Research library: Immunology
2003: December | November
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December
letters to nature
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
Lakshmanan Ganesh, Ezra Burstein, Anuradha Guha-Niyogi, Mark K. Louder, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett and Gary J. Nabel
Nature 426, 853–857
(18 December 2003); doi:10.1038/nature02171
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article
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Susan M Kaech, Joyce T Tan, E John Wherry, Bogumila T Konieczny, Charles D Surh and Rafi Ahmed
Nature Immunology 4, 1191–1198
(December 2003); doi:10.1038/ni1009
| Abstract | Full Text (HTML/PDF) |
article
Modulation of tryptophan catabolism by regulatory T cells
Francesca Fallarino, Ursula Grohmann, Kwang Woo Hwang, Ciriana Orabona, Carmine Vacca, Roberta Bianchi, Maria Laura Belladonna, Maria Cristina Fioretti, Maria-Luisa Alegre and Paolo Puccetti
Nature Immunology 4, 1206–1212
(December 2003); doi:10.1038/ni1003
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article
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb
Julie Dam, Rongjin Guan, Kannan Natarajan, Nazzareno Dimasi, Lukasz K Chlewicki, David M Kranz, Peter Schuck, David H Margulies and Roy A Mariuzza
Nature Immunology 4, 1213–1222
(December 2003); doi:10.1038/ni1006
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article
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
Manfred Brigl, Lynn Bry, Sally C Kent, Jenny E Gumperz and Michael B Brenner
Nature Immunology 4, 1230–1237
(December 2003); doi:10.1038/ni1002
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news and views
The NKT cell system: bridging innate and acquired immunity
Masaru Taniguchi, Ken-ichiro Seino and Toshinori Nakayama
Nature Immunology 4, 1164–1165
(December 2003); doi:10.1038/ni1203-1164
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review article
T-cell-antigen recognition and the immunological synapse
Johannes B. Huppa and Mark M. Davis
Nature Reviews Immunology 3, 973–983
(December 2003); doi:10.1038/nri1245
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review article
Dendritic-cell control of pathogen-driven T-cell polarization
Martien L. Kapsenberg
Nature Reviews Immunology 3, 984–993
(December 2003); doi:10.1038/nri1246
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letters to nature
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Joseph T. Opferman, Anthony Letai, Caroline Beard, Mia D. Sorcinelli, Christy C. Ong and Stanley J. Korsmeyer
Nature 426, 671–676
(11 December 2003); doi:10.1038/nature02067
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article
Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
James B McLachlan, Justin P Hart, Salvatore V Pizzo, Christopher P Shelburne, Herman F Staats, Michael D Gunn and Soman N Abraham
Nature Immunology 4, 1199–1205
(December 2003); doi:10.1038/ni1005
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news and views
Mast cells to the defense
Stephen J Galli and Susumu Nakae
Nature Immunology 4, 1160–1162
(December 2003); doi:10.1038/ni1203-1160
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article
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
Kasper Hoebe, Edith M Janssen, Sung O Kim, Lena Alexopoulou, Richard A Flavell, Jiahuai Han and Bruce Beutler
Nature Immunology 4, 1223–1229
(December 2003); doi:10.1038/ni1010
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news and views
Adjuvants and their signaling pathways: beyond TLRs
Egil Lien and Douglas T Golenbock
Nature Immunology 4, 1162–1164
(December 2003); doi:10.1038/ni1203-1162
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review article
Suppressors of cytokine signaling and immunity
Masato Kubo, Toshikatsu Hanada and Akihiko Yoshimura
Nature Immunology 4, 1169–1176
(December 2003); doi:10.1038/ni1012
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review article
CD28-mediated co-stimulation: a quantitative support for TCR signalling
Oreste Acuto and Frédérique Michel
Nature Reviews Immunology 3, 939–951
(December 2003); doi:10.1038/nri1248
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Taking our breath away: dendritic cells in the pathogenesis of asthma
Bart N. Lambrecht and Hamida Hammad
Nature Reviews Immunology 3, 994–1003
(December 2003); doi:10.1038/nri1249
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article
Deletion of β-catenin impairs T cell development
Youyuan Xu, Daliya Banerjee, Joerg Huelsken, Walter Birchmeier and Jyoti Misra Sen
Nature Immunology 4, 1177–1182
(December 2003); doi:10.1038/ni1008
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article
Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells
Karen W Makar, Mercedes Pérez-Melgosa, Maria Shnyreva, William M Weaver, David R Fitzpatrick and Christopher B Wilson
Nature Immunology 4, 1183–1190
(December 2003); doi:10.1038/ni1004
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article
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
Kelly D Smith, Erica Andersen-Nissen, Fumitaka Hayashi, Katie Strobe, Molly A Bergman, Sara L Rassoulian Barrett, Brad T Cookson and Alan Aderem
Nature Immunology 4, 1247–1253
(December 2003); doi:10.1038/ni1011
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news and views
TLR5 takes aim at bacterial propeller
Jean-Marc Reichhart
Nature Immunology 4, 1159–1160
(December 2003); doi:10.1038/ni1203-1159
| Full Text (HTML/PDF) |
review article
Human CD8+ T-cell differentiation in response to viruses
René A. W. van Lier, Ineke J. M. ten Berge and Laila E. Gamadia
Nature Reviews Immunology 3, 931–939
(December 2003); doi:10.1038/nri1254
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article
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo
Douglas G Millar, Kristine M Garza, Bernhard Odermatt, Alisha R Elford, Nobuyuki Ono, Zihai Li and Pamela S Ohashi
Nature Medicine 9, 1469–1476
(December 2003); doi:10.1038/nm962
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news and views
Autoimmunity heats up
Andrew E Gelman and Laurence A Turka
Nature Medicine 9, 1465–1466
(December 2003); doi:10.1038/nm1203-1465
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news and views
JAKing up immunosuppression
Megan Sykes
Nature Medicine 9, 1458–1459
(December 2003); doi:10.1038/nm1203-1458
| Full Text (HTML/PDF) |
November
letters to nature
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Wenhui Li, Michael J. Moore, Natalya Vasilieva, Jianhua Sui, Swee Kee Wong, Michael A. Berne, Mohan Somasundaran, John L. Sullivan, Katherine Luzuriaga, Thomas C. Greenough, Hyeryun Choe & Michael Farzan
Nature 426, 450–454
(27 November 2003); doi:10.1038/nature02145
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letters to nature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Takashi Nomura, Tomoyuki Tagami, Sayuri Yamazaki, Toshiko Sakihama, Takaji Matsutani, Izumi Negishi, Syuichi Nakatsuru & Shimon Sakaguchi
Nature 426, 454–460
(27 November 2003); doi:10.1038/nature02119
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article
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
Omar D Perez, Dennis Mitchell, Gina C Jager, Sharon South, Chris Murriel, Jacqueline McBride, Lee A Herzenberg, Shigemi Kinoshita and Garry P Nolan
Nature Immunology 4, 1083–1092
(November 2003); doi:10.1038/ni984
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news and views
LFA-1: more than just T cell Velcro
Yoji Shimizu
Nature Immunology 4, 1052–1054
(November 2003); doi:10.1038/ni1103-1052
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article
Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse
Richard H Clark, Jane C Stinchcombe, Anna Day, Emma Blott, Sarah Booth, Giovanna Bossi, Terry Hamblin, E Graham Davies and Gillian M Griffiths
Nature Immunology 4, 1111–1120
(November 2003); doi:10.1038/ni1000
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news and views
The latest killer AP
Margarita Del Val and Jonathan W Yewdell
Nature Immunology 4, 1049–1050
(November 2003); doi:10.1038/ni1103-1049
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article
Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development
Valérie Pouillon, Romana Hascakova-Bartova, Bernard Pajak, Emmanuelle Adam, Françoise Bex, Valérie Dewaste, Carine Van Lint, Oberdan Leo, Christophe Erneux and Stéphane Schurmans
Nature Immunology 4, 1136–1143
(November 2003); doi:10.1038/ni980
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review article
Ocular immune privilege: therapeutic opportunities from an experiment of nature
J. Wayne Streilein
Nature Reviews Immunology 3, 879–889
(November 2003); doi:10.1038/nri1224
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brief communication
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
David Engblom, Sipra Saha, Linda Engström, Marie Westman, Laurent P Audoly, Per-Johan Jakobsson and Anders Blomqvist
Nature Neuroscience 6, 1137–1138
(November 2003); doi:10.1038/nn1137
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article
The structure and binding mode of interleukin-18
Zenichiro Kato, JunGoo Jee, Hiroaki Shikano, Masaki Mishima, Izuru Ohki, Hidenori Ohnishi, Ailian Li, Kazuyuki Hashimoto, Eiji Matsukuma, Kentaro Omoya, Yutaka Yamamoto, Teruyo Yoneda, Takane Hara, Naomi Kondo & Masahiro Shirakawa
Nature Structural Biology 10, 966–971
(November 2003); doi:10.1038/nsb993
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article
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
Alberto Sánchez-Fueyo, Jane Tian, Dominic Picarella, Christoph Domenig, Xin Xiao Zheng, Catherine A. Sabatos, Natasha Manlongat, Orissa Bender, Thomas Kamradt, Vijay K. Kuchroo, José-Carlos Gutiérrez-Ramos, Anthony J. Coyle and Terry B. Strom
Nature Immunology 4, 1093–1101
(November 2003); doi:10.1038/ni987
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article
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
Catherine A Sabatos, Sumone Chakravarti, Eugene Cha, Anna Schubart, Alberto Sánchez-Fueyo, Xin Xiao Zheng, Anthony J. Coyle, Terry B. Strom, Gordon J. Freeman and Vijay K. Kuchroo
Nature Immunology 4, 1102–1110
(November 2003); doi:10.1038/ni988
| Abstract | Full Text (HTML/PDF) |
news and views
I-Tim-izing the pathways of counter-regulation
Marsha Wills-Karp, Yasmine Belkaid and Christopher L. Karp
Nature Immunology 4, 1050–1052
(November 2003); doi:10.1038/ni1103-1050
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article
Lymphotoxin pathway directs thymic Aire expression
Robert K. Chin, James C. Lo, Oliver Kim, Sarah E. Blink, Peter A. Christiansen, Pärt Peterson, Yang Wang, Carl Ware and Yang-Xin Fu
Nature Immunology 4, 1121–1127
(November 2003); doi:10.1038/ni982
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article
A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation
Dong-ming Su, Samuel Navarre, Won-jong Oh, Brian G. Condie and Nancy R. Manley
Nature Immunology 4, 1128–1135
(November 2003); doi:10.1038/ni983
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review article
Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus
Howard T. Petrie
Nature Reviews Immunology 3, 859–866
(November 2003); doi:10.1038/nri1223
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article
HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation
Mariana Marin, Kristine M. Rose, Susan L. Kozak and David Kabat
Nature Medicine 9, 1398–1403
(November 2003); doi:10.1038/nm946
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letter
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
Ann M. Sheehy, Nathan C. Gaddis and Michael H. Malim
Nature Medicine 9, 1404–1407
(November 2003); doi:10.1038/nm945
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letter
Positional cloning of a novel gene influencing asthma from Chromosome 2q14
Maxine Allen, Andrea Heinzmann, Emiko Noguchi, Gonçalo Abecasis, John Broxholme, Chris P. Ponting, Sumit Bhattacharyya, Jon Tinsley, Youming Zhang, Richard Holt, E. Yvonne Jones, Nick Lench, Alisoun Carey, Helene Jones, Nicholas J. Dickens, Claire Dimon, Rosie Nicholls, Crystal Baker, Luzheng Xue, Elizabeth Townsend, Michael Kabesch, Stephan K. Weiland, David Carr, Erika von Mutius, Ian M. Adcock, Peter J. Barnes, G. Mark Lathrop, Mark Edwards, Miriam F. Moffatt and William O. C. M. Cookson
Nature Genetics 35, 258–263
(November 2003); doi:10.1038/ng1256
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article
Targeting cytokines to inflammation sites
Gill Adams, Sandrine Vessillier, Hanna Dreja and Yuti Chernajovsky
Nature Biotechnology 21, 1314–1320
(November 2003); doi:10.1038/nbt888
| Abstract | Full Text (HTML/PDF) |
news and views
Engineering better cytokines
Lawrence Steinman
Nature Biotechnology 21, 1293–1294
(November 2003); doi:10.1038/nbt1103-1293
| Abstract | Full Text (HTML/PDF) |
article
Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain
Gregory Lizée, Genc Basha, Jacqueline Tiong, Jean-Pierre Julien, Meimei Tian, Kaan E Biron and Wilfred A Jefferies
Nature Immunology 4, 1065–1073
(November 2003); doi:10.1038/ni989
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news and views
Y in X priming
Sebastian Amigorena
Nature Immunology 4, 1047–1048
(November 2003); doi:10.1038/ni1103-1047
| Full Text (HTML/PDF) |
review article
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
Jesse E Jun and Christopher C Goodnow
Nature Immunology 4, 1057–1064
(November 2003); doi:10.1038/ni1001
| Abstract | Full Text (HTML/PDF) |
article
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Jayakrishna Ambati, Akshay Anand, Stefan Fernandez, Eiji Sakurai, Bert C Lynn, William A Kuziel, Barrett J Rollins and Balamurali K Ambati
Nature Medicine 9, 1390–1397
(November 2003); doi:10.1038/nm950
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news and views
Macrophages eyed in macular degeneration
J V Forrester
Nature Medicine 9, 1350–1351
(November 2003); doi:10.1038/nm1103-1350
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article
A genetic approach to inactivating chemokine receptors using a modified viral protein
V McNeil Coffield, Qi Jiang & Lishan Su
Nature Biotechnology 21,1321–1327
( 2000); doi:10.1038/nbt889
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article
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
Bin Y Qin, Cheng Liu, Suvana S Lam, Hema Srinath, Rachel Delston, John J Correia, Rik Derynck and Kai Lin
Nature Structural Biology 10, 913–921
(November 2003); doi:10.1038/nsb1002
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article
X-ray crystal structure of IRF-3 and its functional implications
Kiyohiro Takahasi, Nobuo N Suzuki, Masataka Horiuchi, Mitsuaki Mori, Wakako Suhara, Yasutaka Okabe, Yukiko Fukuhara, Hiroaki Terasawa, Shizuo Akira, Takashi Fujita and Fuyuhiko Inagaki
Nature Structural Biology 10, 922–927
(November 2003); doi:10.1038/nsb1001
| Abstract | Full Text (HTML/PDF) |
news and views
The nuts and bolts of IRF structure
Aristidis Moustakas and Carl-Henrik Heldin
Nature Structural Biology 10, 874–876
(November 2003); doi:10.1038/nsb1103-874
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review article
The immune response of Drosophila
Jules A. Hoffmann
Nature 426, 33–38
(06 November 2003); doi:10.1038/nature02021
| Abstract | Full Text (HTML / PDF) |
article
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda and Shizuo Akira
Nature Immunology 4, 1144–1150
(November 2003); doi:10.1038/ni986
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article
Enhancement of CIITA transcriptional function by ubiquitin
Susanna F Greer, Eleni Zika, Brian Conti, Xin-Sheng Zhu and Jenny P-Y Ting
Nature Immunology 4, 1074–1082
(November 2003); doi:10.1038/ni985
| Abstract | Full Text (HTML/PDF) |
review article
Regulation of JAK-STAT signalling in the immune system
Ke Shuai and Bin Liu
Nature Reviews Immunology 3, 900–911
(November 2003); doi:10.1038/nri1226
| Summary | Full Text (HTML / PDF) |
October
letters to nature
Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion
Marco Prinz , Mathias Heikenwalder, Tobias Junt, Petra Schwarz, Markus Glatzel, Frank L. Heppner, Yang-Xin Fu, Martin Lipp and Adriano Aguzzi
Nature 425, 957–962
(30 October 2003); doi:10.1038/nature02072
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article
LAT regulates γd T cell homeostasis and differentiation
Selene Nuñez-Cruz, Enrique Aguado, Sylvie Richelme, Bruno Chetaille, Anne-Marie Mura, Mireille Richelme, Laurent Pouyet, Evelyne Jouvin-Marche, Luc Xerri, Bernard Malissen and Marie Malissen
Nature Immunology 4, 999–1008
(October 2003); doi:10.1038/ni977
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article
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor
Richard Dahl, Jonathan C Walsh, David Lancki, Peter Laslo, Sangeeta R Iyer, Harinder Singh and M Celeste Simon
Nature Immunology 4, 1029–1036
(October 2003); doi:10.1038/ni973
| Abstract | Full Text (HTML/PDF) |
review article
Macrophage migration inhibitory factor: a regulator of innate immunity
Thierry Calandra and Thierry Roger
Nature Reviews Immunology 3, 791–800
(October 2003); doi:10.1038/nri1200
| Abstract | Full Text (HTML / PDF) |
review article
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
Pablo Engel, Michael J. Eck and Cox Terhorst
Nature Reviews Immunology 3, 813–821
(October 2003); doi:10.1038/nri1202
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article
Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
Nicola J Monk, Roseanna E G Hargreaves, James E Marsh, Conrad A Farrar, Steven H Sacks, Maggie Millrain, Elizabeth Simpson, Julian Dyson and Stipo Jurcevic
Nature Medicine 9, 1275–1280
(October 2003); doi:10.1038/nm931
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news and views
The new immunosuppression: just kill the T cell
Herman Waldmann
Nature Medicine 9, 1259–1260
(October 2003); doi:10.1038/nm1003-1259
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article
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses
Simona Stäger, James Alexander, Alun C Kirby, Marina Botto, Nico Van Rooijen, Deborah F Smith, Frank Brombacher and Paul M Kaye
Nature Medicine 9, 1287–1292
(October 2003); doi:10.1038/nm933
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letter
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
Judson A Brewer, Bernard Khor, Sherri K Vogt, Lisa M Muglia, Hideji Fujiwara, Karen E Haegele, Barry P Sleckman and Louis J Muglia
Nature Medicine 9, 1318–1322
(October 2003); doi:10.1038/nm895
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article
Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element
Michael J Giffin, James C Stroud, Darren L Bates, Konstanze D von Koenig, John Hardin and Lin Chen
Nature Structural Biology 10, 800–806
(October 2003); doi:10.1038/nsb981
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article
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
Katayoon Goodarzi, Mahmoud Goodarzi, Andrew M Tager, Andrew D Luster and Ulrich H von Andrian
Nature Immunology 4, 965–973
(October 2003); doi:10.1038/ni972
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article
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4
Vanessa L Ott, John C Cambier, John Kappler, Philippa Marrack & Bradley J Swanson
Nature Immunology 4,974–981
( 2000); doi:10.1038/ni971
| Abstract
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article
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
Andrew M Tager, Shannon K Bromley, Benjamin D Medoff, Sabina A Islam, Scott D Bercury, Erik B Friedrich, Andrew D Carafone, Robert E Gerszten and Andrew D Luster
Nature Immunology 4, 982–990
(October 2003); doi:10.1038/ni970
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news and views
BLT for speed
Stephen P Schoenberger
Nature Immunology 4, 937–939
(October 2003); doi:10.1038/ni1003-937
| | Full Text (HTML/PDF) |
article
An asymmetric NFAT1 dimer on a pseudo-palindromic kB-like DNA site
Lei Jin, Piotr Sliz, Lin Chen, Fernando Macián, Anjana Rao, Patrick G Hogan and Stephen C Harrison
Nature Structural Biology 10, 807–811
(October 2003); doi:10.1038/nsb975
| Abstract | Full Text (HTML/PDF) |
article
Sustained exposure to bacterial antigen induces interferon-γ-dependent T cell receptor ζ down-regulation and impaired T cell function
Noemí Bronstein-Sitton, Leonor Cohen-Daniel, Ilan Vaknin, Analía V Ezernitchi, Benny Leshem, Amal Halabi, Yael Houri-Hadad, Eugenia Greenbaum, Zichria Zakay-Rones, Lior Shapira and Michal Baniyash
Nature Immunology 4, 957–964
(October 2003); doi:10.1038/ni975
| Abstract | Full Text (HTML/PDF) |
news and views
Unplugging the T cell receptor
Guido Poli and Claudio Bordignon
Nature Immunology 4, 943–944
(October 2003); doi:10.1038/ni1003-943
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article
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
Agnes Le Bon, Nathalie Etchart, Cornelia Rossmann, Miranda Ashton, Sam Hou, Dirk Gewert, Persephone Borrow and David F Tough
Nature Immunology 4, 1009–1015
(October 2003); doi:10.1038/ni978
| Abstract | Full Text (HTML/PDF) |
news and views
Type I interferons promote cross-priming: more functions for old cytokines
Anne-Sophie Beignon, Mojca Skoberne and Nina Bhardwaj
Nature Immunology 4, 939–941
(October 2003); doi:10.1038/ni1003-939
| Full Text (HTML/PDF) |
review article
Plasma-cell homing
Eric J. Kunkel and Eugene C. Butcher
Nature Reviews Immunology 3, 822–829
(October 2003); doi:10.1038/nri1203
| Abstract | Full Text (HTML / PDF) |
letters to nature
Molecular identification of a danger signal that alerts the immune system to dying cells
Yan Shi, James E. Evans and Kenneth L. Rock
Nature 425, 516–521
(02 October 2003); doi:10.1038/nature01991
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Dangerous liaisons
William R. Heath and Francis R. Carbone
Nature 425, 460–461
(02 October 2003); doi:10.1038/425460a
| Full Text (HTML / PDF) |
article
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
Minna Woo, Razqallah Hakem, Caren Furlonger, Anne Hakem, Gordon S. Duncan, Takehiko Sasaki, Denis Bouchard, Liwei Lu, Gillian E. Wu, Christopher J. Paige and Tak W. Mak
Nature Immunology 4, 1016–1022
(October 2003); doi:10.1038/ni976
| Abstract | Full Text (HTML/PDF) |
news and views
The ins and outs of cross-presentation
Kenneth L. Rock
Nature Immunology 4, 941–943
(October 2003); doi:10.1038/ni1003-941
| Full Text (HTML/PDF) |
perspectives
Timeline: Individuality: the barrier to optimal immunosuppression
Barry D. Kahan
Nature Reviews Immunology 3, 831–838
(October 2003); doi:10.1038/nri1204
| Abstract | Full Text (HTML / PDF) |
article
Differential requirement for CD18 in T-helper effector homing
Seung-Hyo Lee, Joseph E. Prince, Muhammad Rais, Farrah Kheradmand, Felix Shardonofsky, Huifang Lu, Arthur L. Beaudet, C. Wayne Smith, Lynn Soong and David B. Corry
Nature Medicine 9, 1281–1286
(October 2003); doi:10.1038/nm932
| Abstract | Full Text (HTML/PDF) |
September
letters to nature
ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells
Pierre Guermonprez, Loredana Saveanu, Monique Kleijmeer, Jean Davoust, Peter van Endert and Sebastian Amigorena
Nature 425, 397–402
(25 September 2003); doi:10.1038/nature01911
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letters to nature
Phagosomes are competent organelles for antigen cross-presentation
Mathieu Houde, Sylvie Bertholet, Etienne Gagnon, Sylvain Brunet, Guillaume Goyette, Annie Laplante, Michael F. Princiotta, Pierre Thibault, David Sacks and Michel Desjardins
Nature 425, 402–406
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Immunology: Professional secrets
Craig R. Roy
Nature 425, 351–352
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Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria
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Nature Cell Biology 5, 793–802
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Phagosomes, fatty acids and tuberculosis
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Nature Cell Biology 5, 776–778
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Nature Reviews Molecular Cell Biology 4, 721–732
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SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
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Nature Immunology 4, 920–927
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SIGIRR puts the brakes on Toll-like receptors
Luke A. J. O'Neill
Nature Immunology 4, 823–824
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Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
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Nature Immunology 4, 857–865
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Nature Immunology 4, 835–842
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The regulation of immunoglobulin E class-switch recombination
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Nature Reviews Immunology 3, 721–732
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Anti-TNF-α therapies: the next generation
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Nature Reviews Drug Discovery 2, 736–746
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The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin
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Nature Immunology 4, 874–881
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Calcium-independent calcineurin regulation
Richard V. Parry and Carl H. June
Nature Immunology 4, 821–823
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CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions
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Nature Immunology 4, 891–898
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ComPLEXIN new targets for CIITA
Walter Reith
Nature Immunology 4, 819–820
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Are follicular dendritic cells really good for nothing?
Marie H. Kosco-Vilbois
Nature Reviews Immunology 3, 764–769
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Activation of the interferon system by short-interfering RNAs
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Nature Cell Biology 5, 834–839
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Small-interfering RNAs in the radar of the interferon system
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Nature Cell Biology 5, 771–772
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The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling
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Nature Immunology 4, 849–856
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How pre-B cells know when they have it right
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Nature Immunology 4, 817–819
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Nature Reviews Immunology 3, 745–756
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TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
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Nature Medicine 9, 1202–1208
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Enhanced T cell responses due to diacylglycerol kinase ζ deficiency
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Nature Immunology 4, 882–890
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Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor
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Nature Immunology 4, 913–919
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Boosting p53 with interferon and viruses
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Nature Immunology 4, 825–826
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DC-SIGN: escape mechanism for pathogens
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The sirens' call
Valerie A. Fadok
Nature Cell Biology 5, 697–699
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The influence of the thymic environment on the CD4-versus-CD8 T lineage decision
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Nature Immunology 4, 756–764
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Deadbeat neighbors influence thymocyte lineage commitment
Pamela J. Fink
Nature Immunology 4, 727–728
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Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors
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Nature Immunology 4, 801–807
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SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
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Nature Medicine 9, 1047–1054
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Anthrax delivers a lethal blow to host immunity
Michael N. Starnbach and R. John Collier
Nature Medicine 9, 996–997
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Contribution of BCAP to maintenance of mature B cells through c-Rel
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Nature Immunology 4, 780–786
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Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development
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Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster
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Nature Immunology 4, 787–793
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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
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Immunology: Another toll road
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Nature 424, 736–737
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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
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Nature Immunology 4, 741–748
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Rap1 redux
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Nature Immunology 4, 725–727
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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
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Nature Reviews Immunology 3, 609–620
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Dendritic cells, engineered to secrete a T-cell receptor mimic peptide, induce antigen-specific immunosuppression in vivo
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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
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Toll gets tied in a knot
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Nature Immunology 4, 723–724
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Class II cytokine receptors and their ligands: Key antiviral and inflammatory modulators
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Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence
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Continuous T cell receptor signaling required for synapse maintenance and full effector potential
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Nature Immunology 4, 749–755
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Nefarious abuse
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Nature Immunology 4, 729–730
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Neurobiology: A new way to network
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CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
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Nature Immunology 4, 687–693
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T-bet: The Toll-bridge to class-switch recombination?
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Pathogens: raft hijackers
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Nature Reviews Immunology 3, 557–568
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Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
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Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin
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Nature 424, 329–334
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The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens
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Nature Immunology 4, 664–669
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Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
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Nature Immunology 4, 680–686
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Three or more routes for leukocyte migration into the central nervous system
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Nature Reviews Immunology 3, 569–581
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Regulation of IL4 gene expression by T cells and therapeutic perspectives
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Nature Reviews Immunology 3, 534–543
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CpG motifs: the active ingredient in bacterial extracts?
Arthur M Krieg
Nature Medicine 9, 831–835
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HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
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Nature 424, 213–219
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HIV: Cross-talk and viral reservoirs
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Nature Immunology 4, 649–650
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The immunological and genetic basis of inflammatory bowel disease
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Nature Reviews Immunology 3, 521–533
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Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
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More negative feedback?
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Nature Immunology 4, 647–648
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An epigenetic view of helper T cell differentiation
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Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
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Bcl11a is essential for normal lymphoid development
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Bcl11b is required for differentiation and survival of αβ T lymphocytes
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Bcl11: sibling rivalry in lymphoid development
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The TIM gene family: emerging roles in immunity and disease
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Therapeutic strategies for rheumatoid arthritis
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NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway
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NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
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Nature Immunology 4, 565–572
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The choices of a natural killer
Giorgio Trinchieri
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Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
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Nature Medicine 9, 744–749
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Subversion of the innate immune system by a retrovirus
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Nature Immunology 4, 573–578
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E-proteins directly regulate expression of activation-induced deaminase in mature B cells
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Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
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Nature Immunology 4, 594–600
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A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects
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Nature Medicine 9, 750–755
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Biological drug duo delivers one-two tumor punch
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Insights into IgA-mediated immune responses from the crystal structures of human FcαRI and its complex with IgA1-Fc
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Nature 423, 614–620
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SOCS3 negatively regulates IL-6 signaling in vivo
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Nature Immunology 4, 540–545
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SOCS3 regulates the plasticity of gp130 signaling
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Nature Immunology 4, 546–550
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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
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Nature Immunology 4, 551–556
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Matching SOCS with function
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Nature Immunology 4, 507–509
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TREMs in the immune system and beyond
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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
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Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
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Nature Immunology 4, 485–490
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Caspase-independent cell death in T lymphocytes
Marja Jäättelä and Jürg Tschopp
Nature Immunology 4, 416–423
(May 2003); doi:10.1038/ni0503-416
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review article
What does it take to make a natural killer?
Francesco Colucci, Michael A. Caligiuri and James P. Di Santo
Nature Reviews Immunology 3, 413–425
(May 2003); doi:10.1038/nri1088
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Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
Joseph N. Blattman, Jason M. Grayson, E. John Wherry, Susan M. Kaech, Kendall A. Smith and Rafi Ahmed
Nature Medicine 9, 540–547
(May 2003); doi:10.1038/nm866
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news and views
Mastering innate immunity
Robert M. Strieter
Nature Medicine 9, 512–513
(May 2003); doi:10.1038/nm0503-512
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review article
Such stuff as dreams are made on: mediator-directed therapy in sepsis
John C. Marshall
Nature Reviews Drug Discovery 2, 391–405
(May 2003); doi:10.1038/nrd1084
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The Drosophila immune system detects bacteria through specific peptidoglycan recognition
François Leulier, Claudine Parquet, Sebastien Pili-Floury, Ji-Hwan Ryu, Martine Caroff, Won-Jae Lee, Dominique Mengin-Lecreulx and Bruno Lemaitre
Nature Immunology 4, 478–484
(May 2003); doi:10.1038/ni922
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review article
Apoptosis in the development and maintenance of the immune system
Joseph T. Opferman and Stanley J. Korsmeyer
Nature Immunology 4, 410–415
(May 2003); doi:10.1038/ni0503-410
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review article
Apoptosis as an HIV strategy to escape immune attack
Marie-Lise Gougeon
Nature Reviews Immunology 3, 392–404
(May 2003); doi:10.1038/nri1087
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review article
Caenorhabditis elegans: an emerging genetic model for the study of innate immunity
C. Léopold Kurz and Jonathan J. Ewbank
Nature Reviews Genetics 4, 380–390
(May 2003); doi:10.1038/nrg1067
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review
Evolving concepts of rheumatoid arthritis
Gary S. Firestein
Nature 423, 356–361
(15 May 2003); doi:10.1038/nature01661
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review article
Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens
Carrie M. Rosenberger and B. Brett Finlay
Nature Reviews Molecular Cell Biology 4, 385–396
(May 2003); doi:10.1038/nrm1104
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Monoallelic expression of the murine gene encoding Toll-like receptor 4
João Pedro Pereira, Robert Girard, Richard Chaby, Ana Cumano and Paulo Vieira
Nature Immunology 4, 464–470
(May 2003); doi:10.1038/ni917
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review article
The death effector domain protein family: regulators of cellular homeostasis
Michael D. Tibbetts, Lixin Zheng and Michael J. Lenardo
Nature Immunology 4, 404–409
(May 2003); doi:10.1038/ni0503-404
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review article
Negative selection — clearing out the bad apples from the T-cell repertoire
Ed Palmer
Nature Reviews Immunology 3, 383–391
(May 2003); doi:10.1038/nri1085
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Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
Marina Karaghiosoff, Ralf Steinborn, Pavel Kovarik, Gernot Kriegshäuser, Manuela Baccarini, Birgit Donabauer, Ursula Reichart, Thomas Kolbe, Christian Bogdan, Tomas Leanderson, David Levy, Thomas Decker and Mathias Müller
Nature Immunology 4, 471–477
(May 2003); doi:10.1038/ni910
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news and views
CD8 and B cell memory: same strategy, same signals
Corinne Tanchot and Benedita Rocha
Nature Immunology 4, 431–432
(May 2003); doi:10.1038/ni0503-431
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review article
NODs: intracellular proteins involved in inflammation and apoptosis
Naohiro Inohara and Gabriel Nuñez
Nature Reviews Immunology 3, 371–382
(May 2003); doi:10.1038/nri1086
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perspectives
Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity
Christopher V. Nicchitta
Nature Reviews Immunology 3, 427–432
(May 2003); doi:10.1038/nri1089
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Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
Stephan R. Krutzik, Maria Teresa Ochoa, Peter A. Sieling, Satoshi Uematsu, Yolanda W. Ng, Annaliza Legaspi, Philip T. Liu, Stewart T. Cole, Paul J. Godowski, Yumi Maeda, Euzenir N. Sarno, Michael V. Norgard, Patrick J. Brennan, Shizuo Akira, Thomas H. Rea and Robert L. Modlin
Nature Medicine 9, 525–532
(May 2003); doi:10.1038/nm864
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IKK and TBK1 are essential components of the IRF3 signaling pathway
Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia, Daniel C. Rowe, Eicke Latz, Douglas T. Golenbock, Anthony J. Coyle, Sha-Mei Liao and Tom Maniatis
Nature Immunology 4, 491–496
(May 2003); doi:10.1038/ni921
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news and views
Linking Toll-like receptors to IFN-a/b expression
Gregory M. Barton and Ruslan Medzhitov
Nature Immunology 4, 432–433
(May 2003); doi:10.1038/ni0503-432
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review article
Cell death and immunity: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
Judy Lieberman
Nature Reviews Immunology 3, 361–370
(May 2003); doi:10.1038/nri1083
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Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Omid Akbari, Philippe Stock, Everett Meyer, Mitchell Kronenberg, Stephane Sidobre, Toshinori Nakayama, Masaru Taniguchi, Michael J. Grusby, Rosemarie H. DeKruyff and Dale T. Umetsu
Nature Medicine 9, 582–588
(May 2003); doi:10.1038/nm851
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letter
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
Paolo A. Hernandez, Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman and George A. Diaz
Nature Genetics 34, 70–74
(May 2003); doi:10.1038/ng1149
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April
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Jason D. Fontenot, Marc A. Gavin and Alexander Y. Rudensky
Nature Immunology 4, 330–336
(April 2003); doi:10.1038/ni904
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An essential role for Scurfin in CD4+CD25+ T regulatory cells
Roli Khattri, Tom Cox, Sue-Ann Yasayko and Fred Ramsdell
Nature Immunology 4, 337–342
(April 2003); doi:10.1038/ni909
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news and views
Twenty-first century Foxp3
Anne O'Garra and Paulo Vieira
Nature Immunology 4, 304–306
(April 2003); doi:10.1038/ni0403-304
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review article
Cytokine control of memory T-cell development and survival
Kimberly S. Schluns and Leo Lefrançois
Nature Reviews Immunology 3, 269–279
(April 2003); doi:10.1038/nri1052
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review article
Immune functions encoded by the natural killer gene complex
Wayne M. Yokoyama and Beatrice F. M. Plougastel
Nature Reviews Immunology 3, 304–316
(April 2003); doi:10.1038/nri1055
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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
Neal N. Iwakoshi, Ann-Hwee Lee, Prasanth Vallabhajosyula, Kevin L. Otipoby, Klaus Rajewsky and Laurie H. Glimcher
Nature Immunology 4, 321–329
(April 2003); doi:10.1038/ni907
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news and views
The stressful road to antibody secretion
Yanjun Ma and Linda M. Hendershot
Nature Immunology 4, 310–311
(April 2003); doi:10.1038/ni0403-310
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review article
The role of PI3K in immune cells
Shigeo Koyasu
Nature Immunology 4, 313–319
(April 2003); doi:10.1038/ni0403-313
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review article
ER-mediated phagocytosis: a new membrane for new functions
Michel Desjardins
Nature Reviews Immunology 3, 280–291
(April 2003); doi:10.1038/nri1053
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article
F(ab)′2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins
Milan Basta, Fredric Van Goor, Stefano Luccioli, Eric M. Billings, Alexander O. Vortmeyer, Lajos Baranyi, Janos Szebeni, Carl R. Alving, Michael C. Carroll, Ira Berkower, Stanko S. Stojilkovic and Dean D. Metcalfe
Nature Medicine 9, 431–438
(April 2003); doi:10.1038/nm836
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SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates
Hongyan Wang, Eun-Yi Moon, Abdallah Azouz, Xiang Wu, Andrew Smith, Helga Schneider, Nancy Hogg and Christopher E. Rudd
Nature Immunology 4, 366–374
(April 2003); doi:10.1038/ni913
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Transcriptional profiling identifies Id2 function in dendritic cell development
Christine Hacker, Ralf D. Kirsch, Xin-Sheng Ju, Thomas Hieronymus, Tatjana C. Gust, Christiane Kuhl, Thorsten Jorgas, Steffen M. Kurz, Stefan Rose-John, Yoshifumi Yokota and Martin Zenke
Nature Immunology 4, 380–386
(April 2003); doi:10.1038/ni903
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review article
PI3K in lymphocyte development, differentiation and activation
Klaus Okkenhaug and Bart Vanhaesebroeck
Nature Reviews Immunology 3, 317–330
(April 2003); doi:10.1038/nri1056
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Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
Anje Cauwels, Ben Janssen, Anouk Waeytens, Claude Cuvelier and Peter Brouckaert
Nature Immunology 4, 387–393
(April 2003); doi:10.1038/ni914
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news and views
Caspase activation is not death
Jean-Luc Perfettini and Guido Kroemer
Nature Immunology 4, 308–310
(April 2003); doi:10.1038/ni0403-308
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review article
Organogenesis of lymphoid tissues
Reina E. Mebius
Nature Reviews Immunology 3, 292–303
(April 2003); doi:10.1038/nri1054
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March
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PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W. Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki and Shigeo Koyasu
Nature Immunology 4, 280–286
(March 2003); doi:10.1038/ni890
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Lineage relationship and protective immunity of memory CD8 T cell subsets
E. John Wherry, Volker Teichgräber, Todd C. Becker, David Masopust, Susan M. Kaech, Rustom Antia, Ulrich H. von Andrian and Rafi Ahmed
Nature Immunology 4, 225–234
(March 2003); doi:10.1038/ni889
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news and views
Memory lanes
Vladimir P. Badovinac and John T. Harty
Nature Immunology 4, 212–213
(March 2003); doi:10.1038/ni0303-212
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Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
Amy N. Anzelon, Hong Wu and Robert C. Rickert
Nature Immunology 4, 287–294
(March 2003); doi:10.1038/ni892
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review article
Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity
S. Brian Wilson and Terry L. Delovitch
Nature Reviews Immunology 3, 211–222
(March 2003); doi:10.1038/nri1028
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article
Angiogenins: a new class of microbicidal proteins involved in innate immunity
Lora V. Hooper, Thaddeus S. Stappenbeck, Chieu V. Hong and Jeffrey I. Gordon
Nature Immunology 4, 269–273
(March 2003); doi:10.1038/ni888
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news and views
Angiogenin: an antimicrobial ribonuclease
Tomas Ganz
Nature Immunology 4, 213–214
(March 2003); doi:10.1038/ni0303-213
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review article
The nature of molecular recognition by T cells
Simon J. Davis, Shinji Ikemizu, Edward J. Evans, Lars Fugger, Talitha R. Bakker and P. Anton van der Merwe
Nature Immunology 4, 217–224
(March 2003); doi:10.1038/ni0303-217
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perspectives
Natural versus adaptive regulatory T cells
Jeffrey A. Bluestone and Abul K. Abbas
Nature Reviews Immunology 3, 253–257
(March 2003); doi:10.1038/nri1032
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article
Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system
Shirley Shidu Yan, Zhi-Ying Wu, Hui Ping Zhang, Glaucia Furtado, Xi Chen, Shi Fang Yan, Ann Marie Schmidt, Chris Brown, Alan Stern, Juan Lafaille, Leonard Chess, David M. Stern and Hong Jiang
Nature Medicine 9, 287–293
(March 2003); doi:10.1038/nm831
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article
Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice
Salah-Eddine Lamhamedi-Cherradi, Shi-Jun Zheng, Kimberly A. Maguschak, Jacques Peschon and Youhai H. Chen
Nature Immunology 4, 255–260
(March 2003); doi:10.1038/ni894
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news and views
The suicide in the thymus, a twisted trail
Douglas R. Green
Nature Immunology 4, 207–208
(March 2003); doi:10.1038/ni0303-207
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Immunology: Fast and feel good?
Vijay K. Kuchroo and Lindsay B. Nicholson
Nature 422, 27–28
(06 March 2003); doi:10.1038/422027a
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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Irena Štefanová, Bernhard Hemmer, Marco Vergelli, Roland Martin, William E. Biddison and Ronald N. Germain
Nature Immunology 4, 248–254
(March 2003); doi:10.1038/ni895
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Tuning the immune system: competing positive and negative feedback loops
Daniel L. Mueller
Nature Immunology 4, 210–211
(March 2003); doi:10.1038/ni0303-210
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Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development
Kaoru Saijo, Christian Schmedt, I-hsin Su, Hajime Karasuyama, Clifford A. Lowell, Michael Reth, Takahiro Adachi, Alina Patke, Angela Santana and Alexander Tarakhovsky
Nature Immunology 4, 274–279
(March 2003); doi:10.1038/ni893
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Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
Jie Fan and Asrar B. Malik
Nature Medicine 9, 315–321
(March 2003); doi:10.1038/nm832
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February
letter
SAP couples Fyn to SLAM immune receptors
Betty Chan, Arpad Lanyi, Hyun Kyu Song, Jan Griesbach, Maria Simarro-Grande, Florence Poy, Duncan Howie, Janos Sumegi, Cox Terhorst and Michael J. Eck
Nature Cell Biology 5, 155–160
(February 2003); doi:10.1038/ncb920
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article
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
Claudine Irles, Antony Symons, Frédérique Michel, Talitha R. Bakker, P. Anton van der Merwe and Oreste Acuto
Nature Immunology 4, 189–197
(February 2003); doi:10.1038/ni877
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review article
CD3-specific antibody-induced active tolerance: from bench to bedside
Lucienne Chatenoud
Nature Reviews Immunology 3, 123–132
(February 2003); doi:10.1038/nri1000
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perspectives
Timeline: Innate immune sensing and its roots: the story of endotoxin
Bruce Beutler and Ernst Th. Rietschel
Nature Reviews Immunology 3, 169–176
(February 2003); doi:10.1038/nri1004
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Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells
Jeong-Hyeon Sohn, Puran S. Bora, Hye-Jung Suk, Hector Molina, Henry J. Kaplan and Nalini S. Bora
Nature Medicine 9, 206–212
(February 2003); doi:10.1038/nm814
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news and views
B cell memory: Sapping the T cell
Raymond M. Welsh, Susan E. Stepp and Eva Szomolanyi-Tsuda
Nature Medicine 9, 164–166
(February 2003); doi:10.1038/nm0203-164
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letters to nature
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Edith M. Janssen, Edward E. Lemmens, Tom Wolfe, Urs Christen, Matthias G. von Herrath and Stephen P. Schoenberger
Nature 421, 852–856
(20 February 2003); doi:10.1038/nature01441
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article
Thymopoiesis independent of common lymphoid progenitors
David Allman, Arivazhagan Sambandam, Sungjune Kim, Juli P. Miller, Antonio Pagan, David Well, Anita Meraz and Avinash Bhandoola
Nature Immunology 4, 168–174
(February 2003); doi:10.1038/ni878
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news and views
To T or not to T: reassessing the common lymphoid progenitor
Encarnacion Montecino-Rodriguez and Kenneth Dorshkind
Nature Immunology 4, 100–101
(February 2003); doi:10.1038/ni0203-100
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Functional interactions between dendritic cells and NK cells during viral infection
Daniel M. Andrews, Anthony A. Scalzo, Wayne M. Yokoyama, Mark J. Smyth and Mariapia A. Degli-Esposti
Nature Immunology 4, 175–181
(February 2003); doi:10.1038/ni880
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review article
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
B. Matija Peterlin and Didier Trono
Nature Reviews Immunology 3, 97–107
(February 2003); doi:10.1038/nri998
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HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages
Elena Izmailova, Frederic M.N. Bertley, Qian Huang, Norbert Makori, Christopher J. Miller, Richard A. Young and Anna Aldovini
Nature Medicine 9, 191–197
(February 2003); doi:10.1038/nm822
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news and views
Tat's seductive side
Mario Stevenson
Nature Medicine 9, 163–164
(February 2003); doi:10.1038/nm0203-163
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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
Sean B. Joseph, Antonio Castrillo, Bryan A. Laffitte, David J. Mangelsdorf and Peter Tontonoz
Nature Medicine 9, 213–219
(February 2003); doi:10.1038/nm820
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eLiXiRs for restraining inflammation
Mason W. Freeman and Kathryn J. Moore
Nature Medicine 9, 168–169
(February 2003); doi:10.1038/nm0203-168
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