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Research library: Development

2006: December | November | October | September | August | July | June | May | April | March | February | January

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article
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston
Nature 444, 1032–1037
(21 December 2006); doi:10.1038/nature05355
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letter
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J. Watts, Christopher Callahan, Ian Kasman, Mallika Singh, May Chien, Christine Tan, Jo-Anne S. Hongo, Fred de Sauvage, Greg Plowman and Minhong Yan
Nature 444, 1083–1087
(21 December 2006); doi:10.1038/nature05313
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article
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer, George A. Garinis, Anja Raams, Astrid S. Lalai, Andria Rasile Robinson, Esther Appeldoorn, Hanny Odijk, Roos Oostendorp, Anwaar Ahmad, Wibeke van Leeuwen, Arjan F. Theil, Wim Vermeulen, Gijsbertus T. J. van der Horst, Peter Meinecke, Wim J. Kleijer, Jan Vijg, Nicolaas G. J. Jaspers and Jan H. J. Hoeijmakers
Nature 444, 1038–1043
(21 December 2006); doi:10.1038/nature05456
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Early events in the thymus affect the balance of effector and regulatory T cells
Daniel J. Pennington, Bruno Silva-Santos, Tobias Silberzahn, Mónica Escórcio-Correia, Martin J. Woodward, Scott J. Roberts, Adrian L. Smith, P. Julian Dyson and Adrian C. Hayday
Nature 444, 1073–1077
(21 December 2006); doi:10.1038/nature05368
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Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
Lucia Di Marcotullio, Elisabetta Ferretti, Azzura Greco, Enrico De Smaele, Agnese Po, Maria Anna Sico, Maurizio Alimandi, Giuseppe Giannini, Marella Maroder, Isabella Screpanti & Alberto Gulino
Nature Cell Biology 8, 1415–1423
(December 2006); doi:10.1038/ncb1510
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letter
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
Kojiro Sato, Ayako Suematsu, Tomoki Nakashima, Sayaka Takemoto-Kimura, Kazuhiro Aoki, Yasuyuki Morishita, Hiroshi Asahara, Keiichi Ohya, Akira Yamaguchi, Toshiyuki Takai, Tatsuhiko Kodama, Talal A Chatila, Haruhiko Bito & Hiroshi Takayanagi
Nature Medicine 12, 1410–1416
(December 2006); doi:10.1038/nm1515
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letter
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation
Seoung-Hoon Lee, Jaerang Rho, Daewon Jeong, Jai-Yoon Sul, Taesoo Kim, Nacksung Kim, Ju-Seob Kang, Takeshi Miyamoto, Toshio Suda, Sun-Kyeong Lee, Robert J Pignolo, Boguslawa Koczon-Jaremko, Joseph Lorenzo & Yongwon Choi
Nature Medicine 12, 1403–1409
(December 2006); doi:10.1038/nm1514
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review
How flies get their size: genetics meets physiology
Bruce A. Edgar
Nature Reviews Genetics 7, 907–916
(December 2006); doi:10.1038/nrg1989
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news and views
Of Fat flies and Hippos, or the magic of animal size
Fernando Casares, Carlos M Luque & Maria J Tavares
Nature Structural & Molecular Biology 13, 1051–1053
(December 2006); doi:10.1038/nsmb1206-1051
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letter
The cytohesin Steppke is essential for insulin signalling in Drosophila
Bernhard Fuss, Thomas Becker, Ingo Zinke and Michael Hoch
Nature 444, 945–948
(14 December 2006); doi:10.1038/nature05412
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A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
Jong In Yook, Xiao-Yan Li, Ichiro Ota, Casey Hu, Hyun Sil Kim, Nam Hee Kim, So Young Cha, Joo Kyung Ryu, Yoon Jung Choi, Jin Kim, Eric R. Fearon & Stephen J. Weiss
Nature Cell Biology 8, 1398–1406
(December 2006); doi:10.1038/ncb1508
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letter
Centriole assembly in Caenorhabditis elegans
Alastair M. Hosie, Megan E. Wilkins, Helena M. A. da Silva and Trevor G. Smart
Nature 444, 619–623
(30 November 2006); doi:10.1038/nature05318
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review
Adipocyte differentiation from the inside out
Evan D. Rosen and Ormond A. MacDougald
Nature Reviews Molecular Cell Biology 7, 885–896
(December 2006); doi:10.1038/nrm2066
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article
Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608
Feng Zhang, Lance R Thomas, Eugene M Oltz & Thomas M Aune
Nature Immunology 7, 1309–1316
(December 2006); doi:10.1038/ni1397
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news and views
Fetal thymocyte development: putting a zinc finger on it?
Andrea C Carpenter & Craig H Bassing
Nature Immunology 7, 1285–1286
(December 2006); doi:10.1038/ni1206-1285
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article
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS
Ya Dai, Hidenori Taru, Scott L Deken, Brock Grill, Brian Ackley, Michael L Nonet & Yishi Jin
Nature Neuroscience 9, 1479–1487
(December 2006); doi:10.1038/nn1808
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letter
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
Kunikazu Tsuji, Amitabha Bandyopadhyay, Brian D Harfe, Karen Cox, Sanjeev Kakar, Louis Gerstenfeld, Thomas Einhorn, Clifford J Tabin & Vicki Rosen
Nature Genetics 38, 1424–1429
(December 2006); doi:10.1038/ng1916
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letter
Self-incompatibility in Papaver targets soluble inorganic pyrophosphatases in pollen
Barend H. J. de Graaf, Jason J. Rudd, Michael J. Wheeler, Ruth M. Perry, Elizabeth M. Bell, Kim Osman, F. Christopher H. Franklin and Vernonica E. Franklin-Tong
Nature 444, 490–493
(23 November 2006); doi:10.1038/nature05311
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review
Auxin in action: signalling, transport and the control of plant growth and development
William D. Teale, Ivan A. Paponov and Klaus Palme
Nature Reviews Molecular Cell Biology 7, 847–859
(November 2006); doi:10.1038/nrm2020
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article
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal & Steven A Goldman
Nature Medicine 12, 1259–1268
(November 2006); doi:10.1038/nm1495
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brief communication
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
Bettina Lorenz-Depiereux, Murat Bastepe, Anna Benet-Pagès, Mustapha Amyere, Janine Wagenstaller, Ursula Müller-Barth, Klaus Badenhoop, Stephanie M Kaiser, Roger S Rittmaster, Alan H Shlossberg, José L Olivares, César Loris, Feliciano J Ramos, Francis Glorieux, Miikka Vikkula, Harald Jüppner & Tim M Strom
Nature Genetics 38, 1248–1250
(November 2006); doi:10.1038/ng1868
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news and views
Bone talk
Susan C Schiavi
Nature Genetics 38, 1230–1231
(November 2006); doi:10.1038/ng1106-1230
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A protein interaction network for pluripotency of embryonic stem cells
Jianlong Wang, Sridhar Rao, Jianlin Chu, Xiaohua Shen, Dana N. Levasseur, Thorold W. Theunissen and Stuart H. Orkin
Nature 444, 364–368
(16 November 2006); doi:10.1038/nature05284
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letter
Boc is a receptor for sonic hedgehog in the guidance of commissural axons
Ami Okada , Frédéric Charron , Steves Morin, David S. Shin, Karen Wong, Pierre J. Fabre, Marc Tessier-Lavigne and Susan K. McConnell
Nature 444, 369–373
(16 November 2006); doi:10.1038/nature05246
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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
Akiko Takahashi, Naoko Ohtani, Kimi Yamakoshi, Shin-ichi Iida, Hidetoshi Tahara, Keiko Nakayama, Keiichi I. Nakayama, Toshinori Ide, Hideyuki Saya & Eiji Hara
Nature Cell Biology 8, 1291–1297
(November 2006); doi:10.1038/ncb1491
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news and views
ROS as a tumour suppressor?
Matthew R. Ramsey & Norman E. Sharpless
Nature Cell Biology 8, 1213–1215
(November 2006); doi:10.1038/ncb1106-1213
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article
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development
Yi Gu, Hee-Don Chae, Jamie E Siefring, Aparna C Jasti, David A Hildeman & David A Williams
Nature Immunology 7, 1182–1190
(November 2006); doi:10.1038/ni1396
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letter
R-spondin1 is essential in sex determination, skin differentiation and malignancy
Pietro Parma, Orietta Radi, Valerie Vidal, Marie Christine Chaboissier, Elena Dellambra, Stella Valentini, Liliana Guerra, Andreas Schedl & Giovanna Camerino
Nature Genetics 38, 1304–1309
(November 2006); doi:10.1038/ng1907
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brief communication
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Diana C Blaydon, Yoshiyuki Ishii, Edel A O'Toole, Harriet C Unsworth, Muy-Teck Teh, Franz Rüschendorf, Claire Sinclair, Väinö K Hopsu-Havu, Nicholas Tidman, Celia Moss, Rosemarie Watson, David de Berker, Muhammad Wajid, Angela M Christiano & David P Kelsell
Nature Genetics 38, 1245–1247
(November 2006); doi:10.1038/ng1883
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news and views
R-spondin1 tips the balance in sex determination
Blanche Capel
Nature Genetics 38, 1233–1234
(November 2006); doi:10.1038/ng1106-1233
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review
Orchestrating ontogenesis: variations on a theme by sonic hedgehog
Philip W. Ingham and Marysia Placzek
Nature Reviews Genetics 7, 841–850
(November 2006); doi:10.1038/nrg1969
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review
Reelin, lipoprotein receptors and synaptic plasticity
Joachim Herz and Ying Chen
Nature Reviews Neuroscience 7, 850–859
(November 2006); doi:10.1038/nrn2009
| Summary | Full Text (HTML / PDF) |

review
Regulation of cell fate in the sensory epithelia of the inner ear
Matthew W. Kelley
Nature Reviews Neuroscience 7, 837–849
(November 2006); doi:10.1038/nrn1987
| Summary | Full Text (HTML / PDF) |

article
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm
Valerie Gouon-Evans, Lise Boussemart, Paul Gadue, Dirk Nierhoff, Christoph I Koehler, Atsushi Kubo, David A Shafritz & Gordon Keller
Nature Biotechnology 24, 1402–1411
(November 2006); doi:10.1038/nbt1258
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review
Polycomb silencers control cell fate, development and cancer
Anke Sparmann and Maarten van Lohuizen
Nature Reviews Cancer 6, 846–856
(November 2006); doi:10.1038/nrc1991
| Summary | Full Text (HTML / PDF) |

article
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
Rebecca J Richardson, Jill Dixon, Saimon Malhotra, Matthew J Hardman, Lynnette Knowles, Ray P Boot-Handford, Paul Shore, Alan Whitmarsh & Michael J Dixon
Nature Genetics 38, 1329–1334
(November 2006); doi:10.1038/ng1894
| Summary | Full Text (HTML / PDF) |

article
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Diana C Blaydon, Yoshiyuki Ishii, Edel A O'Toole, Harriet C Unsworth, Muy-Teck Teh, Franz Rüschendorf, Claire Sinclair, Väinö K Hopsu-Havu, Nicholas Tidman, Celia Moss, Rosemarie Watson, David de Berker, Muhammad Wajid, Angela M Christiano & David P Kelsell
Nature Genetics 12, 1301–1309
(November 2006); doi:10.1038/ng1883
| Summary | Full Text (HTML / PDF) |

letter
Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya
Isao Oishi, Yasuhiko Kawakami, Ángel Raya, Carles Callol-Massot & Juan Carlos Izpisúa Belmonte
Nature Genetics 38, 1316–1322
(November 2006); doi:10.1038/ng1892
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article
Insights into social insects from the genome of the honeybee Apis mellifera
The Honeybee Genome Sequencing Consortium et al.
Nature 443, 931–949
(26 October 2006); doi:10.1038/nature05260
| Summary | Full Text (HTML / PDF) |

news and views
Genomics: How to make a social insect
Edward O. Wilson
Nature 443, 919–920
(26 October 2006); doi:10.1038/443919a
| Full Text (HTML / PDF) |

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Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity
Basile Tarchini, Denis Duboule and Marie Kmita
Nature 443, 985–988
(26 October 2006); doi:10.1038/nature05247
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review
Receptor editing in lymphocyte development and central tolerance
David Nemazee
Nature Reviews Immunology 6, 728–740
(October 2006); doi:10.1038/nri1939
| Summary | Full Text (HTML / PDF) |

article
Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones
Karen Y Wu, Jonathan H Zippin, David R Huron, Margarita Kamenetsky, Ulrich Hengst, Jochen Buck, Lonny R Levin & Samie R Jaffrey
Nature Neuroscience 9, 1257–1264
(September 2006); doi:10.1038/nn1767
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review
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
Marc Fuccillo, Alexandra L. Joyner and Gord Fishell
Nature Reviews Neuroscience 9, 772–783
(September 2006); doi:10.1038/nrn1990
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The Mg-chelatase H subunit is an abscisic acid receptor
Yuan-Yue Shen, Xiao-Fang Wang, Fu-Qing Wu, Shu-Yuan Du, Zheng Cao, Yi Shang, Xiu-Ling Wang, Chang-Cao Peng, Xiang-Chun Yu, Sai-Yong Zhu, Ren-Chun Fan, Yan-Hong Xu and Da-Peng Zhang
Nature 443, 823–826
(19 October 2006); doi:10.1038/nature05176
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Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
Jinqiu Zhang, Wai-Leong Tam, Guo Qing Tong, Qiang Wu, Hsiao-Yun Chan, Boon-Seng Soh, Yuefei Lou, Jianchang Yang, Yupo Ma, Li Chai, Huck-Hui Ng, Thomas Lufkin, Paul Robson & Bing Lim
Nature Cell Biology 8, 1114–1123
(2006); doi:10.1038/ncb1481
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article
Surface-bound chemokines capture and prime T cells for synapse formation
Rachel S Friedman, Jordan Jacobelli & Matthew F Krummel
Nature Immunology 7, 1101–1108
(2006); doi:10.1038/ni1384
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article
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Jacob Hanna, Debra Goldman-Wohl, Yaron Hamani, Inbal Avraham, Caryn Greenfield, Shira Natanson-Yaron, Diana Prus, Leonor Cohen-Daniel, Tal I Arnon, Irit Manaster, Roi Gazit, Vladimir Yutkin, Daniel Benharroch, Angel Porgador, Eli Keshet, Simcha Yagel & Ofer Mandelboim
Nature Medicine 12, 1065–1074
( 2006); doi:10.1038/nm1452
| Summary | Full Text (HTML / PDF) |

news and views
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
Meghana M Kulkarni, Matthew Booker, Serena J Silver, Adam Friedman, Pengyu Hong, Norbert Perrimon & Bernard Mathey-Prevot
Nature Methods 3, 833–838
(2006); doi:10.1038/nmeth935
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article
Role of Bax and Bak in mitochondrial morphogenesis
Mariusz Karbowski, Kristi L. Norris, Megan M. Cleland, Seon-Yong Jeong and Richard J. Youle
Nature 443, 658–662
(12 October 2006); doi:10.1038/nature05111
| Summary | Full Text (HTML / PDF) |

review
Receptor editing in lymphocyte development and central tolerance
David Nemazee
Nature Reviews Immunology 7, 728–740
(2006); doi:10.1038/nri1939
| Summary | Full Text (HTML / PDF) |

brief communication
Local caspase activity directs engulfment of dendrites during pruning
Darren W Williams, Shu Kondo, Agnieszka Krzyzanowska, Yasushi Hiromi & James W Truman
Nature Neuroscience 9, 1234–1236
(2006); doi:10.1038/nn1774
| Summary | Full Text (HTML / PDF) |

letter
Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos
Fumio Motegi & Asako Sugimoto
Nature Cell Biology 8, 978–985
(September 2006); doi:10.1038/ncb1459
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article
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface
Silvia Cappello, Alessio Attardo, Xunwei Wu, Takuji Iwasato, Shigeyoshi Itohara, Michaela Wilsch-Bräuninger, Hanna M Eilken, Michael A Rieger, Timm T Schroeder, Wieland B Huttner, Cord Brakebusch & Magdalena Götz
Nature Neuroscience 9, 1099–1107
(September 2006); doi:10.1038/nn1744
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letter
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula
Kevin M. Vogeli, Suk-Won Jin, Gail R. Martin and Didier Y. R. Stainier
Nature 443, 337–339
(21 September 2006); doi:10.1038/nature05045
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review
Notch signalling: a simple pathway becomes complex
Sarah J. Bray
Nature Reviews Molecular Cell Biology 7, 678–689
(September 2006); doi:10.1038/nrm2009
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letter
Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad
Lilach Gilboa and Ruth Lehmann
Nature 443, 97–100
(7 September 2006); doi:10.1038/nature05068
| Summary | Full Text (HTML / PDF) |

article
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
Marcel Batten, Ji Li, Sothy Yi, Noelyn M Kljavin, Dimitry M Danilenko, Sophie Lucas, James Lee, Frederic J de Sauvage & Nico Ghilardi
Nature Immunology 7, 929–936
(13 August 2006); doi:10.1038/ni1375
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article
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Jason S Stumhofer, Arian Laurence, Emma H Wilson, Elaine Huang, Cristina M Tato, Leanne M Johnson, Alejandro V Villarino, Qiulong Huang, Akihiko Yoshimura, David Sehy, Christiaan J M Saris, John J O'Shea, Lothar Hennighausen, Matthias Ernst & Christopher A Hunter
Nature Immunology 7, 937–945
(13 August 2006); doi:10.1038/ni1376
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news and views
All in the family: IL-27 suppression of TH-17 cells
John Colgan & Paul Rothmanr
Nature Immunology 7, 899–901
(2006); doi:10.1038/ni0906-899
| Summary | Full Text (HTML / PDF) |

letter
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
Ayumu Tashiro, Vladislav M. Sandler, Nicolas Toni, Chunmei Zhao and Fred H. Gage
Nature 442, 929–933
(24 August 2006); doi:10.1038/nature05028
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article
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
Jolanta M Topczewska, Lynne-Marie Postovit, Naira V Margaryan, Anthony Sam, Angela R Hess, William W Wheaton, Brian J Nickoloff, Jacek Topczewski & Mary J C Hendrix
Nature Medicine 12, 925–932
(10 August 2006); doi:10.1038/nm1448
| Summary | Full Text (HTML / PDF) |

letter
Mesodermal Wnt2b signalling positively regulates liver specification
Elke A. Ober, Heather Verkade, Holly A. Field and Didier Y. R. Stainier
Nature 442, 688–691
(10 August 2006); doi:10.1038/nature04888
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letter
Endothelial tubes assemble from intracellular vacuoles in vivo
Makoto Kamei, W. Brian Saunders, Kayla J. Bayless, Louis Dye, George E. Davis and Brant M. Weinstein
Nature 442, 453–456
(27 July 2006); doi:10.1038/nature04923
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news and views
Developmental biology: The hole picture
Keith Mostov and Fernando Martin-Belmonte
Nature 442, 363–364
(27 July 2006); doi:10.1038/442363a
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article
Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases
Anouk Caraux, Qingxian Lu, Nadine Fernandez, Sylvain Riou, James P Di Santo, David H Raulet, Greg Lemke & Claude Roth
Nature Immunology 7, 747–754
(June 2006); doi:10.1038/ni1353
| Summary | Full Text (HTML / PDF) |

news and views
NK cell development: Gas matters
Thierry Walzer & Eric Vivier
Nature Immunology 7, 702–704
(July 2006); doi:10.1038/ni0706-702
| Summary | Full Text (HTML / PDF) |

article
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Betty Y Y Tam, Kevin Wei, John S Rudge, Jana Hoffman, Joceyln Holash, Sang-ki Park, Jenny Yuan, Colleen Hefner, Cecile Chartier, Jeng-Shin Lee, Shelly Jiang, Nihar R Niyak, Frans A Kuypers, Lisa Ma, Uma Sundram, Grace Wu, Joseph A Garcia, Stanley L Schrier, Jacquelyn J Maher, Randall S Johnson, George D Yancopoulos, Richard C Mulligan & Calvin J Kuo
Nature Medicine 7, 793–800
(July 2006); doi:10.1038/nm1428
| Summary | Full Text (HTML / PDF) |

news and views
VEGF inhibitors make blood
Christian Fischer, Peter Carmeliet & Edward M Conway
Nature Medicine 7, 732–734
(July 2006); doi:10.1038/nm0706-732
| Summary | Full Text (HTML / PDF) |

article
Midline radial glia translocation and corpus callosum formation require FGF signaling
Karen Müller Smith, Yasushi Ohkubo, Maria Elisabetta Maragnoli, Mladen-Roko Ras caronin, Michael L Schwartz, Nenad S caronestan & Flora M Vaccarino
Nature Neuroscience 9, 787 - 797
(June 2006); doi:10.1038/nn1705
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letter
Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
Patricia M. White, Angelika Doetzlhofer, Yun Shain Lee, Andrew K. Groves and Neil Segil
Nature 441, 984–987
(22 June 2006); doi:10.1038/nature04849
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Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium
Simona W. Rossi, William E. Jenkinson, Graham Anderson and Eric J. Jenkinson
Nature 441, 988–991
(22 June 2006); doi:10.1038/nature04813
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article
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
Valérie Senée, Claude Chelala, Sabine Duchatelet, Daorong Feng, Hervé Blanc, Jack-Christophe Cossec, Céline Charon, Marc Nicolino, Pascal Boileau, Douglas R Cavener, Pierre Bougnères, Doris Taha & Cécile Julier
Nature Genetics 38, 682 - 687
(June 2006); doi:10.1038/ng1802
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article
Noise-resistant and synchronized oscillation of the segmentation clock
Kazuki Horikawa, Kana Ishimatsu, Eiichi Yoshimoto, Shigeru Kondo and Hiroyuki Takeda
Nature 441, 719–723
(08 June 2006); doi:10.1038/nature04861
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letter
Social interactions among epithelial cells during tracheal branching morphogenesis
Amin S. Ghabrial and Mark A. Krasnow
Nature 441, 746–749
(08 June 2006); doi:10.1038/nature04829
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letter
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Yousang Gwack, Sonia Sharma, Julie Nardone, Bogdan Tanasa, Alina Iuga, Sonal Srikanth, Heidi Okamura, Diana Bolton, Stefan Feske, Patrick G. Hogan and Anjana Rao
Nature 441, 646–650
(01 June 2006); doi:10.1038/nature04631
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news and views
Down's syndrome: Critical genes in a critical region
Charles J. Epstein
Nature 441, 582–583
(01 June 2006); doi:10.1038/441582a
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letter
Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos
Rosana Muñoz, Mauricio Moreno, Carlos Oliva, Claudio Orbenes & Juan Larraín
Nature Cell Biology 8, 492–500
(May 2006); doi:10.1038/ncb1399
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letter
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Laurie A. Boyer, Kathrin Plath , Julia Zeitlinger, Tobias Brambrink, Lea A. Medeiros, Tong Ihn Lee, Stuart S. Levine, Marius Wernig, Adriana Tajonar, Mridula K. Ray, George W. Bell, Arie P. Otte, Miguel Vidal, David K. Gifford, Richard A. Young and Rudolf Jaenisch
Nature 441, 349–353
(18 May 2006); doi:10.1038/nature04733
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Specification of the neural crest occurs during gastrulation and requires Pax7
Martín L. Basch, Marianne Bronner–Fraser and Martín I. García–Castro
Nature 441, 218–222
(11 May 2006); doi:10.1038/nature04684
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Transforming growth factor–ß induces development of the TH17 lineage
Paul R. Mangan, Laurie E. Harrington, Darrell B. O'Quinn, Whitney S. Helms, Daniel C. Bullard, Charles O. Elson, Robin D. Hatton, Sharon M. Wahl, Trenton R. Schoeb and Casey T. Weaver
Nature 441, 231–234
(11 May 2006); doi:10.1038/nature04754
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Estelle Bettelli, Yijun Carrier, Wenda Gao, Thomas Korn, Terry B. Strom, Mohamed Oukka, Howard L. Weiner and Vijay K. Kuchroo
Nature 441, 235–238
(11 May 2006); doi:10.1038/nature04753
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news and views
Immunology: What does it mean to be just 17?
Cristina M. Tato and John J. O'Shea
Nature 441, 166–168
(11 May 2006); doi:10.1038/441166a
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review article
Mesoderm induction: from caps to chips
David Kimelman
Nature Reviews Genetics 7, 360–372
(May 2006); doi:10.1038/nrg1837
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article
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
Stephane Angers, Chris J. Thorpe, Travis L. Biechele, Seth J. Goldenberg, Ning Zheng, Michael J. MacCoss & Randall T. Moon
Nature Cell Biology 8, 348–357
(April 2006); doi:10.1038/ncb1381
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Early hematopoietic lineage restrictions directed by Ikaros
Toshimi Yoshida, Samuel Yao-Ming Ng, Juan Carlos Zuniga-Pflucker & Katia Georgopoulos
Nature Immunology 7, 382–391
(April 2006); doi:10.1038/ni1314
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news and views
Hematopoiesis flies high with Ikaros
Stephen T Smale & Kenneth Dorshkind
Nature Immunology 7, 367–369
(April 2006); doi:10.1038/ni0406-367
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review article
Left-right asymmetry in the vertebrate embryo: from early information to higher-level integration
Ángel Raya and Juan Carlos Izpisúa Belmonte
Nature Reviews Genetics 7, 283–293
(April 2006); doi:10.1038/nrg1830
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article
Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein
Osamu Muraoka, Takashi Shimizu, Taijiro Yabe, Hideaki Nojima, Young-Ki Bae, Hisashi Hashimoto & Masahiko Hibi
Nature Cell Biology 8, 329–340
(2006); doi:10.1038/ncb1379
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The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation
Irina Naguibneva, Maya Ameyar-Zazoua, Anna Polesskaya, Slimane Ait-Si-Ali, Reguina Groisman, Mouloud Souidi, Sylvain Cuvellier & Annick Harel-Bellan
Nature Cell Biology 8, 278–284
(30 March 2006); doi:10.1038/ncb1373
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article
Silencing of EphA3 through a cis interaction with ephrinA5
Ricardo F Carvalho, Martin Beutler, Katharine J M Marler, Bernd Knöll, Elena Becker-Barroso, R Heintzmann, Tony Ng & Uwe Drescher
Nature Neuroscience 9, 322–330
(March 2006); doi:10.1038/nn1655
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An excitable gene regulatory circuit induces transient cellular differentiation
Gürol M. Süel, Jordi Garcia-Ojalvo, Louisa M. Liberman and Michael B. Elowitz
Nature 440, 545–550
(23 March 2006); doi:10.1038/nature04588
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