article Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy
Motoaki Sano, Maha Abdellatif, Hidemasa Oh, Min Xie, Luigi Bagella, Antonio Giordano, Lloyd H. Michael, Francesco J. DeMayo and Michael D. Schneider Nature Medicine8, 1310–1317
(November 2002); doi:10.1038/nm778
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August
letters to nature Reverse engineering of the giant muscle protein titin
Hongbin Li, Wolfgang A. Linke, Andres F. Oberhauser, Mariano Carrion-Vazquez, Jason G. Kerkvliet, Hui Lu, Piotr E. Marszalek and Julio M. Fernandez Nature418, 998–1002
(29 August 2002); doi:10.1038/nature00938
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article Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: A genetic predisposition to viral heart disease
Dingding Xiong, Gil-Hwan Lee, Cornel Badorff, Andrea Dorner, Sang Lee, Paul Wolf and Kirk U. Knowlton Nature Medicine8, 872–877
(August 2002); doi:10.1038/nm737
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article Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
Todd D. Camenisch, Joyce A. Schroeder, Judy Bradley, Scott E. Klewer and John A. McDonald Nature Medicine8, 850–855
(August 2002); doi:10.1038/nm742
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letters to nature Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Petra Pandur, Matthias Läsche, Leonard M. Eisenberg and Michael Kühl Nature418, 636–641
(8 August 2002); doi:10.1038/nature00921
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article Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
Takayuki Shindo, Ichiro Manabe, Yasushi Fukushima, Kazuyuki Tobe, Kenichi Aizawa, Saku Miyamoto, Keiko Kawai-Kowase, Nobuo Moriyama, Yasushi Imai, Hayato Kawakami, Hiroaki Nishimatsu, Takashi Ishikawa, Toru Suzuki, Hiroyuki Morita, Koji Maemura, Masataka Sata, Yasunobu Hirata, Masayuki Komukai, Hiroyuki Kagechika, Takashi Kadowaki, Masahiko Kurabayashi and Ryozo Nagai Nature Medicine8, 856–863
(August 2002); doi:10.1038/nm738
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July
article Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy
Martin G. Yussman, Tsuyoshi Toyokawa, Amy Odley, Roy A. Lynch, Guangyu Wu, Melissa C. Colbert, Bruce J. Aronow, John N. Lorenz, Gerald W. Dorn and Gerald W. Dorn II Nature Medicine8, 725–730
(July 2002); doi:10.1038/nm719
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review article Organogenesis: Patterning the vertebrate heart
Richard P. Harvey Nature Reviews Genetics3, 544–556
(July 2002); doi:10.1038/nrg843
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June
article Angiotensin-converting enzyme 2 is an essential regulator of heart function
Michael A. Crackower, Renu Sarao, Gavin Y. Oudit, Chana Yagil, Ivona Kozieradzki, Sam E. Scanga, Antonio J. Oliveira-dos-Santos, Joan da Costa, Liyong Zhang, York Pei, James Scholey, Carlos M. Ferrario, Armen S. Manoukian, Mark C. Chappell, Peter H. Backx, Yoram Yagil and Josef M. Penninger Nature417, 822–828
(20 June 2002); doi:10.1038/nature00786
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May
article Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Takashi Miki, Masashi Suzuki, Tadao Shibasaki, Hiroko Uemura, Toshiaki Sato, Kaori Yamaguchi, Haruhiko Koseki, Toshihiko Iwanaga, Haruaki Nakaya and Susumu Seino Nature Medicine8, 466–472
(May 2002); doi:10.1038/nm0502-466
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letters to nature Extensive and divergent circadian gene expression in liver and heart
Kai-Florian Storch, Ovidiu Lipan, Igor Leykin, N. Viswanathan, Fred C. Davis, Wing H. Wong & Charles J. Weitz Nature 417, 78–83
(May 2002); doi:10.1038/nature744
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news and views Corticosteroids and cardioprotection
Christoph Thiemermann Nature Medicine8, 453–455
(May 2002); doi:10.1038/nm0502-453
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article A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis
Takahide Nagase, Naonori Uozumi, Satoshi Ishii, Yoshihiro Kita, Hiroshi Yamamoto, Eijiro Ohga, Yasuyoshi Ouchi and Takao Shimizu Nature Medicine8, 480–484
(May 2002); doi:10.1038/nm0502-480
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article Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
Ali Hafezi-Moghadam, Tommaso Simoncini, Zequan Yang, Florian P. Limbourg, Jean-Christophe Plumier, Michela C. Rebsamen, Chung-Ming Hsieh, Dao-Shan Chui, Kennard L. Thomas, Alyson J. Prorock, Victor E. Laubach, Michael A. Moskowitz, Brent A. French, Klaus Ley and James K. Liao Nature Medicine8, 473–479
(May 2002); doi:10.1038/nm0502-473
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article Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis
Paul D. Gottlieb, Stephanie A. Pierce, Robert J. Sims III, Hiroyuki Yamagishi, Elizabeth K. Weihe, June V. Harriss, Shanna D. Maika, William A. Kuziel, Heather L. King, Eric N. Olson, Osamu Nakagawa and Deepak Srivastava Nature Genetics31, 25–32
(May 2002); doi:10.1038/ng866
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article ErbB2 is essential in the prevention of dilated cardiomyopathy
Steven A. Crone, You-Yang Zhao, Lian Fan, Yusu Gu, Susumu Minamisawa, Yang Liu, Kirk L. Peterson, Ju Chen, Ronald Kahn, Gianluigi Condorelli, John Ross Jr, Kenneth R. Chien and Kuo-Fen Lee Nature Medicine8, 459–465
(May 2002); doi:10.1038/nm0502-459
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review article POTENTIAL CARDIOPROTECTIVE ACTIONS OF NO-RELEASING ASPIRIN
John L. Wallace, Louis J. Ignarro and Stefano Fiorucci Nature Reviews Drug Discovery1, 375–382
(May 2002); doi:10.1038/nrd794
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March
news and views Molecular physiology: Protecting the heart
Mark T. Nelson and Gerald M. Herrera Nature 416, 273–274
(March 2002); doi:10.1038/416273a
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letters to nature Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy
Hong-Bo Xin, Takaaki Senbonmatsu, Dong-Sheng Cheng, Yong-Xiao Wang, Julio A. Copello, Guang-Ju Ji, Mei Lin Collier, Ke-Yu Deng, Loice H. Jeyakumar, Mark A. Magnuson, Tadashi Inagami, Michael I. Kotlikoff and Sidney Fleischer Nature 416, 334–338
(March 2002); doi:10.1038/416334a
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January
article Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
Masanori Asakura, Masafumi Kitakaze, Seiji Takashima, Yulin Liao, Fuminobu Ishikura, Tsuyoshi Yoshinaka, Hiroshi Ohmoto, Koichi Node, Kohichiro Yoshino, Hiroshi Ishiguro, Hiroshi Asanuma, Shoji Sanada, Yasushi Matsumura, Hiroshi Takeda, Shintaro Beppu, Michihiko Tada, Masatsugu Hori and Shigeki Higashiyama Nature Medicine8, 35–40
(January 2002); doi:10.1038/nm0102-35
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news and views Shedding growth factors in cardiac hypertrophy
James K. Liao Nature Medicine8, 20–21
(January 2002); doi:10.1038/nm0102-20
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letters to nature A calcium sensor in the sodium channel modulates cardiac excitability
Hanno L. Tan, Sabina Kupershmidt, Rong Zhang, Svetlana Stepanovic, Dan M. Roden, Arthur A. M. Wilde, Mark E. Anderson and Jeffrey R. Balser Nature 415, 442–447
(January 2002); doi:10.1038/415442a
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insight Cardiac excitation-contraction coupling
Donald M. Bers Nature 415, 198–205
(January 2002); doi:10.1038/415198a
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insight Seven-transmembrane-spanning receptors and heart function
Howard A. Rockman, Walter J. Koch and Robert J. Lefkowitz Nature 415, 206–212
(January 2002); doi:10.1038/415206a
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