review article Neuropeptide gene polymorphisms and human behavioural disorders
Akio Inui Nature Reviews Drug Discovery2, 986–998
(December 2003); doi:10.1038/nrd1252
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brief communication Genetics: Influence of TOR kinase on lifespan in C. elegans
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L. Kovacs, László Orosz and Fritz Müller Nature426, 620
(11 December 2003); doi:10.1038/426620a
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review article Opportunities in somatostatin research: biological, chemical and therapeutic aspects
Gisbert Weckbecker, Ian Lewis, Rainer Albert, Herbert A. Schmid, Daniel Hoyer and Christian Bruns Nature Reviews Drug Discovery2, 999–1017
(December 2003); doi:10.1038/nrd1255
| Abstract | Full Text (HTML / PDF) |
article Muscle-specific Pparg deletion causes insulin resistance
Andrea L Hevener, Weimin He, Yaacov Barak, Jamie Le, Gautam Bandyopadhyay, Peter Olson, Jason Wilkes, Ronald M Evans and Jerrold Olefsky Nature Medicine9, 1491–1497
(December 2003); doi:10.1038/nm956
| Abstract | Full Text (HTML/PDF) |
November
news and views A TUG on glucose transport
Alan R Saltiel Nature Medicine9, 1352
(November 2003); doi:10.1038/nm1103-1352
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letters to nature Testis determination requires insulin receptor family function in mice
Serge Nef , Sunita Verma-Kurvari, Jussi Merenmies, Jean-Dominique Vassalli, Argiris Efstratiadis, Domenico Accili and Luis F. Parada Nature426, 291–295
(20 November 2003); doi:10.1038/nature02059
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news and views Developmental biology: Gender benders
Peter Koopman Nature426, 241
(20 November 2003); doi:10.1038/426241a
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article Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
Alberto Sánchez-Fueyo, Jane Tian, Dominic Picarella, Christoph Domenig, Xin Xiao Zheng, Catherine A. Sabatos, Natasha Manlongat, Orissa Bender, Thomas Kamradt, Vijay K. Kuchroo, José-Carlos Gutiérrez-Ramos, Anthony J. Coyle and Terry B. Strom Nature Immunology4, 1093–1101
(November 2003); doi:10.1038/ni987
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article Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
Catherine A Sabatos, Sumone Chakravarti, Eugene Cha, Anna Schubart, Alberto Sánchez-Fueyo, Xin Xiao Zheng, Anthony J. Coyle, Terry B. Strom, Gordon J. Freeman and Vijay K. Kuchroo Nature Immunology4, 1102–1110
(November 2003); doi:10.1038/ni988
| Abstract | Full Text (HTML/PDF) |
news and views I-Tim-izing the pathways of counter-regulation
Marsha Wills-Karp, Yasmine Belkaid and Christopher L. Karp Nature Immunology4, 1050–1052
(November 2003); doi:10.1038/ni1103-1050
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letters to nature CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ
Stephan Herzig, Susan Hedrick, Ianessa Morantte, Seung-Hoi Koo, Francesco Galimi and Marc Montminy Nature426, 190–193
(13 November 2003); doi:10.1038/nature02110
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news and views Setting fat on fire
Robert Walczak and Peter Tontonoz Nature Medicine9, 1348–1349
(November 2003); doi:10.1038/nm1103-1348
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review article Monitoring of stored and available fuel by the CNS: implications for obesity
Randy J. Seeley and Stephen C. Woods Nature Reviews Neuroscience4, 901–909
(November 2003); doi:10.1038/nrn1245
| Summary | Full Text (HTML / PDF) |
October
letters to nature A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
Anne-Sophie Van Laere, Minh Nguyen, Martin Braunschweig, Carine Nezer, Catherine Collette, Laurence Moreau, Alan L. Archibald, Chris S. Haley, Nadine Buys, Michael Tally, Göran Andersson, Michel Georges and Leif Andersson Nature425, 832–836
(23 October 2003); doi:10.1038/nature02064
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news and views Genetics: Secret of a porkie porker
Chris Gunter Nature425, 777–778
(23 October 2003); doi:10.1038/425777b
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letters to nature Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking
Jonathan S. Bogan , Natalie Hendon, Adrienne E. McKee, Tsu-Shuen Tsao and Harvey F. Lodish Nature425, 727–733
(16 October 2003); doi:10.1038/nature01989
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news and views Eat your proteins—live longer
Evelyn Jabri Nature Structural Biology10, 780
(October 2003); doi:10.1038/nsb1003-780
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September
article Cidea-deficient mice have lean phenotype and are resistant to obesity
Zhihong Zhou, Shen Yon Toh, Zhengming Chen, Ke Guo, Chee Peng Ng, Sathivel Ponniah, Sheng-Cai Lin, Wanjin Hong and Peng Li Nature Genetics35, 49–56
(September 2003); doi:10.1038/ng1225
| Abstract | Full Text (HTML/PDF) |
article TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
Mériam Belghith, Jeffrey A. Bluestone, Samia Barriot, Jérome Mégret, Jean-François Bach and Lucienne Chatenoud Nature Medicine9, 1202–1208
(September 2003); doi:10.1038/nm924
| Abstract | Full Text (HTML/PDF) |
letters to nature Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α
Jin Fu, Silvana Gaetani, Fariba Oveisi, Jesse Lo Verme, Antonia Serrano, Fernando Rodríguez de Fonseca, Anja Rosengarth, Hartmut Luecke, Barbara Di Giacomo, Giorgio Tarzia and Daniele Piomelli Nature425, 90–93
(04 September 2003); doi:10.1038/nature01921
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article Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
Matthew J. During, Lei Cao, David S. Zuzga, Jeremy S. Francis, Helen L. Fitzsimons, Xiangyang Jiao, Ross J. Bland, Matthias Klugmann, William A. Banks, Daniel J. Drucker and Colin N. Haile Nature Medicine9, 1173–1179
(September 2003); doi:10.1038/nm919
| Abstract | Full Text (HTML/PDF) |
news and views Learning from the gut
Mark P. Mattson, Tracy Ann Perry and Nigel H. Greig Nature Medicine9, 1113–1115
(September 2003); doi:10.1038/nm0903-1113
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August
letters to nature BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Nika N. Danial, Colette F. Gramm, Luca Scorrano, Chen-Yu Zhang, Stefan Krauss, Ann M. Ranger, Sandeep Robert Datta, Michael E. Greenberg, Lawrence J. Licklider, Bradford B. Lowell, Steven P. Gygi and Stanley J. Korsmeyer Nature424, 952–956
(21 August 2003); doi:10.1038/nature01825
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news and views Cell biology: Metabolism meets death
Julian Downward Nature424, 896–897
(21 August 2003); doi:10.1038/424896a
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article Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor-null mice
Carlos Bernal-Mizrachi, Sherry Weng, Chu Feng, Brian N. Finck, Russell H. Knutsen, Teresa C. Leone, Trey Coleman, Robert P. Mecham, Daniel P. Kelly and Clay F. Semenkovich Nature Medicine9, 1069–1075
(August 2003); doi:10.1038/nm898
| Abstract | Full Text (HTML/PDF) |
July
article Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li and Cynthia Kenyon Nature424, 277–283
(17 July 2003); doi:10.1038/nature01789
| Abstract | Full Text (HTML / PDF) |
news and views Ageing: Microarraying mortality
David Gems and Joshua J. McElwee Nature424, 259–261
(17 July 2003); doi:10.1038/424259a
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article Deletion of cytosolic phospholipase A2 promotes striated muscle growth
Syed Haq, Heiko Kilter, Ashour Michael, Jingzang Tao, Eileen O'Leary, Xio Ming Sun, Brian Walters, Kausik Bhattacharya, Xin Chen, Lei Cui, Michele Andreucci, Anthony Rosenzweig, J. Luis Guerrero, Richard Patten, Ronglih Liao, Jeffery Molkentin, Michael Picard, Joseph V. Bonventre and Thomas Force Nature Medicine9, 944–951
(July 2003); doi:10.1038/nm891
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article PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Vamsi K Mootha, Cecilia M Lindgren, Karl-Fredrik Eriksson, Aravind Subramanian, Smita Sihag, Joseph Lehar, Pere Puigserver, Emma Carlsson, Martin Ridderstråle, Esa Laurila, Nicholas Houstis, Mark J Daly, Nick Patterson, Jill P Mesirov, Todd R Golub, Pablo Tamayo, Bruce Spiegelman, Eric S Lander, Joel N Hirschhorn, David Altshuler and Leif C Groop Nature Genetics34, 267–273
(July 2003); doi:10.1038/ng1180
| Abstract | Full Text (HTML/PDF) |
news and views PGC-1α at the crossroads of type 2 diabetes
Alan D Attie and Christina M Kendziorski Nature Genetics34, 244–245
(July 2003); doi:10.1038/ng0703-244
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article Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
Baoji Xu, Evan H Goulding, Keling Zang, David Cepoi, Roger D Cone, Kevin R Jones, Laurence H Tecott and Louis F Reichardt Nature Neuroscience6, 736–742
(July 2003); doi:10.1038/nn1073
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news and views The skinny on neurotrophins
Brent E Wisse and Michael W Schwartz Nature Neuroscience6, 655–656
(July 2003); doi:10.1038/nn0703-655
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June
letter Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
Hugo Stocker, Thomas Radimerski, Benno Schindelholz, Franz Wittwer, Priyanka Belawat, Pierre Daram, Sebastian Breuer, George Thomas and Ernst Hafen Nature Cell Biology5, 559–566
(June 2003); doi:10.1038/ncb995
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letter Rheb promotes cell growth as a component of the insulin/TOR signalling network
Leslie J. Saucedo, Xinsheng Gao, Dominic A. Chiarelli, Ling Li, Duoija Pan and Bruce A. Edgar Nature Cell Biology5, 566–571
(June 2003); doi:10.1038/ncb996
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brief communication Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Yong Zhang, Xinsheng Gao, Leslie J. Saucedo, Binggen Ru, Bruce A. Edgar and Duojia Pan Nature Cell Biology5, 578–581
(June 2003); doi:10.1038/ncb999
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letters to nature Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H. Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai and Takashi Kadowaki Nature423, 762–769
(12 June 2003); doi:10.1038/nature01705
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May
article Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
Hironori Ueda, Joanna M. M. Howson, Laura Esposito, Joanne Heward, Hywel Snook, Giselle Chamberlain, Daniel B. Rainbow, Kara M. D. Hunter, Annabel N. Smith, Gianfranco Di Genova, Mathias H. Herr, Ingrid Dahlman, Felicity Payne, Deborah Smyth, Christopher Lowe, Rebecca C. J. Twells, Sarah Howlett, Barry Healy, Sarah Nutland, Helen E. Rance, Vin Everett, Luc J. Smink, Alex C. Lam, Heather J. Cordell, Neil M. Walker, Cristina Bordin, John Hulme, Costantino Motzo, Francesco Cucca, J. Fred Hess, Michael L. Metzker, Jane Rogers, Simon Gregory, Amit Allahabadia, Ratnasingam Nithiyananthan, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Polly Bingley, Kathleen M. Gillespie, Dag E. Undlien, Kjersti S. Rønningen, Cristian Guja, Constantin Ionescu-Tîrgoviste, David A. Savage, A. Peter Maxwell, Dennis J. Carson, Chris C. Patterson, Jayne A. Franklyn, David G. Clayton, Laurence B. Peterson, Linda S. Wicker, John A. Todd and Stephen C. L. Gough Nature423, 506–511
(29 May 2003); doi:10.1038/nature01621
| Summary | Full Text (HTML / PDF) |
letters to nature Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
Pere Puigserver, James Rhee, Jerry Donovan, Christopher J. Walkey, J. Cliff Yoon, Francesco Oriente, Yukari Kitamura, Jennifer Altomonte, Hengjiang Dong, Domenico Accili and Bruce M. Spiegelman Nature423, 550–555
(29 May 2003); doi:10.1038/nature01667
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April
letter Islet β-cell secretion determines glucagon release from neighbouring α-cells
Hisamitsu Ishihara, Pierre Maechler, Asllan Gjinovci, Pedro-Luis Herrera and Claes B. Wollheim Nature Cell Biology5, 330–335
(April 2003); doi:10.1038/ncb951
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letters to nature The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
Mayumi Inoue, Louise Chang, Joseph Hwang, Shian-Huey Chiang and Alan R. Saltiel Nature422, 629–633
(10 April 2003); doi:10.1038/nature01533
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March
research article An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis
Cecil Chen, Krzysztof J. Grzegorzewski, Steve Barash, Qinghai Zhao, Helmut Schneider, Qi Wang, Mallika Singh, Laurie Pukac, Adam C. Bell, Roxanne Duan, Tim Coleman, Alokesh Duttaroy, Susan Cheng, Jon Hirsch, Linyi Zhang, Yanick Lazard, Carrie Fischer, Melisa Carey Barber, Zhi-Dong Ma, Ya-Qin Zhang, Peter Reavey, Lilin Zhong, Baiqin Teng, Indra Sanyal, Steve M. Ruben, Olivier Blondel and Charles E. Birse Nature Biotechnology21, 294–301
(March 2003); doi:10.1038/nbt795
| Abstract | Full Text (HTML/PDF) |
research news Bringing diabetes therapeutics to the big screen
Leif Groop Nature Biotechnology21, 240–241
(March 2003); doi:10.1038/nbt0303-240
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letters to nature Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Yasuaki Itoh, Yuji Kawamata, Masataka Harada, Makoto Kobayashi, Ryo Fujii, Shoji Fukusumi, Kazuhiro Ogi, Masaki Hosoya, Yasuhiro Tanaka, Hiroshi Uejima, Hideyuki Tanaka, Minoru Maruyama, Rie Satoh, Shoichi Okubo, Hideki Kizawa, Hidetoshi Komatsu, Fumika Matsumura, Yuko Noguchi, Tokuyuki Shinohara, Shuji Hinuma, Yukio Fujisawa and Masahiko Fujino Nature422, 173–176
(13 March 2003); doi:10.1038/nature01478
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news and views Immunology: Fast and feel good?
Vijay K. Kuchroo and Lindsay B. Nicholson Nature422, 27–28
(06 March 2003); doi:10.1038/422027a
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February
review article CD3-specific antibody-induced active tolerance: from bench to bedside
Lucienne Chatenoud Nature Reviews Immunology3, 123–132
(February 2003); doi:10.1038/nri1000
| Summary | Full Text (HTML / PDF) |
article Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive
Shawn Winer, Hubert Tsui, Ambrose Lau, Aihua Song, Xiaomao Li, Roy K. Cheung, Anastazia Sampson, Fatemeh Afifiyan, Alisha Elford, George Jackowski, Dorothy J. Becker, Pere Santamaria, Pamela Ohashi and H -Michael Dosch Nature Medicine9, 198–205
(February 2003); doi:10.1038/nm818
| Abstract | Full Text (HTML/PDF) |
news and views Murder mysteries in type 1 diabetes
Daniel L. Kaufman Nature Medicine9, 161–162
(February 2003); doi:10.1038/nm0203-161
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letters to nature STAT3 signalling is required for leptin regulation of energy balance but not reproduction
Sarah H. Bates, Walter H. Stearns, Trevor A. Dundon, Markus Schubert, Annette W. K. Tso, Yongping Wang, Alexander S. Banks, Hugh J. Lavery, Asma K. Haq, Eleftheria Maratos-Flier, Benjamin G. Neel, Michael W. Schwartz and Martin G. Myers Jr Nature421, 856–859
(20 February 2003); doi:10.1038/nature01388
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original paper Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling
Donglei Zhang and Pnina Brodt Oncogene22, 974–982
(20 February 2003); doi:10.1038/sj.onc.1206197
| Abstract |
January
letters to nature Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
Kaveh Ashrafi, Francesca Y. Chang, Jennifer L. Watts, Andrew G. Fraser, Ravi S. Kamath, Julie Ahringer and Gary Ruvkun Nature421, 268–272
(16 January 2003); doi:10.1038/nature01279
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news and views Functional genomics: RNA sets the standard
Thomas Tuschl Nature421, 220–221
(16 January 2003); doi:10.1038/421220a
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letters to nature IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Martin Holzenberger, Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C. Even, Pascale Cervera and Yves Le Bouc Nature421, 182–187
(09 January 2003); doi:10.1038/nature01298
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news and views Physiology: Cost-free longevity in mice?
Gordon J. Lithgow and Matthew S. Gill Nature421, 125–126
(09 January 2003); doi:10.1038/421125a
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article A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Siu Sylvia Lee, Raymond Y.N. Lee, Andrew G. Fraser, Ravi S. Kamath, Julie Ahringer and Gary Ruvkun Nature Genetics33, 40–48
(January 2003); doi:10.1038/ng1056
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article Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
Hanne B. Rasmussen, Sven Branner, Finn C. Wiberg and Nicolai Wagtmann Nature Structural Biology10, 19–25
(January 2003); doi:10.1038/nsb882
| Abstract | Full Text (HTML/PDF) |
news and views First bite
Mark D. Gorrell Nature Structural Biology10, 3–5
(January 2003); doi:10.1038/nsb0103-3
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