article
HIV-specific CD8⁺ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
Stephen A. Migueles, Alisha C. Laborico, W. Lesley Shupert, M. Shirin Sabbaghian, Ronald Rabin, Claire W. Hallahan, Debbie Van Baarle, Stefan Kostense, Frank Miedema, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu and Mark Connors
Nature Immunology 3, 1061–1068
(November 2002); doi:10.1038/ni845
| Abstract | Full Text (HTML/PDF) |

review article
Natural selection of tumor variants in the generation of “tumor escape” phenotypes
Hung T. Khong and Nicholas P. Restifo
Nature Immunology 3, 999–1005
(November 2002); doi:10.1038/ni1102-999
| Abstract | Full Text (HTML/PDF) |

review article
Viral interference with antigen presentation
Jonathan W. Yewdell and Ann B. Hill
Nature Immunology 3, 1019–1025
(November 2002); doi:10.1038/ni1102-1019
| Abstract | Full Text (HTML/PDF) |

review article
Bacterial strategies for overcoming host innate and adaptive immune responses
Mathias W. Hornef, Mary Jo Wick, Mikael Rhen and Staffan Normark
Nature Immunology 3, 1033–1040
(November 2002); doi:10.1038/ni1102-1033
| Abstract | Full Text (HTML/PDF) |

review article
Hepatitis C therapeutics: current status and emerging strategies
Seng-Lai Tan, Arnim Pause, Yuguang Shi and Nahum Sonenberg
Nature Reviews Drug Discovery 1, 867–881
(November 2002); doi:10.1038/nrd937
| Summary | Full Text (HTML / PDF) |

letters to nature
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Hideki Sanjo, Satoshi Uematsu, Tsuneyasu Kaisho , Katsuaki Hoshino, Osamu Takeuchi, Masaya Kobayashi, Takashi Fujita, Kiyoshi Takeda and Shizuo Akira
Nature 420, 324–329
(21 November 2002); doi:10.1038/nature01182
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
Tiffany Horng, Gregory M. Barton, Richard A. Flavell and Ruslan Medzhitov
Nature 420, 329–333
(21 November 2002); doi:10.1038/nature01180
| First Paragraph | Full Text (HTML / PDF) |

article
Thymocyte expression of cathepsin L is essential for NKT cell development
Karen Honey, Kamel Benlagha, Courtney Beers, Katherine Forbush, Luc Teyton, Monique J. Kleijmeer, Alexander Y. Rudensky and Albert Bendelac
Nature Immunology 3, 1069–1074
(November 2002); doi:10.1038/ni844
| Abstract | Full Text (HTML/PDF) |

review article
To kill or be killed: viral evasion of apoptosis
Chris A. Benedict, Paula S. Norris and Carl F. Ware
Nature Immunology 3, 1013–1018
(November 2002); doi:10.1038/ni1102-1013
| Abstract | Full Text (HTML/PDF) |

review article
Evasion of innate immunity by parasitic protozoa
David Sacks and Alan Sher
Nature Immunology 3, 1041–1047
(November 2002); doi:10.1038/ni1102-1041
| Abstract | Full Text (HTML/PDF) |

article
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A₄ receptor
Mauro Perretti, Nan Chiang, Mylinh La, Iolanda M. Fierro, Stefano Marullo, Stephen J Getting, Egle Solito and Charles N. Serhan
Nature Medicine 8, 1296–1302
(November 2002); doi:10.1038/nm786
| Abstract | Full Text (HTML/PDF) |

review article
Innate and acquired immunity in atherogenesis
Christoph J. Binder, Mi-Kyung Chang, Peter X. Shaw, Yury I. Miller, Karsten Hartvigsen, Asheesh Dewan and Joseph L. Witztum
Nature Medicine 8, 1218–1226
(November 2002); doi:10.1038/nm1102-1218
| Abstract | Full Text (HTML/PDF) |

review article
The macrophage foam cell as a target for therapeutic intervention
Andrew C. Li and Christopher K. Glass
Nature Medicine 8, 1235–1242
(November 2002); doi:10.1038/nm1102-1235
| Abstract | Full Text (HTML/PDF) |

letters to nature
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Cecilia Garlanda, Emilio Hirsch, Silvia Bozza, Antonietta Salustri, Marika De Acetis, Rachele Nota, Alessia Maccagno, Federica Riva, Barbara Bottazzi, Giuseppe Peri, Andrea Doni, Luca Vago, Marina Botto, Rita De Santis, Paolo Carminati, Gregorio Siracusa, Fiorella Altruda, Annunciata Vecchi, Luigina Romani and Alberto Mantovani
Nature 420, 182–186
(14 November 2002); doi:10.1038/nature01195
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article
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
Gina Balciunaite, Marcel P. Keller, Egle Balciunaite, Luca Piali, Saulius Zuklys, Yves D. Mathieu, Jason Gill, Richard Boyd, Daniel J. Sussman and Georg A. Holländer
Nature Immunology 3, 1102–1108
(November 2002); doi:10.1038/ni850
| Abstract | Full Text (HTML/PDF) |

review article
Cancer immunoediting: from immunosurveillance to tumor escape
Gavin P. Dunn, Allen T. Bruce, Hiroaki Ikeda, Lloyd J. Old and Robert D. Schreiber
Nature Immunology 3, 991–998
(November 2002); doi:10.1038/ni1102-991
| Abstract | Full Text (HTML/PDF) |

review article
Viral evasion of natural killer cells
Jordan S. Orange, Marlys S. Fassett, Louise A. Koopman, Jonathan E. Boyson and Jack L. Strominger
Nature Immunology 3, 1006–1012
(November 2002); doi:10.1038/ni1102-1006
| Abstract | Full Text (HTML/PDF) |

review article
Chronic bacterial infections: living with unwanted guests
Douglas Young, Tracy Hussell and Gordon Dougan
Nature Immunology 3, 1026–1032
(November 2002); doi:10.1038/ni1102-1026
| Abstract | Full Text (HTML/PDF) |

review article
The immunology of susceptibility and resistance to leishmania major in mice
David Sacks and Nancy Noben-Trauth
Nature Reviews Immunology 2, 845–858
(November 2002); doi:10.1038/nri933
| Summary | Full Text (HTML / PDF) |

letters to nature
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
Sawsan Youssef, Olaf Stüve, Juan C. Patarroyo, Pedro J. Ruiz, Jennifer L. Radosevich, Eun Mi Hur, Manuel Bravo, Dennis J. Mitchell, Raymond A. Sobel, Lawrence Steinman and Scott S. Zamvil
Nature 420, 78–84
(07 November 2002); doi:10.1038/nature01158
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news and views
Medicine: Tackling multiple sclerosis
Hartmut Wekerle
Nature 420, 39–40
(07 November 2002); doi:10.1038/420039a
| Full Text (HTML / PDF) |

article
Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
Patrick S. Costello, Maighread Gallagher and Doreen A. Cantrell
Nature Immunology 3, 1082–1089
(November 2002); doi:10.1038/ni848
| Abstract | Full Text (HTML/PDF) |

article
Imaging antigen-induced PI3K activation in T cells
Julie Harriague and Georges Bismuth
Nature Immunology 3, 1090–1096
(November 2002); doi:10.1038/ni847
| Abstract | Full Text (HTML/PDF) |

news and views
Slick signaling
Andrey S.-Y. Shaw
Nature Immunology 3, 1058–1059
(November 2002); doi:10.1038/ni1102-1058
| Full Text (HTML/PDF) |

article
CTLA-4-Ig regulates tryptophan catabolism in vivo
Ursula Grohmann, Ciriana Orabona, Francesca Fallarino, Carmine Vacca, Filippo Calcinaro, Alberto Falorni, Paola Candeloro, Maria L. Belladonna, Roberta Bianchi, Maria C. Fioretti and Paolo Puccetti
Nature Immunology 3, 1097–1101
(November 2002); doi:10.1038/ni846
| Abstract | Full Text (HTML/PDF) |

news and views
When ligand becomes receptor—tolerance via B7 signaling on DCs
Erik B. Finger and Jeffrey A. Bluestone
Nature Immunology 3, 1056–1057
(November 2002); doi:10.1038/ni1102-1056
| Full Text (HTML/PDF) |

review article
Lymphocide: cytokines and the control of lymphoid homeostasis
Annette R. Khaled and Scott K. Durum
Nature Reviews Immunology 2, 817–830
(November 2002); doi:10.1038/nri931
| Summary | Full Text (HTML / PDF) |

original paper
Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines
Giulia De Falco, Luca Maria Neri, Maria De Falco, Cristiana Bellan, Zailin Yu, Antonio De Luca, Lorenzo Leoncini and Antonio Giordano
Oncogene 21, 7464–7470
(24 October 2002); doi:10.1038/sj.onc.1205967
| Full Text (HTML/PDF) |

October

letters to nature
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
Veronika Groh, Jennifer Wu, Cassian Yee and Thomas Spies
Nature 419, 734–738
(17 October 2002); doi:10.1038/nature01112
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news and views
Immunology: Catch us if you can
Wayne M. Yokoyama
Nature 419, 679–680
(17 October 2002); doi:10.1038/419679a
| Full Text (HTML / PDF) |

letters to nature
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
Lawryn H. Kasper, Fayçal Boussouar, Paul A. Ney, Carl W. Jackson, Jerold Rehg, Jan M. van Deursen and Paul K. Brindle
Nature 419, 738–743
(17 October 2002); doi:10.1038/nature01062
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article
Staging and resetting T cell activation in SMACs
Benjamin A. Freiberg, Hannah Kupfer, William Maslanik, Joe Delli, John Kappler, Dennis M. Zaller and Abraham Kupfer
Nature Immunology 3, 911–917
(October 2002); doi:10.1038/ni836
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article
Molecular anatomy of antigen-specific CD8⁺ T cell engagement and synapse formation in vivo
Dorian B. McGavern, Urs Christen and Michael B.A. Oldstone
Nature Immunology 3, 918–925
(October 2002); doi:10.1038/ni843
| First Paragraph | Full Text (HTML/PDF) |

article
B cells regulate autoimmunity by provision of IL-10
Simon Fillatreau, Claire H. Sweenie, Mandy J. McGeachy, David Gray and Stephen M. Anderton
Nature Immunology 3, 944–950
(October 2002); doi:10.1038/ni833
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review article
Development of ab t cells in the human thymus
Hergen Spits
Nature Reviews Immunology 2, 760–772
(October 2002); doi:10.1038/nri913
| Summary | Full Text (HTML/PDF) |

review article
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
Toby Lawrence, Derek A. Willoughby and Derek W. Gilroy
Nature Reviews Immunology 2, 787–795
(October 2002); doi:10.1038/nri915
| Summary | Full Text (HTML/PDF) |

article
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Estefania Claudio, Keith Brown, Sun Park, Hongshan Wang and Ulrich Siebenlist
Nature Immunology 3, 958–965
(October 2002); doi:10.1038/ni842
| Abstract | Full Text (HTML/PDF) |

news and views
Gatekeeper mechanisms for immature B cells
Xiao-Hong Sun and Paul W. Kincade
Nature Immunology 3, 898–899
(October 2002); doi:10.1038/ni1002-898
| Full Text (HTML/PDF) |

review article
Emerging roles of PPARs in inflammation and immunity
Raymond A. Daynes and Dallas C. Jones
Nature Reviews Immunology 2, 748–759
(October 2002); doi:10.1038/nri912
| Summary | Full Text (HTML / PDF) |

review article
Toll-like receptors as potential therapeutic targets for multiple diseases
Claudia Zuany-Amorim, John Hastewell and Christoph Walker
Nature Reviews Drug Discovery 1, 797–807
(October 2002); doi:10.1038/nrd914
| Summary | Full Text (HTML / PDF) |

news and views
Oxidized lipid protects against sepsis
Niels C. Riedemann and Peter A. Ward
Nature Medicine 8, 1084–1085
(October 2002); doi:10.1038/nm1002-1084
| Full Text (HTML/PDF) |

letters to nature
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, Noriko Takegahara, Chie Watanabe, EweSeng Ch'ng, Isao Ishida, Harutoshi Fujimura, Saburo Sakoda, Kanji Yoshida and Hitoshi Kikutani
Nature 419, 629–633
(10 October 2002); doi:10.1038/nature01037
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article
A GPI-linked isoform of the IgD receptor regulates resting B cell activation
Akanksha Chaturvedi, Zaved Siddiqui, Fahri Bayiroglu and Kanury V.S. Rao
Nature Immunology 3, 951–957
(October 2002); doi:10.1038/ni839
| Abstract | Full Text (HTML/PDF) |

article
Molecular anatomy of antigen-specific CD8⁺ T cell engagement and synapse formation in vivo
Dorian B. McGavern, Urs Christen and Michael B.A. Oldstone
Nature Immunology 3, 918–925
(October 2002); doi:10.1038/ni843
| First Paragraph | Full Text (HTML/PDF) |

review article
NF-κB regulation in the immune system
Qiutang Li and Inder M. Verma
Nature Reviews Immunology 2, 725–734
(October 2002); doi:10.1038/nri910
| Summary | Full Text (HTML / PDF) |

review article
Functional significance of the perforin/granzyme cell death pathway
Joseph A. Trapani and Mark J. Smyth
Nature Reviews Immunology 2, 735–747
(October 2002); doi:10.1038/nri911
| Summary | Full Text (HTML / PDF) |

letters to nature
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
Thomas Serwold, Federico Gonzalez, Jennifer Kim, Richard Jacob and Nilabh Shastri
Nature 419, 480–483
(03 October 2002); doi:10.1038/nature01074
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news and views
Immunology: Survival of the fitters
Hans-Georg Rammensee
Nature 419, 443–445
(03 October 2002); doi:10.1038/419443a
| Full Text (HTML / PDF) |

review article
The Yersinia Ysc-Yop 'Type III' weaponry
Guy R. Cornelis
Nature Reviews Molecular Cell Biology 3, 742–754
(October 2002); doi:10.1038/nrm932
| Summary | Full Text (HTML / PDF) |

article
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
Jeffrey C. Rathmell, Tullia Lindsten, Wei-Xing Zong, Ryan M. Cinalli and Craig B. Thompson
Nature Immunology 3, 932–939
(October 2002); doi:10.1038/ni834
| Abstract | Full Text (HTML/PDF) |

news and views
Bax and Bak: back-bone of T cell death
Philippe Bouillet and Andreas Strasser
Nature Immunology 3, 893–894
(October 2002); doi:10.1038/ni1002-893
| Full Text (HTML/PDF) |

review article
Regulation of mast-cell and basophil function and survival by IgE
Toshiaki Kawakami and Stephen J. Galli
Nature Reviews Immunology 2, 773–786
(October 2002); doi:10.1038/nri914
| Summary | Full Text (HTML / PDF) |

article
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
Niall C. Tebbutt, Andrew S. Giraud, Melissa Inglese, Brendan Jenkins, Paul Waring, Fiona J. Clay, Sina Malki, Barbara M. Alderman, Dianne Grail, Frédéric Hollande, Joan K. Heath and Matthias Ernst
Nature Medicine 8, 1089–1097
(October 2002); doi:10.1038/nm763
| Abstract | Full Text (HTML/PDF) |

news and views
Inflammation intersection: gp130 balances gut irritation and stomach cancer
Timothy C. Wang and James R. Goldenring
Nature Medicine 8, 1080–1082
(October 2002); doi:10.1038/nm1002-1080
| Full Text (HTML/PDF) |

September

letters to nature
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
Hyung J. Chun, Lixin Zheng, Manzoor Ahmad, Jin Wang, Christina K. Speirs, Richard M. Siegel, Janet K. Dale, Jennifer Puck, Joie Davis, Craig G. Hall, Suzanne Skoda-Smith, T. Prescott Atkinson, Stephen E. Straus and Michael J. Lenardo
Nature 419, 395–399
(26 September 2002); doi:10.1038/nature01063
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review article
Natural killer cell activation in mice and men: different triggers for similar weapons?
Francesco Colucci, James P. Di Santo and Paul J. Leibson
Nature Immunology 3, 807–813
(September 2002); doi:10.1038/ni0902-807
| Abstract | Full Text (HTML/PDF) |

article
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line
Ahmad Faili, Said Aoufouchi, Quentin Guéranger, Carole Zober, Anne Léon, Barbara Bertocci, Jean-Claude Weill and Claude-Agnès Reynaud
Nature Immunology 3, 815–821
(September 2002); doi:10.1038/ni826
| Abstract | Full Text (HTML/PDF) |

news and views
Does AID need another aid?
Tasuku Honjo
Nature Immunology 3, 800–801
(September 2002); doi:10.1038/ni0902-800
| Full Text (HTML/PDF) |

review article
WASp in immune-system organization and function
Adrian J. Thrasher
Nature Reviews Immunology 2, 635–646
(September 2002); doi:10.1038/nri884
| Summary | Full Text (HTML / PDF) |

review article
Natural killer cells and pregnancy
Ashley Moffett-King
Nature Reviews Immunology 2, 656–663
(September 2002); doi:10.1038/nri886
| Summary | Full Text (HTML / PDF) |

article
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A₄
Bruce D. Levy, George T. De Sanctis, Pallavi R. Devchand, Eugene Kim, Kate Ackerman, Birgitta A. Schmidt, Wojciech Szczeklik, Jeffrey M. Drazen and Charles N. Serhan
Nature Medicine 8, 1018–1023
(September 2002); doi:10.1038/nm748
| Abstract | Full Text (HTML/PDF) |

news and views
'Good' lipids for asthma
Marc Peters-Golden
Nature Medicine 8, 931–932
(September 2002); doi:10.1038/nm0902-931
| Full Text (HTML/PDF) |

article
Sensitization of IFN-g Jak-STAT signaling during macrophage activation
Xiaoyu Hu, Carmen Herrero, Wai-Ping Li, Taras T. Antoniv, Erik Falck-Pedersen, Alisa E. Koch, James M. Woods, G. Kenneth Haines and III Lionel B. Ivashkiv
Nature Immunology 3, 859–866
(September 2002); doi:10.1038/ni828
| Abstract | Full Text (HTML/PDF) |

article
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Mikhail B. Litinskiy, Bernardetta Nardelli, David M. Hilbert, Bing He, Andras Schaffer, Paolo Casali and Andrea Cerutti
Nature Immunology 3, 822–829
(September 2002); doi:10.1038/ni829
| Abstract | Full Text (HTML/PDF) |

news and views
BLySsful interactions between DCs and B cells
Andrew J. Macpherson and Alain Lamarre
Nature Immunology 3, 798–800
(September 2002); doi:10.1038/ni0902-798
| Full Text (HTML/PDF) |

review article
Coeliac disease: dissecting a complex inflammatory disorder
Ludvig M. Sollid
Nature Reviews Immunology 2, 647–655
(September 2002); doi:10.1038/nri885
| Summary | Full Text (HTML / PDF) |

article
Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
Omid Akbari, Gordon J. Freeman, Everett H. Meyer, Edward A. Greenfield, Tammy T. Chang, Arlene H. Sharpe, Gerald Berry, Rosemarie H. DeKruyff and Dale T. Umetsu
Nature Medicine 8, 1024–1032
(September 2002); doi:10.1038/nm745
| Abstract | Full Text (HTML/PDF) |

article
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
Javier Di Noia and Michael S. Neuberger
Nature 419, 43–48
(05 September 2002); doi:10.1038/nature00981
| Summary | Full Text (HTML / PDF) |

news and views
Immunology: The roots of antibody diversity
Patricia J. Gearhart
Nature 419, 29–31
(05 September 2002); doi:10.1038/419029a
| Full Text (HTML / PDF) |

letters to nature
Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
Valery N. Bochkov, Alexandra Kadl, Joakim Huber, Florian Gruber, Bernd R. Binder and Norbert Leitinger
Nature 419, 77–81
(05 September 2002); doi:10.1038/nature01023
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article
A requirement for CARMA1 in TCR-induced NF-kB activation
Donghai Wang, Yun You, Sara M. Case, Linda M. McAllister-Lucas, Lin Wang, Peter S. DiStefano, Gabriel Nuñez, John Bertin and Xin Lin
Nature Immunology 3, 830–835
(September 2002); doi:10.1038/ni824
| Abstract | Full Text (HTML/PDF) |

article
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kB activation
Olivier Gaide, Benoît Favier, Daniel F. Legler, David Bonnet, Brian Brissoni, Salvatore Valitutti, Claude Bron, Jürg Tschopp and Margot Thome
Nature Immunology 3, 836–843
(September 2002); doi:10.1038/ni830
| Abstract | Full Text (HTML/PDF) |

news and views
Up the down staircase
David Wallach
Nature Immunology 3, 802–803
(September 2002); doi:10.1038/ni0902-802
| Full Text (HTML/PDF) |

review article
Nf-kb, chemokine gene transcription and tumour growth
Ann Richmond
Nature Reviews Immunology 2, 664–674
(September 2002); doi:10.1038/nri887
| Abstract | Full Text (HTML/PDF) |

article
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
Sang Heui Seo, Erich Hoffmann and Robert G. Webster
Nature Medicine 8, 950–954
(September 2002); doi:10.1038/nm757
| Abstract | Full Text (HTML/PDF) |

news and views
The makings of a killer
Peter Palese, Christopher F. Basler and Adolfo García-Sastre
Nature Medicine 8, 927–928
(September 2002); doi:10.1038/nm0902-927
| Full Text (HTML/PDF) |

progress
Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae
Tom H.M. Ottenhoff, Frank A.W. Verreck, Elgin G.R. Lichtenauer-Kaligis, Marieke A. Hoeve, Ozden Sanal and Jaap T. van Dissel
Nature Genetics 32, 97–105
(September 2002); doi:10.1038/ng0902-97
| Abstract | Full Text (HTML/PDF) |

article
PI3K-mediated negative feedback regulation of IL-12 production in DCs
Taro Fukao, Masanobu Tanabe, Yasuo Terauchi, Takayuki Ota, Satoshi Matsuda, Tomoichiro Asano, Takashi Kadowaki, Tsutomu Takeuchi and Shigeo Koyasu
Nature Immunology 3, 875–881
(September 2002); doi:10.1038/ni825
| Abstract | Full Text (HTML/PDF) |

article
Cross-primed CD8⁺ T cells mediate graft rejection via a distinct effector pathway
Anna Valujskikh, Olivier Lantz, Susanna Celli, Polly Matzinger and Peter S. Heeger
Nature Immunology 3, 844–851
(September 2002); doi:10.1038/ni831
| Abstract | Full Text (HTML/PDF) |

news and views
Transplantation—caught in the crossfire!
Herman Waldmann
Nature Immunology 3, 803–804
(September 2002); doi:10.1038/ni0902-803
| Full Text (HTML/PDF) |

review article
Viruses and interferon: A fight for supremacy
Michael G. Katze, Yupeng He and Michael Gale Jr
Nature Reviews Immunology 2, 675–687
(September 2002); doi:10.1038/nri888
| Summary | Full Text (HTML / PDF) |

August

letters to nature
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
Marianne Boes, Jan Cerny , Ramiro Massol, Marjolein Op den Brouw, Tom Kirchhausen, Jianzhu Chen and Hidde L. Ploegh
Nature 418, 983–988
(29 August 2002); doi:10.1038/nature01004
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letters to nature
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
Amy Chow, Derek Toomre, Wendy Garrett and Ira Mellman
Nature 418, 988–994
(29 August 2002); doi:10.1038/nature01006
| First Paragraph | Full Text (HTML / PDF) |

news and views
Immunology: Inside the professionals
Jonathan W. Yewdell and David C. Tscharke
Nature 418, 923–924
(29 August 2002); doi:10.1038/418923a
| Full Text (HTML / PDF) |

news and views
Chromosome instability: lessons from HIV
Jan Paul Medema and René H. Medema
Nature Cell Biology 4, E191
(August 2002); doi:10.1038/ncb0802-e191b
| Full Text (HTML/PDF) |

news and views
'ER we go
Rachel Smallridge
Nature Cell Biology 4, E193
(August 2002); doi:10.1038/ncb0802-e193
| Full Text (HTML/PDF) |

article
Origin of regulatory T cells with known specificity for antigen
Irina Apostolou, Adelaida Sarukhan, Ludger Klein and Harald von Boehmer
Nature Immunology 3, 756–763
(August 2002); doi:10.1038/ni816
| Abstract | Full Text (HTML/PDF) |

article
Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
Zheng Xu and Arthur Weiss
Nature Immunology 3, 764–771
(August 2002); doi:10.1038/ni822
| Abstract | Full Text (HTML/PDF) |

review article
Exosomes: Composition, Biogenesis and Function
Clotilde Théry, Laurence Zitvogel and Sebastian Amigorena
Nature Reviews Immunology 2, 569–579
(August 2002); doi:10.1038/nri855
| Abstract | Full Text (HTML/PDF) |

article
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
Lena Alexopoulou, Venetta Thomas, Markus Schnare, Yves Lobet, Juan Anguita, Robert T. Schoen, Ruslan Medzhitov, Erol Fikrig and Richard A. Flavell
Nature Medicine 8, 878–884
(August 2002); doi:10.1038/nm732
| Abstract | Full Text (HTML/PDF) |

article
Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Zoltan A. Nagy, Bernd Hubner, Corinna Löhning, Robert Rauchenberger, Silke Reiffert, Elisabeth Thomassen-Wolf, Stefan Zahn, Sigmar Leyer, Eva M. Schier, Angelika Zahradnik, Christoph Brunner, Kurt Lobenwein, Benno Rattel, Michael Stanglmaier, Michael Hallek, Mark Wing, Steve Anderson, Matt Dunn, Titus Kretzschmar and Michael Tesar
Nature Medicine 8, 801–807
(August 2002); doi:10.1038/nm736
| Abstract | Full Text (HTML/PDF) |

news and views
DR's orders: Human antibody kills tumors by direct signaling
Dan L. Longo
Nature Medicine 8, 781–783
(August 2002); doi:10.1038/nm0802-781
| Full Text (HTML/PDF) |

news and views
Immunology: A block at the toll gate
Tak W. Mak and Wen-Chen Yeh
Nature 418, 835–836
(22 August 2002); doi:10.1038/418835a
| Full Text (HTML / PDF) |

article
Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1
Lisa J. Matthias, Patricia T.W. Yam, Xing-Mai Jiang, Nick Vandegraaff, Peng Li, Pantelis Poumbourios, Neil Donoghue and Philip J. Hogg
Nature Immunology 3, 727–732
(August 2002); doi:10.1038/ni815
| Abstract | Full Text (HTML/PDF) |

news and views
HIV entry: are all receptors created equal?
Mark A. Goldsmith and Robert W. Doms
Nature Immunology 3, 709–710
(August 2002); doi:10.1038/ni819
| Full Text (HTML/PDF) |

review article
Roles of Fc receptors in autoimmunity
Toshiyuki Takai
Nature Reviews Immunology 2, 580–592
(August 2002); doi:10.1038/nri856
| Summary | Full Text (HTML / PDF) |

perspectives
Opinion: Gene therapy of severe combined immunodeficiencies
Alain Fischer, Salima Hacein-Bey and Marina Cavazzana-Calvo
Nature Reviews Immunology 2, 615–621
(August 2002); doi:10.1038/nri859
| Summary | Full Text (HTML / PDF) |

article
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains
Stephan D. Gadola, Nathan R. Zaccai, Karl Harlos, Dawn Shepherd, Julio C. Castro-Palomino, Gerd Ritter, Richard R. Schmidt, E. Yvonne Jones and Vincenzo Cerundolo
Nature Immunology 3, 721–726
(August 2002); doi:10.1038/ni821
| Abstract | Full Text (HTML/PDF) |

news and views
The CD1b structure: antigen presentation adapts to a high-fat diet
Kayvan R. Niazi, Steven A. Porcelli and Robert L. Modlin
Nature Immunology 3, 703–704
(August 2002); doi:10.1038/ni0802-703
| Full Text (HTML/PDF) |

review article
Asthma: an epidemic of dysregulated immunity
Dale T. Umetsu, Jennifer J. McIntire, Omid Akbari, Claudia Macaubas and Rosemarie H. DeKruyff
Nature Immunology 3, 715–720
(August 2002); doi:10.1038/ni0802-715
| Abstract | Full Text (HTML/PDF) |

review article
Maintaining the norm: T-Cell homeostasis
Stephen C. Jameson
Nature Reviews Immunology 2, 547–556
(August 2002); doi:10.1038/nri853
| Summary | Full Text (HTML / PDF) |

review article
Endogenous kynurenines as targets for drug discovery and development
Trevor W. Stone and L. Gail Darlington
Nature Reviews Drug Discovery 1, 609–620
(August 2002); doi:10.1038/nrd870
| Summary | Full Text (HTML / PDF) |

article
A nonredundant role for the adapter protein Shc in thymic T cell development
Li Zhang, Victoria Camerini, Timothy P. Bender and Kodi S. Ravichandran
Nature Immunology 3, 749–755
(August 2002); doi:10.1038/ni820
| Abstract | Full Text (HTML/PDF) |

news and views
Shc: a dominant player after ten seasons
Ed Palmer
Nature Immunology 3, 710–711
(August 2002); doi:10.1038/ni0802-710
| Full Text (HTML/PDF) |

review article
The unconventional lifestyle of NKT Cells
Mitchell Kronenberg and Laurent Gapin
Nature Reviews Immunology 2, 557–568
(August 2002); doi:10.1038/nri854
| Abstract | Full Text (HTML/PDF) |

review article
The hare and the tortoise: an embryonic haematopoietic race
Isabelle Godin and Ana Cumano
Nature Reviews Immunology 2, 593–604
(August 2002); doi:10.1038/nri857
| Abstract | Full Text (HTML/PDF) |

brief communication
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
Yan Zhu, Tao Yu, Xiao-Chun Zhang, Takashi Nagasawa, Jane Y. Wu and Yi Rao
Nature Neuroscience 5, 719–720
(August 2002); doi:10.1038/nn881
| First Paragraph | Full Text (HTML/PDF) |

letter
Two-step binding mechanism for T-cell receptor recognition of peptide-MHC
Lawren C. Wu, Delphine S. Tuot, Daniel S. Lyons, K. Christopher Garcia and Mark M. Davis
Nature 418, 552–556
(1 August 2002); doi:10.1038/nature00920
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article
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
Valentino Parravicini, Massimo Gadina, Martina Kovarova, Sandra Odom, Claudia Gonzalez-Espinosa, Yasuko Furumoto, Shinichiroh Saitoh, Lawrence E. Samelson, John J. O'Shea and Juan Rivera
Nature Immunology 3, 741–748
(August 2002); doi:10.1038/ni817
| Abstract | Full Text (HTML/PDF) |

news and views
Uncovering new complexities in mast cell signaling
Monica J.S. Nadler and Jean-Pierre Kinet
Nature Immunology 3, 707–708
(August 2002); doi:10.1038/ni0802-707
| Full Text (HTML/PDF) |

article
PKC-b controls IkB kinase lipid raft recruitment and activation in response to BCR signaling
Thomas T. Su, Beichu Guo, Yuko Kawakami, Karen Sommer, Keun Chae, Lisa A. Humphries, Roberta M. Kato, Shin Kang, Lisa Patrone, Randolph Wall, Michael Teitell, Michael Leitges, Toshiaki Kawakami and David J. Rawlings
Nature Immunology 3, 780–786
(August 2002); doi:10.1038/ni823
| Abstract | Full Text (HTML/PDF) |

letter
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
Norihide Yokoi, Kajuro Komeda, He-Yao Wang, Hideki Yano, Kazuhiro Kitada, Yuka Saitoh, Yutaka Seino, Kazuki Yasuda, Tadao Serikawa and Susumu Seino
Nature Genetics 31, 391–394
(August 2002); doi:10.1038/ng927
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article
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman, Xiaozhu Huang, Laura L. Koth, Grace H. Chang, Gregory M. Dolganov, Zhou Zhu, Jack A. Elias, Dean Sheppard and David J. Erle
Nature Medicine 8, 885–889
(August 2002); doi:10.1038/nm734
| Abstract | Full Text (HTML/PDF) |

research article
Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device
Noo Li Jeon, Harihara Baskaran, Stephan K. W. Dertinger, George M. Whitesides, Livingston Van De Water and Mehmet Toner
Nature Biotechnology 20, 826–830
(August 2002); doi:10.1038/nbt712
| Abstract | Full Text (HTML/PDF) |

July

news and views
Genetics: Inherit the wheeze
Jeffrey M. Drazen and Scott T. Weiss
Nature 418, 383–384
(25 July 2002); doi:10.1038/418383a
| Full Text (HTML/PDF) |

letters to nature
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Paul Van Eerdewegh, Randall D. Little, Josée Dupuis, Richard G. Del Mastro, Kathy Falls, Jason Simon, Dana Torrey, Sunil Pandit, Joyce McKenny, Karen Braunschweiger, Alison Walsh, Ziying Liu, Brooke Hayward, Colleen Folz, Susan P. Manning, Alicia Bawa, Lisa Saracino, Michelle Thackston, Youssef Benchekroun, Neva Capparell, Mei Wang, Ron Adair, Yun Feng, JoAnn Dubois, Michael G. FitzGerald, Hui Huang, René Gibson, Kristina M. Allen, Alex Pedan, Melvyn R. Danzig, Shelby P. Umland, Robert W. Egan, Francis M. Cuss, Steuart Rorke, Joanne B. Clough, John W. Holloway, Stephen T. Holgate and Tim P. Keith
Nature 418, 426–430
(25 July 2002); doi:10.1038/nature00878
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letters to nature
Distinct molecular mechanism for initiating TRAF6 signalling
Hong Ye, Joseph R. Arron, Betty Lamothe, Maurizio Cirilli, Takashi Kobayashi, Nirupama K. Shevde, Deena Segal, Oki K. Dzivenu, Masha Vologodskaia, Mijung Yim, Khoi Du, Sujay Singh, J. Wesley Pike, Bryant G. Darnay, Yongwon Choi and Hao Wu
Nature 418, 443–447
(25 July 2002); doi:10.1038/nature00888
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article
T_H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
Orly Avni, Dong Lee, Fernando Macian, Susanne J. Szabo, Laurie H. Glimcher and Anjana Rao
Nature Immunology 3, 643–651
(July 2002); doi:10.1038/ni808
| Abstract | Full Text (HTML/PDF) |

article
Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP
Vassili Soumelis, Pedro A. Reche, Holger Kanzler, Wei Yuan, Gina Edward, Bernhart Homey, Michel Gilliet, Steve Ho, Svetlana Antonenko, Annti Lauerma, Kathleen Smith, Daniel Gorman, Sandra Zurawski, Jon Abrams, Satish Menon, Terri McClanahan, Rene de Waal-Malefyt, Fernando Bazan, Robert A. Kastelein and Yong-Jun Liu
Nature Immunology 3, 673–680
(July 2002); doi:10.1038/ni805
| Abstract | Full Text (HTML/PDF) |

news and views
TSLP: finally in the limelight
Warren J. Leonard
Nature Immunology 3, 605–607
(July 2002); doi:10.1038/ni0702-605
| Full Text (HTML/PDF) |

article
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
Yoshinori Nagai, Sachiko Akashi, Masakazu Nagafuku, Masato Ogata, Yoichiro Iwakura, Shizuo Akira, Toshio Kitamura, Atsushi Kosugi, Masao Kimoto and Kensuke Miyake
Nature Immunology 3, 667–672
(July 2002); doi:10.1038/ni809
| Abstract | Full Text (HTML/PDF) |

article
Hlx is induced by and genetically interacts with T-bet to promote heritable T_H1 gene induction
Alan C. Mullen, Anne S. Hutchins, Frances A. High, Hubert W. Lee, Kara J. Sykes, Lewis A. Chodosh and Steven L. Reiner
Nature Immunology 3, 652–658
(July 2002); doi:10.1038/ni807
| Abstract | Full Text (HTML/PDF) |

review article
CTLA-4: new insights into its biological function and use in tumor immunotherapy
Jackson G. Egen, Michael S. Kuhns and James P. Allison
Nature Immunology 3, 611–618
(July 2002); doi:10.1038/ni0702-611
| Abstract | Full Text (HTML/PDF) |

review article
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
Martin Turner and Daniel D. Billadeau
Nature Reviews Immunology 2, 476–486
(July 2002); doi:10.1038/nri840
| Abstract | Full Text (HTML/PDF) |

review article
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
Warner C. Greene and B. Matija Peterlin
Nature Medicine 8, 673–680
(July 2002); doi:10.1038/nm0702-673
| Abstract | Full Text (HTML/PDF) |

letter to nature
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Paola Scaffidi, Tom Misteli and Marco E. Bianchi
Nature 418, 191–195
(11 July 2002); doi:10.1038/nature00858
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
Tian H. Chi, Mimi Wan, Keji Zhao, Ichiro Taniuchi, Lei Chen, Dan R. Littman and Gerald R. Crabtree
Nature 418, 195–199
(11 July 2002); doi:10.1038/nature00876
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letter to nature
Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
Simon Brown, Isabelle Heinisch, Ewan Ross, Kate Shaw, Chris D. Buckley and John Savill
Nature 418, 200–203
(11 July 2002); doi:10.1038/nature00811
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news and views
Apoptosis: Repulsive encounters
Giovanna Chimini
Nature 418, 139–141
(11 July 2002); doi:10.1038/418139a
| Full Text (HTML/PDF) |

brief communication
A PtdInsP₃- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
Orion D. Weiner, Paul O. Neilsen, Glenn D. Prestwich, Marc W. Kirschner, Lewis C. Cantley and Henry R. Bourne
Nature Cell Biology 4, 509–513
(July 2002); doi:10.1038/ncb811
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brief communication
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
Fei Wang, Paul Herzmark, Orion D. Weiner, Supriya Srinivasan, Guy Servant and Henry R. Bourne
Nature Cell Biology 4, 513–518
(3); doi:10.1038/ncb810
| First Paragraph | Full Text (HTML/PDF) |

news and views
Leading the way
Ruedi Meili and Richard A. Firtel
Nature Cell Biology 4, E171
(July 2002); doi:10.1038/ncb0702-e171
| Full Text (HTML/PDF) |

article
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
Isabelle Petit, Martine Szyper-Kravitz, Arnon Nagler, Meir Lahav, Amnon Peled, Liliana Habler, Tanya Ponomaryov, Russell S. Taichman, Fernando Arenzana-Seisdedos, Nobutaka Fujii, Judith Sandbank, Dov Zipori and Tsvee Lapidot
Nature Immunology 3, 687–694
(July 2002); doi:10.1038/ni813
| Abstract | Full Text (HTML/PDF) |

article
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
Triantafyllos Chavakis, Muzaffar Hussain, Sandip M. Kanse, Georg Peters, Reinhard G. Bretzel, Jan-Ingmar Flock, Mathias Herrmann and Klaus T. Preissner
Nature Medicine 8, 687–693
(July 2002); doi:10.1038/nm728
| Abstract | Full Text (HTML/PDF) |

article
Myosin X is a downstream effector of PI(3)K during phagocytosis
Dianne Cox, Jonathan S. Berg, Michael Cammer, John O. Chinegwundoh, Benjamin M. Dale, Richard E. Cheney and Steven Greenberg
Nature Cell Biology 4, 469–477
(3); doi:10.1038/ncb805
| Abstract | Full Text (HTML/PDF) |

news and views
May the force be with you: Myosin-X in phagocytosis.
Philippe Chavrier
Nature Cell Biology 4, E169
(July 2002); doi:10.1038/ncb0702-e169
| Full Text (HTML/PDF) |

article
Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell-induced inflammation
Julien C. Marie, Anne L. Astier, Pierre Rivailler, Chantal Rabourdin-Combe, T. Fabian Wild and Branka Horvat
Nature Immunology 3, 659–666
(July 2002); doi:10.1038/ni810
| Abstract | Full Text (HTML/PDF) |

review article
BAFF: A fundamental survival factor for B cells
Fabienne Mackay and Jeffrey L. Browning
Nature Reviews Immunology 2, 465–475
(July 2002); doi:10.1038/nri844
| Abstract | Full Text (HTML/PDF) |

June

article
Signaling via letterbR on the lamina propria stromal cells of the gut is required for IgA production
Hyung-Sik Kang, Robert K. Chin, Yang Wang, Ping Yu, Jun Wang, Kenneth A. Newell and Yang-Xin Fu
Nature Immunology 3, 576–582
(June 2002); doi:10.1038/ni795
| Abstract | Full Text (HTML/PDF) |

review article
T-cell signalling and autoimmunity: molecular mechanisms of disease
Pamela S. Ohashi
Nature Reviews Immunology 2, 427–438
(June 2002); doi:10.1038/nri822
| Abstract | Full Text (HTML/PDF) |

article
Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Takanori Teshima, Rainer Ordemann, Pavan Reddy, Svetlana Gagin, Chen Liu, Kenneth R. Cooke and James L. M. Ferrara
Nature Medicine 8, 575–581
(June 2002); doi:10.1038/nm0602-575
| Abstract | Full Text (HTML/PDF) |

article
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung
Edward E.S. Nieuwenhuis, Tetsuya Matsumoto, Mark Exley, Robbert A. Schleipman, Jonathan Glickman, Dan T. Bailey, Nadia Corazza, Sean P. Colgan, Andrew B. Onderdonk and Richard S. Blumberg
Nature Medicine 8, 588–593
(June 2002); doi:10.1038/nm0602-588
| Abstract | Full Text (HTML/PDF) |

news and views
The healing touch of epidermal T cells
Willi K. Born and Rebecca L. O'Brien
Nature Medicine 8, 560–561
(June 2002); doi:10.1038/nm0602-560
| Full Text (HTML/PDF) |

article
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4⁺ T cells
Maryam Afkarian, John R. Sedy, Jianfei Yang, Nils G. Jacobson, Nezih Cereb, Soo Y. Yang, Theresa L. Murphy and Kenneth M. Murphy
Nature Immunology 3, 549–557
(June 2002); doi:10.1038/ni794
| Abstract | Full Text (HTML/PDF) |

news and views
Regulation of T_HI differentiation - controlling the controllers
John J. O'Shea and William E. Paul
Nature Immunology 3, 506–508
(June 2002); doi:10.1038/ni0602-506
| Full Text (HTML/PDF) |

review article
Cytotoxic t lymphocytes: all roads lead to death
Michele Barry and R. Chris Bleackley
Nature Reviews Immunology 2, 401–409
(June 2002); doi:10.1038/nri819
| Abstract | Full Text (HTML/PDF) |

article
Role for Bcl-6 in the generation and maintenance of memory CD8⁺ T cells
Hirohito Ichii, Akemi Sakamoto, Masahiko Hatano, Seiji Okada, Hirochika Toyama, Shinsuke Taki, Masafumi Arima, Yoshikazu Kuroda & Takeshi Tokuhisa
Nature Immunology 3, 558–563
(June 2002); doi:10.1038/ni802
| Abstract | Full Text (HTML/PDF) |

article
Early TCRa expression generates TCRag complexes that signal the DN-to-DP transition and impair development
Batu Erman, Lionel Feigenbaum, John E. Coligan & Alfred Singer
Nature Immunology 3, 564–569
(June 2002); doi:10.1038/ni800
| Abstract | Full Text (HTML/PDF) |

article
Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells
Claudia Zuany-Amorim, Elzbieta Sawicka, Corinne Manlius, Alain Le Moine, Laura R. Brunet, David M. Kemeny, Gareth Bowen, Graham Rook and Christoph Walker
Nature Medicine 8, 625–629
(June 2002); doi:10.1038/nm0602-625
| Abstract | Full Text (HTML/PDF) |

article
Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus
Corina M. Borza and Lindsey M. Hutt-Fletcher
Nature Medicine 8, 594–599
(June 2002); doi:10.1038/nm0602-594
| Abstract | Full Text (HTML/PDF) |

news and views
Cell-switching and kissing
Paul J. Farrell
Nature Medicine 8, 559–560
(June 2002); doi:10.1038/nm0602-559
| Full Text (HTML/PDF) |

review article
The role of Th1/Th2 polarization in mucosal immunity
Markus F. Neurath, Susetta Finotto and Laurie H. Glimcher
Nature Medicine 8, 567–573
(June 2002); doi:10.1038/nm0602-567
| Abstract | Full Text (HTML/PDF) |

review article
Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses
Cassian Yee and Philip Greenberg
Nature Reviews Cancer 2, 409–419
(June 2002); doi:10.1038/nrc820
| Abstract | Full Text (HTML/PDF) |

review article
Suppressors of cytokine signalling (SOCS) in the immune system
Warren S. Alexander
Nature Reviews Immunology 2, 410–416
(SOCS); doi:10.1038/nri818
| Abstract | Full Text (HTML/PDF) |

review article
New treatments for COPD
Peter J. Barnes
Nature Reviews Drug Discovery 1, 437–446
(June 2002); doi:10.1038/nrd820
| Abstract | Full Text (HTML/PDF) |

May

review article
Aids-related malignancies
Chris Boshoff and Robin Weiss
Nature Reviews Cancer 2, 373–382
(May 2002); doi:10.1038/nrc797
| Abstract | Full Text (HTML/PDF) |

perspectives
Timeline: Development of anti-TNF therapy for rheumatoid arthritis
Marc Feldmann
Nature Reviews Immunology 2, 364–371
(May 2002); doi:10.1038/nri802
| Abstract | Full Text (HTML/PDF) |

review article
Regulation of B-cell signal transduction by adaptor proteins
Tomohiro Kurosaki
Nature Reviews Immunology 2, 354–363
(May 2002); doi:10.1038/nri801
| Abstract | Full Text (HTML/PDF) |

review article
MARGINAL-ZONE B CELLS
Flavius Martin and John F. Kearney
Nature Reviews Immunology 2, 323–335
(May 2002); doi:10.1038/nri799
| Abstract | Full Text (HTML/PDF) |

review article
T-cell development and the CD4-CD8 lineage decision
Ronald N. Germain
Nature Reviews Immunology 2, 309–322
(May 2002); doi:10.1038/nri798
| Abstract | Full Text (HTML/PDF) |

review article
Structural mechanisms of costimulation
Jean-Claude D. Schwartz, Xuewu Zhang, Stanley G. Nathenson and Steven C. Almo
Nature Immunology 3, 427–434
(May 2002); doi:10.1038/ni0502-427
| Abstract | Full Text (HTML/PDF) |

research article
Reprogramming fibroblasts to express T-cell functions using cell extracts
Anne-Mari Håkelien, Helga B. Landsverk, James M. Robl, Bjørn S. Skålhegg and Philippe Collas
Nature Biotechnology 20, 460–466
(May 2002); doi:10.1038/nbt0502-460
| Abstract | Full Text (HTML/PDF) |

article
Regulation of the TCRa repertoire by the survival window of CD4⁺CD8⁺ thymocytes
Jian Guo, Abbas Hawwari, Hong Li, Zuoming Sun, Sanjeev K. Mahanta, Dan R. Littman, Michael S. Krangel and You-Wen He
Nature Immunology 3, 469–476
(May 2002); doi:10.1038/ni791
| Abstract | Full Text (HTML/PDF) |

news and views
A role for Toll in autoimmunity
Arthur M. Krieg
Nature Immunology 3, 423–424
(May 2002); doi:10.1038/ni0502-423
| Full Text (HTML/PDF) |

article
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells
Cory L. Ahonen, Eric M. Manning, Loren D. Erickson, Brian P. O'Connor, Evan F. Lind, Steven S. Pullen, Marilyn R. Kehry and Randolph J. Noelle
Nature Immunology 3, 451–456
(May 2002); doi:10.1038/ni792
| Abstract | Full Text (HTML/PDF) |

letters to nature
Neutrophil elastase targets virulence factors of enterobacteria
Yvette Weinrauch, Doreen Drujan, Steven D. Shapiro, Jerrold Weiss and Arturo Zychlinsky
Nature 417, 91–94
(May 2002); doi:10.1038/417091a
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article
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
Kenji Tanigaki, Hua Han, Norio Yamamoto, Kei Tashiro, Masaya Ikegawa, Kazuki Kuroda, Akira Suzuki, Toru Nakano and Tasuku Honjo
Nature Immunology 3, 443–450
(May 2002); doi:10.1038/ni793
| Abstract | Full Text (HTML/PDF) |

article
A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
Rafaèle Tordjman, Yves Lepelletier, Valérie Lemarchandel, Marie Cambot, Philippe Gaulard, Olivier Hermine and Paul-Henri Roméo
Nature Immunology 3, 477–482
(May 2002); doi:10.1038/ni789
| Abstract | Full Text (HTML/PDF) |

news and views
Neuropilin-1: another neuronal molecule in the "immunological synapse"
Christoph Wülfing and Fabio Rupp
Nature Immunology 3, 418–419
(May 2002); doi:10.1038/ni0502-418
| Full Text (HTML/PDF) |

article
A critical role for the cytoplasmic tail of pTa in T lymphocyte development
Iannis Aifantis, Christine Borowski, Fotini Gounari, H. Daniel Lacorazza, Janko Nikolich-Zugich and
Nature Immunology 3, 483–488
(May 2002); doi:10.1038/ni779
| Abstract | Full Text (HTML/PDF) |

article
Tracing lymphopoiesis with the aid of a pTa-controlled reporter gene
Fotini Gounari, Iannis Aifantis, Colin Martin, Hans-Joerg Fehling, Sonja Hoeflinger, Philip Leder, Harald von Boehmer and Boris Reizis
Nature Immunology 3, 489–496
(May 2002); doi:10.1038/ni778
| Abstract | Full Text (HTML/PDF) |

news and views
A new spin on an unusual tail
Nigel Killeen
Nature Immunology 3, 419–421
(May 2002); doi:10.1038/ni0502-419
| Full Text (HTML/PDF) |

review article
NEW THERAPEUTICS THAT MODULATE CHEMOKINE NETWORKS
Matthias K. Schwarz and Timothy N. C. Wells
Nature Reviews Drug Discovery 1, 347–358
(May 2002); doi:10.1038/nrd795
| Abstract | Full Text (HTML/PDF) |

April

article
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness
Norikatsu Mizumoto, Tadashi Kumamoto, Simon C. Robson, Jean Sévigny, Hiroyuki Matsue, Keiichi Enjyoji and Akira Takashima
Nature Medicine 8, 358–365
(April 2002); doi:10.1038/nm0402-358
| Abstract | Full Text (HTML/PDF) |

news and views
The skinny on CD39 in immunity and inflammation
Richard D. Granstein
Nature Medicine 8, 336–338
(April 2002); doi:10.1038/nm0402-336
| Full Text (HTML/PDF) |

news and views
Killed by leukocytes that don't know when to leave
Dean Sheppard
Nature Immunology 3, 337–338
(April 2002); doi:10.1038/ni0402-337
| Full Text (HTML/PDF) |

article
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency
David B. Corry, Kirtee Rishi, John Kanellis, Attila Kiss, Li-zhen Song, Jie Xu, Lili Feng, Zena Werb and Farrah Kheradmand
Nature Immunology 3, 347–353
(April 2002); doi:10.1038/ni773
| Abstract | Full Text (HTML/PDF) |

article
Target cell defense prevents the development of diabetes after viral infection
Malin Flodström, Amy Maday, Deepika Balakrishna, Mary Malo Cleary, Akihiko Yoshimura and Nora Sarvetnick
Nature Immunology 3, 373–382
(April 2002); doi:10.1038/ni771
| Abstract | Full Text (HTML/PDF) |

news and views
Type 1 diabetes: virus infection or autoimmune disease?
DeLisa Fairweather and Noel R. Rose
Nature Immunology 3, 338–340
(April 2002); doi:10.1038/ni0402-338
| Full Text (HTML/PDF) |

news and views
Revival of the autoantibody model in rheumatoid arthritis
Toshio Hirano
Nature Immunology 3, 342–344
(April 2002); doi:10.1038/ni0402-342
| Abstract | Full Text (HTML/PDF) |

article
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
Isao Matsumoto, Mariana Maccioni, David M. Lee, Madelon Maurice, Barry Simmons, Michael Brenner, Diane Mathis and Christophe Benoist
Nature Immunology 3, 360–365
(April 2002); doi:10.1038/ni772
| Abstract | Full Text (HTML/PDF) |

article
Dynamic visualization of a joint-specific autoimmune response through positron emission tomography
Brian T. Wipke, Zheng Wang, Joonyoung Kim, Timothy J. McCarthy and Paul M. Allen
Nature Immunology 3, 366–372
(April 2002); doi:10.1038/ni775
| Abstract | Full Text (HTML/PDF) |

article
Down-regulation of diabetogenic CD4⁺ T cells by a soluble dimeric peptide-MHC class II chimera
Sofia Casares, Alicia Hurtado, Robert C. McEvoy, Adelaida Sarukhan, Harald von Boehmer and Teodor-Doru Brumeanu
Nature Immunology 3, 383–391
(April 2002); doi:10.1038/ni770
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article
TLR4, but not TLR2, mediates IFN-b-induced STAT1a/b-dependent gene expression in macrophages
Vladimir Toshchakov, Bryan W. Jones, Pin-Yu Perera, Karen Thomas, M. Joshua Cody, Shuling Zhang, Bryan R. G. Williams, Jennifer Major, Thomas A. Hamilton, Matthew J. Fenton and Stefanie N. Vogel
Nature Immunology 3, 392–398
(April 2002); doi:10.1038/ni774
| Abstract | Full Text (HTML/PDF) |

letter
Structural basis of BLyS receptor recognition
Deena A. Oren, Yuling Li, Yulia Volovik, Tina S. Morris, Chhaya Dharia, Kalyan Das, Olga Galperina, Reiner Gentz and Eddy Arnold
Nature Structural Biology 9, 288–292
(April 2002); doi:10.1038/nsb769
| Abstract | Full Text (HTML/PDF) |

research article
Multiplexed protein profiling on microarrays by rolling-circle amplification
Barry Schweitzer, Scott Roberts, Brian Grimwade, Weiping Shao, Minjuan Wang, Qin Fu, Quiping Shu, Isabelle Laroche, Zhimin Zhou, Velizar T. Tchernev, Jason Christiansen, Mark Velleca and Stephen F. Kingsmore
Nature Biotechnology 20, 359–365
(April 2002); doi:10.1038/nbt0402-359
| Abstract | Full Text (HTML/PDF) |

review article
VACCINES: SPINNING MOLECULAR IMMUNOLOGY INTO SUCCESSFUL IMMUNOTHERAPY
Drew M. Pardoll
Nature Reviews Immunology 2, 227–238
(April 2002); doi:10.1038/nri774
| Abstract | Full Text (HTML/PDF) |

review article
CYTOLYTIC PATHWAYS IN HAEMATOPOIETIC STEM-CELL TRANSPLANTATION
Marcel R. M. van den Brink and Steven J. Burakoff
Nature Reviews Immunology 2, 273–281
(April 2002); doi:10.1038/nri775
| Abstract | Full Text (HTML/PDF) |

review article
NF-kB IN CANCER: FROM INNOCENT BYSTANDER TO MAJOR CULPRIT
Michael Karin, Yixue Cao, Florian R. Greten and Zhi-Wei Li
Nature Reviews Cancer 2, 301–310
(April 2002); doi:10.1038/nrc780
| Abstract | Full Text (HTML/PDF) |

news and views
Herpesvirus hijacks an integrin
Glen R. Nemerow and David A. Cheresh
Nature Cell Biology 4, E69
(April 2002); doi:10.1038/ncb0402-e69
| Full Text (HTML/PDF) |

article
Quantal release of free radicals during exocytosis of phagosomes
Anke Di, Boris Krupa, Vytas P. Bindokas, Yimei Chen, Mary E. Brown, H. Clive Palfrey, Anjaparavanda P. Naren, Kevin L. Kirk and Deborah J. Nelson
Nature Cell Biology 4, 279–285
(April 2002); doi:10.1038/ncb771
| Abstract | Full Text (HTML/PDF) |

letters to nature
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-b
Hiroshi Takayanagi, Sunhwa Kim, Koichi Matsuo, Hiroshi Suzuki, Tomohiko Suzuki, Kojiro Sato, Taeko Yokochi, Hiromi Oda, Kozo Nakamura, Nobutaka Ida, Erwin F. Wagner and Tadatsugu Taniguchi
Nature 416, 744–749
(April 2002); doi:10.1038/416744a
| First Paragraph | Full Text (HTML/PDF) |

news and views
Medicine: Interfering with bone remodelling
Tamara Alliston and Rik Derynck
Nature 416, 686–687
(April 2002); doi:10.1038/416686a
| Full Text (HTML/PDF) |

letters to nature
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki, Shinobu Suzuki, Gordon S. Duncan, Douglas G. Millar, Teiji Wada, Christine Mirtsos, Hidetoshi Takada, Andrew Wakeham, Annick Itie, Shyun Li, Josef M. Penninger, Holger Wesche, Pamela S. Ohashi, Tak W. Mak and Wen-Chen Yeh
Nature 416, 750–756
(April 2002); doi:10.1038/nature736
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news and views
Immunology: DNA drives autoimmunity
Carola G. Vinuesa and Christopher C. Goodnow
Nature 416, 595–598
(April 2002); doi:10.1038/416595a
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article
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
Elizabeth A. Leadbetter, Ian R. Rifkin, Andreas M. Hohlbaum, Britte C. Beaudette, Mark J. Shlomchik and Ann Marshak-Rothstein
Nature 416, 603–607
(April 2002); doi:10.1038/416603a
| Summary | Full Text (HTML/PDF) |

letters to nature
Protein kinase Cd controls self-antigen-induced B-cell tolerance
Ingrid Mecklenbräuker, Kaoru Saijo, Nai-Ying Zheng, Michael Leitges and Alexander Tarakhovsky
Nature 416, 860–865
(April 2002); doi:10.1038/416860a
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letters to nature
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cd
Akitomo Miyamoto, Keiko Nakayama, Hiroyuki Imaki, Sachiko Hirose, Yi Jiang, Masaaki Abe, Tadasuke Tsukiyama, Hiroyasu Nagahama, Shigeo Ohno, Shigetsugu Hatakeyama and Keiichi I. Nakayama
Nature 416, 865–869
(April 2002); doi:10.1038/416865a
| First Paragraph | Full Text (HTML/PDF) |

March

perspectives
INNOVATION: Indirect monitoring of lung inflammation
Paolo Montuschi
Nature Reviews Drug Discovery 1, 238–242
(March 2002); doi:10.1038/nrd751
| Abstract | Full Text (HTML/PDF) |

review article
THE MOLECULAR BASIS OF CaMKII FUNCTION IN SYNAPTIC AND BEHAVIOURAL MEMORY
John Lisman, Howard Schulman and Hollis Cline
Nature Reviews Neuroscience 3, 175–190
(March 2002); doi:10.1038/nrn753
| Abstract | Full Text (HTML/PDF) |

review article
CHEMOKINES: AGENTS FOR THE IMMUNOTHERAPY OF CANCER?
Bernhard Homey, Anja Müller and Albert Zlotnik
Nature Reviews Immunology 2, 175–184
(March 2002); doi:10.1038/nri748
| Abstract | Full Text (HTML/PDF) |

review article
AUTOIMMUNE THYROID DISEASE: NEW MODELS OF CELL DEATH IN AUTOIMMUNITY
Giorgio Stassi and Ruggero De Maria
Nature Reviews Immunology 2, 195–204
(March 2002); doi:10.1038/nri750
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review article
INNATE IMMUNITY: THE MISSING LINK IN NEUROPROTECTION AND NEURODEGENERATION?
Minh Dang Nguyen, Jean-Pierre Julien and Serge Rivest
Nature Reviews Neuroscience 3, 216–227
(March 2002); doi:10.1038/nrn752
| Abstract | Full Text (HTML/PDF) |

article
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Tzong-Shyuan Lee and Lee-Young Chau
Nature Medicine 8, 240–246
(March 2002); doi:10.1038/nm0302-240
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article
CD40L stabilizes arterial thrombi by a b₃ integrin-dependent mechanism
Patrick André, K.S. Srinivasa Prasad, Cécile V. Denis, Ming He, Jessie M. Papalia, Richard O. Hynes, David R. Phillips and Denisa D. Wagner
Nature Medicine 8, 247–252
(March 2002); doi:10.1038/nm0302-247
| Abstract | Full Text (HTML/PDF) |

research article
Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells
John Chester, Anja Ruchatz, Michael Gough, Marka Crittenden, Heung Chong, François Loïc-Cosset, Rosa Maria Diaz, Kevin Harrington, Luis Alvarez-Vallina and Richard Vile
Nature Biotechnology 20, 256–263
(March 2002); doi:10.1038/nbt0302-256
| Abstract | Full Text (HTML/PDF) |

letters to nature
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
Karin Reif, Eric H. Ekland, Lars Ohl, Hideki Nakano, Martin Lipp, Reinhold Förster and Jason G. Cyster
Nature 416, 94–99
(March 2002); doi:10.1038/416094a
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letters to nature
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses
Arnold I. Chin, Paul W. Dempsey, Kevin Bruhn, Jeff F. Miller, Yang Xu and Genhong Cheng
Nature 416, 190–194
(March 2002); doi:10.1038/416190a
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letters to nature
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi, Naohiro Inohara, Lorraine D. Hernandez, Jorge E. Galán, Gabriel Núñez, Charles A. Janeway, Ruslan Medzhitov and Richard A. Flavell
Nature 416, 194–199
(March 2002); doi:10.1038/416194a
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February

review article
C-TYPE LECTIN RECEPTORS ON DENDRITIC CELLS AND LANGERHANS CELLS
Carl G. Figdor, Yvette van Kooyk and Gosse J. Adema
Nature Reviews Immunology 2, 77–84
(February 2002); doi:10.1038/nri723
| Abstract | Full Text (HTML/PDF) |

review article
LIPID RAFTS AND B-CELL ACTIVATION
Susan K. Pierce
Nature Reviews Immunology 2, 96–105
(February 2002); doi:10.1038/nri726
| Abstract | Full Text (HTML/PDF) |

review article
THE B7-CD28 SUPERFAMILY
Arlene H. Sharpe and Gordon J. Freeman
Nature Reviews Immunology 2, 116–126
(February 2002); doi:10.1038/nri727
| Abstract | Full Text (HTML/PDF) |

news and views
Tumor viral escape from inhibited T cells
Raymond M. Welsh, Susan E. Stepp, Eva Szomolanyi-Tsuda and Craig D. Peacock
Nature Immunology 3, 112–114
(February 2002); doi:10.1038/ni0202-112
| Full Text (HTML/PDF) |

article
CD94-NKG2A receptors regulate antiviral CD8⁺ T cell responses
Janice M. Moser, James Gibbs, Peter E. Jensen and Aron E. Lukacher
Nature Immunology 3, 189–195
(February 2002); doi:10.1038/ni757
| Abstract |