Research library: Cancer
2009:
| December
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December
letter
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
Jianmin Zhang et al.
Nature Cell Biology 11, 1444–1450
(December 2009); doi:10.1038/ncb1993
| Summary | Full Text (HTML / PDF) |
review
Integrins: masters and slaves of endocytic transport
Patrick T. Caswell, Suryakiran Vadrevu & Jim C. Norman
Nature Reviews Molecular Cell Biology 10, 843–853
(December 2009); doi:10.1038/nrm2799
| Summary | Full Text (HTML / PDF) |
review
Mucins in cancer: function, prognosis and therapy
Donald W. Kufe
Nature Reviews Cancer 9, 874–885
(December 2009); doi:10.1038/nrc2761
| Summary | Full Text (HTML / PDF) |
article
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
Nature 462, 739–744
(10 December 2009); doi:10.1038/nature08617
| Full Text (HTML / PDF) |
letter
Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region
Monica Gostissa et al.
Nature 462, 803–807
(10 December 2009); doi:10.1038/nature08633
| Full Text (HTML / PDF) |
article
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
Leandro C Cerchietti et al.
Nature Medicine 15, 1369–1376
(December 2009); doi:10.1038/nm.2059
| Summary | Full Text (HTML / PDF) |
review
Metabolism and cancer: the circadian clock connection
Saurabh Sahar & Paolo Sassone-Corsi
Nature Reviews Cancer 9, 886–896
(December 2009); doi:10.1038/nrc2747
| Summary | Full Text (HTML / PDF) |
letter
TAp63 induces senescence and suppresses tumorigenesis in vivo
Xuecui Guo et al.
Nature Cell Biology 11, 1451–1457
(December 2009); doi:10.1038/ncb1988
| Summary | Full Text (HTML / PDF) |
review
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown, Sonia Lain, Chandra S. Verma, Alan R. Fersht & David P. Lane
Nature Reviews Cancer 9, 862–873
(December 2009); doi:10.1038/nrc2763
| Summary | Full Text (HTML / PDF) |
November
review
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu, Drew Pardoll & Richard Jove
Nature Reviews Cancer 9, 798–809
(November 2009); doi:10.1038/nrc2734
| Summary | Full Text (HTML / PDF) |
review
NFAT proteins: emerging roles in cancer progression
Maria Mancini & Alex Toker
Nature Reviews Cancer 9, 810–820
(November 2009); doi:10.1038/nrc2735
| Summary | Full Text (HTML / PDF) |
letter
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
Anne Goriely et al.
Nature Genetics 41, 1247–1252
(November 2009); doi:10.1038/ng.470
| Summary | Full Text (HTML / PDF) |
analysis
An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer
Xiao-Song Wang et al.
Nature Biotechnology 27, 1005–1011
(November 2009); doi:10.1038/nbt.1584
| Summary | Full Text (HTML / PDF) |
article
KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancer
Kiranmai Gumireddy et al.
Nature Cell Biology 11, 1297–1304
(2009) doi:10.1038/ncb1974
| Summary | Full Text (HTML / PDF) |
review
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Hui-Zi Chen, Shih-Yin Tsai & Gustavo Leone
Nature Reviews Cancer 9, 785–797
(November 2009); doi:10.1038/nrc2696
| Summary | Full Text (HTML / PDF) |
letter
Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia
Charles G Mullighan et al.
Nature Genetics 41, 1243–1246
(November 2009); doi:10.1038/ng.469
| Summary | Full Text (HTML / PDF) |
article
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering et al.
Nature 462, 182–188
(12 November 2009); doi:10.1038/nature08543
| Full Text (HTML / PDF) |
news and views
Chemical biology: A Notch above other inhibitors
Paramjit S. Arora & Aseem Z. Ansari
Nature 462, 171–173
(12 November 2009); doi:10.1038/462171a
| Full Text (HTML / PDF) |
article
Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility
Silvia Giampieri et al.
Nature Cell Biology 11, 1287–1296
(November 2009) doi:10.1038/ncb1973
| Summary | Full Text (HTML / PDF) |
news and views
TGF-bold β helps cells fly solo
Lauren A. Matise, Michael W. Pickup & Harold L. Moses
Nature Cell Biology 11, 1281–1284
(November 2009) doi:10.1038/ncb1109-1281
| Summary | Full Text (HTML / PDF) |
review
p53 — a Jack of all trades but master of none
Melissa R. Junttila & Gerard I. Evan
Nature Reviews Cancer 9, 821–829
(November 2009); doi:10.1038/nrc2728
| Summary | Full Text (HTML / PDF) |
perspective
20 years studying p53 functions in genetically engineered mice
Lawrence A. Donehower & Guillermina Lozano
Nature Reviews Cancer 9, 831–841
(November 2009); doi:10.1038/nrc2731
| Summary | Full Text (HTML / PDF) |
article
The kinase TNIK is an essential activator of Wnt target genes
Tokameh Mahmoudi et al.
The EMBO Journal 28, 3329–3340
(November 2009); doi:10.1038/emboj.2009.285
| Summary | Full Text (HTML / PDF) |
letter
Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
Etienne Meylan et al.
Nature 462, 104–107
(05 November 2009); doi:10.1038/nature08462
| Full Text (HTML / PDF) |
letter
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie et al.
Nature 462, 108–112
(05 November 2009); doi:10.1038/nature08460
| Full Text (HTML / PDF) |
news and views
Cancer: A tumour gene's fatal flaws
Julian Downward
Nature 462, 44–45
(05 November 2009); doi:10.1038/462044a
| Full Text (HTML / PDF) |
review
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Adrian P. Bracken & Kristian Helin
Nature Reviews Cancer 9, 773–784
(November 2009); doi:10.1038/nrc2736
| Summary | Full Text (HTML / PDF) |
letter
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Adam J Bass et al.
Nature Genetics 41, 1238–1242
(November 2009); doi:10.1038/ng.465
| Summary | Full Text (HTML / PDF) |
October
article
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
François Ghiringhelli et al.
Nature Medicine 15, 1170–1178
(October 2009); doi:10.1038/nm.2028
| Summary | Full Text (HTML / PDF) |
review
When mutants gain new powers: news from the mutant p53 field
Ran Brosh & Varda Rotter
Nature Reviews Cancer 9, 701–713
(October 2009); doi:10.1038/nrc2693
| Summary | Full Text (HTML / PDF) |
review
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
Bin-Bing S. Zhou et al.
Nature Reviews Drug Discovery 8, 806–823
(October 2009); doi:10.1038/nrd2137
| Summary | Full Text (HTML / PDF) |
article
Pten in stromal fibroblasts suppresses mammary epithelial tumours
Anthony J. Trimboli et al.
Nature 461, 1084–1091
(22 October 2009); doi:10.1038/nature08486
| Full Text (HTML / PDF) |
article
An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression
Jay S Desgrosellier et al.
Nature Medicine 15, 1163–1169
(October 2009); doi:10.1038/nm.2009
| Summary | Full Text (HTML / PDF) |
article
Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death
Stefania Gonfloni et al.
Nature Medicine 15, 1179–1185
(October 2009); doi:10.1038/nm.2033
| Summary | Full Text (HTML / PDF) |
news and views
Preserving fertility during cancer treatment
Teresa K Woodruff
Nature Medicine 15, 1124–1125
(October 2009); doi:10.1038/nm1009-1124
| Full Text (HTML / PDF) |
review
Tumour suppression by p53: a role for the DNA damage response?
David W. Meek
Nature Reviews Cancer 9, 714–723
(October 2009); doi:10.1038/nrc2716
| Summary | Full Text (HTML / PDF) |
letter
In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
Corbin E Meacham, Emily E Ho, Esther Dubrovsky, Frank B Gertler & Michael T Hemann
Nature Genetics 41, 1133–1137
(October 2009); doi:10.1038/ng.451
| Summary | Full Text (HTML / PDF) |
review
Causes and consequences of microRNA dysregulation in cancer
Carlo M. Croce
Nature Reviews Genetics 10, 704–714
(October 2009); doi:10.1038/nrg2634
| Summary | Full Text (HTML / PDF) |
article
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
Marcin Kortylewski et al.
Nature Biotechnology 27, 925–932
(October 2009); doi:10.1038/nbt.1564
| Summary | Full Text (HTML / PDF) |
news and views
siRNA delivery not Toll-free
Michael P Gantier & Bryan R G Williams
Nature Biotechnology 27, 911–912
(October 2009); doi:10.1038/nbt1009-911
| Full Text (HTML / PDF) |
article
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
Giulia Fontemaggi et al.
Nature Structural & Molecular Biology 16, 1086–1093
(October 2009); doi:10.1038/nsmb.1669
| Summary | Full Text (HTML / PDF) |
letter
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Mark A. Dawson et al.
Nature 461, 819–822
(08 October 2009); doi:10.1038/nature08448
| Full Text (HTML / PDF) |
article
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling
Anne-Marie Martinez et al.
Nature Genetics 41, 1076–1082
(October 2009); doi:10.1038/ng.414
| Summary | Full Text (HTML / PDF) |
letter
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Todd D Prickett et al.
Nature Genetics 41, 1127–1132
(October 2009); doi:10.1038/ng.438
| Summary | Full Text (HTML / PDF) |
September
article
A luminal epithelial stem cell that is a cell of origin for prostate cancer
Xi Wang et al.
Nature 461, 495–500
(24 September 2009); doi:10.1038/nature08361
| Full Text (HTML / PDF) |
letter
p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Kaori Fujita et al.
Nature Cell Biology 11, 1135–1142
(September 2009); doi:10.1038/ncb1928
| Summary | Full Text (HTML / PDF) |
review
Biological determinants of endocrine resistance in breast cancer
Elizabeth A. Musgrove & Robert L. Sutherland
Nature Reviews Cancer 9, 631–643
(September 2009); doi:10.1038/nrc2713
| Summary | Full Text (HTML / PDF) |
review
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Pasi A. Jänne, Nathanael Gray & Jeff Settleman
Nature Reviews Drug Discovery 8, 709–723
(September 2009); doi:10.1038/nrd2871
| Summary | Full Text (HTML / PDF) |
letter
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Jennifer O. Lauchle et al.
Nature 461, 411–414
(17 September 2009); doi:10.1038/nature08279
| Full Text (HTML / PDF) |
perspective
Environment-mediated drug resistance: a major contributor to minimal residual disease
Mark B. Meads, Robert A. Gatenby & William S. Dalton
Nature Reviews Cancer 9, 665–674
(September 2009); doi:10.1038/nrc2714
| Summary | Full Text (HTML / PDF) |
review
Protein methyltransferases as a target class for drug discovery
Robert A. Copeland, Michael E. Solomon & Victoria M. Richon
Nature Reviews Drug Discovery 8, 724–732
(September 2009); doi:10.1038/nrd2974
| Summary | Full Text (HTML / PDF) |
article
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
Justin P Dassie et al.
Nature Biotechnology 27, 839–846
(September 2009); doi:10.1038/nbt.1560
| Summary | Full Text (HTML / PDF) |
news and views
Silencing prostate cancer
Ivanka Toudjarska & Antonin de Fougerolles
Nature Biotechnology 27, 821–823
(September 2009); doi:10.1038/nbt0909-821
| Full Text (HTML / PDF) |
letter
Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
Sunny Y Wong et al.
Nature Medicine 15, 1055–1061
(September 2009); doi:10.1038/nm.2011
| Summary | Full Text (HTML / PDF) |
letter
Dual and opposing roles of primary cilia in medulloblastoma development
Young-Goo Han et al.
Nature Medicine 15, 1062–1065
(September 2009); doi:10.1038/nm.2020
| Summary | Full Text (HTML / PDF) |
news and views
Two sides to cilia in cancer
Rune Toftgård
Nature Medicine 15, 994–996
(September 2009); doi:10.1038/nm0909-994
| Full Text (HTML / PDF) |
perspective
Cancer stem cells: mirage or reality?
Piyush B Gupta, Christine L Chaffer & Robert A Weinberg
Nature Medicine 15, 1010–1012
(September 2009); doi:10.1038/nm0909-1010
| Summary | Full Text (HTML / PDF) |
review
Interdependence of hypoxic and innate immune responses
Victor Nizet & Randall S. Johnson
Nature Reviews Immunology 9, 609–617
(September 2009); doi:10.1038/nri2607
| Summary | Full Text (HTML / PDF) |
review
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
Jianming Xu, Ray-Chang Wu & Bert W. O'Malley
Nature Reviews Cancer 9, 615–630
(September 2009); doi:10.1038/nrc2695
| Summary | Full Text (HTML / PDF) |
perspective
Systems genetics analysis of cancer susceptibility: from mouse models to humans
David Quigley & Allan Balmain
Nature Reviews Genetics 10, 651–657
(September 2009); doi:10.1038/nrg2617
| Summary | Full Text (HTML / PDF) |
August
review
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Jeffrey A. Engelman
Nature Reviews Cancer 9, 550–562
(August 2009); doi:10.1038/nrc2664
| Summary | Full Text (HTML / PDF) |
technical report
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis
Manav Korpal et al.
Nature Medicine 15, 960–966
(August 2009); doi:10.1038/nm.1943
| Summary | Full Text (HTML / PDF) |
review
Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner & Ángel R. Nebreda
Nature Reviews Cancer 9, 537–549
(August 2009); doi:10.1038/nrc2694
| Summary | Full Text (HTML / PDF) |
perspective
Crosstalk of Notch with p53 and p63 in cancer growth control
G. Paolo Dotto
Nature Reviews Cancer 9, 587–595
(August 2009); doi:10.1038/nrc2675
| Summary | Full Text (HTML / PDF) |
article
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
Sari Tuupanen et al.
Nature Genetics 41, 885–890
(August 2009); doi:10.1038/ng.406
| Summary | Full Text (HTML / PDF) |
brief communication
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
Mark M Pomerantz et al.
Nature Genetics 41, 882–884
(August 2009); doi:10.1038/ng.403
| Summary | Full Text (HTML / PDF) |
news and views
Elucidating the role of 8q24 in colorectal cancer
Olivier Harismendy & Kelly A. Frazer
Nature Genetics 41, 868–869
(August 2009); doi:10.1038/ng0809-868
| Full Text (HTML / PDF) |
letter
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
Masashi Sanada et al.
Nature 460, 904–908
(13 August 2009); doi:10.1038/nature08240
| Full Text (HTML / PDF) |
news and views
Cancer: More than kin and less than kind
Kevin Shannon & Mignon Loh
Nature 460, 804–807
(13 August 2009); doi:10.1038/460804a
| Full Text (HTML / PDF) |
letter
A role for Lin28 in primordial germ-cell development and germ-cell malignancy
Jason A. West et al.
Nature 460, 909–913
(13 August 2009); doi:10.1038/nature08210
| Full Text (HTML / PDF) |
review
Oncogenic stress sensed by the immune system: role of natural killer cell receptors
David H. Raulet & Nadia Guerra
Nature Reviews Immunology 9, 568–580
(August 2009); doi:10.1038/nri2604
| Summary | Full Text (HTML / PDF) |
review
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford & Reuben J. Shaw
Nature Reviews Cancer 9, 563–575
(August 2009); doi:10.1038/nrc2676
| Summary | Full Text (HTML / PDF) |
review
CYP2D6 and tamoxifen: DNA matters in breast cancer
Janelle M. Hoskins, Lisa A. Carey & Howard L. McLeod
Nature Reviews Cancer 9, 576–586
(August 2009); doi:10.1038/nrc2683
| Summary | Full Text (HTML / PDF) |
review
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu, Hailing Cheng, Thomas M. Roberts & Jean J. Zhao
Nature Reviews Drug Discovery 8, 627–644
(August 2009); doi:10.1038/nrd2926
| Summary | Full Text (HTML / PDF) |
July
perspective
Apoptosis and cancer: the genesis of a research field
Thomas G. Cotter
Nature Reviews Cancer 9, 501–507
(July 2009); doi:10.1038/nrc2663
| Summary | Full Text (HTML / PDF) |
letter
Acquired mutations in TET2 are common in myelodysplastic syndromes
Saskia M C Langemeijer et al.
Nature Genetics 41, 838–842
(July 2009); doi:10.1038/ng.391
| Summary | Full Text (HTML / PDF) |
news and views
TET2 mutations in myelodysplasia and myeloid malignancies
Charles G Mullighan
Nature Genetics 41, 766–767
(July 2009); doi:10.1038/ng0709-766
| Full Text (HTML / PDF) |
review
Cell cycle kinases as therapeutic targets for cancer
Silvia Lapenna & Antonio Giordano
Nature Reviews Drug Discovery 8, 547–566
(July 2009); doi:10.1038/nrd2907
| Summary | Full Text (HTML / PDF) |
letter
Modulation of microRNA processing by p53
Hiroshi I. Suzuki et al.
Nature 460, 529–533
(23 July 2009); doi:10.1038/nature08199
| Full Text (HTML / PDF) |
news and views
Cancer: Three birds with one stone
Franck Toledo & Boris Bardot
Nature 460, 466–467
(23 July 2009); doi:10.1038/460466a
| Full Text (HTML / PDF) |
review
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
José Baselga & Sandra M. Swain
Nature Reviews Cancer 9, 463–475
(July 2009); doi:10.1038/nrc2656
| Summary | Full Text (HTML / PDF) |
letter
Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer
Deborah Silvera et al.
Nature Cell Biology 11, 903–908
(July 2009); doi:10.1038/ncb1900
| Summary | Full Text (HTML / PDF) |
perspective
Wildlife cancer: a conservation perspective
Denise McAloose & Alisa L. Newton
Nature Reviews Cancer 9, 517–526
(July 2009); doi:10.1038/nrc2665
| Summary | Full Text (HTML / PDF) |
article
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
Yaoyu Chen, Yiguo Hu, Haojian Zhang, Cong Peng & Shaoguang Li
Nature Genetics 41, 783–792
(July 2009); doi:10.1038/ng.389
| Summary | Full Text (HTML / PDF) |
article
Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug
Jennifer A MacDiarmid et al.
Nature Biotechnology 27, 643–651
(July 2009); doi:10.1038/nbt.1547
| Summary | Full Text (HTML / PDF) |
news and views
Minicells overcome tumor drug-resistance
Emmanouil D Karagiannis & Daniel G Anderson
Nature Biotechnology 27, 620–621
(July 2009); doi:10.1038/nbt0709-620
| Full Text (HTML / PDF) |
review
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl & Darren Gilmour
Nature Reviews Molecular Cell Biology 10, 445–457
(July 2009); doi:10.1038/nrm2720
| Summary | Full Text (HTML / PDF) |
article
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
Hayriye V Erkizan et al.
Nature Medicine 15, 750–756
(July 2009); doi:10.1038/nm.1983
| Summary | Full Text (HTML / PDF) |
letter
Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain
Matthias Schweizerhof et al.
Nature Medicine 15, 802–807
(July 2009); doi:10.1038/nm.1976
| Summary | Full Text (HTML / PDF) |
review
Genetic prognostic and predictive markers in colorectal cancer
Axel Walther et al.
Nature Reviews Cancer 9, 489–499
(July 2009); doi:10.1038/nrc2645
| Summary | Full Text (HTML / PDF) |
letter
Lin28 promotes transformation and is associated with advanced human malignancies
Srinivas R Viswanathan et al.
Nature Genetics 41, 843–848
(July 2009); doi:10.1038/ng.392
| Summary | Full Text (HTML / PDF) |
news and views
Tumors line up for a letdown
Joshua T Mendell
Nature Genetics 41, 768–769
(July 2009); doi:10.1038/ng0709-768
| Full Text (HTML / PDF) |
review
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham, Jerome Alexandre & Peng Huang
Nature Reviews Drug Discovery 8, 579–591
(July 2009); doi:10.1038/nrd2803
| Summary | Full Text (HTML / PDF) |
review
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Andrew J. Holland & Don W. Cleveland
Nature Reviews Molecular Cell Biology 10, 478–487
(July 2009); doi:10.1038/nrm2718
| Summary | Full Text (HTML / PDF) |
June
article
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
Kenneth L. Scott et al.
Nature 459, 1085–1090
(25 June 2009); doi:10.1038/nature08109
| Full Text (HTML / PDF) |
article
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
Shu-Ping Wang et al.
Nature Cell Biology 11, 694–704
(June 2009); doi:10.1038/ncb1875
| Summary | Full Text (HTML / PDF) |
letter
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Silvia Buonamici et al.
Nature 459, 1000–1004
(18 June 2009); doi:10.1038/nature08020
| Full Text (HTML / PDF) |
letter
Genes that mediate breast cancer metastasis to the brain
Paula D. Bos et al.
Nature 459, 1005–1009
(18 June 2009); doi:10.1038/nature08021
| Full Text (HTML / PDF) |
review
p21 in cancer: intricate networks and multiple activities
Tarek Abbas & Anindya Dutta
Nature Reviews Cancer 9, 400–414
(June 2009); doi:10.1038/nrc2657
| Summary | Full Text (HTML / PDF) |
progress
New insights into the aetiology of colorectal cancer from genome-wide association studies
Albert Tenesa & Malcolm G. Dunlop
Nature Reviews Genetics 10, 353–358
(June 2009); doi:10.1038/nrg2574
| Summary | Full Text (HTML / PDF) |
review
The biology of ovarian cancer: new opportunities for translation
Robert C. Bast, Bryan Hennessy & Gordon B. Mills
Nature Reviews Cancer 9, 415–428
(June 2009); doi:10.1038/nrc2644
| Summary | Full Text (HTML / PDF) |
letter
Frequent inactivation of A20 in B-cell lymphomas
Motohiro Kato et al.
Nature 459, 712–716
(04 June 2009); doi:10.1038/nature07969
| Full Text (HTML / PDF) |
letter
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Mara Compagno et al.
Nature 459, 717–721
(04 June 2009); doi:10.1038/nature07968
| Full Text (HTML / PDF) |
May
review
Radiation-induced bystander signalling in cancer therapy
Kevin M. Prise & Joe M. O'Sullivan
Nature Reviews Cancer 9, 351–360
(May 2009); doi:10.1038/nrc2603
| Summary | Full Text (HTML / PDF) |
letter
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Sabrina L. Spencer, Suzanne Gaudet, John G. Albeck, John M. Burke & Peter K. Sorger
Nature 459, 428–432
(21 May 2009); doi:10.1038/nature08012
| Full Text (HTML / PDF) |
news and views
Systems biology: When it is time to die
Philippe Bastiaens
Nature 459, 334–335
(21 May 2009); doi:10.1038/459334a
| Full Text (HTML / PDF) |
perspective
The ups and downs of p53: understanding protein dynamics in single cells
Eric Batchelor, Alexander Loewer & Galit Lahav
Nature Reviews Cancer 9, 371–377
(May 2009); doi:10.1038/nrc2604
| Summary | Full Text (HTML / PDF) |
article
BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort et al.
Nature Genetics 41, 544–552
(May 2009); doi:10.1038/ng.356
| Summary | Full Text (HTML / PDF) |
article
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot
Tim Eiseler et al.
Nature Cell Biology 11, 545–556
(May 2009); doi:10.1038/ncb1861
| Summary | Full Text (HTML / PDF) |
progress
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Mark S. Cragg, Claire Harris, Andreas Strasser & Clare L. Scott
Nature Reviews Cancer 9, 321–326
(May 2009); doi:10.1038/nrc2615
| Summary | Full Text (HTML / PDF) |
article
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
The FANTOM Consortium & Riken Omics Science Center
Nature Genetics 41, 553–562
(May 2009); doi:10.1038/ng.375
| Summary | Full Text (HTML / PDF) |
article
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin
Dominique T. Brandt et al.
Nature Cell Biology 11, 557–568
(May 2009); doi:10.1038/ncb1862
| Summary | Full Text (HTML / PDF) |
news and views
SCAI blocks MAL-evolent effects on cancer cell invasion
Rudy Juliano
Nature Cell Biology 11, 540–542
(May 2009); doi:10.1038/ncb0509-540
| Full Text (HTML / PDF) |
technical report
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens
Alice C Fan et al.
Nature Medicine 15, 566–571
(May 2009); doi:10.1038/nm.1903
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letter
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
Brett S Carver et al.
Nature Genetics 41, 619–624
(May 2009); doi:10.1038/ng.370
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brief communication
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
Jennifer C King et al.
Nature Genetics 41, 524–526
(May 2009); doi:10.1038/ng.371
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news and views
TMPRSS2-ERG and PTEN loss in prostate cancer
Jeremy A Squire
Nature Genetics 41, 509–510
(May 2009); doi:10.1038/ng0509-509
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perspective
Tumour necrosis factor and cancer
Frances Balkwill
Nature Reviews Cancer 9, 361–371
(May 2009); doi:10.1038/nrc2628
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April
review
Microenvironmental regulation of metastasis
Johanna A. Joyce & Jeffrey W. Pollard
Nature Reviews Cancer 9, 239–252
(April 2009); doi:10.1038/nrc2618
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article
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
Andrew R Reynolds et al.
Nature Medicine 15, 392–400
(April 2009); doi:10.1038/nm.1941
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review
Learning therapeutic lessons from metastasis suppressor proteins
Steven Christopher Smith & Dan Theodorescu
Nature Reviews Cancer 9, 253–264
(April 2009); doi:10.1038/nrc2594
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letter
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
Amy V Jones et al.
Nature Genetics 41, 446–449
(April 2009); doi:10.1038/ng.334
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letter
A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms
Damla Olcaydu et al.
Nature Genetics 41, 450–454
(April 2009); doi:10.1038/ng.341
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letter
A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms
Outi Kilpivaara et al.
Nature Genetics 41, 455–459
(April 2009); doi:10.1038/ng.342
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news and views
Somatic and germline genetics at the JAK2 locus
Peter J Campbell
Nature Methods 41, 385–386
(April 2009); doi:10.1038/ng0409-385
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article
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany & David M. Sabatini
Nature 458, 725–731
(09 April 2009); doi:10.1038/nature07782
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news and views
Cancer: When restriction is good
Anne Brunet
Nature 458, 713–714
(09 April 2009); doi:10.1038/458713a
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article
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
Nature 458, 732–736
(09 April 2009); doi:10.1038/nature07884
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news and views
Drug Discovery: Fresh target for cancer therapy
Raymond J. Deshaies
Nature 458, 709–710
(09 April 2009); doi:10.1038/458709a
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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
Nature 458, 762–765
(09 April 2009); doi:10.1038/nature07823
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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao et al.
Nature 458, 776–779
(09 April 2009); doi:10.1038/nature07737
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review
The cancer genome
Michael R. Stratton, Peter J. Campbell & P. Andrew Futreal
Nature 458, 719–724
(09 April 2009); doi:10.1038/nature07943
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perspective
MicroRNAs — the micro steering wheel of tumour metastases
Milena S. Nicoloso, Riccardo Spizzo, Masayoshi Shimizu, Simona Rossi & George A. Calin
Nature Reviews Cancer 9, 293–302
(April 2009); doi:10.1038/nrc2619
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review
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Kornelia Polyak & Robert A. Weinberg
Nature Reviews Cancer 9, 265–273
(April 2009); doi:10.1038/nrc2620
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article
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation
Jing-Ruey J Yeh et al.
Nature Chemical Biology 5, 236–243
(April 2009); doi:10.1038/nchembio.147
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March
letter
Genetic architecture of mouse skin inflammation and tumour susceptibility
David A. Quigley et al.
Nature 458, 505–508
(26 March 2009); doi:10.1038/nature07683
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letter
Regulation of endocytosis via the oxygen-sensing pathway
Yi Wang et al.
Nature Medicine 15, 319–324
(March 2009); doi:10.1038/nm.1922
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news and views
Oxygen sensor boosts growth factor signaling
Mien-Chie Hung, Gordon B Mills & Dihua Yu
Nature Medicine 15, 246–247
(March 2009); doi:10.1038/nm0309-246
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review
Beyond chemotherapy: targeted therapies in ovarian cancer
Timothy A. Yap, Craig P. Carden & Stan B. Kaye
Nature Reviews Cancer 9, 167–181
(March 2009); doi:10.1038/nrc2583
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letter
The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells
Barak Blum, Ori Bar-Nur, Tamar Golan-Lev & Nissim Benvenisty
Nature Biotechnology 27, 281–287
(March 2009); doi:10.1038/nbt.1527
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article
A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal
Federica Catalanotti et al.
Nature Structural & Molecular Biology 16, 294–303
(March 2009); doi:10.1038/nsmb.1564
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article
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
Souhila Medjkane, Cristina Perez-Sanchez, Cedric Gaggioli, Erik Sahai & Richard Treisman
Nature Cell Biology 11, 257–268
(March 2009); doi:10.1038/ncb1833
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letter
Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity
Arvind Shakya et al.
Nature Cell Biology 11, 320–327
(March 2009); doi:10.1038/ncb1840
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review
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres & Mariano Barbacid
Nature Reviews Cancer 9, 153–166
(March 2009); doi:10.1038/nrc2602
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research
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
Vincent W Keng et al.
Nature Biotechnology 27, 264–274
(March 2009); doi:10.1038/nbt.1526
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news and views
Jump-starting cancer gene discovery
Anthony Uren & Anton Berns
Nature Biotechnology 27, 251–252
(March 2009); doi:10.1038/nbt0309-251
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review
Molecular targets for cancer chemoprevention
William N. William, Jr, John V. Heymach, Edward S. Kim & Scott M. Lippman
Nature Reviews Drug Discovery 8, 213–225
(March 2009); doi:10.1038/nrd2663
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review
Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies
Jeff S. Isenberg, Gema Martin-Manso, Justin B. Maxhimer & David D. Roberts
Nature Reviews Cancer 9, 182–194
(March 2009); doi:10.1038/nrc2561
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letter
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Sonia A Melo et al.
Nature Genetics 41, 365–370
(March 2009); doi:10.1038/ng.317
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Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival
Nicolas Bidère et al.
Nature 458, 92–96
(March 2009); doi:10.1038/nature07613
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Transcriptome sequencing to detect gene fusions in cancer
Christopher A. Maher et al.
Nature 458, 97–101
(March 2009); doi:10.1038/nature07638
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The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways
Masashi Kajiro et al.
Nature Cell Biology 11, 312–319
(March 2009); doi:10.1038/ncb1839
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news and views
Breast cancer quality control
Cam Patterson & Sarah Ronnebaum
Nature Cell Biology 11, 239–241
(March 2009); doi:10.1038/ncb0309-239
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review
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
Hildegard M. Schuller
Nature Reviews Cancer 9, 195–205
(March 2009); doi:10.1038/nrc2590
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February
perspective
How does SIRT1 affect metabolism, senescence and cancer?
Christopher L. Brooks & Wei Gu
Nature Reviews Cancer 9, 123–128
(February 2009); doi:10.1038/nrc2562
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brief communication
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts
Jean Y Perentes et al.
Nature Methods 6, 143–145
(February 2009); doi:10.1038/nmeth.1295
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article
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7
Surabhi Dangi-Garimella et al.
The EMBO Journal 28, 347–358
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Nuclear signalling by tumour-associated antigen EpCAM
Dorothea Maetzel et al.
Nature Cell Biology 11, 162–171
(February 2009); doi:10.1038/ncb1824
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review
p53 polymorphisms: cancer implications
Catherine Whibley, Paul D. P. Pharoah & Monica Hollstein
Nature Reviews Cancer 9, 95–107
(February 2009); doi:10.1038/nrc2584
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The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
Alessandra Rustighi et al.
Nature Cell Biology 11, 133–142
(February 2009); doi:10.1038/ncb1822
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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
Rafael A Irizarry et al.
Nature Genetics 41, 178–186
(February 2009); doi:10.1038/ng.298
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Dynamic modularity in protein interaction networks predicts breast cancer outcome
Ian W Taylor et al.
Nature Biotechnology 27, 199–204
(February 2009); doi:10.1038/nbt.1522
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article
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen et al.
Nature Chemical Biology 5, 100–107
(February 2009); doi:10.1038/nchembio.137
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news and views
Novel Wnt antagonists target porcupine and Axin
Jing-Ruey J Yeh & Randall T Peterson
Nature Chemical Biology 5, 74–75
(February 2009); doi:10.1038/nchembio0209-74
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review
A tense situation: forcing tumour progression
Darci T. Butcher, Tamara Alliston & Valerie M. Weaver
Nature Reviews Cancer 9, 108–122
(February 2009); doi:10.1038/nrc2544
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article
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
Sarah A Scott et al.
Nature Chemical Biology 5, 108–117
(February 2009); doi:10.1038/nchembio.140
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January
perspective
Toll-like receptors and cancer
Seth Rakoff-Nahoum & Ruslan Medzhitov
Nature Reviews Cancer 9, 57–63
(January 2009); doi:10.1038/nrc2541
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review
Mechanotransduction gone awry
Diana E. Jaalouk & Jan Lammerding
Nature Reviews Molecular Cell Biology 10, 63–73
(January 2009); doi:10.1038/nrm2597
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article
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
Ulrike Stein et al.
Nature Medicine 15, 59–67
(January 2009); doi:10.1038/nm.1889
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review
Tetraspanins: push and pull in suppressing and promoting metastasis
Margot Zöller
Nature Reviews Cancer 9, 40–55
(January 2009); doi:10.1038/nrc2543
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Characterization of human embryonic stem cells with features of neoplastic progression
Tamra E Werbowetski-Ogilvie et al.
Nature Biotechnology 27, 91–97
(January 2009); doi:10.1038/nbt.1516
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perspective
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
Véronique Baud & Michael Karin
Nature Reviews Drug Discovery 8, 33–40
(January 2009); doi:10.1038/nrd2781
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article
High-resolution mapping of copy-number alterations with massively parallel sequencing
Derek Y Chiang et al.
Nature Methods 6, 99–103
(January 2009); doi:10.1038/nmeth.1276
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article
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J Real et al.
Nature Medicine 15, 50–58
(January 2009); doi:10.1038/nm.1900
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news and views
γ-secretase inhibitors: Notch so bad
Gerard C Grosveld
Nature Medicine 15, 20–21
(January 2009); doi:10.1038/nm0109-20
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review
The biology of Hodgkin's lymphoma
Ralf Küppers
Nature Reviews Cancer 9, 15–27
(January 2009); doi:10.1038/nrc2542
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letter
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
Jinyan Du et al.
Nature Biotechnology 27, 77–83
(January 2009); doi:10.1038/nbt.1513
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Cancer induction by restriction of oncogene expression to the stem cell compartment
María Pérez-Caro et al.
The EMBO Journal 28, 8–20
(January 2009); doi:10.1038/emboj.2008.253
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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
Nature 457, 200–204
(08 January 2009); doi:10.1038/nature07475
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Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Debashis Ghosh, Jennifer Griswold, Mary Erman & Walter Pangborn
Nature 457, 219–223
(08 January 2009); doi:10.1038/nature07614
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news and views
Structural biology: Anticancer drug target pictured
Michael R. Waterman
Nature 457, 159–160
(08 January 2009); doi:10.1038/457159a
| Full Text (HTML / PDF) |
review
Targeting cancer with small molecule kinase inhibitors
Jianming Zhang, Priscilla L. Yang & Nathanael S. Gray
Nature Reviews Cancer 9, 28–39
(January 2009); doi:10.1038/nrc2559
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