Research library: Clinical / Drug discovery
2008:
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July
article
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
Enming J Su et al.
Nature Medicine 14, 731–737
(July 2008); doi:10.1038/nm1787
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news and views
Imatinib buys time for brain after stroke
Peter Rieckmann
Nature Medicine 14, 712–713
(July 2008); doi:10.1038/nm0708-712
| Full Text (HTML / PDF) |
research
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1
Yukihiko Aikawa et al.
Nature Biotechnology 26, 817–823
(July 2008); doi:10.1038/nbt1412
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review
Purinergic signalling and disorders of the central nervous system
Geoffrey Burnstock
Nature Reviews Drug Discovery 7, 575–590
(July 2008); doi:10.1038/nrd2605
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review
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Roberto Cattaneo, Tanner Miest, Elena V. Shashkova & Michael A. Barry
Nature Reviews Microbiology 6, 529–540
(July 2008); doi:10.1038/nrmicro1927
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June
article
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
Edy Y Kim et al.
Nature Medicine 14, 633–640
(June 2008); doi:10.1038/nm1770
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news and views
Lung NKT cell commotion takes your breath away
Sebastian Joyce & Luc Van Kaer
Nature Medicine 14, 609–610
(June 2008); doi:10.1038/nm0608-609
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letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
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review
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
Nature Reviews Neuroscience 9, 437–452
(June 2008); doi:10.1038/nrn2392
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review
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
Masato Furuhashi & Gökhan S. Hotamisligil
Nature Reviews Drug Discovery 7, 489–503
(June 2008); doi:10.1038/nrd2589
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article
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
Alessia Montagnoli et al.
Nature Chemical Biology 4, 357–365
(June 2008); doi:10.1038/nchembio.90
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news and views
Stopping replication, at the beginning
Peter K Jackson
Nature Chemical Biology 4, 331–332
(June 2008); doi:10.1038/nchembio0608-331
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letter
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
Keizo Kanasaki et al.
Nature 453, 1117–1121
(19 June 2008); doi:10.1038/nature06951
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letter
Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
Terrence Town et al.
Nature Medicine 14, 681–687
(June 2008); doi:10.1038/nm1781
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review
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Paolo M. Comoglio, Silvia Giordano & Livio Trusolino
Nature Reviews Drug Discovery 7, 504–516
(June 2008); doi:10.1038/nrd2530
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letter
Substrate-targeting γ-secretase modulators
Thomas L. Kukar et al.
Nature 453, 925–929
(12 June 2008); doi:10.1038/nature07055
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news and views
Biochemistry: Molecular cloaking devices
Thomas Kodadek
Nature 453, 861–862
(12 June 2008); doi:10.1038/453861a
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review
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
Nature Reviews Neuroscience 9, 437–452
(June 2008); doi:10.1038/nrn2392
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May
letter
CLEC5A is critical for dengue-virus-induced lethal disease
Szu-Ting Chen et al.
Nature 453, 672–676
(29 May 2008); doi:10.1038/nature07013
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article
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure
Stephen B Liggett et al.
Nature Medicine 14, 510–517
(May 2008); doi:10.1038/nm1750
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news and views
β-adrenergic signaling in heart failure—adapt or die
Thomas Eschenhagen
Nature Medicine 14, 485–487
(May 2008); doi:10.1038/nm0508-485
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perspective
Wnt signalling and its impact on development and cancer
Alexandra Klaus & Walter Birchmeier
Nature Reviews Cancer 8, 387–398
(May 2008); doi:10.1038/nrc2389
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article
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma
Nandini Krishnamoorthy et al.
Nature Medicine 14, 565–573
(May 2008); doi:10.1038/nm1766
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news and views
Dust mites' dirty dealings with dendritic cells
Dean Sheppard
Nature Medicine 14, 487–488
(May 2008); doi:10.1038/nm0508-487
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review
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Klaus Pantel, Ruud H. Brakenhoff & Burkhard Brandt
Nature Reviews Cancer 8, 329–340
(May 2008); doi:10.1038/nrc2375
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article
Functional roles for C5a receptors in sepsis
Daniel Rittirsch et al.
Nature Medicine 14, 551–557
(May 2008); doi:10.1038/nm1753
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article
Stromal gene expression predicts clinical outcome in breast cancer
Greg Finak et al.
Nature Medicine 14, 518–527
(May 2008); doi:10.1038/nm1764
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review
Getting to the stem of chronic myeloid leukaemia
Michael Savona & Moshe Talpaz
Nature Reviews Cancer 8, 341–350
(May 2008); doi:10.1038/nrc2368
| Summary | Full Text (HTML / PDF) |
article
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
Nature Chemical Biology 5, 295–305
(May 2008); doi:10.1038/nchembio.79
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article
CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells
Sylvain Perruche, Pin Zhang, Yongzhong Liu, Philippe Saas, Jeffrey A Bluestone & WanJun Chen
Nature Medicine 14, 528–535
(May 2008); doi:10.1038/nm1749
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perspective
A new penumbra: transitioning from injury into repair after stroke
Eng H Lo
Nature Medicine 14, 497–500
(May 2008); doi:10.1038/nm1735
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letter
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
Jacques Behmoaras et al.
Nature Genetics 40, 553–559
(May 2008); doi:10.1038/ng.137
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review
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Nicholas P. Franks
Nature Reviews Neuroscience 9, 370–386
(May 2008); doi:10.1038/nrn2372
| Summary | Full Text (HTML / PDF) |
review
The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting
Jeffrey A. Winkles
Nature Reviews Drug Discovery 7, 411–425
(May 2008); doi:10.1038/nrd2488
| Summary | Full Text (HTML / PDF) |
April
review
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerström & Helgi B. Schiöth
Nature Reviews Drug Discovery 7, 339–357
(April 2008); doi:10.1038/nrd2518
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review
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
Jarl E. S. Wikberg & Felikss Mutulis
Nature Reviews Drug Discovery 7, 307–323
(April 2008); doi:10.1038/nrd2331
| Summary | Full Text (HTML / PDF) |
review
Cell-division inhibitors: new insights for future antibiotics
Rowena L. Lock & Elizabeth J. Harry
Nature Reviews Drug Discovery 7, 324–338
(April 2008); doi:10.1038/nrd2510
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article
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
Janghoo Lim et al.
Nature 452, 713–718
(10 April 2008); doi:10.1038/nature06731
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news and views
Neurodegeneration: A question of balance
Leslie Michels Thompson
Nature 452, 707–708
(10 April 2008); doi:10.1038/452707a
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letter
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Michael Groll et al.
Nature 452, 755–758
(10 April 2008); doi:10.1038/nature06782
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letter
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Joshua D. Milner et al.
Nature 452, 773–776
(10 April 2008); doi:10.1038/nature06764
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perspective
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Rakesh K. Jain
Nature Reviews Cancer 8, 309–316
(April 2008); doi:10.1038/nrc2346
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review
High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev & Robert Arias
Nature Reviews Drug Discovery 7, 358–368
(April 2008); doi:10.1038/nrd2552
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review
The cancer biomarker problem
Charles L. Sawyers
Nature 452, 548–552
(3 April 2008); doi:10.1038/nature06913
| Summary | Full Text (HTML / PDF) |
review
Translating insights from the cancer genome into clinical practice
Lynda Chin & Joe W. Gray
Nature 452, 553–552
(3 April 2008); doi:10.1038/nature06914
| Summary | Full Text (HTML / PDF) |
review
Enabling personalized cancer medicine through analysis of gene-expression patterns
Laura J. van't Veer & René Bernards
Nature 452, 564–570
(3 April 2008); doi:10.1038/nature06915
| Summary | Full Text (HTML / PDF) |
review
Mining the plasma proteome for cancer biomarkers
Samir M. Hanash, Sharon J. Pitteri & Vitor M. Faca
Nature 452, 571–579
(3 April 2008); doi:10.1038/nature06916
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review
Imaging in the era of molecular oncology
Ralph Weissleder & Mikael J. Pittet
Nature 452, 580–589
(3 April 2008); doi:10.1038/nature06917
| Summary | Full Text (HTML / PDF) |
review
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
Jarl E. S. Wikberg & Felikss Mutulis
Nature Reviews Drug Discovery 7, 307–323
(April 2008); doi:10.1038/nrd2331
| Summary | Full Text (HTML / PDF) |
article
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
Shuang Chang, Steven M Bray, Zigang Li, Daniela C Zarnescu, Chuan He, Peng Jin & Stephen T Warren
Nature Chemical Biology 4, 256–263
(April 2008); doi:10.1038/nchembio.78
| Summary | Full Text (HTML / PDF) |
March
article
Genetics of gene expression and its effect on disease
Valur Emilsson et al.
Nature 452, 423–428
(27 March 2008); doi:10.1038/nature06758
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article
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen et al.
Nature 452, 429–435
(27 March 2008); doi:10.1038/nature06757
| Summary | Full Text (HTML / PDF) |
review
IgE in allergy and asthma today
Hannah J. Gould & Brian J. Sutton
Nature Reviews Immunology 8, 205–217
(March 2008); doi:10.1038/nri2273
| Summary | Full Text (HTML / PDF) |
article
The Notch pathway in podocytes plays a role in the development of glomerular disease
Thiruvur Niranjan et al.
Nature Medicine 14, 290–298
(March 2008); doi:10.1038/nm1731
| Summary | Full Text (HTML / PDF) |
news and views
Notch inhibition reverses kidney failure
Matthias Kretzler & Lisa Allred
Nature Medicine 14, 246–247
(March 2008); doi:10.1038/nm0308-246
| Summary | Full Text (HTML / PDF) |
article
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
Johann K Eberhart et al.
Nature Genetics 40, 290–298
(March 2008); doi:10.1038/ng.82
| Summary | Full Text (HTML / PDF) |
news and views
MicroRNAs in facial development
David E Clouthier
Nature Genetics 40, 268–269
(March 2008); doi:10.1038/ng0308-268
| Summary | Full Text (HTML / PDF) |
article
A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides
Gilbert Gallardo, Oliver M Schlüter & Thomas C Südhof
Nature Neuroscience 11, 301–308
(March 2008); doi:10.1038/nn2058
| Summary | Full Text (HTML / PDF) |
review
Interleukin 21: combination strategies for cancer therapy
Kresten Skak, Michael Kragh, Diana Hausman, Mark J. Smyth & Pallavur V. Sivakumar
Nature Reviews Drug Discovery 7, 231–240
(March 2008); doi:10.1038/nrd2482
| Summary | Full Text (HTML / PDF) |
review
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Deborah M. Muoio & Christopher B. Newgard
Nature Reviews Molecular Cell Biology 9, 193–205
(March 2008); doi:10.1038/nrm2327
| Summary | Full Text (HTML / PDF) |
review
DNA repair pathways as targets for cancer therapy
Thomas Helleday, Eva Petermann, Cecilia Lundin, Ben Hodgson & Ricky A. Sharma
Nature Reviews Cancer 8, 193–204
(March 2008); doi:10.1038/nrc2342
| Summary | Full Text (HTML / PDF) |
letter
Identification of a serotonin/glutamate receptor complex implicated in psychosis
Javier González-Maeso et al.
Nature 452, 93–97
(6 March 2008); doi:10.1038/nature06612
| Summary | Full Text (HTML / PDF) |
news and views
Neuroscience: A complex in psychosis
Solomon H. Snyder
Nature 452, 38–39
(6 March 2008); doi:10.1038/452038a
| Full Text (HTML / PDF) |
review
Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders
Gareth J. Sanger & Kevin Lee
Nature Reviews Drug Discovery 7, 241–254
(March 2008); doi:10.1038/nrd2444
| Summary | Full Text (HTML / PDF) |
February
article
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
May H. Han et al.
Nature 451, 1076–1081
(28 February 2008); doi:10.1038/nature06559
| Summary | Full Text (HTML / PDF) |
letter
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
Nature 451, 1111–1115
(28 February 2008); doi:10.1038/nature06548
| Summary | Full Text (HTML / PDF) |
letter
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai et al.
Nature 451, 1116–1120
(28 February 2008); doi:10.1038/nature06633
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news and views
Cancer: Crossing over to drug resistance
David M. Livingston & Daniel P. Silver
Nature 451, 1066–1067
(28 February 2008); doi:10.1038/4511066a
| Full Text (HTML / PDF) |
review
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Claudiu T. Supuran
Nature Reviews Drug Discovery 7, 168–181
(February 2008); doi:10.1038/nrd2467
| Summary | Full Text (HTML / PDF) |
review
Translating molecular discoveries into new therapies for atherosclerosis
Daniel J. Rader & Alan Daugherty
Nature 451, 904–913
(21 February 2008); doi:10.1038/nature06796
| Summary | Full Text (HTML / PDF) |
review
Triggers, targets and treatments for thrombosis
Nigel Mackman
Nature 451, 914–918
(21 February 2008); doi:10.1038/nature06797
| Summary | Full Text (HTML / PDF) |
review
Tackling heart failure in the twenty-first century
James O. Mudd & David A. Kass
Nature 451, 919–928
(21 February 2008); doi:10.1038/nature06798
| Summary | Full Text (HTML / PDF) |
review
The developmental genetics of congenital heart disease
Benoit G. Bruneau
Nature 451, 943–948
(21 February 2008); doi:10.1038/nature06801
| Summary | Full Text (HTML / PDF) |
progress
The search for new cardiovascular biomarkers
Robert E. Gerszten & Thomas J. Wang
Nature 451, 949–952
(21 February 2008); doi:10.1038/nature06802
| Summary | Full Text (HTML / PDF) |
letter
Oxidative damage-induced inflammation initiates age-related macular degeneration
Joe G Hollyfield et al.
Nature Medicine 14, 194–198
(February 2008); doi:10.1038/nm1709
| Summary | Full Text (HTML / PDF) |
letter
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
Natalie C Jones et al.
Nature Medicine 14, 125–133
(February 2008); doi:10.1038/nm1725
| Summary | Full Text (HTML / PDF) |
news and views
Saving face: rescuing a craniofacial birth defect
Sonja Jane McKeown & Marianne Bronner-Fraser
Nature Medicine 14, 115–116
(February 2008); doi:10.1038/nm0208-115
| Summary | Full Text (HTML / PDF) |
review
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Jon O. Lundberg, Eddie Weitzberg & Mark T. Gladwin
Nature Reviews Drug Discovery 7, 156–167
(February 2008); doi:10.1038/nrd2466
| Summary | Full Text (HTML / PDF) |
letter
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ken J. Ishii et al.
Nature 451, 725–729
(7 February 2008); doi:10.1038/nature06537
| Summary | Full Text (HTML / PDF) |
review
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
Anthony G. Letai
Nature Reviews Cancer 8, 121–132
(February 2008); doi:10.1038/nrc2297
| Summary | Full Text (HTML / PDF) |
review
Lipid signalling in disease
Matthias P. Wymann & Roger Schneiter
Nature Reviews Molecular Cell Biology 9, 162–176
(February 2008); doi:10.1038/nrm2335
| Summary | Full Text (HTML / PDF) |
brief communication
Site selectivity of platinum anticancer therapeutics
Bin Wu, Peter Dröge & Curt A Davey
Nature Chemical Biology 4, 110–112
(February 2008); doi:10.1038/nchembio.2007.58
| Summary | Full Text (HTML / PDF) |
January
letter
G12–G13–LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Angela Wirth et al.
Nature Medicine 14, 64–68
(January 2008); doi:10.1038/nm1666
| Summary | Full Text (HTML / PDF) |
news and views
Salt abuse: the path to hypertension
Wilhelm Schoner
Nature Medicine 14, 16–17
(January 2008); doi:10.1038/nm0108-16
| Summary | Full Text (HTML / PDF) |
letter
A quantitative analysis of kinase inhibitor selectivity
Mazen W Karaman et al.
Nature Biotechnology 26, 127–132
(January 2008); doi:10.1038/nbt1358
| Summary | Full Text (HTML / PDF) |
perspective
Protein therapeutics: a summary and pharmacological classification
Benjamin Leader, Quentin J. Baca & David E. Golan
Nature Reviews Drug Discovery 7, 21–39
(January 2008); doi:10.1038/nrd2399
| Summary | Full Text (HTML / PDF) |
letter
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
Maksim V. Plikus et al.
Nature 451, 340–344
(17 January 2008); doi:10.1038/nature06457
| Summary | Full Text (HTML / PDF) |
letter
Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345–349
(17 January 2008); doi:10.1038/nature06489
| Summary | Full Text (HTML / PDF) |
article
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
Thirumalai R Ramalingam et al.
Nature Immunology 9, 25–33
(January 2008); doi:10.1038/ni1544
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review
The expectant brain: adapting for motherhood
Paula J. Brunton & John A. Russell
Nature Reviews Neuroscience 9, 11–25
(January 2008); doi:10.1038/nrn2280
| Summary | Full Text (HTML / PDF) |
review
Regulation of iron acquisition and storage: consequences for iron-linked disorders
Ivana De Domenico, Diane McVey Ward & Jerry Kaplan
Nature Reviews Molecular Cell Biology 9, 72–81
(January 2008); doi:10.1038/nrm2295
| Summary | Full Text (HTML / PDF) |
article
Modification of kidney barrier function by the urokinase receptor
Changli Wei et al.
Nature Medicine 14, 55–63
(January 2008); doi:10.1038/nm1696
| Summary | Full Text (HTML / PDF) |
review
From inflammation to sickness and depression: when the immune system subjugates the brain
Robert Dantzer, Jason C. O'Connor, Gregory G. Freund, Rodney W. Johnson & Keith W. Kelley
Nature Reviews Neuroscience 9, 46–56
(January 2008); doi:10.1038/nrn2297
| Summary | Full Text (HTML / PDF) |
review
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
Kishor M. Wasan, Dion R. Brocks, Stephen D. Lee, Kristina Sachs-Barrable & Sheila J. Thornton
Nature Reviews Drug Discovery 7, 84–99
(January 2008); doi:10.1038/nrd2353
| Summary | Full Text (HTML / PDF) |
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