Research library: Cancer
2010:
| August
| July
| June
| May
| April
| March
| February
| January
Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009
August
article
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Hsiangling Teo et al.
Nature Cell Biology 12, 758–767
(August 2010); doi:10.1038/ncb2080
| Summary | Full Text (HTML / PDF) |
article
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites
Paula Martinez et al.
Nature Cell Biology 12, 768–780
(August 2010); doi:10.1038/ncb2081
| Summary | Full Text (HTML / PDF) |
news and views
Mammalian Rap1 widens its impact
Laure Crabbe & Jan Karlseder
Nature Cell Biology 12, 733–735
(August 2010); doi:10.1038/ncb2088
| Summary | Full Text (HTML / PDF) |
review
Prostate cancer as a model for tumour immunotherapy
Charles G. Drake
Nature Reviews Immunology 10, 580–593
(August 2010); doi:10.1038/nri2817
| Summary | Full Text (HTML / PDF) |
article
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
Michael G Kharas et al.
Nature Medicine 16, 903–908
(August 2010); doi:10.1038/nm.2187
| Summary | Full Text (HTML / PDF) |
review
Targeting the ANGPT–TIE2 pathway in malignancy
Hanhua Huang, Abhijit Bhat, Gary Woodnutt & Rodney Lappe
Nature Reviews Cancer 10, 575–585
(August 2010); doi:10.1038/nrc2894
| Summary | Full Text (HTML / PDF) |
letter
Regulation of myeloid leukaemia by the cell-fate determinant Musashi
Takahiro Ito et al.
Nature 466, 765–768
(05 August 2010); doi:10.1038/nature09171
| Full Text (HTML / PDF) |
letter
Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells
Jose L. Garcia-Perez et al.
Nature 466, 769–773
(05 August 2010); doi:10.1038/nature09209
| Full Text (HTML / PDF) |
article
Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
Daniel J Hodson et al.
Nature Immunology 11, 717–724
(August 2010); doi:10.1038/ni.1901
| Summary | Full Text (HTML / PDF) |
news and views
RNA-binding proteins come out of the shadows
Jelena Nedjic & Iannis Aifantis
Nature Immunology 11, 697–698
(August 2010); doi:10.1038/ni0810-697
| Full Text (HTML / PDF) |
review
The polarization of immune cells in the tumour environment by TGFß
Richard A. Flavell, Shomyseh Sanjabi, Stephen H. Wrzesinski & Paula Licona-Limón
Nature Reviews Immunology 10, 554–567
(August 2010); doi:10.1038/nri2808
| Summary | Full Text (HTML / PDF) |
article
Lipid accumulation and dendritic cell dysfunction in cancer
Donna L Herber et al.
Nature Medicine 16, 880–886
(August 2010); doi:10.1038/nm.2172
| Summary | Full Text (HTML / PDF) |
news and views
Targeting dendritic cell metabolism in cancer
Laurence Zitvogel & Guido Kroemer
Nature Medicine 16, 858–859
(August 2010); doi:10.1038/nm0810-858
| Full Text (HTML / PDF) |
review
Targeting the dynamic HSP90 complex in cancer
Jane Trepel, Mehdi Mollapour, Giuseppe Giaccone & Len Neckers
Nature Reviews Cancer 10, 537–549
(August 2010); doi:10.1038/nrc2887
| Summary | Full Text (HTML / PDF) |
review
IAPs: from caspase inhibitors to modulators of NF-?B, inflammation and cancer
Mads Gyrd-Hansen & Pascal Meier
Nature Reviews Cancer 10, 561–574
(August 2010); doi:10.1038/nrc2889
| Summary | Full Text (HTML / PDF) |
article
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
Michael C Haffner et al.
Nature Genetics 42, 668–675
(August 2010); doi:10.1038/ng.613
| Summary | Full Text (HTML / PDF) |
news and views
On the origin of prostate fusion oncogenes
Jiri Bartek, Petra Hamerlik & Jiri Lukas
Nature Genetics 42, 647–648
(August 2010); doi:10.1038/ng0810-647
| Full Text (HTML / PDF) |
letter
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Thomas Ernst et al.
Nature Genetics 42, 722–726
(August 2010); doi:10.1038/ng.621
| Summary | Full Text (HTML / PDF) |
July
letter
LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium
Jiusheng Yan & Richard W. Aldrich
Nature 466, 513–516
(22 July 2010); doi:10.1038/nature09162
| Full Text (HTML / PDF) |
letter
An autoimmune-mediated strategy for prophylactic breast cancer vaccination
Ritika Jaini et al.
Nature Medicine 16, 799–803
(July 2010); doi:10.1038/nm.2161
| Summary | Full Text (HTML / PDF) |
article
Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
Frédéric Chibon et al.
Nature Medicine 16, 781–787
(July 2010); doi:10.1038/nm.2174
| Summary | Full Text (HTML / PDF) |
letter
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
Nallasivam Palanisamy et al.
Nature Medicine 16, 781–787
(July 2010); doi:10.1038/nm.2166
| Summary | Full Text (HTML / PDF) |
news and views
RAF translocations expand cancer targets
Martin McMahon
Nature Medicine 16, 749–750
(July 2010); doi:10.1038/nm0710-749
| Summary | Full Text (HTML / PDF) |
review
Sphingosine 1-phosphate and cancer
Nigel J. Pyne & Susan Pyne
Nature Reviews Cancer 10, 489–503
(July 2010); doi:10.1038/nrc2875
| Summary | Full Text (HTML / PDF) |
letter
Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer
Clare Turnbull et al.
Nature Genetics 42, 604–607
(July 2010); doi:10.1038/ng.607
| Summary | Full Text (HTML / PDF) |
research
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
Mallika Singh et al.
Nature Biotechnology 28, 585–593
(June 2010); doi:10.1038/nbt.1640
| Summary | Full Text (HTML / PDF) |
news and views
Raising the bar for cancer therapy models
Giulio Francia & Robert S Kerbel
Nature Biotechnology 28, 561–562
(June 2010); doi:10.1038/nbt0610-561
| Full Text (HTML / PDF) |
perspective
Integrating molecular diagnostics into anticancer drug discovery
István Peták, Richárd Schwab, László Orfi, László Kopper & György Kéri
Nature Reviews Drug Discovery 9, 523–535
(July 2010); doi:10.1038/nrd3135
| Summary | Full Text (HTML / PDF) |
article
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Laura Poliseno et al.
Nature 465, 1033–1038
(24 June 2010); doi:10.1038/nature09144
| Full Text (HTML / PDF) |
news and views
Gene-expression forum: Decoy for microRNAs
Isidore Rigoutsos & Frank Furnari
Nature 465, 1016–1017
(24 June 2010); doi:10.1038/4651016a
| Full Text (HTML / PDF) |
article
Structural basis for the suppression of skin cancers by DNA polymerase η
Timothy D. Silverstein et al.
Nature 465, 1039–1043
(24 June 2010); doi:10.1038/nature09104
| Full Text (HTML / PDF) |
article
Structure and mechanism of human DNA polymerase η
Christian Biertümpfel et al.
Nature 465, 1044–1048
(24 June 2010); doi:10.1038/nature09196
| Full Text (HTML / PDF) |
news and views
DNA repair: How to accurately bypass damage
Suse Broyde & Dinshaw J. Patel
Nature 465, 1023–1024
(24 June 2010); doi:10.1038/4651023a
| Full Text (HTML / PDF) |
review
Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers
Ping Chi, C. David Allis & Gang Greg Wang
Nature Reviews Cancer 10, 457–469
(July 2010); doi:10.1038/nrc2876
| Summary | Full Text (HTML / PDF) |
letter
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
Jin-Xin Bei et al.
Nature Genetics 42, 599–603
(July 2010); doi:10.1038/ng.601
| Summary | Full Text (HTML / PDF) |
June
article
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
Ataman Sendoel, Ines Kohler, Christof Fellmann, Scott W. Lowe & Michael O. Hengartner
Nature 465, 577–583
(03 June 2010); doi:10.1038/nature09141
| Full Text (HTML / PDF) |
news and views
Apoptosis: Lack of oxygen aids cell survival
Jo Anne Powell-Coffman & Clark R. Coffman
Nature 465, 554–555
(03 June 2010); doi:10.1038/465554a
| Full Text (HTML / PDF) |
review
TGFβ signalling: a complex web in cancer progression
Hiroaki Ikushima & Kohei Miyazono
Nature Reviews Cancer 10, 415–424
(June 2010); doi:10.1038/nrc2853
| Summary | Full Text (HTML / PDF) |
letter
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
William Lee et al.
Nature 465, 473–477
(27 May 2010); doi:10.1038/nature09004
| Full Text (HTML / PDF) |
letter
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
Suphansa Sawamiphak et al.
Nature 465, 487–491
(27 May 2010); doi:10.1038/nature08995
| Full Text (HTML / PDF) |
letter
CD95 promotes tumour growth
Lina Chen et al.
Nature 465, 492–496
(27 May 2010); doi:10.1038/nature09075
| Full Text (HTML / PDF) |
news and views
Cancer: A wolf in wolf's clothing
Douglas R. Green
Nature 465, 433
(27 May 2010); doi:10.1038/465433a
| Full Text (HTML / PDF) |
review
Genetic variation in microRNA networks: the implications for cancer research
Bríd M. Ryan, Ana I. Robles & Curtis C. Harris
Nature Reviews Cancer 10, 389–402
(June 2010); doi:10.1038/nrc2867
| Summary | Full Text (HTML / PDF) |
letter
Genome-wide association study identifies five new breast cancer susceptibility loci
Clare Turnbull et al.
Nature Genetics 42, 504–507
(June 2010); doi:10.1038/ng.586
| Summary | Full Text (HTML / PDF) |
article
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
Johan H. van Es, Natalie de Geest, Maaike van de Born, Hans Clevers & Bassem A. Hassan
Nature Communications 1, 1–5
(May 2010); doi:10.1038/ncomms1017
| Summary | Full Text (HTML / PDF) |
May
letter
Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay
Fernando Pastor, Despina Kolonias, Paloma H. Giangrande & Eli Gilboa
Nature 465, 227–230
(13 May 2010); doi:10.1038/nature08999
| Full Text (HTML / PDF) |
letter
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Johanna C. Scheuermann et al.
Nature 465, 243–247
(13 May 2010); doi:10.1038/nature08966
| Full Text (HTML / PDF) |
article
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
Chia-Hsin Chan et al.
Nature Cell Biology 12, 457–467
(May 2010); doi:10.1038/ncb2047
| Summary | Full Text (HTML / PDF) |
article
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Louis Vermeulen et al.
Nature Cell Biology 12, 468–476
(May 2010); doi:10.1038/ncb2048
| Summary | Full Text (HTML / PDF) |
news and views
Cancer stem cells: nature versus nurture
Hasan Korkaya & Max S. Wicha
Nature Cell Biology 12, 419–421
(May 2010); doi:10.1038/ncb0510-419
| Full Text (HTML / PDF) |
letter
The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells
Ailine Stolz et al.
Nature Cell Biology 12, 492–499
(May 2010); doi:10.1038/ncb2051
| Summary | Full Text (HTML / PDF) |
news and views
A mitotic role for the DNA damage-responsive CHK2 kinase
Ko Sato, Tomohiko Ohta & Ashok R. Venkitaraman
Nature Cell Biology 12, 424–425
(May 2010); doi:10.1038/ncb0510-424
| Full Text (HTML / PDF) |
review
A20: from ubiquitin editing to tumour suppression
Sarah G. Hymowitz & Ingrid E. Wertz
Nature Reviews Cancer 10, 332–341
(May 2010); doi:10.1038/nrc2775
| Summary | Full Text (HTML / PDF) |
letter
Mutation of the RAD51C gene in a Fanconi anemia–like disorder
Fiona Vaz et al.
Nature Genetics 42, 406–409
(May 2010); doi:10.1038/ng.570
| Summary | Full Text (HTML / PDF) |
letter
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Alfons Meindl et al.
Nature Genetics 42, 410–414
(May 2010); doi:10.1038/ng.569
| Summary | Full Text (HTML / PDF) |
news and views
Fanconi anemia and breast cancer susceptibility meet again
Ephrat Levy-Lahad
Nature Genetics 42, 368–369
(May 2010); doi:10.1038/ng0510-368
| Full Text (HTML / PDF) |
letter
Subtle variations in Pten dose determine cancer susceptibility
Andrea Alimonti et al.
Nature Genetics 42, 454–458
(May 2010); doi:10.1038/ng.556
| Summary | Full Text (HTML / PDF) |
review
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera & Benoit Bilanges
Nature Reviews Molecular Cell Biology 11, 329–341
(May 2010); doi:10.1038/nrm2882
| Summary | Full Text (HTML / PDF) |
review
Phosphoinositide signalling in cancer: beyond PI3K and PTEN
Tom D. Bunney & Matilda Katan
Nature Reviews Cancer 10, 342–352
(May 2010); doi:10.1038/nrc2842
| Summary | Full Text (HTML / PDF) |
April
letter
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta et al.
Nature 464, 1071–1076
(15 April 2010); doi:10.1038/nature08975
| Full Text (HTML / PDF) |
article
BRD7 is a candidate tumour suppressor gene required for p53 function
Jarno Drost et al.
Nature Cell Biology 12, 380–389
(April 2010); doi:10.1038/ncb2038
| Summary | Full Text (HTML / PDF) |
review
Translational control in cancer
Deborah Silvera, Silvia C. Formenti & Robert J. Schneider
Nature Reviews Cancer 10, 254–266
(April 2010); doi:10.1038/nrc2824
| Summary | Full Text (HTML / PDF) |
review
The regulatory crosstalk between kinases and proteases in cancer
Carlos López-Otín & Tony Hunter
Nature Reviews Cancer 10, 278–292
(April 2010); doi:10.1038/nrc2823
| Summary | Full Text (HTML / PDF) |
perspective
PARP inhibition: PARP1 and beyond
Michèle Rouleau, Anand Patel, Michael J. Hendzel, Scott H. Kaufmann & Guy G. Poirier
Nature Reviews Cancer 10, 293–301
(April 2010); doi:10.1038/nrc2812
| Summary | Full Text (HTML / PDF) |
March
article
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Hui-Kuan Lin et al.
Nature 464, 374–379
(18 March 2010); doi:10.1038/nature08815
| Full Text (HTML / PDF) |
letter
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag, Kevan M. Shokat & Neal Rosen
Nature 464, 427–430
(18 March 2010); doi:10.1038/nature08902
| Full Text (HTML / PDF) |
letter
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Georgia Hatzivassiliou et al.
Nature 464, 431–435
(18 March 2010); doi:10.1038/nature08833
| Full Text (HTML / PDF) |
letter
TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
Arindam Chaudhury et al.
Nature Cell Biology 12, 286–293
(March 2010); doi:10.1038/ncb2029
| Summary | Full Text (HTML / PDF) |
review
Genomic instability — an evolving hallmark of cancer
Simona Negrini, Vassilis G. Gorgoulis & Thanos D. Halazonetis
Nature Reviews Molecular Cell Biology 11, 220–228
(March 2010); doi:10.1038/nrm2858
| Summary | Full Text (HTML / PDF) |
review
Eicosanoids and cancer
Dingzhi Wang & Raymond N. DuBois
Nature Reviews Cancer 10, 181–193
(March 2010); doi:10.1038/nrc2809
| Summary | Full Text (HTML / PDF) |
review
Microtubules and resistance to tubulin-binding agents
Maria Kavallaris
Nature Reviews Cancer 10, 194–204
(March 2010); doi:10.1038/nrc2803
| Summary | Full Text (HTML / PDF) |
review
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
Elena B. Pasquale
Nature Reviews Cancer 10, 165–180
(March 2010); doi:10.1038/nrc2806
| Summary | Full Text (HTML / PDF) |
February
article
Signatures of mutation and selection in the cancer genome
Graham R. Bignell et al.
Nature 463, 893–898
(18 February 2010); doi:10.1038/nature08768
| Full Text (HTML / PDF) |
article
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim et al.
Nature 463, 899–905
(18 February 2010); doi:10.1038/nature08822
| Full Text (HTML / PDF) |
review
BRCA1 and its toolbox for the maintenance of genome integrity
Michael S.Y. Huen, Shirley M.H. Sy & Junjie Chen
Nature Reviews Molecular Cell Biology 11, 138–148
(February 2010); doi:10.1038/nrm2831
| Summary | Full Text (HTML / PDF) |
letter
TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Kazuhito Naka et al.
Nature 463, 676–680
(04 February 2010); doi:10.1038/nature08734
| Full Text (HTML / PDF) |
letter
Interaction between RasV12 and scribbled clones induces tumour growth and invasion
Ming Wu, José Carlos Pastor-Pareja & Tian Xu
Nature 463, 545–548
(28 January 2010); doi:10.1038/nature08702
| Full Text (HTML / PDF) |
January
article
The transcriptional network for mesenchymal transformation of brain tumours
Maria Stella Carro et al.
Nature 463, 318–325
(21 January 2010); doi:10.1038/nature08712
| Full Text (HTML / PDF) |
letter
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David, Mo Chen, Marcela Assanah, Peter Canoll & James L. Manley
Nature 463, 364–368
(21 January 2010); doi:10.1038/nature08697
| Full Text (HTML / PDF) |
brief communication
In vivo selection of tumor-targeting RNA motifs
Jing Mi et al.
Nature Chemical Biology 6, 22–24
(January 2010); doi:10.1038/nchembio.277
| Summary | Full Text (HTML / PDF) |
review
From pathogenesis to treatment of chronic lymphocytic leukaemia
Thorsten Zenz, Daniel Mertens, Ralf Küppers, Hartmut Döhner & Stephan Stilgenbauer
Nature Reviews Cancer 10, 37–50
(January 2010); doi:10.1038/nrc2764
| Summary | Full Text (HTML / PDF) |
analysis
A census of amplified and overexpressed human cancer genes
Thomas Santarius, Janet Shipley, Daniel Brewer, Michael R. Stratton & Colin S. Cooper
Nature Reviews Cancer 10, 59–64
(January 2010); doi:10.1038/nrc2771
| Summary | Full Text (HTML / PDF) |
perspective
Emerging roles of ATF2 and the dynamic AP1 network in cancer
Pablo Lopez-Bergami, Eric Lau & Ze'ev Ronai
Nature Reviews Cancer 10, 65–76
(January 2010); doi:10.1038/nrc2681
| Summary | Full Text (HTML / PDF) |
letter
Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies
Selvaraju Veeriah et al.
Nature Genetics 42, 77–82
(January 2010); doi:10.1038/ng.491
| Summary | Full Text (HTML / PDF) |
letter
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice
Hongbo Wang et al.
Nature Genetics 42, 83–88
(January 2010); doi:10.1038/ng.498
| Summary | Full Text (HTML / PDF) |
review
Integrins in cancer: biological implications and therapeutic opportunities
Jay S. Desgrosellier & David A. Cheresh
Nature Reviews Cancer 10, 9–22
(January 2010); doi:10.1038/nrc2748
| Summary | Full Text (HTML / PDF) |
review
IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
Julia Bollrath & Florian R. Greten
EMBO reports 10, 1314–1319
(December 2009); doi:10.1038/embor.2009.243
| Summary | Full Text (HTML / PDF) |
article
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome
Jillian L Barlow et al.
Nature Medicine 16, 59–66
(January 2010); doi:10.1038/nm.2063
| Summary | Full Text (HTML / PDF) |
article
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Daniel T Starczynowski et al.
Nature Medicine 16, 49–58
(January 2010); doi:10.1038/nm.2054
| Summary | Full Text (HTML / PDF) |
news and views
Myelodysplasia: battle in the bone marrow
Yan Liu, Takashi Asai & Stephen D Nimer
Nature Medicine 16, 30–32
(January 2010); doi:10.1038/nm0110-30
| Full Text (HTML / PDF) |
letter
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
R. Eric Davis et al.
Nature 463, 88–92
(07 January 2010); doi:10.1038/nature08638
| Full Text (HTML / PDF) |
letter
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
Martin Schwickart et al.
Nature 463, 103–107
(07 January 2010); doi:10.1038/nature08646
| Full Text (HTML / PDF) |
letter
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
Wenjun Zhou et al.
Nature 462, 1070–1074
(24 December 2009); doi:10.1038/nature08622
| Full Text (HTML / PDF) |
review
Leukaemogenesis: more than mutant genes
Jianjun Chen, Olatoyosi Odenike & Janet D. Rowley
Nature Reviews Cancer 10, 23–36
(January 2010); doi:10.1038/nrc2765
| Summary | Full Text (HTML / PDF) |
review
Senescence in tumours: evidence from mice and humans
Manuel Collado & Manuel Serrano
Nature Reviews Cancer 10, 51–57
(January 2010); doi:10.1038/nrc2772
| Summary | Full Text (HTML / PDF) |
|
