Research library: Clinical / Drug discovery
2008:
| December
| November
| October
| September
| August
| July
| June
| May
| April
| March
| February
| January
Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2009
December
article
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation
Rihab Nasr et al.
Nature Medicine 14, 1333–1342
(December 2008); doi:10.1038/nm.1891
| Summary | Full Text (HTML / PDF) |
letter
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A Engelman et al.
Nature Medicine 14, 1351–1356
(December 2008); doi:10.1038/nm.1890
| Summary | Full Text (HTML / PDF) |
news and views
Targeting RAS and PI3K in lung cancer
Julian Downward
Nature Medicine 14, 1315–1316
(December 2008); doi:10.1038/nm1208-1315
| Full Text (HTML / PDF) |
review
From bench to bedside: stealth of enteroinvasive pathogens
Renée M. Tsolis, Glenn M. Young, Jay V. Solnick & Andreas J. Bäumler
Nature Reviews Microbiology 6, 883–892
(December 2008); doi:10.1038/nrmicro2012
| Summary | Full Text (HTML / PDF) |
review
Viral evasion and subversion of pattern-recognition receptor signalling
Andrew G. Bowie & Leonie Unterholzner
Nature Reviews Immunology 8, 911–922
(December 2008); doi:10.1038/nri2436
| Summary | Full Text (HTML / PDF) |
article
Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex
Xue Jun Liu et al.
Nature Medicine 14, 1325–1332
(December 2008); doi:10.1038/nm.1883
| Summary | Full Text (HTML / PDF) |
news and views
Breaking the pain connection
Catherine J Pallen
Nature Medicine 14, 1313–1315
(December 2008); doi:10.1038/nm1208-1313
| Full Text (HTML / PDF) |
letter
Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases
M Melina Soares, Steven W King & Philip E Thorpe
Nature Medicine 14, 1357–1362
(December 2008); doi:10.1038/nm.1885
| Summary | Full Text (HTML / PDF) |
letter
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
Shigeru Shibata et al.
Nature Medicine 14, 1370–1376
(December 2008); doi:10.1038/nm.1879
| Summary | Full Text (HTML / PDF) |
review
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
Anwesha Dey, Vinay Tergaonkar & David P. Lane
Nature Reviews Drug Discovery 7, 1031–1040
(December 2008); doi:10.1038/nrd2759
| Summary | Full Text (HTML / PDF) |
review
Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
Avi Ashkenazi
Nature Reviews Drug Discovery 7, 1001–1012
(December 2008); doi:10.1038/nrd2637
| Summary | Full Text (HTML / PDF) |
perspective
Immunotherapy of autoimmunity and cancer: the penalty for success
Rachel R. Caspi
Nature Reviews Immunology 8, 970–976
(December 2008); doi:10.1038/nri2438
| Summary | Full Text (HTML / PDF) |
review
Insulin and insulin-like growth factor signalling in neoplasia
Michael Pollak
Nature Reviews Cancer 8, 915–928
(December 2008); doi:10.1038/nrc2536
| Summary | Full Text (HTML / PDF) |
review
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim, Wenjie Xu & John C. Reed
Nature Reviews Drug Discovery 7, 1013–1030
(December 2008); doi:10.1038/nrd2755
| Summary | Full Text (HTML / PDF) |
review
BCL-2 family antagonists for cancer therapy
Guillaume Lessene, Peter E. Czabotar & Peter M. Colman
Nature Reviews Drug Discovery 7, 989–1000
(December 2008); doi:10.1038/nrd2658
| Summary | Full Text (HTML / PDF) |
November
article
5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Hendrik Poeck et al.
Nature Medicine 14, 1256–1263
(November 2008); doi:10.1038/nm.1887
| Summary | Full Text (HTML / PDF) |
news and views
RIG-ing an antitumor response
Fabio Petrocca & Judy Lieberman
Nature Medicine 14, 1152–1153
(November 2008); doi:10.1038/nm1108-1152
| Full Text (HTML / PDF) |
article
Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
Manuel A Friese et al.
Nature Medicine 14, 1227–1235
(November 2008); doi:10.1038/nm.1881
| Summary | Full Text (HTML / PDF) |
news and views
HLA class I: friend and foe of multiple sclerosis
Roland Martin
Nature Medicine 14, 1150–1151
(November 2008); doi:10.1038/nm1108-1150
| Full Text (HTML / PDF) |
review
Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection
Norberto Perico, Ariela Benigni & Giuseppe Remuzzi
Nature Reviews Drug Discovery 7, 936–953
(November 2008); doi:10.1038/nrd2685
| Summary | Full Text (HTML / PDF) |
article
Deconstructing voltage sensor function and pharmacology in sodium channels
Frank Bosmans, Marie-France Martin-Eauclaire & Kenton J. Swartz
Nature 456, 202–208
(13 November 2008); doi:10.1038/nature07473
| Summary | Full Text (HTML / PDF) |
news and views
Ion channels: The voltage-sensor quartet
J. R. Bankston & R. S. Kass
Nature 456, 183–185
(November 2008); doi:10.1038/456183a
| Full Text (HTML / PDF) |
article
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
Masatoshi Jinnin et al.
Nature Medicine 14, 1236–1246
(November 2008); doi:10.1038/nm.1877
| Summary | Full Text (HTML / PDF) |
news and views
Healing hemangiomas
Lena Claesson-Welsh
Nature Medicine 14, 1147–1148
(November 2008); doi:10.1038/nm1108-1147
| Full Text (HTML / PDF) |
perspective
VEGF-A splicing: the key to anti-angiogenic therapeutics?
Steven J. Harper & David O. Bates
Nature Reviews Cancer 8, 880–887
(November 2008); doi:10.1038/nrc2505
| Summary | Full Text (HTML / PDF) |
review
Metabolic syndrome: from epidemiology to systems biology
Aldons J. Lusis, Alan D. Attie & Karen Reue
Nature Reviews Genetics 9, 819–830
(November 2008); doi:10.1038/nrg2468
| Summary | Full Text (HTML / PDF) |
review
Novel therapeutic applications of cardiac glycosides
Ioannis Prassas & Eleftherios P. Diamandis
Nature Reviews Drug Discovery 7, 926–935
(November 2008); doi:10.1038/nrd2682
| Summary | Full Text (HTML / PDF) |
October
article
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille & Michael L. Cleary
Nature 455, 1205–1209
(30 October 2008); doi:10.1038/nature07284
| Summary | Full Text (HTML / PDF) |
letter
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson & James A. Huntington
Nature 455, 1255–1258
(30 October 2008); doi:10.1038/nature07394
| Summary | Full Text (HTML / PDF) |
news and views
Structural biology: Serpins' mystery solved
James C. Whisstock & Stephen P. Bottomley
Nature 10, 1189–1190
(30 October 2008); doi:10.1038/4551189a
| Full Text (HTML / PDF) |
article
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Przemyslaw Sapieha et al.
Nature Medicine 14, 1067–1076
(October 2008); doi:10.1038/nm.1873
| Summary | Full Text (HTML / PDF) |
review
CART peptides: regulators of body weight, reward and other functions
G. Rogge, D. Jones, G. W. Hubert, Y. Lin & M. J. Kuhar
Nature Reviews Neuroscience 9, 747–758
(October 2008); doi:10.1038/nrn2493
| Summary | Full Text (HTML / PDF) |
review
The IL-33/ST2 pathway: therapeutic target and novel biomarker
Rahul Kakkar & Richard T. Lee
Nature Reviews Drug Discovery 7, 827–840
(October 2008); doi:10.1038/nrd2660
| Summary | Full Text (HTML / PDF) |
article
Activation of tyrosine kinases by mutation of the gatekeeper threonine
Mohammad Azam, Markus A Seeliger, Nathanael S Gray, John Kuriyan & George Q Daley
Nature Structural & Molecular Biology 15, 1109–1118
(October 2008); doi:10.1038/nsmb.1486
| Summary | Full Text (HTML / PDF) |
letter
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
Xian-Ping Dong et al.
Nature 455, 992–996
(16 October 2008); doi:10.1038/nature07311
| Summary | Full Text (HTML / PDF) |
review
Harmful molecular mechanisms in sepsis
Daniel Rittirsch, Michael A. Flierl & Peter A. Ward
Nature Reviews Immunology 8, 776–787
(October 2008); doi:10.1038/nri2402
| Summary | Full Text (HTML / PDF) |
review
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Joseph S. Takahashi, Hee-Kyung Hong, Caroline H. Ko & Erin L. McDearmon
Nature Reviews Genetics 9, 764–775
(October 2008); doi:10.1038/nrg2430
| Summary | Full Text (HTML / PDF) |
review
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Lars Bertram & Rudolph E. Tanzi
Nature Reviews Neuroscience 9, 768–778
(October 2008); doi:10.1038/nrn2494
| Summary | Full Text (HTML / PDF) |
review
Sirtuins — novel therapeutic targets to treat age-associated diseases
Siva Lavu, Olivier Boss, Peter J. Elliott & Philip D. Lambert
Nature Reviews Drug Discovery 7, 841–853
(October 2008); doi:10.1038/nrd2665
| Summary | Full Text (HTML / PDF) |
article
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
Robert L Wilensky et al.
Nature Medicine 14, 1059–1066
(October 2008); doi:10.1038/nm.1870
| Summary | Full Text (HTML / PDF) |
news and views
Getting to the core of atherosclerosis
Nancy R Webb
Nature Medicine 14, 1015–1016
(October 2008); doi:10.1038/nm1008-1015
| Full Text (HTML / PDF) |
article
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Qiao Zhou, Juliana Brown, Andrew Kanarek, Jayaraj Rajagopal & Douglas A. Melton
Nature 455, 627–632
(2 October 2008); doi:10.1038/nature07314
| Summary | Full Text (HTML / PDF) |
news and views
Regenerative medicine: Short cut to cell replacement
Robert Blelloch
Nature 455, 604–605
(2 October 2008); doi:10.1038/455604a;
| Full Text (HTML / PDF) |
review
The TRAIL apoptotic pathway in cancer onset, progression and therapy
Ricky W. Johnstone, Ailsa J. Frew & Mark J. Smyth
Nature Reviews Cancer 8, 782–798
(October 2008); doi:10.1038/nrc2465
| Summary | Full Text (HTML / PDF) |
September
article
The kinase p38α serves cell type—specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
Chun Kim et al.
Nature Immunology 9, 1019–1027
(September 2008); doi:10.1038/ni.1640
| Summary | Full Text (HTML / PDF) |
letter
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption
Eun-Ju Chang et al.
Nature Medicine 14, 966–972
(September 2008); doi:10.1038/nm.1860
| Summary | Full Text (HTML / PDF) |
review
Molecular mechanisms of L-DOPA-induced dyskinesia
Peter Jenner
Nature Reviews Neuroscience 9, 665–677
(September 2008); doi:10.1038/nrn2471
| Summary | Full Text (HTML / PDF) |
review
Targeting of tetraspanin proteins — potential benefits and strategies
Martin E. Hemler
Nature Reviews Drug Discovery 7, 747–758
(September 2008); doi:10.1038/nrd2659
| Summary | Full Text (HTML / PDF) |
letter
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
Nature 455, 406–410
(18 September 2008); doi:10.1038/nature07275
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Hedgehog's other great trick
Tom Curran & Jessica M. Y. Ng
Nature 455, 293–294
(18 September 2008); doi:10.1038/455293a
| Full Text (HTML / PDF) |
letter
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation
Carine Le Goff et al.
Nature Genetics 40, 1119–1123
(September 2008); doi:10.1038/ng.199
| Summary | Full Text (HTML / PDF) |
review
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
György Haskó, Joel Linden, Bruce Cronstein & Pál Pacher
Nature Reviews Drug Discovery 7, 759–770
(September 2008); doi:10.1038/nrd2638
| Summary | Full Text (HTML / PDF) |
article
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
Christian Faul et al.
Nature Medicine 14, 931–938
(September 2008); doi:10.1038/nm.1857
| Summary | Full Text (HTML / PDF) |
letter
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling
Steven Hoseong Yang et al.
Nature Genetics 40, 1130–1135
(September 2008); doi:10.1038/ng.192
| Summary | Full Text (HTML / PDF) |
news and views
Hedgehog in Wnterland
Dennis Roop & Rune Toftgård
Nature Genetics 40, 1040–1041
(September 2008); doi:10.1038/ng0908-1040
| Full Text (HTML / PDF) |
article
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
Robert J Snelgrove et al.
Nature Immunology 9, 1074–1083
(September 2008); doi:10.1038/ni.1637
| Summary | Full Text (HTML / PDF) |
news and views
The CD200-CD200R axis in local control of lung inflammation
Patrick G Holt & Deborah H Strickland
Nature Immunology 9, 1011–1013
(September 2008); doi:10.1038/ni0908-1011
| Full Text (HTML / PDF) |
August
article
Misfolded proteins partition between two distinct quality control compartments
Daniel Kaganovich, Ron Kopito & Judith Frydman
Nature 454, 1088–1095
(28 August 2008); doi:10.1038/nature07195
| Summary | Full Text (HTML / PDF) |
review
Puzzles, promises and a cure for ageing
Jan Vijg & Judith Campisi
Nature 454, 1065–1071
(28 August 2008); doi:10.1038/nature07216
| Summary | Full Text (HTML / PDF) |
letter
Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
Cissy C Zhou et al.
Nature Medicine 14, 855–862
(August 2008); doi:10.1038/nm.1856
| Summary | Full Text (HTML / PDF) |
review
Modes of resistance to anti-angiogenic therapy
Gabriele Bergers & Douglas Hanahan
Nature Reviews Cancer 8, 592–603
(August 2008); doi:10.1038/nrc2442
| Summary | Full Text (HTML / PDF) |
perspective
How can we realize the promise of personalized antidepressant medicines?
Florian Holsboer
Nature Reviews Neuroscience 9, 638–646
(August 2008); doi:10.1038/nrn2453
| Summary | Full Text (HTML / PDF) |
review
Mechanisms of microbial traversal of the blood–brain barrier
Kwang Sik Kim
Nature Reviews Microbiology 6, 625–634
(August 2008); doi:10.1038/nrmicro1952
| Summary | Full Text (HTML / PDF) |
letter
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
Sakura Saburi et al.
Nature Genetics 40, 1010–1015
(August 2008); doi:10.1038/ng.179
| Summary | Full Text (HTML / PDF) |
perspective
Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment
Jinhai Wang et al.
Nature Biotechnology 26, 901–908
(August 2008); doi:10.1038/nbt.1484
| Summary | Full Text (HTML / PDF) |
article
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Scott A Yuzwa et al.
Nature Chemical Biology 4, 483–490
(August 2008); doi:10.1038/nchembio.96
| Summary | Full Text (HTML / PDF) |
news and views
Turning down tau phosphorylation
Peter M Fischer
Nature Chemical Biology 4, 448–449
(August 2008); doi:10.1038/nchembio0808-448
| Full Text (HTML / PDF) |
letter
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Dan Ehninger et al.
Nature Medicine 14, 843–848
doi:10.1038/nm1788
| Summary | Full Text (HTML / PDF) |
letter
A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease
Xiaogang Li et al.
Nature Medicine 14, 863–868
doi:10.1038/nm1783
| Summary | Full Text (HTML / PDF) |
article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath R Junutula et al.
Nature Biotechnology 26, 925–932
doi:10.1038/nbt.1480
| Summary | Full Text (HTML / PDF) |
news and views
Antibody-drug conjugates ace the tolerability test
Nitin K Damle
Nature Biotechnology 26, 884–885
(August 2008); doi:10.1038/nbt0808-884
| Full Text (HTML / PDF) |
review
VEGF-targeted therapy: mechanisms of anti-tumour activity
Lee M. Ellis & Daniel J. Hicklin
Nature Reviews Cancer 8, 579–591
(August 2008); doi:10.1038/nrc2403
| Summary | Full Text (HTML / PDF) |
July
review
Origin and physiological roles of inflammation
Ruslan Medzhitov
Nature 454, 428–435
(24 July 2008); doi:10.1038/nature07201
| Summary | Full Text (HTML / PDF) |
review
The development of allergic inflammation
Stephen J. Galli, Mindy Tsai & Adrian M. Piliponsky
Nature 454, 445–454
(24 July 2008); doi:10.1038/nature07204
| Summary | Full Text (HTML / PDF) |
letter
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
Ignacio Varela et al.
Nature Medicine 14, 767–772
(July 2008); doi:10.1038/nm1786
| Summary | Full Text (HTML / PDF) |
news and views
Rejuvenating premature aging
Eran Meshorer & Yosef Gruenbaum
Nature Medicine 14, 713–715
(July 2008); doi:10.1038/nm0708-713
| Full Text (HTML / PDF) |
perspective
Exploring the role of cancer stem cells in radioresistance
Michael Baumann, Mechthild Krause & Richard Hill
Nature Reviews Cancer 8, 545–554
(July 2008); doi:10.1038/nrc2419
| Summary | Full Text (HTML / PDF) |
article
An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Ofra Benny et al.
Nature Biotechnology 26, 799–807
(July 2008); doi:10.1038/nbt1415
| Summary | Full Text (HTML / PDF) |
news and views
Hitting the mother lode of tumor angiogenesis
Daylon James, Sina Rabbany & Shahin Rafii
Nature Biotechnology 26, 769–770
(July 2008); doi:10.1038/nbt0708-769
| Full Text (HTML / PDF) |
review
Molecular imaging in drug development
Jürgen K. Willmann, Nicholas van Bruggen, Ludger M. Dinkelborg & Sanjiv S. Gambhir
Nature Reviews Drug Discovery 7, 591–607
(July 2008); doi:10.1038/nrd2290
| Summary | Full Text (HTML / PDF) |
article
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
Enming J Su et al.
Nature Medicine 14, 731–737
(July 2008); doi:10.1038/nm1787
| Summary | Full Text (HTML / PDF) |
news and views
Imatinib buys time for brain after stroke
Peter Rieckmann
Nature Medicine 14, 712–713
(July 2008); doi:10.1038/nm0708-712
| Full Text (HTML / PDF) |
research
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1
Yukihiko Aikawa et al.
Nature Biotechnology 26, 817–823
(July 2008); doi:10.1038/nbt1412
| Summary | Full Text (HTML / PDF) |
review
Purinergic signalling and disorders of the central nervous system
Geoffrey Burnstock
Nature Reviews Drug Discovery 7, 575–590
(July 2008); doi:10.1038/nrd2605
| Summary | Full Text (HTML / PDF) |
review
Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded
Roberto Cattaneo, Tanner Miest, Elena V. Shashkova & Michael A. Barry
Nature Reviews Microbiology 6, 529–540
(July 2008); doi:10.1038/nrmicro1927
| Summary | Full Text (HTML / PDF) |
June
article
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
Edy Y Kim et al.
Nature Medicine 14, 633–640
(June 2008); doi:10.1038/nm1770
| Summary | Full Text (HTML / PDF) |
news and views
Lung NKT cell commotion takes your breath away
Sebastian Joyce & Luc Van Kaer
Nature Medicine 14, 609–610
(June 2008); doi:10.1038/nm0608-609
| Full Text (HTML / PDF) |
letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
| Summary | Full Text (HTML / PDF) |
review
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
Nature Reviews Neuroscience 9, 437–452
(June 2008); doi:10.1038/nrn2392
| Summary | Full Text (HTML / PDF) |
review
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
Masato Furuhashi & Gökhan S. Hotamisligil
Nature Reviews Drug Discovery 7, 489–503
(June 2008); doi:10.1038/nrd2589
| Summary | Full Text (HTML / PDF) |
article
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
Alessia Montagnoli et al.
Nature Chemical Biology 4, 357–365
(June 2008); doi:10.1038/nchembio.90
| Summary | Full Text (HTML / PDF) |
news and views
Stopping replication, at the beginning
Peter K Jackson
Nature Chemical Biology 4, 331–332
(June 2008); doi:10.1038/nchembio0608-331
| Full Text (HTML / PDF) |
letter
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia
Keizo Kanasaki et al.
Nature 453, 1117–1121
(19 June 2008); doi:10.1038/nature06951
| Summary | Full Text (HTML / PDF) |
letter
Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology
Terrence Town et al.
Nature Medicine 14, 681–687
(June 2008); doi:10.1038/nm1781
| Summary | Full Text (HTML / PDF) |
review
Drug development of MET inhibitors: targeting oncogene addiction and expedience
Paolo M. Comoglio, Silvia Giordano & Livio Trusolino
Nature Reviews Drug Discovery 7, 504–516
(June 2008); doi:10.1038/nrd2530
| Summary | Full Text (HTML / PDF) |
letter
Substrate-targeting γ-secretase modulators
Thomas L. Kukar et al.
Nature 453, 925–929
(12 June 2008); doi:10.1038/nature07055
| Summary | Full Text (HTML / PDF) |
news and views
Biochemistry: Molecular cloaking devices
Thomas Kodadek
Nature 453, 861–862
(12 June 2008); doi:10.1038/453861a
| Summary | Full Text (HTML / PDF) |
review
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Lin Mei & Wen-Cheng Xiong
Nature Reviews Neuroscience 9, 437–452
(June 2008); doi:10.1038/nrn2392
| Summary | Full Text (HTML / PDF) |
May
letter
CLEC5A is critical for dengue-virus-induced lethal disease
Szu-Ting Chen et al.
Nature 453, 672–676
(29 May 2008); doi:10.1038/nature07013
| Summary | Full Text (HTML / PDF) |
article
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure
Stephen B Liggett et al.
Nature Medicine 14, 510–517
(May 2008); doi:10.1038/nm1750
| Summary | Full Text (HTML / PDF) |
news and views
β-adrenergic signaling in heart failure—adapt or die
Thomas Eschenhagen
Nature Medicine 14, 485–487
(May 2008); doi:10.1038/nm0508-485
| Summary | Full Text (HTML / PDF) |
perspective
Wnt signalling and its impact on development and cancer
Alexandra Klaus & Walter Birchmeier
Nature Reviews Cancer 8, 387–398
(May 2008); doi:10.1038/nrc2389
| Summary | Full Text (HTML / PDF) |
article
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma
Nandini Krishnamoorthy et al.
Nature Medicine 14, 565–573
(May 2008); doi:10.1038/nm1766
| Summary | Full Text (HTML / PDF) |
news and views
Dust mites' dirty dealings with dendritic cells
Dean Sheppard
Nature Medicine 14, 487–488
(May 2008); doi:10.1038/nm0508-487
| Summary | Full Text (HTML / PDF) |
review
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Klaus Pantel, Ruud H. Brakenhoff & Burkhard Brandt
Nature Reviews Cancer 8, 329–340
(May 2008); doi:10.1038/nrc2375
| Summary | Full Text (HTML / PDF) |
article
Functional roles for C5a receptors in sepsis
Daniel Rittirsch et al.
Nature Medicine 14, 551–557
(May 2008); doi:10.1038/nm1753
| Summary | Full Text (HTML / PDF) |
article
Stromal gene expression predicts clinical outcome in breast cancer
Greg Finak et al.
Nature Medicine 14, 518–527
(May 2008); doi:10.1038/nm1764
| Summary | Full Text (HTML / PDF) |
review
Getting to the stem of chronic myeloid leukaemia
Michael Savona & Moshe Talpaz
Nature Reviews Cancer 8, 341–350
(May 2008); doi:10.1038/nrc2368
| Summary | Full Text (HTML / PDF) |
article
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
Nature Chemical Biology 5, 295–305
(May 2008); doi:10.1038/nchembio.79
| Summary | Full Text (HTML / PDF) |
article
CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells
Sylvain Perruche, Pin Zhang, Yongzhong Liu, Philippe Saas, Jeffrey A Bluestone & WanJun Chen
Nature Medicine 14, 528–535
(May 2008); doi:10.1038/nm1749
| Summary | Full Text (HTML / PDF) |
perspective
A new penumbra: transitioning from injury into repair after stroke
Eng H Lo
Nature Medicine 14, 497–500
(May 2008); doi:10.1038/nm1735
| Summary | Full Text (HTML / PDF) |
letter
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
Jacques Behmoaras et al.
Nature Genetics 40, 553–559
(May 2008); doi:10.1038/ng.137
| Summary | Full Text (HTML / PDF) |
review
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Nicholas P. Franks
Nature Reviews Neuroscience 9, 370–386
(May 2008); doi:10.1038/nrn2372
| Summary | Full Text (HTML / PDF) |
review
The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting
Jeffrey A. Winkles
Nature Reviews Drug Discovery 7, 411–425
(May 2008); doi:10.1038/nrd2488
| Summary | Full Text (HTML / PDF) |
April
review
Structural diversity of G protein-coupled receptors and significance for drug discovery
Malin C. Lagerström & Helgi B. Schiöth
Nature Reviews Drug Discovery 7, 339–357
(April 2008); doi:10.1038/nrd2518
| Summary | Full Text (HTML / PDF) |
review
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
Jarl E. S. Wikberg & Felikss Mutulis
Nature Reviews Drug Discovery 7, 307–323
(April 2008); doi:10.1038/nrd2331
| Summary | Full Text (HTML / PDF) |
review
Cell-division inhibitors: new insights for future antibiotics
Rowena L. Lock & Elizabeth J. Harry
Nature Reviews Drug Discovery 7, 324–338
(April 2008); doi:10.1038/nrd2510
| Summary | Full Text (HTML / PDF) |
article
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
Janghoo Lim et al.
Nature 452, 713–718
(10 April 2008); doi:10.1038/nature06731
| Summary | Full Text (HTML / PDF) |
news and views
Neurodegeneration: A question of balance
Leslie Michels Thompson
Nature 452, 707–708
(10 April 2008); doi:10.1038/452707a
| Full Text (HTML / PDF) |
letter
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Michael Groll et al.
Nature 452, 755–758
(10 April 2008); doi:10.1038/nature06782
| Summary | Full Text (HTML / PDF) |
letter
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Joshua D. Milner et al.
Nature 452, 773–776
(10 April 2008); doi:10.1038/nature06764
| Summary | Full Text (HTML / PDF) |
perspective
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
Rakesh K. Jain
Nature Reviews Cancer 8, 309–316
(April 2008); doi:10.1038/nrc2346
| Summary | Full Text (HTML / PDF) |
review
High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev & Robert Arias
Nature Reviews Drug Discovery 7, 358–368
(April 2008); doi:10.1038/nrd2552
| Summary | Full Text (HTML / PDF) |
review
The cancer biomarker problem
Charles L. Sawyers
Nature 452, 548–552
(3 April 2008); doi:10.1038/nature06913
| Summary | Full Text (HTML / PDF) |
review
Translating insights from the cancer genome into clinical practice
Lynda Chin & Joe W. Gray
Nature 452, 553–552
(3 April 2008); doi:10.1038/nature06914
| Summary | Full Text (HTML / PDF) |
review
Enabling personalized cancer medicine through analysis of gene-expression patterns
Laura J. van't Veer & René Bernards
Nature 452, 564–570
(3 April 2008); doi:10.1038/nature06915
| Summary | Full Text (HTML / PDF) |
review
Mining the plasma proteome for cancer biomarkers
Samir M. Hanash, Sharon J. Pitteri & Vitor M. Faca
Nature 452, 571–579
(3 April 2008); doi:10.1038/nature06916
| Summary | Full Text (HTML / PDF) |
review
Imaging in the era of molecular oncology
Ralph Weissleder & Mikael J. Pittet
Nature 452, 580–589
(3 April 2008); doi:10.1038/nature06917
| Summary | Full Text (HTML / PDF) |
review
Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction
Jarl E. S. Wikberg & Felikss Mutulis
Nature Reviews Drug Discovery 7, 307–323
(April 2008); doi:10.1038/nrd2331
| Summary | Full Text (HTML / PDF) |
article
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
Shuang Chang, Steven M Bray, Zigang Li, Daniela C Zarnescu, Chuan He, Peng Jin & Stephen T Warren
Nature Chemical Biology 4, 256–263
(April 2008); doi:10.1038/nchembio.78
| Summary | Full Text (HTML / PDF) |
March
article
Genetics of gene expression and its effect on disease
Valur Emilsson et al.
Nature 452, 423–428
(27 March 2008); doi:10.1038/nature06758
| Summary | Full Text (HTML / PDF) |
article
Variations in DNA elucidate molecular networks that cause disease
Yanqing Chen et al.
Nature 452, 429–435
(27 March 2008); doi:10.1038/nature06757
| Summary | Full Text (HTML / PDF) |
review
IgE in allergy and asthma today
Hannah J. Gould & Brian J. Sutton
Nature Reviews Immunology 8, 205–217
(March 2008); doi:10.1038/nri2273
| Summary | Full Text (HTML / PDF) |
article
The Notch pathway in podocytes plays a role in the development of glomerular disease
Thiruvur Niranjan et al.
Nature Medicine 14, 290–298
(March 2008); doi:10.1038/nm1731
| Summary | Full Text (HTML / PDF) |
news and views
Notch inhibition reverses kidney failure
Matthias Kretzler & Lisa Allred
Nature Medicine 14, 246–247
(March 2008); doi:10.1038/nm0308-246
| Summary | Full Text (HTML / PDF) |
article
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
Johann K Eberhart et al.
Nature Genetics 40, 290–298
(March 2008); doi:10.1038/ng.82
| Summary | Full Text (HTML / PDF) |
news and views
MicroRNAs in facial development
David E Clouthier
Nature Genetics 40, 268–269
(March 2008); doi:10.1038/ng0308-268
| Summary | Full Text (HTML / PDF) |
article
A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides
Gilbert Gallardo, Oliver M Schlüter & Thomas C Südhof
Nature Neuroscience 11, 301–308
(March 2008); doi:10.1038/nn2058
| Summary | Full Text (HTML / PDF) |
review
Interleukin 21: combination strategies for cancer therapy
Kresten Skak, Michael Kragh, Diana Hausman, Mark J. Smyth & Pallavur V. Sivakumar
Nature Reviews Drug Discovery 7, 231–240
(March 2008); doi:10.1038/nrd2482
| Summary | Full Text (HTML / PDF) |
review
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Deborah M. Muoio & Christopher B. Newgard
Nature Reviews Molecular Cell Biology 9, 193–205
(March 2008); doi:10.1038/nrm2327
| Summary | Full Text (HTML / PDF) |
review
DNA repair pathways as targets for cancer therapy
Thomas Helleday, Eva Petermann, Cecilia Lundin, Ben Hodgson & Ricky A. Sharma
Nature Reviews Cancer 8, 193–204
(March 2008); doi:10.1038/nrc2342
| Summary | Full Text (HTML / PDF) |
letter
Identification of a serotonin/glutamate receptor complex implicated in psychosis
Javier González-Maeso et al.
Nature 452, 93–97
(6 March 2008); doi:10.1038/nature06612
| Summary | Full Text (HTML / PDF) |
news and views
Neuroscience: A complex in psychosis
Solomon H. Snyder
Nature 452, 38–39
(6 March 2008); doi:10.1038/452038a
| Full Text (HTML / PDF) |
review
Hormones of the gut–brain axis as targets for the treatment of upper gastrointestinal disorders
Gareth J. Sanger & Kevin Lee
Nature Reviews Drug Discovery 7, 241–254
(March 2008); doi:10.1038/nrd2444
| Summary | Full Text (HTML / PDF) |
February
article
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
May H. Han et al.
Nature 451, 1076–1081
(28 February 2008); doi:10.1038/nature06559
| Summary | Full Text (HTML / PDF) |
letter
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
Nature 451, 1111–1115
(28 February 2008); doi:10.1038/nature06548
| Summary | Full Text (HTML / PDF) |
letter
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai et al.
Nature 451, 1116–1120
(28 February 2008); doi:10.1038/nature06633
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: Crossing over to drug resistance
David M. Livingston & Daniel P. Silver
Nature 451, 1066–1067
(28 February 2008); doi:10.1038/4511066a
| Full Text (HTML / PDF) |
review
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Claudiu T. Supuran
Nature Reviews Drug Discovery 7, 168–181
(February 2008); doi:10.1038/nrd2467
| Summary | Full Text (HTML / PDF) |
review
Translating molecular discoveries into new therapies for atherosclerosis
Daniel J. Rader & Alan Daugherty
Nature 451, 904–913
(21 February 2008); doi:10.1038/nature06796
| Summary | Full Text (HTML / PDF) |
review
Triggers, targets and treatments for thrombosis
Nigel Mackman
Nature 451, 914–918
(21 February 2008); doi:10.1038/nature06797
| Summary | Full Text (HTML / PDF) |
review
Tackling heart failure in the twenty-first century
James O. Mudd & David A. Kass
Nature 451, 919–928
(21 February 2008); doi:10.1038/nature06798
| Summary | Full Text (HTML / PDF) |
review
The developmental genetics of congenital heart disease
Benoit G. Bruneau
Nature 451, 943–948
(21 February 2008); doi:10.1038/nature06801
| Summary | Full Text (HTML / PDF) |
progress
The search for new cardiovascular biomarkers
Robert E. Gerszten & Thomas J. Wang
Nature 451, 949–952
(21 February 2008); doi:10.1038/nature06802
| Summary | Full Text (HTML / PDF) |
letter
Oxidative damage-induced inflammation initiates age-related macular degeneration
Joe G Hollyfield et al.
Nature Medicine 14, 194–198
(February 2008); doi:10.1038/nm1709
| Summary | Full Text (HTML / PDF) |
letter
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
Natalie C Jones et al.
Nature Medicine 14, 125–133
(February 2008); doi:10.1038/nm1725
| Summary | Full Text (HTML / PDF) |
news and views
Saving face: rescuing a craniofacial birth defect
Sonja Jane McKeown & Marianne Bronner-Fraser
Nature Medicine 14, 115–116
(February 2008); doi:10.1038/nm0208-115
| Summary | Full Text (HTML / PDF) |
review
The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics
Jon O. Lundberg, Eddie Weitzberg & Mark T. Gladwin
Nature Reviews Drug Discovery 7, 156–167
(February 2008); doi:10.1038/nrd2466
| Summary | Full Text (HTML / PDF) |
letter
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ken J. Ishii et al.
Nature 451, 725–729
(7 February 2008); doi:10.1038/nature06537
| Summary | Full Text (HTML / PDF) |
review
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
Anthony G. Letai
Nature Reviews Cancer 8, 121–132
(February 2008); doi:10.1038/nrc2297
| Summary | Full Text (HTML / PDF) |
review
Lipid signalling in disease
Matthias P. Wymann & Roger Schneiter
Nature Reviews Molecular Cell Biology 9, 162–176
(February 2008); doi:10.1038/nrm2335
| Summary | Full Text (HTML / PDF) |
brief communication
Site selectivity of platinum anticancer therapeutics
Bin Wu, Peter Dröge & Curt A Davey
Nature Chemical Biology 4, 110–112
(February 2008); doi:10.1038/nchembio.2007.58
| Summary | Full Text (HTML / PDF) |
January
letter
G12–G13–LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Angela Wirth et al.
Nature Medicine 14, 64–68
(January 2008); doi:10.1038/nm1666
| Summary | Full Text (HTML / PDF) |
news and views
Salt abuse: the path to hypertension
Wilhelm Schoner
Nature Medicine 14, 16–17
(January 2008); doi:10.1038/nm0108-16
| Summary | Full Text (HTML / PDF) |
letter
A quantitative analysis of kinase inhibitor selectivity
Mazen W Karaman et al.
Nature Biotechnology 26, 127–132
(January 2008); doi:10.1038/nbt1358
| Summary | Full Text (HTML / PDF) |
perspective
Protein therapeutics: a summary and pharmacological classification
Benjamin Leader, Quentin J. Baca & David E. Golan
Nature Reviews Drug Discovery 7, 21–39
(January 2008); doi:10.1038/nrd2399
| Summary | Full Text (HTML / PDF) |
letter
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
Maksim V. Plikus et al.
Nature 451, 340–344
(17 January 2008); doi:10.1038/nature06457
| Summary | Full Text (HTML / PDF) |
letter
Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345–349
(17 January 2008); doi:10.1038/nature06489
| Summary | Full Text (HTML / PDF) |
article
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
Thirumalai R Ramalingam et al.
Nature Immunology 9, 25–33
(January 2008); doi:10.1038/ni1544
| Summary | Full Text (HTML / PDF) |
review
The expectant brain: adapting for motherhood
Paula J. Brunton & John A. Russell
Nature Reviews Neuroscience 9, 11–25
(January 2008); doi:10.1038/nrn2280
| Summary | Full Text (HTML / PDF) |
review
Regulation of iron acquisition and storage: consequences for iron-linked disorders
Ivana De Domenico, Diane McVey Ward & Jerry Kaplan
Nature Reviews Molecular Cell Biology 9, 72–81
(January 2008); doi:10.1038/nrm2295
| Summary | Full Text (HTML / PDF) |
article
Modification of kidney barrier function by the urokinase receptor
Changli Wei et al.
Nature Medicine 14, 55–63
(January 2008); doi:10.1038/nm1696
| Summary | Full Text (HTML / PDF) |
review
From inflammation to sickness and depression: when the immune system subjugates the brain
Robert Dantzer, Jason C. O'Connor, Gregory G. Freund, Rodney W. Johnson & Keith W. Kelley
Nature Reviews Neuroscience 9, 46–56
(January 2008); doi:10.1038/nrn2297
| Summary | Full Text (HTML / PDF) |
review
Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
Kishor M. Wasan, Dion R. Brocks, Stephen D. Lee, Kristina Sachs-Barrable & Sheila J. Thornton
Nature Reviews Drug Discovery 7, 84–99
(January 2008); doi:10.1038/nrd2353
| Summary | Full Text (HTML / PDF) |
|
