letters to nature Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c
Avirup Bose, Adilson Guilherme, Stacey I. Robida, Sarah M. C. Nicoloro, Qiong L. Zhou, Zhen Y. Jiang, Darcy P. Pomerleau and Michael P. Czech Nature420, 821–824
(19 December 2002); doi:10.1038/nature01246
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article β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
Simona Frigerio, Tobias Junt, Bao Lu, Craig Gerard, Urs Zumsteg, Georg A. Holländer and Luca Piali Nature Medicine8, 1414–1420
(December 2002); doi:10.1038/nm792
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article Hypothalamic insulin signaling is required for inhibition of glucose production
Silvana Obici, Bei B. Zhang, George Karkanias and Luciano Rossetti Nature Medicine8, 1376–1382
(December 2002); doi:10.1038/nm798
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November
letters to nature A central role for JNK in obesity and insulin resistance
Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z. Görgün, K. Teoman Uysal, Kazuhisa Maeda, Michael Karin and Gökhan S. Hotamisligil Nature420, 333–336
(21 November 2002); doi:10.1038/nature01137
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article Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, S. Kita, K. Ueki, K. Eto, Y. Akanuma, P. Froguel, F. Foufelle, P. Ferre, D. Carling, S. Kimura, R. Nagai, B.B. Kahn and T. Kadowaki Nature Medicine8, 1288–1295
(November 2002); doi:10.1038/nm788
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October
article A futile metabolic cycle activated in adipocytes by antidiabetic agents
Hong-Ping Guan, Yong Li, Mette Valentin Jensen, Christopher B. Newgard, Claire M. Steppan and Mitchell A. Lazar Nature Medicine8, 1122–1128
(October 2002); doi:10.1038/nm780
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article Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
Jun Nakae, William H. Biggs, III Tadahiro Kitamura, Webster K. Cavenee, Christopher V.E. Wright, Karen C. Arden and Domenico Accili Nature Genetics32, 245–253
(October 2002); doi:10.1038/ng890
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review article Structural biology of insulin and IGF1 receptors: implications for drug design
Pierre De Meyts and Jonathan Whittaker Nature Reviews Drug Discovery1, 769–783
(October 2002); doi:10.1038/nrd917
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September
review article Protein tyrosine phosphatase 1B inhibitors for diabetes
Theodore O. Johnson, Jacques Ermolieff and Michael R. Jirousek Nature Reviews Drug Discovery1, 696–709
(September 2002); doi:10.1038/nrd895
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article TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu and Kun-Liang Guan Nature Cell Biology4, 648–657
(September 2002); doi:10.1038/ncb839
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article Akt regulates growth by directly phosphorylating Tsc2
Christopher J. Potter, Laura G. Pedraza and Tian Xu Nature Cell Biology4, 658–665
(September 2002); doi:10.1038/ncb840
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brief communication Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
Xinsheng Gao, Yong Zhang, Peter Arrazola, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Binggeng Ru and Duojia Pan Nature Cell Biology4, 699–704
(September 2002); doi:10.1038/ncb847
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news and views TSC1-TSC2: a complex tale of PKB-mediated S6K regulation
Edward J. McManus and Dario R. Alessi Nature Cell Biology4, E214
(September 2002); doi:10.1038/ncb0902-e214
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August
review article Genetic approaches to studying energy balance: perception and integration
Gregory S. Barsh and Michael W. Schwartz Nature Reviews Genetics3, 589–600
(August 2002); doi:10.1038/nrg862
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article Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Beth Borowsky, Margaret M. Durkin, Kristine Ogozalek, Mohammad R. Marzabadi, John DeLeon, Rainer Heurich, Harvey Lichtblau, Zoya Shaposhnik, Irena Daniewska, Thomas P. Blackburn, Theresa A. Branchek, Christophe Gerald, Pierre J. Vaysse and Carlos Forray Nature Medicine8, 825–830
(August 2002); doi:10.1038/nm741
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news and views Rats lighten up with MCH antagonist
Michael W. Schwartz and Richard W. Gelling Nature Medicine8, 779–781
(August 2002); doi:10.1038/nm0802-779
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letter Digenic inheritance of severe insulin resistance in a human pedigree
David B. Savage, Maura Agostini, Inês Barroso, Mark Gurnell, Jian'an Luan, Aline Meirhaeghe, Anne-Helen Harding, Gudrun Ihrke, Odelia Rajanayagam, Maria A. Soos, Stella George, Dirk Berger, E. Louise Thomas, Jimmy D. Bell, Karim Meeran, Richard J. Ross, Antonio Vidal-Puig, Nicholas J. Wareham, Stephen O'Rahilly, V. Krishna K. Chatterjee and Alan J. Schafer Nature Genetics31, 379–384
(August 2002); doi:10.1038/ng926
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letters to nature Gut hormone PYY3-36 physiologically inhibits food intake
Rachel L. Batterham, Michael A. Cowley , Caroline J. Small, Herbert Herzog, Mark A. Cohen, Catherine L. Dakin, Alison M. Wren, Audrey E. Brynes, Malcolm J. Low, Mohammad A. Ghatei, Roger D. Cone and Stephen R. Bloom Nature418, 650–654
(8 August 2002); doi:10.1038/nature00887
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news and views Obesity: Keeping hunger at bay
Michael W. Schwartz and Gregory J. Morton Many different hormones control our weight and appetite. The discovery of another hormone, which suppresses appetite for up to 12 hours, may lead to a better understanding of this complex control system. Nature418, 595–597
(8 August 2002); doi:10.1038/418595a
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letter Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
Norihide Yokoi, Kajuro Komeda, He-Yao Wang, Hideki Yano, Kazuhiro Kitada, Yuka Saitoh, Yutaka Seino, Kazuki Yasuda, Tadao Serikawa and Susumu Seino Nature Genetics31, 391–394
(August 2002); doi:10.1038/ng927
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brief communication A phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
Allan Z. Zhao, Jjing-Ning Huan, Sandhya Gupta, Rekha Pal and Abhiram Sahu Nature Neuroscience5, 727–728
(August 2002); doi:10.1038/nn885
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review article Organogenesis: Pancreatic organogenesis — developmental mechanisms and implications for therapy
Helena Edlund Nature Reviews Genetics3, 524–532
(July 2002); doi:10.1038/nrg841
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June
article Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Silvana Obici, Zhaohui Feng, George Karkanias, Denis G. Baskin and Luciano Rossetti Nature Neuroscience5, 566–572
(June 2002); doi:10.1038/nn861
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May
letters to nature Transcription coactivator TRAP220 is required for PPARg2-stimulated adipogenesis
Kai Ge, Mohamed Guermah, Chao-Xing Yuan, Mitsuhiro Ito, Annika E. Wallberg, Bruce M. Spiegelman and Robert G. Roeder Nature 417, 563–567
(May 2002); doi:10.1038/417563a
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letter β-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass
Rohit N. Kulkarni, Martin Holzenberger, David Q. Shih, Umut Ozcan, Markus Stoffel, Mark A. Magnuson and C. Ronald Kahn Nature Genetics31, 111–115
(May 2002); doi:10.1038/ng872
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article Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis
M. B. Pepys, J. Herbert, W. L. Hutchinson, G. A. Tennent, H. J. Lachmann, J. R. Gallimore, L. B. Lovat, T. Bartfai, A. Alanine, C. Hertel, T. Hoffmann, R. Jakob-Roetne, R. D. Norcross, J. A. Kemp, K. Yamamura, M. Suzuki, G. W. Taylor, S. Murray, D. Thompson, A. Purvis, S. Kolstoe, S. P. Wood and P. N. Hawkins Nature 417, 254–259
(May 2002); doi:10.1038/417254a
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news and views Amyloid diseases: Small drugs lead the attack
Leslie Iversen Nature 417, 231–233
(May 2002); doi:10.1038/417231a
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April
letter Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
Seung K. Kim, Licia Selleri, Joon S. Lee, Andrew Y. Zhang, Xueying Gu, Yakop Jacobs and Michael L. Cleary Nature Genetics30, 430–435
(April 2002); doi:10.1038/ng860
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news and views Block the FAS, lose the fat
Charles V. Mobbs and Hideo Makimura Nature Medicine8, 335–336
(April 2002); doi:10.1038/nm0402-335
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news and views Type 1 diabetes: virus infection or autoimmune disease?
DeLisa Fairweather and Noel R. Rose Nature Immunology3, 338–340
(April 2002); doi:10.1038/ni0402-338
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article Target cell defense prevents the development of diabetes after viral infection
Malin Flodström, Amy Maday, Deepika Balakrishna, Mary Malo Cleary, Akihiko Yoshimura and Nora Sarvetnick Nature Immunology3, 373–382
(April 2002); doi:10.1038/ni771
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article Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera
Sofia Casares, Alicia Hurtado, Robert C. McEvoy, Adelaida Sarukhan, Harald von Boehmer and Teodor-Doru Brumeanu Nature Immunology3, 383–391
(April 2002); doi:10.1038/ni770
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review article OBESITY THERAPY: ALTERING THE ENERGY INTAKE-AND-EXPENDITURE BALANCE SHEET
Vivion E. F. Crowley, Giles S. H. Yeo and Stephen O'Rahilly Nature Reviews Drug Discovery1, 276–286
(April 2002); doi:10.1038/nrd770
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review article REGULATED TRANSPORT OF THE GLUCOSE TRANSPORTER GLUT4
Nia J. Bryant, Roland Govers and David E. James Nature Reviews Molecular Cell Biology3, 267–277
(April 2002); doi:10.1038/nrm782
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letters to nature Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
Finny G. Kuruvilla, Alykhan F. Shamji, Scott M. Sternson, Paul J. Hergenrother and Stuart L. Schreiber Nature 416, 653–657
(April 2002); doi:10.1038/416653a
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March
article CEACAM1 regulates insulin clearance in liver
Matthew N. Poy, Yan Yang, Khadijeh Rezaei, Mats A. Fernström, Abraham D. Lee, Yoshiaki Kido, Sandra K. Erickson and Sonia M. Najjar Nature Genetics 30, 270–276
(March 2002); doi:10.1038/ng840
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February
letter Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
Toshimasa Yamauchi, Yuichi Oike, Junji Kamon, Hironori Waki, Kajuro Komeda, Atsuko Tsuchida, Yukari Date, Meng-Xian Li, Hiroshi Miki, Yasuo Akanuma, Ryozo Nagai, Satoshi Kimura, Takeyori Saheki, Masamitsu Nakazato, Takeshi Naitoh, Kenichi Yamamura and Takashi Kadowaki Nature Genetics 30, 221–226
(February 2002); doi:10.1038/ng829
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January
article Interleukin-6-deficient mice develop mature-onset obesity
Ville Wallenius, Kristina Wallenius, Bo Ahrén, Mats Rudling, Hans Carlsten, Suzanne L. Dickson, Claes Ohlsson and John-Olov Jansson Nature Medicine8, 75–79
(January 2002); doi:10.1038/nm0102-75
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news and views Diabetes: Fat in all the wrong places
Jeffrey Friedman Nature 415, 268–269
(January 2002); doi:10.1038/415268a
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letters to nature Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Yasuhiko Minokoshi, Young-Bum Kim, Odile D. Peroni, Lee G. D. Fryer, Corinna Müller, David Carling and Barbara B. Kahn Nature 415, 339–343
(January 2002); doi:10.1038/415339a
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