letter Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
Markus Hafner, Anton Schmitz, Imke Grüne, Seergazhi G. Srivatsan, Bianca Paul, Waldemar Kolanus, Thomas Quast, Elisabeth Kremmer, Inga Bauer and Michael Famulok Nature444, 941–944
(14 December 2006); doi:10.1038/nature05415
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letter The cytohesin Steppke is essential for insulin signalling in Drosophila
Bernhard Fuss, Thomas Becker, Ingo Zinke and Michael Hoch Nature444, 945–948
(14 December 2006); doi:10.1038/nature05412
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review Adipocyte differentiation from the inside out
Evan D. Rosen and Ormond A. MacDougald Nature Reviews Molecular Cell Biology7, 885–896
(December 2006); doi:10.1038/nrm2066
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November
review The obesity pipeline: current strategies in the development of anti-obesity drugs
Dunstan Cooke and Steve Bloom Nature Revies Drug Discovery5, 919–931
(November 2006); doi:10.1038/nrd2159
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October
review Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Herbert Tilg and Alexander R. Moschen Nature Reviews Immunology6, 772–783
(October 2006); doi:10.1038/nri1937
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September
letter Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function
Jeremy J. Heit, Åsa A. Apelqvist, Xueying Gu, Monte M. Winslow, Joel R. Neilson, Gerald R. Crabtree and Seung K. Kim Nature443, 345–349
(21 September 2006); doi:10.1038/nature05097
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article NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz Nature Medicine12, 1048–1055
(2006); doi:10.1038/nm1471
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letter Structure of the insulin receptor ectodomain reveals a folded-over conformation
Neil M. McKern, Michael C. Lawrence, Victor A. Streltsov, Mei-Zhen Lou, Timothy E. Adams, George O. Lovrecz, Thomas C. Elleman, Kim M. Richards, John D. Bentley, Patricia A. Pilling, Peter A. Hoyne, Kellie A. Cartledge, Tam M. Pham, Jennifer L. Lewis, Sonia E. Sankovich, Violet Stoichevska, Elizabeth Da Silva, Christine P. Robinson, Maurice J. Frenkel, Lindsay G. Sparrow, Ross T. Fernley, V. Chandana Epa and Colin W. Ward Nature443, 218–221
(14 September 2006); doi:10.1038/nature05106
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July
article Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Min-Seon Kim, Youngmi K Pak, Pil-Geum Jang, Cherl Namkoong, Yon-Sik Choi, Jong-Chul Won, Kyung-Sup Kim, Seung-Whan Kim, Hyo-Soo Kim, Joong-Yeol Park, Young-Bum Kim, Ki-Up Lee Nature Neuroscience49, 901–906
(July 2006); doi:10.1038/nn1731
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June
article Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
Mihai G Netea, Leo A B Joosten, Eli Lewis, Dalan R Jensen, Peter J Voshol, Bart Jan Kullberg, Cees J Tack, Han van Krieken, Soo-Hyun Kim, Anton F Stalenhoef, Fons A van de Loo, Ineke Verschueren, Leslie Pulawa, Shizuo Akira, Robert H Eckel, Charles A Dinarello, Wim van den Berg & Jos W M van der Meer Nature Medicine12, 650 - 656
(June 2006); doi:10.1038/nm1415
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article Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
Valérie Senée, Claude Chelala, Sabine Duchatelet, Daorong Feng, Hervé Blanc, Jack-Christophe Cossec, Céline Charon, Marc Nicolino, Pascal Boileau, Douglas R Cavener, Pierre Bougnères, Doris Taha & Cécile Julier Nature Genetics38, 682 - 687
(June 2006); doi:10.1038/ng1802
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May
article The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis
Marie-Julie Dubois, Sébastien Bergeron, Hyo-Jeong Kim, Luce Dombrowski, Mylène Perreault, Bénédicte Fournès, Robert Faure, Martin Olivier, Nicole Beauchemin, Gerald I Shulman, Katherine A Siminovitch, Jason K Kim & André Marette Nature Medicine12, 549–556
(May 2006); doi:10.1038/nm1397
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article Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5
Hassan Mziaut, Mirko Trajkovski, Stephan Kersting, Armin Ehninger, Anke Altkrüger, Régis P. Lemaitre, Darja Schmidt, Hans–Detlev Saeger, Myung–Shik Lee, David N. Drechsel, Stefan Müller & Michele Solimena Nature Cell Biology8, 435 –445
(May 2006); doi:10.1038/ncb1395
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article Forkhead protein FoxO1 mediates Agrp–dependent effects of leptin on food intake
Tadahiro Kitamura, Yun Feng, Yukari Ido Kitamura, Streamson C Chua, Allison W Xu, Gregory S Barsh, Luciano Rossetti, Domenico Accili Nature Medicine12, 534–540
(May 2006); doi:10.1038/nm1392
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letter Total insulin and IGF–I resistance in pancreatic β cells causes overt diabetes
Kohjiro Ueki, Terumasa Okada, Jiang Hu, Chong Wee Liew, Anke Assmann, Gabriella M Dahlgren, Jennifer L Peters, Jonathan G Shackman, Min Zhang, Isabella Artner, Leslie S Satin, Roland Stein, Martin Holzenberger, Robert T Kennedy, C Ronald Kahn & Rohit N Kulkarni Nature Genetics38, 583–588
(May 2006); doi:10.1038/ng1787
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letter Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass
Naoko Hashimoto, Yoshiaki Kido, Tohru Uchida, Shun-ichiro Asahara, Yutaka Shigeyama, Tomokazu Matsuda, Akihiko Takeda, Daisuke Tsuchihashi, Akihiko Nishizawa, Wataru Ogawa, Yoshito Fujimoto, Hitoshi Okamura, Karen C Arden, Pedro L Herrera, Tetsuo Noda & Masato Kasuga Nature Genetics38, 589–593
(May 2006); doi:10.1038/ng1774
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article CNTF reverses obesity–induced insulin resistance by activating skeletal muscle AMPK
Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose–John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio & Gregory R Steinberg Nature Medicine12, 541–548
(May 2006); doi:10.1038/nm1383
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news and views Overcoming insulin resistance with CNTF
Rexford S Ahima Nature Medicine12, 511–512
(May 2006); doi:10.1038/nm0506–511
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letter APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
Xuming Mao, Chintan K. Kikani, Ramon A. Riojas, Paul Langlais, Lixin Wang, Fresnida J. Ramos, Qichen Fang, Christine Y. Christ-Roberts, Jenny Y. Hong, Ryang-Yeo Kim, Feng Liu & Lily Q. Dong Nature Cell Biology8, 516–523
(May 2006) | doi:10.1038/ncb1404
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April
article Induction of leptin resistance through direct interaction of C-reactive protein with leptin
Ke Chen, Fanghong Li, Ji Li, Hongbo Cai, Steven Strom, Alessandro Bisello, David E Kelley, Miriam Friedman-Einat, Gregory A Skibinski, Mark A McCrory, Alexander J Szalai & Allan Z Zhao Nature Medicine12, 425–432
(April 2006); doi:10.1038/nm1372
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letter Reactive oxygen species have a causal role in multiple forms of insulin resistance
Nicholas Houstis , Evan D. Rosen and Eric S. Lander Nature440, 944–948
(13 April 2006); doi:10.1038/nature04634
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article Lipid phosphatases as drug discovery targets for type 2 diabetes
Dan F. Lazar and Alan R. Saltiel Nature Reviews Drug Discovery5, 333–342
(April 2006); doi:10.1038/nrd2007
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March
letter Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong & Kari Stefansson Nature Genetics38, 320–323
(March 2006); doi:10.1038/ng1732
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February
review article Critical nodes in signalling pathways: insights into insulin action
Cullen M. Taniguchi , Brice Emanuelli and C. Ronald Kahn Nature Reviews Molecular Cell Biology7, 85–96
(February 2006); doi:10.1038/nrm1837
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