review article Neuropeptide gene polymorphisms and human behavioural disorders
Akio Inui Nature Reviews Drug Discovery2, 986–998
(December 2003); doi:10.1038/nrd1252
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Taking our breath away: dendritic cells in the pathogenesis of asthma
Bart N. Lambrecht and Hamida Hammad Nature Reviews Immunology3, 994–1003
(December 2003); doi:10.1038/nri1249
| Abstract | Full Text (HTML / PDF) |
review article The 14-3-3 cancer connection
Heiko Hermeking Nature Reviews Cancer3, 931–943
(December 2003); doi:10.1038/nrc1230
| Abstract | Full Text (HTML / PDF) |
review article GLIA: A novel drug discovery target for clinical pain
Linda R. Watkins and Steven F. Maier Nature Reviews Drug Discovery2, 973–985
(December 2003); doi:10.1038/nrd1251
| Abstract | Full Text (HTML / PDF) |
review article Opportunities in somatostatin research: biological, chemical and therapeutic aspects
Gisbert Weckbecker, Ian Lewis, Rainer Albert, Herbert A. Schmid, Daniel Hoyer and Christian Bruns Nature Reviews Drug Discovery2, 999–1017
(December 2003); doi:10.1038/nrd1255
| Abstract | Full Text (HTML / PDF) |
news and views JAKing up immunosuppression
Megan Sykes Nature Medicine9, 1458–1459
(December 2003); doi:10.1038/nm1203-1458
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review article Cancer pharmacogenetics: polymorphisms, pathways and beyond
Cornelia M. Ulrich, Kim Robien and Howard L. McLeod Nature Reviews Cancer3, 912–920
(December 2003); doi:10.1038/nrc1233
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
Saïd M. Sebti and Channing J. Der Nature Reviews Cancer3, 945–951
(December 2003); doi:10.1038/nrc1234
| Abstract | Full Text (HTML / PDF) |
review article Tissue microarrays in drug discovery
Guido Sauter, Ronald Simon and Kenneth Hillan Nature Reviews Drug Discovery2, 962–972
(December 2003); doi:10.1038/nrd1254
| Abstract | Full Text (HTML / PDF) |
November
letters to nature Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Takashi Nomura, Tomoyuki Tagami, Sayuri Yamazaki, Toshiko Sakihama, Takaji Matsutani, Izumi Negishi, Syuichi Nakatsuru & Shimon Sakaguchi Nature426, 454–460
(27 November 2003); doi:10.1038/nature02119
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article Ex vivo identification, isolation and analysis of tumor-cytolytic T cells
Valerie Rubio, Tor B Stuge, Naileshni Singh, Michael R Betts, Jeffrey S Weber, Mario Roederer and Peter P Lee Nature Medicine9, 1377–1382
(November 2003); doi:10.1038/nm942
| Abstract | Full Text (HTML/PDF) |
letter PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia
Rose Ann Padua, Jerome Larghero, Marie Robin, Carol le Pogam, Marie-Helene Schlageter, Sacha Muszlak, Jan Fric, Robert West, Philippe Rousselot, Thi Hai Phan, Liesbeth Mudde, Helene Teisserenc, Antoine F Carpentier, Scott Kogan, Laurent Degos, Marika Pla, J Michael Bishop, Freda Stevenson, Dominique Charron and Christine Chomienne Nature Medicine9, 1413–1417
(November 2003); doi:10.1038/nm949
| First Paragraph | Full Text (HTML/PDF) |
news and views Cancer vaccine targets leukemia
John Donnelly Nature Medicine9, 1354–1356
(November 2003); doi:10.1038/nm1103-1354
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brief communication Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
David Engblom, Sipra Saha, Linda Engström, Marie Westman, Laurent P Audoly, Per-Johan Jakobsson and Anders Blomqvist Nature Neuroscience6, 1137–1138
(November 2003); doi:10.1038/nn1137
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article HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation
Mariana Marin, Kristine M. Rose, Susan L. Kozak and David Kabat Nature Medicine9, 1398–1403
(November 2003); doi:10.1038/nm946
| Abstract | Full Text (HTML/PDF) |
letter The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
Ann M. Sheehy, Nathan C. Gaddis and Michael H. Malim Nature Medicine9, 1404–1407
(November 2003); doi:10.1038/nm945
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review article Aromatase inhibitors for breast cancer: lessons from the laboratory
Stephen R.D. Johnston and Mitch Dowsett Nature Reviews Cancer3, 821–831
(November 2003); doi:10.1038/nrc1211
| Abstract | Full Text (HTML / PDF) |
letter Positional cloning of a novel gene influencing asthma from Chromosome 2q14
Maxine Allen, Andrea Heinzmann, Emiko Noguchi, Gonçalo Abecasis, John Broxholme, Chris P. Ponting, Sumit Bhattacharyya, Jon Tinsley, Youming Zhang, Richard Holt, E. Yvonne Jones, Nick Lench, Alisoun Carey, Helene Jones, Nicholas J. Dickens, Claire Dimon, Rosie Nicholls, Crystal Baker, Luzheng Xue, Elizabeth Townsend, Michael Kabesch, Stephan K. Weiland, David Carr, Erika von Mutius, Ian M. Adcock, Peter J. Barnes, G. Mark Lathrop, Mark Edwards, Miriam F. Moffatt and William O. C. M. Cookson Nature Genetics35, 258–263
(November 2003); doi:10.1038/ng1256
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article Targeting cytokines to inflammation sites
Gill Adams, Sandrine Vessillier, Hanna Dreja and Yuti Chernajovsky Nature Biotechnology21, 1314–1320
(November 2003); doi:10.1038/nbt888
| Abstract | Full Text (HTML/PDF) |
news and views Engineering better cytokines
Lawrence Steinman Nature Biotechnology21, 1293–1294
(November 2003); doi:10.1038/nbt1103-1293
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review article Targeting the Nogo Receptor to Treat Central Nervous System Injuries
Daniel H. S. Lee, Stephen M. Strittmatter and Dinah W. Y. Sah Nature Reviews Drug Discovery2, 872–879
(November 2003); doi:10.1038/nrd1228
| Abstract | Full Text (HTML / PDF) |
article An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Jayakrishna Ambati, Akshay Anand, Stefan Fernandez, Eiji Sakurai, Bert C Lynn, William A Kuziel, Barrett J Rollins and Balamurali K Ambati Nature Medicine9, 1390–1397
(November 2003); doi:10.1038/nm950
| Abstract | Full Text (HTML/PDF) |
news and views Macrophages eyed in macular degeneration
J V Forrester Nature Medicine9, 1350–1351
(November 2003); doi:10.1038/nm1103-1350
| Full Text (HTML/PDF) |
review article The molecular logic of endocannabinoid signalling
Daniele Piomelli Nature Reviews Neuroscience4, 873–884
(November 2003); doi:10.1038/nrn1247
| Abstract | Full Text (HTML / PDF) |
news and views Setting fat on fire
Robert Walczak and Peter Tontonoz Nature Medicine9, 1348–1349
(November 2003); doi:10.1038/nm1103-1348
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October
article Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
Nicola J Monk, Roseanna E G Hargreaves, James E Marsh, Conrad A Farrar, Steven H Sacks, Maggie Millrain, Elizabeth Simpson, Julian Dyson and Stipo Jurcevic Nature Medicine9, 1275–1280
(October 2003); doi:10.1038/nm931
| Abstract | Full Text (HTML/PDF) |
news and views The new immunosuppression: just kill the T cell
Herman Waldmann Nature Medicine9, 1259–1260
(October 2003); doi:10.1038/nm1003-1259
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article Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses
Simona Stäger, James Alexander, Alun C Kirby, Marina Botto, Nico Van Rooijen, Deborah F Smith, Frank Brombacher and Paul M Kaye Nature Medicine9, 1287–1292
(October 2003); doi:10.1038/nm933
| Abstract | Full Text (HTML/PDF) |
letter Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
Vincent H Gattone II, Xiaofang Wang, Peter C Harris and Vicente E Torres Nature Medicine9, 1323–1326
(October 2003); doi:10.1038/nm935
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review article Cannabinoids: potential anticancer agents
Manuel Guzmán Nature Reviews Cancer3, 745–755
(October 2003); doi:10.1038/nrc1188
| Abstract | Full Text (HTML / PDF) |
review article Cancer chemoprevention with dietary phytochemicals
Young-Joon Surh Nature Reviews Cancer3, 768–780
(October 2003); doi:10.1038/nrc1189
| Abstract | Full Text (HTML / PDF) |
review article HIF-1 as a target for drug development
Amato Giaccia, Bronwyn G. Siim and Randall S. Johnson Nature Reviews Drug Discovery2, 803–811
(October 2003); doi:10.1038/nrd1199
| Abstract | Full Text (HTML / PDF) |
article β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure
Jeanne Mialet Perez, Deborah A Rathz, Natalia N Petrashevskaya, Harvey S Hahn, Lynne E Wagoner, Arnold Schwartz, Gerald W Dorn II and Stephen B Liggett Nature Medicine9, 1300–1305
(October 2003); doi:10.1038/nm930
| Abstract | Full Text (HTML/PDF) |
news and views β-receptor polymorphisms: heart failure's crystal ball
David A Kass Nature Medicine9, 1260–1262
(October 2003); doi:10.1038/nm1003-1260
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review article Mechanisms of sarcoma development
Lee J. Helman and Paul Meltzer Nature Reviews Cancer3, 685–694
(September 2003); doi:10.1038/nrc1168
| Abstract | Full Text (HTML / PDF) |
news and views Neurobiology: Double trouble for neurons
Mark E. Fortini Nature425, 565–566
(09 October 2003); doi:10.1038/425565a
| Full Text (HTML / PDF) |
article Identification of PDGFR as a receptor for AAV-5 transduction
Giovanni Di Pasquale, Beverly L. Davidson, Colleen S. Stein, Inês Martins, Dominic Scudiero, Anne Monks and John A. Chiorini Nature Medicine9, 1306–1312
(October 2003); doi:10.1038/nm929
| Abstract | Full Text (HTML/PDF) |
review article Targeting HIF-1 for cancer therapy
Gregg L. Semenza Nature Reviews Cancer3, 721–732
(October 2003); doi:10.1038/nrc1187
| Abstract | Full Text (HTML / PDF) |
perspectives Innovation: Target discovery
Mark A. Lindsay Nature Reviews Drug Discovery2, 831–838
(October 2003); doi:10.1038/nrd1202
| Abstract | Full Text (HTML / PDF) |
perspectives Timeline: Individuality: the barrier to optimal immunosuppression
Barry D. Kahan Nature Reviews Immunology3, 831–838
(October 2003); doi:10.1038/nri1204
| Abstract | Full Text (HTML / PDF) |
brief communication Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer
H. Rosie Xing, Carlos Cordon-Cardo, Xinzhu Deng, William Tong, Luis Campodonico, Zvi Fuks and Richard Kolesnick Nature Medicine9, 1267–1268
(October 2003); doi:10.1038/nm927
| First Paragraph | Full Text (HTML/PDF) |
article Differential requirement for CD18 in T-helper effector homing
Seung-Hyo Lee, Joseph E. Prince, Muhammad Rais, Farrah Kheradmand, Felix Shardonofsky, Huifang Lu, Arthur L. Beaudet, C. Wayne Smith, Lynn Soong and David B. Corry Nature Medicine9, 1281–1286
(October 2003); doi:10.1038/nm932
| Abstract | Full Text (HTML/PDF) |
article The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
Solveig Gretarsdottir, Gudmar Thorleifsson, Sigridur Th Reynisdottir, Andrei Manolescu, Sif Jonsdottir, Thorbjörg Jonsdottir, Thorunn Gudmundsdottir, Sigrun M. Bjarnadottir, Olafur B. Einarsson, Herdis M. Gudjonsdottir, Malcolm Hawkins, Gudmundur Gudmundsson, Hrefna Gudmundsdottir, Hjalti Andrason, Asta S. Gudmundsdottir, Matthildur Sigurdardottir, Thomas T. Chou, Joseph Nahmias, Shyamali Goss, Sigurlaug Sveinbjörnsdottir, Einar M. Valdimarsson, Finnbogi Jakobsson, Uggi Agnarsson, Vilmundur Gudnason, Gudmundur Thorgeirsson, Jurgen Fingerle, Mark Gurney, Daniel Gudbjartsson, Michael L. Frigge, Augustine Kong, Kari Stefansson and Jeffrey R. Gulcher Nature Genetics35, 131–138
(October 2003); doi:10.1038/ng1245
| Abstract | Full Text (HTML/PDF) |
news and views Genetics of common polygenic stroke
Anna F. Dominiczak and Martin W. McBride Nature Genetics35, 116–117
(October 2003); doi:10.1038/ng1003-116
| Full Text (HTML/PDF) |
September
letters to nature A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
Adeela Kamal, Lia Thao, John Sensintaffar, Lin Zhang, Marcus F. Boehm, Lawrence C. Fritz and Francis J. Burrows Nature425, 407–410
(25 September 2003); doi:10.1038/nature01913
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news and views Cancer: The rules of attraction
Len Neckers and Yong-Sok Lee Nature425, 357–359
(25 September 2003); doi:10.1038/425357a
| Full Text (HTML / PDF) |
review article Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
Robert A. Seder and Rafi Ahmed Nature Immunology4, 835–842
(September 2003); doi:10.1038/ni969
| Abstract | Full Text (HTML/PDF) |
review article The regulation of immunoglobulin E class-switch recombination
Raif S. Geha, Haifa H. Jabara and Scott R. Brodeur Nature Reviews Immunology3, 721–732
(September 2003); doi:10.1038/nri1181
| Abstract | Full Text (HTML / PDF) |
article A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
Tiziana Borsello, Peter G. H. Clarke, Lorenz Hirt, Alessandro Vercelli, Mariaelena Repici, Daniel F. Schorderet, Julien Bogousslavsky and Christophe Bonny Nature Medicine9, 1180–1186
(September 2003); doi:10.1038/nm911
| Abstract | Full Text (HTML/PDF) |
review article Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Marie T. Filbin Nature Reviews Neuroscience4, 703–713
(September 2003); doi:10.1038/nrn1195
| Abstract | Full Text (HTML / PDF) |
research article The application of bone morphogenetic proteins to dental tissue engineering
Misako Nakashima and A. Hari Reddi Nature Biotechnology21, 1025–1032
(September 2003); doi:10.1038/nbt864
| Abstract | Full Text (HTML/PDF) |
review article p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
Sanjay Kumar, Jeffrey Boehm and John C. Lee Nature Reviews Drug Discovery2, 717–726
(September 2003); doi:10.1038/nrd1177
| Abstract | Full Text (HTML / PDF) |
review article Anti-TNF-α therapies: the next generation
Michael A. Palladino, Frances Rena Bahjat, Emmanuel A. Theodorakis and Lyle L. Moldawer Nature Reviews Drug Discovery2, 736–746
(September 2003); doi:10.1038/nrd1175
| Abstract | Full Text (HTML / PDF) |
letter Activation of the interferon system by short-interfering RNAs
Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman and Bryan R.G. Williams Nature Cell Biology5, 834–839
(September 2003); doi:10.1038/ncb1038
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news and views Small-interfering RNAs in the radar of the interferon system
Eric G. Moss and John M. Taylor Nature Cell Biology5, 771–772
(September 2003); doi:10.1038/ncb0903-771
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article TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
Mériam Belghith, Jeffrey A. Bluestone, Samia Barriot, Jérome Mégret, Jean-François Bach and Lucienne Chatenoud Nature Medicine9, 1202–1208
(September 2003); doi:10.1038/nm924
| Abstract | Full Text (HTML/PDF) |
letters to nature Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
Byung-Je Sung, Kwang Yeon Hwang, Young Ho Jeon, Jae Il Lee, Yong-Seok Heo, Jin Hwan Kim, Jinho Moon, Jung Min Yoon, Young-Lan Hyun, Eunmi Kim, Sung Jin Eum, Sam-Yong Park, Jie-Oh Lee, Tae Gyu Lee, Seonggu Ro and Joong Myung Cho Nature425, 98–102
(04 September 2003); doi:10.1038/nature01914
| First Paragraph | Full Text (HTML / PDF) |
review article The role of α-synuclein in Parkinson's disease: insights from animal models
Eleonora Maries, Biplob Dass, Timothy J. Collier, Jeffrey H. Kordower and Kathy Steece-Collier Nature Reviews Neuroscience4, 727–738
(September 2003); doi:10.1038/nrn1199
| Abstract | Full Text (HTML / PDF) |
research article Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors
Oliver J. Müller, Felix Kaul, Matthew D. Weitzman, Renata Pasqualini, Wadih Arap, Jürgen A. Kleinschmidt and Martin Trepel Nature Biotechnology21, 1040–1046
(September 2003); doi:10.1038/nbt856
| Abstract | Full Text (HTML/PDF) |
news and views AAV display—homing in on the target
André Lieber Nature Biotechnology21, 1011–1013
(September 2003); doi:10.1038/nbt0903-1011
| Full Text (HTML/PDF) |
August
article Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination
Edgar A. Otto, Bernhard Schermer, Tomoko Obara, John F. O'Toole, Karl S. Hiller, Adelheid M. Mueller, Rainer G. Ruf, Julia Hoefele, Frank Beekmann, Daniel Landau, John W. Foreman, Judith A. Goodship, Tom Strachan, Andreas Kispert, Matthias T. Wolf, Marie F. Gagnadoux, Hubert Nivet, Corinne Antignac, Gerd Walz, Iain A. Drummond, Thomas Benzing and Friedhelm Hildebrandt Nature Genetics34, 413–420
(August 2003); doi:10.1038/ng1217
| Abstract | Full Text (HTML/PDF) |
news and views From cilia to cyst
Terry Watnick and Gregory Germino Nature Genetics34, 355–356
(August 2003); doi:10.1038/ng0803-355
| Full Text (HTML/PDF) |
letter Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion
Rebecca P. Haberman, R. Jude Samulski and Thomas J. McCown Nature Medicine9, 1076–1080
(August 2003); doi:10.1038/nm901
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news and views Seizing hold of seizures
Gregory L. Holmes and Yezekiel Ben-Ari Nature Medicine9, 994–996
(August 2003); doi:10.1038/nm0803-994
| Full Text (HTML/PDF) |
article VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts, Erik Storkebaum, Masafumi Morimoto, Jurgen Del-Favero, Frederik Desmet, Stefan L. Marklund, Sabine Wyns, Vincent Thijs, Jörgen Andersson, Ingrid van Marion, Ammar Al-Chalabi, Stephanie Bornes, Rhiannon Musson, Valerie Hansen, Lars Beckman, Rolf Adolfsson, Hardev Singh Pall, Hervé Prats, Severine Vermeire, Paul Rutgeerts, Shigehiro Katayama, Takuya Awata, Nigel Leigh, Loïc Lang-Lazdunski, Mieke Dewerchin, Christopher Shaw, Lieve Moons, Robert Vlietinck, Karen E. Morrison, Wim Robberecht, Christine Van Broeckhoven, Désiré Collen, Peter M. Andersen and Peter Carmeliet Nature Genetics34, 383–394
(August 2003); doi:10.1038/ng1211
| Abstract | Full Text (HTML/PDF) |
news and views A new piece of the ALS puzzle
John L. Cleveland Nature Genetics34, 357–358
(August 2003); doi:10.1038/ng0803-357
| Full Text (HTML/PDF) |
review article Caveolae: mining little caves for new cancer targets
Lucy A. Carver and Jan E. Schnitzer Nature Reviews Cancer3, 571–581
(August 2003); doi:10.1038/nrc1146
| Abstract | Full Text (HTML / PDF) |
article Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31
Philomena Mburu, Mirna Mustapha, Anabel Varela, Dominique Weil, Aziz El-Amraoui, Ralph H. Holme, Andreas Rump, Rachel E. Hardisty, Stéphane Blanchard, Roney S. Coimbra, Isabelle Perfettini, Nick Parkinson, Ann-Marie Mallon, Pete Glenister, Mike J. Rogers, Adam J. Paige, Lee Moir, Jo Clay, Andre Rosenthal, Xue Zhong Liu, Gonzalo Blanco, Karen P. Steel, Christine Petit and Steve D. M. Brown Nature Genetics34, 421–428
(August 2003); doi:10.1038/ng1208
| Abstract | Full Text (HTML/PDF) |
review article Attacking pain at its source: new perspectives on opioids
Christoph Stein, Michael Schäfer and Halina Machelska Nature Medicine9, 1003–1008
(August 2003); doi:10.1038/nm908
| Abstract | Full Text (HTML/PDF) |
article Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
Gustav Mattiasson, Mehrdad Shamloo, Gunilla Gido, Kavitha Mathi, Gregor Tomasevic, Saili Yi, Craig H. Warden, Roger F. Castilho, Thorsten Melcher, Mirella Gonzalez-Zulueta, Karoly Nikolich and Tadeusz Wieloch Nature Medicine9, 1062–1068
(August 2003); doi:10.1038/nm903
| Abstract | Full Text (HTML/PDF) |
letters to nature Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
Yih-Cherng Liou , Anyang Sun , Akihide Ryo, Xiao Zhen Zhou, Zhao-Xue Yu, Han-Kuei Huang, Takafumi Uchida, Roderick Bronson, Guoying Bing, Xiaojiang Li, Tony Hunter and Kun Ping Lu Nature424, 556–561
(31 July 2003); doi:10.1038/nature01832
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review article The genetics of malignant melanoma: lessons from mouse and man
Lynda Chin Nature Reviews Cancer3, 559–570
(August 2003); doi:10.1038/nrc1145
| Abstract | Full Text (HTML / PDF) |
July
letters to nature Crystal structure of human cytochrome P450 2C9 with bound warfarin
Pamela A. Williams, Jose Cosme, Alison Ward, Hayley C. Angove, Dijana Matak Vinkovic and Harren Jhoti Nature424, 464–468
(24 July 2003); doi:10.1038/nature01862
| First Paragraph | Full Text (HTML / PDF) |
news and views Rules of conduct for the cystic fibrosis anion channel
Jeffrey J. Wine Nature Medicine9, 827–828
(July 2003); doi:10.1038/nm0703-827
| Full Text (HTML/PDF) |
perspectives Timeline: The bicyclam AMD3100 story
Erik De Clercq Nature Reviews Drug Discovery2, 581–587
(July 2003); doi:10.1038/nrd1134
| Abstract | Full Text (HTML / PDF) |
news and views Angiogenesis inhibitors: motivators of metastasis?
Patricia S Steeg Nature Medicine9, 822–823
(July 2003); doi:10.1038/nm0703-822
| Full Text (HTML/PDF) |
review article The immunological and genetic basis of inflammatory bowel disease
Gerd Bouma and Warren Strober Nature Reviews Immunology3, 521–533
(July 2003); doi:10.1038/nri1132
| Summary | Full Text (HTML / PDF) |
review article Molecular mechanisms of glioma invasiveness: the role of proteases
Jasti S. Rao Nature Reviews Cancer3, 489–501
(July 2003); doi:10.1038/nrc1121
| Summary | Full Text (HTML / PDF) |
review article Targeting JNK for therapeutic benefit: from junk to gold?
Anthony M. Manning and Roger J. Davis Nature Reviews Drug Discovery2, 554–565
(July 2003); doi:10.1038/nrd1132
| Summary | Full Text (HTML / PDF) |
article Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Elisabetta Sabini, Stephan Ort, Christian Monnerjahn, Manfred Konrad and Arnon Lavie Nature Structural Biology10, 513–519
(July 2003); doi:10.1038/nsb942
| Abstract | Full Text (HTML/PDF) |
review article Ovarian cancer: strategies for overcoming resistance to chemotherapy
Roshan Agarwal and Stan B. Kaye Nature Reviews Cancer3, 502–516
(July 2003); doi:10.1038/nrc1123
| Summary | Full Text (HTML / PDF) |
research article A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization
Atique Ahmed, Jill Thompson, Lisa Emiliusen, Stephen Murphy, R Daniel Beauchamp, Kaori Suzuki, Ramon Alemany, Kevin Harrington and Richard G Vile Nature Biotechnology21, 771–777
(July 2003); doi:10.1038/nbt835
| Abstract | Full Text (HTML/PDF) |
news and views Vectorology recapitulates virology—will it capitulate oncology?
Estaurdo Aguilar-Cordova Nature Biotechnology21, 756–757
(July 2003); doi:10.1038/nbt0703-756
| Full Text (HTML/PDF) |
June
article Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
Erwan Bézard, Sandrine Ferry, Ulrich Mach, Holger Stark, Ludovic Leriche, Thomas Boraud, Christian Gross and Pierre Sokoloff Nature Medicine9, 762–767
(June 2003); doi:10.1038/nm875
| Abstract | Full Text (HTML/PDF) |
article Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
Susumu Ishida, Kenji Yamashiro, Tomohiko Usui, Yuichi Kaji, Yuichiro Ogura, Tetsuo Hida, Yoshihito Honda, Yoshihisa Oguchi and Anthony P Adamis Nature Medicine9, 781–788
(June 2003); doi:10.1038/nm877
| Abstract | Full Text (HTML/PDF) |
review article Gene transfer as a tool to induce therapeutic vascular growth
Seppo Ylä-Herttuala and Kari Alitalo Nature Medicine9, 694–701
(June 2003); doi:10.1038/nm0603-694
| Abstract | Full Text (HTML/PDF) |
review article Therapeutic strategies for rheumatoid arthritis
Josef S. Smolen and Günter Steiner Nature Reviews Drug Discovery2, 473–488
(June 2003); doi:10.1038/nrd1109
| Summary | Full Text (HTML / PDF) |
article Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
Kenji Kabashima, Daiji Sakata, Miyako Nagamachi, Yoshiki Miyachi, Kayo Inaba and Shuh Narumiya Nature Medicine9, 744–749
(June 2003); doi:10.1038/nm872
| Abstract | Full Text (HTML/PDF) |
letter Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
Michele De Palma, Mary Anna Venneri, Cristina Roca and Luigi Naldini Nature Medicine9, 789–795
(June 2003); doi:10.1038/nm871
| First Paragraph | Full Text (HTML/PDF) |
letters to nature Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells
M. M. Reddy and P. M. Quinton Nature423, 756–760
(12 June 2003); doi:10.1038/nature01694
| First Paragraph | Full Text (HTML / PDF) |
article A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects
Wolfram E Samlowski, Ryan Petersen, Salvatore Cuzzocrea, Heather Macarthur, Damali Burton, John R McGregor and Daniela Salvemini Nature Medicine9, 750–755
(June 2003); doi:10.1038/nm874
| Abstract | Full Text (HTML/PDF) |
news and views Biological drug duo delivers one-two tumor punch
Jeffrey A Sosman and James W Mier Nature Medicine9, 649–650
(June 2003); doi:10.1038/nm0603-649
| Full Text (HTML/PDF) |
review article When calcium goes wrong: genetic alterations of a ubiquitous signaling route
Rosario Rizzuto and Tullio Pozzan Nature Genetics34, 135–141
(June 2003); doi:10.1038/ng0603-135
| Abstract | Full Text (HTML/PDF) |
review article Ophthalmic drug discovery
Abbot F. Clark and Thomas Yorio Nature Reviews Drug Discovery2, 448–459
(June 2003); doi:10.1038/nrd1106
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review article Predicting therapeutic value in the lead optimization phase of drug discovery
Terry Kenakin Nature Reviews Drug Discovery2, 429–438
(June 2003); doi:10.1038/nrd1110
| Summary | Full Text (HTML / PDF) |
May
article Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
Joseph N. Blattman, Jason M. Grayson, E. John Wherry, Susan M. Kaech, Kendall A. Smith and Rafi Ahmed Nature Medicine9, 540–547
(May 2003); doi:10.1038/nm866
| Abstract | Full Text (HTML/PDF) |
review article Such stuff as dreams are made on: mediator-directed therapy in sepsis
John C. Marshall Nature Reviews Drug Discovery2, 391–405
(May 2003); doi:10.1038/nrd1084
| Summary | Full Text (HTML / PDF) |
review article Pharmacological strategies for muscular dystrophy
Tejvir S. Khurana and Kay E. Davies Nature Reviews Drug Discovery2, 379–390
(May 2003); doi:10.1038/nrd1085
| Summary | Full Text (HTML / PDF) |
perspectives Cancer revoked: oncogenes as therapeutic targets
Dean W. Felsher Nature Reviews Cancer3, 375–379
(May 2003); doi:10.1038/nrc1070
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brief communication Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
Bethan Jones, Emma L. Jones, Stephanie A. Bonney, Hetal N. Patel, Arjen R. Mensenkamp, Sophie Eichenbaum-Voline, Mats Rudling, Urban Myrdal, Grazia Annesi, Sandhia Naik, Nigel Meadows, Aldo Quattrone, Suhail A. Islam, Rossitza P. Naoumova, Bo Angelin, Recaredo Infante, Emile Levy, Claude C. Roy, Paul S. Freemont, James Scott and Carol C. Shoulders Nature Genetics34, 29–31
(May 2003); doi:10.1038/ng1145
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review article Mechanisms, challenges and opportunities in stroke
Eng H. Lo, Turgay Dalkara and Michael A. Moskowitz Nature Reviews Neuroscience4, 399–414
(May 2003); doi:10.1038/nrn1106
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article Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
Stephan R. Krutzik, Maria Teresa Ochoa, Peter A. Sieling, Satoshi Uematsu, Yolanda W. Ng, Annaliza Legaspi, Philip T. Liu, Stewart T. Cole, Paul J. Godowski, Yumi Maeda, Euzenir N. Sarno, Michael V. Norgard, Patrick J. Brennan, Shizuo Akira, Thomas H. Rea and Robert L. Modlin Nature Medicine9, 525–532
(May 2003); doi:10.1038/nm864
| Abstract | Full Text (HTML/PDF) |
article Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Omid Akbari, Philippe Stock, Everett Meyer, Mitchell Kronenberg, Stephane Sidobre, Toshinori Nakayama, Masaru Taniguchi, Michael J. Grusby, Rosemarie H. DeKruyff and Dale T. Umetsu Nature Medicine9, 582–588
(May 2003); doi:10.1038/nm851
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article The two faces of IKK and NF-kB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
Lee-Wei Chen, Laurence Egan, Zhi-Wei Li, Florian R. Greten, Martin F. Kagnoff and Michael Karin Nature Medicine9, 575–581
(May 2003); doi:10.1038/nm849
| Abstract | Full Text (HTML/PDF) |
letter Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
Paolo A. Hernandez, Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman and George A. Diaz Nature Genetics34, 70–74
(May 2003); doi:10.1038/ng1149
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review article Targeting programmed cell death in neurodegenerative diseases
Miquel Vila & Serge Przedborski Nature Reviews Neuroscience4, 365–375
(May 2003); doi:10.1038/nrn1100
| Summary | Full Text (HTML / PDF) |
research article Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
Eric C. Hsu, Belinda Hsi, Masami Hirota-Tsuchihara, Jurgen Ruland, Cathy Iorio, Farida Sarangi, Jingyu Diao, Giovanni Migliaccio, D. Lorne Tyrrell, Norman Kneteman and Christopher D. Richardson Nature Biotechnology21, 519–525
(May 2003); doi:10.1038/nbt817
| Abstract | Full Text (HTML/PDF) |
April
letter A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
Michael K. Cooper, Christopher A. Wassif, Patrycja A. Krakowiak, Jussi Taipale, Ruoyu Gong, Richard I. Kelley, Forbes D. Porter and Philip A. Beachy Nature Genetics33, 508–513
(April 2003); doi:10.1038/ng1134
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review article Issues and progress with protein kinase inhibitors for cancer treatment
Janet Dancey and Edward A. Sausville Nature Reviews Drug Discovery2, 296–313
(April 2003); doi:10.1038/nrd1066
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original paper Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways
Aura S. Kamiguti, Robert J. Harris, Joseph R. Slupsky, Peter K. Baker, John C. Cawley and Mirko Zuzel Oncogene22, 2272–2284
(17 April 2003); doi:10.1038/sj.onc.1206398
| Abstract | Full Text (HTML/PDF) |
letters to nature Subsecond dopamine release promotes cocaine seeking
Paul E. M. Phillips, Garret D. Stuber, Michael L. A. V. Heien, R. Mark Wightman and Regina M. Carelli Nature422, 614–618
(10 April 2003); doi:10.1038/nature01476
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news and views Neurobiology: Dopamine as chicken and egg
David Self Nature422, 573–574
(10 April 2003); doi:10.1038/422573a
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article Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human
Nader Chalhoub, Nadia Benachenhou, Venkatesh Rajapurohitam, Monica Pata, Mathieu Ferron, Annalisa Frattini, Anna Villa and Jean Vacher Nature Medicine9, 399–406
(April 2003); doi:10.1038/nm842
| Abstract | Full Text (HTML/PDF) |
news and views Bad bones, grey hair, one mutation
Brendan F. Boyce Nature Medicine9, 395–396
(April 2003); doi:10.1038/nm0403-395
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letter A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
Mark O'Driscoll, Victor L. Ruiz-Perez, C. Geoffrey Woods, Penny A. Jeggo and Judith A. Goodship Nature Genetics33, 497–501
(April 2003); doi:10.1038/ng1129
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review article Senescence, apoptosis and therapy — cutting the lifelines of cancer
Clemens A. Schmitt Nature Reviews Cancer3, 286–295
(April 2003); doi:10.1038/nrc1044
| Summary | Full Text (HTML / PDF) |
research article Enhancement of therapeutic protein in vivo activities through glycoengineering
Steve Elliott, Tony Lorenzini, Sheilah Asher, Ken Aoki, David Brankow, Lynette Buck, Leigh Busse, David Chang, Janis Fuller, James Grant, Natasha Hernday, Martha Hokum, Sylvia Hu, Andrew Knudten, Nancy Levin, Renee Komorowski, Frank Martin, Rachell Navarro, Timothy Osslund, Gary Rogers, Norma Rogers, Geri Trail and Joan Egrie Nature Biotechnology21, 414–421
(April 2003); doi:10.1038/nbt799
| Abstract | Full Text (HTML/PDF) |
March
article A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma-associated herpesvirus latency
Masahiro Fujimuro, Frederick Y. Wu, Colette apRhys, Henry Kajumbula, David B. Young, Gary S. Hayward and S. Diane Hayward Nature Medicine9, 300–306
(March 2003); doi:10.1038/nm829
| Abstract | Full Text (HTML/PDF) |
news and views Kaposi virus scores cancer coup
Chris Boshoff Nature Medicine9, 261–262
(March 2003); doi:10.1038/nm0303-261
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research article In situ assembly of enzyme inhibitors using extended tethering
Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann, Tinh N. Luong, Robert L. Simmons, Warren L. DeLano, Ingrid C. Choong, Matthew T. Burdett, W. Michael Flanagan, Dennis Lee, Eric M. Gordon and Tom O'Brien Nature Biotechnology21, 308–314
(March 2003); doi:10.1038/nbt786
| Abstract | Full Text (HTML/PDF) |
review article Neuroblastoma: biological insights into a clinical enigma
Garrett M. Brodeur Nature Reviews Cancer3, 203–216
(March 2003); doi:10.1038/nrc1014
| Summary | Full Text (HTML / PDF) |
letter Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Enid R. Neptune, Pamela A. Frischmeyer, Dan E. Arking, Loretha Myers, Tracie E. Bunton, Barbara Gayraud, Francesco Ramirez, Lynn Y. Sakai and Harry C. Dietz Nature Genetics33, 407–411
(March 2003); doi:10.1038/ng1116
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news and views Fibrillin controls TGF-β activation
Vesa Kaartinen and David Warburton Nature Genetics33, 331–332
(March 2003); doi:10.1038/ng0303-331
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letters to nature Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema
David G. Morris, Xiaozhu Huang, Naftali Kaminski, Yanli Wang, Steven D. Shapiro, Gregory Dolganov, Adam Glick and Dean Sheppard Nature422, 169–173
(13 March 2003); doi:10.1038/nature01413
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news and views Medicine: Smoke signals for lung disease
Anita B. Roberts Nature422, 130–131
(13 March 2003); doi:10.1038/422130a
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article The thrombomodulin-protein C system is essential for the maintenance of pregnancy
Berend Isermann, Rashmi Sood, Rafal Pawlinski, Mark Zogg, Shawn Kalloway, Jay L. Degen, Nigel Mackman and Hartmut Weiler Nature Medicine9, 331–337
(March 2003); doi:10.1038/nm825
| Abstract | Full Text (HTML/PDF) |
article Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
Tong Cheng, Dong Liu, John H. Griffin, José A. Fernández, Francis Castellino, Elliot D. Rosen, Kenji Fukudome and Berislav V. Zlokovic Nature Medicine9, 338–342
(March 2003); doi:10.1038/nm826
| Abstract | Full Text (HTML/PDF) |
news and views PAR1 signaling: more good than harm?
Wolfram Ruf Nature Medicine9, 258–260
(March 2003); doi:10.1038/nm0303-258
| Full Text (HTML/PDF) |
review article Dying for a cause: invertebrate genetics takes on human neurodegeneration
Monica Driscoll and Beate Gerstbrein Nature Reviews Genetics4, 181–194
(March 2003); doi:10.1038/nrg1018
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article RNA interference targeting Fas protects mice from fulminant hepatitis
Erwei Song, Sang-Kyung Lee, Jie Wang, Nedim Ince, Nengtai Ouyang, Jun Min, Jisheng Chen, Premlata Shankar and Judy Lieberman Nature Medicine9, 347–351
(March 2003); doi:10.1038/nm828
| Abstract | Full Text (HTML/PDF) |
news and views siRNAs knock down hepatitis
Phillip D. Zamore and Neil Aronin Nature Medicine9, 266–267
(March 2003); doi:10.1038/nm0303-266
| Full Text (HTML/PDF) |
February
review article CD3-specific antibody-induced active tolerance: from bench to bedside
Lucienne Chatenoud Nature Reviews Immunology3, 123–132
(February 2003); doi:10.1038/nri1000
| Summary | Full Text (HTML / PDF) |
review article The role of p53 in determining sensitivity to radiotherapy
Andrei V. Gudkov and Elena A. Komarova Nature Reviews Cancer3, 117–129
(February 2003); doi:10.1038/nrc992
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review article Inhibiting the p53-MDM2 interaction: an important target for cancer therapy
Patrick Chène Nature Reviews Cancer3, 102–109
(February 2003); doi:10.1038/nrc991
| Summary | Full Text (HTML / PDF) |
perspectives Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
David J. Glass Nature Cell Biology5, 87–90
(February 2003); doi:10.1038/ncb0203-87
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article Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
Leo E. Otterbein, Brian S. Zuckerbraun, Manabu Haga, Fang Liu, Ruiping Song, Anny Usheva, Christina Stachulak, Natalya Bodyak, R. Neal Smith, Eva Csizmadia, Shivraj Tyagi, Yorihiro Akamatsu, Richard J. Flavell, Timothy R. Billiar, Edith Tzeng, Fritz H. Bach, Augustine M.K. Choi and Miguel P. Soares Nature Medicine9, 183–190
(February 2003); doi:10.1038/nm817
| Abstract | Full Text (HTML/PDF) |
article The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
Rommel G. Tirona, Wooin Lee, Brenda F. Leake, Lu-Bin Lan, Cynthia Brimer Cline, Vishal Lamba, Fereshteh Parviz, Stephen A. Duncan, Yusuke Inoue, Frank J. Gonzalez, Erin G. Schuetz and Richard B. Kim Nature Medicine9, 220–224
(February 2003); doi:10.1038/nm815
| Abstract | Full Text (HTML/PDF) |
original paper Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells
Kumar U. Kotlo, Furma Yehiely, Elena Efimova, Heather Harasty, Bahar Hesabi, Ksenya Shchors, Paz Einat, Ada Rozen, Eva Berent and Louis P Deiss Oncogene22, 797–806
(13 February 2003); doi:10.1038/sj.onc.1206077
| Abstract |
article VEGF: A modifier of the del22q11 (DiGeorge) syndrome?
Ingeborg Stalmans, Diether Lambrechts, Frederik De smet, Sandra Jansen, Jian Wang, Sunit Maity, Paige Kneer, Maren von der Ohe, Ann Swillen, Christa Maes, Marc Gewillig, Daniel G.M. Molin, Peter Hellings, Thurid Boetel, Maartin Haardt, Veerle Compernolle, Mieke Dewerchin, Stephane Plaisance, Robert Vlietinck, Beverly Emanuel, Adriana C. Gittenberger-de Groot, Peter Scambler, Bernice Morrow, Deborah A. Driscol, Lieve Moons, Camila V. Esguerra, Geert Carmeliet, Annett Behn-Krappa, Koen Devriendt, Désiré Collen, Simon J. Conway and Peter Carmeliet Nature Medicine9, 173–182
(February 2003); doi:10.1038/nm819
| Abstract | Full Text (HTML/PDF) |
January
review article Targeting tumours with genetically enhanced T lymphocytes
Michel Sadelain, Isabelle Rivière and Renier Brentjens Nature Reviews Cancer3, 35–45
(January 2003); doi:10.1038/nrc971
| Summary | Full Text (HTML / PDF) |
review article Scientific and therapeutic advances in antiplatelet therapy
Deepak L. Bhatt and Eric J. Topol Nature Reviews Drug Discovery2, 15–28
(January 2003); doi:10.1038/nrd985
| Summary | Full Text (HTML / PDF) |
article Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
Kamran Ghoreschi, Peter Thomas, Susanne Breit, Martin Dugas, Reinhard Mailhammer, Willem van Eden, Ruurd van der Zee, Tilo Biedermann, Jörg Prinz, Matthias Mack, Ulrich Mrowietz, Enno Christophers, Detlef Schlöndorff, Gerd Plewig, Christian A. Sander and Martin Röcken Nature Medicine9, 40–46
(January 2003); doi:10.1038/nm804
| Abstract | Full Text (HTML/PDF) |
review article Targeting RAS signalling pathways in cancer therapy
Julian Downward Nature Reviews Cancer3, 11–22
(January 2003); doi:10.1038/nrc969
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article Cytokine traps: multi-component, high-affinity blockers of cytokine action
Aris N. Economides, Laura Rocco Carpenter, John S. Rudge, Vivien Wong, Ellen M. Koehler-Stec, Christopher Hartnett, Erica A. Pyles, Xiaobing Xu, Thomas J. Daly, Michael R. Young, James P. Fandl, Frank Lee, Scott Carver, Jennifer McNay, Kevin Bailey, Swayampakula Ramakanth, Renta Hutabarat, Tammy T. Huang, Czeslaw Radziejewski, George D. Yancopoulos and Neil Stahl Nature Medicine9, 47–52
(January 2003); doi:10.1038/nm811
| Abstract | Full Text (HTML/PDF) |
news and views Setting the cytokine trap for autoimmunity
Charles A. Dinarello Nature Medicine9, 20–22
(January 2003); doi:10.1038/nm0103-20
| Full Text (HTML/PDF) |
review article Metastasis suppressors alter the signal transduction of cancer cells
Patricia S. Steeg Nature Reviews Cancer3, 55–63
(January 2003); doi:10.1038/nrc967
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