Research library: Clinical / Drug discovery
2002: December
| November
| October
| September
| August
| July
| June
| May
| April
| March
| February
| January
Other Years: 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009
December
article
Serum insulin-like growth factor I regulates brain amyloid-β levels
E. Carro, J.L. Trejo, T. Gomez-Isla, D. LeRoith and I. Torres-Aleman
Nature Medicine 8, 1390–1397
(December 2002); doi:10.1038/nm793
| Abstract | Full Text (HTML/PDF) |
article
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
Yonglian Sun, Helen M. Chen, Sumit K. Subudhi, Jonathan Chen, Rima Koka, Lieping Chen and Yang-Xin Fu
Nature Medicine 8, 1405–1413
(December 2002); doi:10.1038/nm796
| Abstract | Full Text (HTML/PDF) |
news and views
Immunotherapy tackles lupus
Gary M. Kammer
Nature Medicine 8, 1356–1358
(December 2002); doi:10.1038/nm1202-1356
| Full Text (HTML/PDF) |
article
The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs
Alon Chen, Yonatan Ganor, Shai Rahimipour, Nurit Ben-Aroya, Yitzhak Koch and Mia Levite
Nature Medicine 8, 1421–1426
(December 2002); doi:10.1038/nm801
| Abstract | Full Text (HTML/PDF) |
review article
The many faces of tumor necrosis factor in stroke
John M. Hallenbeck
Nature Medicine 8, 1363–1368
(December 2002); doi:10.1038/nm1202-1363
| Full Text (HTML/PDF) |
review article
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
Teru Hideshima and Kenneth C. Anderson
Nature Reviews Cancer 2, 927–937
(December 2002); doi:10.1038/nrc952
| Summary | Full Text (HTML / PDF) |
review article
New therapeutics that antagonize endothelin: promises and frustrations
Giuseppe Remuzzi , Norberto Perico and Ariela Benigni
Nature Reviews Drug Discovery 1, 986–1001
(December 2002); doi:10.1038/nrd962
| Summary | Full Text (HTML / PDF) |
article
A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth
Andreas G. Niethammer, Rong Xiang, Jürgen C. Becker, Harald Wodrich, Ursula Pertl, Gabriele Karsten, Brian P. Eliceiri and Ralph A. Reisfeld
Nature Medicine 8, 1369–1375
(December 2002); doi:10.1038/nm794
| Abstract | Full Text (HTML/PDF) |
news and views
Vessel maneuvers: Vaccine targets tumor vasculature
Michael S. O'Reilly
Nature Medicine 8, 1352–1353
(December 2002); doi:10.1038/nm1202-1352
| | Full Text (HTML/PDF) |
review article
Dual-specificity phosphatases as targets for antineoplastic agents
Michael A. Lyon, Alexander P. Ducruet, Peter Wipf and John S. Lazo
Nature Reviews Drug Discovery 1, 961–976
(December 2002); doi:10.1038/nrd963
| Summary | Full Text (HTML / PDF) |
article
Induction of angiogenesis in a mouse model using engineered transcription factors
Edward J. Rebar, Yan Huang, Reed Hickey, Anjali K. Nath, David Meoli, Sameer Nath, Bingliang Chen, Lei Xu, Yuxin Liang, Andrew C. Jamieson, Lei Zhang, S Kaye Spratt, Casey C. Case, Alan Wolffe and Frank J. Giordano
Nature Medicine 8, 1427–1432
(December 2002); doi:10.1038/nm795
| Abstract | Full Text (HTML/PDF) |
news and views
Vessel maneuvers: Zinc fingers promote angiogenesis
Renata Pasqualini, Carlos F. Barbas and III Wadih Arap
Nature Medicine 8, 1353–1354
(December 2002); doi:10.1038/nm1202-1353
| Full Text (HTML/PDF) |
review article
Oncolytic viruses
E. Antonio Chiocca
Nature Reviews Cancer 2, 938–950
(December 2002); doi:10.1038/nrc948
| Summary | Full Text (HTML / PDF) |
review article
Blocking NO synthesis: how, where and why?
Patrick Vallance and James Leiper
Nature Reviews Drug Discovery 1, 939–950
(December 2002); doi:10.1038/nrd960
| Summary | Full Text (HTML / PDF) |
November
letters to nature
Functional improvement of dystrophic muscle by myostatin blockade
Sasha Bogdanovich, Thomas O. B. Krag, Elisabeth R. Barton, Linda D. Morris, Lisa-Anne Whittemore, Rexford S. Ahima and Tejvir S. Khurana
Nature 420, 418–421
(28 November 2002); doi:10.1038/nature01154
| First Paragraph | Full Text (HTML / PDF) |
review article
Platelets in atherothrombosis
Zaverio M. Ruggeri
Nature Medicine 8, 1227–1234
(November 2002); doi:10.1038/nm1102-1227
| Abstract | Full Text (HTML/PDF) |
review
Neuroprotective and neurorestorative strategies for Parkinson's disease
Ted M. Dawson and Valina L. Dawson
Nature Neuroscience 5, 1058–1061
(November 2002); doi:10.1038/nn941
| Abstract | Full Text (HTML/PDF) |
review article
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
Frank M. LaFerla
Nature Reviews Neuroscience 3, 862–872
(November 2002); doi:10.1038/nrn960
| Summary | Full Text (HTML / PDF) |
review article
Hepatitis C therapeutics: current status and emerging strategies
Seng-Lai Tan, Arnim Pause, Yuguang Shi and Nahum Sonenberg
Nature Reviews Drug Discovery 1, 867–881
(November 2002); doi:10.1038/nrd937
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Super p53
Barbara Marte
Nature 420, 279
(21 November 2002); doi:10.1038/420279a
| Full Text (HTML / PDF) |
article
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Mauro Perretti, Nan Chiang, Mylinh La, Iolanda M. Fierro, Stefano Marullo, Stephen J Getting, Egle Solito and Charles N. Serhan
Nature Medicine 8, 1296–1302
(November 2002); doi:10.1038/nm786
| Abstract | Full Text (HTML/PDF) |
review
Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches
Hans Thoenen and Michael Sendtner
Nature Neuroscience 5, 1046–1050
(November 2002); doi:10.1038/nn938
| First Paragraph | Full Text (HTML/PDF) |
review
Can we conquer pain?
Joachim Scholz and Clifford J. Woolf
Nature Neuroscience 5, 1062–1067
(November 2002); doi:10.1038/nn942
| First Paragraph | Full Text (HTML/PDF) |
review article
Designing peptide receptor agonists and antagonists
Victor J. Hruby
Nature Reviews Drug Discovery 1, 847–858
(November 2002); doi:10.1038/nrd939
| Summary | Full Text (HTML / PDF) |
news and views
Medicine: Lipid signals in pain control
Nicolas G. Bazan and Rod J. Flower
Nature 420, 135–138
(14 November 2002); doi:10.1038/420135a
| Full Text (HTML / PDF) |
review
NMDA receptor pathways as drug targets
John A. Kemp & Ruth M. McKernan
Nature Neuroscience 5, 1039–1042
(November 2002); doi:10.1038/nn936
| Abstract | Full Text (HTML/PDF) |
letters to nature
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
Sawsan Youssef, Olaf Stüve, Juan C. Patarroyo, Pedro J. Ruiz, Jennifer L. Radosevich, Eun Mi Hur, Manuel Bravo, Dennis J. Mitchell, Raymond A. Sobel, Lawrence Steinman and Scott S. Zamvil
Nature 420, 78–84
(07 November 2002); doi:10.1038/nature01158
| First Paragraph | Full Text (HTML / PDF) |
news and views
Medicine: Tackling multiple sclerosis
Hartmut Wekerle
Nature 420, 39–40
(07 November 2002); doi:10.1038/420039a
| Full Text (HTML / PDF) |
news and views
Converting p53 from a killer into a healer
Andrei V. Gudkov
Nature Medicine 8, 1196–1198
(November 2002); doi:10.1038/nm1102-1196
| Full Text (HTML/PDF) |
review article
The pathogenesis of pituitary tumours
Sylvia L. Asa and Shereen Ezzat
Nature Reviews Cancer 2, 836–849
(November 2002); doi:10.1038/nrc926
| Summary | Full Text (HTML / PDF) |
review article
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
Georg Dechant and Yves-Alain Barde
Nature Neuroscience 5, 1131–1136
(November 2002); doi:10.1038/nn1102-1131
| Abstract | Full Text (HTML/PDF) |
article
Functional PPAR-g receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas
Anthony P. Heaney, Manory Fernando, William H. Yong and Shlomo Melmed
Nature Medicine 8, 1281–1287
(November 2002); doi:10.1038/nm784
| Abstract | Full Text (HTML/PDF) |
October
article
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
L E Nelson, T Z Guo, J Lu, C B Saper, N P Franks & M Maze
Nature Neuroscience 5, 979–984
(October 2002); doi:10.1038/nn913
| First Paragraph | Full Text (HTML/PDF) |
news and views
General anesthesia research: aroused from a deep sleep?
Neil L. Harrison
Nature Neuroscience 5, 928–929
(October 2002); doi:10.1038/nn1002-928
| Full Text (HTML/PDF) |
review article
Discoveries, drugs and skeletal disorders
David Goltzman
Nature Reviews Drug Discovery 1, 784–796
(October 2002); doi:10.1038/nrd916
| Summary | Full Text (HTML/PDF) |
review article
G-Protein-coupled receptor oligomerization and its potential for drug discovery
Susan R. George, Brian F. O'Dowd and Samuel P. Lee
Nature Reviews Drug Discovery 1, 808–820
(October 2002); doi:10.1038/nrd913
| Summary | Full Text (HTML/PDF) |
review article
Transcription factors as targets for cancer therapy
James E. Darnell Jr,
Nature Reviews Cancer 2, 740–749
(October 2002); doi:10.1038/nrc906
| Summary | Full Text (HTML / PDF) |
review article
Toll-like receptors as potential therapeutic targets for multiple diseases
Claudia Zuany-Amorim, John Hastewell and Christoph Walker
Nature Reviews Drug Discovery 1, 797–807
(October 2002); doi:10.1038/nrd914
| Summary | Full Text (HTML / PDF) |
review article
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
Toby Lawrence, Derek A. Willoughby and Derek W. Gilroy
Nature Reviews Immunology 2, 787–795
(October 2002); doi:10.1038/nri915
| Summary | Full Text (HTML/PDF) |
article
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
Lidija Covic, Meghna Misra, Jehangir Badar, Christopher Singh and Athan Kuliopulos
Nature Medicine 8, 1161–1165
(October 2002); doi:10.1038/nm760
| First Paragraph | Full Text (HTML/PDF) |
news and views
Attacked from within, blood thins
Wadie F. Bahou
Nature Medicine 8, 1082–1083
(October 2002); doi:10.1038/nm1002-1082
| Full Text (HTML/PDF) |
article
A futile metabolic cycle activated in adipocytes by antidiabetic agents
Hong-Ping Guan, Yong Li, Mette Valentin Jensen, Christopher B. Newgard, Claire M. Steppan and Mitchell A. Lazar
Nature Medicine 8, 1122–1128
(October 2002); doi:10.1038/nm780
| First Paragraph | Full Text (HTML/PDF) |
review article
NF-κB regulation in the immune system
Qiutang Li and Inder M. Verma
Nature Reviews Immunology 2, 725–734
(October 2002); doi:10.1038/nri910
| Summary | Full Text (HTML / PDF) |
review article
Clinical translation of angiogenesis inhibitors
Robert Kerbel and Judah Folkman
Nature Reviews Cancer 2, 727–739
(October 2002); doi:10.1038/nrc905
| Summary | Full Text (HTML / PDF) |
review article
Structural biology of insulin and IGF1 receptors: implications for drug design
Pierre De Meyts and Jonathan Whittaker
Nature Reviews Drug Discovery 1, 769–783
(October 2002); doi:10.1038/nrd917
| Summary | Full Text (HTML / PDF) |
perspectives
Timeline: VEGF and the quest for tumour angiogenesis factors
Napoleone Ferrara
Nature Reviews Cancer 2, 795–803
(October 2002); doi:10.1038/nrc909
| Summary | Full Text (HTML / PDF) |
article
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
Minerva M. Carrasquillo, Andrew S. McCallion, Erik G. Puffenberger, Carl S. Kashuk, Nassim Nouri and Aravinda Chakravarti
Nature Genetics 32, 237–244
(October 2002); doi:10.1038/ng998
| Abstract | Full Text (HTML/PDF) |
September
commentary
A reevaluation of integrins as regulators of angiogenesis
Richard O. Hynes
Nature Medicine 8, 918–921
(September 2002); doi:10.1038/nm0902-918
| Full Text (HTML/PDF) |
review article
Why does remyelination fail in multiple sclerosis?
Robin J. M. Franklin
Nature Reviews Neuroscience 3, 705–714
(September 2002); doi:10.1038/nrn917
| Summary | Full Text (HTML / PDF) |
review article
Phosphodiesterase 5 inhibitors: current status and potential applications
David P. Rotella
Nature Reviews Drug Discovery 1, 674–682
(September 2002); doi:10.1038/nrd893
| Summary | Full Text (HTML / PDF) |
review article
Coeliac disease: dissecting a complex inflammatory disorder
Ludvig M. Sollid
Nature Reviews Immunology 2, 647–655
(September 2002); doi:10.1038/nri885
| Summary | Full Text (HTML / PDF) |
review article
Clinical proteomics: translating benchside promise into bedside reality
Emanuel F. Petricoin, Kathryn C. Zoon, Elise C. Kohn, J. Carl Barrett and Lance A. Liotta
Nature Reviews Drug Discovery 1, 683–695
(September 2002); doi:10.1038/nrd891
| Summary | Full Text (HTML / PDF) |
review article
Protein tyrosine phosphatase 1B inhibitors for diabetes
Theodore O. Johnson, Jacques Ermolieff and Michael R. Jirousek
Nature Reviews Drug Discovery 1, 696–709
(September 2002); doi:10.1038/nrd895
| Summary | Full Text (HTML / PDF) |
letters to nature
RNA aptamers as reversible antagonists of coagulation factor IXa
Christopher P. Rusconi, Elizabeth Scardino, Juliana Layzer, George A. Pitoc, Thomas L. Ortel, Dougald Monroe and Bruce A. Sullenger
Nature 419, 90–94
(05 September 2002); doi:10.1038/nature00963
| First Paragraph | Full Text (HTML / PDF) |
news and views
Medicine: RNA as drug and antidote
Edward Tuddenham
Nature 419, 23–24
(05 September 2002); doi:10.1038/419023a
| Full Text (HTML / PDF) |
article
Cross-primed CD8+ T cells mediate graft rejection via a distinct effector pathway
Anna Valujskikh, Olivier Lantz, Susanna Celli, Polly Matzinger and Peter S. Heeger
Nature Immunology 3, 844–851
(September 2002); doi:10.1038/ni831
| Abstract | Full Text (HTML/PDF) |
news and views
Transplantation—caught in the crossfire!
Herman Waldmann
Nature Immunology 3, 803–804
(September 2002); doi:10.1038/ni0902-803
| Full Text (HTML/PDF) |
article
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
Sang Heui Seo, Erich Hoffmann and Robert G. Webster
Nature Medicine 8, 950–954
(September 2002); doi:10.1038/nm757
| Abstract | Full Text (HTML/PDF) |
news and views
The makings of a killer
Peter Palese, Christopher F. Basler and Adolfo García-Sastre
Nature Medicine 8, 927–928
(September 2002); doi:10.1038/nm0902-927
| Full Text (HTML/PDF) |
review article
Strategies for mmp inhibition in cancer: innovations for the post-trial era
Christopher Mark Overall and Carlos López-Otín
Nature Reviews Cancer 2, 657–672
(September 2002); doi:10.1038/nrc884
| Summary | Full Text (HTML / PDF) |
August
article
Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: A genetic predisposition to viral heart disease
Dingding Xiong, Gil-Hwan Lee, Cornel Badorff, Andrea Dorner, Sang Lee, Paul Wolf and Kirk U. Knowlton
Nature Medicine 8, 872–877
(August 2002); doi:10.1038/nm737
| Abstract | Full Text (HTML/PDF) |
article
Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Zoltan A. Nagy, Bernd Hubner, Corinna Löhning, Robert Rauchenberger, Silke Reiffert, Elisabeth Thomassen-Wolf, Stefan Zahn, Sigmar Leyer, Eva M. Schier, Angelika Zahradnik, Christoph Brunner, Kurt Lobenwein, Benno Rattel, Michael Stanglmaier, Michael Hallek, Mark Wing, Steve Anderson, Matt Dunn, Titus Kretzschmar and Michael Tesar
Nature Medicine 8, 801–807
(August 2002); doi:10.1038/nm736
| Abstract | Full Text (HTML/PDF) |
news and views
DR's orders: Human antibody kills tumors by direct signaling
Dan L. Longo
Nature Medicine 8, 781–783
(August 2002); doi:10.1038/nm0802-781
| Full Text (HTML/PDF) |
article
Gene-expression profiles predict survival of patients with lung adenocarcinoma
David G. Beer, Sharon L.R. Kardia, Chiang-Ching Huang, Thomas J. Giordano, Albert M. Levin, David E. Misek, Lin Lin, Guoan Chen, Tarek G. Gharib, Dafydd G. Thomas, Michelle L. Lizyness, Rork Kuick, Satoru Hayasaka, Jeremy M.G. Taylor, Mark D. Iannettoni, Mark B. Orringer and Samir Hanash
Nature Medicine 8, 816–824
(August 2002); doi:10.1038/nm733
| Abstract | Full Text (HTML/PDF) |
letter
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H
Matthew C. Pickering, H. Terence Cook, Joanna Warren, Anne E. Bygrave, Jill Moss, Mark J. Walport and Marina Botto
Nature Genetics 31, 424–428
(August 2002); doi:10.1038/ng912
| First Paragraph | Full Text (HTML/PDF) |
news and views
Complement in glomerulonephritis
Thomas R. Welch
Nature Genetics 31, 333–334
(August 2002); doi:10.1038/ng933
| Full Text (HTML/PDF) |
review article
The use of constitutively active GPCRs in drug discovery and functional genomics
Derek T. Chalmers and Dominic P. Behan
Nature Reviews Drug Discovery 1, 599–608
(August 2002); doi:10.1038/nrd872
| Summary | Full Text (HTML / PDF) |
perspectives
Opinion: Gene therapy of severe combined immunodeficiencies
Alain Fischer, Salima Hacein-Bey and Marina Cavazzana-Calvo
Nature Reviews Immunology 2, 615–621
(August 2002); doi:10.1038/nri859
| Summary | Full Text (HTML / PDF) |
review article
Asthma: an epidemic of dysregulated immunity
Dale T. Umetsu, Jennifer J. McIntire, Omid Akbari, Claudia Macaubas and Rosemarie H. DeKruyff
Nature Immunology 3, 715–720
(August 2002); doi:10.1038/ni0802-715
| Abstract | Full Text (HTML/PDF) |
review article
The hare and the tortoise: an embryonic haematopoietic race
Isabelle Godin and Ana Cumano
Nature Reviews Immunology 2, 593–604
(August 2002); doi:10.1038/nri857
| Abstract | Full Text (HTML/PDF) |
article
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Aernout Luttun, Marc Tjwa, Lieve Moons, Yan Wu, Anne Angelillo-Scherrer, Fang Liao, Janice A. Nagy, Andrea Hooper, Josef Priller, Bert De Klerck, Veerle Compernolle, Evis Daci, Peter Bohlen, Mieke Dewerchin, Jean-Marc Herbert, Roy Fava, Patrick Matthys, Geert Carmeliet, Désiré Collen, Harold F. Dvorak, Daniel J. Hicklin and Peter Carmeliet
Nature Medicine 8, 831–840
(August 2002); doi:10.1038/nm731
| Abstract | Full Text (HTML/PDF) |
article
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment
Koichi Hattori, Beate Heissig, Yan Wu, Sergio Dias, Rafael Tejada, Barbara Ferris, Daniel J. Hicklin, Zhenping Zhu, Peter Bohlen, Larry Witte, Jan Hendrikx, Neil R. Hackett, Ronald G. Crystal, Malcolm A.S. Moore, Zena Werb, David Lyden and Shahin Rafii
Nature Medicine 8, 841–849
(August 2002); doi:10.1038/nm740
| Abstract | Full Text (HTML/PDF) |
news and views
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies
Ulf Eriksson and Kari Alitalo
Nature Medicine 8, 775–777
(August 2002); doi:10.1038/nm0802-775
| Full Text (HTML/PDF) |
article
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
Simone Fulda, Wolfgang Wick, Michael Weller and Klaus-Michael Debatin
Nature Medicine 8, 808–815
(August 2002); doi:10.1038/nm735
| Abstract | Full Text (HTML/PDF) |
article
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman, Xiaozhu Huang, Laura L. Koth, Grace H. Chang, Gregory M. Dolganov, Zhou Zhu, Jack A. Elias, Dean Sheppard and David J. Erle
Nature Medicine 8, 885–889
(August 2002); doi:10.1038/nm734
| Abstract | Full Text (HTML/PDF) |
July
letters to nature
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
Daniel E. Michele, Rita Barresi, Motoi Kanagawa, Fumiaki Saito, Ronald D. Cohn, Jakob S. Satz, James Dollar, Ichizo Nishino, Richard I. Kelley, Hannu Somer, Volker Straub, Katherine D. Mathews, Steven A. Moore and Kevin P. Campbell
Nature 418, 417–421
(25 July 2002); doi:10.1038/nature00837
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy
Steven A. Moore, Fumiaki Saito, Jianguo Chen, Daniel E. Michele, Michael D. Henry, Albee Messing, Ronald D. Cohn, Susan E. Ross-Barta, Steve Westra, Roger A. Williamson, Toshinori Hoshi and Kevin P. Campbell
Nature 418, 421–425
(25 July 2002); doi:10.1038/nature00838
| First Paragraph | Full Text (HTML/PDF) |
news and views
Neurobiology: Full circle to cobbled brain
M. Elizabeth Ross
Nature 418, 376–377
(25 July 2002); doi:10.1038/418376a
| Full Text (HTML/PDF) |
news and views
Genetics: Inherit the wheeze
Jeffrey M. Drazen and Scott T. Weiss
Nature 418, 383–384
(25 July 2002); doi:10.1038/418383a
| Full Text (HTML/PDF) |
letters to nature
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Paul Van Eerdewegh, Randall D. Little, Josée Dupuis, Richard G. Del Mastro, Kathy Falls, Jason Simon, Dana Torrey, Sunil Pandit, Joyce McKenny, Karen Braunschweiger, Alison Walsh, Ziying Liu, Brooke Hayward, Colleen Folz, Susan P. Manning, Alicia Bawa, Lisa Saracino, Michelle Thackston, Youssef Benchekroun, Neva Capparell, Mei Wang, Ron Adair, Yun Feng, JoAnn Dubois, Michael G. FitzGerald, Hui Huang, René Gibson, Kristina M. Allen, Alex Pedan, Melvyn R. Danzig, Shelby P. Umland, Robert W. Egan, Francis M. Cuss, Steuart Rorke, Joanne B. Clough, John W. Holloway, Stephen T. Holgate and Tim P. Keith
Nature 418, 426–430
(25 July 2002); doi:10.1038/nature00878
| First Paragraph | Full Text (HTML/PDF) |
insight: review article
Emerging clinical applications of RNA
Bruce A. Sullenger and Eli Gilboa
Nature 418, 252–258
(11 July 2002); doi:10.1038/418252a
| Summary | Full Text (HTML/PDF) |
article
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
Jong-Hoon Kim, Jonathan M. Auerbach, José A. Rodríguez-Gómez, Iván Velasco, Denise Gavin, Nadya Lumelsky, Sang-Hun Lee, John Nguyen, Rosario Sánchez-Pernaute, Krys Bankiewicz and Ron McKay
Nature 418, 50–56
(5th July 2002); doi:10.1038/nature00900
| Abstract | Full Text (HTML/PDF) |
news and views
Biomedicine: Stem-cell competition
Stuart H. Orkin and Sean J. Morrison
Nature 418, 25–27
(5th July 2002); doi:10.1038/418025a
| Full Text (HTML/PDF) |
article
Loss of HIF-2a and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
Veerle Compernolle, Koen Brusselmans, Till Acker, Peter Hoet, Marc Tjwa, Heike Beck, Stéphane Plaisance, Yuval Dor, Eli Keshet, Florea Lupu, Benoit Nemery, Mieke Dewerchin, Paul Van Veldhoven, Karl Plate, Lieve Moons, Désiré Collen and Peter Carmeliet
Nature Medicine 8, 702–710
(July 2002); doi:10.1038/nm721
| Abstract | Full Text (HTML/PDF) |
news and views
Efp: A ring of independence?
Grzegorz Nalepa and J. Wade Harper
Nature Medicine 8, 661–662
(July 2002); doi:10.1038/nm0702-661
| Full Text (HTML/PDF) |
review article
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
Renaud Capdeville, Elisabeth Buchdunger, Juerg Zimmermann and Alex Matter
Nature Reviews Drug Discovery 1, 493–502
(July 2002); doi:10.1038/nrd839
| Abstract | Full Text (HTML/PDF) |
review article
Nucleic-acid therapeutics: basic principles and recent applications
Joanna B. Opalinska and Alan M. Gewirtz
Nature Reviews Drug Discovery 1, 503–514
(July 2002); doi:10.1038/nrd837
| Abstract | Full Text (HTML/PDF) |
June
article
Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Takanori Teshima, Rainer Ordemann, Pavan Reddy, Svetlana Gagin, Chen Liu, Kenneth R. Cooke and James L. M. Ferrara
Nature Medicine 8, 575–581
(June 2002); doi:10.1038/nm0602-575
| Abstract | Full Text (HTML/PDF) |
commentary
Targeting the endocannabinoid system in cancer therapy: A call for further research
Maurizio Bifulco and Vincenzo Di Marzo
Nature Medicine 8, 547–550
(June 2002); doi:10.1038/nm0602-547
| Full Text (HTML/PDF) |
article
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Michael A. Crackower, Renu Sarao, Gavin Y. Oudit, Chana Yagil, Ivona Kozieradzki, Sam E. Scanga, Antonio J. Oliveira-dos-Santos, Joan da Costa, Liyong Zhang, York Pei, James Scholey, Carlos M. Ferrario, Armen S. Manoukian, Mark C. Chappell, Peter H. Backx, Yoram Yagil and Josef M. Penninger
Nature 417, 822–828
(20 June 2002); doi:10.1038/nature00786
| Abstract | Full Text (HTML/PDF) |
letter to nature
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
Manolis Pasparakis, Gilles Courtois, Martin Hafner, Marc Schmidt-Supprian, Arianna Nenci, Atiye Toksoy, Monika Krampert, Matthias Goebeler, Reinhard Gillitzer, Alain Israel, Thomas Krieg, Klaus Rajewsky and Ingo Haase
Nature 417, 861–866
(20 June 2002); doi:10.1038/nature00820
| First Paragraph | Full Text (HTML/PDF) |
article
Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells
Claudia Zuany-Amorim, Elzbieta Sawicka, Corinne Manlius, Alain Le Moine, Laura R. Brunet, David M. Kemeny, Gareth Bowen, Graham Rook and Christoph Walker
Nature Medicine 8, 625–629
(June 2002); doi:10.1038/nm0602-625
| Abstract | Full Text (HTML/PDF) |
news and views
Getting balance: Drugs for bipolar disorder share target
Joseph T. Coyle and Husseini K. Manji
Nature Medicine 8, 557–558
(June 2002); doi:10.1038/nm0602-557
| Full Text (HTML/PDF) |
review article
The role of Th1/Th2 polarization in mucosal immunity
Markus F. Neurath, Susetta Finotto and Laurie H. Glimcher
Nature Medicine 8, 567–573
(June 2002); doi:10.1038/nm0602-567
| Abstract | Full Text (HTML/PDF) |
review article
Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses
Cassian Yee and Philip Greenberg
Nature Reviews Cancer 2, 409–419
(June 2002); doi:10.1038/nrc820
| Abstract | Full Text (HTML/PDF) |
article
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
Helmut Butzkueven, Jian-Guo Zhang, Merja Soilu-Hanninen, Hubertus Hochrein, Fiona Chionh, Kylie A. Shipham, Ben Emery, Ann M. Turnley, Steven Petratos, Matthias Ernst, Perry F. Bartlett and Trevor J. Kilpatrick
Nature Medicine 8, 613–619
(June 2002); doi:10.1038/nm0602-613
| Abstract | Full Text (HTML/PDF) |
article
CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation
Ralf A. Linker, Mathias Mäurer, Stefanie Gaupp, Rudolf Martini, Bettina Holtmann, Ralf Giess, Peter Rieckmann, Hans Lassmann, Klaus V. Toyka, Michael Sendtner and Ralf Gold
Nature Medicine 8, 620–624
(June 2002); doi:10.1038/nm0602-620
| Abstract | Full Text (HTML/PDF) |
review article
New treatments for COPD
Peter J. Barnes
Nature Reviews Drug Discovery 1, 437–446
(June 2002); doi:10.1038/nrd820
| Abstract | Full Text (HTML/PDF) |
review article
Angiogenesis modulation in cancer research: novel clinical approaches
Massimo Cristofanilli, Chusilp Charnsangavej & Gabriel N. Hortobagyi
Nature Reviews Drug Discovery 1, 415–426
(June 2002); doi:10.1038/nrd819
| Abstract | Full Text (HTML/PDF) |
May
letters to nature
A common mechanism of action for three mood-stabilizing drugs
Robin S. B. Williams, Lili Cheng, Anne W. Mudge and Adrian J. Harwood
Nature 417, 292–295
(May 2002); doi:10.1038/417292a
| First Paragraph | Full Text (HTML/PDF) |
article
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
M. B. Pepys, J. Herbert, W. L. Hutchinson, G. A. Tennent, H. J. Lachmann, J. R. Gallimore, L. B. Lovat, T. Bartfai, A. Alanine, C. Hertel, T. Hoffmann, R. Jakob-Roetne, R. D. Norcross, J. A. Kemp, K. Yamamura, M. Suzuki, G. W. Taylor, S. Murray, D. Thompson, A. Purvis, S. Kolstoe, S. P. Wood and P. N. Hawkins
Nature 417, 254–259
(May 2002); doi:10.1038/417254a
| Summary | Full Text (HTML/PDF) |
news and views
Amyloid diseases: Small drugs lead the attack
Leslie Iversen
Nature 417, 231–233
(May 2002); doi:10.1038/417231a
| Full Text (HTML/PDF) |
article
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
Christopher Lock, Guy Hermans, Rosetta Pedotti, Andrea Brendolan, Eric Schadt, Hideki Garren, Annette Langer-Gould, Samuel Strober, Barbara Cannella, John Allard, Paul Klonowski, Angela Austin, Nagin Lad, Naftali Kaminski, Stephen J. Galli, Jorge R. Oksenberg, Cedric S. Raine, Renu Heller and Lawrence Steinman
Nature Medicine 8, 500–508
(May 2002); doi:10.1038/nm0502-500
| Abstract | Full Text (HTML/PDF) |
news and views
An array of possibilities for multiple sclerosis
Stephen M. Tompkins and Stephen D. Miller
Nature Medicine 8, 451–453
(May 2002); doi:10.1038/nm0502-451
| Full Text (HTML/PDF) |
perspectives
Timeline: Development of anti-TNF therapy for rheumatoid arthritis
Marc Feldmann
Nature Reviews Immunology 2, 364–371
(May 2002); doi:10.1038/nri802
| Abstract | Full Text (HTML/PDF) |
news and views
Nicotinic receptors: Addiction's smoking gun?
Ann E. Kelley
Nature Medicine 8, 447–449
(May 2002); doi:10.1038/nm0502-447
| Full Text (HTML/PDF) |
review article
Papillomaviruses and cancer: from basic studies to clinical application
Harald zur Hausen
Nature Reviews Cancer 2, 342–350
(May 2002); doi:10.1038/nrc798
| Abstract | Full Text (HTML/PDF) |
review article
THE GDNF FAMILY: SIGNALLING, BIOLOGICAL FUNCTIONS AND THERAPEUTIC VALUE
Matti S. Airaksinen, Mart Saarma and
Nature Reviews Neuroscience 3, 383–394
(May 2002); doi:10.1038/nrn812
| Abstract | Full Text (HTML/PDF) |
review article
CHILDHOOD ABSENCE EPILEPSY: GENES, CHANNELS, NEURONS AND NETWORKS
Vincenzo Crunelli and Nathalie Leresche
Nature Reviews Neuroscience 3, 371–382
(May 2002); doi:10.1038/nrn811
| Abstract | Full Text (HTML/PDF) |
review article
POTENTIAL CARDIOPROTECTIVE ACTIONS OF NO-RELEASING ASPIRIN
John L. Wallace, Louis J. Ignarro and Stefano Fiorucci
Nature Reviews Drug Discovery 1, 375–382
(May 2002); doi:10.1038/nrd794
| Abstract | Full Text (HTML/PDF) |
review article
NEW THERAPEUTICS THAT MODULATE CHEMOKINE NETWORKS
Matthias K. Schwarz and Timothy N. C. Wells
Nature Reviews Drug Discovery 1, 347–358
(May 2002); doi:10.1038/nrd795
| Abstract | Full Text (HTML/PDF) |
April
review article
PXR, CAR AND DRUG METABOLISM
Timothy M. Willson and Steven A. Kliewer
Nature Reviews Drug Discovery 1, 259–266
(April 2002); doi:10.1038/nrd753
| Abstract | Full Text (HTML/PDF) |
review article
OBESITY THERAPY: ALTERING THE ENERGY INTAKE-AND-EXPENDITURE BALANCE SHEET
Vivion E. F. Crowley, Giles S. H. Yeo and Stephen O'Rahilly
Nature Reviews Drug Discovery 1, 276–286
(April 2002); doi:10.1038/nrd770
| Abstract | Full Text (HTML/PDF) |
perspectives
TIMELINE: Protein kinases — the major drug targets of the twenty-first century?
Philip Cohen
Nature Reviews Drug Discovery 1, 309–315
(April 2002); doi:10.1038/nrd773
| Abstract | Full Text (HTML/PDF) |
review article
VACCINES: SPINNING MOLECULAR IMMUNOLOGY INTO SUCCESSFUL IMMUNOTHERAPY
Drew M. Pardoll
Nature Reviews Immunology 2, 227–238
(April 2002); doi:10.1038/nri774
| Abstract | Full Text (HTML/PDF) |
review article
CYTOLYTIC PATHWAYS IN HAEMATOPOIETIC STEM-CELL TRANSPLANTATION
Marcel R. M. van den Brink and Steven J. Burakoff
Nature Reviews Immunology 2, 273–281
(April 2002); doi:10.1038/nri775
| Abstract | Full Text (HTML/PDF) |
review article
g-SECRETASE, NOTCH, Ab AND ALZHEIMER'S DISEASE: WHERE DO THE PRESENILINS FIT IN?
Sangram S. Sisodia and Peter H. St George-Hyslop
Nature Reviews Neuroscience 3, 281–290
(April 2002); doi:10.1038/nrn785
| Abstract | Full Text (HTML/PDF) |
review article
NEW CONCEPTS IN THE IMMUNOPATHOGENESIS OF MULTIPLE SCLEROSIS
Bernhard Hemmer, Juan J. Archelos and Hans-Peter Hartung
Nature Reviews Neuroscience 3, 291–301
(April 2002); doi:10.1038/nrn784
| Abstract | Full Text (HTML/PDF) |
news and views
A double-edged sword
Valerie Ferrier
Nature Cell Biology 4, E79
(April 2002); doi:10.1038/ncb0402-e79
| Full Text (HTML/PDF) |
news and views
Block the FAS, lose the fat
Charles V. Mobbs and Hideo Makimura
Nature Medicine 8, 335–336
(April 2002); doi:10.1038/nm0402-335
| Full Text (HTML/PDF) |
article
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness
Norikatsu Mizumoto, Tadashi Kumamoto, Simon C. Robson, Jean Sévigny, Hiroyuki Matsue, Keiichi Enjyoji and Akira Takashima
Nature Medicine 8, 358–365
(April 2002); doi:10.1038/nm0402-358
| Abstract | Full Text (HTML/PDF) |
news and views
The skinny on CD39 in immunity and inflammation
Richard D. Granstein
Nature Medicine 8, 336–338
(April 2002); doi:10.1038/nm0402-336
| Full Text (HTML/PDF) |
news and views
Not just research tools—proteasome inhibitors offer therapeutic promise
Alfred L. Goldberg and Kenneth Rock
Nature Medicine 8, 338–340
(April 2002); doi:10.1038/nm0402-338
| Full Text (HTML/PDF) |
March
review article
GETTING UNDER THE SKIN OF EPIDERMAL MORPHOGENESIS
Elaine Fuchs and Srikala Raghavan
Nature Reviews Genetics 3, 199–209
(March 2002); doi:10.1038/nrg758
| Abstract | Full Text (HTML/PDF) |
review article
REGULATORS OF G-PROTEIN SIGNALLING AS NEW CENTRAL NERVOUS SYSTEM DRUG TARGETS
Richard R. Neubig and David P. Siderovski
Nature Reviews Drug Discovery 1, 187–197
(March 2002); doi:10.1038/nrd747
| Abstract | Full Text (HTML/PDF) |
review article
ALLOSTERIC BINDING SITES ON CELL-SURFACE RECEPTORS: NOVEL TARGETS FOR DRUG DISCOVERY
Arthur Christopoulos
Nature Reviews Drug Discovery 1, 198–210
(March 2002); doi:10.1038/nrd746
| Abstract | Full Text (HTML/PDF) |
perspectives
INNOVATION: Indirect monitoring of lung inflammation
Paolo Montuschi
Nature Reviews Drug Discovery 1, 238–242
(March 2002); doi:10.1038/nrd751
| Abstract | Full Text (HTML/PDF) |
news and views
Neurobiology: A cool ion channel
Charles S. Zuker
Nature 416, 27–28
(March 2002); doi:10.1038/416027a
| Full Text (HTML/PDF) |
article
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
David D. McKemy, Werner M. Neuhausser and David Julius
Nature 416, 52–59
(March 2002); doi:10.1038/nature719
| First Paragraph | Full Text (HTML/PDF) |
February
review article
EFFICACY AT G-PROTEIN-COUPLED RECEPTORS
Terry Kenakin
Nature Reviews Drug Discovery 1, 103–110
(February 2002); doi:10.1038/nrd722
| Abstract | Full Text (HTML/PDF) |
review article
APOPTOSIS-BASED THERAPIES
John C. Reed
Nature Reviews Drug Discovery 1, 111–121
(February 2002); doi:10.1038/nrd726
| Abstract | Full Text (HTML/PDF) |
review article
ENDOCRINE-RESPONSIVE BREAST CANCER AND STRATEGIES FOR COMBATING RESISTANCE
Simak Ali and R. Charles Coombes
Nature Reviews Cancer 2, 101–112
(February 2002); doi:10.1038/nrc721
| Abstract | Full Text (HTML/PDF) |
review article
RHO-GTPASES AND CANCER
Erik Sahai and Christopher J. Marshall
Nature Reviews Cancer 2, 133–142
(February 2002); doi:10.1038/nrc725
| Abstract | Full Text (HTML/PDF) |
review article
CHEMOKINE RECEPTORS: MULTIFACETED THERAPEUTIC TARGETS
Amanda E. I. Proudfoot
Nature Reviews Immunology 2, 106–115
(February 2002); doi:10.1038/nri722
| Abstract | Full Text (HTML/PDF) |
news and views
An essential link to mammary cancer?
Sibylle Tonko-Geymayer and Wolfgang Doppler
Nature Medicine 8, 108–110
(February 2002); doi:10.1038/nm0202-108
| Full Text (HTML/PDF) |
news and views
Hip, Hip, Hippi!
Valerie Ferrier
Nature Cell Biology 4, E30
(February 2002); doi:10.1038/ncb0202-e30
| Full Text (HTML/PDF) |
article
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
François G. Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R. Leavitt, Martina Metzler, Abigail S. Hackam, John Tam, John P. Vaillancourt, Vicky Houtzager, Dita M. Rasper, Sophie Roy, Michael R. Hayden and Donald W. Nicholson
Nature Cell Biology 4, 95–105
(February 2002); doi:10.1038/ncb735
| Abstract | Full Text (HTML/PDF) |
news and views
Huntington's disease: Accomplices to neuronal death
Mark P. Mattson
Nature 415, 377–379
(January 2002); doi:10.1038/415377a
| Full Text (HTML/PDF) |
article
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda and Shizuo Akira
Nature Immunology 3, 196–200
(February 2002); doi:10.1038/ni758
| Abstract | Full Text (HTML/PDF) |
news and views
New avenues for anti-inflammatory therapy
Charles R. Mackay
Nature Medicine 8, 117–118
(February 2002); doi:10.1038/nm0202-117
| Full Text (HTML/PDF) |
article
CCL27-CCR10 interactions regulate T cell-mediated skin inflammation
Bernard Homey, Harri Alenius, Anja Müller, Hortensia Soto, Edward P. Bowman, Wei Yuan, Leslie McEvoy, Antti I. Lauerma, Till Assmann, Erich Bünemann, Maili Lehto, Henrik Wolff, David Yen, Heather Marxhausen, Wayne To, Jonathon Sedgwick, Thomas Ruzicka, Percy Lehmann and Albert Zlotnik
Nature Medicine 8, 157–165
(February 2002); doi:10.1038/nm0202-157
| Abstract | Full Text (HTML/PDF) |
article
Steps toward mapping the human vasculature by phage display
Wadih Arap, Mikhail G. Kolonin, Martin Trepel, Johanna Lahdenranta, Marina Cardó-Vila, Ricardo J. Giordano, Paul J. Mintz, Peter U. Ardelt, Virginia J. Yao, Claudia I. Vidal, Limor Chen, Anne Flamm, Heli Valtanen, Lisa M. Weavind, Marshall E. Hicks, Raphael E. Pollock, Gregory H. Botz, Corazon D. Bucana, Erkki Koivunen, Dolores Cahill, Patricia Troncoso, Keith A. Baggerly, Rebecca D. Pentz, Kim-Anh Do, Christopher J. Logothetis and Renata Pasqualini
Nature Medicine 8, 121–127
(February 2002); doi:10.1038/nm0202-121
| Abstract | Full Text (HTML/PDF) |
insight
The pathogenic basis of malaria
Louis H. Miller, Dror I. Baruch, Kevin Marsh and Ogobara K. Doumbo
Nature 415, 673–679
(February 2002); doi:10.1038/415673a
| Summary | Full Text (HTML/PDF) |
January
review article
HYPOXIA — A KEY REGULATORY FACTOR IN TUMOUR GROWTH
Adrian L. Harris
Nature Reviews Cancer 2, 38–47
(January 2002); doi:10.1038/nrc704
| Abstract | Full Text (HTML/PDF) |
review article
EMERGING IMMUNE TARGETS FOR THE THERAPY OF ALLERGIC ASTHMA
David B. Corry
Nature Reviews Drug Discovery 1, 55–64
(January 2002); doi:10.1038/nrd702
| Abstract | Full Text (HTML/PDF) |
article
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
Masanori Asakura, Masafumi Kitakaze, Seiji Takashima, Yulin Liao, Fuminobu Ishikura, Tsuyoshi Yoshinaka, Hiroshi Ohmoto, Koichi Node, Kohichiro Yoshino, Hiroshi Ishiguro, Hiroshi Asanuma, Shoji Sanada, Yasushi Matsumura, Hiroshi Takeda, Shintaro Beppu, Michihiko Tada, Masatsugu Hori and Shigeki Higashiyama
Nature Medicine 8, 35–40
(January 2002); doi:10.1038/nm0102-35
| Abstract | Full Text (HTML/PDF) |
news and views
Shedding growth factors in cardiac hypertrophy
James K. Liao
Nature Medicine 8, 20–21
(January 2002); doi:10.1038/nm0102-20
| Full Text (HTML/PDF) |
news and views
Microbiology: Group effort in toxin synthesis
Gary M. Dunny
Nature 415, 33–34
(January 2002); doi:10.1038/415033a
| Full Text (HTML/PDF) |
|
