Research library: Clinical / Drug discovery
2009:
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December
article
Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries
Changiz Taghibiglou et al.
Nature Medicine 15, 1399–1406
(December 2009); doi:10.1038/nm.2064
| Summary | Full Text (HTML / PDF) |
news and views
Quelling cholesterol pathway fends off brain damage
Maria T Bengoechea-Alonso & Johan Ericsson
Nature Medicine 15, 1358–1359
(December 2009); doi:10.1038/nm1209-1358
| Full Text (HTML / PDF) |
letter
Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β
Toru Oga et al.
Nature Medicine 15, 1426–1430
(December 2009); doi:10.1038/nm.2066
| Summary | Full Text (HTML / PDF) |
news and views
Beyond TGF-β: a prostaglandin promotes fibrosis
Mitchell A Olman
Nature Medicine 15, 1360–1361
(December 2009); doi:10.1038/nm1209-1360
| Full Text (HTML / PDF) |
review
Generating specificity and diversity in the transcriptional response to hypoxia
Urban Lendahl, Kian Leong Lee, Henry Yang & Lorenz Poellinger
Nature Reviews Genetics 10, 821–832
(December 2009); doi:10.1038/nrg2665
| Summary | Full Text (HTML / PDF) |
article
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas
Leandro C Cerchietti et al.
Nature Medicine 15, 1369–1376
(December 2009); doi:10.1038/nm.2059
| Summary | Full Text (HTML / PDF) |
article
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Shu-ichi Okamoto et al.
Nature Medicine 15, 1407–1413
(December 2009); doi:10.1038/nm.2056
| Summary | Full Text (HTML / PDF) |
news and views
Memantine strikes the perfect balance
Albert R La Spada
Nature Medicine 15, 1355–1356
(December 2009); doi:10.1038/nm1209-1355
| Full Text (HTML / PDF) |
letter
Modulating hedgehog signaling can attenuate the severity of osteoarthritis
Alvin C Lin et al.
Nature Medicine 15, 1421–1425
(December 2009); doi:10.1038/nm.2055
| Summary | Full Text (HTML / PDF) |
review
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown, Sonia Lain, Chandra S. Verma, Alan R. Fersht & David P. Lane
Nature Reviews Cancer 9, 862–873
(December 2009); doi:10.1038/nrc2763
| Summary | Full Text (HTML / PDF) |
November
letter
Central control of fever and female body temperature by RANKL/RANK
Reiko Hanada et al.
Nature 462, 505–509
(26 November 2009); doi:10.1038/nature08596
| Full Text (HTML / PDF) |
letter
FLIP-mediated autophagy regulation in cell death control
Jong-Soo Lee et al.
Nature Cell Biology 11, 1355–1362
(1 November 2009) doi:10.1038/ncb1980
| Summary | Full Text (HTML / PDF) |
article
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
Masako Murai et al.
Nature Immunology 10, 1178–1184
(November 2009); doi:10.1038/ni.1791
| Summary | Full Text (HTML / PDF) |
news and views
The gut feeling of Treg cells: IL-10 is the silver lining during colitis
Derya Unutmaz & Bali Pulendran
Nature Immunology 10, 1141–1143
(November 2009); doi:10.1038/ni1109-1141
| Full Text (HTML / PDF) |
letter
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
Cristine Alves da Costa et al.
Nature Cell Biology 11, 1370–1375
(2009) doi:10.1038/ncb1981
| Summary | Full Text (HTML / PDF) |
review
Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases
Manolis Pasparakis
Nature Reviews Immunology 9, 778–788
(November 2009); doi:10.1038/nri2655
| Summary | Full Text (HTML / PDF) |
article
Notch3 signaling promotes the development of pulmonary arterial hypertension
Xiaodong Li et al.
Nature Medicine 15, 1289–1297
(November 2009); doi:10.1038/nm.2021
| Summary | Full Text (HTML / PDF) |
letter
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Zhiyong Cheng et al.
Nature Medicine 15, 1307–1311
(November 2009); doi:10.1038/nm.2049
| Summary | Full Text (HTML / PDF) |
review
Targeting protein kinases in central nervous system disorders
Laura K. Chico, Linda J. Van Eldik & D. Martin Watterson
Nature Reviews Drug Discovery 8, 892–909
(November 2009); doi:10.1038/nrd2999
| Summary | Full Text (HTML / PDF) |
article
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
Nature 462, 175–181
(12 November 2009); doi:10.1038/nature08506
| Full Text (HTML / PDF) |
news and views
Drug discovery: Predicting promiscuity
Andrew L. Hopkins
Nature 462, 167–168
(12 November 2009); doi:10.1038/462167a
| Full Text (HTML / PDF) |
article
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering et al.
Nature 462, 182–188
(12 November 2009); doi:10.1038/nature08543
| Full Text (HTML / PDF) |
news and views
Chemical biology: A Notch above other inhibitors
Paramjit S. Arora & Aseem Z. Ansari
Nature 462, 171–173
(12 November 2009); doi:10.1038/462171a
| Full Text (HTML / PDF) |
review
Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
James E. Cleaver, Ernest T. Lam & Ingrid Revet
Nature Reviews Genetics 10, 756–768
(November 2009); doi:10.1038/nrg2663
| Summary | Full Text (HTML / PDF) |
October
review
Complement regulators and inhibitory proteins
Peter F. Zipfel & Christine Skerka
Nature Reviews Immunology 9, 729–740
(October 2009); doi:10.1038/nri2620
| Summary | Full Text (HTML / PDF) |
article
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly
Masami Yamada et al.
Nature Medicine 15, 1202–1207
(October 2009); doi:10.1038/nm.2023
| Summary | Full Text (HTML / PDF) |
review
When mutants gain new powers: news from the mutant p53 field
Ran Brosh & Varda Rotter
Nature Reviews Cancer 9, 701–713
(October 2009); doi:10.1038/nrc2693
| Summary | Full Text (HTML / PDF) |
review
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
Bin-Bing S. Zhou et al.
Nature Reviews Drug Discovery 8, 806–823
(October 2009); doi:10.1038/nrd2137
| Summary | Full Text (HTML / PDF) |
letter
Sleep deprivation impairs cAMP signalling in the hippocampus
Christopher G. Vecsey et al.
Nature 461, 1122–1125
(22 October 2009); doi:10.1038/nature08488
| Full Text (HTML / PDF) |
review
The DNA-damage response in human biology and disease
Stephen P. Jackson & Jiri Bartek
Nature 461, 1071–1078
(22 October 2009); doi:10.1038/nature08467
| Full Text (HTML / PDF) |
article
Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
Torsten K Roepke et al.
Nature Medicine 15, 1186–1194
(October 2009); doi:10.1038/nm.2029
| Summary | Full Text (HTML / PDF) |
review
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
Kurt R. Brunden, John Q. Trojanowski & Virginia M.-Y. Lee
Nature Reviews Drug Discovery 8, 783–793
(October 2009); doi:10.1038/nrd2959
| Summary | Full Text (HTML / PDF) |
brief communication
Augmented photoswitching modulates immune signaling
Yixin Zhang, Frank Erdmann & Gunter Fischer
Nature Chemical Biology 5, 724–726
(October 2009); doi:10.1038/nchembio.214
| Summary | Full Text (HTML / PDF) |
article
Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death
Stefania Gonfloni et al.
Nature Medicine 15, 1179–1185
(October 2009); doi:10.1038/nm.2033
| Summary | Full Text (HTML / PDF) |
news and views
Preserving fertility during cancer treatment
Teresa K Woodruff
Nature Medicine 15, 1124–1125
(October 2009); doi:10.1038/nm1009-1124
| Full Text (HTML / PDF) |
article
Nicotine activates the chemosensory cation channel TRPA1
Karel Talavera et al.
Nature Neuroscience 12, 1293–1299
(October 2009); doi:10.1038/nn.2379
| Summary | Full Text (HTML / PDF) |
article
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
Marcin Kortylewski et al.
Nature Biotechnology 27, 925–932
(October 2009); doi:10.1038/nbt.1564
| Summary | Full Text (HTML / PDF) |
news and views
siRNA delivery not Toll-free
Michael P Gantier & Bryan R G Williams
Nature Biotechnology 27, 911–912
(October 2009); doi:10.1038/nbt1009-911
| Full Text (HTML / PDF) |
letter
Gene therapy for red–green colour blindness in adult primates
Katherine Mancuso et al.
Nature 461, 784–787
(08 October 2009); doi:10.1038/nature08401
| Full Text (HTML / PDF) |
news and views
Vision: Gene therapy in colour
Robert Shapley
Nature 461, 737–739
(08 October 2009); doi:10.1038/461737a
| Full Text (HTML / PDF) |
article
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
Jonathan W Day et al.
Nature Chemical Biology 5, 749–757
(October 2009); doi:10.1038/nchembio.209
| Summary | Full Text (HTML / PDF) |
brief communication
Augmented photoswitching modulates immune signaling
Yixin Zhang, Frank Erdmann & Gunter Fischer
Nature Chemical Biology 5, 724–726
(October 2009); doi:10.1038/nchembio.214
| Summary | Full Text (HTML / PDF) |
review
p53 and metabolism
Karen H. Vousden & Kevin M. Ryan
Nature Reviews Cancer 9, 691–700
(October 2009); doi:10.1038/nrc2715
| Summary | Full Text (HTML / PDF) |
review
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
John D. Imig & Bruce D. Hammock
Nature Reviews Drug Discovery 8, 794–805
(October 2009); doi:10.1038/nrd2875
| Summary | Full Text (HTML / PDF) |
September
article
Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
Mauricio F Farez et al.
Nature Immunology 10, 958–964
(September 2009); doi:10.1038/ni.1775
| Summary | Full Text (HTML / PDF) |
article
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
Juan M Ilarregui et al.
Nature Immunology 10, 981–991
(September 2009); doi:10.1038/ni.1772
| Summary | Full Text (HTML / PDF) |
article
Impaired Wnt—β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
Madeline A Lancaster et al.
Nature Medicine 15, 1046–1054
(September 2009); doi:10.1038/nm.2010
| Summary | Full Text (HTML / PDF) |
letter
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
Baohong Zhao et al.
Nature Medicine 15, 1066–1071
(September 2009); doi:10.1038/nm.2007
| Summary | Full Text (HTML / PDF) |
review
Biological determinants of endocrine resistance in breast cancer
Elizabeth A. Musgrove & Robert L. Sutherland
Nature Reviews Cancer 9, 631–643
(September 2009); doi:10.1038/nrc2713
| Summary | Full Text (HTML / PDF) |
letter
Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair
Viviana Cordeddu et al.
Nature Genetics 41, 1022–1026
(September 2009); doi:10.1038/ng.425
| Summary | Full Text (HTML / PDF) |
article
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
Luke S Tain et al.
Nature Neuroscience 12, 1129–1135
(September 2009); doi:10.1038/nn.2372
| Summary | Full Text (HTML / PDF) |
review
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Pasi A. Jänne, Nathanael Gray & Jeff Settleman
Nature Reviews Drug Discovery 8, 709–723
(September 2009); doi:10.1038/nrd2871
| Summary | Full Text (HTML / PDF) |
letter
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Tohru Minamino et al.
Nature Medicine 15, 1082–1087
(September 2009); doi:10.1038/nm.2014
| Summary | Full Text (HTML / PDF) |
news and views
Connecting obesity, aging and diabetes
Rexford S. Ahima
Nature Medicine 15, 996–997
(September 2009); doi:10.1038/nm0909-996
| Full Text (HTML / PDF) |
perspective
Environment-mediated drug resistance: a major contributor to minimal residual disease
Mark B. Meads, Robert A. Gatenby & William S. Dalton
Nature Reviews Cancer 9, 665–674
(September 2009); doi:10.1038/nrc2714
| Summary | Full Text (HTML / PDF) |
article
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
Justin P Dassie et al.
Nature Biotechnology 27, 839–846
(September 2009); doi:10.1038/nbt.1560
| Summary | Full Text (HTML / PDF) |
news and views
Silencing prostate cancer
Ivanka Toudjarska & Antonin de Fougerolles
Nature Biotechnology 27, 821–823
(September 2009); doi:10.1038/nbt0909-821
| Full Text (HTML / PDF) |
review
Protein methyltransferases as a target class for drug discovery
Robert A. Copeland, Michael E. Solomon & Victoria M. Richon
Nature Reviews Drug Discovery 8, 724–732
(September 2009); doi:10.1038/nrd2974
| Summary | Full Text (HTML / PDF) |
letter
Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
Sunny Y Wong et al.
Nature Medicine 15, 1055–1061
(September 2009); doi:10.1038/nm.2011
| Summary | Full Text (HTML / PDF) |
letter
Dual and opposing roles of primary cilia in medulloblastoma development
Young-Goo Han et al.
Nature Medicine 15, 1062–1065
(September 2009); doi:10.1038/nm.2020
| Summary | Full Text (HTML / PDF) |
news and views
Two sides to cilia in cancer
Rune Toftgård
Nature Medicine 15, 994–996
(September 2009); doi:10.1038/nm0909-994
| Full Text (HTML / PDF) |
perspective
Cancer stem cells: mirage or reality?
Piyush B Gupta, Christine L Chaffer & Robert A Weinberg
Nature Medicine 15, 1010–1012
(September 2009); doi:10.1038/nm0909-1010
| Summary | Full Text (HTML / PDF) |
review
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Antoine Taly, Pierre-Jean Corringer, Denis Guedin, Pierre Lestage & Jean-Pierre Changeux
Nature Reviews Drug Discovery 8, 733–750
(September 2009); doi:10.1038/nrd2927
| Summary | Full Text (HTML / PDF) |
letter
Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
Stephanie L Bielas et al.
Nature Genetics 41, 1032–1036
(September 2009); doi:10.1038/ng.423
| Summary | Full Text (HTML / PDF) |
review
Target profiling of small molecules by chemical proteomics
Uwe Rix & Giulio Superti-Furga
Nature Chemical Biology 5, 616–624
(September 2009); doi:10.1038/nchembio.216
| Summary | Full Text (HTML / PDF) |
August
review
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Jeffrey A. Engelman
Nature Reviews Cancer 9, 550–562
(August 2009); doi:10.1038/nrc2664
| Summary | Full Text (HTML / PDF) |
review
The glutamate homeostasis hypothesis of addiction
Peter W. Kalivas
Nature Reviews Neuroscience 10, 561–572
(August 2009); doi:10.1038/nrn2515
| Summary | Full Text (HTML / PDF) |
review
Therapeutic manipulation of immune tolerance in allergic disease
Mübeccel Akdis & Cezmi A. Akdis
Nature Reviews Drug Discovery 8, 645–660
(August 2009); doi:10.1038/nrd2653
| Summary | Full Text (HTML / PDF) |
article
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Sang-Moon Yun et al.
Nature Structural & Molecular Biology 16,
doi:10.1038/nsmb.1628
| Summary | Full Text (HTML / PDF) |
letter
Characterization of two classes of small molecule inhibitors of Arp2/3 complex
B. J. Nolen et al.
Nature 460, 1031–1034
(20 August 2009); doi:10.1038/nature08231
| Full Text (HTML / PDF) |
technical report
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis
Manav Korpal et al.
Nature Medicine 15, 960–966
(August 2009); doi:10.1038/nm.1943
| Summary | Full Text (HTML / PDF) |
letter
Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury
Takashi Shichita et al.
Nature Medicine 15, 946–950
(August 2009); doi:10.1038/nm.1999
| Summary | Full Text (HTML / PDF) |
news and views
T time in the brain
Eng H Lo
Nature Medicine 15, 844–846
(August 2009); doi:10.1038/nm0809-844
| Full Text (HTML / PDF) |
perspective
Cellular assays as portals to seven-transmembrane receptor-based drug discovery
Terry P. Kenakin
Nature Reviews Drug Discovery 8, 617–626
(August 2009); doi:10.1038/nrd2838
| Summary | Full Text (HTML / PDF) |
review
CYP2D6 and tamoxifen: DNA matters in breast cancer
Janelle M. Hoskins, Lisa A. Carey & Howard L. McLeod
Nature Reviews Cancer 9, 576–586
(August 2009); doi:10.1038/nrc2683
| Summary | Full Text (HTML / PDF) |
review
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu, Hailing Cheng, Thomas M. Roberts & Jean J. Zhao
Nature Reviews Drug Discovery 8, 627–644
(August 2009); doi:10.1038/nrd2926
| Summary | Full Text (HTML / PDF) |
July
letter
Presenilins are essential for regulating neurotransmitter release
Chen Zhang et al.
Nature 460, 632–636
(30 July 2009); doi:10.1038/nature08177
| Full Text (HTML / PDF) |
article
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
Gerardo A Morfini et al.
Nature Neuroscience 12, 864–871
(July 2009); doi:10.1038/nn.2346
| Summary | Full Text (HTML / PDF) |
brief communication
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li et al.
Nature Neuroscience 12, 826–828
(July 2009); doi:10.1038/nn.2349
| Summary | Full Text (HTML / PDF) |
research
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma
Terri A Addona et al.
Nature Biotechnology 27, 633–641
(July 2009); doi:10.1038/nbt.1546
| Summary | Full Text (HTML / PDF) |
news and views
Biomarker validation by targeted mass spectrometry
Martin McIntosh & Matthew Fitzgibbon
Nature Biotechnology 27, 622–623
(July 2009); doi:10.1038/nbt0709-622
| Full Text (HTML / PDF) |
review
Cell cycle kinases as therapeutic targets for cancer
Silvia Lapenna & Antonio Giordano
Nature Reviews Drug Discovery 8, 547–566
(July 2009); doi:10.1038/nrd2907
| Summary | Full Text (HTML / PDF) |
article
Quantifying biogenic bias in screening libraries
Jérôme Hert, John J Irwin, Christian Laggner, Michael J Keiser & Brian K Shoichet
Nature Chemical Biology 5, 479–483
(July 2009); doi:10.1038/nchembio.180
| Summary | Full Text (HTML / PDF) |
review
New insights into the regulation of T cells by γc family cytokines
Yrina Rochman, Rosanne Spolski & Warren J. Leonard
Nature Reviews Immunology 9, 480–490
(July 2009); doi:10.1038/nri2580
| Summary | Full Text (HTML / PDF) |
letter
Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
Yorihiro Nishimura et al.
Nature Medicine 15, 794–797
(July 2009); doi:10.1038/nm.1961
| Summary | Full Text (HTML / PDF) |
letter
Scavenger receptor B2 is a cellular receptor for enterovirus 71
Seiya Yamayoshi et al.
Nature Medicine 15, 798–801
(July 2009); doi:10.1038/nm.1992
| Summary | Full Text (HTML / PDF) |
news and views
Receptors identified for hand, foot and mouth virus
Kunal P. Patel & Jeffrey M. Bergelson
Nature Medicine 15, 728–729
(July 2009); doi:10.1038/nm0709-728
| Full Text (HTML / PDF) |
review
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
José Baselga & Sandra M. Swain
Nature Reviews Cancer 9, 463–475
(July 2009); doi:10.1038/nrc2656
| Summary | Full Text (HTML / PDF) |
article
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Philip L De Jager et al.
Nature Genetics 41, 776–782
(July 2009); doi:10.1038/ng.401
| Summary | Full Text (HTML / PDF) |
review
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
Yan Feng, Timothy J. Mitchison, Andreas Bender, Daniel W. Young & John A. Tallarico
Nature Reviews Drug Discovery 8, 567–578
(July 2009); doi:10.1038/nrd2876
| Summary | Full Text (HTML / PDF) |
article
Inhibitor hijacking of Akt activation
Tatsuya Okuzumi et al.
Nature Chemical Biology 5, 484–493
(July 2009); doi:10.1038/nchembio.183
| Summary | Full Text (HTML / PDF) |
news and views
Inhibitors paradoxically prime kinases
Stephen V Frye & Gary L Johnson
Nature Chemical Biology 5, 448–449
(July 2009); doi:10.1038/nchembio.f.11
| Full Text (HTML / PDF) |
article
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
Yi Tang et al.
Nature Medicine 15, 757–765
(July 2009); doi:10.1038/nm.1979
| Summary | Full Text (HTML / PDF) |
news and views
Coupling bone degradation to formation
Jameel Iqbal, Li Sun & Mone Zaidi
Nature Medicine 15, 729–731
(July 2009); doi:10.1038/nm0709-729
| Full Text (HTML / PDF) |
article
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
Tony Muchamuel et al.
Nature Medicine 15, 781–787
(July 2009); doi:10.1038/nm.1978
| Summary | Full Text (HTML / PDF) |
article
Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug
Jennifer A MacDiarmid et al.
Nature Biotechnology 27, 643–651
(July 2009); doi:10.1038/nbt.1547
| Summary | Full Text (HTML / PDF) |
news and views
Minicells overcome tumor drug-resistance
Emmanouil D Karagiannis & Daniel G Anderson
Nature Biotechnology 27, 620–621
(July 2009); doi:10.1038/nbt0709-620
| Full Text (HTML / PDF) |
article
CCR3 is a target for age-related macular degeneration diagnosis and therapy
Atsunobu Takeda et al.
Nature 460, 225–230
(09 July 2009); doi:10.1038/nature08151
| Full Text (HTML / PDF) |
news and views
Vision: New light on allergy receptor
Maria Grant
Nature 460, 182–183
(09 July 2009); doi:10.1038/460182a
| Full Text (HTML / PDF) |
review
Cracking the BAFF code
Fabienne Mackay & Pascal Schneider
Nature Reviews Immunology 9, 491–502
(July 2009); doi:10.1038/nri2572
| Summary | Full Text (HTML / PDF) |
article
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
Hayriye V Erkizan et al.
Nature Medicine 15, 750–756
(July 2009); doi:10.1038/nm.1983
| Summary | Full Text (HTML / PDF) |
review
Genetic prognostic and predictive markers in colorectal cancer
Axel Walther et al.
Nature Reviews Cancer 9, 489–499
(July 2009); doi:10.1038/nrc2645
| Summary | Full Text (HTML / PDF) |
letter
Lin28 promotes transformation and is associated with advanced human malignancies
Srinivas R Viswanathan et al.
Nature Genetics 41, 843–848
(July 2009); doi:10.1038/ng.392
| Summary | Full Text (HTML / PDF) |
news and views
Tumors line up for a letdown
Joshua T Mendell
Nature Genetics 41, 768–769
(July 2009); doi:10.1038/ng0709-768
| Full Text (HTML / PDF) |
review
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Dunyaporn Trachootham, Jerome Alexandre & Peng Huang
Nature Reviews Drug Discovery 8, 579–591
(July 2009); doi:10.1038/nrd2803
| Summary | Full Text (HTML / PDF) |
article
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Christian Heinis, Trevor Rutherford, Stephan Freund & Greg Winter
Nature Chemical Biology 5, 502–507
(July 2009); doi:10.1038/nchembio.184
| Summary | Full Text (HTML / PDF) |
news and views
Encoding chemistry
Dario Neri & André W Brändli
Nature Chemical Biology 5, 452–453
(July 2009); doi:10.1038/nchembio0709-452
| Full Text (HTML / PDF) |
review
Signalling through C-type lectin receptors: shaping immune responses
Teunis B. H. Geijtenbeek & Sonja I. Gringhuis
Nature Reviews Immunology 9, 465–479
(July 2009); doi:10.1038/nri2569
| Summary | Full Text (HTML / PDF) |
article
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Courtney M Karner et al.
Nature Genetics 41, 793–799
(July 2009); doi:10.1038/ng.400
| Summary | Full Text (HTML / PDF) |
letter
REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
Peter K Gregersen et al.
Nature Genetics 41, 820–823
(July 2009); doi:10.1038/ng.395
| Summary | Full Text (HTML / PDF) |
review
The genetic contribution to non-syndromic human obesity
Andrew J. Walley, Julian E. Asher & Philippe Froguel
Nature Reviews Genetics 10, 431–442
(July 2009); doi:10.1038/nrg2594
| Summary | Full Text (HTML / PDF) |
June
article
Inhibition of osteoblastic bone formation by nuclear factor-κB
Jia Chang et al.
Nature Medicine 15, 682–689
(June 2009); doi:10.1038/nm.1954
| Summary | Full Text (HTML / PDF) |
letter
Narcolepsy is strongly associated with the T-cell receptor alpha locus
Joachim Hallmayer et al.
Nature Genetics 41, 708–711
(June 2009); doi:10.1038/ng.372
| Summary | Full Text (HTML / PDF) |
news and views
Narcolepsy and the T-cell receptor
Timothy J Vyse
Nature Genetics 41, 640–641
(June 2009); doi:10.1038/ng0609-640
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Unleashing the therapeutic potential of NOD-like receptors
Kaoru Geddes, João G. Magalhães & Stephen E. Girardin
Nature Reviews Drug Discovery 8, 465–479
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A protective function for interleukin 17A in T cell–mediated intestinal inflammation
William O'Connor Jr et al.
Nature Immunology 10, 603–609
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IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation
Amit Awasthi & Vijay K Kuchroo
Nature Immunology 10, 568–570
(June 2009); doi:10.1038/ni0609-568
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Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome
Thu A Chau et al.
Nature Medicine 15, 641–648
(June 2009); doi:10.1038/nm.1965
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A shear gradient–dependent platelet aggregation mechanism drives thrombus formation
Warwick S Nesbitt et al.
Nature Medicine 15, 665–673
(June 2009); doi:10.1038/nm.1955
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In the shadow of the thrombus
Lawrence Brass
Nature Medicine 15, 607–608
(June 2009); doi:10.1038/nm0609-607
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Targeting innate immunity protein kinase signalling in inflammation
Matthias Gaestel, Alexey Kotlyarov & Michael Kracht
Nature Reviews Drug Discovery 8, 480–499
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The biology of ovarian cancer: new opportunities for translation
Robert C. Bast, Bryan Hennessy & Gordon B. Mills
Nature Reviews Cancer 9, 415–428
(June 2009); doi:10.1038/nrc2644
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Regulation of innate immune responses in the brain
Serge Rivest
Nature Reviews Immunology 9, 429–439
(June 2009); doi:10.1038/nri2565
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May
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Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
Marc Pellegrini et al.
Nature Medicine 15, 528–536
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Radiation-induced bystander signalling in cancer therapy
Kevin M. Prise & Joe M. O'Sullivan
Nature Reviews Cancer 9, 351–360
(May 2009); doi:10.1038/nrc2603
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Assessing the potential of glucokinase activators in diabetes therapy
Franz M. Matschinsky
Nature Reviews Drug Discovery 8, 399–416
(May 2009); doi:10.1038/nrd2850
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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Sabrina L. Spencer, Suzanne Gaudet, John G. Albeck, John M. Burke & Peter K. Sorger
Nature 459, 428–432
(21 May 2009); doi:10.1038/nature08012
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Systems biology: When it is time to die
Philippe Bastiaens
Nature 459, 334–335
(21 May 2009); doi:10.1038/459334a
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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
Agnes Machnik et al.
Nature Medicine 15, 545–552
(May 2009); doi:10.1038/nm.1960
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Blood pressure control: salt gets under your skin
Paul J Marvar, Frank J Gordon & David G Harrison
Nature Medicine 15, 487–488
(May 2009); doi:10.1038/nm0509-487
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BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort et al.
Nature Genetics 41, 544–552
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Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma
Sangeeta Goswami et al.
Nature Immunology 10, 496–503
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Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
Bo Ahrén
Nature Reviews Drug Discovery 8, 369–385
(May 2009); doi:10.1038/nrd2782
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The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death
Takahiro Miyawaki et al.
Nature Neuroscience 12, 618–626
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Therapeutic targets to reduce cardiovascular disease in type 2 diabetes
Cyrus DeSouza & Vivian Fonseca
Nature Reviews Drug Discovery 8, 361–367
(May 2009); doi:10.1038/nrd2872
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Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Myriam Aouadi et al.
Nature 458, 1180–1184
(30 April 2009); doi:10.1038/nature07774
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A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
Eiichiro Noguchi, Yoichiro Homma, Xiaoyan Kang, Mihai G Netea & Xiaojing Ma
Nature Immunology 10, 471–479
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Crohn's disease-associated Nod2 mutants reduce IL10 transcription
Dana J Philpott & Stephen E Girardin
Nature Immunology 10, 455–457
(May 2009); doi:10.1038/ni0509-455
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Tumour necrosis factor and cancer
Frances Balkwill
Nature Reviews Cancer 9, 361–371
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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Guojun Bu
Nature Reviews Neuroscience 10, 333–344
(May 2009); doi:10.1038/nrn2620
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Targeting the CNS to treat type 2 diabetes
Darleen A. Sandoval, Silvana Obici & Randy J. Seeley
Nature Reviews Drug Discovery 8, 386–398
(May 2009); doi:10.1038/nrd2874
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Molecular docking and ligand specificity in fragment-based inhibitor discovery
Yu Chen & Brian K Shoichet
Nature Chemical Biology 5, 358–364
(May 2009); doi:10.1038/nchembio.155
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Fragment-based drug discovery takes a virtual turn
Maurizio Pellecchia
Nature Chemical Biology 5, 274–275
(May 2009); doi:10.1038/nchembio0509-274
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April
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Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis
Nikolaus B Binder et al.
Nature Medicine 15, 417–424
(April 2009); doi:10.1038/nm.1945
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Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
John D. Baxter & Paul Webb
Nature Reviews Drug Discovery 8, 308–320
(April 2009); doi:10.1038/nrd2830
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The role of TNF superfamily members in T-cell function and diseases
Michael Croft
Nature Reviews Immunology 9, 271–285
(April 2009); doi:10.1038/nri2526
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Learning therapeutic lessons from metastasis suppressor proteins
Steven Christopher Smith & Dan Theodorescu
Nature Reviews Cancer 9, 253–264
(April 2009); doi:10.1038/nrc2594
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Capturing adenylyl cyclases as potential drug targets
Sandra Pierre, Thomas Eschenhagen, Gerd Geisslinger & Klaus Scholich
Nature Reviews Drug Discovery 8, 321–335
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A network view of disease and compound screening
Eric E. Schadt, Stephen H. Friend & David A. Shaywitz
Nature Reviews Drug Discovery 8, 286–295
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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
Nature 458, 732–736
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Drug Discovery: Fresh target for cancer therapy
Raymond J. Deshaies
Nature 458, 709–710
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Selectivity and therapeutic inhibition of kinases: to be or not to be?
Kamran Ghoreschi, Arian Laurence & John J O'Shea
Nature Immunology 10, 356–360
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Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
Andrés Hidalgo et al.
Nature Medicine 15, 384–391
(April 2009); doi:10.1038/nm.1939
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Neutrophil sandwiches injure the microcirculation
Mark R Looney & Michael A Matthay
Nature Medicine 15, 364–366
(April 2009); doi:10.1038/nm0409-364
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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
Hamida Hammad et al.
Nature Medicine 15, 410–416
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Dust mites' dirty dealings in the lung
Clare M Lloyd
Nature Medicine 15, 366–367
(April 2009); doi:10.1038/nm0409-366
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Lack of the bone morphogenetic protein BMP6 induces massive iron overload
Delphine Meynard et al.
Nature Genetics 41, 478–481
(April 2009); doi:10.1038/ng.320
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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Billy Andriopoulos Jr et al.
Nature Genetics 41, 482–487
(April 2009); doi:10.1038/ng.335
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BMP6 orchestrates iron metabolism
Clara Camaschella
Nature Methods 41, 386–388
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Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
David Marsolais & Hugh Rosen
Nature Reviews Drug Discovery 8, 297–307
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March
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Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
Masaru Ishii et al.
Nature 458, 524–528
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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
Alan H Nagahara et al.
Nature Medicine 15, 331–337
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Beyond chemotherapy: targeted therapies in ovarian cancer
Timothy A. Yap, Craig P. Carden & Stan B. Kaye
Nature Reviews Cancer 9, 167–181
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Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle
Andrew M Bellinger et al.
Nature Medicine 15, 325–330
(March 2009); doi:10.1038/nm.1916
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NO may prompt calcium leakage in dystrophic muscle
James G Tidball & S Armando Villalta
Nature Medicine 15, 243–244
(March 2009); doi:10.1038/nm0309-243
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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
Alan H Nagahara et al.
Nature Medicine 15, 331–337
(March 2009); doi:10.1038/nm.1912
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TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction
A Kemal Topaloglu et al.
Nature Genetics 41, 354–358
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The neurokinin B pathway in human reproduction
Ana Claudia Latronico
Nature Genetics 41, 269–270
(March 2009); doi:10.1038/ng0309-269
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Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations
John F. Bateman, Raymond P. Boot-Handford & Shireen R. Lamandé
Nature Reviews Genetics 10, 173–183
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Molecular targets for cancer chemoprevention
William N. William, Jr, John V. Heymach, Edward S. Kim & Scott M. Lippman
Nature Reviews Drug Discovery 8, 213–225
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A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
Nikolay L Malinin et al.
Nature Medicine 15, 313–318
(March 2009); doi:10.1038/nm.1917
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Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells
Markus Moser et al.
Nature Medicine 15, 300–305
(March 2009); doi:10.1038/nm.1921
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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
Lena Svensson et al.
Nature Medicine 15, 306–312
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When integrins fail to integrate
Andrés Hidalgo & Paul S Frenette
Nature Medicine 15, 249–250
(March 2009); doi:10.1038/nm0309-249
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Mapping complex disease traits with global gene expression
William Cookson, Liming Liang, Gonçalo Abecasis, Miriam Moffatt & Mark Lathrop
Nature Reviews Genetics 10, 184–194
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Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Marie Carlén et al.
Nature Neuroscience 12, 259–267
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Notch keeps ependymal cells in line
Chunmei Zhao, Hoonkyo Suh & Fred H Gage
Nature Neuroscience 12, 243–245
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The FGF family: biology, pathophysiology and therapy
Andrew Beenken & Moosa Mohammadi
Nature Reviews Drug Discovery 8, 235–253
(March 2009); doi:10.1038/nrd2792
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brief communication
A small molecule that binds Hedgehog and blocks its signaling in human cells
Benjamin Z Stanton et al.
Nature Chemical Biology 5, 154–156
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α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
Aaron D Gitler et al.
Nature Genetics 41, 308–315
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Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity
Esti Yeger-Lotem et al.
Nature Genetics 41, 316–323
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February
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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
Juha Laurén et al.
Nature 457, 1128–1132
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Alzheimer's disease: A prion protein connection
Moustapha Cisse & Lennart Mucke
Nature 457, 1090–1091
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De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
Volodymyr Gerzanich et al.
Nature Medicine 15, 185–191
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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
Peter Fraisl, Julián Aragonés & Peter Carmeliet
Nature Reviews Drug Discovery 8, 139–152
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Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
Arthur Liesz et al.
Nature Medicine 15, 192–199
(February 2009); doi:10.1038/nm.1927
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Regulatory T cells protect the brain after stroke
Anna M Planas & Angel Chamorro
Nature Medicine 15, 138–139
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Mechanisms of drug combinations: interaction and network perspectives
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Nature Reviews Drug Discovery 8, 111–128
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Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway
Benjamin Kleaveland et al.
Nature Medicine 15, 169–176
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The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
Kevin J Whitehead et al.
Nature Medicine 15, 177–184
(February 2009); doi:10.1038/nm.1911
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Torturing a blood vessel
Cam Patterson
Nature Medicine 15, 137–138
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Chloride channels as drug targets
Alan S. Verkman & Luis J. V. Galietta
Nature Reviews Drug Discovery 8, 153–171
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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen et al.
Nature Chemical Biology 5, 100–107
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Novel Wnt antagonists target porcupine and Axin
Jing-Ruey J Yeh & Randall T Peterson
Nature Chemical Biology 5, 74–75
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Plasma lipoproteins: genetic influences and clinical implications
Robert A. Hegele
Nature Reviews Genetics 10, 109–121
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January
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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
Aurelien Trompette et al.
Nature 457, 585–588
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Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Catherine D. Van Raamsdonk et al.
Nature 457, 599–602
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Mechanotransduction in vascular physiology and atherogenesis
Cornelia Hahn & Martin A. Schwartz
Nature Reviews Molecular Cell Biology 10, 53–62
(January 2009); doi:10.1038/nrm2596
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Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production
Krisztián Németh et al.
Nature Medicine 15, 42–49
(January 2009); doi:10.1038/nm.1905
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news and views
Mesenchymal stem cells combat sepsis
Alan Tyndall & Vito Pistoia
Nature Medicine 15, 18–20
(January 2009); doi:10.1038/nm0109-18
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The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Michael Haberland, Rusty L. Montgomery & Eric N. Olson
Nature Reviews Genetics 10, 32–42
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Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa
Claudio Punzo, Karl Kornacker & Constance L Cepko
Nature Neuroscience 12, 44–52
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Retinitis pigmentosa: cone photoreceptors starving to death
Paola Bovolenta & Elsa Cisneros
Nature Neuroscience 12, 5–6
(January 2009); doi:10.1038/nn0109-5
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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
P. Jeffrey Conn, Arthur Christopoulos & Craig W. Lindsley
Nature Reviews Drug Discovery 8, 41–54
(January 2009); doi:10.1038/nrd2760
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The promises and pitfalls of RNA-interference-based therapeutics
Daniela Castanotto & John J. Rossi
Nature 457, 426–433
(22 January 2009); doi:10.1038/nature07758
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Mechanotransduction gone awry
Diana E. Jaalouk & Jan Lammerding
Nature Reviews Molecular Cell Biology 10, 63–73
(January 2009); doi:10.1038/nrm2597
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Is NF-κB a good target for cancer therapy? Hopes and pitfalls
Véronique Baud & Michael Karin
Nature Reviews Drug Discovery 8, 33–40
(January 2009); doi:10.1038/nrd2781
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Induced pluripotent stem cells from a spinal muscular atrophy patient
Allison D. Ebert et al.
Nature 457, 277–280
(15 January 2009); doi:10.1038/nature07677
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Stem cells: Tailor-made diseased neurons
Michael Sendtner
Nature 457, 269–270
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γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J Real et al.
Nature Medicine 15, 50–58
(January 2009); doi:10.1038/nm.1900
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γ-secretase inhibitors: Notch so bad
Gerard C Grosveld
Nature Medicine 15, 20–21
(January 2009); doi:10.1038/nm0109-20
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Detecting shared pathogenesis from the shared genetics of immune-related diseases
Alexandra Zhernakova, Cleo C. van Diemen & Cisca Wijmenga
Nature Reviews Genetics 10, 43–55
(January 2009); doi:10.1038/nrg2489
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perspective
Chemokine receptor antagonists: overcoming developmental hurdles
Richard Horuk
Nature Reviews Drug Discovery 8, 23–33
(January 2009); doi:10.1038/nrd2734
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Targeting cancer with small molecule kinase inhibitors
Jianming Zhang, Priscilla L. Yang & Nathanael S. Gray
Nature Reviews Cancer 9, 28–39
(January 2009); doi:10.1038/nrc2559
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Transient receptor potential channels: targeting pain at the source
Ardem Patapoutian, Simon Tate & Clifford J. Woolf
Nature Reviews Drug Discovery 8, 55–68
(January 2009); doi:10.1038/nrd2757
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