Research library: Diabetes / Obesity

2007: December | November | October | September | August | July | June | April | March | February | January

Other Years: 2002 | 2003 | 2004 | 2005 | 2006

December

scientific report
Tripeptidyl peptidase II promotes fat formation in a conserved fashion
Renée M McKay, James P McKay, Jae Myoung Suh, Leon Avery & Jonathan M Graff
EMBO Reports 8, 1183–1189
(December 2007); doi:10.1038/sj.embor.7401086
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November

letter
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
Nature 450, 712–716
(29 November 2007); doi:10.1038/nature06261
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review
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Nicholas A. Bishop & Leonard Guarente
Nature Reviews Genetics 8, 835–844
(November 2007); doi:10.1038/nrg2188
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article
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1
Heiko Johnen et al.
Nature Medicine 13, 1333–1340
(November 2007); doi:10.1038/nm1677
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October

article
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Toyonori Kato, Ayaka Atsumi, Takashi Yamamoto, Noriyuki Inoue, Mayumi Ishikawa, Sumiyo Okada, Naomi Ishigaki, Hitoshi Iwasaki, Yuko Iwasaki, Tadayoshi Karasawa, Shin Kumadaki, Toshiyuki Matsui, Motohiro Sekiya, Ken Ohashi, Alyssa H Hasty, Yoshimi Nakagawa, Akimitsu Takahashi, Hiroaki Suzuki, Sigeru Yatoh, Hirohito Sone, Hideo Toyoshima, Jun-ichi Osuga & Nobuhiro Yamada
Nature Medicine 13, 1193–1202
(October 2007); doi:10.1038/nm1662
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news and views
It's what you do with the fat that matters!
Clinton R Bruce & Mark A Febbraio
Nature Medicine 13, 1137–1138
(October 2007); doi:10.1038/nm1007-1137
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review
RAR and RXR modulation in cancer and metabolic disease
Lucia Altucci, Mark D. Leibowitz, Kathleen M. Ogilvie, Angel R. de Lera & Hinrich Gronemeyer
Nature Reviews Drug Discovery 6, 793–810
(October 2007); doi:10.1038/nrd2397
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review
Design of selective nuclear receptor modulators: RAR and RXR as a case study
Angel R. de Lera, William Bourguet, Lucia Altucci & Hinrich Gronemeyer
Nature Reviews Drug Discovery 6, 811–820
(October 2007); doi:10.1038/nrd2398
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September

letter
Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
Gabriele A. Amodeo, Michael J. Rudolph & Liang Tong
Nature 449, 492–495
(27 September 2007); doi:10.1038/nature06127
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letter
Structural basis for AMP binding to mammalian AMP-activated protein kinase
Bing Xiao, Richard Heath, Peter Saiu, Fiona C. Leiper, Philippe Leone, Chun Jing, Philip A. Walker, Lesley Haire, John F. Eccleston, Colin T. Davis, Stephen R. Martin, David Carling & Steven J. Gamblin
Nature 449, 496–500
(27 September 2007); doi:10.1038/nature06161
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article
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Christopher E Lowe, Jason D Cooper, Todd Brusko, Neil M Walker, Deborah J Smyth, Rebecca Bailey, Kirsi Bourget, Vincent Plagnol, Sarah Field, Mark Atkinson, David G Clayton, Linda S Wicker & John A Todd
Nature Genetics 39, 1074–1082
(September 2007); doi:10.1038/ng2102
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letter
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
Renaud Dentin, Yi Liu, Seung-Hoi Koo, Susan Hedrick, Thomas Vargas, Jose Heredia, John Yates, III & Marc Montminy
Nature 449, 366–369
(20 September 2007); doi:10.1038/nature06128
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letter
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Laura E. Parton, Chian Ping Ye, Roberto Coppari, Pablo J. Enriori, Brian Choi, Chen-Yu Zhang, Chun Xu, Claudia R. Vianna, Nina Balthasar, Charlotte E. Lee, Joel K. Elmquist, Michael A. Cowley & Bradford B. Lowell
Nature 449, 228–232
(13 September 2007); doi:10.1038/nature06098
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August

letter
Cathepsin L activity controls adipogenesis and glucose tolerance
Min Yang, Yaou Zhang, Jiehong Pan, Jiusong Sun, Jian Liu, Peter Libby, Galina K. Sukhova, Alessandro Doria, Nobuhiko Katunuma, Odile D. Peroni, Michèle Guerre-Millo, Barbara B. Kahn, Karine Clement & Guo-Ping Shi
Nature Cell Biology 9, 978–981
(August 2007); doi:10.1038/ncb1623
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article
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
Charles W Pemble IV, Lynnette C Johnson, Steven J Kridel & W Todd Lowther
Nature Structural & Molecular Biology 14, 704–709
(August 2007); doi:10.1038/nsmb1265
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July

article
Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome
Lydia E Kuo, Joanna B Kitlinska, Jason U Tilan, Lijun Li, Stephen B Baker, Michael D Johnson, Edward W Lee, Mary Susan Burnett, Stanley T Fricke, Richard Kvetnansky, Herbert Herzog & Zofia Zukowska
Nature Medicine 13, 803–811
(July 2007); doi:10.1038/nm1611
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correspondence
Stress, diet and abdominal obesity: Y?
James P Warne & Mary F Dallman
Nature Medicine 13, 781–783
(July 2007); doi:10.1038/nm0707-781
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letter
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
John A Todd et al.
Nature Genetics 39, 857–864
(July 2007); doi:10.1038/ng2068
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news and views
Guilt beyond a reasonable doubt
David Altshuler & Mark Daly
Nature Genetics 39, 813–815
(July 2007); doi:10.1038/ng0707-813
| Summary | Full Text (HTML / PDF) |

June

letter
Macrophage-specific PPAR γ controls alternative activation and improves insulin resistance
Justin I. Odegaard, Roberto R. Ricardo-Gonzalez, Matthew H. Goforth, Christine R. Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W. Ferrante & Ajay Chawla
Nature 447, 1116–1120
(28 June 2007); doi:10.1038/nature05894
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article
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
Masato Furuhashi, Gürol Tuncman, Cem Z. Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R. Babaev, Sergio Fazio, MacRae F. Linton, Richard Sulsky, Jeffrey A. Robl, Rex A. Parker & Gökhan S. Hotamisligil
Nature 447, 959–965
(21 June 2007); doi:10.1038/nature05844
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article
Retinaldehyde represses adipogenesis and diet-induced obesity
Ouliana Ziouzenkova, Gabriela Orasanu, Molly Sharlach, Taro E Akiyama, Joel P Berger, Jason Viereck, James A Hamilton, Guangwen Tang, Gregory G Dolnikowski, Silke Vogel, Gregg Duester & Jorge Plutzky
Nature Medicine 13, 695–702
(June 2007); doi:10.1038/nm1587
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news and views
Retinaldehyde: more than meets the eye
Béatrice Desvergne
Nature Medicine 13, 671–673
(June 2007); doi:10.1038/nm0607-671
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article
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium
Nature 447, 661–678
(7 June 2007); doi:10.1038/nature05911
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news and views
Genomics: Guilt by association
Anne M. Bowcock
Nature 447, 645–646
(7 June 2007); doi:10.1038/447645a
| Full Text (HTML / PDF) |

April

article
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
Lisa A Lesniewski, Sarah E Hosch, Jaap G Neels, Carl de Luca, Mohammad Pashmforoush, Carey N Lumeng, Shian-Huey Chiang, Miriam Scadeng, Alan R Saltiel & Jerrold M Olefsky
Nature Medicine 13, 455–462
(April 2007); doi:10.1038/nm1550
| Summary | Full Text (HTML / PDF) |

March

article
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, Masaki Kobayashi, Takeshi Takazawa, Masato Iwabu, Miki Okada-Iwabu, Sachiko Kawamoto, Naoto Kubota, Tetsuya Kubota, Yusuke Ito, Junji Kamon, Atsushi Tsuchida, Katsuyoshi Kumagai, Hideki Kozono, Yusuke Hada, Hitomi Ogata, Kumpei Tokuyama, Masaki Tsunoda, Tomohiro Ide, Kouji Murakami, Motoharu Awazawa, Iseki Takamoto, Philippe Froguel, Kazuo Hara, Kazuyuki Tobe, Ryozo Nagai, Kohjiro Ueki & Takashi Kadowaki
Nature Medicine 13, 332–339
(March 2007); doi:10.1038/nm1557
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article
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment pp340
Liam R Brunham, Janine K Kruit, Terry D Pape, Jenelle M Timmins, Anne Q Reuwer, Zainisha Vasanji, Brad J Marsh, Brian Rodrigues, James D Johnson, John S Parks, C Bruce Verchere & Michael R Hayden
Nature Medicine 13, 340–347
(March 2007); doi:10.1038/nm1546
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February

article
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, David Meyre, Constantin Polychronakos and Philippe Froguel
Nature 445, 881–885
(22 February 2007); doi:10.1038/nature05616
| Summary | Full Text (HTML / PDF) |

January

letter
The nuclear receptor LXR is a glucose sensor
Nico Mitro, Puiying A. Mak, Leo Vargas, Cristina Godio, Eric Hampton, Valentina Molteni, Andreas Kreusch and Enrique Saez
Nature 445, 219–223
(11 January 2007); doi:10.1038/nature05449
| First Paragraph | Full Text (HTML / PDF) |

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