Research library: Differentiation
2004: December
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December
letters to nature
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
Antonio Iavarone , Emerson R. King, Xu-Ming Dai, Gustavo Leone, E. Richard Stanley and Anna Lasorella
Nature 432, 1040–1045
(23 December 2004); doi:10.1038/nature03068
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news and views
Developmental biology: No red cell is an island
James Palis
Nature 432, 964–965
(23 December 2004); doi:10.1038/432964a
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article
Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection
Elina I Zuniga, Dorian B McGavern, Jose L Pruneda-Paz, Chao Teng and Michael B A Oldstone
Nature Immunology 5, 1227–1234
(December 2004); doi:10.1038/ni1136
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news and views
Are dendritic cells afraid of commitment?
Anne O'Garra and Giorgio Trinchieri
Nature Immunology 5, 1206–1208
(December 2004); doi:10.1038/ni1204-1206
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news and views
PINOID pinpoints auxin
Myrto Raftopoulou
Nature Cell Biology 6, 1149
(December 2004); doi:10.1038/ncb1204-1149
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article
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
K Mark Ansel, Rebecca J Greenwald, Suneet Agarwal, Craig H Bassing, Silvia Monticelli, Jeneen Interlandi, Ivana M Djuretic, Dong U Lee, Arlene H Sharpe, Frederick W Alt and Anjana Rao
Nature Immunology 5, 1251–1259
(December 2004); doi:10.1038/ni1135
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article
Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
Alfonso Martín-Fontecha, Lindy L Thomsen, Sara Brett, Craig Gerard, Martin Lipp, Antonio Lanzavecchia and Federica Sallusto
Nature Immunology 5, 1260–1265
(December 2004); doi:10.1038/ni1138
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November
news and views
Are dendritic cells end cells?
Ken Shortman and Li Wu
Nature Immunology 5, 1105–1106
(November 2004); doi:10.1038/ni1104-1105
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article
Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells
Minghui Zhang, Hua Tang, Zhenhong Guo, Huazhang An, Xuejun Zhu, Wengang Song, Jun Guo, Xin Huang, Taoyong Chen, Jianli Wang and Xuetao Cao
Nature Immunology 5, 1124–1133
(November 2004); doi:10.1038/ni1130
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article
Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses
Jinfang Zhu, Booki Min, Jane Hu-Li, Cynthia J Watson, Alex Grinberg, Qi Wang, Nigel Killeen, Joseph F Urban, Jr Liying Guo and William E Paul
Nature Immunology 5, 1157–1165
(November 2004); doi:10.1038/ni1128
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October
letters to nature
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Catherine M. Shachaf, Andrew M. Kopelman, Constadina Arvanitis, Åsa Karlsson, Shelly Beer, Stefanie Mandl, Michael H. Bachmann, Alexander D. Borowsky, Boris Ruebner, Robert D. Cardiff, Qiwei Yang, J. Michael Bishop, Christopher H. Contag and Dean W. Felsher
Nature 431, 1112–1117
(28 October 2004); doi:10.1038/nature03043
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letter
DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei
Stina Simonsson and John Gurdon
Nature Cell Biology 6, 984–990
(October 2004); doi:10.1038/ncb1176
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news and views
Nuclear transfer: Epigenetics pays a visit
Naoyuki Fujita and Paul A. Wade
Nature Cell Biology 6, 920–922
(October 2004); doi:10.1038/ncb1004-920
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letters to nature
Migratory neural crest-like cells form body pigmentation in a urochordate embryo
William R. Jeffery, Allen G. Strickler and Yoshiyuki Yamamoto
Nature 431, 696–699
(07 October 2004); doi:10.1038/nature02975
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article
GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
Hai-Hui Xue, Julie Bollenbacher, Valentina Rovella, Radhika Tripuraneni, Yu-Bin Du, Cheng-Yu Liu, Ann Williams, J Philip McCoy and Warren J Leonard
Nature Immunology 5, 1036–1044
(October 2004); doi:10.1038/ni1117
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review article
A stepwise epigenetic process controls immunoglobulin allelic exclusion
Yehudit Bergman and Howard Cedar
Nature Reviews Immunology 4, 753–761
(October 2004); doi:10.1038/nri1458
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article
A role for the immunological synapse in lineage commitment of CD4 lymphocytes
Roberto A. Maldonado, Darrell J. Irvine, Robert Schreiber and Laurie H. Glimcher
Nature 431, 527–532
(30 September 2004); doi:10.1038/nature02916
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September
letters to nature
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
Lina Kassar-Duchossoy, Barbara Gayraud-Morel, Danielle Gomès, Didier Rocancourt, Margaret Buckingham, Vasily Shinin and Shahragim Tajbakhsh
Nature 431, 466–471
(23 September 2004); doi:10.1038/nature02876
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news and views
Stretching cell fate
Donald McDonald
Nature Cell Biology 6, 803
(September 2004); doi:10.1038/ncb0904-803
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letter
Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
Lolitika Mandal, Utpal Banerjee and Volker Hartenstein
Nature Genetics 36, 1019–1023
(September 2004); doi:10.1038/ng1404
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letters to nature
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C
Georgia Gliki, Klaus Ebnet, Michel Aurrand-Lions, Beat A. Imhof and Ralf H. Adams
Nature 431, 320–324
(16 September 2004); doi:10.1038/nature02877
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July
research article
A role for chemistry in stem cell biology
Sheng Ding and Peter G Schultz
Nature Biotechnology 22, 833–840
(July 2004); doi:10.1038/nbt987
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letters to nature
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation
Edward H. Liao, Wesley Hung, Benjamin Abrams and Mei Zhen
Nature 430, 345–350
(15 July 2004); doi:10.1038/nature02647
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letters to nature
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage
Andrew E. Wurmser, Kinichi Nakashima, Robert G. Summers, Nicolas Toni, Kevin A. D'Amour, Dieter C. Lie and Fred H. Gage
Nature 430, 350–356
(15 July 2004); doi:10.1038/nature02604
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article
Critical functions for c-Myb at three checkpoints during thymocyte development
Timothy P Bender, Christopher S Kremer, Manfred Kraus, Thorsten Buch and Klaus Rajewsky
Nature Immunology 5, 721–729
(July 2004); doi:10.1038/ni1085
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letter
p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
Cristiano Simone, Sonia Vanina Forcales, David A Hill, Anthony N Imbalzano, Lucia Latella and Pier Lorenzo Puri
Nature Genetics 36, 738–743
(July 2004); doi:10.1038/ng1378
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news and views
Something to SNF about
Mark A Gillespie and Michael A Rudnicki
Nature Genetics 36, 676–677
(July 2004); doi:10.1038/ng0704-676
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review article
One tissue, two fates: molecular genetic events that underlie testis versus ovary development
Jennifer Brennan and Blanche Capel
Nature Reviews Genetics 5, 509–521
(July 2004); doi:10.1038/nrg1381
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review article
CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals
Rémy Bosselut
Nature Reviews Immunology 4, 529–540
(July 2004); doi:10.1038/nri1392
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June
letter
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
Sachiko Kamakura, Koji Oishi, Takeshi Yoshimatsu, Masato Nakafuku, Norihisa Masuyama and Yukiko Gotoh
Nature Cell Biology 6, 547–554
(June 2004); doi:10.1038/ncb1138
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article
Ascl1/Mash1 is required for the development of central serotonergic neurons
Alexandre Pattyn, Nicolas Simplicio, J Hikke van Doorninck, Christo Goridis, François Guillemot and Jean-François Brunet
Nature Neuroscience 7, 589–595
(June 2004); doi:10.1038/nn1247
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article
Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells
Tetsuya Yamagata, Diane Mathis and Christophe Benoist
Nature Immunology 5, 597–605
(June 2004); doi:10.1038/ni1070
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news and views
Nondeletional pathways for the development of autoreactive thymocytes
Albert Bendelac
Nature Immunology 5, 557–558
(June 2004); doi:10.1038/ni0604-557
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research article
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
Ralph Brandenberger, Henry Wei, Sally Zhang, Shirley Lei, Jaji Murage, Gregory J Fisk, Yan Li, Chunhui Xu, Rixun Fang, Karl Guegler, Mahendra S Rao, Ramumkar Mandalam, Jane Lebkowski and Lawrence W Stanton
Nature Biotechnology 22, 707–716
(June 2004); doi:10.1038/nbt971
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letters to nature
The transcriptional programme of antibody class switching involves the repressor Bach2
Akihiko Muto, Satoshi Tashiro, Osamu Nakajima, Hideto Hoshino, Satoru Takahashi, Eiichirou Eakoda, Dai Ikebe, Masayuki Yamamoto & Kazuhiko Igarashi
Nature 429, 566–571
(03 June 2004); doi:10.1038/nature02596
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May
news and views
Tlx genes make an exciting choice
Stewart Anderson
Nature Neuroscience 7, 421–422
(May 2004); doi:10.1038/nn0504-421
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article
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Leping Cheng, Akiko Arata, Rumiko Mizuguchi, Ying Qian, Asanka Karunaratne, Paul A Gray, Satoru Arata, Senji Shirasawa, Maxime Bouchard, Ping Luo, Chih-Li Chen, Meinrad Busslinger, Martyn Goulding, Hiroshi Onimaru and Qiufu Ma
Nature Neuroscience 7, 510–517
(May 2004); doi:10.1038/nn1221
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article
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Yuval Dor, Juliana Brown, Olga I. Martinez and Douglas A. Melton
Nature 429, 41–46
(06 May 2004); doi:10.1038/nature02520
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news and views
Regenerative medicine: Self-help for insulin cells
Ken Zaret
Nature 429, 30–31
(06 May 2004); doi:10.1038/429030a
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news and views
Actin dynamics: re-drawing the map
Phillip R. Gordon-Weeks
Nature Cell Biology 6, 390–391
(May 2004); doi:10.1038/ncb0504-390
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April
article
Continued maturation of thymic emigrants in the periphery
Tamar E Boursalian, Jonathan Golob, David M Soper, Cristine J Cooper and Pamela J Fink
Nature Immunology 5, 418–425
(April 2004); doi:10.1038/ni1049
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article
Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
Pietro G Andres, Kimberly C Howland, Ajay Nirula, Lawrence P Kane, Luke Barron, Douglas Dresnek, Ali Sadra, John Imboden, Arthur Weiss and Abul K Abbas
Nature Immunology 5, 435–442
(April 2004); doi:10.1038/ni1044
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article
Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
Norihiko Watanabe, Shino Hanabuchi, Vassili Soumelis, Wei Yuan, Stephen Ho, Rene de Waal Malefyt and Yong-Jun Liu
Nature Immunology 5, 426–434
(April 2004); doi:10.1038/ni1048
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letters to nature
Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries
Toshie Kai and Allan Spradling
Nature 428, 564–569
(01 April 2004); doi:10.1038/nature02436
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article
Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro
Thomas M Schmitt, Renée F de Pooter, Matthew A Gronski, Sarah K Cho, Pamela S Ohashi and Juan Carlos Zúñiga-Pflücker
Nature Immunology 5, 410–417
(April 2004); doi:10.1038/ni1055
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news and views
From totipotency to T in a dish
Ellen V Rothenberg
Nature Immunology 5, 359–360
(April 2004); doi:10.1038/ni0404-359
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March
article
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
Patrick S Costello, Robert H Nicolas, Yasuyuki Watanabe, Ian Rosewell and Richard Treisman
Nature Immunology 5, 289–298
(March 2004); doi:10.1038/ni1038
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article
PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing
Ildikó Gyõry, Jian Wu, György Fejér, Edward Seto and Kenneth L Wright
Nature Immunology 5, 299–308
(March 2004); doi:10.1038/ni1046
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news and views
Sounds of a silent Blimp-1
Karen W Makar and Christopher B Wilson
Nature Immunology 5, 241–242
(March 2004); doi:10.1038/ni0304-241
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article
B cell receptor signal strength determines B cell fate
Stefano Casola, Kevin L Otipoby, Marat Alimzhanov, Sibille Humme, Nathalie Uyttersprot, Jeffery L Kutok, Michael C Carroll and Klaus Rajewsky
Nature Immunology 5, 317–327
(March 2004); doi:10.1038/ni1036
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review article
Notch regulation of lymphocyte development and function
Freddy Radtke, Anne Wilson, Stephane J C Mancini and H Robson MacDonald
Nature Immunology 5, 247–253
(March 2004); doi:10.1038/ni1045
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letter
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
Motoshi Ichikawa, Takashi Asai, Toshiki Saito, Go Yamamoto, Sachiko Seo, Ieharu Yamazaki, Tetsuya Yamagata, Kinuko Mitani, Shigeru Chiba, Hisamaru Hirai, Seishi Ogawa and Mineo Kurokawa
Nature Medicine 10, 299–304
(March 2004); doi:10.1038/nm997
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news and views
AML-1 steps up to the platelets
Brenda J Irvin and Scott W Hiebert
Nature Medicine 10, 238–239
(March 2004); doi:10.1038/nm0304-238
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letter
Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation
Kimberly Stegmaier, Kenneth N Ross, Sierra A Colavito, Shawn O'Malley, Brent R Stockwell and Todd R Golub
Nature Genetics 36, 257–263
(March 2004); doi:10.1038/ng1305
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news and views
Gene expression as a drug discovery tool
William E Evans and R Kip Guy
Nature Genetics 36, 214–215
(March 2004); doi:10.1038/ng0304-214
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letter
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
Gijs R van den Brink, Sylvia A Bleuming, James C H Hardwick, Berber L Schepman, G Johan Offerhaus, Josbert J Keller, Corinne Nielsen, William Gaffield, Sander J H van Deventer, Drucilla J Roberts & Maikel P Peppelenbosch
Nature Genetics 36, 277–282
(March 2004); doi:10.1038/ng1304
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article
Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
Xiaolong Liu and Rémy Bosselut
Nature Immunology 5, 280–288
(March 2004); doi:10.1038/ni1040
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review article
Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
Eric Vivier and Nicolas Anfossi
Nature Reviews Immunology 4, 190–198
(March 2004); doi:10.1038/nri1306
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article
FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation
Mi-Ryoung Song and Anirvan Ghosh
Nature Neuroscience 7, 229–235
(March 2004); doi:10.1038/nn1192
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February
January
article
fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo
Julien Dubrulle and Olivier Pourquié
Nature 427, 419–422
(29 January 2004); doi:10.1038/nature02216
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news and views
Developmental biology: Tail of decay
Alexander F. Schier
Nature 427, 403–404
(29 January 2004); doi:10.1038/427403a
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letter
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
Ryo Sumazaki, Nobuyoshi Shiojiri, Shigemi Isoyama, Masayuki Masu, Kazuko Keino-Masu, Mitsujiro Osawa, Hiromitsu Nakauchi, Ryoichiro Kageyama and Akira Matsui
Nature Genetics 36, 83–87
(January 2004); doi:10.1038/ng1273
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article
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Noboru Sato, Laurent Meijer, Leandros Skaltsounis, Paul Greengard and Ali H Brivanlou
Nature Medicine 10, 55–63
(January 2004); doi:10.1038/nm979
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news and views
Embryonic stem cells: staying plastic on plastic
Kinichi Nakashima, Sophia Colamarino and Fred H Gage
Nature Medicine 10, 23–24
(January 2004); doi:10.1038/nm0104-23
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perspectives
Innovation: T-cell development made simple
Juan Carlos Zúñiga-Pflücker
Nature Reviews Immunology 4, 67–72
(January 2004); doi:10.1038/nri1257
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article
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
Scott T Avecilla, Koichi Hattori, Beate Heissig, Rafael Tejada, Fang Liao, Koji Shido, David K Jin, Sergio Dias, Fan Zhang, Travis E Hartman, Neil R Hackett, Ronald G Crystal, Larry Witte, Daniel J. Hicklin, Peter Bohlen, Dan Eaton, David Lyden, Fredric de Sauvage and Shahin Rafii
Nature Medicine 10, 64–71
(January 2004); doi:10.1038/nm973
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letter
The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling
Sarah Baxendale, Claire Davison, Claire Muxworthy, Christian Wolff, Philip W Ingham and Sudipto Roy
Nature Genetics 36, 88–93
(January 2004); doi:10.1038/ng1280
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news and views
White meat or dark?
Ava E Brent and Clifford J Tabin
Nature Genetics 36, 8–10
(January 2004); doi:10.1038/ng0104-8
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