review
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
Markus Welcker & Bruce E. Clurman
Nature Reviews Cancer 8, 83–93
(February 2008); doi:10.1038/nrc2290
| Summary | Full Text (HTML / PDF) |

brief communication
Site selectivity of platinum anticancer therapeutics
Bin Wu, Peter Dröge & Curt A Davey
Nature Chemical Biology 4, 110–112
(February 2008); doi:10.1038/nchembio.2007.58
| Summary | Full Text (HTML / PDF) |

review
The anaplastic lymphoma kinase in the pathogenesis of cancer
Roberto Chiarle, Claudia Voena, Chiara Ambrogio, Roberto Piva & Giorgio Inghirami
Nature Reviews Cancer 8, 11–23
(January 2008); doi:10.1038/nrc2291
| Summary | Full Text (HTML / PDF) |

article
Widespread microRNA repression by Myc contributes to tumorigenesis
Tsung-Cheng Chang et al.
Nature Genetics 40, 43–50
(January 2008); doi:10.1038/ng.2007.30
| Summary | Full Text (HTML / PDF) |

article
Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo
Erik Henke et al.
Nature Biotechnology 26, 91–100
(January 2008); doi:10.1038/nbt1366
| Summary | Full Text (HTML / PDF) |

letter
Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345–349
(17 January 2008); doi:10.1038/nature06489
| Summary | Full Text (HTML / PDF) |

perspective
The interplay between MYC and HIF in cancer
Chi V. Dang, Jung-whan Kim, Ping Gao & Jason Yustein
Nature Reviews Cancer 8, 51–56
(January 2008); doi:10.1038/nrc2274
| Summary | Full Text (HTML / PDF) |

letter
AID is required for germinal center-derived lymphomagenesis
Laura Pasqualucci et al.
Nature Genetics 40, 108–112
(January 2008); doi:10.1038/ng.2007.35
| Summary | Full Text (HTML / PDF) |

perspective
The emerging landscape of breast cancer susceptibility
Michael R Stratton & Nazneen Rahman
Nature Genetics 40, 17–22
(January 2008); doi:10.1038/ng.2007.53
| Summary | Full Text (HTML / PDF) |

article
Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F. Tavazoie et al.
Nature 451, 147–152
(10 January 2008); doi:10.1038/nature06487
| Summary | Full Text (HTML / PDF) |

letter
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu et al.
Nature 451, 202–206
(10 January 2008); doi:10.1038/nature06468
| Summary | Full Text (HTML / PDF) |

letter
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
Masaki Morishige et al.
Nature Cell Biology 10, 85–92
(January 2008); doi:10.1038/ncb1672
| Summary | Full Text (HTML / PDF) |

news and views
Getting invasive with GEP100 and Arf6
Ferran Valderrama & Anne J. Ridley
Nature Cell Biology 10, 16–18
(January 2008); doi:10.1038/ncb0108-16
| Summary | Full Text (HTML / PDF) |

article
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
Ronald J Buckanovich et al.
Nature Medicine 14, 28–36
(January 2008); doi:10.1038/nm1699
| Summary | Full Text (HTML / PDF) |

news and views
Opening the gateway to tumors
Michael H Kershaw
Nature Medicine 14, 13–14
(January 2008); doi:10.1038/nm0108-13
| Summary | Full Text (HTML / PDF) |

letter
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
Lao H Saal et al.
Nature Genetics 40, 102–107
(January 2008); doi:10.1038/ng.2007.39
| Summary | Full Text (HTML / PDF) |

news and views
BRCA1—sowing the seeds crooked in the furrow
William D Foulkes
Nature Genetics 40, 8–9
(January 2008); doi:10.1038/ng0108-8
| Full Text (HTML / PDF) |

letter
Trisomy represses ApcMin-mediated tumours in mouse models of Down's syndrome
Thomas E. Sussan, Annan Yang, Fu Li, Michael C. Ostrowski & Roger H. Reeves
Nature 451, 73–75
(3 January 2008); doi:10.1038/nature06446
| Summary | Full Text (HTML / PDF) |

letter
NUMB controls p53 tumour suppressor activity
Ivan N. Colaluca et al.
Nature 451, 76–80
(3 January 2008); doi:10.1038/nature06412
| Summary | Full Text (HTML / PDF) |

review
Immunological aspects of cancer chemotherapy
Laurence Zitvogel, Lionel Apetoh, François Ghiringhelli & Guido Kroemer
Nature Reviews Immunology 8, 59–73
(January 2008); doi:10.1038/nri2216
| Summary | Full Text (HTML / PDF) |

perspective
Survivin, cancer networks and pathway-directed drug discovery
Dario C. Altieri
Nature Reviews Cancer 8, 61–70
(January 2008); doi:10.1038/nrc2293
| Summary | Full Text (HTML / PDF) |

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