Research library: Clinical / Drug discovery
2010:
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August
article
Type IIA topoisomerase inhibition by a new class of antibacterial agents
Benjamin D. Bax et al.
Nature 466, 935–940
(19 August 2010); doi:10.1038/nature09197
| Full Text (HTML / PDF) |
letter
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Matthew P. R. Berry et al.
Nature 466, 973–977
(19 August 2010); doi:10.1038/nature09247
| Full Text (HTML / PDF) |
July
review
SGLT2 inhibition — a novel strategy for diabetes treatment
Edward C. Chao & Robert R. Henry
Nature Reviews Drug Discovery 9, 551–559
(July 2010); doi:10.1038/nrd3180
| Summary | Full Text (HTML / PDF) |
review
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
Harald Hampel et al.
Nature Reviews Drug Discovery 9, 560–574
(July 2010); doi:10.1038/nrd3115
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review
Structure-based discovery of antibacterial drugs
Katie J. Simmons, Ian Chopra & Colin W. G. Fishwick
Nature Reviews Microbiology 8, 501–510
(July 2010); doi:10.1038/nrmicro2349
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article
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans
Andrew R Burns et al.
Nature Chemical Biology 6, 549–557
(July 2010); doi:10.1038/nchembio.380
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article
Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
Frédéric Chibon et al.
Nature Medicine 16, 781–787
(July 2010); doi:10.1038/nm.2174
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perspective
Integrating molecular diagnostics into anticancer drug discovery
István Peták, Richárd Schwab, László Orfi, László Kopper & György Kéri
Nature Reviews Drug Discovery 9, 523–535
(July 2010); doi:10.1038/nrd3135
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review
Aptamers as therapeutics
Anthony D. Keefe, Supriya Pai & Andrew Ellington
Nature Reviews Drug Discovery 9, 537–550
(July 2010); doi:10.1038/nrd3141
| Summary | Full Text (HTML / PDF) |
June
article
Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis
Adam B Castoreno et al.
Nature Chemical Biology 6, 457–463
(June 2010); doi:10.1038/nchembio.363
| Summary | Full Text (HTML / PDF) |
news and views
High-content screens: Giving Rho(d) directions
Markus K Muellner & Sebastian M B Nijman
Nature Chemical Biology 6, 397–398
(June 2010); doi:10.1038/nchembio.373
| Full Text (HTML / PDF) |
May
review
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera & Benoit Bilanges
Nature Reviews Molecular Cell Biology 11, 329–341
(May 2010); doi:10.1038/nrm2882
| Summary | Full Text (HTML / PDF) |
February
review
Anti-virulence strategies to combat bacteria-mediated disease
David A. Rasko & Vanessa Sperandio
Nature Reviews Drug Discovery 9, 117–128
(February 2010); doi:10.1038/nrd3013
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January
brief communication
In vivo selection of tumor-targeting RNA motifs
Jing Mi et al.
Nature Chemical Biology 6, 22–24
(January 2010); doi:10.1038/nchembio.277
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review
Macrophage death and defective inflammation resolution in atherosclerosis
Ira Tabas
Nature Reviews Immunology 10, 36–46
(January 2010); doi:10.1038/nri2675
| Summary | Full Text (HTML / PDF) |
review
From pathogenesis to treatment of chronic lymphocytic leukaemia
Thorsten Zenz, Daniel Mertens, Ralf Küppers, Hartmut Döhner & Stephan Stilgenbauer
Nature Reviews Cancer 10, 37–50
(January 2010); doi:10.1038/nrc2764
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letter
Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies
Selvaraju Veeriah et al.
Nature Genetics 42, 77–82
(January 2010); doi:10.1038/ng.491
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review
Kinase mutations in human disease: interpreting genotype–phenotype relationships
Piya Lahiry, Ali Torkamani, Nicholas J. Schork & Robert A. Hegele
Nature Reviews Genetics 11, 60–74
(January 2010); doi:10.1038/nrg2707
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review
The nuts and bolts of AGC protein kinases
Laura R. Pearce, David Komander & Dario R. Alessi
Nature Reviews Molecular Cell Biology 11, 9–22
(January 2010); doi:10.1038/nrm2822
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review
Integrins in cancer: biological implications and therapeutic opportunities
Jay S. Desgrosellier & David A. Cheresh
Nature Reviews Cancer 10, 9–22
(January 2010); doi:10.1038/nrc2748
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brief communication
A restricted spectrum of NRAS mutations causes Noonan syndrome
Ion C Cirstea et al.
Nature Genetics 42, 27–29
(January 2010); doi:10.1038/ng.497
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letter
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
Wenjun Zhou et al.
Nature 462, 1070–1074
(24 December 2009); doi:10.1038/nature08622
| Full Text (HTML / PDF) |
article
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
Darren M Hutt et al.
Nature Chemical Biology 6, 25–33
(January 2010); doi:10.1038/nchembio.275
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