letters to nature Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
Christian Wolfrum, Esra Asilmaz, Edlira Luca, Jeffrey M. Friedman and Markus Stoffel Nature432, 1027–1032
(23 December 2004); doi:10.1038/nature03047
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news and views Diabetes: Outfoxing insulin resistance?
Marc Montminy and Seung-Hoi Koo Nature432, 958–959
(23 December 2004); doi:10.1038/432958a
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letter Mutations in PTF1A cause pancreatic and cerebellar agenesis
Gabrielle S Sellick, Karen T Barker, Irene Stolte-Dijkstra, Christina Fleischmann, Richard J Coleman, Christine Garrett, Anna L Gloyn, Emma L Edghill, Andrew T Hattersley, Peter K Wellauer, Graham Goodwin and Richard S Houlston Nature Genetics36, 1301–1305
(December 2004); doi:10.1038/ng1475
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article Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
Weijia Kong, Jing Wei, Parveen Abidi, Meihong Lin, Satoru Inaba, Cong Li, Yanling Wang, Zizheng Wang, Shuyi Si, Huaining Pan, Shukui Wang, Jingdan Wu, Yue Wang, Zhuorong Li, Jingwen Liu and Jian-Dong Jiang Nature Medicine10, 1344–1351
(December 2004); doi:10.1038/nm1135
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news and views Micromanaging insulin secretion
Craig C Mello and Michael P Czech Nature Medicine10, 1297–1298
(December 2004); doi:10.1038/nm1204-1297
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November
article Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice
Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda and Iichiro Shimomura Nature Medicine10, 1208–1215
(November 2004); doi:10.1038/nm1117
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news and views Turning up the heat in the fat cell
Domenico Accili and Luca Valenti Nature Medicine10, 1168–1169
(November 2004); doi:10.1038/nm1104-1168
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review article Why do cancers have high aerobic glycolysis?
Robert A. Gatenby and Robert J. Gillies Nature Reviews Cancer4, 891–899
(November 2004); doi:10.1038/nrc1478
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brief communication A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
Giles S H Yeo, Chiao-Chien Connie Hung, Justin Rochford, Julia Keogh, Juliette Gray, Shoba Sivaramakrishnan, Stephen O'Rahilly and I Sadaf Farooqi Nature Neuroscience7, 1187–1189
(November 2004); doi:10.1038/nn1336
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letters to nature A pancreatic islet-specific microRNA regulates insulin secretion
Matthew N. Poy, Lena Eliasson, Jan Krutzfeldt, Satoru Kuwajima, Xiaosong Ma, Patrick E. MacDonald, Sébastien Pfeffer, Thomas Tuschl, Nikolaus Rajewsky, Patrik Rorsman and Markus Stoffel Nature432, 226–230
(11 November 2004); doi:10.1038/nature03076
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October
article Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
Elmar Jaeckel, Myra A Lipes and Harald von Boehmer Nature Immunology5, 1028–1035
(October 2004); doi:10.1038/ni1120
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review article Gene therapy for autoimmune diseases: quo vadis?
Yuti Chernajovsky, David J. Gould and Osvaldo L. Podhajcer Nature Reviews Immunology4, 800–811
(October 2004); doi:10.1038/nri1459
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letter Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Dan Kawamori, Taka-aki Matsuoka, Munehide Matsuhisa, Yoshitaka Kajimoto, Hidenori Ichijo, Yoshimitsu Yamasaki and Masatsugu Hori Nature Medicine10, 1128–1132
(October 2004); doi:10.1038/nm1111
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article Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
Reiko Hanada, Hitoshi Teranishi, James Todd Pearson, Mamoru Kurokawa, Hiroshi Hosoda, Nobuhiro Fukushima, Yoshihiko Fukue, Ryota Serino, Hiroaki Fujihara, Yoichi Ueta, Masahito Ikawa, Masaru Okabe, Noboru Murakami, Mikiyasu Shirai, Hironobu Yoshimatsu, Kenji Kangawa and Masayasu Kojima Nature Medicine10, 1067–1073
(October 2004); doi:10.1038/nm1106
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news and views Nutrient sensor links obesity with diabetes risk
Mary-Elizabeth Patti and Barbara B Kahn Nature Medicine10, 1049–1050
(October 2004); doi:10.1038/nm1004-1049
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September
research article Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
Raewyn M Seaberg, Simon R Smukler, Timothy J Kieffer, Grigori Enikolopov, Zeenat Asghar, Michael B Wheeler, Gregory Korbutt and Derek van der Kooy Nature Biotechnology22, 1115–1124
(September 2004); doi:10.1038/nbt1004
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news and views β-cell precursors—a work in progress
Gordon C Weir and Susan Bonner-Weir Nature Biotechnology22, 1095–1096
(September 2004); doi:10.1038/nbt0904-1095
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letters to nature Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
Seung K. Kim and Eric J. Rulifson Nature431, 316–320
(16 September 2004); doi:10.1038/nature02897
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letters to nature Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas Nature431, 200–205
(09 September 2004); doi:10.1038/nature02866
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news and views Cell biology: Regulated self–cannibalism
Daniel J. Klionsky Nature431, 31–32
(02 September 2004); doi:10.1038/431031a
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August
letter A functional variant of SUMO4, a new IkBa modifier, is associated with type 1 diabetes
Dehuang Guo, Manyu Li, Yan Zhang, Ping Yang, Sarah Eckenrode, Diane Hopkins, Weipeng Zheng, Sharad Purohit, Robert H Podolsky, Andrew Muir, Jinzhao Wang, Zheng Dong, Todd Brusko, Mark Atkinson, Paolo Pozzilli, Adina Zeidler, Leslie J Raffel, Chaim O Jacob, Yongsoo Park, Manuel Serrano-Rios, Maria T Martinez Larrad, Zixin Zhang, Henri-Jean Garchon, Jean-Francois Bach, Jerome I Rotter, Jin-Xiong She and Cong-Yi Wang Nature Genetics36, 837–841
(August 2004); doi:10.1038/ng1391
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article Allosteric inhibition of protein tyrosine phosphatase 1B
Christian Wiesmann, Kenneth J Barr, Jenny Kung, Jiang Zhu, Daniel A Erlanson, Wang Shen, Bruce J Fahr, Min Zhong, Lisa Taylor, Mike Randal, Robert S McDowell and Stig K Hansen Nature Structural and Molecular Biology11, 730–737
(August 2004); doi:10.1038/nsmb803
| Abstract | Full Text (HTML/PDF) |
review article Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle and Rudolf Kaaks Nature Reviews Cancer4, 579–591
(August 2004); doi:10.1038/nrc1408
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review article Lipid metabolic enzymes: emerging drug targets for the treatment of obesity
Yuguang Shi and Paul Burn Nature Reviews Drug Discovery3, 695–710
(August 2004); doi:10.1038/nrd1469
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news and views Type 1 diabetes: focus on prevention
Harald von Boehmer Nature Medicine10, 783–784
(August 2004); doi:10.1038/nm0804-783
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July
article Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
Min-Seon Kim, Joong-Yeol Park, Cherl Namkoong, Pil-Geum Jang, Je-Won Ryu, Hai-Sun Song, Ji-Young Yun, Il-Seong Namgoong, Joohun Ha, In-Sun Park, In-Kyu Lee, Benoit Viollet, Jang Hyun Youn, Hong-Kyu Lee and Ki-Up Lee Nature Medicine10, 727–733
(July 2004); doi:10.1038/nm1061
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news and views Cellular energy sensor balances the scales
Caroline J Small, David Carling and Stephen R Bloom Nature Medicine10, 681–682
(July 2004); doi:10.1038/nm0704-681
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letter A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone
Christine Dos Santos, Laurent Essioux, Cécile Teinturier, Maïté Tauber, Vincent Goffin and Pierre Bougnères Nature Genetics36, 720–724
(July 2004); doi:10.1038/ng1379
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letter Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
Jane K Howard, Belinda J Cave, Laura J Oksanen, Iphigenia Tzameli, Christian Bjørbæk and Jeffrey S Flier Nature Medicine10, 734–738
(July 2004); doi:10.1038/nm1072
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letter Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
Hiroyuki Mori, Reiko Hanada, Toshikatsu Hanada, Daisuke Aki, Ryuichi Mashima, Hitomi Nishinakamura, Takehiro Torisu, Kenneth R Chien, Hideo Yasukawa and Akihiko Yoshimura Nature Medicine10, 739–743
(July 2004); doi:10.1038/nm1071
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article GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation
Isao Usui, Takeshi Imamura, Hiroaki Satoh, Jie Huang, Jennie L Babendure, Christopher J Hupfeld and Jerrold M Olefsky The EMBO Journal23, 2821–2829
(July 2004); doi:10.1038/sj.emboj.7600297
| Abstract | Full Text (HTML/PDF) |
review article Insulin-like growth factors and neoplasia
Michael N. Pollak, Eva S. Schernhammer and Susan E. Hankinson Nature Reviews Cancer4, 505–518
(July 2004); doi:10.1038/nrc1387
| Abstract | Full Text (HTML / PDF) |
June
article Reversal of obesity by targeted ablation of adipose tissue
Mikhail G Kolonin, Pradip K Saha, Lawrence Chan, Renata Pasqualini and Wadih Arap Nature Medicine10, 625–632
(June 2004); doi:10.1038/nm1048
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news and views Magic bullets melt fat
Marc L Reitman Nature Medicine10, 581–582
(June 2004); doi:10.1038/nm0604-581
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letters to nature Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Frédéric Picard, Martin Kurtev, Namjin Chung, Acharawan Topark-Ngarm, Thanaset Senawong, Rita Machado de Oliveira, Mark Leid, Michael W. McBurney and Leonard Guarente Nature429, 771–776
(17 June 2004); doi:10.1038/nature02583
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letter Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
Xiao Yan Zhou, Nobuyuki Shibusawa, Karuna Naik, Delia Porras, Karla Temple, Hesheng Ou, Kelly Kaihara, Michael W Roe, Matthew J Brady and Fredric E Wondisford Nature Medicine10, 633–637
(June 2004); doi:10.1038/nm1050
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review article GSK3 inhibitors: development and therapeutic potential
Philip Cohen and Michel Goedert Nature Reviews Drug Discovery3, 479–487
(June 2004); doi:10.1038/nrd1415
| Abstract | Full Text (HTML / PDF) |
letters to nature Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
Dae Sung Hwangbo, Boris Gersham, Meng-Ping Tu, Michael Palmer and Marc Tatar Nature429, 562–566
(03 June 2004); doi:10.1038/nature02549
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May
article Adiponectin acts in the brain to decrease body weight
Yong Qi, Nobuhiko Takahashi, Stanley M Hileman, Hiralben R Patel, Anders H Berg, Utpal B Pajvani, Philipp E Scherer and Rexford S Ahima Nature Medicine10, 524–529
(May 2004); doi:10.1038/nm1029
| Abstract | Full Text (HTML/PDF) |
news and views Fat hormones pull their weight in the CNS
Randy J Seeley, David A D'Alessio and Stephen C Woods Nature Medicine10, 454–455
(May 2004); doi:10.1038/nm0504-454
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letter PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Seung-Hoi Koo, Hiroaki Satoh, Stephan Herzig, Chih-Hao Lee, Susan Hedrick, Rohit Kulkarni, Ronald M Evans, Jerrold Olefsky and Marc Montminy Nature Medicine10, 530–534
(May 2004); doi:10.1038/nm1044
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brief communication Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
Marco van den Top, Kevin Lee, Andrew D Whyment, Andrew M Blanks and David Spanswick Nature Neuroscience7, 493–494
(May 2004); doi:10.1038/nn1226
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letters to nature Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
Weihai He, Frederick J.-P. Miao, Daniel C.-H. Lin, Ralf T. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, Hui Tian and Lei Ling Nature429, 188–193
(13 May 2004); doi:10.1038/nature02488
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news and views Physiology: Orphan detectors of metabolism
Steven C. Hebert Nature429, 143–145
(13 May 2004); doi:10.1038/429143a
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article The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
Jun Chul Kim, Jose L Badano, Sonja Sibold, Muneer A Esmail, Josephine Hill, Bethan E Hoskins, Carmen C Leitch, Kerrie Venner, Stephen J Ansley, Alison J Ross, Michel R Leroux, Nicholas Katsanis and Philip L Beales Nature Genetics36, 462–470
(May 2004); doi:10.1038/ng1352
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news and views feature Ageing and the mystery at Arles
Shino Nemoto and Toren Finkel Nature429, 149–152
(13 May 2004); doi:10.1038/429149a
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article Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Yuval Dor, Juliana Brown, Olga I. Martinez and Douglas A. Melton Nature429, 41–46
(06 May 2004); doi:10.1038/nature02520
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news and views Regenerative medicine: Self-help for insulin cells
Ken Zaret Nature429, 30–31
(06 May 2004); doi:10.1038/429030a
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review article The weight of leptin in immunity
Antonio La Cava and Giuseppe Matarese Nature Reviews Immunology4, 371–379
(May 2004); doi:10.1038/nri1350
| Abstract | Full Text (HTML / PDF) |
April
brief communication A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini, Lucia Musumeci, Andres Alonso, Souad Rahmouni, Konstantina Nika, Masoud Rostamkhani, James MacMurray, Gian Franco Meloni, Paola Lucarelli, Maurizio Pellecchia, George S Eisenbarth, David Comings and Tomas Mustelin Nature Genetics36, 337–338
(April 2004); doi:10.1038/ng1323
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letter Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
Päivi Pajukanta, Heidi E Lilja, Janet S Sinsheimer, Rita M Cantor, Aldons J Lusis, Massimiliano Gentile, Xiaoqun Joyce Duan, Aino Soro-Paavonen, Jussi Naukkarinen, Janna Saarela, Markku Laakso, Christian Ehnholm, Marja-Riitta Taskinen and Leena Peltonen Nature Genetics36, 371–376
(April 2004); doi:10.1038/ng1320
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news and views USF1 on trial
Carol C Shoulders Nature Genetics36, 322–323
(April 2004); doi:10.1038/ng0404-322
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brief communication Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
Wei Fan, Kate L J Ellacott, Ilia G Halatchev, Kanji Takahashi, Pinxuan Yu and Roger D Cone Nature Neuroscience7, 335–336
(April 2004); doi:10.1038/nn1214
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review article Clinical islet transplantation: advances and immunological challenges
Camillo Ricordi and Terry B. Strom Nature Reviews Immunology4, 259–268
(April 2004); doi:10.1038/nri1332
| Abstract | Full Text (HTML / PDF) |
letters to nature AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Young-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J. Birnbaum, Bettina J. Stuck and Barbara B. Kahn Nature428, 569–574
(01 April 2004); doi:10.1038/nature02440
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letter SREBPs suppress IRS-2-mediated insulin signalling in the liver
Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi, Takashi Matsuzaka, Masanori Nakakuki, Takashi Yamamoto, Yoshimi Nakagawa, Akimitsu Takahashi, Hiroaki Suzuki, Hirohito Sone, Hideo Toyoshima, Akiyoshi Fukamizu and Nobuhiro Yamada Nature Cell Biology6, 351–357
(April 2004); doi:10.1038/ncb1111
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review article AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
Neil Ruderman and Marc Prentki Nature Reviews Drug Discovery3, 340–351
(April 2004); doi:10.1038/nrd1344
| Abstract | Full Text (HTML / PDF) |
March
article Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
Jie An, Deborah M Muoio, Masakazu Shiota, Yuka Fujimoto, Gary W Cline, Gerald I Shulman, Timothy R Koves, Robert Stevens, David Millington and Christopher B Newgard Nature Medicine10, 268–274
(March 2004); doi:10.1038/nm995
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letter A new cell-permeable peptide allows successful allogeneic islet transplantation in mice
Hirofumi Noguchi, Masayuki Matsushita, Teru Okitsu, Akiyoshi Moriwaki, Kazuhito Tomizawa, Sunghyun Kang, Sheng-Tian Li, Naoya Kobayashi, Shinichi Matsumoto, Koich Tanaka, Noriaki Tanaka and Hideki Matsui Nature Medicine10, 305–309
(March 2004); doi:10.1038/nm994
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article Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis
Klaus-Peter Knoch, Hendrik Bergert, Barbara Borgonovo, Hans-Detlev Saeger, Anke Altkrüger, Paul Verkade and Michele Solimena Nature Cell Biology6, 207–214
(March 2004); doi:10.1038/ncb1099
| Abstract | Full Text (HTML/PDF) |
news and views Fragile fugue: p53 in aging, cancer and IGF signaling
Judith Campisi Nature Medicine10, 231–232
(March 2004); doi:10.1038/nm0304-231
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February
article Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue, Kiyoshi Teshigawara, Shiyu Jin, Haruhisa Iguchi, Ryuji Hiramatsu, Derek LeRoith, Kiyoshi Takeda, Shizuo Akira and Masato Kasuga Nature Medicine10, 168–174
(February 2004); doi:10.1038/nm980
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news and views Inflamed about obesity
Michael Lehrke and Mitchell A Lazar Nature Medicine10, 126–127
(February 2004); doi:10.1038/nm0204-126
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January
letter Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
Angeles Almeida, Salvador Moncada and Juan P. Bolaños Nature Cell Biology6, 45–51
(January 2004); doi:10.1038/ncb1080
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news and views No glial death with NO
Solomon H. Snyder and Sangwon Kim Nature Cell Biology6, 17–18
(January 2004); doi:10.1038/ncb0104-17
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review article Tubby proteins: the plot thickens
Kilpatrick Carroll, Carlos Gomez and Lawrence Shapiro Nature Reviews Molecular Cell Biology5, 55–64
(January 2004); doi:10.1038/nrm1278
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