article 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
Nicole C Kaneider et al. Nature Immunology8, 1303–1312
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article T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
Matthias T Stephan et al. Nature Medicine13, 1440–1449
(December 2007); doi:10.1038/nm1676
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news and views Building the bionic T cell
Drew M Pardoll Nature Medicine13, 1411–1413
(December 2007); doi:10.1038/nm1207-1411
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letter Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
Manuel A Friese et al. Nature Medicine13, 1483–1489
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scientific report Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein
Ryosuke Usui, Masabumi Shibuya, Shun Ishibashi & Yoshiro Maru EMBO Reports8, 1155–1161
(December 2007); doi:10.1038/sj.embor.7401103
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article Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
Tuomas Tammela et al. Nature Medicine13, 1458–1466
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letter PPAR-γ regulates osteoclastogenesis in mice
Yihong Wan, Ling-Wa Chong & Ronald M Evans Nature Medicine13, 1496–1503
(December 2007); doi:10.1038/nm1672
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review Interferons at age 50: past, current and future impact on biomedicine
Ernest C. Borden et al. Nature Reviews Drug Discovery6, 975–990
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November
letter Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al. Nature450, 712–716
(29 November 2007); doi:10.1038/nature06261
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article TLR4 enhances TGF-β signaling and hepatic fibrosis
Ekihiro Seki et al. Nature Medicine13, 1324–1332
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news and views A deer in the headlights: BAMBI meets liver fibrosis
Scott L Friedman Nature Medicine13, 1281–1282
(November 2007); doi:10.1038/nm1107-1281
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review Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Nicholas A. Bishop & Leonard Guarente Nature Reviews Genetics8, 835–844
(November 2007); doi:10.1038/nrg2188
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review Complement-targeted therapeutics
Daniel Ricklin & John D Lambris Nature Biotechnology25, 1265–1275
(November 2007); doi:10.1038/nbt1342
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perspective Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
Russell P Rother, Scott A Rollins, Christopher F Mojcik, Robert A Brodsky & Leonard Bell Nature Biotechnology25, 1256–1264
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article Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease
Markus Weckmann et al. Nature Medicine13, 1308–1315
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letter Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Sandip Ray et al. Nature Medicine13, 1359–1362
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article Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
Chengbin Wu et al. Nature Biotechnology25, 1290–1297
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news and views Two heads are better than one
Sherie L Morrison Nature Biotechnology25, 1233–1234
(November 2007); doi:10.1038/nbt1107-1233
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review Target deconvolution strategies in drug discovery
Georg C. Terstappen, Christina Schlüpen, Roberto Raggiaschi & Giovanni Gaviraghi Nature Reviews Drug Discovery6, 891–903
(November 2007); doi:10.1038/nrd2410
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article prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast
Kum-Loong Boon et al. Nature Structural & Molecular Biology14, 1077–1083
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review When cilia go bad: cilia defects and ciliopathies
Manfred Fliegauf, Thomas Benzing & Heymut Omran Nature Reviews Molecular Cell Biology8, 880–893
(November 2007); doi:10.1038/nrm2278
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perspective Proteins, drug targets and the mechanisms they control: the simple truth about complex networks
Robyn P. Araujo, Lance A. Liotta & Emanuel F. Petricoin Nature Reviews Drug Discovery6, 871–880
(November 2007); doi:10.1038/nrd2381
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October
letter Central control of bone remodeling by neuromedin U
Shingo Sato et al. Nature Medicine13, 1234–1240
(October 2007); doi:10.1038/nm1640
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news and views Where lies the blame for resistance-tumor or host?
Charles L Sawyers Nature Medicine13, 1144–1145
(October 2007); doi:10.1038/nm1007-1144
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review Flying under the radar: the new wave of BCR-ABL inhibitors
Alfonso Quintás-Cardama, Hagop Kantarjian & Jorge Cortes Nature Reviews Drug Discovery6, 834–848
(October 2007); doi:10.1038/nrd2324
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review Mammalian circadian signaling networks and therapeutic targets
Andrew C Liu, Warren G Lewis and Steve A Kay Nature Chemical Biology3, 630–639
(October 2007); doi:10.1038/nchembio.2007.37
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article 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
Michihisa Umetani et al. Nature Medicine13, 1185–1192
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review Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer
David R. Clemmons Nature Reviews Drug Discovery6, 821–833
(October 2007); doi:10.1038/nrd2359
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news and views It's what you do with the fat that matters!
Clinton R Bruce & Mark A Febbraio Nature Medicine13, 1137–1138
(October 2007); doi:10.1038/nm1007-1137
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review Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
Weidong Wang Nature Reviews Genetics8, 735–748
(October 2007); doi:10.1038/nrg2159
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letter Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
Alexander M. Binshtok, Bruce P. Bean & Clifford J. Woolf Nature449, 607–610
(4 October 2007); doi:10.1038/nature06191
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news and views Neuroscience: A local route to pain relief
Edwin W. McCleskey Nature449, 545–546
(4 October 2007); doi:10.1038/449545a
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review Evolving functions of endothelial cells in inflammation
Jordan S. Pober & William C. Sessa Nature Reviews Immunology7, 803–815
(October 2007); doi:10.1038/nri2171
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perspective Pathologically activated therapeutics for neuroprotection
Stuart A. Lipton Nature Reviews Neuroscience8, 803–808
(October 2007); doi:10.1038/nrn2229
| Summary | Full Text (HTML / PDF) |
September
review Multiple sclerosis: a complicated picture of autoimmunity
Henry F McFarland & Roland Martin Nature Immunology8, 913–919
(September 2007); doi:10.1038/ni1507
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review Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
Stephen D. Miller, Danielle M. Turley & Joseph R. Podojil Nature Reviews Immunology7, 665–677
(September 2007); doi:10.1038/nri2153
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letter High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Toshihiko Tanno, Natarajan V Bhanu, Patricia A Oneal, Sung-Ho Goh, Pamela Staker, Y Terry Lee, John W Moroney, Christopher H Reed, Naomi LC Luban, Rui-Hong Wang, Thomas E Eling, Richard Childs, Tomas Ganz, Susan F Leitman, Suthat Fucharoen & Jeffery L Miller Nature Medicine13, 1096–1101
(September 2007); doi:10.1038/nm1629
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news and views Diseased red blood cells topple iron balance
Stella T Chou & Mitchell J Weiss Nature Medicine13, 1020–1021
(September 2007); doi:10.1038/nm0907-1020
| Summary | Full Text (HTML / PDF) |
letter Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Boris V Andreev, Alla S Avedisova, Leonid M Bardenstein, Issak Y Gurovich, Margarita A Morozova, Sergey N Mosolov, Nikolai G Neznanov, Alexander M Reznik, Anatoly B Smulevich, Vladimir A Tochilov, Bryan G Johnson, James A Monn & Darryle D Schoepp Nature Medicine13, 1102–1107
(September 2007); doi:10.1038/nm1632
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news and views Schizophrenia drug says goodbye to dopamine
Daniel R Weinberger Nature Medicine13, 1018–1019
(September 2007); doi:10.1038/nm0907-1018
| Summary | Full Text (HTML / PDF) |
review Translation matters: protein synthesis defects in inherited disease
Gert C. Scheper, Marjo S. van der Knaap & Christopher G. Proud Nature Reviews Genetics8, 711–723
(September 2007); doi:10.1038/nrg2142
| Summary | Full Text (HTML / PDF) |
perspective New insights into BDNF function in depression and anxiety
Keri Martinowich, Husseini Manji & Bai Lu Nature Neuroscience10, 1089–1093
(September 2007); doi:10.1038/nn1971
| Summary | Full Text (HTML / PDF) |
article Prospective identification of myogenic endothelial cells in human skeletal muscle
Bo Zheng, Baohong Cao, Mihaela Crisan, Bin Sun, Guangheng Li, Alison Logar, Solomon Yap, Jonathan B Pollett, Lauren Drowley, Theresa Cassino, Burhan Gharaibeh, Bridget M Deasy, Johnny Huard & Bruno Péault Nature Biotechnology25, 1025–1034
(September 2007); doi:10.1038/nbt1334
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news and views On the iTRAQ of kinase inhibitors
Forest M White Nature Biotechnology25, 994–996
(September 2007); doi:10.1038/nbt0907-994
| Summary | Full Text (HTML / PDF) |
article Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro, Takayuki Nojima, Masatoshi Hagiwara, Ken Ishigami, Hidenori Watanabe, Takeshi Kitahara, Tatsuhiko Yoshida, Hidenori Nakajima, Tokio Tani, Sueharu Horinouchi & Minoru Yoshida Nature Chemical Biology3, 576–583
(September 2007); doi:10.1038/nchembio.2007.18
| Summary | Full Text (HTML / PDF) |
letter Splicing factor SF3b as a target of the antitumor natural product pladienolide
Yoshihiko Kotake, Koji Sagane, Takashi Owa, Yuko Mimori-Kiyosue, Hajime Shimizu, Mai Uesugi, Yasushi Ishihama, Masao Iwata & Yoshiharu Mizui Nature Chemical Biology3, 570–575
(September 2007); doi:10.1038/nchembio.2007.16
| Summary | Full Text (HTML / PDF) |
news and views Targeting the spliceosome
Brian Rymond Nature Chemical Biology3, 533–535
(September 2007); doi:10.1038/nchembio0907-533
| Summary | Full Text (HTML / PDF) |
article Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff, Dirk Eberhard, Yann Abraham, Sonja Bastuck, Markus Boesche, Scott Hobson, Toby Mathieson, Jessica Perrin, Manfred Raida, Christina Rau, Valérie Reader, Gavain Sweetman, Andreas Bauer, Tewis Bouwmeester, Carsten Hopf, Ulrich Kruse, Gitte Neubauer, Nigel Ramsden, Jens Rick, Bernhard Kuster & Gerard Drewes Nature Biotechnology25, 1035–1044
(September 2007); doi:10.1038/nbt1328
| Summary | Full Text (HTML / PDF) |
review Molecular basis for sunitinib efficacy and future clinical development
Sandrine Faivre, George Demetri, William Sargent & Eric Raymond Nature Reviews Drug Discovery6, 734–745
(September 2007); doi:10.1038/nrd2380
| Summary | Full Text (HTML / PDF) |
review Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
Ross L. Levine, Animesh Pardanani, Ayalew Tefferi & D. Gary Gilliland Nature Reviews Cancer7, 673–683
(September 2007); doi:10.1038/nrc2210
| Summary | Full Text (HTML / PDF) |
letter Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype
Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean-Pierre Fryns, Jan Cools, Peter Marynen, Gilles Thomas, Akihiko Yoshimura & Eric Legius Nature Genetics39, 1120–1126
(2007); doi:10.1038/ng2113
| Summary | Full Text (HTML / PDF) |
review The effect of neurodegenerative diseases on the subventricular zone
Maurice A. Curtis, Richard L. M. Faull & Peter S. Eriksson Nature Reviews Neuroscience8, 712–723
(September 2007); doi:10.1038/nrn2216
| Summary | Full Text (HTML / PDF) |
letter A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean-Pierre Yougen Li, D Allan Drummond, Andrew M Sawayama, Christopher D Snow, Jesse D Bloom & Frances H Arnold Nature Biotechnology25, 1051–1056
(2007); doi:10.1038/nbt1333
| Summary | Full Text (HTML / PDF) |
review Targeting virulence: a new paradigm for antimicrobial therapy
Anne E Clatworthy, Emily Pierson & Deborah T Hung Nature Chemical Biology3, 541–548
(September 2007); doi:10.1038/nchembio.2007.24
| Summary | Full Text (HTML / PDF) |
letter Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells
Piotr Kazmierczak, Hirofumi Sakaguchi, Joshua Tokita, Elizabeth M. Wilson-Kubalek, Ronald A. Milligan, Ulrich Müller & Bechara Kachar Nature449, 87–91
(6 September 2007); doi:10.1038/nature06091
| Summary | Full Text (HTML / PDF) |
review Endocrine regulation of ageing
Steven J. Russell & C. Ronald Kahn Nature Reviews Molecular Cell Biology8, 681–691
(September 2007); doi:10.1038/nrm2234
| Summary | Full Text (HTML / PDF) |
review Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Kristin K. Deeb, Donald L. Trump & Candace S. Johnson Nature Reviews Cancer7, 684–700
(September 2007); doi:10.1038/nrc2196
| Summary | Full Text (HTML / PDF) |
perspective Building better magic bullets — improving unconjugated monoclonal antibody therapy for cancer
Louis M. Weiner Nature Reviews Cancer7, 701–706
(September 2007); doi:10.1038/nrc2209
| Summary | Full Text (HTML / PDF) |
letter RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Vivek Shukla, Xavier Coumoul, Rui-Hong Wang, Hyun-Seok Kim & Chu-Xia Deng Nature Genetics39, 1145–1150
(September 2007); doi:10.1038/ng2096
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news and views Cancer drugs to treat birth defects
Andrew O M Wilkie Nature Genetics39, 1057–1059
(September 2007); doi:10.1038/ng0907-1057
| Full Text (HTML / PDF) |
review Translation matters: protein synthesis defects in inherited disease
Gert C. Scheper, Marjo S. van der Knaap & Christopher G. Proud Nature Reviews Genetics8, 711–723
(September 2007); doi:10.1038/nrg2142
| Summary | Full Text (HTML / PDF) |
review Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Jürgen Wess, Richard M. Eglen & Dinesh Gautam Nature Reviews Drug Discovery6, 721–733
(September 2007); doi:10.1038/nrd2379
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August
letter Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Yoshiyuki Minegishi, Masako Saito, Shigeru Tsuchiya, Ikuya Tsuge, Hidetoshi Takada, Toshiro Hara, Nobuaki Kawamura, Tadashi Ariga, Srdjan Pasic, Oliver Stojkovic, Ayse Metin & Hajime Karasuyama Nature448, 1058–1062
(30 August 2007); doi:10.1038/nature06096
| Summary | Full Text (HTML / PDF) |
article E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
Kurt Bachmaier, Sophie Toya, Xiaopei Gao, Thomas Triantafillou, Sean Garrean, Gye Young Park, Randall S Frey, Stephen Vogel, Richard Minshall, John W Christman, Chinnaswamy Tiruppathi & Asrar B Malik Nature Medicine13, 920–926
(August 2007); doi:10.1038/nm1607
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review Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
Teru Hideshima, Constantine Mitsiades, Giovanni Tonon, Paul G. Richardson & Kenneth C. Anderson Nature Reviews Cancer7, 585–598
(August 2007); doi:10.1038/nrc2189
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letter Germline gain-of-function mutations in RAF1 cause Noonan syndrome
M Abdur Razzaque, Tsutomu Nishizawa, Yuta Komoike, Hisato Yagi, Michiko Furutani, Ryunosuke Amo, Mitsuhiro Kamisago, Kazuo Momma, Hiroshi Katayama, Masao Nakagawa, Yuko Fujiwara, Masaki Matsushima, Katsumi Mizuno, Mika Tokuyama, Hamao Hirota, Jun Muneuchi, Toru Higashinakagawa & Rumiko Matsuoka Nature Genetics39, 1013–1017
(August 2007); doi:10.1038/ng2078
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article Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Xiao-Qing Qiu, He Wang, Bei Cai, Lan-Lan Wang & Shi-Tao Yue Nature Biotechnology25, 921–929
(August 2007); doi:10.1038/nbt1320
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news and views Antibodies cut down to size
Robert Charles Ladner Nature Biotechnology25, 875–877
(August 2007); doi:10.1038/nbt0807-875
| Summary | Full Text (HTML / PDF) |
review Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface
Timothy A. McKinsey & David A. Kass Nature Reviews Drug Discovery6, 617–635
(August 2007); doi:10.1038/nrd2193
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article Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1
Yufeng Shi, Yan Feng, Jiuhong Kang, Chang Liu, Zhenxin Li, Dangsheng Li, Wei Cao, Ju Qiu, Zhengliang Guo, Enguang Bi, Lei Zang, Chuanzhen Lu, Jingwu Z Zhang & Gang Pei Nature Immunology8, 817–824
(August 2007); doi:10.1038/ni1489
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news and views Arresting autoimmunity by blocking β-arrestin 1
Terra J Frederick & Stephen D Miller Nature Immunology8, 791–792
(August 2007); doi:10.1038/ni0807-791
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article IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Elena Bulanova, Martin Metz, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Vadim Budagian, Julien Giron-Michel, Ernst Brandt, Ralf Paus & Silvia Bulfone-Paus Nature Medicine13, 927–934
(August 2007); doi:10.1038/nm1615
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news and views The curiosity of IL-15
Peter A Ward Nature Medicine13, 903–904
(August 2007); doi:10.1038/nm0807-903
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article Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
Bernhard Kühn, Federica del Monte, Roger J Hajjar, Yuh-Shin Chang, Djamel Lebeche, Shima Arab & Mark T Keating Nature Medicine13, 962–969
(August 2007); doi:10.1038/nm1619
| Summary | Full Text (HTML / PDF) |
perspective Active-site directed probes to report enzymatic action in the ubiquitin proteasome system
Huib Ovaa Nature Reviews Cancer7, 613–620
(August 2007); doi:10.1038/nrc2128
| Summary | Full Text (HTML / PDF) |
letter Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Bhaswati Pandit, Anna Sarkozy, Len A Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A Pogna, Wendy Schackwitz, Anna Ustaszewska, Andrew Landstrom, J Martijn Bos, Steve R Ommen, Giorgia Esposito, Francesca Lepri, Christian Faul, Peter Mundel, Juan P López Siguero, Romano Tenconi, Angelo Selicorni, Cesare Rossi, Laura Mazzanti, Isabella Torrente, Bruno Marino, Maria C Digilio, Giuseppe Zampino, Michael J Ackerman, Bruno Dallapiccola, Marco Tartaglia & Bruce D Gelb Nature Genetics39, 1007–1012
(August 2007); doi:10.1038/ng2073
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article Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
Nicole-Claudia Meisner, Martin Hintersteiner, Kurt Mueller, Roman Bauer, Jan-Marcus Seifert, Hans-Ulrich Naegeli, Johannes Ottl, Lukas Oberer, Christian Guenat, Serge Moss, Nathalie Harrer, Maximilian Woisetschlaeger, Christof Buehler, Volker Uhl & Manfred Auer Nature Chemical Biology3, 508–515
(August 2007); doi:10.1038/nchembio.2007.14
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commentary Scaffold composition and biological relevance of screening libraries
Anang A Shelat & R Kiplin Guy Nature Chemical Biology3, 442–446
(August 2007); doi:10.1038/nchembio0807-442
| Summary | Full Text (HTML / PDF) |
letter Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Kenshi Yamasaki, Anna Di Nardo, Antonella Bardan, Masamoto Murakami, Takaaki Ohtake, Alvin Coda, Robert A Dorschner, Chrystelle Bonnart, Pascal Descargues, Alain Hovnanian, Vera B Morhenn & Richard L Gallo Nature Medicine13, 975–980
(August 2007); doi:10.1038/nm1616
| Summary | Full Text (HTML / PDF) |
news and views Rosacea: skin innate immunity gone awry?
Charles L Bevins & Fu-Tong Liu Nature Medicine13, 904–906
(August 2007); doi:10.1038/nm0807-904
| Summary | Full Text (HTML / PDF) |
article Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
Marco Idzko, Hamida Hammad, Menno van Nimwegen, Mirjam Kool, Monique A M Willart, Femke Muskens, Henk C Hoogsteden, Werner Luttmann, Davide Ferrari, Francesco Di Virgilio, J Christian Virchow, Jr & Bart N Lambrecht Nature Medicine13, 913–919
(August 2007); doi:10.1038/nm1617
| Summary | Full Text (HTML / PDF) |
review The resurgence of platinum-based cancer chemotherapy
Lloyd Kelland Nature Reviews Cancer7, 573–584
(August 2007); doi:10.1038/nrc2167
| Summary | Full Text (HTML / PDF) |
letter Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
Fudi Wang, Prasad N Paradkar, Angel O Custodio, Diane McVey Ward, Mark D Fleming, Dean Campagna, Kristina A Roberts, Victor Boyartchuk, William F Dietrich, Jerry Kaplan & Nancy C Andrews Nature Genetics39, 1025–1032
(August 2007); doi:10.1038/ng2059
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perspective Embryonic stem cells as a source of models for drug discovery
Colin W. Pouton & John M. Haynes Nature Reviews Drug Discovery6, 605–616
(August 2007); doi:10.1038/nrd2194
| Summary | Full Text (HTML / PDF) |
article Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
Anna Rodina, Maria Vilenchik, Kamalika Moulick, Julia Aguirre, Joungnam Kim, Anne Chiang, Julie Litz, Cristina C Clement, Yanlong Kang, Yuhong She, Nian Wu, Sara Felts, Peter Wipf, Joan Massague, Xuejun Jiang, Jeffrey L Brodsky, Geoffrey W Krystal & Gabriela Chiosis Nature Chemical Biology3, 498–507
(August 2007); doi:10.1038/nchembio.2007.10
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letter Global changes to the ubiquitin system in Huntington's disease
Eric J. Bennett, Thomas A. Shaler, Ben Woodman, Kwon-Yul Ryu, Tatiana S. Zaitseva, Christopher H. Becker, Gillian P. Bates, Howard Schulman & Ron R. Kopito Nature448, 704–708
(9 August 2007); doi:10.1038/nature06022
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review Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
Maria-Grazia Roncarolo & Manuela Battaglia Nature Reviews Immunology7, 585–598
(August 2007); doi:10.1038/nri2138
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perspective Treating prostate cancer: a rationale for targeting local oestrogens
Stuart J. Ellem & Gail P. Risbridger Nature Reviews Cancer7, 621–627
(August 2007); doi:10.1038/nrc2174
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letter Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
Massimo Attanasio, N Henriette Uhlenhaut, Vitor H Sousa, John F O'Toole, Edgar Otto, Katrin Anlag, Claudia Klugmann, Anna-Corina Treier, Juliana Helou, John A Sayer, Dominik Seelow, Gudrun Nürnberg, Christian Becker, Albert E Chudley, Peter Nürnberg, Friedhelm Hildebrandt & Mathias Treier Nature Genetics39, 1018–1024
(August 2007); doi:10.1038/ng2072
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article Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Charles W Pemble IV, Lynnette C Johnson, Steven J Kridel & W Todd Lowther Nature Structural & Molecular Biology14, 704–709
(August 2007); doi:10.1038/nsmb1265
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review CD3-specific antibodies: a portal to the treatment of autoimmunity
Lucienne Chatenoud & Jeffrey A. Bluestone Nature Reviews Immunology7, 622–632
(August 2007); doi:10.1038/nri2134
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brief communication Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Cristina Sobacchi, Annalisa Frattini, Matteo M Guerrini, Mario Abinun, Alessandra Pangrazio, Lucia Susani, Robbert Bredius, Grazia Mancini, Andrew Cant, Nick Bishop, Peter Grabowski, Andrea Del Fattore, Chiara Messina, Gabriella Errigo, Fraser P Coxon, Debbie I Scott, Anna Teti, Michael J Rogers, Paolo Vezzoni, Anna Villa & Miep H Helfrich Nature Genetics39, 960–962
(August 2007); doi:10.1038/ng2076
| Summary | Full Text (HTML / PDF) |
brief communication Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai–Barrow and facio–oculo–acoustico–renal syndromes
Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi, Maria Loscertales, Caroline Robson, Tianming Liu, David T MacLaughlin, Kristin M Noonan, Meaghan K Russell, Christopher A Walsh, Patricia K Donahoe & Barbara R Pober Nature Genetics39, 957–959
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review Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Csaba Szabó, Harry Ischiropoulos & Rafael Radi Nature Reviews Drug Discovery6, 662–680
(August 2007); doi:10.1038/nrd2222
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commentary Reporting data from high-throughput screening of small-molecule libraries
James Inglese, Caroline E Shamu & R Kiplin Guy Nature Chemical Biology3, 438–441
(August 2007); doi:10.1038/nchembio0807-438
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July
letter Protective and therapeutic role for αB-crystallin in autoimmune demyelination
Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman Nature448, 474–479
(26 July 2007); doi:10.1038/nature05935
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news and views Inflammatory disease: Assault on the guardian
Richard M. Ransohoff Nature448, 421–422
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review Unravelling the pathogenesis of inflammatory bowel disease
R. J. Xavier & D. K. Podolsky Nature448, 427–434
(26 July 2007); doi:10.1038/nature06005
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perspective Targeting the protein kinase C family: are we there yet?
Helen J. Mackay & Christopher J. Twelves Nature Reviews Cancer7, 554–562
(July 2007); doi:10.1038/nrc2168
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brief communication A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
David A van Heel, Lude Franke, Karen A Hunt, Rhian Gwilliam, Alexandra Zhernakova, Mike Inouye, Martin C Wapenaar, Martin C N M Barnardo, Graeme Bethel, Geoffrey K T Holmes, Con Feighery, Derek Jewell, Dermot Kelleher, Parveen Kumar, Simon Travis, Julian RF Walters, David S Sanders, Peter Howdle, Jill Swift, Raymond J Playford, William M McLaren, M Luisa Mearin, Chris J Mulder, Ross McManus, Ralph McGinnis, Lon R Cardon, Panos Deloukas & Cisca Wijmenga Nature Genetics39, 827–829
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article Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal, Pal Pacher, Irmgard Tegeder, Fumimasa Amaya, Cristina E Constantin, Gary J Brenner, Tiziana Rubino, Christoph W Michalski, Giovanni Marsicano, Krisztina Monory, Ken Mackie, Claudiu Marian, Sandor Batkai, Daniela Parolaro, Michael J Fischer, Peter Reeh, George Kunos, Michaela Kress, Beat Lutz, Clifford J Woolf & Rohini Kuner Nature Neuroscience10, 870–879
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review The contribution of immunology to the rational design of novel antibacterial vaccines
Stefan H.E. Kaufmann Nature Reviews Microbiology5, 491–504
(July 2007); doi:10.1038/nrmicro1688
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review The perfect mix: recent progress in adjuvant research
Bruno Guy Nature Reviews Microbiology5, 505–517
(July 2007); doi:10.1038/nrmicro1681
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review How Ebola and Marburg viruses battle the immune system
Mansour Mohamadzadeh, Lieping Chen & Alan L. Schmaljohn Nature Reviews Immunology7, 556–694
(July 2007); doi:10.1038/nri2098
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article Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
Andrei Goga, Dun Yang, Aaron D Tward, David O Morgan & J Michael Bishop Nature Medicine13, 820–827
(July 2007); doi:10.1038/nm1606
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perspective Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?
Christos Sotiriou & Martine J. Piccart Nature Reviews Cancer7, 545–553
(July 2007); doi:10.1038/nrc2173
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brief communication Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia
Karl-Heinz Grzeschik, Dorothea Bornholdt, Frank Oeffner, Arne König, María del Carmen Boente, Herbert Enders, Barbara Fritz, Michael Hertl, Ute Grasshoff, Katja Höfling, Vinzenz Oji, Mauro Paradisi, Christian Schuchardt, Zsuzsanna Szalai, Gianluca Tadini, Heiko Traupe & Rudolf Happle Nature Genetics39, 833–835
(July 2007); doi:10.1038/ng2052
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brief communication Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia
Xiaoling Wang, V Reid Sutton, J Omar Peraza-Llanes, Zhiyin Yu, Rebecca Rosetta, Ying-Chuck Kou, Tanya N Eble, Ankita Patel, Christina Thaller, Ping Fang & Ignatia B Van den Veyver Nature Genetics39, 836–838
(July 2007); doi:10.1038/ng2057
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news and views Wnt signaling in focal dermal hypoplasia
Amy S Paller Nature Genetics39, 820–821
(July 2007); doi:10.1038/ng0707-820
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review Utilizing RNA interference to enhance cancer drug discovery
Elizabeth Iorns, Christopher J. Lord, Nicholas Turner & Alan Ashworth Nature Reviews Drug Discovery6, 556–568
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review Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development
Gary J. Kelloff & Caroline C. Sigman Nature Reviews Cancer7, 508–518
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review Intracellular amyloid-β in Alzheimer's disease
Frank M. LaFerla, Kim N. Green & Salvatore Oddo Nature Reviews Neuroscience8, 499–509
(July 2007); doi:10.1038/nrn2168
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letter Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
Päivi Lindholm, Merja H. Voutilainen, Juha Laurén, Johan Peränen, Veli-Matti Leppänen, Jaan-Olle Andressoo, Maria Lindahl, Sanna Janhunen, Nisse Kalkkinen, Tõnis Timmusk, Raimo K. Tuominen & Mart Saarma Nature448, 73–77
(5 July 2007); doi:10.1038/nature05957
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letter Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
John A Todd et al. Nature Genetics39, 857–864
(July 2007); doi:10.1038/ng2068
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brief communication Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Miles Parkes et al. Nature Genetics39, 830–832
(July 2007); doi:10.1038/ng2061
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news and views Guilt beyond a reasonable doubt
David Altshuler & Mark Daly Nature Genetics39, 813–815
(July 2007); doi:10.1038/ng0707-813
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review Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
Panagiotis A. Konstantinopoulos, Michalis V. Karamouzis & Athanasios G. Papavassiliou Nature Reviews Drug Discovery6, 541–555
(July 2007); doi:10.1038/nrd2221
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June
article 'Rejuvenation' protects neurons in mouse models of Parkinson's disease
C. Savio Chan, Jaime N. Guzman, Ema Ilijic, Jeff N. Mercer, Caroline Rick, Tatiana Tkatch, Gloria E. Meredith & D. James Surmeier Nature447, 1081–1086
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review Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst & Boudewijn M.T. Burgering Nature Reviews Molecular Cell Biology8, 440–450
(June 2007); doi:10.1038/nrm2190
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article Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
Ashleigh Hodges, Katherine Sharrocks, Mariola Edelmann, Dilair Baban, Arnaud Moris, Olivier Schwartz, Hal Drakesmith, Kay Davies, Benedikt Kessler, Andrew McMichael & Alison Simmons Nature Immunology8, 569–577
(June 2007); doi:10.1038/ni1470
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news and views DC-SIGN 'AIDS' HIV immune evasion and infection
Anthony L Cunningham, Andrew N Harman & Heather Donaghy Nature Immunology8, 556–558
(June 2007); doi:10.1038/ni0607-556
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review Cytokines in the pathogenesis of rheumatoid arthritis
Iain B. McInnes & Georg Schett Nature Reviews Immunology7, 429–442
(June 2007); doi:10.1038/nri2094
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letter Mast cells promote atherosclerosis by releasing proinflammatory cytokines
Jiusong Sun, Galina K Sukhova, Paul J Wolters, Min Yang, Shiro Kitamoto, Peter Libby, Lindsey A MacFarlane, Jon Mallen-St Clair & Guo-Ping Shi Nature Medicine13, 719–724
(June 2007); doi:10.1038/nm1601
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news and views HER3 and mutant EGFR meet MET
Carlos L Arteaga Nature Medicine13, 675–677
(June 2007); doi:10.1038/nm0607-675
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review Microenvironmental regulation of biomacromolecular therapies
Hyun Joon Kong & David J. Mooney Nature Reviews Drug Discovery6, 455–463
(June 2007); doi:10.1038/nrd2309
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article Exploitation of structural and regulatory diversity in glutamate racemases
Tomas Lundqvist, Stewart L. Fisher, Gunther Kern, Rutger H. A. Folmer, Yafeng Xue, D. Trevor Newton, Thomas A. Keating, Richard A. Alm & Boudewijn L. M. de Jonge Nature447, 817–822
(14 June 2007); doi:10.1038/nature05689
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letter Caspase-14 protects against epidermal UVB photodamage and water loss
Geertrui Denecker, Esther Hoste, Barbara Gilbert, Tino Hochepied, Petra Ovaere, Saskia Lippens, Caroline Van den Broecke, Petra Van Damme, Katharina D'Herde, Jean-Pierre Hachem, Gaetan Borgonie, Richard B. Presland, Luc Schoonjans, Claude Libert, Joël Vandekerckhove, Kris Gevaert, Peter Vandenabeele & Wim Declercq Nature Cell Biology9, 666–674
(June 2007); doi:10.1038/ncb1597
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news and views Caspase-14 and epidermis maturation
Pierluigi Nicotera & Gerry Melino Nature Cell Biology9, 621–622
(June 2007); doi:10.1038/ncb0607-621
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progress Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation
Leonardo Salmena & Pier Paolo Pandolfi Nature Reviews Cancer7, 409–413
(June 2007); doi:10.1038/nrc2145
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progress Interfering with disease: a progress report on siRNA-based therapeutics
Antonin de Fougerolles, Hans-Peter Vornlocher, John Maraganore & Judy Lieberman Nature Reviews Drug Discovery6, 443–453
(June 2007); doi:10.1038/nrd2310
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article Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium Nature447, 661–678
(7 June 2007); doi:10.1038/nature05911
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news and views Genomics: Guilt by association
Anne M. Bowcock Nature447, 645–646
(7 June 2007); doi:10.1038/447645a
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review Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
Jialiang Hu, Philippe E. Van den Steen, Qing-Xiang A. Sang & Ghislain Opdenakker Nature Reviews Drug Discovery6, 480–498
(June 2007); doi:10.1038/nrd2308
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May
news and views Epithelial NF-κB maintains host gut microflora homeostasis
Yinon Ben-Neriah & Marc Schmidt-Supprian Nature Immunology8, 479–481
(May 2007); doi:10.1038/ni0507-479
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article Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets
Georgina Xanthou, Themis Alissafi, Maria Semitekolou, Davina C M Simoes, Erasmia Economidou, Mina Gaga, Bart N Lambrecht, Clare M Lloyd & Vily Panoutsakopoulou Nature Medicine13, 570–578
(May 2007); doi:10.1038/nm1580
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news and views The bridge between dendritic cells and asthma
Mari L Shinohara & Harvey Cantor Nature Medicine13, 536–538
(May 2007); doi:10.1038/nm0507-536
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article Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
Ursula Grohmann, Claudia Volpi, Francesca Fallarino, Silvia Bozza, Roberta Bianchi, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Emira Ayroldi, Giuseppe Nocentini, Louis Boon, Francesco Bistoni, Maria C Fioretti, Luigina Romani, Carlo Riccardi & Paolo Puccetti Nature Medicine13, 579–586
(May 2007); doi:10.1038/nm1563
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progress The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
Gavin Thurston, Irene Noguera-Troise & George D. Yancopoulos Nature Reviews Cancer7, 327–331
(May 2007); doi:10.1038/nrc2130
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review More than one reason to rethink the use of peptides in vaccine design
Anthony W. Purcell, James McCluskey & Jamie Rossjohn Nature Reviews Drug Discovery6, 404–414
(May 2007); doi:10.1038/nrd2224
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news and views Autism: highly heritable but not inherited
Arthur L Beaudet Nature Methods13, 534–536
(May 2007); doi:10.1038/nm0507-534
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review TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Roberto Baccala, Kasper Hoebe, Dwight H Kono, Bruce Beutler & Argyrios N Theofilopoulos Nature Methods13, 543–551
(May 2007); doi:10.1038/nm1590
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review Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman Nature Methods13, 552–559
(May 2007); doi:10.1038/nm1589
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review Second generation inhibitors of BCR–ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
Ellen Weisberg, Paul W. Manley, Sandra W. Cowan-Jacob, Andreas Hochhaus & James D. Griffin Nature Reviews Cancer7, 345–356
(May 2007); doi:10.1038/nrc2126
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perspective Insights from transgenic mouse models of ERBB2-induced breast cancer
Josie Ursini-Siegel, Babette Schade, Robert D. Cardiff & William J. Muller Nature Reviews Cancer7, 389–397
(May 2007); doi:10.1038/nrc2127
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letter Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Klaus Dieterich, Ricardo Soto Rifo, Anne Karen Faure, Sylviane Hennebicq, Baha Ben Amar, Mohamed Zahi, Julia Perrin, Delphine Martinez, Bernard Sèle, Pierre-Simon Jouk, Théophile Ohlmann, Sophie Rousseaux, Joel Lunardi & Pierre F Ray Nature Genetics39, 661–665
(May 2007); doi:10.1038/ng2027
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review The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
Arpad Szallasi, Daniel N. Cortright, Charles A. Blum & Samer R. Eid Nature Reviews Drug Discovery6, 357–372
(May 2007); doi:10.1038/nrd2280
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perspective Development trends for monoclonal antibody cancer therapeutics
Janice M. Reichert & Viia E. Valge-Archer Nature Reviews Drug Discovery6, 349–356
(May 2007); doi:10.1038/nrd2241
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news and views Behavioural neuroscience: Down memory lane
J. David Sweatt Nature447, 151–152
(10 May 2007); doi:10.1038/nature05716
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letter pVHL and GSK3β are components of a primary cilium-maintenance signalling network
Claudio R. Thoma, Ian J. Frew, Christian R. Hoerner, Matteo Montani, Holger Moch & Wilhelm Krek Nature Cell Biology9, 588–595
(May 2007); doi:10.1038/ncb1579
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article MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen, Regina Krohn, Hongqi Lue, Julia L Gregory, Alma Zernecke, Rory R Koenen, Manfred Dewor, Ivan Georgiev, Andreas Schober, Lin Leng, Teake Kooistra, Günter Fingerle-Rowson, Pietro Ghezzi, Robert Kleemann, Shaun R McColl, Richard Bucala, Michael J Hickey & Christian Weber Nature Medicine13, 587–596
(May 2007); doi:10.1038/nm1567
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research A risk-based bioanalytical strategy for the assessment of antibody immune responses against biological drugs
Gopi Shankar, Charles Pendley & Kathryn E Stein Nature Biotechnology25, 555–561
(May 2007); doi:10.1038/nbt1303
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review Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
Kate L. Jeffrey, Montserrat Camps, Christian Rommel & Charles R. Mackay Nature Reviews Drug Discovery6, 391–403
(May 2007); doi:10.1038/nrd2289
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review Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
Thomas Force, Daniela S. Krause & Richard A. Van Etten Nature Reviews Cancer7, 332–344
(May 2007); doi:10.1038/nrc2106
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April
letter Opioids block long-term potentiation of inhibitory synapses
Fereshteh S. Nugent, Esther C. Penick & Julie A. Kauer Nature446, 1086–1090
(26 April 2007); doi:10.1038/nature05726
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news and views Providing AID to p53 mutagenesis
Shigeo Takaishi & Timothy C Wang Nature Medicine13, 404–406
(April 2007); doi:10.1038/nm0407-404
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article Angiogenic inhibition reduces germinal matrix hemorrhage
Praveen Ballabh, Hongmin Xu, Furong Hu, Alex Braun, Kira Smith, Aracelie Rivera, Nanhong Lou, Zoltan Ungvari, Steven A Goldman, Anna Csiszar & Maiken Nedergaard Nature Medicine13, 477–485
(April 2007); doi:10.1038/nm1558
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commentary Recommendations of the 2006 Human Variome Project meeting
Richard G.H. Cotton Nature Genetics39, 433–436
(April 2007); doi:10.1038/ng2024
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perspective Channel, neuronal and clinical function in sodium channelopathies: from genotype to phenotype
Stephen G Waxman Nature Neuroscience10, 405–409
(April 2007); doi:10.1038/nn1857
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review Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
Roy Pettipher, Trevor T. Hansel & Richard Armer Nature Reviews Drug Discovery6, 313–325
(April 2007); doi:10.1038/nrd2266
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perspective Angiogenesis: an organizing principle for drug discovery?
Judah Folkman Nature Reviews Drug Discovery6, 273–286
(April 2007); doi:10.1038/nrd2115
| Summary | Full Text (HTML / PDF) |
article Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Susanne Ludwiczek, Igor Theurl, Martina U Muckenthaler, Martin Jakab, Sabine M Mair, Milan Theurl, Judit Kiss, Markus Paulmichl, Matthias W Hentze, Markus Ritter & Guenter Weiss Nature Medicine13, 448–454
(April 2007); doi:10.1038/nm1542
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article Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen R Clark, Adrienne C Ma, Samantha A Tavener, Braedon McDonald, Zahra Goodarzi, Margaret M Kelly, Kamala D Patel, Subhadeep Chakrabarti, Erin McAvoy, Gary D Sinclair, Elizabeth M Keys, Emma Allen-Vercoe, Rebekah DeVinney, Christopher J Doig, Francis H Y Green & Paul Kubes Nature Medicine13, 463–469
(April 2007); doi:10.1038/nm1565
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news and views Netting bacteria in sepsis
Constantin Urban & Arturo Zychlinsky Nature Medicine13, 403–404
(April 2007); doi:10.1038/nm0407-403
| Summary | Full Text (HTML / PDF) |
letter The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen & Zhiguo Wang Nature Medicine13, 486–491
(April 2007); doi:10.1038/nm1569
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technical report MRI detection of transcriptional regulation of gene expression in transgenic mice
Batya Cohen, Keren Ziv, Vicki Plaks, Tomer Israely, Vyacheslav Kalchenko, Alon Harmelin, Laura E Benjamin & Michal Neeman Nature Medicine13, 498–503
(April 2007); doi:10.1038/nm1497
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technical report Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes
Marina V Backer, Zoya Levashova, Vimalkumar Patel, Brian T Jehning, Kevin Claffey, Francis G Blankenberg & Joseph M Backer Nature Medicine13, 504–509
(April 2007); doi:10.1038/nm1522
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letter A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
Chiea C Khor, Stephen J Chapman, Fredrik O Vannberg, Aisling Dunne, Caroline Murphy, Edmund Y Ling, Angela J Frodsham, Andrew J Walley, Otto Kyrieleis, Amir Khan, Christophe Aucan, Shelley Segal, Catrin E Moore, Kyle Knox, Sarah J Campbell, Christian Lienhardt, Anthony Scott, Peter Aaby, Oumou Y Sow, Robert T Grignani, Jackson Sillah, Giorgio Sirugo, Nobert Peshu, Thomas N Williams, Kathryn Maitland, Robert J O Davies, Dominic P Kwiatkowski, Nicholas P Day, Djamel Yala, Derrick W Crook, Kevin Marsh, James A Berkley, Luke A J O'Neill & Adrian V S Hill Nature Genetics39, 523–528
(April 2007); doi:10.1038/ng1976
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review Potential therapeutic applications of autophagy
David C. Rubinsztein, Jason E. Gestwicki, Leon O. Murphy & Daniel J. Klionsky Nature Reviews Drug Discovery6, 304–312
(April 2007); doi:10.1038/nrd2272
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article Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
Jimmy A Blair, Daniel Rauh, Charles Kung, Cai-Hong Yun, Qi-Wen Fan, Haridas Rode, Chao Zhang, Michael J Eck, William A Weiss and Kevan M Shokat Nature Chemical Biology3, 229–238
(April 2007); doi:10.1038/nchembio866
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letter Synthetic lethal screen identification of chemosensitizer loci in cancer cells
Angelique W. Whitehurst, Brian O. Bodemann, Jessica Cardenas, Deborah Ferguson, Luc Girard, Michael Peyton, John D. Minna, Carolyn Michnoff, Weihua Hao, Michael G. Roth, Xian-Jin Xie & Michael A. White Nature446, 815–819
(11 April 2007); doi:10.1038/nature05697
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review p53 in health and disease
Karen H. Vousden & David P. Lane Nature Reviews Molecular Cell Biology8, 275–283
(April 2007); doi:10.1038/nrm2147
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perspective Shaping the future of biomarker research in breast cancer to ensure clinical relevance
M. Carolina Hinestrosa, Kay Dickersin, Pamela Klein, Musa Mayer, Karin Noss, Dennis Slamon, George Sledge & Frances M. Visco Nature Reviews Cancer7, 309–315
(April 2007); doi:10.1038/nrc2113
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perspective Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers
Mark R. Trusheim, Ernst R. Berndt & Frank L. Douglas Nature Reviews Drug Discovery6, 287–293
(April 2007); doi:10.1038/nrd2251
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March
letter Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F. Neurath & Manolis Pasparakis Nature446, 557–561
(29 March 2007); doi:10.1038/nature05698
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article Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity
Chinmay M Trivedi, Yang Luo, Zhan Yin, Maozhen Zhang, Wenting Zhu, Tao Wang, Thomas Floss, Martin Goettlicher, Patricia Ruiz Noppinger, Wolfgang Wurst, Victor A Ferrari, Charles S Abrams, Peter J Gruber & Jonathan A Epstein Nature Medicine13, 324–331
(March 2007); doi:10.1038/nm1552
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article IFN-γ mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy
Vanessa Berner, Haiyan Liu, Qing Zhou, Kory L Alderson, Kai Sun, Jonathan M Weiss, Timothy C Back, Dan L Longo, Bruce R Blazar, Robert H Wiltrout, Lisbeth A Welniak, Doug Redelman & William J Murphy Nature Medicine13, 354–360
(March 2007); doi:10.1038/nm1554
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news and views Vaccine leads to memory loss
John B A G Haanen & Ton N M Schumacher Nature Medicine13, 248–250
(March 2007); doi:10.1038/nm0307-248
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review Epidermal growth factor receptor mutations in lung cancer
Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman & Daniel A. Haber Nature Reviews Cancer7, 169–181
(March 2007); doi:10.1038/nrc2088
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article Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
Anastasios Lymperopoulos, Giuseppe Rengo, Hajime Funakoshi, Andrea D Eckhart & Walter J Koch Nature Medicine13, 315–323
(March 2007); doi:10.1038/nm1553
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news and views Long-distance affair with adrenal GRK2 hangs up heart failure
Stephen B Liggett Nature Medicine13, 246–248
(March 2007); doi:10.1038/nm0307-246
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article ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor
Zhiming Yang, Yu-Jia Chang, I-Chen Yu, Shuyuan Yeh, Cheng-Chia Wu, Hiroshi Miyamoto, Diane E Merry, Gen Sobue, Lu-Min Chen, Shu-Shi Chang & Chawnshang Chang Nature Medicine13, 348–353
(March 2007); doi:10.1038/nm1547
| Summary | Full Text (HTML / PDF) |
review High-throughput electronic biology: mining information for drug discovery
William Loging, Lee Harland and Bryn Williams-Jones Nature Reviews Drug Discovery6, 220–230
(March 2007); doi:10.1038/nrd2265
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letter A clickable inhibitor reveals context-dependent autoactivation of p90 RSK
Michael S Cohen, Haralambos Hadjivassiliou and Jack Taunton Nature Chemical Biology3, 156–160
(March 2007); doi:10.1038/nchembio859
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news and views A RSK kinase inhibitor reporting its selectivity in vivo
Morten Frödin Nature Chemical Biology3, 138–139
(March 2007); doi:10.1038/nchembio0307-138
| Summary | Full Text (HTML / PDF) |
news and views Cracking the cytokine code in psoriasis
Brian J Nickoloff Nature Medicine13, 242–244
(March 2007); doi:10.1038/nm0307-242
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news and views Skin safety
Charlotte Schubert Nature Medicine13, 244
(March 2007); doi:10.1038/nm0307-244
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letter Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice
Karen J. Liu, Joseph R. Arron, Kryn Stankunas, Gerald R. Crabtree and Michael T. Longaker Nature446, 79–82
(1 March 2007); doi:10.1038/nature05557
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letter Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses
Sheli R. Radoshitzky, Jonathan Abraham, Christina F. Spiropoulou, Jens H. Kuhn, Dan Nguyen, Wenhui Li, Jane Nagel, Paul J. Schmidt, Jack H. Nunberg, Nancy C. Andrews, Michael Farzan and Hyeryun Choe Nature446, 92–96
(1 March 2007); doi:10.1038/nature05539
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letter Gating pore current in an inherited ion channelopathy
Stanislav Sokolov, Todd Scheuer and William A. Catterall Nature446, 76–78
(1 March 2007); doi:10.1038/nature05598
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news and views Physiology: Legacy of leaky channels
Richard Horn Nature446, 32–34
(1 March 2007); doi:10.1038/446032a
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review PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?
Christian Rommel, Montserrat Camps and Hong Ji Nature Reviews Immunology7, 191–201
(March 2007); doi:10.1038/nri2036
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review Strategies for silencing human disease using RNA interference
Daniel H. Kim and John J. Rossi Nature Reviews Genetics8, 173–184
(March 2007); doi:10.1038/nrg2006
| Summary | Full Text (HTML / PDF) |
February
article A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, David Meyre, Constantin Polychronakos and Philippe Froguel Nature445, 881–885
(22 February 2007); doi:10.1038/nature05616
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brief communication arising Bone Metastasis: Can osteoclasts be excluded?
T. John Martin and Gregory R. Mundy Nature445, E19
(22 February 2007); doi:10.1038/nature05657
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brief communication arising Bone Metastasis: Can osteoclasts be excluded? (Reply)
D. Holstead Jones, Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki, Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger Nature445, E19
(22 February 2007); doi:10.1038/nature05658
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article Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
Philipp A Lang, Marcus Schenck, Jan P Nicolay, Jan Ulrich Becker, Daniela S Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A Klarl, Herbert Rübben, Kurt W Schmid, Klaus Mann, Sibylle Hildenbrand, Harald Hefter, Stephan M Huber, Thomas Wieder, Andreas Erhardt, Dieter Häussinger, Erich Gulbins & Florian Lang Nature Medicine13, 164–170
(February 2007); doi:10.1038/nm1539
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letter A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Jochen Hampe, Andre Franke, Philip Rosenstiel, Andreas Till, Markus Teuber, Klaus Huse, Mario Albrecht, Gabriele Mayr, Francisco M De La Vega, Jason Briggs, Simone Günther, Natalie J Prescott, Clive M Onnie, Robert Häsler, Bence Sipos, Ulrich R Fölsch, Thomas Lengauer, Matthias Platzer, Christopher G Mathew, Michael Krawczak & Stefan Schreiber Nature Genetics39, 207–211
(February 2007); doi:10.1038/ng1954
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letter A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction
Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, Koichi Matsuda, Koji Yonemoto, Toshiaki Nakano, Tomonaga Matsushita, Keiko Yamazaki, Yozo Ohnishi, Susumu Saito, Takanari Kitazono, Setsuro Ibayashi, Katsuo Sueishi, Mitsuo Iida, Yusuke Nakamura & Yutaka Kiyohara Nature Genetics39, 212–217
(February 2007); doi:10.1038/ng1945
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letter Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
Agnar Helgason, Snæbjörn Pálsson, Gudmar Thorleifsson, Struan F A Grant, Valur Emilsson, Steinunn Gunnarsdottir, Adebowale Adeyemo, Yuanxiu Chen, Guanjie Chen, Inga Reynisdottir, Rafn Benediktsson, Anke Hinney, Torben Hansen, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Helmut Schäfer, Mezbah Faruque, Ayo Doumatey, Jie Zhou, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Gunnar Sigurdsson, Johannes Hebebrand, Oluf Pedersen, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Charles Rotimi & Kári Stefánsson Nature Genetics39, 218–225
(February 2007); doi:10.1038/ng1960
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letter Bioinformatic discovery of novel bioactive peptides
Richard J Edwards, Niamh Moran, Marc Devocelle, Aoife Kiernan, Gerardene Meade, William Signac, Martina Foy, Stephen D E Park, Eimear Dunne, Dermot Kenny and Denis C Shields Nature Chemical Biology3, 108–112
(February 2007); doi:10.1038/nchembio854
| Summary | Full Text (HTML / PDF) |
letter Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng, Dimitry M. Danilenko, Patricia Valdez, Ian Kasman, Jeffrey Eastham-Anderson, Jianfeng Wu and Wenjun Ouyang Nature445, 648–651
(15 February 2007); doi:10.1038/nature05505
| First Paragraph | Full Text (HTML / PDF) |
letter Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Mats Hellström, Li-Kun Phng, Jennifer J. Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano, Keejung Yoon, Janet Rossant, M. Luisa Iruela-Arispe, Mattias Kalén, Holger Gerhardt and Christer Betsholtz Nature445, 776–780
(15 February 2007); doi:10.1038/nature05571
| First Paragraph | Full Text (HTML / PDF) |
news and views Vascular Biology: Vessel guidance
Thomas Gridley Nature445, 722–723
(15 February 2007); doi:10.1038/445722a
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brief communication Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
Bing Xia, Josephine C Dorsman, Najim Ameziane, Yne de Vries, Martin A Rooimans, Qing Sheng, Gerard Pals, Abdellatif Errami, Eliane Gluckman, Julian Llera, Weidong Wang, David M Livingston, Hans Joenje & Johan P de Winter Nature Genetics39, 159–161
(February 2007); doi:10.1038/ng1942
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article Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
Jane A Leopold, Aamir Dam, Bradley A Maron, Anne W Scribner, Ronglih Liao, Diane E Handy, Robert C Stanton, Bertram Pitt & Joseph Loscalzo Nature Medicine13, 189–197
(February 2007); doi:10.1038/nm1545
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article Dickkopf-1 is a master regulator of joint remodeling
Danielle Diarra, Marina Stolina, Karin Polzer, Jochen Zwerina, Michael S Ominsky, Denise Dwyer, Adelheid Korb, Josef Smolen, Markus Hoffmann, Clemens Scheinecker, Desiree van der Heide, Robert Landewe, Dave Lacey, William G Richards & Georg Schett Nature Medicine13, 156–163
(February 2007); doi:10.1038/nm1538
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news and views Eating bone or adding it: the Wnt pathway decides
Steven R Goldring & Mary B Goldring Nature Medicine13, 133–134
(February 2007); doi:10.1038/nm0207-133
| Summary | Full Text (HTML / PDF) |
letter Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states
Ronald D Cohn, Christel van Erp, Jennifer P Habashi, Arshia A Soleimani, Erin C Klein, Matthew T Lisi, Matthew Gamradt, Colette M ap Rhys, Tammy M Holm, Bart L Loeys, Francesco Ramirez, Daniel P Judge, Christopher W Ward & Harry C Dietz Nature Medicine13, 204–210
(February 2007); doi:10.1038/nm1536
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news and views ACE inhibitor bulks up muscle
Jeffrey S Chamberlain Nature Medicine13, 125–126
(February 2007); doi:10.1038/nm0207-125
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perspective The tumour microenvironment as a target for chemoprevention
Adriana Albini and Michael B. Sporn Nature Reviews Cancer7,
(February 2007); doi:10.1038/nrc2067
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perspective Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
Paul A Marks & Ronald Breslow Nature Biotechnology25, 84–90
(February 2007); doi:10.1038/nbt1272
| Summary | Full Text (HTML / PDF) |
perspective Why is cancer drug discovery so difficult?
Alexander Kamb, Susan Wee and Christoph Lengauer Nature Reviews Drug Discovery6, 115–120
(February 2007); doi:10.1038/nrd2155
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January
article Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid, Antoine Tesniere, François Ghiringhelli, Gian Maria Fimia, Lionel Apetoh, Jean-Luc Perfettini, Maria Castedo, Grégoire Mignot, Theoharis Panaretakis, Noelia Casares, Didier Métivier, Nathanael Larochette, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini, Laurence Zitvogel & Guido Kroemer Nature Medicine13, 54–61
(January 2007); doi:10.1038/nm1523
| Summary | Full Text (HTML / PDF) |
opinion Chemoprevention of breast cancer with selective oestrogen-receptor modulators
V. Craig Jordan Nature Reviews Cancer7, 46–53
(January 2007); doi:10.1038/nrc2048
| Summary | Full Text (HTML / PDF) |
