review article Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms
Mukesh K. Jain and Paul M. Ridker Nature Reviews Drug Discovery4, 977–987
(December 2005); doi:10.1038/nrd1901
| Summary | Full Text (HTML / PDF) |
article Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun and Yongfeng Shang Nature438, 981–987
(15 December 2005); doi:10.1038/nature04225
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article IKK mediates ischemia-induced neuronal death
Oliver Herrmann, Bernd Baumann, Rossana de Lorenzi, Sajjad Muhammad, Wen Zhang, Jens Kleesiek, Max Malfertheiner, Martin Köhrmann, Ioana Potrovita, Ira Maegele, Cordian Beyer, James R Burke, Mazahir T Hasan, Hermann Bujard, Thomas Wirth, Manolis Pasparakis and Markus Schwaninger Nature Medicine11, 1322–1329
(December 2005); doi:10.1038/nm1323
| Abstract | Full Text (HTML/PDF) |
letter R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis
Masanobu Komatsu and Erkki Ruoslahti Nature Medicine11, 1346–1350
(December 2005); doi:10.1038/nm1324
| First Paragraph | Full Text (HTML/PDF) |
article Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
Koichi Yoshimura, Hiroki Aoki, Yasuhiro Ikeda, Kozo Fujii, Norio Akiyama, Akira Furutani, Yoshinobu Hoshii, Nobuyuki Tanaka, Romeo Ricci, Tokuhiro Ishihara, Kensuke Esato, Kimikazu Hamano and Masunori Matsuzaki Nature Medicine11, 1330–1338
(December 2005); doi:10.1038/nm1335
| Abstract | Full Text (HTML/PDF) |
news and views Aneurysm treatments expand
Robert W Thompson Nature Medicine11, 1279–1281
(December 2005); doi:10.1038/nm1205-1279
| Full Text (HTML/PDF) |
review article Statins and cancer prevention
Marie-France Demierre , Peter D. R. Higgins , Stephen B. Gruber, Ernest Hawk and Scott M. Lippman Nature Reviews Cancer5, 930–942
(December 2005); doi:10.1038/nrc1751
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review article Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Bryan T. Hennessy, Debra L. Smith, Prahlad T. Ram, Yiling Lu and Gordon B. Mills Nature Reviews Drug Discovery4, 988–1004
(December 2005); doi:10.1038/nrd1902
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November
review article Molecular defects in T- and B-cell primary immunodeficiency diseases
Charlotte Cunningham-Rundles and Prashant P. Ponda Nature Reviews Immunology5, 880–892
(November 2005); doi:10.1038/nri1713
| Summary | Full Text (HTML / PDF) |
review article Promoting apoptosis as a strategy for cancer drug discovery
Stephen W. Fesik Nature Reviews Cancer5, 876–885
(November 2005); doi:10.1038/nrc1736
| Summary | Full Text (HTML / PDF) |
review article Mitochondrial tumour suppressors: a genetic and biochemical update
Eyal Gottlieb and Ian P. M. Tomlinson Nature Reviews Cancer5, 857–866
(November 2005); doi:10.1038/nrc1737
| Abstract | Full Text (HTML / PDF) |
October
article Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
Rei Shibata, Kaori Sato, David R Pimentel, Yukihiro Takemura, Shinji Kihara, Koji Ohashi, Tohru Funahashi, Noriyuki Ouchi and Kenneth Walsh Nature Medicine11, 1096–1103
(October 2005); doi:10.1038/nm1295
| Abstract | Full Text (HTML/PDF) |
news and views Fat, keeping the heart healthy?
Koh-ichi Yuhki, Jun-ichi Kawabe and Fumitaka Ushikubi Nature Medicine11, 1048–1049
(October 2005); doi:10.1038/nm1005-1048
| Full Text (HTML/PDF) |
article 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu and Gen Sobue Nature Medicine11, 1088–1095
(October 2005); doi:10.1038/nm1298
| Abstract | Full Text (HTML/PDF) |
article Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells
Caroline Cole, Jian Qiao, Timothy Kottke, Rosa Maria Diaz, Atique Ahmed, Luis Sanchez-Perez, Gregory Brunn, Jill Thompson, John Chester and Richard G Vile Nature Medicine11, 1073–1081
(October 2005); doi:10.1038/nm1297
| Abstract | Full Text (HTML/PDF) |
news and views Hitchhiker's guide to the T cell
Cliona M Rooney Nature Medicine11, 1051–1052
(October 2005); doi:10.1038/nm1005-1051
| Full Text (HTML/PDF) |
news and views Targeting toxic proteins for turnover
Albert R La Spada and Patrick Weydt Nature Medicine11, 1052–1053
(October 2005); doi:10.1038/nm1005-1052
| Full Text (HTML/PDF) |
article Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
Guo-Min Deng, Lixin Zheng, Francis Ka-Ming Chan and Michael Lenardo Nature Medicine11, 1066–1072
(October 2005); doi:10.1038/nm1304
| Abstract | Full Text (HTML/PDF) |
article Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
Oded Singer, Robert A Marr, Edward Rockenstein, Leslie Crews, Nicole G Coufal, Fred H Gage, Inder M Verma and Eliezer Masliah Nature Neuroscience8, 1343–1349
(October 2005); doi:10.1038/nn1531
| Abstract | Full Text (HTML/PDF) |
September
article An astrocytic basis of epilepsy
Guo-Feng Tian, Hooman Azmi, Takahiro Takano, Qiwu Xu, Weiguo Peng, Jane Lin, NancyAnn Oberheim, Nanhong Lou, Xiaohai Wang, H Ronald Zielke, Jian Kang and Maiken Nedergaard Nature Medicine11, 973–981
(September 2005); doi:10.1038/nm1277
| Abstract | Full Text (HTML/PDF) |
news and views Astrocytes get in the act in epilepsy
Michael A Rogawski Nature Medicine11, 919–920
(September 2005); doi:10.1038/nm0905-919
| Full Text (HTML/PDF) |
review article The role of autophagy in cancer development and response to therapy
Yasuko Kondo, Takao Kanzawa , Raymond Sawaya and Seiji Kondo Nature Reviews Cancer5, 726–734
(September 2005); doi:10.1038/nrc1692
| Abstract | Full Text (HTML / PDF) |
review article Can we Develop Neurally Acting Drugs for the Treatment of Migraine?
Peter J. Goadsby Nature Reviews Drug Discovery4, 741–750
(September 2005); doi:10.1038/nrd1822
| Abstract | Full Text (HTML / PDF) |
review article Pathophysiological consequences of VEGF-induced vascular permeability
Sara M. Weis and David A. Cheresh Nature437, 497–504
(22 September 2005); doi:10.1038/nature03987
| Abstract | Full Text (HTML / PDF) |
news and views Modulating autoimmunity: pick your PI3 kinase
Pamela S Ohashi and James R Woodgett Nature Medicine11, 924–925
(September 2005); doi:10.1038/nm0905-924
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article Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
Rainer Zenz, Robert Eferl, Lukas Kenner, Lore Florin, Lars Hummerich, Denis Mehic, Harald Scheuch, Peter Angel, Erwin Tschachler and Erwin F. Wagner Nature437, 369–375
(15 September 2005); doi:10.1038/nature03963
| Abstract | Full Text (HTML / PDF) |
article Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
Stephen A Back, Therese M F Tuohy, Hanqin Chen, Nicholas Wallingford, Andrew Craig, Jaime Struve, Ning Ling Luo, Fatima Banine, Ying Liu, Ansi Chang, Bruce D Trapp, Bruce F Bebo,, Jr. Mahendra S Rao and Larry S Sherman Nature Medicine11, 966–972
(September 2005); doi:10.1038/nm1279
| Abstract | Full Text (HTML/PDF) |
review article Urothelial tumorigenesis: a tale of divergent pathways
Xue-Ru Wu Nature Reviews Cancer5, 713–725
(September 2005); doi:10.1038/nrc1697
| Abstract | Full Text (HTML / PDF) |
letter The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
Wendy L Bridge, Cassandra J Vandenberg, Roger J Franklin and Kevin Hiom Nature Genetics37, 953–957
(September 2005); doi:10.1038/ng1627
| First Paragraph | Full Text (HTML/PDF) |
news and views Toward a universal multistrain bacterial vaccine
Robert G Feldman Nature Biotechnology23, 1087–1088
(September 2005); doi:10.1038/nbt0905-1087
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letter The most infectious prion protein particles
Jay R. Silveira, Gregory J. Raymond, Andrew G. Hughson, Richard E. Race, Valerie L. Sim, Stanley F. Hayes and Byron Caughey Nature437, 257–261
(08 September 2005); doi:10.1038/nature03989
| First Paragraph | Full Text (HTML / PDF) |
August
article Real-time imaging of ligand-induced IKK activation in intact cells and in living mice
Shimon Gross and David Piwnica-Worms Nature Methods2, 607–614
(August 2005); doi:10.1038/nmeth779
| Abstract | Full Text (HTML/PDF) |
article Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
YouFei Guan, Chuanming Hao, Dae Ryong Cha, Reena Rao, Wendell Lu, Donald E Kohan, Mark A Magnuson, Reyadh Redha, Yahua Zhang and Matthew D Breyer Nature Medicine11, 861–866
(August 2005); doi:10.1038/nm1278
| Abstract | Full Text (HTML/PDF) |
news and views TZDs and diabetes: testing the waters
Clay F Semenkovich Nature Medicine11, 822–824
(August 2005); doi:10.1038/nm0805-822
| Full Text (HTML/PDF) |
research article High-throughput generation of small antibacterial peptides with improved activity
Kai Hilpert, Rudolf Volkmer-Engert, Tess Walter and Robert E W Hancock Nature Biotechnology23, 1008–1012
(August 2005); doi:10.1038/nbt1113
| First Paragraph | Full Text (HTML/PDF) |
letter Dystrophic heart failure blocked by membrane sealant poloxamer
Soichiro Yasuda, DeWayne Townsend, Daniel E. Michele, Elizabeth G. Favre, Sharlene M. Day and Joseph M. Metzger Nature436, 1025–1029
(18 August 2005); doi:10.1038/nature03844
| First Paragraph | Full Text (HTML / PDF) |
news and views Cardiology: Rips repaired
Richard A. Steinhardt Nature436, 925
(18 August 2005); doi:10.1038/436925a
| Full Text (HTML / PDF) |
insight Unravelling hepatitis C virus replication from genome to function
Brett D. Lindenbach and Charles M. Rice Nature436, 933–938
(18 August 2005); doi:10.1038/nature04077
| Abstract | Full Text (HTML / PDF) |
insight Evasion of intracellular host defence by hepatitis C virus
Michael Gale Jr and Eileen M. Foy Nature436, 939–945
(18 August 2005); doi:10.1038/nature04078
| Abstract | Full Text (HTML / PDF) |
insight Mechanism of action of interferon and ribavirin in treatment of hepatitis C
Jordan J. Feld and Jay H. Hoofnagle Nature436, 967–972
(18 August 2005); doi:10.1038/nature04082
| Abstract | Full Text (HTML / PDF) |
review article Interleukin-1 and neuronal injury
Stuart M. Allan, Pippa J. Tyrrell and Nancy J. Rothwell Nature Reviews Immunology5, 629–640
(August 2005); doi:10.1038/nri1664
| Abstract | Full Text (HTML / PDF) |
brief communication Colorectal cancer: Mutations in a signalling pathway
D. Williams Parsons, Tian-Li Wang, Yardena Samuels, Alberto Bardelli, Jordan M. Cummins, Laura DeLong, Natalie Silliman, Janine Ptak, Steve Szabo, James K. V. Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer and Victor E. Velculescu Nature436, 792
(11 August 2005); doi:10.1038/436792a
| First Paragraph | Full Text (HTML / PDF) |
letter A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
Keiji Kuba, Yumiko Imai, Shuan Rao, Hong Gao, Feng Guo, Bin Guan, Yi Huan, Peng Yang, Yanli Zhang, Wei Deng, Linlin Bao, Binlin Zhang, Guang Liu, Zhong Wang, Mark Chappell, Yanxin Liu, Dexian Zheng, Andreas Leibbrandt, Teiji Wada, Arthur S Slutsky, Depei Liu, Chuan Qin, Chengyu Jiang and Josef M Penninger Nature Medicine11, 875–879
(August 2005); doi:10.1038/nm1267
| First Paragraph | Full Text (HTML/PDF) |
news and views Good ACE, bad ACE do battle in lung injury, SARS
John Nicholls and Malik Peiris Nature Medicine11, 821–822
(August 2005); doi:10.1038/nm0805-821
| Full Text (HTML/PDF) |
review article Leukotriene modifiers as potential therapeutics for cardiovascular disease
Colin D. Funk Nature Reviews Drug Discovery4, 664–672
(August 2005); doi:10.1038/nrd1796
| Abstract | Full Text (HTML / PDF) |
July
article Genes that mediate breast cancer metastasis to lung
Andy J. Minn , Gaorav P. Gupta, Peter M. Siegel, Paula D. Bos, Weiping Shu, Dilip D. Giri, Agnes Viale, Adam B. Olshen, William L. Gerald and Joan Massagué Nature436, 518–524
(28 July 2005); doi:10.1038/nature03799
| Abstract | Full Text (HTML / PDF) |
news and views Cancer: One step at a time
David Mooney Nature436, 468–469
(28 July 2005); doi:10.1038/436468a
| Full Text (HTML / PDF) |
review article Neurosteroids: endogenous regulators of the GABAA receptor
Delia Belelli and Jeremy J. Lambert Nature Reviews Neuroscience6, 565–575
(July 2005); doi:10.1038/nrn1703
| Abstract | Full Text (HTML / PDF) |
review article Design and development of polymers for gene delivery
Daniel W. Pack, Allan S. Hoffman, Suzie Pun and Patrick S. Stayton Nature Reviews Drug Discovery4, 581–593
(July 2005); doi:10.1038/nrd1775
| Abstract | Full Text (HTML / PDF) |
letter EphrinB2 is the entry receptor
for Nipah virus, an emergent deadly paramyxovirus Oscar A. Negrete,
Ernest L. Levroney, Hector C. Aguilar, Andrea Bertolotti-Ciarlet, Ronen
Nazarian, Sara Tajyar and Benhur Lee Nature436,
401–405 (21 July 2005); doi:10.1038/nature03838 | First Paragraph |
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PDF) |
review
article Caspase-independent cell death Guido Kroemer and
Seamus J Martin Nature Medicine11, 725–730 (July 2005);
doi:10.1038/nm1263 | Abstract | Full Text (HTML/PDF)
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review article The anaemia of
cancer: death by a thousand cuts Jerry L. Spivak Nature Reviews
Cancer5, 543–555 (July 2005); doi:10.1038/nrc1648 | Abstract | Full Text (HTML /
PDF) |
article Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
Patrick M Reeves, Bettina Bommarius, Sarah Lebeis, Shannon McNulty, Jens Christensen, Alyson Swimm, Ann Chahroudi, Rahul Chavan, Mark B Feinberg, Darren Veach, William Bornmann, Melanie Sherman and Daniel Kalman Nature Medicine11, 731–739
(July 2005); doi:10.1038/nm1265
| Abstract | Full Text (HTML/PDF) |
news and views Gleevec casts a pox on poxviruses
Grant McFadden Nature Medicine11, 711–712
(July 2005); doi:10.1038/nm0705-711
| Full Text (HTML/PDF) |
review article The role of focal-adhesion kinase in cancer — a new therapeutic opportunity
Gordon W. McLean, Neil O. Carragher, Egle Avizienyte, Jeff Evans, Valerie G. Brunton and Margaret C. Frame Nature Reviews Cancer5, 505–515
(July 2005); doi:10.1038/nrc1647
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review article Ageing and metabolism: drug discovery opportunities
Rory Curtis, Bard J. Geesaman and Peter S. DiStefano Nature Reviews Drug Discovery AOP published online 24 June 2005; doi:10.1038/nrd1777
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letter Angiotensin-converting enzyme 2 protects from severe acute lung failure
Yumiko Imai, Keiji Kuba, Shuan Rao, Yi Huan, Feng Guo, Bin Guan, Peng Yang, Renu Sarao, Teiji Wada, Howard Leong-Poi, Michael A. Crackower, Akiyoshi Fukamizu, Chi-Chung Hui, Lutz Hein, Stefan Uhlig, Arthur S. Slutsky, Chengyu Jiang and Josef M. Penninger Nature436, 112–116
(07 July 2005); doi:10.1038/nature03712
| First Paragraph | Full Text (HTML / PDF) |
June
article Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
Roberto Chiarle, William J Simmons, Honjying Cai, Girish Dhall, Alberto Zamo, Regina Raz, James G Karras, David E Levy and Giorgio Inghirami Nature Medicine11, 623–629
(June 2005); doi:10.1038/nm1249
| Abstract | Full Text (HTML/PDF) |
news and views Validating Stat3 in cancer therapy
James E Darnell Jr Nature Medicine11, 595–596
(June 2005); doi:10.1038/nm0605-595
| Full Text (HTML/PDF) |
review article Disrupting tumour blood vessels
Gillian M. Tozer, Chryso Kanthou and Bruce C. Baguley Nature Reviews Cancer5, 423–435
(June 2005); doi:10.1038/nrc1628
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review article Glycans in cancer and inflammation — potential for therapeutics and diagnostics
Danielle H. Dube and Carolyn R. Bertozzi Nature Reviews Drug Discovery4, 477–488
(June 2005); doi:10.1038/nrd1751
| Summary | Full Text (HTML / PDF) |
letter An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Tilman Oltersdorf , Steven W. Elmore , Alexander R. Shoemaker , Robert C. Armstrong , David J. Augeri , Barbara A. Belli , Milan Bruncko , Thomas L. Deckwerth , Jurgen Dinges , Philip J. Hajduk , Mary K. Joseph , Shinichi Kitada , Stanley J. Korsmeyer , Aaron R. Kunzer , Anthony Letai , Chi Li , Michael J. Mitten , David G. Nettesheim , ShiChung Ng , Paul M. Nimmer , Jacqueline M. O'Connor , Anatol Oleksijew , Andrew M. Petros , John C. Reed , Wang Shen , Stephen K. Tahir , Craig B. Thompson , Kevin J. Tomaselli , Baole Wang , Michael D. Wendt , Haichao Zhang , Stephen W. Fesik and Saul H. Rosenberg Nature435, 677–681
(02 June 2005); doi:10.1038/nature03579
| First Paragraph | Full Text (HTML / PDF) |
article Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
Jeffrey P. MacKeigan, Leon O. Murphy and John Blenis Nature Cell Biology7, 591–600
(June 2005); doi:10.1038/ncb1258
| Abstract | Full Text (HTML/PDF) |
May
review article ERBB receptors and cancer: the complexity of targeted inhibitors
Nancy E. Hynes and Heidi A. Lane Nature Reviews Cancer5, 341–354
(May 2005); doi:10.1038/nrc1609
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review article Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
Prakash Jagtap and Csaba Szabó Nature Reviews Drug Discovery4, 421–440
(May 2005); doi:10.1038/nrd1718
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news and views Do-all receptor takes on coagulation, inflammation
Charles Esmon Nature Medicine11, 475–477
(May 2005); doi:10.1038/nm0505-475
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article Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
Alan Lau, Karra M. Swinbank, Parvin S. Ahmed, Debra L. Taylor, Stephen P. Jackson, Graeme C. M. Smith and Mark J. O'Connor Nature Cell Biology7, 493–500
(May 2005); doi:10.1038/ncb1250
| Abstract | Full Text (HTML/PDF) |
news and views ATM: HIV-1's Achilles heel?
René Daniel and Roger J. Pomerantz Nature Cell Biology7, 452–453
(May 2005); doi:10.1038/ncb0505-452
| Full Text (HTML/PDF) |
article Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
Irina Petrache, Viswanathan Natarajan, Lijie Zhen, Terry R Medler, Amy T Richter, Chung Cho, Walter C Hubbard, Evgeny V Berdyshev and Rubin M Tuder Nature Medicine11, 491–498
(June 2005); doi:10.1038/nm1238
| Abstract | Full Text (HTML/PDF) |
news and views Lipid let loose in pulmonary emphysema
Jack A Elias and Chun Geun Lee Nature Medicine11, 471–472
(May 2005); doi:10.1038/nm0505-471
| Full Text (HTML/PDF) |
review article From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Claudia Bagni and William T. Greenough Nature Reviews Neuroscience6, 376–387
(May 2005); doi:10.1038/nrn1667
| Summary | Full Text (HTML / PDF) |
review article Rho kinase, a promising drug target for neurological disorders
Bernhard K. Mueller, Helmut Mack and Nicole Teusch Nature Reviews Drug Discovery4, 387–398
(May 2005); doi:10.1038/nrd1719
| Summary | Full Text (HTML / PDF) |
April
letters to nature A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James, Valérie Ugo, Jean-Pierre Le Couédic, Judith Staerk, François Delhommeau, Catherine Lacout, Loïc Garçon, Hana Raslova, Roland Berger, Annelise Bennaceur-Griscelli, Jean Luc Villeval, Stefan N.Constantinescu, Nicole Casadevall and William Vainchenker Nature434, 1144–1148
(28 April 2005); doi:10.1038/nature03546
| First Paragraph | Full Text (HTML / PDF) |
review article Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
Chikashi Nakanishi and Masakazu Toi Nature Reviews Cancer5, 297–309
(April 2005); doi:10.1038/nrc1588
| Summary | Full Text (HTML / PDF) |
review article Model organisms: Chemistry-to-gene screens in Caenorhabditis elegans
Andrew K. Jones, Steven D. Buckingham and David B. Sattelle Nature Reviews Drug Discovery4, 321–330
(April 2005); doi:10.1038/nrd1692
| Summary | Full Text (HTML / PDF) |
review article Heat-shock proteins induce T-cell regulation of chronic inflammation
Willem van Eden, Ruurd van der Zee and Berent Prakken Nature Reviews Immunology5, 318–330
(April 2005); doi:10.1038/nri1593
| Summary | Full Text (HTML / PDF) |
review article Immunosuppressive networks in the tumour environment and their therapeutic relevance
Weiping Zou Nature Reviews Cancer5, 263–274
(April 2005); doi:10.1038/nrc1586
| Summary | Full Text (HTML / PDF) |
review article Cellular processing of platinum anticancer drugs
Dong Wang and Stephen J. Lippard Nature Reviews Drug Discovery4, 307–320
(April 2005); doi:10.1038/nrd1691
| Summary | Full Text (HTML / PDF) |
letters to nature Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant, Niklas Schultz, Huw D. Thomas, Kayan M. Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J. Curtin and Thomas Helleday Nature434, 913–917
(14 April 2005); doi:10.1038/nature03443
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Hannah Farmer , Nuala McCabe , Christopher J. Lord, Andrew N. J. Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M. B. Martin, Stephen P. Jackson, Graeme C. M. Smith and Alan Ashworth Nature434, 917–921
(14 April 2005); doi:10.1038/nature03445
| First Paragraph | Full Text (HTML / PDF) |
review article Dendritic cells as therapeutic vaccines against cancer
Jacques Banchereau and A. Karolina Palucka Nature Reviews Immunology5, 296–306
(April 2005); doi:10.1038/nri1592
| Summary | Full Text (HTML / PDF) |
review article High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Michael T. Lotze and Kevin J. Tracey Nature Reviews Immunology5, 331–342
(April 2005); doi:10.1038/nri1594
| Summary | Full Text (HTML / PDF) |
article Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
Jingmei Lin, Sanjeevkumar R Patel, Xu Cheng, Eun Ah Cho, Inna Levitan, Matthew Ullenbruch, Sem H Phan, John M Park and Gregory R Dressler Nature Medicine11, 387–393
(April 2005); doi:10.1038/nm1217
| Abstract | Full Text (HTML/PDF) |
news and views Setting a trap for tissue fibrosis
Eric G Neilson Nature Medicine11, 373–374
(April 2005); doi:10.1038/nm0405-373
| Full Text (HTML/PDF) |
article Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
Beth A Firulli, Dayana Krawchuk, Victoria E Centonze, Neil Vargesson, David M Virshup, Simon J Conway, Peter Cserjesi, Ed Laufer and Anthony B Firulli Nature Genetics37, 373–381
(April 2005); doi:10.1038/ng1525
| Abstract | Full Text (HTML/PDF) |
review article Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
C. M. Hawrylowicz and A. O'Garra Nature Reviews Immunology5, 271–283
(2005); doi:10.1038/nri1589
| Summary | Full Text (HTML / PDF) |
letter A chimeric human-cat fusion protein blocks cat-induced allergy
Daocheng Zhu, Christopher L Kepley, Ke Zhang, Tetsuya Terada, Takechiyo Yamada and Andrew Saxon Nature Medicine11, 446–449
(April 2005); doi:10.1038/nm1219
| First Paragraph | Full Text (HTML/PDF) |
news and views Nipping cat allergy with fusion proteins
Janet Kalesnikoff and Stephen J Galli Nature Medicine11, 381–382
(April 2005); doi:10.1038/nm0405-381
| Full Text (HTML/PDF) |
letter Regulation of NKT cell development by SAP, the protein defective in XLP
Kim E Nichols, Jamie Hom, Shun-You Gong, Arupa Ganguly, Cindy S Ma, Jennifer L Cannons, Stuart G Tangye, Pamela L Schwartzberg, Gary A Koretzky and Paul L Stein Nature Medicine11, 340–345
(March 2005); doi:10.1038/nm1189
| First Paragraph | Full Text (HTML/PDF) |
news and views The need for natural killer T cells
H Robson MacDonald and Jens Schümann Nature Medicine11, 256–257
(March 2005); doi:10.1038/nm0305-256
| Full Text (HTML/PDF) |
brief communication Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome
Irene A Aligianis, Colin A Johnson, Paul Gissen, Dongrong Chen, Daniel Hampshire, Katrin Hoffmann, Esther N Maina, Neil V Morgan, Louise Tee, Jenny Morton, John R Ainsworth, Denise Horn, Elisabeth Rosser, Trevor R P Cole, Irene Stolte-Dijkstra, Karen Fieggen, Jill Clayton-Smith, André Mégarbané, Julian P Shield, Ruth Newbury-Ecob, William B Dobyns, John M Graham, Jr Klaus W Kjaer, Mette Warburg, Jacqueline Bond, Richard C Trembath, Laura W Harris, Yoshimi Takai, Stefan Mundlos, David Tannahill, C Geoffery Woods and Eamonn R Maher Nature Genetics37, 221–224
(March 2005); doi:10.1038/ng1517
| First Paragraph | Full Text (HTML/PDF) |
research article A small molecule-kinase interaction map for clinical kinase inhibitors
Miles A Fabian, William H Biggs, III Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar and David J Lockhart Nature Biotechnology23, 329–336
(March 2005); doi:10.1038/nbt1068
| Abstract | Full Text (HTML/PDF) |
news and views Interaction maps for kinase inhibitors
James D Griffin Nature Biotechnology23, 308–309
(March 2005); doi:10.1038/nbt0305-308
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March
article Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
Alexander J Muller, James B DuHadaway, P Scott Donover, Erika Sutanto-Ward and George C Prendergast Nature Medicine11, 312–319
(March 2005); doi:10.1038/nm1196
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review article Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
Ruibao Ren Nature Reviews Cancer5, 172–183
(March 2005); doi:10.1038/nrc1567
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review article Poxvirus tropism
Grant McFadden Nature Reviews Microbiology3, 201–213
(March 2005); doi:10.1038/nrmicro1099
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review article MHC class I molecules and kirs in human history, health and survival
Peter Parham Nature Reviews Immunology AOP published online 18 February 2005; doi:10.1038/nri1570
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article Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
Hiromu Ito, Mette Koefoed, Prarop Tiyapatanaputi, Kirill Gromov, J Jeffrey Goater, Jonathan Carmouche, Xinping Zhang, Paul T Rubery, Joseph Rabinowitz, R Jude Samulski, Takashi Nakamura, Kjeld Soballe, Regis J O'Keefe, Brendan F Boyce and Edward M Schwarz Nature Medicine11, 291–297
(March 2005); doi:10.1038/nm1190
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letter Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin
Edgar A Otto, Bart Loeys, Hemant Khanna, Jan Hellemans, Ralf Sudbrak, Shuling Fan, Ulla Muerb, John F O'Toole, Juliana Helou, Massimo Attanasio, Boris Utsch, John A Sayer, Concepcion Lillo, David Jimeno, Paul Coucke, Anne De Paepe, Richard Reinhardt, Sven Klages, Motoyuki Tsuda, Isao Kawakami, Takehiro Kusakabe, Heymut Omran, Anita Imm, Melissa Tippens, Pamela A Raymond, Jo Hill, Phil Beales, Shirley He, Andreas Kispert, Benjamin Margolis, David S Williams, Anand Swaroop and Friedhelm Hildebrandt Nature Genetics37, 282–288
(March 2005); doi:10.1038/ng1520
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review article HDL as a target in the treatment of atherosclerotic cardiovascular disease
Patrick Linsel-Nitschke and Alan R. Tall Nature Reviews Drug Discovery4, 193–205
(March 2005); doi:10.1038/nrd1658
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article Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
Timothy S Gomez, Michael J Hamann, Sean McCarney, Doris N Savoy, Casey M Lubking, Michael P Heldebrant, Christine M Labno, David J McKean, Mark A McNiven, Janis K Burkhardt and Daniel D Billadeau Nature Immunology6, 261–270
(March 2005); doi:10.1038/ni1168
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article Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
Melanie Greter, Frank L Heppner, Maria P Lemos, Bernhard M Odermatt, Norbert Goebels, Terri Laufer, Randolph J Noelle and Burkhard Becher Nature Medicine11, 328–334
(March 2005); doi:10.1038/nm1197
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letter Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
Eileen J McMahon, Samantha L Bailey, Carol Vanderlugt Castenada, Hanspeter Waldner and Stephen D Miller Nature Medicine11, 335–339
(March 2005); doi:10.1038/nm1202
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news and views Multiple sclerosis: trapped in deadly glue
Michael Platten and Lawrence Steinman Nature Medicine11, 252–253
(March 2005); doi:10.1038/nm0305-252
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letter A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Bart L Loeys, Junji Chen, Enid R Neptune, Daniel P Judge, Megan Podowski, Tammy Holm, Jennifer Meyers, Carmen C Leitch, Nicholas Katsanis, Neda Sharifi, F Lauren Xu, Loretha A Myers, Philip J Spevak, Duke E Cameron, Julie De Backer, Jan Hellemans, Yan Chen, Elaine C Davis, Catherine L Webb, Wolfram Kress, Paul Coucke, Daniel B Rifkin, Anne M De Paepe and Harry C Dietz Nature Genetics37, 275–281
(March 2005); doi:10.1038/ng1511
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review article The centrosome in human genetic disease
Jose L. Badano, Tanya M. Teslovich and Nicholas Katsanis Nature Reviews Genetics6, 194–205
(March 2005); doi:10.1038/nrg1557
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review article Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Kim A. Brogden Nature Reviews Microbiology3, 238–250
(March 2005); doi:10.1038/nrmicro1098
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February
review article The multifarious, multireplicon burkholderia cepacia complex
Eshwar Mahenthiralingam, Teresa A. Urban and Joanna B. Goldberg Nature Reviews Microbiology3, 144–156
(February 2005); doi:10.1038/nrmicro1085
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article Cathepsin L is required for endothelial progenitor cell-induced neovascularization
Carmen Urbich, Christopher Heeschen, Alexandra Aicher, Ken-ichiro Sasaki, Thomas Bruhl, Mohammad R Farhadi, Peter Vajkoczy, Wolf K Hofmann, Christoph Peters, Len A Pennacchio, Nasreddin D Abolmaali, Emmanouil Chavakis, Thomas Reinheckel, Andreas M Zeiher and Stefanie Dimmeler Nature Medicine11, 206–213
(February 2005); doi:10.1038/nm1182
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article Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang and David A Kass Nature Medicine11, 214–222
(February 2005); doi:10.1038/nm1175
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news and views Viagra: now mending hearts
Michael E Mendelsohn Nature Medicine11, 115–116
(February 2005); doi:10.1038/nm0205-115
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letter Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor
Vera Jankowski, Markus Tölle, Raymond Vanholder, Gilbert Schönfelder, Markus van der Giet, Lars Henning, Hartmut Schlüter, Martin Paul, Walter Zidek and Joachim Jankowski Nature Medicine11, 223–227
(February 2005); doi:10.1038/nm1188
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article An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis
Hideki Kizawa, Ikuyo Kou, Aritoshi Iida, Akihiro Sudo, Yoshinari Miyamoto, Akira Fukuda, Akihiko Mabuchi, Akihiro Kotani, Akira Kawakami, Seizo Yamamoto, Atsumasa Uchida, Kozo Nakamura, Kohei Notoya, Yusuke Nakamura and Shiro Ikegawa Nature Genetics37, 138–144
(February 2005); doi:10.1038/ng1496
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review article GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Kent L. Rossman , Channing J. Der and John Sondek Nature Reviews Molecular Cell Biology6, 167–180
(February 2005); doi:10.1038/nrm1587
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article Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo
Brent A Hanks, Jianghong Jiang, Rana A K Singh, Weitao Song, Michael Barry, Mary H Huls, Kevin M Slawin and David M Spencer Nature Medicine11, 130–137
(February 2005); doi:10.1038/nm1183
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article Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi and Junji Takeda Nature Medicine11, 160–166
(February 2005); doi:10.1038/nm1179
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news and views ACE sets up fertilization
Pierre Corvol Nature Medicine11, 118–119
(February 2005); doi:10.1038/nm0205-118
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review article Bleomycins: towards better therapeutics
Jingyang Chen and JoAnne Stubbe Nature Reviews Cancer5, 102–112
(February 2005); doi:10.1038/nrc1547
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research article A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
Graeme L Card, Landy Blasdel, Bruce P England, Chao Zhang, Yoshihisa Suzuki, Sam Gillette, Daniel Fong, Prabha N Ibrahim, Dean R Artis, Gideon Bollag, Michael V Milburn, Sung-Hou Kim, Joseph Schlessinger and Kam Y J Zhang Nature Biotechnology23, 201–207
(February 2005); doi:10.1038/nbt1059
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review article Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn and Darryle D. Schoepp Nature Reviews Drug Discovery4, 131–144
(February 2005); doi:10.1038/nrd1630
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review article The humanization of N-glycosylation pathways in yeast
Stefan Wildt and Tilllman U. Gerngross Nature Reviews Microbiology3, 119–128
(February 2005); doi:10.1038/nrmicro1087
| Abstract | Full Text (HTML / PDF) |
perspectives Innovation: Control of DNA replication and its potential clinical exploitation
Michael A. Gonzalez, Kiku-e K. Tachibana, Ronald A. Laskey and Nicholas Coleman Nature Reviews Cancer AOP published online 20 January 2005; doi:10.1038/nrc1548
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review article The histamine H3 receptor: from gene cloning to H3 receptor drugs
Rob Leurs, Remko A. Bakker, Henk Timmerman and Iwan J. P. de Esch Nature Reviews Drug Discovery AOP published online 24 January 2005; doi:10.1038/nrd1631
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January
review article α-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles
Luc Van Kaer Nature Reviews Immunology5, 31–42
(January 2005); doi:10.1038/nri1531
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review article The nuclear lamina comes of age
Yosef Gruenbaum, Ayelet Margalit, Robert D. Goldman, Dale K. Shumaker and Katherine L. Wilson Nature Reviews Molecular Cell Biology6, 21–31
(January 2005); doi:10.1038/nrm1550
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article Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
Shigetoshi Sano, Keith Syson Chan, Steve Carbajal, John Clifford, Mary Peavey, Kaoru Kiguchi, Satoshi Itami, Brian J Nickoloff and John DiGiovanni Nature Medicine11, 43–49
(January 2005); doi:10.1038/nm1162
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news and views Psoriasis: more than skin deep
Mark R Pittelkow Nature Medicine11, 17–18
(January 2005); doi:10.1038/nm0105-17
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letter Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
Micah T McClain, Latisha D Heinlen, Gregory J Dennis, Jon Roebuck, John B Harley and Judith A James Nature Medicine11, 85–89
(January 2005); doi:10.1038/nm1167
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research article Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells
Marie-Catherine Giarratana, Ladan Kobari, Hélène Lapillonne, David Chalmers, Laurent Kiger, Thérèse Cynober, Michael C Marden, Henri Wajcman and Luc Douay Nature Biotechnology23, 69–74
(January 2005); doi:10.1038/nbt1047
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news and views Banking on red blood cells
Narla Mohandas Nature Biotechnology23, 35–36
(January 2005); doi:10.1038/nbt0105-35
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review article Data integration: challenges for drug discovery
David B. Searls Nature Reviews Drug Discovery4, 45–58
(January 2005); doi:10.1038/nrd1608
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letters to nature β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Jeffrey D. Rothstein, Sarjubhai Patel, Melissa R. Regan, Christine Haenggeli, Yanhua H. Huang, Dwight E. Bergles, Lin Jin, Margaret Dykes Hoberg, Svetlana Vidensky, Dorothy S. Chung, Shuy Vang Toan, Lucie I. Bruijn, Zao-zhong Su, Pankaj Gupta and Paul B. Fisher Nature433, 73–77
(06 January 2005); doi:10.1038/nature03180
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article Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
Regine Gläser, Jürgen Harder, Hans Lange, Joachim Bartels, Enno Christophers and Jens-Michael Schröder Nature Immunology6, 57–64
(January 2005); doi:10.1038/ni1142
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news and views An important clue: fingerprints point to psoriasin in defense against E. coli
Charles L Bevins Nature Immunology6, 12–13
(January 2005); doi:10.1038/ni0105-12
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review article The neuropathogenesis of AIDS
Francisco González-Scarano and Julio Martín-García Nature Reviews Immunology5, 69–81
(January 2005); doi:10.1038/nri1527
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review article Osteoblasts in prostate cancer metastasis to bone
Christopher J. Logothetis and Sue-Hwa Lin Nature Reviews Cancer5, 21–28
(January 2005); doi:10.1038/nrc1528
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review article Modulation of neurodegeneration by molecular chaperones
Paul J. Muchowski and Jennifer L. Wacker Nature Reviews Neuroscience6, 11–22
(January 2005); doi:10.1038/nrn1587
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review article Psoriasis: emerging therapeutic strategies
Alice B. Gottlieb Nature Reviews Drug Discovery4, 19–34
(January 2005); doi:10.1038/nrd1607
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