letter Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling
Toshihiko Toyofuku, Hong Zhang, Atsushi Kumanogoh, Noriko Takegahara, Masanori Yabuki, Koichiro Harada, Masatsugu Hori and Hitoshi Kikutani Nature Cell Biology6, 1204–1211
(December 2004); doi:10.1038/ncb1193
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news and views Invasive growth: A two-way street for semaphorin signalling
Paolo M. Comoglio, Luca Tamagnone and Silvia Giordano Nature Cell Biology6, 1155–1157
(December 2004); doi:10.1038/ncb1204-1155
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letter Adiponectin-mediated modulation of hypertrophic signals in the heart
Rei Shibata, Noriyuki Ouchi, Masahiro Ito, Shinji Kihara, Ichiro Shiojima, David R Pimentel, Masahiro Kumada, Kaori Sato, Stephan Schiekofer, Koji Ohashi, Tohru Funahashi, Wilson S Colucci and Kenneth Walsh Nature Medicine10, 1384–1389
(December 2004); doi:10.1038/nm1137
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article Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress
Norbert Frey, Tomasa Barrientos, John M Shelton, Derk Frank, Hartmut Rütten, Doris Gehring, Christian Kuhn, Matthias Lutz, Beverly Rothermel, Rhonda Bassel-Duby, James A Richardson, Hugo A Katus, Joseph A Hill and Eric N Olson Nature Medicine10, 1336–1343
(December 2004); doi:10.1038/nm1132
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article Insulin regulation of heart function in aging fruit flies
Robert J Wessells, Erin Fitzgerald, James R Cypser, Marc Tatar and Rolf Bodmer Nature Genetics36, 1275–1281
(December 2004); doi:10.1038/ng1476
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November
article Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Ildiko Bock-Marquette , Ankur Saxena , Michael D. White, J. Michael DiMaio and Deepak Srivastava Nature432, 466–472
(25 November 2004); doi:10.1038/nature03000
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news and views Regenerative medicine: Prometheus unbound
Michael D. Schneider Nature432, 451–453
(25 November 2004); doi:10.1038/432451a
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letter Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
Lihong Cheng, Guoliang Ding, Qianhong Qin, Yao Huang, William Lewis, Nu He, Ronald M Evans, Michael D Schneider, Florence A Brako, Yan Xiao, Yuqing E Chen and Qinglin Yang Nature Medicine10, 1245–1250
(November 2004); doi:10.1038/nm1116
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review article Molecular genetics and genomics of heart failure
Choong-Chin Liew and Victor J. Dzau Nature Reviews Genetics5, 811–825
(November 2004); doi:10.1038/nrg1470
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letters to nature Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
Heiko Lickert, Jun K. Takeuchi , Ingo von Both, Johnathon R. Walls, Fionnuala McAuliffe, S. Lee Adamson , R. Mark Henkelman, Jeffrey L. Wrana, Janet Rossant and Benoit G. Bruneau Nature432, 107–112
(04 November 2004); doi:10.1038/nature03071
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October
September
letter Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
Lolitika Mandal, Utpal Banerjee and Volker Hartenstein Nature Genetics36, 1019–1023
(September 2004); doi:10.1038/ng1404
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news and views Unravelling Ras signals in cardiovascular disease
Kenneth R. Chien and Masahiko Hoshijima Nature Cell Biology6, 807–808
(September 2004); doi:10.1038/ncb0904–807
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article The 5–lipoxygenase pathway promotes pathogenesis of hyperlipidemia–dependent aortic aneurysm
Lei Zhao, Michael P W Moos, Rolf Gräbner, Frédérique Pédrono, Jinjin Fan, Brigitte Kaiser, Nicole John, Sandra Schmidt, Rainer Spanbroek, Katharina Lötzer, Li Huang, Jisong Cui, Daniel J Rader, Jilly F Evans, Andreas J R Habenicht and Colin D Funk Nature Medicine10, 966–973
(September 2004); doi:10.1038/nm1099
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news and views Aneurysms: leukotrienes weaken aorta from the outside
Wulf Palinski Nature Medicine10, 896–898
(September 2004); doi:10.1038/nm0904–896
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August
article Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
Toshiyuki Araki, M Golam Mohi, Fraz A Ismat, Roderick T Bronson, Ifor R Williams, Jeffery L Kutok, Wentian Yang, Lily I Pao, D Gary Gilliland, Jonathan A Epstein and Benjamin G Neel Nature Medicine10, 849–857
(August 2004); doi:10.1038/nm1084
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July
review article Novel therapeutic approaches for heart failure by normalizing calcium cycling
Xander H. T. Wehrens and Andrew R. Marks Nature Reviews Drug Discovery3, 565–574
(July 2004); doi:10.1038/nrd1440
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June
news and views Heart disease: An ongoing genetic battle?
Deepak Srivastava Nature429, 819–822
(24 June 2004); doi:10.1038/429819a
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letter 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone
Thomas S Scanlan, Katherine L Suchland, Matthew E Hart, Grazia Chiellini, Yong Huang, Paul J Kruzich, Sabina Frascarelli, Dane A Crossley, II James R Bunzow, Simonetta Ronca-Testoni, Emil T Lin, Daniel Hatton, Riccardo Zucchi and David K Grandy Nature Medicine10, 638–642
(June 2004); doi:10.1038/nm1051
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news and views The two-timing thyroid
Stephen B Liggett Nature Medicine10, 582–583
(June 2004); doi:10.1038/nm0604-582
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research article Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
Gerold Schmitt-Ulms, Kirk Hansen, Jialing Liu, Cynthia Cowdrey, Jian Yang, Stephen J DeArmond, Fred E Cohen, Stanley B Prusiner and Michael A Baldwin Nature Biotechnology22, 724–731
(June 2004); doi:10.1038/nbt969
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article Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita and Issei Komuro Nature Cell Biology6, 499–506
(June 2004); doi:10.1038/ncb1137
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May
letters to nature Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro
Kouichi Ozaki, Katsumi Inoue, Hiroshi Sato, Aritoshi Iida, Yozo Ohnishi, Akihiro Sekine, Hideyuki Sato, Keita Odashiro, Masakiyo Nobuyoshi, Masatsugu Hori, Yusuke Nakamura and Toshihiro Tanaka Nature429, 72–75
(06 May 2004); doi:10.1038/nature02502
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April
letter Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
Harry Björkbacka, Vidya V Kunjathoor, Kathryn J Moore, Stephanie Koehn, Christine M Ordija, Melinda A Lee, Terry Means, Kristen Halmen, Andrew D Luster, Douglas T Golenbock and Mason W Freeman Nature Medicine10, 416–421
(April 2004); doi:10.1038/nm1008
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letters to nature Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry, Mark H. Soonpaa, Hans Reinecke, Hidehiro Nakajima, Hisako O. Nakajima, Michael Rubart, Kishore B. S. Pasumarthi, Jitka Ismail Virag, Stephen H. Bartelmez, Veronica Poppa, Gillian Bradford, Joshua D. Dowell, David A. Williams and Loren J. Field Nature428, 664–668
(08 April 2004); doi:10.1038/nature02446
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letters to nature Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Leora B. Balsam, Amy J. Wagers, Julie L. Christensen, Theo Kofidis, Irving L. Weissman and Robert C. Robbins Nature428, 668–673
(08 April 2004); doi:10.1038/nature02460
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news and views Stem cells: Lost in translation
Kenneth R. Chien Nature428, 607–608
(08 April 2004); doi:10.1038/nature02500
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letter ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
Martin Bienengraeber, Timothy M Olson, Vitaliy A Selivanov, Eva C Kathmann, Fearghas O'Cochlain, Fan Gao, Amy B Karger, Jeffrey D Ballew, Denice M Hodgson, Leonid V Zingman, Yuan-Ping Pang, Alexey E Alekseev and Andre Terzic Nature Genetics36, 382–387
(April 2004); doi:10.1038/ng1329
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March
article PKC-α regulates cardiac contractility and propensity toward heart failure
Julian C Braz, Kimberly Gregory, Anand Pathak, Wen Zhao, Bogachan Sahin, Raisa Klevitsky, Thomas F Kimball, John N Lorenz, Angus C Nairn, Stephen B Liggett, Ilona Bodi, Su Wang, Arnold Schwartz, Edward G Lakatta, Anna A DePaoli-Roach, Jeffrey Robbins, Timothy E Hewett, James A Bibb, Margaret V Westfall, Evangelia G Kranias and Jeffery D Molkentin Nature Medicine10, 248–254
(March 2004); doi:10.1038/nm1000
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news and views Calcium handler mishandles heart
Hunter C Champion and David A Kass Nature Medicine10, 239–240
(March 2004); doi:10.1038/nm0304-239
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article The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Anna Helgadottir, Andrei Manolescu, Gudmar Thorleifsson, Solveig Gretarsdottir, Helga Jonsdottir, Unnur Thorsteinsdottir, Nilesh J Samani, Gudmundur Gudmundsson, Struan F A Grant, Gudmundur Thorgeirsson, Sigurlaug Sveinbjornsdottir, Einar M Valdimarsson, Stefan E Matthiasson, Halldor Johannsson, Olof Gudmundsdottir, Mark E Gurney, Jesus Sainz, Margret Thorhallsdottir, Margret Andresdottir, Michael L Frigge, Eric J Topol, Augustine Kong, Vilmundur Gudnason, Hakon Hakonarson, Jeffrey R Gulcher & Kari Stefansson Nature Genetics36, 233–239
(March 2004); doi:10.1038/ng1311
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article An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability
Tammy L Wingo, Vikas N Shah, Mark E Anderson, Terry P Lybrand, Walter J Chazin and Jeffrey R Balser Nature Structural and Molecular Biology11, 219–225
(March 2004); doi:10.1038/nsmb737
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February
letters to nature Multiple transport modes of the cardiac Na+/Ca2+ exchanger
Tong Mook Kang and Donald W. Hilgemann Nature427, 544–548
(05 February 2004); doi:10.1038/nature02271
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letter FRET between cardiac Na+ channel subunits measured with a confocal microscope and a streak camera
Christoph Biskup, Thomas Zimmer and Klaus Benndorf Nature Biotechnology22, 220–224
(February 2004) ; doi:10.1038/nbt935
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