Research library: Cancer
2008:
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December
letter
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
Maria Barna et al.
Nature 456, 971–975
(18 December 2008); doi:10.1038/nature07449
| Summary | Full Text (HTML / PDF) |
article
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Rihab Nasr et al.
Nature Medicine 14, 1333–1342
(December 2008); doi:10.1038/nm.1891
| Summary | Full Text (HTML / PDF) |
letter
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A Engelman et al.
Nature Medicine 14, 1351–1356
(December 2008); doi:10.1038/nm.1890
| Summary | Full Text (HTML / PDF) |
news and views
Targeting RAS and PI3K in lung cancer
Julian Downward
Nature Medicine 14, 1315–1316
(December 2008); doi:10.1038/nm1208-1315
| Full Text (HTML / PDF) |
review
The ADAMs: signalling scissors in the tumour microenvironment
Gillian Murphy
Nature Reviews Cancer 8, 932–941
(December 2008); doi:10.1038/nrc2459
| Summary | Full Text (HTML / PDF) |
perspective
The genetics of the p53 pathway, apoptosis and cancer therapy
Alexei Vazquez, Elisabeth E. Bond, Arnold J. Levine & Gareth L. Bond
Nature Reviews Drug Discovery 7, 979–987
(December 2008); doi:10.1038/nrd2656
| Summary | Full Text (HTML / PDF) |
letter
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Joshua I. Greenberg et al.
Nature 456, 809–813
(11 December 2008); doi:10.1038/nature07424
| Summary | Full Text (HTML / PDF) |
letter
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Christian Stockmann et al.
Nature 456, 814–818
(11 December 2008); doi:10.1038/nature07445
| Summary | Full Text (HTML / PDF) |
review
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
Christian Fischer, Massimiliano Mazzone, Bart Jonckx & Peter Carmeliet
Nature Reviews Cancer 8, 942–956
(December 2008); doi:10.1038/nrc2524
| Summary | Full Text (HTML / PDF) |
article
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
COGENT Study
Nature Genetics 40, 1426–1435
(December 2008); doi:10.1038/ng.262
| Summary | Full Text (HTML / PDF) |
review
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
Anwesha Dey, Vinay Tergaonkar & David P. Lane
Nature Reviews Drug Discovery 7, 1031–1040
(December 2008); doi:10.1038/nrd2759
| Summary | Full Text (HTML / PDF) |
review
Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
Avi Ashkenazi
Nature Reviews Drug Discovery 7, 1001–1012
(December 2008); doi:10.1038/nrd2637
| Summary | Full Text (HTML / PDF) |
review
The curious case of the tumour virus: 50 years of Burkitt's lymphoma
David A. Thorley-Lawson & Martin J. Allday
Nature Reviews Microbiology 6, 913–924
(December 2008); doi:10.1038/nrmicro2015
| Summary | Full Text (HTML / PDF) |
letter
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen
Antoni Hurtado et al.
Nature 456, 663–666
(04 December 2008); doi:10.1038/nature07483
| Summary | Full Text (HTML / PDF) |
letter
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
Allyson E. Vaughn & Mohanish Deshmukh
Nature Cell Biology 10, 1477–1483
(December 2008); doi:10.1038/ncb1807
| Summary | Full Text (HTML / PDF) |
perspective
Immunotherapy of autoimmunity and cancer: the penalty for success
Rachel R. Caspi
Nature Reviews Immunology 8, 970–976
(December 2008); doi:10.1038/nri2438
| Summary | Full Text (HTML / PDF) |
review
Insulin and insulin-like growth factor signalling in neoplasia
Michael Pollak
Nature Reviews Cancer 8, 915–928
(December 2008); doi:10.1038/nrc2536
| Summary | Full Text (HTML / PDF) |
article
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
Victoria Marsh et al.
Nature Genetics 40, 1436–1444
(December 2008); doi:10.1038/ng.256
| Summary | Full Text (HTML / PDF) |
review
BCL-2 family antagonists for cancer therapy
Guillaume Lessene, Peter E. Czabotar & Peter M. Colman
Nature Reviews Drug Discovery 7, 989–1000
(December 2008); doi:10.1038/nrd2658
| Summary | Full Text (HTML / PDF) |
November
letter
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase
Sachie Hiratsuka et al.
Nature Cell Biology 10, 1349–1355
(November 2008); doi:10.1038/ncb1794
| Summary | Full Text (HTML / PDF) |
article
5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Hendrik Poeck et al.
Nature Medicine 14, 1256–1263
(November 2008); doi:10.1038/nm.1887
| Summary | Full Text (HTML / PDF) |
news and views
RIG-ing an antitumor response
Fabio Petrocca & Judy Lieberman
Nature Medicine 14, 1152–1153
(November 2008); doi:10.1038/nm1108-1152
| Full Text (HTML / PDF) |
letter
The miR-15a—miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
Désirée Bonci et al.
Nature Medicine 14, 1271–1277
(November 2008); doi:10.1038/nm.1880
| Summary | Full Text (HTML / PDF) |
review
Derailed endocytosis: an emerging feature of cancer
Yaron Mosesson, Gordon B. Mills & Yosef Yarden
Nature Reviews Cancer 8, 835–850
(November 2008); doi:10.1038/nrc2521
| Summary | Full Text (HTML / PDF) |
perspective
Ageing, oxidative stress and cancer: paradigms in parallax
Christopher C. Benz & Christina Yau
Nature Reviews Cancer 8, 875–879
(November 2008); doi:10.1038/nrc2522
| Summary | Full Text (HTML / PDF) |
perspective
Cytokines and their relationship to the symptoms and outcome of cancer
Bostjan Seruga, Haibo Zhang, Lori J. Bernstein & Ian F. Tannock
Nature Reviews Cancer 8, 887–899
(November 2008); doi:10.1038/nrc2507
| Summary | Full Text (HTML / PDF) |
perspective
Turning anti-ageing genes against cancer
Valter D. Longo, Michael R. Lieber & Jan Vijg
Nature Reviews Molecular Cell Biology 9, 903–910
(November 2008); doi:10.1038/nrm2526
| Summary | Full Text (HTML / PDF) |
review
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
William G. Kaelin Jr
Nature Reviews Cancer 8, 865–873
(November 2008); doi:10.1038/nrc2502
| Summary | Full Text (HTML / PDF) |
article
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
Jin He, Eric M Kallin, Yu-ichi Tsukada & Yi Zhang
Nature Structural & Molecular Biology 15, 1169–1175
(November 2008); doi:10.1038/nsmb.1499
| Summary | Full Text (HTML / PDF) |
news and views
An INKlination for epigenetic control of senescence
Gordon Peters
Nature Structural & Molecular Biology 15, 1133–1134
(November 2008); doi:10.1038/nsmb1108-1133
| Full Text (HTML / PDF) |
article
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
Timothy J. Ley et al.
Nature 456, 66–72
(6 November 2008); doi:10.1038/nature07485
| Summary | Full Text (HTML / PDF) |
news and views
Human genetics: Individual genomes diversify
Samuel Levy & Robert L. Strausberg
Nature 456, 49–51
(November 2008); doi:10.1038/456049a
| Full Text (HTML / PDF) |
article
Modulation of the antitumor immune response by complement
Maciej M Markiewski et al.
Nature Immunology 9, 1225–1235
(November 2008); doi:10.1038/ni.1655
| Summary | Full Text (HTML / PDF) |
news and views
Cancer exploiting complement: a clue or an exception?
Bruce E Loveland & Jonathan Cebon
Nature Immunology 9, 1205–1206
(November 2008); doi:10.1038/ni1108-1205
| Full Text (HTML / PDF) |
review
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Bradly G. Wouters & Marianne Koritzinsky
Nature Reviews Cancer 8, 851–864
(November 2008); doi:10.1038/nrc2501
| Summary | Full Text (HTML / PDF) |
perspective
VEGF-A splicing: the key to anti-angiogenic therapeutics?
Steven J. Harper & David O. Bates
Nature Reviews Cancer 8, 880–887
(November 2008); doi:10.1038/nrc2505
| Summary | Full Text (HTML / PDF) |
October
article
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille & Michael L. Cleary
Nature 455, 1205–1209
(30 October 2008); doi:10.1038/nature07284
| Summary | Full Text (HTML / PDF) |
review
The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
Kay F. Macleod
Nature Reviews Cancer 8, 769–781
(October 2008); doi:10.1038/nrc2504
| Summary | Full Text (HTML / PDF) |
perspective
Replication licensing and cancer — a fatal entanglement?
J. Julian Blow & Peter J. Gillespie
Nature Reviews Cancer 8, 799–806
(October 2008); doi:10.1038/nrc2500
| Summary | Full Text (HTML / PDF) |
review
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer
Pascal Descargues, Alok K Sil and Michael Karin
The EMBO Journal 27, 2639–2647
(October 2008); doi:10.1038/emboj2008196a
| Summary | Full Text (HTML / PDF) |
article
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding et al.
Nature 455, 1069–1075
(23 October 2008); doi:10.1038/nature07423
| Summary | Full Text (HTML / PDF) |
article
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
The Cancer Genome Atlas Research Network
Nature 455, 1061–1068
(23 October 2008); doi:10.1038/nature07385
| Summary | Full Text (HTML / PDF) |
letter
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
Hongwu Zheng et al.
Nature 455, 1129–1133
(23 October 2008); doi:10.1038/nature07443
| Summary | Full Text (HTML / PDF) |
letter
Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL
Vipul C. Chitalia et al.
Nature Cell Biology 10, 1208–1216
(October 2008); doi:10.1038/ncb1781
| Summary | Full Text (HTML / PDF) |
news and views
One hit, two outcomes for VHL-mediated tumorigenesis
Jürgen Behrens
Nature Cell Biology 10, 1127–1128
(October 2008); doi:10.1038/ncb1008-1127
| Full Text (HTML / PDF) |
review
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Jane E. Visvader & Geoffrey J. Lindeman
Nature Reviews Cancer 8 755–768
(October 2008); doi:10.1038/nrc2499
| Summary | Full Text (HTML / PDF) |
letter
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
Minh D To, Christine E Wong, Anthony N Karnezis, Reyno Del Rosario, Roberto Di Lauro & Allan Balmain
Nature Genetics 40, 1240–1244
(October 2008); doi:10.1038/ng.211
| Summary | Full Text (HTML / PDF) |
news and views
Kras and Hras—what is the difference?
Anton Berns
Nature Genetics 40, 1149–1150
(October 2008); doi:10.1038/ng1008-1149
| Full Text (HTML / PDF) |
article
Identification of ALK as a major familial neuroblastoma predisposition gene
Yaël P. Mossé et al.
Nature 455, 930–935
(16 October 2008); doi:10.1038/nature07261
| Summary | Full Text (HTML / PDF) |
letter
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix-Lerosey et al.
Nature 455, 967–970
(16 October 2008); doi:10.1038/nature07398
| Summary | Full Text (HTML / PDF) |
letter
Oncogenic mutations of ALK kinase in neuroblastoma
Yuyan Chen et al.
Nature 455, 971–974
(16 October 2008); doi:10.1038/nature07399
| Summary | Full Text (HTML / PDF) |
letter
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George et al.
Nature 455, 975–978
(16 October 2008); doi:10.1038/nature07397
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: A ringleader identified
Charis Eng
Nature 455, 883–884
(16 October 2008); doi:10.1038/455883a
| Full Text (HTML / PDF) |
review
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Martin F. Lavin
Nature Reviews Molecular Cell Biology 9, 759–769
(October 2008); doi:10.1038/nrm2514
| Summary | Full Text (HTML / PDF) |
perspective
Bone morphogenetic protein signalling in colorectal cancer
James C. Hardwick, Liudmila L. Kodach, G. Johan Offerhaus & Gijs R. van den Brink
Nature Reviews Cancer 8, 806–812
(October 2008); doi:10.1038/nrc2467
| Summary | Full Text (HTML / PDF) |
review
Basal cell carcinomas: attack of the hedgehog
Ervin H. Epstein
Nature Reviews Cancer 8, 743–754
(October 2008); doi:10.1038/nrc2503
| Summary | Full Text (HTML / PDF) |
letter
Modelling Myc inhibition as a cancer therapy
Laura Soucek et al.
Nature 455, 679–683
(2 October 2008); doi:10.1038/nature07260
| Summary | Full Text (HTML / PDF) |
letter
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation
Valentina Gandin et al.
Nature 455, 684–688
(2 October 2008); doi:10.1038/nature07267
| Summary | Full Text (HTML / PDF) |
review
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Ricky W. Johnstone, Ailsa J. Frew & Mark J. Smyth
Nature Reviews Cancer 8, 782–798
(October 2008); doi:10.1038/nrc2465
| Summary | Full Text (HTML / PDF) |
September
letter
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein et al.
Nature 455, 547–551
(25 September 2008); doi:10.1038/nature07179
| Summary | Full Text (HTML / PDF) |
letter
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
Erick J. Morris et al.
Nature 455, 552–556
(25 September 2008); doi:10.1038/nature07310
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Entangled pathways
René Bernards
Nature 455, 479–480
(September 2008); doi:10.1038/455479a;
| Full Text (HTML / PDF) |
review
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Deborah L. Burkhart & Julien Sage
Nature Reviews Cancer 8, 671–682
(September 2008); doi:10.1038/nrc2399
| Summary | Full Text (HTML / PDF) |
review
Targeting of tetraspanin proteins — potential benefits and strategies
Martin E. Hemler
Nature Reviews Drug Discovery 7, 747–758
(September 2008); doi:10.1038/nrd2659
| Summary | Full Text (HTML / PDF) |
letter
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
Nature 455, 406–410
(18 September 2008); doi:10.1038/nature07275
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Hedgehog's other great trick
Tom Curran & Jessica M. Y. Ng
Nature 455, 293–294
(18 September 2008); doi:10.1038/455293a
| Full Text (HTML / PDF) |
perspective
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
Nature Reviews Cancer 8, 705–713
(September 2008); doi:10.1038/nrc2468
| Summary | Full Text (HTML / PDF) |
article
Cytosporone B is an agonist for nuclear orphan receptor Nur77
Yanyan Zhan et al.
Nature Chemical Biology 4, 548–556
(September 2008); doi:10.1038/nchembio.106
| Summary | Full Text (HTML / PDF) |
review
A new MAFia in cancer
Alain Eychène, Nathalie Rocques & Celio Pouponnot
Nature Reviews Cancer 8, 683–693
(September 2008); doi:10.1038/nrc2460
| Summary | Full Text (HTML / PDF) |
perspective
Tailoring to RB: tumour suppressor status and therapeutic response
Erik S. Knudsen & Karen E. Knudsen
Nature Reviews Cancer 8, 714–724
(September 2008); doi:10.1038/nrc2401
| Summary | Full Text (HTML / PDF) |
letter
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling
Steven Hoseong Yang et al.
Nature Genetics 40, 1130–1135
(September 2008); doi:10.1038/ng.192
| Summary | Full Text (HTML / PDF) |
news and views
Hedgehog in Wnterland
Dennis Roop & Rune Toftgård
Nature Genetics 40, 1040–1041
(September 2008); doi:10.1038/ng0908-1040
| Full Text (HTML / PDF) |
August
review
Cancer as an overhealing wound: an old hypothesis revisited
Matthias Schäfer & Sabine Werner
Nature Reviews Molecular Cell Biology 9, 628–638
(August 2008); doi:10.1038/nrm2455
| Summary | Full Text (HTML / PDF) |
review
Modes of resistance to anti-angiogenic therapy
Gabriele Bergers & Douglas Hanahan
Nature Reviews Cancer 8, 592–603
(August 2008); doi:10.1038/nrc2442
| Summary | Full Text (HTML / PDF) |
review
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
Gera Neufeld & Ofra Kessler
Nature Reviews Cancer 8, 632–645
(August 2008); doi:10.1038/nrc2404
| Summary | Full Text (HTML / PDF) |
article
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer
Vihren Kolev et al.
Nature Cell Biology 10, 902–911
(August 2008); doi:10.1038/ncb1750
| Summary | Full Text (HTML / PDF) |
article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath R Junutula et al.
Nature Biotechnology 26, 925–932
doi:10.1038/nbt.1480
| Summary | Full Text (HTML / PDF) |
news and views
Antibody-drug conjugates ace the tolerability test
Nitin K Damle
Nature Biotechnology 26, 884–885
(August 2008); doi:10.1038/nbt0808-884
| Full Text (HTML / PDF) |
letter
Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
Shidong Jia et al.
Nature 454, 776–779
(7 August 2008); doi:10.1038/nature07091
| Summary | Full Text (HTML / PDF) |
review
Integrins in angiogenesis and lymphangiogenesis
Christie J. Avraamides, Barbara Garmy-Susini & Judith A. Varner
Nature Reviews Cancer 8, 604–617
(August 2008); doi:10.1038/nrc2353
| Summary | Full Text (HTML / PDF) |
letter
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela et al.
Nature 454, 656–660
(31 July 2008); doi:10.1038/nature07083
| Summary | Full Text (HTML / PDF) |
review
VEGF-targeted therapy: mechanisms of anti-tumour activity
Lee M. Ellis & Daniel J. Hicklin
Nature Reviews Cancer 8, 579–591
(August 2008); doi:10.1038/nrc2403
| Summary | Full Text (HTML / PDF) |
July
review
Cancer-related inflammation
Alberto Mantovani, Paola Allavena, Antonio Sica & Frances Balkwill
Nature 454, 436–444
(24 July 2008); doi:10.1038/nature07205
| Summary | Full Text (HTML / PDF) |
perspective
Exploring the role of cancer stem cells in radioresistance
Michael Baumann, Mechthild Krause & Richard Hill
Nature Reviews Cancer 8, 545–554
(July 2008); doi:10.1038/nrc2419
| Summary | Full Text (HTML / PDF) |
article
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Rainer Fagerholm et al.
Nature Genetics 40, 844–853
doi:10.1038/ng.155
| Summary | Full Text (HTML / PDF) |
article
An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Ofra Benny et al.
Nature Biotechnology 26, 799–807
(July 2008); doi:10.1038/nbt1415
| Summary | Full Text (HTML / PDF) |
news and views
Hitting the mother lode of tumor angiogenesis
Daylon James, Sina Rabbany & Shahin Rafii
Nature Biotechnology 26, 769–770
(July 2008); doi:10.1038/nbt0708-769
| Full Text (HTML / PDF) |
review
Molecular imaging in drug development
Jürgen K. Willmann, Nicholas van Bruggen, Ludger M. Dinkelborg & Sanjiv S. Gambhir
Nature Reviews Drug Discovery 7, 591–607
(July 2008); doi:10.1038/nrd2290
| Summary | Full Text (HTML / PDF) |
article
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
Irene García-Higuera et al.
Nature Cell Biology 10, 802–811
(July 2008); doi:10.1038/ncb1742
| Summary | Full Text (HTML / PDF) |
news and views
Cdh1: a master G0/G1 regulator
Jeffrey R. Skaar & Michele Pagano
Nature Cell Biology 10, 755–757
(July 2008); doi:10.1038/ncb0708-755
| Full Text (HTML / PDF) |
perspective
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
David R. Croucher, Darren N. Saunders, Sergei Lobov & Marie Ranson
Nature Reviews Cancer 8, 535–545
(July 2008); doi:10.1038/nrc2400
| Summary | Full Text (HTML / PDF) |
letter
IRF4 addiction in multiple myeloma
Arthur L. Shaffer et al.
Nature 454, 226–231
(10 July 2008); doi:10.1038/nature07064
| Summary | Full Text (HTML / PDF) |
review
Ras oncogenes: split personalities
Antoine E. Karnoub & Robert A. Weinberg
Nature Reviews Molecular Cell Biology 9, 517–531
(July 2008); doi:10.1038/nrm2438
| Summary | Full Text (HTML / PDF) |
review
Living on a break: cellular senescence as a DNA-damage response
Fabrizio d'Adda di Fagagna
Nature Reviews Cancer 8, 512–522
(July 2008); doi:10.1038/nrc2440
| Summary | Full Text (HTML / PDF) |
review
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Roberto Cattaneo, Tanner Miest, Elena V. Shashkova & Michael A. Barry
Nature Reviews Microbiology 6, 529–540
(July 2008); doi:10.1038/nrmicro1927
| Summary | Full Text (HTML / PDF) |
review
MYB function in normal and cancer cells
Robert G. Ramsay & Thomas J. Gonda
Nature Reviews Cancer 8, 523–534
(July 2008); doi:10.1038/nrc2439
| Summary | Full Text (HTML / PDF) |
June
letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
| Summary | Full Text (HTML / PDF) |
article
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
Alessia Montagnoli et al.
Nature Chemical Biology 4, 357–365
(June 2008); doi:10.1038/nchembio.90
| Summary | Full Text (HTML / PDF) |
news and views
Stopping replication, at the beginning
Peter K Jackson
Nature Chemical Biology 4, 331–332
(June 2008); doi:10.1038/nchembio0608-331
| Full Text (HTML / PDF) |
article
PML targeting eradicates quiescent leukaemia-initiating cells
Keisuke Ito et al.
Nature 453, 1072–1078
(19 June 2008); doi:10.1038/nature07016
| Summary | Full Text (HTML / PDF) |
letter
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
Helene R. McMurray et al.
Nature 453, 1112–1116
(19 June 2008); doi:10.1038/nature06973
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Deconstructing oncogenesis
Ji Luo & Stephen J. Elledge
Nature 453, 995–996
(19 June 2008); doi:10.1038/453995a
| Full Text (HTML / PDF) |
article
The type I TGF-β receptor is covalently modified and regulated by sumoylation
Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst & Rik Derynck
Nature Cell Biology 10, 654–664
(June 2008); doi:10.1038/ncb1728
| Summary | Full Text (HTML / PDF) |
news and views
SUMO amplifies TGF-β signalling
Kohei Miyazono, Yuto Kamiya & Keiji Miyazawa
Nature Cell Biology 10, 635–637
(June 2008); doi:10.1038/ncb0608-635
| Full Text (HTML / PDF) |
review
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao & Benjamin Moeller
Nature Reviews Cancer 8, 425–437
(June 2008); doi:10.1038/nrc2397
| Summary | Full Text (HTML / PDF) |
perspective
The Mouse Tumor Biology database
Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult & Janan T. Eppig
Nature Reviews Cancer 8, 459–465
(June 2008); doi:10.1038/nrc2390
| Summary | Full Text (HTML / PDF) |
review
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Paolo M. Comoglio, Silvia Giordano & Livio Trusolino
Nature Reviews Drug Discovery 7, 504–516
(June 2008); doi:10.1038/nrd2530
| Summary | Full Text (HTML / PDF) |
review
Inhibitory B7-family molecules in the tumour microenvironment
Weiping Zou & Lieping Chen
Nature Reviews Immunology 8, 467–477
(June 2008); doi:10.1038/nri2326
| Summary | Full Text (HTML / PDF) |
review
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
David Frescas & Michele Pagano
Nature Reviews Cancer 8, 438–449
(June 2008); doi:10.1038/nrc2396
| Summary | Full Text (HTML / PDF) |
May
letter
p53 regulates glucose metabolism through an IKK–NF-κB pathway and inhibits cell transformation
Keiko Kawauchi, Keigo Araki, Kei Tobiume & Nobuyuki Tanaka
Nature Cell Biology 10, 611–618
(May 2008); doi:10.1038/ncb1724
| Summary | Full Text (HTML / PDF) |
review
Molecular pathogenesis of T-cell leukaemia and lymphoma
Iannis Aifantis, Elizabeth Raetz & Silvia Buonamici
Nature Reviews Immunology 8, 380–390
(May 2008); doi:10.1038/nri2304
| Summary | Full Text (HTML / PDF) |
perspective
Wnt signalling and its impact on development and cancer
Alexandra Klaus & Walter Birchmeier
Nature Reviews Cancer 8, 387–398
(May 2008); doi:10.1038/nrc2389
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letter
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Philip A. Gregory et al.
Nature Cell Biology 10, 593–601
(May 2008); doi:10.1038/ncb1722
| Summary | Full Text (HTML / PDF) |
news and views
MicroRNAs — keeping cells in formation
Eric A. Miska
Nature Cell Biology 10, 501–502
(May 2008); doi:10.1038/ncb0508-501
| Full Text (HTML / PDF) |
review
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Klaus Pantel, Ruud H. Brakenhoff & Burkhard Brandt
Nature Reviews Cancer 8, 329–340
(May 2008); doi:10.1038/nrc2375
| Summary | Full Text (HTML / PDF) |
letter
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Kevin M Haigis et al.
Nature Genetics 40, 600–608
(May 2008); doi:10.1038/ng.115
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letter
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah et al.
Nature 453, 410–414
(15 May 2008); doi:10.1038/nature06868
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article
Stromal gene expression predicts clinical outcome in breast cancer
Greg Finak et al.
Nature Medicine 14, 518–527
(May 2008); doi:10.1038/nm1764
| Summary | Full Text (HTML / PDF) |
review
Getting to the stem of chronic myeloid leukaemia
Michael Savona & Moshe Talpaz
Nature Reviews Cancer 8, 341–350
(May 2008); doi:10.1038/nrc2368
| Summary | Full Text (HTML / PDF) |
article
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Michael H. Tatham et al.
Nature Cell Biology 10, 538–546
(May 2008); doi:10.1038/ncb1716
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article
Arsenic degrades PML or PML-RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway
Valérie Lallemand-Breitenbach et al.
Nature Cell Biology 10, 547–555
(May 2008); doi:10.1038/ncb1717
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news and views
Marked for death
Kevin Petrie & Arthur Zelent
Nature Cell Biology 10, 507–509
(May 2008); doi:10.1038/ncb0508-507
| Full Text (HTML / PDF) |
review
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
H. Llewelyn Roderick & Simon J. Cook
Nature Reviews Cancer 8, 361–375
(May 2008); doi:10.1038/nrc2374
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letter
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
Wen Qiu et al.
Nature Genetics 40, 650–655
(May 2008); doi:10.1038/ng.117
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news and views
Coevolution in the tumor microenvironment
Robert A Weinberg
Nature Genetics 40, 494–495
(May 2008); doi:10.1038/ng0508-494
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letter
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
Nature 453, 110–114
(1 May 2008); doi:10.1038/nature06866
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letter
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Khalid Al-Nedawi et al.
Nature Cell Biology 10, 619–624
(May 2008); doi:10.1038/ncb1725
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perspective
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
John M. Pawelek & Ashok K. Chakraborty
Nature Reviews Cancer 8, 377–386
(May 2008); doi:10.1038/nrc2371
| Summary | Full Text (HTML / PDF) |
analysis
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
Ittai Ben-Porath et al.
Nature Genetics 40, 499–507
(May 2008); doi:10.1038/ng.127
| Summary | Full Text (HTML / PDF) |
April
review
GATA1-related leukaemias
Ritsuko Shimizu, James Douglas Engel & Masayuki Yamamoto
Nature Reviews Cancer 8, 279–287
(April 2008); doi:10.1038/nrc2348
| Summary | Full Text (HTML / PDF) |
article
MicroRNAs accurately identify cancer tissue origin
Nitzan Rosenfeld et al.
Nature Biotechnology 26, 462–469
(April 2008); doi:10.1038/nbt1392
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news and views
Cancer biomarker profiling with microRNAs
Stefanie S Jeffrey
Nature Biotechnology 26, 400–401
(April 2008); doi:10.1038/nbt0408-400
| Summary | Full Text (HTML / PDF) |
review
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Isabel M. Chu, Ludger Hengst & Joyce M. Slingerland
Nature Reviews Cancer 8, 253–267
(April 2008); doi:10.1038/nrc2347
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article
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Pekka Katajisto et al.
Nature Genetics 40, 455–459
(April 2008); doi:10.1038/ng.98
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perspective
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Rakesh K. Jain
Nature Reviews Cancer 8, 309–316
(April 2008); doi:10.1038/nrc2346
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letter
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
Nature 452, 646–649
(3 April 2008); doi:10.1038/nature06778
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letter
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
Ilaria Malanchi et al.
Nature 452, 650–653
(3 April 2008); doi:10.1038/nature06835
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review
The cancer biomarker problem
Charles L. Sawyers
Nature 452, 548–552
(3 April 2008); doi:10.1038/nature06913
| Summary | Full Text (HTML / PDF) |
review
Translating insights from the cancer genome into clinical practice
Lynda Chin & Joe W. Gray
Nature 452, 553–552
(3 April 2008); doi:10.1038/nature06914
| Summary | Full Text (HTML / PDF) |
review
Enabling personalized cancer medicine through analysis of gene-expression patterns
Laura J. van't Veer & René Bernards
Nature 452, 564–570
(3 April 2008); doi:10.1038/nature06915
| Summary | Full Text (HTML / PDF) |
review
Mining the plasma proteome for cancer biomarkers
Samir M. Hanash, Sharon J. Pitteri & Vitor M. Faca
Nature 452, 571–579
(3 April 2008); doi:10.1038/nature06916
| Summary | Full Text (HTML / PDF) |
review
Imaging in the era of molecular oncology
Ralph Weissleder & Mikael J. Pittet
Nature 452, 580–589
(3 April 2008); doi:10.1038/nature06917
| Summary | Full Text (HTML / PDF) |
March
review
Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability
Robert G. Bristow & Richard P. Hill
Nature Reviews Cancer 8, 180–192
(March 2008); doi:10.1038/nrc2344
| Summary | Full Text (HTML / PDF) |
review
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
Akeila Bellahcène, Vincent Castronovo, Kalu U. E. Ogbureke, Larry W. Fisher & Neal S. Fedarko
Nature Reviews Cancer 8, 212–226
(March 2008); doi:10.1038/nrc2345
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review
Interleukin 21: combination strategies for cancer therapy
Kresten Skak, Michael Kragh, Diana Hausman, Mark J. Smyth & Pallavur V. Sivakumar
Nature Reviews Drug Discovery 7, 231–240
(March 2008); doi:10.1038/nrd2482
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article
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara & Lewis C. Cantley
Nature 452, 181–186
(13 March 2008); doi:10.1038/nature06667
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letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230–233
(13 March 2008); doi:10.1038/nature06734
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article
SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
Hye-Jung Han, Jose Russo, Yoshinori Kohwi & Terumi Kohwi-Shigematsu
Nature 452, 187–193
(13 March 2008); doi:10.1038/nature06781
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article
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang et al.
Nature Cell Biology 10, 295–305
(March 2008); doi:10.1038/ncb1691
| Summary | Full Text (HTML / PDF) |
news and views
A hypoxic twist in metastasis
Héctor Peinado & Amparo Cano
Nature Cell Biology 10, 253–254
(March 2008); doi:10.1038/ncb0308-253
| Full Text (HTML / PDF) |
review
DNA repair pathways as targets for cancer therapy
Thomas Helleday, Eva Petermann, Cecilia Lundin, Ben Hodgson & Ricky A. Sharma
Nature Reviews Cancer 8, 193–204
(March 2008); doi:10.1038/nrc2342
| Summary | Full Text (HTML / PDF) |
perspective
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
Fiona M. Watt, Michaela Frye & Salvador Aznar Benitah
Nature Reviews Cancer 8, 234–242
(March 2008); doi:10.1038/nrc2328
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brief communication
Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene
Aytekin Akyol, Takao Hinoi, Ying Feng, Guido T Bommer, Thomas M Glaser & Eric R Fearon
Nature Methods 5, 231–233
(March 2008); doi:10.1038/nmeth.1182
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news and views
Harnessing mismatch repair to model sporadic cancers
Richard Fishel & Joanna Groden
Nature Methods 5, 225–226
(March 2008); doi:10.1038/nmeth0308-225
| Summary | Full Text (HTML / PDF) |
February
letter
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
Nature 451, 1111–1115
(28 February 2008); doi:10.1038/nature06548
| Summary | Full Text (HTML / PDF) |
letter
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai et al.
Nature 451, 1116–1120
(28 February 2008); doi:10.1038/nature06633
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news and views
Cancer: Crossing over to drug resistance
David M. Livingston & Daniel P. Silver
Nature 451, 1066–1067
(28 February 2008); doi:10.1038/4511066a
| Full Text (HTML / PDF) |
article
TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
Jiong Li & Cun-Yu Wang
Nature Cell Biology 10, 160–169
(February 2008); doi:10.1038/ncb1684
| Summary | Full Text (HTML / PDF) |
perspective
Is cell competition relevant to cancer?
Eduardo Moreno
Nature Reviews Cancer 8, 141–147
(February 2008); doi:10.1038/nrc2252
| Summary | Full Text (HTML / PDF) |
brief communication
A secreted luciferase for ex vivo monitoring of in vivo processes
Thomas Wurdinger et al.
Nature Methods 5, 171–173
(February 2008); doi:10.1038/nmeth.1177
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review
Ral GTPases and cancer: linchpin support of the tumorigenic platform
Brian O. Bodemann & Michael A. White
Nature Reviews Cancer 8, 133–140
(February 2008); doi:10.1038/nrc2296
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article
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
Nature Cell Biology 10, 138–148
(February 2008); doi:10.1038/ncb1676
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news and views
ERK and MDM2 prey on FOXO3a
Wensheng Yang, Nathan G. Dolloff & Wafik S. El-Deiry
Nature Cell Biology 10, 125–126
(February 2008); doi:10.1038/ncb0208-125
| Summary | Full Text (HTML / PDF) |
letter
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Qihong Huang et al.
Nature Cell Biology 10, 202–210
(February 2008); doi:10.1038/ncb1681
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review
New approaches for imaging tumour responses to treatment
Kevin Brindle
Nature Reviews Cancer 8, 94–107
(February 2008); doi:10.1038/nrc2289
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article
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
Sophie Pinner & Erik Sahai
Nature Cell Biology 10, 127–137
(February 2008); doi:10.1038/ncb1675
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article
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
Jessica Strid et al.
Nature Immunology 9, 146–154
(February 2008); doi:10.1038/ni1556
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news and views
Stress gets under your skin
Daniel M Andrews & Mark J Smyth
Nature Immunology 9, 119–120
(February 2008); doi:10.1038/ni0208-119
| Full Text (HTML / PDF) |
review
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
Anthony G. Letai
Nature Reviews Cancer 8, 121–132
(February 2008); doi:10.1038/nrc2297
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review
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
Markus Welcker & Bruce E. Clurman
Nature Reviews Cancer 8, 83–93
(February 2008); doi:10.1038/nrc2290
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brief communication
Site selectivity of platinum anticancer therapeutics
Bin Wu, Peter Dröge & Curt A Davey
Nature Chemical Biology 4, 110–112
(February 2008); doi:10.1038/nchembio.2007.58
| Summary | Full Text (HTML / PDF) |
January
review
The anaplastic lymphoma kinase in the pathogenesis of cancer
Roberto Chiarle, Claudia Voena, Chiara Ambrogio, Roberto Piva & Giorgio Inghirami
Nature Reviews Cancer 8, 11–23
(January 2008); doi:10.1038/nrc2291
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article
Widespread microRNA repression by Myc contributes to tumorigenesis
Tsung-Cheng Chang et al.
Nature Genetics 40, 43–50
(January 2008); doi:10.1038/ng.2007.30
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article
Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo
Erik Henke et al.
Nature Biotechnology 26, 91–100
(January 2008); doi:10.1038/nbt1366
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Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345–349
(17 January 2008); doi:10.1038/nature06489
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perspective
The interplay between MYC and HIF in cancer
Chi V. Dang, Jung-whan Kim, Ping Gao & Jason Yustein
Nature Reviews Cancer 8, 51–56
(January 2008); doi:10.1038/nrc2274
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AID is required for germinal center-derived lymphomagenesis
Laura Pasqualucci et al.
Nature Genetics 40, 108–112
(January 2008); doi:10.1038/ng.2007.35
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perspective
The emerging landscape of breast cancer susceptibility
Michael R Stratton & Nazneen Rahman
Nature Genetics 40, 17–22
(January 2008); doi:10.1038/ng.2007.53
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article
Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F. Tavazoie et al.
Nature 451, 147–152
(10 January 2008); doi:10.1038/nature06487
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Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu et al.
Nature 451, 202–206
(10 January 2008); doi:10.1038/nature06468
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GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
Masaki Morishige et al.
Nature Cell Biology 10, 85–92
(January 2008); doi:10.1038/ncb1672
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news and views
Getting invasive with GEP100 and Arf6
Ferran Valderrama & Anne J. Ridley
Nature Cell Biology 10, 16–18
(January 2008); doi:10.1038/ncb0108-16
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article
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
Ronald J Buckanovich et al.
Nature Medicine 14, 28–36
(January 2008); doi:10.1038/nm1699
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news and views
Opening the gateway to tumors
Michael H Kershaw
Nature Medicine 14, 13–14
(January 2008); doi:10.1038/nm0108-13
| Summary | Full Text (HTML / PDF) |
letter
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
Lao H Saal et al.
Nature Genetics 40, 102–107
(January 2008); doi:10.1038/ng.2007.39
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news and views
BRCA1—sowing the seeds crooked in the furrow
William D Foulkes
Nature Genetics 40, 8–9
(January 2008); doi:10.1038/ng0108-8
| Full Text (HTML / PDF) |
letter
Trisomy represses ApcMin-mediated tumours in mouse models of Down's syndrome
Thomas E. Sussan, Annan Yang, Fu Li, Michael C. Ostrowski & Roger H. Reeves
Nature 451, 73–75
(3 January 2008); doi:10.1038/nature06446
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letter
NUMB controls p53 tumour suppressor activity
Ivan N. Colaluca et al.
Nature 451, 76–80
(3 January 2008); doi:10.1038/nature06412
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review
Immunological aspects of cancer chemotherapy
Laurence Zitvogel, Lionel Apetoh, François Ghiringhelli & Guido Kroemer
Nature Reviews Immunology 8, 59–73
(January 2008); doi:10.1038/nri2216
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perspective
Survivin, cancer networks and pathway-directed drug discovery
Dario C. Altieri
Nature Reviews Cancer 8, 61–70
(January 2008); doi:10.1038/nrc2293
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