news and views Obesity: Aquaporin enters the picture
Gema Frühbeck Nature438, 436–437
(24 November 2005); doi:10.1038/438436b
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article Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
Margarete Mehrabian, Hooman Allayee, Jirina Stockton, Pek Yee Lum, Thomas A Drake, Lawrence W Castellani, Michael Suh, Christopher Armour, Stephen Edwards, John Lamb, Aldons J Lusis and Eric E Schadt Nature Genetics37, 1224–1233
(November 2005); doi:10.1038/ng1619
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October
article Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
Rei Shibata, Kaori Sato, David R Pimentel, Yukihiro Takemura, Shinji Kihara, Koji Ohashi, Tohru Funahashi, Noriyuki Ouchi and Kenneth Walsh Nature Medicine11, 1096–1103
(October 2005); doi:10.1038/nm1295
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news and views Fat, keeping the heart healthy?
Koh-ichi Yuhki, Jun-ichi Kawabe and Fumitaka Ushikubi Nature Medicine11, 1048–1049
(October 2005); doi:10.1038/nm1005-1048
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article Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems
Qi Wu, Zhangwu Zhao and Ping Shen Nature Neuroscience8, 1350–1355
(October 2005); doi:10.1038/nn1540
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article The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Seung-Hoi Koo, Lawrence Flechner, Ling Qi, Xinmin Zhang, Robert A. Screaton, Shawn Jeffries, Susan Hedrick, Wu Xu, Fayçal Boussouar, Paul Brindle, Hiroshi Takemori and Marc Montminy Nature437, 1109–11
(20 October 2005); doi:10.1038/nature03967
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research article A human β-cell line for transplantation therapy to control type 1 diabetes
Michiki Narushima, Naoya Kobayashi, Teru Okitsu, Yoshihito Tanaka, Shun-Ai Li, Yong Chen, Atsushi Miki, Kimiaki Tanaka, Shuhei Nakaji, Kohji Takei, Alejandro Soto Gutierrez, Jorge David Rivas-Carrillo, Nalu Navarro-Álvarez, Hee-Sook Jun, Karen A Westerman, Hirofumi Noguchi, Jonathan R T Lakey, Philippe Leboulch, Noriaki Tanaka and Ji-Won Yoon Nature Biotechnology23, 1274–1282
(October 2005); doi:10.1038/nbt1145
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news and views Islets for all?
Hans E Hohmeier and Christopher B Newgard Nature Biotechnology23, 1231–1232
(October 2005); doi:10.1038/nbt1005-1231
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letter Cdk5-dependent regulation of glucose-stimulated insulin secretion
Fan-Yan Wei, Kazuaki Nagashima, Toshio Ohshima, Yasunori Saheki, Yun-Fei Lu, Masayuki Matsushita, Yuichiro Yamada, Katsuhiko Mikoshiba, Yutaka Seino, Hideki Matsui and Kazuhito Tomizawa Nature Medicine11, 1104–1108
(October 2005); doi:10.1038/nm1299
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article Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
Natasha L Harvey, R Sathish Srinivasan, Miriam E Dillard, Nicole C Johnson, Marlys H Witte, Kelli Boyd, Mark W Sleeman and Guillermo Oliver Nature Genetics37, 1072–1081
(October 2005); doi:10.1038/ng1642
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news and views Lymph makes you fat
Martin Schneider, Edward M Conway and Peter Carmeliet Nature Genetics37, 1023–1024
(October 2005); doi:10.1038/ng1005-1023
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September
letter Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
Jin Zhang , Christopher J. Hupfeld, Susan S. Taylor, Jerrold M. Olefsky and Roger Y. Tsien Nature437, 569–573
(22 September 2005); doi:10.1038/nature04140
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August
article Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
YouFei Guan, Chuanming Hao, Dae Ryong Cha, Reena Rao, Wendell Lu, Donald E Kohan, Mark A Magnuson, Reyadh Redha, Yahua Zhang and Matthew D Breyer Nature Medicine11, 861–866
(August 2005); doi:10.1038/nm1278
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news and views TZDs and diabetes: testing the waters
Clay F Semenkovich Nature Medicine11, 822–824
(August 2005); doi:10.1038/nm0805-822
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July
article Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
Daniela Foti, Eusebio Chiefari, Monica Fedele, Rodolfo Iuliano, Leonardo Brunetti, Francesco Paonessa, Guidalberto Manfioletti, Fabrizio Barbetti, Arturo Brunetti, Carlo M Croce, Alfredo Fusco and Antonio Brunetti Nature Medicine11, 765–773
(July 2005); doi:10.1038/nm1254
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article Serum retinol binding protein
4 contributes to insulin resistance in obesity and type 2 diabetes Qin
Yang, Timothy E. Graham, Nimesh Mody, Frederic Preitner, Odile D. Peroni, Janice
M. Zabolotny, Ko Kotani, Loredana Quadro and Barbara B. Kahn Nature436, 356–362 (21 July 2005); doi:10.1038/nature03711 | Abstract | Full Text (HTML /
PDF) |
review article Ageing and metabolism: drug discovery opportunities
Rory Curtis, Bard J. Geesaman and Peter S. DiStefano Nature Reviews Drug Discovery AOP published online 24 June 2005; doi:10.1038/nrd1777
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May
letter Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
Emilie A Bard-Chapeau, Andrea L Hevener, Shinong Long, Eric E Zhang, Jerrold M Olefsky and Gen-Sheng Feng Nature Medicine11, 567–571
(May 2005); doi:10.1038/nm1227
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April
review article Calorie restriction, sirt1 and metabolism: understanding longevity
Laura Bordone and Leonard Guarente Nature Reviews Molecular Cell Biology6, 298–305
(April 2005); doi:10.1038/nrm1616
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review article The mitochondrial uncoupling-protein homologues
Stefan Krauss , Chen-Yu Zhang and Bradford B. Lowell Nature Reviews Molecular Cell Biology6, 248–261
(March 2005); doi:10.1038/nrm1592
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letters to nature Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Joseph T. Rodgers, Carlos Lerin, Wilhelm Haas, Steven P. Gygi, Bruce M. Spiegelman and Pere Puigserver Nature434, 113–118
(03 March 2005); doi:10.1038/nature03354
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February
article Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Dongsheng Cai, Minsheng Yuan, Daniel F Frantz, Peter A Melendez, Lone Hansen, Jongsoon Lee and Steven E Shoelson Nature Medicine11, 183–190
(February 2005); doi:10.1038/nm1166
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article IKK-β links inflammation to obesity-induced insulin resistance
Melek C Arkan, Andrea L Hevener, Florian R Greten, Shin Maeda, Zhi-Wei Li, Jeffrey M Long, Anthony Wynshaw-Boris, Giuseppe Poli, Jerrold Olefsky and Michael Karin Nature Medicine11, 191–198
(February 2005); doi:10.1038/nm1185
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article Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
Mark W Sleeman, Katherine E Wortley, Ka-Man V Lai, Lori C Gowen, Jennifer Kintner, William O Kline, Karen Garcia, Trevor N Stitt, George D Yancopoulos, Stanley J Wiegand and David J Glass Nature Medicine11, 199–205
(February 2005); doi:10.1038/nm1178
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news and views Staying in SHIP shape
Stuart J Decker and Alan R Saltiel Nature Medicine11, 123–124
(February 2005); doi:10.1038/nm0205-123
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article Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
Tohru Uchida, Takehiro Nakamura, Naoko Hashimoto, Tomokazu Matsuda, Ko Kotani, Hiroshi Sakaue, Yoshiaki Kido, Yoshitake Hayashi, Keiichi I Nakayama, Morris F White and Masato Kasuga Nature Medicine11, 175–182
(February 2005); doi:10.1038/nm1187
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January
letter Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Akira Hirasawa, Keiko Tsumaya, Takeo Awaji, Susumu Katsuma, Tetsuya Adachi, Masateru Yamada, Yukihiko Sugimoto, Shunichi Miyazaki and Gozoh Tsujimoto Nature Medicine11, 90–94
(January 2005); doi:10.1038/nm1168
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