Research library: Cell cycle / DNA repair
2002: December | November
| October | September
| August | July
| June | May
| April | March
| February | January
Other Years: 2003 | 2004 | 2005 | 2006 | 2007 | 2008
December
brief communication
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J. Romanienko, Julio C. Morales, Kazuhito Naka, Zhenfang Xia, R. Daniel Camerini-Otero, Noboru Motoyama, Phillip B. Carpenter, William M. Bonner, Junjie Chen and André Nussenzweig
Nature Cell Biology 4, 993–997
(December 2002); doi:10.1038/ncb884
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brief communication
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
Richard A. DiTullio, Jr Tamara A. Mochan, Monica Venere, Jirina Bartkova, Maxwell Sehested, Jiri Bartek and Thanos D. Halazonetis
Nature Cell Biology 4, 998–1002
(December 2002); doi:10.1038/ncb892
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news and views
Checkpoint signalling: focusing on 53BP1
Robert T. Abraham
Nature Cell Biology 4, E277
(December 2002); doi:10.1038/ncb1202-e277
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review article
The retinoblastoma tumour suppressor in development and cancer
Marie Classon and Ed Harlow
Nature Reviews Cancer 2, 910–917
(December 2002); doi:10.1038/nrc950
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brief communication
Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis
Antonio Baonza, Christopher M. Murawsky, Andrew A. Travers and Matthew Freeman
Nature Cell Biology 4, 976–980
(December 2002); doi:10.1038/ncb887
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November
article
Direct coupling of the cell cycle and cell death machinery by E2F
Zaher Nahle, Julia Polakoff, Ramana V. Davuluri, Mila E. McCurrach, Matthew D. Jacobson, Masashi Narita, Michael Q. Zhang, Yuri Lazebnik, Dafna Bar-Sagi and Scott W. Lowe
Nature Cell Biology 4, 859–864
(November 2002); doi:10.1038/ncb868
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article
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
Stephen A. Migueles, Alisha C. Laborico, W. Lesley Shupert, M. Shirin Sabbaghian, Ronald Rabin, Claire W. Hallahan, Debbie Van Baarle, Stefan Kostense, Frank Miedema, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu and Mark Connors
Nature Immunology 3, 1061–1068
(November 2002); doi:10.1038/ni845
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news and views
Developmental biology: Colon construction
Mark Peifer
Nature 420, 274–276
(21 November 2002); doi:10.1038/420274a
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article
The Doc1 subunit is a processivity factor for the anaphase-promoting complex
Christopher W. Carroll and David O. Morgan
Nature Cell Biology 4, 880–887
(November 2002); doi:10.1038/ncb871
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article
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
Shutong Yang, Christin Kuo, John E. Bisi and Myung K. Kim
Nature Cell Biology 4, 865–870
(November 2002); doi:10.1038/ncb869
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news and views
Chk2 leaves the PML depot
Monica Venere, Tamara A. Mochan and Thanos D. Halazonetis
Nature Cell Biology 4, E255
(November 2002); doi:10.1038/ncb1102-e255
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October
letters to nature
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
Hongwu Zheng, Han You, Xiao Zhen Zhou, Stephen A. Murray, Takafumi Uchida, Gerburg Wulf, Ling Gu, Xiaoren Tang, Kun Ping Lu and Zhi-Xiong Jim Xiao
Nature 419, 849–853
(24 October 2002); doi:10.1038/nature01116
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letters to nature
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
Paola Zacchi , Monica Gostissa, Takafumi Uchida, Clio Salvagno, Fabio Avolio, Stefano Volinia, Ze'ev Ronai, Giovanni Blandino, Claudio Schneider and Giannino Del Sal
Nature 419, 853–857
(24 October 2002); doi:10.1038/nature01120
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news and views
Cancer: Pinning a change on p53
Kevin M. Ryan and Karen H. Vousden An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.
Nature 419, 795–797
(24 October 2002); doi:10.1038/419795a
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article
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
Giuseppe Viglietto, Maria Letizia Motti, Paola Bruni, Rosa Marina Melillo, Amelia D'Alessio, Daniela Califano, Floriana Vinci, Gennaro Chiappetta, Philip Tsichlis, Alfonso Bellacosa, Alfredo Fusco and Massimo Santoro
Nature Medicine 8, 1136–1144
(October 2002); doi:10.1038/nm762
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article
PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization
Incheol Shin, F Michael Yakes, Federico Rojo, Nah-Young Shin, Andrei V. Bakin, Jose Baselga and Carlos L. Arteaga
Nature Medicine 8, 1145–1152
(October 2002); doi:10.1038/nm759
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article
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
Jiyong Liang, Judit Zubovitz, Teresa Petrocelli, Rouslan Kotchetkov, Michael K. Connor, Kathy Han, Jin-Hwa Lee, Sandra Ciarallo, Charles Catzavelos, Richard Beniston, Edmee Franssen and Joyce M. Slingerland
Nature Medicine 8, 1153–1160
(October 2002); doi:10.1038/nm761
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news and views
Breast cancer banishes p27 from nucleus
Stacy W. Blain and Joan Massagué
Nature Medicine 8, 1076–1078
(October 2002); doi:10.1038/nm1002-1076
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review article
c-myc: more than just a matter of life and death
Stella Pelengaris, Mike Khan and Gerard Evan
Nature Reviews Cancer 2, 764–776
(October 2002); doi:10.1038/nrc904
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letter
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization
Genie C. Leung, John W. Hudson, Anna Kozarova, Alan Davidson, James W. Dennis and Frank Sicheri
Nature Structural Biology 9, 719–724
(October 2002); doi:10.1038/nsb848
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letter
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
Juan A. Bernal, Rosa Luna, Águeda Espina, Icíar Lázaro, Francisco Ramos-Morales, Francisco Romero, Carmen Arias, Augusto Silva, María Tortolero and José A. Pintor-Toro
Nature Genetics 32, 306–311
(October 2002); doi:10.1038/ng997
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news and views
Securin a new role for itself
Anil K. Rustgi
Nature Genetics 32, 222–224
(October 2002); doi:10.1038/ng1002-222
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brief communication
Astral microtubules monitor metaphase spindle alignment in fission yeast
Snezhana Oliferenko and Mohan K. Balasubramanian
Nature Cell Biology 4, 816–820
(October 2002); doi:10.1038/ncb861
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news and views
First things first: spindle orientation and mitotic progression
Dannel McCollum
Nature Cell Biology 4, E225
(October 2002); doi:10.1038/ncb1002-e225
| Full Text (HTML/PDF) |
review article
The spindle checkpoint: structural insights into dynamic signalling
Andrea Musacchio and Kevin G. Hardwick
Nature Reviews Molecular Cell Biology 3, 731–741
(October 2002); doi:10.1038/nrm929
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article
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Mirella Lazarov, Yoshiaki Kubo, Ti Cai, Maya Dajee, Masahito Tarutani, Qun Lin, Min Fang, Shiying Tao, Cheryl L. Green and Paul A. Khavari
Nature Medicine 8, 1105–1114
(October 2002); doi:10.1038/nm779
| Abstract | Full Text (HTML/PDF) |
September
article
The harlequin mouse mutation downregulates apoptosis-inducing factor
Jeffrey A. Klein, Chantal M. Longo-Guess, Marlies P. Rossmann, Kevin L. Seburn, Ronald E. Hurd, Wayne N. Frankel, Roderick T. Bronson and Susan L. Ackerman
Nature 419, 367–374
(26 September 2002); doi:10.1038/nature01034
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article
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
Carsten Hoege, Boris Pfander, George-Lucian Moldovan, George Pyrowolakis and Stefan Jentsch
Nature 419, 135–141
(12 September 2002); doi:10.1038/nature00991
| Summary | Full Text (HTML / PDF) |
news and views
DNA repair: Right on target with ubiquitin
Cecile M. Pickart Cellular DNA-repair mechanisms prevent mutations from accumulating, thereby averting defects in cell function. A molecule best known for its role in protein degradation is now shown to have a specific task in DNA repair.
Nature 419, 120–121
(12 September 2002); doi:10.1038/419120a
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letter
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice
Anders H. Lund, Geoffrey Turner, Alla Trubetskoy, Els Verhoeven, Ellen Wientjens, Danielle Hulsman, Robert Russell, Ronald A. DePinho, Jack Lenz and Maarten van Lohuizen
Nature Genetics 32, 160–165
(September 2002); doi:10.1038/ng956
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August
news and views
Chromosome instability: lessons from HIV
Jan Paul Medema and René H. Medema
Nature Cell Biology 4, E191
(August 2002); doi:10.1038/ncb0802-e191b
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review article
CDKS and CKIS: Molecular targets for tissue remodelling
Elizabeth G. Nabel
Nature Reviews Drug Discovery 1, 587–598
(August 2002); doi:10.1038/nrd869
| Summary | Full Text (HTML / PDF) |
meeting report
Cell cycling? Check your brakes
Steven I. Reed
Nature Cell Biology 4, E199
(August 2002); doi:10.1038/ncb0802-e199
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review article
Plasticity and reprogramming of differentiated cells in amphibian regeneration
Jeremy P. Brockes and Anoop Kumar
Nature Reviews Molecular Cell Biology 3, 566–574
(August 2002); doi:10.1038/nrm881
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letter
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit
Ralph Wäsch and Frederick R. Cross
Nature 418, 556–562
(1 August 2002); doi:10.1038/nature00856
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news and views
Cell cycle: Oscillation sensation
David O. Morgan and James M. Roberts
Nature 418, 495–496
(1 August 2002); doi:10.1038/418495a
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article
Molecular interpretation of ERK signal duration by immediate early gene products
Leon O. Murphy, Sallie Smith, Rey-Huei Chen, Diane C. Fingar and John Blenis
Nature Cell Biology 4, 556–564
(August 2002); doi:10.1038/ncb822
| Abstract | Full Text (HTML/PDF) |
news and views
Common sense signalling
Richard K. Assoian
Nature Cell Biology 4, E187
(August 2002); doi:10.1038/ncb0802-e187
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July
brief communication
Distinct roles for cyclins E and A during DNA replication complex assembly and activation
D Coverley, H Laman & R A Laskey
Nature Cell Biology 4, 523–528
(July 2002); doi:10.1038/ncb813
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letter to nature
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
Travis H. Stracker, Christian T. Carson and Matthew D. Weitzman
Nature 418, 348–352
(18 July 2002); doi:10.1038/nature00863
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review article
The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
Martin Hetzer, Oliver J. Gruss and Iain W. Mattaj
Nature Cell Biology 4, E177
(July 2002); doi:10.1038/ncb0702-e177
| Abstract | Full Text (HTML/PDF) |
news and views
Efp: A ring of independence?
Grzegorz Nalepa and J. Wade Harper
Nature Medicine 8, 661–662
(July 2002); doi:10.1038/nm0702-661
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June
letter
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry
Marina Lomazzi, M. Cristina Moroni, Michael R. Jensen, Emanuela Frittoli and Kristian Helin
Nature Genetics 31, 190–194
(June 2002); doi:10.1038/ng891
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news and views
Mini p53
Valerie Ferrier
Nature Cell Biology 4, E156
(June 2002); doi:10.1038/ncb0602-e156
| Full Text (HTML/PDF) |
meeting report
Life and death in paradise
Or Gozani, Michael Boyce, Lina Yoo, Philip Karuman and Junying Yuan
Nature Cell Biology 4, E159
(June 2002); doi:10.1038/ncb0602-e159
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letter
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
Dmitry V. Bulavin, Oleg N. Demidov, Shin'ichi Saito, Paivikki Kauraniemi, Crissy Phillips, Sally A. Amundson, Concetta Ambrosino, Guido Sauter, Angel R. Nebreda, Carl W. Anderson, Anne Kallioniemi, Albert J. Fornace Jr & Ettore Appella
Nature Genetics 31, 210–215
(June 2002); doi:10.1038/ng894
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May
article
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1
Jerry Y. Hsu, Julie D.R. Reimann, Claus S. Sørensen, Jiri Lukas and Peter K. Jackson
Nature Cell Biology 4, 358–366
(May 2002); doi:10.1038/ncb785
| Abstract | Full Text (HTML/PDF) |
news and views
Conspiracy to disarm APC in interphase
Hartmut C. Vodermaier and Jan-Michael Peters
Nature Cell Biology 4, E119
(May 2002); doi:10.1038/ncb0502-e119
| Full Text (HTML/PDF) |
letter
Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations
Hanne Meijers-Heijboer, Ans van den Ouweland, Jan Klijn, Marijke Wasielewski, Anja de Snoo, Rogier Oldenburg, Antoinette Hollestelle, Mark Houben, Ellen Crepin, Monique van Veghel-Plandsoen, Fons Elstrodt, Cornelia van Duijn, Carina Bartels, Carel Meijers, Mieke Schutte, Lesley McGuffog, Deborah Thompson, Douglas F. Easton, Nayanta Sodha, Sheila Seal, Rita Barfoot, Jon Mangion, Jenny Chang-Claude, Diana Eccles, Rosalind Eeles, D Gareth Evans, Richard Houlston, Victoria Murday, Steven Narod, Tamara Peretz, Julian Peto, Catherine Phelan, Hong Xiang Zhang, Csilla Szabo, Peter Devilee, David Goldgar, P Andrew Futreal, Katherine L. Nathanson, Barbara L. Weber, Nazneen Rahman and Michael R. Stratton
Nature Genetics 31, 55–59
(May 2002); doi:10.1038/ng879
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news and views
CHEKs and balances: accounting for breast cancer
Lawrence C. Brody
Nature Genetics 31, 3–4
(May 2002); doi:10.1038/ng0502-3
| Full Text (HTML/PDF) |
brief communication
Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p
Hiroshi Murakami, Stephanie K. Yanow, Dominic Griffiths, Makoto Nakanishi and Paul Nurse
Nature Cell Biology 4, 384–388
(May 2002); doi:10.1038/ncb789
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review article
The mre11 complex: at the crossroads of dna repair and checkpoint signalling
Damien D'Amours and Stephen P. Jackson
Nature Reviews Molecular Cell Biology 3, 317–327
(May 2002); doi:10.1038/nrm805
| Abstract | Full Text (HTML/PDF) |
April
letters to nature
Emi1 is required for cytostatic factor arrest in vertebrate eggs
Julie D. R. Reimann and Peter K. Jackson
Nature 416, 850–854
(April 2002); doi:10.1038/416850a
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letters to nature
Emi1 is required for cytostatic factor arrest in vertebrate eggs
Julie D. R. Reimann and Peter K. Jackson
Nature 416, 850–854
(April 2002); doi:10.1038/416850a
| First Paragraph | Full Text (HTML/PDF) |
news and views
Developmental biology: An arresting activity
Nicholas S. Duesbery and George F. Vande Woude
Nature 416, 804–805
(April 2002); doi:10.1038/416804a
| Full Text (HTML/PDF) |
brief communication
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
Niels Mailand, Claudia Lukas, Brett K. Kaiser, Peter K. Jackson, Jiri Bartek and Jiri Lukas
Nature Cell Biology 4, 318–322
(April 2002); doi:10.1038/ncb777
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letter
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation
A. Jeannine Lincoln, Dineli Wickramasinghe, Paula Stein, Richard M. Schultz, Mary Ellen Palko, Maria P. De De Miguel, Lino Tessarollo and Peter J. Donovan
Nature Genetics 30, 446–449
(April 2002); doi:10.1038/ng856
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March
letter
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
Ronit I. Yarden, Sherly Pardo-Reoyo, Magda Sgagias, Kenneth H. Cowan and Lawrence C. Brody
Nature Genetics 30, 285–289
(March 2002); doi:10.1038/ng837
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letter
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
Jacob Falck, John H.J. Petrini, Bret R. Williams, Jiri Lukas and Jiri Bartek
Nature Genetics 30, 290–294
(March 2002); doi:10.1038/ng845
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February
review article
DEADLY ENCOUNTER: UBIQUITIN MEETS APOPTOSIS
Veronika Jesenberger and Stefan Jentsch
Nature Reviews Molecular Cell Biology 3, 112–121
(February 2002); doi:10.1038/nrm731
| Abstract | Full Text (HTML/PDF) |
commentary
Limits to lifespan
Alison C. Lloyd
Nature Cell Biology 4, E25
(February 2002); doi:10.1038/ncb0202-e25
| Full Text (HTML/PDF) |
article
Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition
Eiichi Okumura, Takeshi Fukuhara, Hitoshi Yoshida, Shin-ichiro Hanada, Rie Kozutsumi, Masashi Mori, Kazunori Tachibana and Takeo Kishimoto
Nature Cell Biology 4, 111–116
(February 2002); doi:10.1038/ncb741
| Abstract | Full Text (HTML/PDF) |
brief communication
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
Daniel S. Peeper, Avi Shvarts, Thijn Brummelkamp, Sirith Douma, Eugene Y. Koh, George Q. Daley and René Bernards
Nature Cell Biology 4, 148–153
(February 2002); doi:10.1038/ncb742
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letters to nature
S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
Hiroshi Masumoto, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki
Nature 415, 651–655
(February 2002); doi:10.1038/nature713
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January
letter
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
Gerard Zambetti and Richard W. Kriwacki
Nature Structural Biology 9, 12–16
(January 2002); doi:10.1038/nsb730
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letters to nature
Phospholipase Cg1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
Keqiang Ye, Bahman Aghdasi, Hongbo R. Luo, John L. Moriarity, Frederick Y. Wu, Jenny J. Hong, K. Joseph Hurt, Sun Sik Bae, Pann-Ghill Suh and Solomon H. Snyder
Nature 415, 541–544
(January 2002); doi:10.1038/415541a
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