Cell signaling research papers - Clinical / Drug discovery - Signaling Update

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Research library: Clinical / Drug discovery

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December

article
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
Natalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G G C Verhoef, Maria Masucci, Aladdin Pramanik and Galina Selivanova
Nature Medicine 10, 1321–1328
(December 2004); doi:10.1038/nm1146
| Abstract | Full Text (HTML/PDF) |

news and views
Cancer drug discovery: the wisdom of imprecision
Andrei V Gudkov
Nature Medicine 10, 1298–1299
(December 2004); doi:10.1038/nm1204-1298
| Full Text (HTML/PDF) |

perspectives
Timeline: Gefitinib — a novel targeted approach to treating cancer
Roy S. Herbst, Masahiro Fukuoka and José Baselga
Nature Reviews Cancer 4, 956–965
(December 2004); doi:10.1038/nrc1506
| Abstract | Full Text (HTML / PDF) |

review article
Plasmacytoid dendritic cells in immunity
Marco Colonna, Giorgio Trinchieri and Yong-Jun Liu
Nature Immunology 5, 1219–1226
(December 2004); doi:10.1038/ni1141
| Abstract | Full Text (HTML/PDF) |

review article
Strategies to overcome resistance to targeted protein kinase inhibitors
Henrik Daub, Katja Specht and Axel Ullrich
Nature Reviews Drug Discovery 3, 1001–1010
(December 2004); doi:10.1038/nrd1579
| Abstract | Full Text (HTML / PDF) |

review article
The immunogenetics of asthma and eczema: a new focus on the epithelium
William Cookson
Nature Reviews Immunology 4, 978–988
(December 2004); doi:10.1038/nri1500
| Abstract | Full Text (HTML / PDF) |

article
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
Weijia Kong, Jing Wei, Parveen Abidi, Meihong Lin, Satoru Inaba, Cong Li, Yanling Wang, Zizheng Wang, Shuyi Si, Huaining Pan, Shukui Wang, Jingdan Wu, Yue Wang, Zhuorong Li, Jingwen Liu and Jian-Dong Jiang
Nature Medicine 10, 1344–1351
(December 2004); doi:10.1038/nm1135
| Abstract | Full Text (HTML/PDF) |

article
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
Antonio Moschetta, Angie L Bookout and David J Mangelsdorf
Nature Medicine 10, 1352–1358
(December 2004); doi:10.1038/nm1138
| Abstract | Full Text (HTML/PDF) |

news and views
Chipping away at gallstones
Kerry B Goralski and Christopher J Sinal
Nature Medicine 10, 1301–1302
(December 2004); doi:10.1038/nm1204-1301
| Full Text (HTML/PDF) |

review article
Aurora-kinase inhibitors as anticancer agents
Nicholas Keen and Stephen Taylor
Nature Reviews Cancer 4, 927–936
(December 2004); doi:10.1038/nrc1502
| Abstract | Full Text (HTML / PDF) |

review article
Targeting the mitogen-activated protein kinase cascade to treat cancer
Judith S. Sebolt-Leopold and Roman Herrera
Nature Reviews Cancer 4, 937–947
(December 2004); doi:10.1038/nrc1503
| Abstract | Full Text (HTML / PDF) |

research article
Lack of interferon response in animals to naked siRNAs
Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche and Mark E Davis
Nature Biotechnology 22, 1579–1582
(December 2004); doi:10.1038/nbt1038
| First Paragraph | Full Text (HTML/PDF) |

review article
Development of TGF-β signalling inhibitors for cancer therapy
Jonathan M. Yingling, Kerry L. Blanchard and J. Scott Sawyer
Nature Reviews Drug Discovery 3, 1011–1022
(December 2004); doi:10.1038/nrd1580
| Abstract | Full Text (HTML / PDF) |

article
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
Tian Wang, Terrence Town, Lena Alexopoulou, John F Anderson, Erol Fikrig and Richard A Flavell
Nature Medicine 10, 1366–1373
(December 2004); doi:10.1038/nm1140
| Abstract | Full Text (HTML/PDF) |

news and views
West Nile virus: crossing the blood-brain barrier
Michael S Diamond and Robyn S Klein
Nature Medicine 10, 1294–1295
(December 2004); doi:10.1038/nm1204-1294
| Full Text (HTML/PDF) |

review article
Making protein interactions druggable: targeting PDZ domains
Kumlesh K. Dev
Nature Reviews Drug Discovery 3, 1047–1056
(December 2004); doi:10.1038/nrd1578
| Summary | Full Text (HTML / PDF) |

review
The evolution of chronic infection strategies in the α-proteobacteria
Jacques Batut, Siv G. E. Andersson and David O'Callaghan
Nature Reviews Microbiology 2, 933–945
(December 01 2004); doi:10.1038/nrmicro1044
| Abstract | Full Text (HTML/PDF) |

November

article
Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Ildiko Bock-Marquette , Ankur Saxena , Michael D. White, J. Michael DiMaio and Deepak Srivastava
Nature 432, 466–472
(25 November 2004); doi:10.1038/nature03000
| Abstract | Full Text (HTML / PDF) |

news and views
Regenerative medicine: Prometheus unbound
Michael D. Schneider
Nature 432, 451–453
(25 November 2004); doi:10.1038/432451a
| Full Text (HTML / PDF) |

letters to nature
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
Marcus Maurer , Jochen Wedemeyer , Martin Metz , Adrian M. Piliponsky, Karsten Weller, Devavani Chatterjea, David E. Clouthier, Masashi M. Yanagisawa , Mindy Tsai and Stephen J. Galli
Nature 432, 512–516
(25 November 2004); doi:10.1038/nature03085
| First Paragraph | Full Text (HTML / PDF) |

review article
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
Dennis J. Selkoe
Nature Cell Biology 6, 1054–1061
(November 2004); doi:10.1038/ncb1104-1054
| Abstract | Full Text (HTML/PDF) |

news and views
Transporter of a malaria catastrophe
Thomas E Wellems
Nature Medicine 10, 1169–1171
(November 2004); doi:10.1038/nm1104-1169
| Full Text (HTML/PDF) |

review article
Principles for modulation of the nuclear receptor superfamily
Hinrich Gronemeyer, Jan-Åke Gustafsson and Vincent Laudet
Nature Reviews Drug Discovery 3, 950–964
(November 2004); doi:10.1038/nrd1551
| Abstract | Full Text (HTML / PDF) |

review article
The many faces of filamin: A versatile molecular scaffold for cell motility and signalling
Yuanyi Feng and Christopher A. Walsh
Nature Cell Biology 6, 1034–1038
(November 2004); doi:10.1038/ncb1104-1034
| Abstract | Full Text (HTML/PDF) |

review article
Clinical strategies for expansion of haematopoietic stem cells
Brian P. Sorrentino
Nature Reviews Immunology 4, 878–888
(November 2004); doi:10.1038/nri1487
| Abstract | Full Text (HTML / PDF) |

perspectives
Lifespan and mitochondrial control of neurodegeneration
Alan F Wright, Samuel G Jacobson, Artur V Cideciyan, Alejandro J Roman, Xinhua Shu, Dafni Vlachantoni, Roderick R McInnes and Rudolph A Riemersma
Nature Genetics 36, 1153–1158
(November 2004); doi:10.1038/ng1448
| Abstract | Full Text (HTML/PDF) |

review article
Molecular genetics and genomics of heart failure
Choong-Chin Liew and Victor J. Dzau
Nature Reviews Genetics 5, 811–825
(November 2004); doi:10.1038/nrg1470
| Abstract | Full Text (HTML / PDF) |

news and views
Medicine: A cholesterol connection in RNAi
John J. Rossi
Nature 432, 155–156
(11 November 2004); doi:10.1038/432155a
| Full Text (HTML / PDF) |

article
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Hong Wang, Hong Liao, Mahendar Ochani, Marilou Justiniani, Xinchun Lin, Lihong Yang, Yousef Al-Abed, Haichao Wang, Christine Metz, Edmund J Miller, Kevin J Tracey and Luis Ulloa
Nature Medicine 10, 1216–1221
(November 2004); doi:10.1038/nm1124
| Abstract | Full Text (HTML/PDF) |

review article
The emerging roles of human tissue kallikreins in cancer
Carla A. Borgoño and Eleftherios P. Diamandis
Nature Reviews Cancer 4, 876–890
(November 2004); doi:10.1038/nrc1474
| Abstract | Full Text (HTML / PDF) |

letter
X-linked inheritance of Fanconi anemia complementation group B
Amom Ruhikanta Meetei, Marieke Levitus, Yutong Xue, Annette L Medhurst, Michel Zwaan, Chen Ling, Martin A Rooimans, Patrick Bier, Maureen Hoatlin, Gerard Pals, Johan P de Winter, Weidong Wang and Hans Joenje
Nature Genetics 36, 1219–1224
(November 2004); doi:10.1038/ng1458
| First Paragraph | Full Text (HTML/PDF) |

news and views
A new gene on the X involved in Fanconi anemia
Nazneen Rahman and Alan Ashworth
Nature Genetics 36, 1142–1143
(November 2004); doi:10.1038/ng1104-1142
| Full Text (HTML/PDF) |

review article
RNA and microRNAs in fragile X mental retardation
Peng Jin, Reid S. Alisch and Stephen T. Warren
Nature Cell Biology 6, 1048–1053
(November 2004); doi:10.1038/ncb1104-1048
| Abstract | Full Text (HTML/PDF) |

review article
A-type lamins: Guardians of the soma?
Chris J. Hutchison and Howard J. Worman
Nature Cell Biology 6, 1062–1067
(November 2004); doi:10.1038/ncb1104-1062
| Abstract | Full Text (HTML/PDF) |

review article
Strategies to enhance T-cell reconstitution in immunocompromised patients
Marcel R. M. van den Brink, Önder Alpdogan and Richard L. Boyd
Nature Reviews Immunology 4, 856–867
(November 2004); doi:10.1038/nri1484
| Abstract | Full Text (HTML / PDF) |

article
Salt-sensitive hypertension is triggered by Ca²⁺ entry via Na⁺/Ca²⁺ exchanger type-1 in vascular smooth muscle
Takahiro Iwamoto, Satomi Kita, Jin Zhang, Mordecai P Blaustein, Yuji Arai, Shigeru Yoshida, Koji Wakimoto, Issei Komuro and Takeshi Katsuragi
Nature Medicine 10, 1193–1199
(November 2004); doi:10.1038/nm1118
| Abstract | Full Text (HTML/PDF) |

news and views
Hypertension with a grain of salt
Ursula Danilczyk and Josef Penninger
Nature Medicine 10, 1163–1164
(November 2004); doi:10.1038/nm1104-1163
| Full Text (HTML/PDF) |

review article
Antitumour effects of antiretroviral therapy
Paolo Monini, Cecilia Sgadari, Elena Toschi, Giovanni Barillari and Barbara Ensoli
Nature Reviews Cancer 4, 861–875
(November 2004); doi:10.1038/nrc1479
| Abstract | Full Text (HTML / PDF) |

letter
Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
Jan Hellemans, Olena Preobrazhenska, Andy Willaert, Philippe Debeer, Peter C M Verdonk, Teresa Costa, Katrien Janssens, Bjorn Menten, Nadine Van Roy, Stefan J T Vermeulen, Ravi Savarirayan, Wim Van Hul, Filip Vanhoenacker, Danny Huylebroeck, Anne De Paepe, Jean-Marie Naeyaert, Jo Vandesompele, Frank Speleman, Kristin Verschueren, Paul J Coucke and Geert R Mortier
Nature Genetics 36, 1213–1218
(November 2004); doi:10.1038/ng1453
| First Paragraph | Full Text (HTML/PDF) |

review article
Iron, brain ageing and neurodegenerative disorders
Luigi Zecca, Moussa B. H. Youdim, Peter Riederer, James R. Connor and Robert R. Crichton
Nature Reviews Neuroscience 5, 863–873
(November 2004); doi:10.1038/nrn1537
| Abstract | Full Text (HTML / PDF) |

review article
Functional genomics to new drug targets
Richard Kramer and Dalia Cohen
Nature Reviews Drug Discovery 3, 965–972
(November 2004); doi:10.1038/nrd1552
| Abstract | Full Text (HTML / PDF) |

October

review article
Liver regeneration: from myth to mechanism
Rebecca Taub
Nature Reviews Molecular Cell Biology 5, 836–847
(October 2004); doi:10.1038/nrm1489
| Abstract | Full Text (HTML / PDF) |

review article
Gene therapy for autoimmune diseases: quo vadis?
Yuti Chernajovsky, David J. Gould and Osvaldo L. Podhajcer
Nature Reviews Immunology 4, 800–811
(October 2004); doi:10.1038/nri1459
| Abstract | Full Text (HTML / PDF) |

article
Selective inactivation or reconstitution of adenosine A_2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz and Jiang-Fan Chen
Nature Medicine 10, 1081–1087
(October 2004); doi:10.1038/nm1103
| Abstract | Full Text (HTML/PDF) |

news and views
Bone marrow spawns brain killers
Costantino Iadecola
Nature Medicine 10, 1044–1045
(October 2004); doi:10.1038/nm1004-1044
| Full Text (HTML/PDF) |

brief communication
Nonsteroidal anti-inflammatory drugs lower Aβ₄₂ and change presenilin 1 conformation
Alberto Lleó, Oksana Berezovska, Lauren Herl, Susan Raju, Amy Deng, Brian J Bacskai, Matthew P Frosch, Michael Irizarry and Bradley T Hyman
Nature Medicine 10, 1065–1066
(October 2004); doi:10.1038/nm1112
| First Paragraph | Full Text (HTML/PDF) |

review article
High interstitial fluid pressure — an obstacle in cancer therapy
Carl-Henrik Heldin, Kristofer Rubin, Kristian Pietras and Arne Östman
Nature Reviews Cancer 4, 806–813
(October 2004); doi:10.1038/nrc1456
| Abstract | Full Text (HTML / PDF) |

review article
Glycomics: a pathway to a class of new and improved therapeutics
Zachary Shriver, S. Raguram and Ram Sasisekharan
Nature Reviews Drug Discovery 3, 863–873
(October 2004); doi:10.1038/nrd1521
| Abstract | Full Text (HTML / PDF) |

letters to nature
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan and Bart Vanhaesebroeck
Nature 431, 1007–1011
(21 October 2004); doi:10.1038/nature02991
| First Paragraph | Full Text (HTML / PDF) |

article
Aberrant cannabinoid signaling impairs oviductal transport of embryos
Haibin Wang, Yong Guo, Dingzhi Wang, Philip J Kingsley, Lawrence J Marnett, Sanjoy K Das, Raymond N DuBois and Sudhansu K Dey
Nature Medicine 10, 1074–1080
(October 2004); doi:10.1038/nm1104
| Abstract | Full Text (HTML/PDF) |

article
4-1BB-mediated immunotherapy of rheumatoid arthritis
Su K Seo, Jae H Choi, Young H Kim, Woo J Kang, Hye Y Park, Jae H Suh, Beom K Choi, Dass S Vinay and Byoung S Kwon
Nature Medicine 10, 1088–1094
(October 2004); doi:10.1038/nm1107
| Abstract | Full Text (HTML/PDF) |

news and views
Suppressing the self in rheumatoid arthritis
Robert S Mittler
Nature Medicine 10, 1047–1049
(October 2004); doi:10.1038/nm1004-1047
| Full Text (HTML/PDF) |

review article
Bradykinin receptor ligands: therapeutic perspectives
François Marceau and Domenico Regoli
Nature Reviews Drug Discovery 3, 845–852
(October 2004); doi:10.1038/nrd1522
| Abstract | Full Text (HTML / PDF) |

letter
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Dan Kawamori, Taka-aki Matsuoka, Munehide Matsuhisa, Yoshitaka Kajimoto, Hidenori Ichijo, Yoshimitsu Yamasaki and Masatsugu Hori
Nature Medicine 10, 1128–1132
(October 2004); doi:10.1038/nm1111
| First Paragraph | Full Text (HTML/PDF) |

news and views
Hematopoietic stem cells get closer to the bone
Connie Eaves
Nature Medicine 10, 1042–1044
(October 2004); doi:10.1038/nm1004-1042
| Full Text (HTML/PDF) |

review article
Polyamines and cancer: old molecules, new understanding
Eugene W. Gerner and Frank L. Meyskens Jr
Nature Reviews Cancer 4, 781–792
(January 2004); doi:10.1038/nrc1454
| Abstract | Full Text (HTML / PDF) |

technical report
Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis
Fabian Kiessling, Susanne Greschus, Matthias P Lichy, Michael Bock, Christian Fink, Silvia Vosseler, Jens Moll, Margareta M Mueller, Norbert E. Fusenig, Horst Traupe and Wolfhard Semmler
Nature Medicine 10, 1133–1138
(October 2004); doi:10.1038/nm1101
| First Paragraph | Full Text (HTML/PDF) |

article
Vascular endothelial growth factor (VEGF) induces remodeling and enhances T_H2-mediated sensitization and inflammation in the lung
Chun Geun Lee, Holger Link, Peter Baluk, Robert J Homer, Svetlana Chapoval, Vineet Bhandari, Min Jong Kang, Lauren Cohn, Yoon Keun Kim, Donald M McDonald and Jack A Elias
Nature Medicine 10, 1095–1103
(October 2004); doi:10.1038/nm1105
| Abstract | Full Text (HTML/PDF) |

news and views
VEGF obstructs the lungs
Marc E Rothenberg
Nature Medicine 10, 1041–1042
(October 2004); doi:10.1038/nm1004-1041
| Full Text (HTML/PDF) |

review article
New drugs for asthma
Peter J. Barnes
Nature Reviews Drug Discovery 3, 831–844
(October 2004); doi:10.1038/nrd1524
| Abstract | Full Text (HTML / PDF) |

September

article
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Tyler J Curiel, George Coukos, Linhua Zou, Xavier Alvarez, Pui Cheng, Peter Mottram, Melina Evdemon-Hogan, Jose R Conejo-Garcia, Lin Zhang, Matthew Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, Ben Daniel, Alan Gordon, Leann Myers, Andrew Lackner, Mary L Disis, Keith L Knutson, Lieping Chen and Weiping Zou
Nature Medicine 10, 942–949
(September 2004); doi:10.1038/nm1093
| Abstract | Full Text (HTML/PDF) |

news and views
Fatal attraction: tumors beckon regulatory T cells
Ethan M Shevach
Nature Medicine 10, 900–901
(September 2004); doi:10.1038/nm0904-900
| Full Text (HTML/PDF) |

news and views
Mutated matrix gene mars macula
Charlotte Schubert
Nature Medicine 10, 903
(September 2004); doi:10.1038/nm0904-903
| Full Text (HTML/PDF) |

news and views
Maiming mitochondria in familial ALS
Valina L Dawson
Nature Medicine 10, 905–906
(September 2004); doi:10.1038/nm0904-905
| Full Text (HTML/PDF) |

letter
Mutations in SLC6A19, encoding B⁰AT1, cause Hartnup disorder
Robert Kleta, Elisa Romeo, Zorica Ristic, Toshihiro Ohura, Caroline Stuart, Mauricio Arcos-Burgos, Mital H Dave, Carsten A Wagner, Simone R M Camargo, Sumiko Inoue, Norio Matsuura, Amanda Helip-Wooley, Detlef Bockenhauer, Richard Warth, Isa Bernardini, Gepke Visser, Thomas Eggermann, Philip Lee, Arthit Chairoungdua, Promsuk Jutabha, Ellappan Babu, Sirinun Nilwarangkoon, Naohiko Anzai, Yoshikatsu Kanai, Francois Verrey, William A Gahl and Akio Koizumi
Nature Genetics 36, 999–1002
(September 2004); doi:10.1038/ng1405
| First Paragraph | Full Text (HTML/PDF) |

letter
Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19
Heng F Seow, Stefan Bröer, Angelika Bröer, Charles G Bailey, Simon J Potter, Juleen A Cavanaugh and John E J Rasko
Nature Genetics 36, 1003–1007
(September 2004); doi:10.1038/ng1406
| First Paragraph | Full Text (HTML/PDF) |

review article
Molecular and neuronal substrates for general anaesthetics
Uwe Rudolph and Bernd Antkowiak
Nature Reviews Neuroscience 5, 709–720
(September 2004); doi:10.1038/nrn1496
| Abstract | Full Text (HTML / PDF) |

research article
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
Raewyn M Seaberg, Simon R Smukler, Timothy J Kieffer, Grigori Enikolopov, Zeenat Asghar, Michael B Wheeler, Gregory Korbutt and Derek van der Kooy
Nature Biotechnology 22, 1115–1124
(September 2004); doi:10.1038/nbt1004
| Abstract | Full Text (HTML/PDF) |

news and views
β-cell precursors—a work in progress
Gordon C Weir and Susan Bonner-Weir
Nature Biotechnology 22, 1095–1096
(September 2004); doi:10.1038/nbt0904-1095
| Full Text (HTML/PDF) |

review article
The endocannabinoid system and its therapeutic exploitation
Vincenzo Di Marzo, Maurizio Bifulco and Luciano De Petrocellis
Nature Reviews Drug Discovery 3, 771–784
(September 2004); doi:10.1038/nrd1495
| Abstract | Full Text (HTML / PDF) |

review article
Gene-promoter hypermethylation as a biomarker in lung cancer
Steven A. Belinsky
Nature Reviews Cancer 4, 707–717
(September 2004); doi:10.1038/nrc1432
| Abstract | Full Text (HTML / PDF) |

review article
WNT and β-catenin signalling: diseases and therapies
Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari and Ajamete Kaykas
Nature Reviews Genetics 5, 691–701
(September 2004); doi:10.1038/nrg1427
| Abstract | Full Text (HTML / PDF) |

review article
Strategies for disease modification in Alzheimer's disease
Martin Citron
Nature Reviews Neuroscience 5, 677–685
(September 2004); doi:10.1038/nrn1495
| Abstract | Full Text (HTML / PDF) |

letters to nature
A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
Michael B. Reed, Pilar Domenech, Claudia Manca, Hua Su, Amy K. Barczak, Barry N. Kreiswirth, Gilla Kaplan and Clifton E. Barry III
Nature 431, 84–87
(02 September 2004); doi:10.1038/nature02837
| First Paragraph | Full Text (HTML / PDF) |

review article
Tolerance, not immunity, crucially depends on IL–2
Thomas R. Malek and Allison L. Bayer
Nature Reviews Immunology 4, 665–674
(September 2004); doi:10.1038/nri1435
| Summary | Full Text (HTML / PDF) |

article
The 5–lipoxygenase pathway promotes pathogenesis of hyperlipidemia–dependent aortic aneurysm
Lei Zhao, Michael P W Moos, Rolf Gräbner, Frédérique Pédrono, Jinjin Fan, Brigitte Kaiser, Nicole John, Sandra Schmidt, Rainer Spanbroek, Katharina Lötzer, Li Huang, Jisong Cui, Daniel J Rader, Jilly F Evans, Andreas J R Habenicht and Colin D Funk
Nature Medicine 10, 966–973
(September 2004); doi:10.1038/nm1099
| Abstract | Full Text (HTML/PDF) |

news and views
Aneurysms: leukotrienes weaken aorta from the outside
Wulf Palinski
Nature Medicine 10, 896–898
(September 2004); doi:10.1038/nm0904–896
| Full Text (HTML/PDF) |

August

article
P2X7 receptor inhibition improves recovery after spinal cord injury
Xiaohai Wang, Gregory Arcuino, Takahiro Takano, Jane Lin, Wei Guo Peng, Pinglan Wan, Pingjia Li, Qiwu Xu, Qing Song Liu, Steven A Goldman and Maiken Nedergaard
Nature Medicine 10, 821–827
(August 2004); doi:10.1038/nm1082
| Abstract | Full Text (HTML/PDF) |

news and views
Tracking down huntingtin
Juan Carlos López
Nature Medicine 10, 776
(August 2004); doi:10.1038/nm0804-776
| Full Text (HTML/PDF) |

review article
Biologically active sphingolipids in cancer pathogenesis and treatment
Besim Ogretmen and Yusuf A. Hannun
Nature Reviews Cancer 4, 604–616
(August 2004); doi:10.1038/nrc1411
| Summary | Full Text (HTML / PDF) |

letters to nature
Chemical remodelling of cell surfaces in living animals
Jennifer A. Prescher, Danielle H. Dube and Carolyn R. Bertozzi
Nature 430, 873–877
(19 August 2004); doi:10.1038/nature02791
| First Paragraph | Full Text (HTML / PDF) |

news and views
Chemical biology: Hitting the sweet spot
David A. Tirrell
Nature 430, 837
(19 August 2004); doi:10.1038/430837a
| Full Text (HTML / PDF) |

review article
Fibrotic disease and the T_H1/T_H2 paradigm
Thomas A. Wynn
Nature Reviews Immunology 4, 583–594
(August 2004); doi:10.1038/nri1412
| Summary | Full Text (HTML / PDF) |

review article
Lipid metabolic enzymes: emerging drug targets for the treatment of obesity
Yuguang Shi and Paul Burn
Nature Reviews Drug Discovery 3, 695–710
(August 2004); doi:10.1038/nrd1469
| Summary | Full Text (HTML / PDF) |

letter
Heterozygous TGFBR2 mutations in Marfan syndrome
Takeshi Mizuguchi, Gwenaëlle Collod-Beroud, Takushi Akiyama, Marianne Abifadel, Naoki Harada, Takayuki Morisaki, Delphine Allard, Mathilde Varret, Mireille Claustres, Hiroko Morisaki, Makoto Ihara, Akira Kinoshita, Koh-ichiro Yoshiura, Claudine Junien, Tadashi Kajii, Guillaume Jondeau, Tohru Ohta, Tatsuya Kishino, Yoichi Furukawa, Yusuke Nakamura, Norio Niikawa, Catherine Boileau and Naomichi Matsumoto
Nature Genetics 36, 855–860
(August 2004); doi:10.1038/ng1392
| First Paragraph | Full Text (HTML/PDF) |

news and views
TGFβ signaling in health and disease
Rosemary J Akhurst
Nature Genetics 36, 790–792
(August 2004); doi:10.1038/ng0804-790
| Full Text (HTML/PDF) |

research article
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
Sunil Shaunak, Sharyn Thomas, Elisabetta Gianasi, Antony Godwin, Emma Jones, Ian Teo, Kamiar Mireskandari, Philip Luthert, Ruth Duncan, Steve Patterson, Peng Khaw and Steve Brocchini
Nature Biotechnology 22, 977–984
(August 2004); doi:10.1038/nbt995
| Abstract | Full Text (HTML/PDF) |

review article
Pathways towards and away from Alzheimer's disease
Mark P. Mattson
Nature 430, 631–639
(05 August 2004); doi:10.1038/nature02621
| Abstract | Full Text (HTML / PDF) |

July

review article
A new modality for immunosuppression: targeting the JAK/STAT pathway
John J. O'Shea, Marko Pesu, Dominic C. Borie and Paul S. Changelian
Nature Reviews Drug Discovery 3, 555–564
(July 2004); doi:10.1038/nrd1441
| Abstract | Full Text (HTML / PDF) |

review article
The neurobiology of antiepileptic drugs
Michael A. Rogawski and Wolfgang Löscher
Nature Reviews Neuroscience 5, 553–564
(July 2004); doi:10.1038/nrn1430
| Abstract | Full Text (HTML / PDF) |

article
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Makoto Inoue, Md Harunor Rashid, Ryousuke Fujita, James J A Contos, Jerold Chun and Hiroshi Ueda
Nature Medicine 10, 712–718
(July 2004); doi:10.1038/nm1060
| Abstract | Full Text (HTML/PDF) |

review article
Novel therapeutic approaches for heart failure by normalizing calcium cycling
Xander H. T. Wehrens and Andrew R. Marks
Nature Reviews Drug Discovery 3, 565–574
(July 2004); doi:10.1038/nrd1440
| Abstract | Full Text (HTML / PDF) |

review article
Therapeutics targeting the innate immune system
Richard J. Ulevitch
Nature Reviews Immunology 4, 512–520
(July 2004); doi:10.1038/nri1396
| Abstract | Full Text (HTML / PDF) |

news and views
Cannabinoids cool the intestine
George Kunos and Pál Pacher
Nature Medicine 10, 678–679
(July 2004); doi:10.1038/nm0704-678
| Full Text (HTML/PDF) |

news and views
LARGE can functionally bypass -dystroglycan glycosylation defects in distinct congenital muscular dystrophies
Rita Barresi, Daniel E Michele, Motoi Kanagawa, Hollie A Harper, Sherri A Dovico, Jakob S Satz, Steven A Moore, Wenli Zhang, Harry Schachter, Jan P Dumanski, Ronald D Cohn, Ichizo Nishino & Kevin P Campbell
Nature Medicine 10, 696–703
(July 2004); doi:10.1038/nm1059
| Abstract | Full Text (HTML/PDF) |

news and views
Glycosylation eases muscular dystrophy
Francesco Muntoni, Martin Brockington and Susan C Brown
Nature Medicine 10, 676–677
(July 2004); doi:10.1038/nm0704-676
| Full Text (HTML/PDF) |

June

review article
Therapeutic potential of oral tolerance
Lloyd Mayer and Ling Shao
Nature Reviews Immunology 4, 407–419
(June 2004); doi:10.1038/nri1370
| Abstract | Full Text (HTML / PDF) |

article
Reversal of obesity by targeted ablation of adipose tissue
Mikhail G Kolonin, Pradip K Saha, Lawrence Chan, Renata Pasqualini and Wadih Arap
Nature Medicine 10, 625–632
(June 2004); doi:10.1038/nm1048
| Abstract | Full Text (HTML/PDF) |

news and views
Magic bullets melt fat
Marc L Reitman
Nature Medicine 10, 581–582
(June 2004); doi:10.1038/nm0604-581
| Full Text (HTML/PDF) |

review article
Exploiting tumour hypoxia in cancer treatment
J. Martin Brown and William R. Wilson
Nature Reviews Cancer 4, 437–447
(June 2004); doi:10.1038/nrc1367
| Abstract | Full Text (HTML / PDF) |

review article
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
Kazuo Sugamura, Naoto Ishii and Andrew D. Weinberg
Nature Reviews Immunology 4, 420–431
(June 2004); doi:10.1038/nri1371
| Abstract | Full Text (HTML / PDF) |

article
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice
Sören T Eichhorst, Andreas Krueger, Susanne Müerköster, Stefanie C Fas, Alexander Golks, Uwe Gruetzner, Louise Schubert, Christine Opelz, Manfred Bilzer, Alexander L Gerbes and Peter H Krammer
Nature Medicine 10, 602–609
(June 2004); doi:10.1038/nm1049
| Abstract | Full Text (HTML/PDF) |

news and views
Cheating death in the liver
M Eugenia Guicciardi and Gregory J Gores
Nature Medicine 10, 587–588
(June 2004); doi:10.1038/nm0604-587
| Full Text (HTML/PDF) |

review article
The anti-angiogenic basis of metronomic chemotherapy
Robert S. Kerbel and Barton A. Kamen
Nature Reviews Cancer 4, 423–436
(June 2004); doi:10.1038/nrc1369
| Abstract | Full Text (HTML / PDF) |

article
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy
Phil Oh, Yan Li, Jingyi Yu, Eberhard Durr, Karolina M. Krasinska, Lucy A. Carver, Jacqueline E. Testa and Jan E. Schnitzer
Nature 429, 629–635
(10 June 2004); doi:10.1038/nature02580
| Abstract | Full Text (HTML / PDF) |

news and views
Molecular medicine: The writing is on the vessel wall
Christopher H. Contag and Michael H. Bachmann
Nature 429, 618–619
(10 June 2004); doi:10.1038/429618a
| Full Text (HTML / PDF) |

article
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane and William R Sellers
Nature Medicine 10, 594–601
(June 2004); doi:10.1038/nm1052
| Abstract | Full Text (HTML/PDF) |

news and views
TORward AKTually useful mouse models
Ingo K Mellinghoff and Charles L Sawyers
Nature Medicine 10, 579–580
(June 2004); doi:10.1038/nm0604-579
| Full Text (HTML/PDF) |

article
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane and David C Rubinsztein
Nature Genetics 36, 585–595
(June 2004); doi:10.1038/ng1362
| Abstract | Full Text (HTML/PDF) |

news and views
Huntingtin aggregates ask to be eaten
Carson C Thoreen and David M Sabatini
Nature Genetics 36, 553–554
(June 2004); doi:10.1038/ng0604-553
| Full Text (HTML/PDF) |

review article
GSK3 inhibitors: development and therapeutic potential
Philip Cohen and Michel Goedert
Nature Reviews Drug Discovery 3, 479–487
(June 2004); doi:10.1038/nrd1415
| Abstract | Full Text (HTML / PDF) |

article
Selective inhibition of NF-kB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
Eijiro Jimi, Kazuhiro Aoki, Hiroaki Saito, Fulvio D'Acquisto, Michael J May, Ichiro Nakamura, Testuo Sudo, Takefumi Kojima, Fujio Okamoto, Hidefumi Fukushima, Koji Okabe, Keiichi Ohya and Sankar Ghosh
Nature Medicine 10, 617–624
(June 2004); doi:10.1038/nm1054
| Abstract | Full Text (HTML/PDF) |

article
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
Damien D Pearse, Francisco C Pereira, Alexander E Marcillo, Margaret L Bates, Yerko A Berrocal, Marie T Filbin and Mary Bartlett Bunge
Nature Medicine 10, 610–616
(June 2004); doi:10.1038/nm1056
| Abstract | Full Text (HTML/PDF) |

perspectives
Opinion: Yeast as a model system for anticancer drug discovery
Julian A. Simon and Antonio Bedalov
Nature Reviews Cancer 4, 481– 487
(June 2004); doi:10.1038/nrc1372
| Abstract | Full Text (HTML / PDF) |

review article
Targeted therapy for brain tumours
Maciej S. Lesniak and Henry Brem
Nature Reviews Drug Discovery 3, 499–508
(June 2004); doi:10.1038/nrd1414
| Abstract | Full Text (HTML / PDF) |

May

letters to nature
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
Mimoun Azzouz, G. Scott Ralph, Erik Storkebaum, Lucy E. Walmsley, Kyriacos A. Mitrophanous, Susan M. Kingsman, Peter Carmeliet and Nicholas D. Mazarakis
Nature 429, 413–417
(27 May 2004); doi:10.1038/nature02544
| First Paragraph | Full Text (HTML / PDF) |

article
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
Mattias Belting, Michael I Dorrell, Staffan Sandgren, Edith Aguilar, Jasimuddin Ahamed, Andrea Dorfleutner, Peter Carmeliet, Barbara M Mueller, Martin Friedlander and Wolfram Ruf
Nature Medicine 10, 502–509
(May 2004); doi:10.1038/nm1037
| Abstract | Full Text (HTML/PDF) |

review article
Molecules and mechanisms of the graft-versus-leukaemia effect
Marie Bleakley and Stanley R. Riddell
Nature Reviews Cancer 4, 371–380
(May 2004); doi:10.1038/nrc1365
| Abstract | Full Text (HTML / PDF) |

article
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
Yiping Yang, Ching-Tai Huang, Xiaopei Huang and Drew M Pardoll
Nature Immunology 5, 508–515
(May 2004); doi:10.1038/ni1059
| Abstract | Full Text (HTML/PDF) |

perspectives
Timeline: The discovery of receptor tyrosine kinases: targets for cancer therapy
Andreas Gschwind, Oliver M. Fischer and Axel Ullrich
Nature Reviews Cancer 4, 361–370
(May 2004); doi:10.1038/nrc1360
| Abstract | Full Text (HTML / PDF) |

article
Increased airway epithelial Na⁺ absorption produces cystic fibrosis-like lung disease in mice
Marcus Mall, Barbara R Grubb, Jack R Harkema, Wanda K O'Neal and Richard C Boucher
Nature Medicine 10, 487–493
(May 2004); doi:10.1038/nm1028
| Abstract | Full Text (HTML/PDF) |

news and views
Finally, mice with CF lung disease
Raymond A Frizzell and Joseph M Pilewski
Nature Medicine 10, 452–454
(May 2004); doi:10.1038/nm0504-452
| Full Text (HTML/PDF) |

review article
The TOR pathway: a target for cancer therapy
Mary-Ann Bjornsti and Peter J. Houghton
Nature Reviews Cancer 4, 335–348
(May 2004); doi:10.1038/nrc1362
| Abstract | Full Text (HTML / PDF) |

review article
Time to draw breath: asthma-susceptibility genes are identified
Marsha Wills-Karp and Susan L. Ewart
Nature Reviews Genetics 5, 376–387
(May 2004); doi:10.1038/nrg1326
| Abstract | Full Text (HTML / PDF) |

review article
Experimental therapeutics in transgenic mouse models of Huntington's disease
M. Flint Beal and Robert J. Ferrante
Nature Reviews Neuroscience 5, 373–384
(May 2004); doi:10.1038/nrn1386
| Abstract | Full Text (HTML / PDF) |

review article
The proteasome: a suitable antineoplastic target
Julian Adams
Nature Reviews Cancer 4, 349–360
(May 2004); doi:10.1038/nrc1361
| Abstract | Full Text (HTML / PDF) |

research article
High-affinity binders selected from designed ankyrin repeat protein libraries
H Kaspar Binz, Patrick Amstutz, Andreas Kohl, Michael T Stumpp, Christophe Briand, Patrik Forrer, Markus G Grütter and Andreas Plückthun
Nature Biotechnology 22, 575–582
(May 2004); doi:10.1038/nbt962
| Abstract | Full Text (HTML/PDF) |

news and views
Next-generation protein drugs
Ian M Tomlinson
Nature Biotechnology 22, 521–522
(May 2004); doi:10.1038/nbt0504-521
| Full Text (HTML/PDF) |

April

letter
Gating of CFTR by the STAS domain of SLC26 transporters
Shigeru B.H. Ko, Weizhong Zeng, Michael R. Dorwart, Xiang Luo, Kil Hwan Kim, Linda Millen, Hidemi Goto, Satoru Naruse, Abigail Soyombo, Philip J. Thomas and Shmuel Muallem
Nature Cell Biology 6, 343–350
(April 2004); doi:10.1038/ncb1115
| First Paragraph | Full Text (HTML/PDF) |

news and views
Bicarbonate secretion: it takes two to tango
Michael A. Gray
Nature Cell Biology 6, 292–294
(April 2004); doi:10.1038/ncb0404-292
| Full Text (HTML/PDF) |

perspectives
Timeline: The evolution of thalidomide and its IMiD derivatives as anticancer agents
J. Blake Bartlett, Keith Dredge and Angus G. Dalgleish
Nature Reviews Cancer 4, 314–322
(April 2004); doi:10.1038/nrc1323
| Abstract | Full Text (HTML / PDF) |

letter
Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome
Paul Gissen, Colin A Johnson, Neil V Morgan, Janneke M Stapelbroek, Tim Forshew, Wendy N Cooper, Patrick J McKiernan, Leo W J Klomp, Andrew A M Morris, James E Wraith, Patricia McClean, Sally A Lynch, Richard J Thompson, Bryan Lo, Oliver W Quarrell, Maja Di Rocco, Richard C Trembath, Hanna Mandel, S Wali, Fiona E Karet, A S Knisely, Roderick H J Houwen, Deirdre A Kelly and Eamonn R Maher
Nature Genetics 36, 400–404
(April 2004); doi:10.1038/ng1325
| First Paragraph | Full Text (HTML/PDF) |

review article
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
Bryan L. Roth, Douglas J. Sheffler & Wesley K. Kroeze
Nature Reviews Drug Discovery 3, 353–359
(April 2004); doi:10.1038/nrd1346
| Abstract | Full Text (HTML / PDF) |

review article
Immunotherapeutic uses of CpG oligodeoxynucleotides
Dennis M. Klinman
Nature Reviews Immunology 4, 249–259
(April 2004); doi:10.1038/nri1329
| Abstract | Full Text (HTML / PDF) |

brief communication
A receptor for green tea polyphenol EGCG
Hirofumi Tachibana, Kiyoshi Koga, Yoshinori Fujimura and Koji Yamada
Nature Structural and Molecular Biology 11, 380–381
(April 2004); doi:10.1038/nsmb743
| First Paragraph | Full Text (HTML/PDF) |

article
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Christopher L Karp, Leah M Flick, Kiwon W Park, Samir Softic, Todd M Greer, Raquel Keledjian, Rong Yang, Jasim Uddin, William B Guggino, Sowsan F Atabani, Yasmine Belkaid, Yan Xu, Jeffrey A Whitsett, Frank J Accurso, Marsha Wills-Karp and Nicos A Petasis
Nature Immunology 5, 388–392
(April 2004); doi:10.1038/ni1056
| Abstract | Full Text (HTML/PDF) |

news and views
New therapeutic key for cystic fibrosis: a role for lipoxins
Daiya Takai, Takahide Nagase and Takao Shimizu
Nature Immunology 5, 357–358
(April 2004); doi:10.1038/ni0404-357
| Full Text (HTML/PDF) |

article
A new role for Nogo as a regulator of vascular remodeling
Lisette Acevedo, Jun Yu, Hediye Erdjument-Bromage, Robert Qing Miao, Ji-Eun Kim, David Fulton, Paul Tempst, Stephen M Strittmatter and William C Sessa
Nature Medicine 10, 382–388
(April 2004); doi:10.1038/nm1020
| Abstract | Full Text (HTML/PDF) |

news and views
Nogo puts the brake on vascular lesions
Elaine W Raines
Nature Medicine 10, 348–349
(April 2004); doi:10.1038/nm0404-348
| Full Text (HTML/PDF) |

review article
The pathobiology of mucositis
Stephen T. Sonis
Nature Reviews Cancer 4, 277–284
(April 2004); doi:10.1038/nrc1318
| Abstract | Full Text (HTML / PDF) |

review article
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
Michelle R. Arkin and James A. Wells
Nature Reviews Drug Discovery 3, 301–317
(April 2004); doi:10.1038/nrd1343
| Abstract | Full Text (HTML / PDF) |

letters to nature
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry, Mark H. Soonpaa, Hans Reinecke, Hidehiro Nakajima, Hisako O. Nakajima, Michael Rubart, Kishore B. S. Pasumarthi, Jitka Ismail Virag, Stephen H. Bartelmez, Veronica Poppa, Gillian Bradford, Joshua D. Dowell, David A. Williams and Loren J. Field
Nature 428, 664–668
(08 April 2004); doi:10.1038/nature02446
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Leora B. Balsam, Amy J. Wagers, Julie L. Christensen, Theo Kofidis, Irving L. Weissman and Robert C. Robbins
Nature 428, 668–673
(08 April 2004); doi:10.1038/nature02460
| First Paragraph | Full Text (HTML / PDF) |

news and views
Stem cells: Lost in translation
Kenneth R. Chien
Nature 428, 607–608
(08 April 2004); doi:10.1038/nature02500
| Full Text (HTML / PDF) |

review article
Clinical islet transplantation: advances and immunological challenges
Camillo Ricordi and Terry B. Strom
Nature Reviews Immunology 4, 259–268
(April 2004); doi:10.1038/nri1332
| Abstract | Full Text (HTML / PDF) |

perspectives
Opinion: Rules of evidence for cancer molecular-marker discovery and validation
David F. Ransohoff
Nature Reviews Cancer 4, 309–314
(April 2004); doi:10.1038/nrc1322
| Abstract | Full Text (HTML / PDF) |

review article
Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention
Martin Braddock and Anthony Quinn
Nature Reviews Drug Discovery 3, 330–340
(April 2004); doi:10.1038/nrd1342
| Abstract | Full Text (HTML / PDF) |

review article
Designing materials for biology and medicine
Robert Langer and David A. Tirrell
Nature 428, 487–492
(01 April 2004); doi:10.1038/nature02388
| Abstract | Full Text (HTML / PDF) |

article
Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury
Deana Demjen, Stefan Klussmann, Susanne Kleber, Cecilia Zuliani, Bram Stieltjes, Corinna Metzger, Ulrich A Hirt, Henning Walczak, Werner Falk, Marco Essig, Lutz Edler, Peter H Krammer and Ana Martin-Villalba
Nature Medicine 10, 389–395
(April 2004); doi:10.1038/nm1007
| Abstract | Full Text (HTML/PDF) |

news and views
Spinal cord alive and kicking
Catherine Barthélémy and Christopher E Henderson
Nature Medicine 10, 339–340
(April 2004); doi:10.1038/nm0404-339
| Full Text (HTML/PDF) |

review article
Microtubules as a target for anticancer drugs
Mary Ann Jordan and Leslie Wilson
Nature Reviews Cancer 4, 253–265
(April 2004); doi:10.1038/nrc1317
| Abstract | Full Text (HTML / PDF) |

review article
Chemogenomics: an emerging strategy for rapid target and drug discovery
Markus Bredel and Edgar Jacoby
Nature Reviews Genetics 5, 262–275
(April 2004)
| Abstract | Full Text (HTML / PDF) |

review article
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
Neil Ruderman and Marc Prentki
Nature Reviews Drug Discovery 3, 340–351
(April 2004); doi:10.1038/nrd1344
| Abstract | Full Text (HTML / PDF) |

March

news and views
Medicine: Profile of a tumour
Olli Kallioniemi
Nature 428, 379–382
(25 March 2004); doi:10.1038/428379b
| Full Text (HTML / PDF) |

letter
A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
Hirofumi Noguchi, Masayuki Matsushita, Teru Okitsu, Akiyoshi Moriwaki, Kazuhito Tomizawa, Sunghyun Kang, Sheng-Tian Li, Naoya Kobayashi, Shinichi Matsumoto, Koich Tanaka, Noriaki Tanaka and Hideki Matsui
Nature Medicine 10, 305–309
(March 2004); doi:10.1038/nm994
| First Paragraph | Full Text (HTML/PDF) |

letters to nature
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
Hans-Guido Wendel, Elisa de Stanchina, Jordan S. Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier and Scott W. Lowe
Nature 428, 332–337
(18 March 2004); doi:10.1038/nature02369
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news and views
Cancer: Survival pathways meet their end
Frank McCormick
Nature 428, 267–269
(18 March 2004); doi:10.1038/428267a
| Full Text (HTML / PDF) |

article
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Elizabeth A Harrington, David Bebbington, Jeff Moore, Richele K Rasmussen, Abi O Ajose-Adeogun, Tomoko Nakayama, Joanne A Graham, Cecile Demur, Thierry Hercend, Anita Diu-Hercend, Michael Su, Julian M C Golec and Karen M Miller
Nature Medicine 10, 262–267
(March 2004); doi:10.1038/nm1003
| Abstract | Full Text (HTML/PDF) |

news and views
Aurora kinases dawn as cancer drug targets
Edward A Sausville
Nature Medicine 10, 234–235
(March 2004); doi:10.1038/nm0304-234
| Full Text (HTML/PDF) |

perspectives
Opinion: Cancer as a robust system: implications for anticancer therapy
Hiroaki Kitano
Nature Reviews Cancer 4, 227–235
(March 2004); doi:10.1038/nrc1300
| Abstract | Full Text (HTML / PDF) |

perspectives
Guidelines: Expression profiling — best practices for data generation and interpretation in clinical trials
The Tumor Analysis Best Practices Working Group
Nature Reviews Genetics 5, 229–237
(March 2004); doi:10.1038/nrg1297
| Abstract | Full Text (HTML / PDF) |

news and views
Turning on FLT3
Elizabeth Grzymski
Nature Structural and Molecular Biology 11, 212
(March 2004); doi:10.1038/nsmb0304-212
| Full Text (HTML/PDF) |

review article
Neurodegenerative diseases and oxidative stress
Kevin J. Barnham, Colin L. Masters and Ashley I. Bush
Nature Reviews Drug Discovery 3, 205–214
(March 2004); doi:10.1038/nrd1330
| Abstract | Full Text (HTML / PDF) |

article
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
Ronit Satchi-Fainaro, Mark Puder, John W Davies, Hai T Tran, David A Sampson, Arin K Greene, Gabriel Corfas and Judah Folkman
Nature Medicine 10, 255–261
(March 2004); doi:10.1038/nm1002
| Abstract | Full Text (HTML/PDF) |

brief communication
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-d accelerates intestinal adenoma growth
Rajnish A Gupta, Dingzhi Wang, Sharada Katkuri, Haibin Wang, Sudhansu K Dey and Raymond N DuBois
Nature Medicine 10, 245–247
(March 2004); doi:10.1038/nm993
| First Paragraph | Full Text (HTML/PDF) |

February

news and views
Turning the key on p53
David P. Lane and Peter M. Fischer
Nature 427, 789–790
(26 February 2004); doi:10.1038/427789a
| Full Text (HTML / PDF) |

article
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
Rolf Göggel, Supandi Winoto-Morbach, Gabriele Vielhaber, Yumiko Imai, Karsten Lindner, Lore Brade, Helmut Brade, Stefan Ehlers, Arthur S Slutsky, Stefan Schütze, Erich Gulbins and Stefan Uhlig
Nature Medicine 10, 155–160
(February 2004); doi:10.1038/nm977
| Abstract | Full Text (HTML/PDF) |

news and views
Ceramide lances the lungs
Peter J Barnes
Nature Medicine 10, 130–131
(February 2004); doi:10.1038/nm0204-130
| Full Text (HTML/PDF) |

article
Therapeutic effects of lysophosphatidylcholine in experimental sepsis
Ji-Jing Yan, Jun-Sub Jung, Jung-Eun Lee, Jongho Lee, Sung-Oh Huh, Hee-Sung Kim, Kyeong Cheon Jung, Jae-Young Cho, Ju-Suk Nam, Hong-Won Suh, Yung-Hi Kim and Dong-Keun Song
Nature Medicine 10, 161–167
(February 2004); doi:10.1038/nm989
| Abstract | Full Text (HTML/PDF) |

news and views
Lipid unites disparate syndromes of sepsis
Haichao Wang, Christopher J Czura and Kevin J Tracey
Nature Medicine 10, 124–125
(February 2004); doi:10.1038/nm0204-124
| Full Text (HTML/PDF) |

perspectives
Opinion: Radiation-induced bystander effects — implications for cancer
Colin B. Seymour and Carmel Mothersill
Nature Reviews Cancer 4, 158–164
(February 2004); doi:10.1038/nrc1277
| Abstract | Full Text (HTML / PDF) |

brief communication
Pathology: Cancer cells compress intratumour vessels
Timothy P. Padera, Brian R. Stoll, Jessica B. Tooredman, Diane Capen, Emmanuelle di Tomaso and Rakesh K. Jain
Nature 427, 695
(19 February 2004); doi:10.1038/427695a
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article
Priming of naive T cells inside tumors leads to eradication of established tumors
Ping Yu, Youjin Lee, Wenhua Liu, Robert K Chin, Jing Wang, Yang Wang, Andrea Schietinger, Mary Philip, Hans Schreiber and Yang-Xin Fu
Nature Immunology 5, 141–149
(February 2004); doi:10.1038/ni1029
| Abstract | Full Text (HTML/PDF) |

news and views
LIGHTing the way for tumor immunity
Alan N Houghton
Nature Immunology 5, 123–124
(February 2004); doi:10.1038/ni0204-123
| Full Text (HTML/PDF) |

letter
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma
Monique Singer, Linda D Martin, B Boris Vargaftig, Joungjoa Park, Achim D Gruber, Yuehua Li and Kenneth B Adler
Nature Medicine 10, 193–196
(February 2004); doi:10.1038/nm983
| First Paragraph | Full Text (HTML/PDF) |

article
Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
Effat S Emamian, Diana Hall, Morris J Birnbaum, Maria Karayiorgou and Joseph A Gogos
Nature Genetics 36, 131–137
(February 2004); doi:10.1038/ng1296
| Abstract | Full Text (HTML/PDF) |

news and views
Getting our AKT together in schizophrenia?
Joachim Hallmayer
Nature Genetics 36, 115–116
(February 2004); doi:10.1038/ng0204-115
| Full Text (HTML/PDF) |

perspectives
Localized striatal delivery of GDNF as a treatment for Parkinson disease
Deniz Kirik, Biljana Georgievska and Anders Björklund
Nature Neuroscience 7, 105–110
(February 2004); doi:10.1038/nn1175
| Full Text (HTML/PDF) |

review article
Oxygen therapeutics: can we tame haemoglobin?
Abdu I. Alayash
Nature Reviews Drug Discovery 3, 152–159
(February 2004); doi:10.1038/nrd1307
| Abstract | Full Text (HTML / PDF) |

article
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue, Kiyoshi Teshigawara, Shiyu Jin, Haruhisa Iguchi, Ryuji Hiramatsu, Derek LeRoith, Kiyoshi Takeda, Shizuo Akira and Masato Kasuga
Nature Medicine 10, 168–174
(February 2004); doi:10.1038/nm980
| Abstract | Full Text (HTML/PDF) |

review article
The STATs of cancer — new molecular targets come of age
Hua Yu and Richard Jove
Nature Reviews Cancer 4, 97–105
(February 2004); doi:10.1038/nrc1275
| Abstract | Full Text (HTML / PDF) |

review article
Cytokine-receptor pairing: accelerating discovery of cytokine function
Don Foster, Julia Parrish-Novak, Brian Fox and Wenfeng Xu
Nature Reviews Drug Discovery 3, 160–170
(February 2004); doi:10.1038/nrd1305
| Abstract | Full Text (HTML / PDF) |

January

review article
Dendritic cells: emerging pharmacological targets of immunosuppressive drugs
Holger Hackstein and Angus W. Thomson
Nature Reviews Immunology 4, 24–35
(January 2004); doi:10.1038/nri1256
| Abstract | Full Text (HTML / PDF) |

article
Molecular determinants of resistance to antiandrogen therapy
Charlie D Chen, Derek S Welsbie, Chris Tran, Sung Hee Baek, Randy Chen, Robert Vessella, Michael G Rosenfeld and Charles L Sawyers
Nature Medicine 10, 33–39
(January 2004); doi:10.1038/nm972
| Abstract | Full Text (HTML/PDF) |

news and views
Androgen receptor outwits prostate cancer drugs
John T Isaacs and William B Isaacs
Nature Medicine 10, 26–27
(January 2004); doi:10.1038/nm0104-26
| Full Text (HTML/PDF) |

brief communication
Modifying quinolone antibiotics yields new anxiolytics
Timothy B C Johnstone, Derk J Hogenkamp, Leanne Coyne, Jiping Su, Robert F Halliwell, Minhtam B Tran, Ryan F Yoshimura, Wen-Yen Li, Jeff Wang and Kelvin W Gee
Nature Medicine 10, 31–32
(January 2004); doi:10.1038/nm967
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review article
Mucins in cancer: protection and control of the cell surface
Michael A. Hollingsworth and Benjamin J. Swanson
Nature Reviews Cancer 4, 45–60
(January 2004); doi:10.1038/nrc1251
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article
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
Ainslie B Parsons, Renée L Brost, Huiming Ding, Zhijian Li, Chaoying Zhang, Bilal Sheikh, Grant W Brown, Patricia M Kane, Timothy R Hughes & Charles Boone
Nature Biotechnology 22, 62–69
(January 2004); doi:10.1038/nbt919
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The biological magic behind the bullets
Brent R Stockwell
Nature Biotechnology 22, 37–38
(January 2004); doi:10.1038/nbt0104-37
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article
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
Benjamin E Turk, Thiang Yian Wong, Robert Schwarzenbacher, Emily T Jarrell, Stephen H Leppla, R John Collier, Robert C Liddington and Lewis C Cantley
Nature Structural and Molecular Biology 11, 60–66
(January 2004); doi:10.1038/nsmb708
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article
Identification of small molecule inhibitors of anthrax lethal factor
Rekha G Panchal, Ann R Hermone, Tam Luong Nguyen, Thiang Yian Wong, Robert Schwarzenbacher, James Schmidt, Douglas Lane, Connor McGrath, Benjamin E Turk, James Burnett, M Javad Aman, Stephen Little, Edward A Sausville, Daniel W Zaharevitz, Lewis C Cantley, Robert C Liddington, Rick Gussio and Sina Bavari
Nature Structural and Molecular Biology 11, 67–72
(January 2004); doi:10.1038/nsmb711
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review article
Fluorescent probes for proteolysis: Tools for drug discovery
Jacques Neefjes and Nico P. Dantuma
Nature Reviews Drug Discovery 3, 58–69
(January 2004); doi:10.1038/nrd1282
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review article
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Anthony W. Norman , Mathew T. Mizwicki and Derek P. G. Norman
Nature Reviews Drug Discovery 3, 27–41
(January 2004); doi:10.1038/nrd1283
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article
Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway
Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda, Naohisa Tamura, Yoshihiro Ogawa and Kazuwa Nakao
Nature Medicine 10, 80–86
(January 2004); doi:10.1038/nm971
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Learning to take a deep breath—with BDNF
George B Richerson and John M Bekkers
Nature Medicine 10, 25–26
(January 2004); doi:10.1038/nm0104-25
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review article
The IKK NF-kB system: a treasure trove for drug development
Michael Karin, Yumi Yamamoto and Q. May Wang
Nature Reviews Drug Discovery 3, 17–26
(January 2004); doi:10.1038/nrd1279
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letters to nature
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation
Koji M. Nishiguchi, Michael A. Sandberg, Aart C. Kooijman, Kirill A. Martemyanov, Jan W. R. Pott, Stephanie A. Hagstrom, Vadim Y. Arshavsky, Eliot L. Berson and Thaddeus P. Dryja
Nature 427, 75–78
(01 January 2004); doi:10.1038/nature02170
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Vision: The need for speed
Kendall J. Blumer
Nature 427, 20–21
(01 January 2004); doi:10.1038/427020a
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article
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, Kelly Mihalic, Ying-Xin Fan, Weihua Xiao, O M Zack Howard, Ettore Appella, Andrew T Maynard and William L Farrar
Nature Medicine 10, 40–47
(January 2004); doi:10.1038/nm969
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Notch, the new muscle booster
Charlotte Schubert
Nature Medicine 10, 24
(January 2004); doi:10.1038/nm0104-24
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review article
Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling
G. Tim Bowden
Nature Reviews Cancer 4, 23–35
(January 2004); doi:10.1038/nrc1253
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