Research library: Immunology
2004: December
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December
letters to nature
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
Antonio Iavarone , Emerson R. King, Xu-Ming Dai, Gustavo Leone, E. Richard Stanley and Anna Lasorella
Nature 432, 1040–1045
(23 December 2004); doi:10.1038/nature03068
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news and views
Developmental biology: No red cell is an island
James Palis
Nature 432, 964–965
(23 December 2004); doi:10.1038/432964a
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article
Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
Stéphanie Hugues, Luc Fetler, Laura Bonifaz, Julie Helft, François Amblard and Sebastian Amigorena
Nature Immunology 5, 1235–1242
(December 2004); doi:10.1038/ni1134
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article
Visualizing dendritic cell networks in vivo
Randall L Lindquist, Guy Shakhar, Diana Dudziak, Hedda Wardemann, Thomas Eisenreich, Michael L Dustin and Michel C Nussenzweig
Nature Immunology 5, 1243–1250
(December 2004); doi:10.1038/ni1139
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news and views
Lead and follow: the dance of the dendritic cell and T cell
Antonio Lanzavecchia and Federica Sallusto
Nature Immunology 5, 1201–1202
(December 2004); doi:10.1038/ni1204-1201
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review article
A BAF-centred view of the immune system
Tian Chi
Nature Reviews Immunology 4, 965–977
(December 2004); doi:10.1038/nri1501
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letter
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection
Kenneth J Ritchie, Chang S Hahn, Keun Il Kim, Ming Yan, Dabralee Rosario, Li Li, Juan Carlos de la Torre and Dong-Er Zhang
Nature Medicine 10, 1374–1378
(December 2004); doi:10.1038/nm1133
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news and views
Vitamin A helps gut T cells find their way in the dark
Bengt Johansson-Lindbom and William W Agace
Nature Medicine 10, 1300–1301
(December 2004); doi:10.1038/nm1204-1300
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news and views
PTPN22 and autoimmune disease
Katherine A Siminovitch
Nature Genetics 36, 1248–1249
(December 2004); doi:10.1038/ng1204-1248
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letters to nature
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Trude H. Flo , Kelly D. Smith , Shintaro Sato, David J. Rodriguez, Margaret A. Holmes, Roland K. Strong, Shizuo Akira and Alan Aderem
Nature 432, 917–921
(16 December 2004); doi:10.1038/nature03104
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news and views
Cell biology: Iron thievery
Jonathan Barasch and Kiyoshi Mori
Nature 432, 811–813
(16 December 2004); doi:10.1038/432811a
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article
Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection
Elina I Zuniga, Dorian B McGavern, Jose L Pruneda-Paz, Chao Teng and Michael B A Oldstone
Nature Immunology 5, 1227–1234
(December 2004); doi:10.1038/ni1136
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news and views
Are dendritic cells afraid of commitment?
Anne O'Garra and Giorgio Trinchieri
Nature Immunology 5, 1206–1208
(December 2004); doi:10.1038/ni1204-1206
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review article
Plasmacytoid dendritic cells in immunity
Marco Colonna, Giorgio Trinchieri and Yong-Jun Liu
Nature Immunology 5, 1219–1226
(December 2004); doi:10.1038/ni1141
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review article
War and peace at mucosal surfaces
Philippe J. Sansonetti
Nature Reviews Immunology 4, 953–964
(December 2004); doi:10.1038/nri1499
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research article
Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity
Lei Shen, Kevin Evel-Kabler, Randy Strube and Si-Yi Chen
Nature Biotechnology 22, 1546–1553
(December 2004); doi:10.1038/nbt1035
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article
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
K Mark Ansel, Rebecca J Greenwald, Suneet Agarwal, Craig H Bassing, Silvia Monticelli, Jeneen Interlandi, Ivana M Djuretic, Dong U Lee, Arlene H Sharpe, Frederick W Alt and Anjana Rao
Nature Immunology 5, 1251–1259
(December 2004); doi:10.1038/ni1135
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hypothesis
Labeled antigens and antibodies: the evolution of magic markers and magic bullets
Arthur M Silverstein
Nature Immunology 5, 1211–1217
(December 2004); doi:10.1038/ni1140
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review article
Mechanisms and functional significance of tumour-induced dendritic-cell defects
Dmitry Gabrilovich
Nature Reviews Immunology 4, 941–952
(December 2004); doi:10.1038/nri1498
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review article
The immunogenetics of asthma and eczema: a new focus on the epithelium
William Cookson
Nature Reviews Immunology 4, 978–988
(December 2004); doi:10.1038/nri1500
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research article
Lack of interferon response in animals to naked siRNAs
Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche and Mark E Davis
Nature Biotechnology 22, 1579–1582
(December 2004); doi:10.1038/nbt1038
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research article
Antisense and siRNA as agonists of Toll-like receptors
Sudhir Agrawal and Ekambar R Kandimalla
Nature Biotechnology 22, 1533–1537
(December 2004); doi:10.1038/nbt1042
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November
letters to nature
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
Marcus Maurer , Jochen Wedemeyer , Martin Metz , Adrian M. Piliponsky, Karsten Weller, Devavani Chatterjea, David E. Clouthier, Masashi M. Yanagisawa , Mindy Tsai and Stephen J. Galli
Nature 432, 512–516
(25 November 2004); doi:10.1038/nature03085
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article
Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors
Ioannis Tassiulas, Xiaoyu Hu, Hao Ho, Yogita Kashyap, Paul Paik, Yongmei Hu, Clifford A Lowell and Lionel B Ivashkiv
Nature Immunology 5, 1181–1189
(November 2004); doi:10.1038/ni1126
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news and views
Are dendritic cells end cells?
Ken Shortman and Li Wu
Nature Immunology 5, 1105–1106
(November 2004); doi:10.1038/ni1104-1105
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review article
Intrinsic immunity: a front-line defense against viral attack
Paul D Bieniasz
Nature Immunology 5, 1109–1115
(November 2004); doi:10.1038/ni1125
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review article
Forkhead-box transcription factors and their role in the immune system
Paul J. Coffer and Boudewijn M. T. Burgering
Nature Reviews Immunology 4, 889–899
(November 2004); doi:10.1038/nri1488
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news and views
From plankton to pathogen recognition
Robert L Modlin and Genhong Cheng
Nature Medicine 10, 1173–1174
(November 2004); doi:10.1038/nm1104-1173
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letter
Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity
Ramu A Subbramanian, Chikaya Moriya, Kristi L Martin, Fred W Peyerl, Atsuhiko Hasegawa, Akira Naoi, Heng Chhay, Patrick Autissier, Darci A Gorgone, Michelle A Lifton, Kristine Kuus-Reichel, Jörn E Schmitz, Norman L Letvin and Marcelo J Kuroda
Nature Biotechnology 22, 1429–1434
(December 2004); doi:10.1038/nbt1024
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article
Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells
Minghui Zhang, Hua Tang, Zhenhong Guo, Huazhang An, Xuejun Zhu, Wengang Song, Jun Guo, Xin Huang, Taoyong Chen, Jianli Wang and Xuetao Cao
Nature Immunology 5, 1124–1133
(November 2004); doi:10.1038/ni1130
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review article
Retroviral restriction by APOBEC proteins
Reuben S. Harris and Mark T. Liddament
Nature Reviews Immunology 4, 868–877
(November 2004); doi:10.1038/nri1489
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review article
Clinical strategies for expansion of haematopoietic stem cells
Brian P. Sorrentino
Nature Reviews Immunology 4, 878–888
(November 2004); doi:10.1038/nri1487
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letter
TCR affinity and negative regulation limit autoimmunity
Matthew A Gronski, Jonathan M Boulter, Demetrius Moskophidis, Linh T Nguyen, Kaisa Holmberg, Alisha R Elford, Elissa K Deenick, Hee O Kim, Josef M Penninger, Bernhard Odermatt, Awen Gallimore, Nicholas R J Gascoigne and Pamela S Ohashi
Nature Medicine 10, 1234–1239
(November 2004); doi:10.1038/nm1114
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news and views
Stem cells bank on ATM machine
Anthony D Whetton
Nature Medicine 10, 1166–1168
(November 2004); doi:10.1038/nm1104-1166
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article
Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
Philippe Stock, Omid Akbari, Gerald Berry, Gordon J Freeman, Rosemarie H DeKruyff and Dale T Umetsu
Nature Immunology 5, 1149–1156
(November 2004); doi:10.1038/ni1122
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article
Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses
Jinfang Zhu, Booki Min, Jane Hu-Li, Cynthia J Watson, Alex Grinberg, Qi Wang, Nigel Killeen, Joseph F Urban, Jr Liying Guo and William E Paul
Nature Immunology 5, 1157–1165
(November 2004); doi:10.1038/ni1128
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review article
Regulatory T cells: friend or foe in immunity to infection?
Kingston H. G. Mills
Nature Reviews Immunology 4, 841–855
(November 2004); doi:10.1038/nri1485
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article
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Hong Wang, Hong Liao, Mahendar Ochani, Marilou Justiniani, Xinchun Lin, Lihong Yang, Yousef Al-Abed, Haichao Wang, Christine Metz, Edmund J Miller, Kevin J Tracey and Luis Ulloa
Nature Medicine 10, 1216–1221
(November 2004); doi:10.1038/nm1124
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article
CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
Ciriana Orabona, Ursula Grohmann, Maria Laura Belladonna, Francesca Fallarino, Carmine Vacca, Roberta Bianchi, Silvia Bozza, Claudia Volpi, Benoît L Salomon, Maria Cristina Fioretti, Luigina Romani and Paolo Puccetti
Nature Immunology 5, 1134–1142
(November 2004); doi:10.1038/ni1124
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news and views
CD28-B7 bidirectional signaling: a two-way street to activation
Eric C Logue and William C Sha
Nature Immunology 5, 1103–1105
(November 2004); doi:10.1038/ni1104-1103
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review article
Recent developments in the transcriptional regulation of cytolytic effector cells
Laurie H. Glimcher, Michael J. Townsend, Brandon M. Sullivan and Graham M. Lord
Nature Reviews Immunology 4, 900–911
(November 2004); doi:10.1038/nri1490
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review article
Strategies to enhance T-cell reconstitution in immunocompromised patients
Marcel R. M. van den Brink, Önder Alpdogan and Richard L. Boyd
Nature Reviews Immunology 4, 856–867
(November 2004); doi:10.1038/nri1484
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October
article
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
Elmar Jaeckel, Myra A Lipes and Harald von Boehmer
Nature Immunology 5, 1028–1035
(October 2004); doi:10.1038/ni1120
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review article
Toll-like receptor control of the adaptive immune responses
Akiko Iwasaki and Ruslan Medzhitov
Nature Immunology 5, 987–995
(October 2004); doi:10.1038/ni1112
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review article
Gene therapy for autoimmune diseases: quo vadis?
Yuti Chernajovsky, David J. Gould and Osvaldo L. Podhajcer
Nature Reviews Immunology 4, 800–811
(October 2004); doi:10.1038/nri1459
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review article
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Ferric C. Fang
Nature Reviews Microbiology 2, 820–832
(October 2004); doi:10.1038/nrmicro1004
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letters to nature
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan and Bart Vanhaesebroeck
Nature 431, 1007–1011
(21 October 2004); doi:10.1038/nature02991
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news and views
Cancer: Negative feedback for B cells
Louis M. Staudt
The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated.
Nature 431, 919–920
(21 October 2004); doi:10.1038/431919a
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article
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
Charalampos G Spilianakis and Richard A Flavell
Nature Immunology 5, 1017–1027
(October 2004); doi:10.1038/ni1115
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article
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira
Nature Immunology 5, 1061–1068
(October 2004); doi:10.1038/ni1118
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news and views
A polarizing situation
Tasha N Sims and Michael L Dustin
Nature Immunology 5, 1012–1013
(October 2004); doi:10.1038/ni1004-1012
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review article
Interplay of natural killer cells and their receptors with the adaptive immune response
David H Raulet
Nature Immunology 5, 996–1002
(October 2004); doi:10.1038/ni1114
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review article
The multifaceted roles of TRAFs in the regulation of B-cell function
Gail A. Bishop
Nature Reviews Immunology 4, 775–786
(October 2004); doi:10.1038/nri1462
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review article
Immune responses to Listeria monocytogenes
Eric G. Pamer
Nature Reviews Immunology 4, 812–823
(October 2004); doi:10.1038/nri1461
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article
4-1BB-mediated immunotherapy of rheumatoid arthritis
Su K Seo, Jae H Choi, Young H Kim, Woo J Kang, Hye Y Park, Jae H Suh, Beom K Choi, Dass S Vinay and Byoung S Kwon
Nature Medicine 10, 1088–1094
(October 2004); doi:10.1038/nm1107
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news and views
Suppressing the self in rheumatoid arthritis
Robert S Mittler
Nature Medicine 10, 1047–1049
(October 2004); doi:10.1038/nm1004-1047
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article
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Leonardo H Travassos, Stephen E Girardin, Dana J Philpott, Didier Blanot, Marie-Anne Nahori, Catherine Werts and Ivo G Boneca
EMBO Reports 5, 1000–1006
(October 2004); doi:10.1038/sj.embor.7400248
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article
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
Jonathan C Poe, Yoko Fujimoto, Minoru Hasegawa, Karen M Haas, Ann S Miller, Isaac G Sanford, Cheryl B Bock, Manabu Fujimoto and Thomas F Tedder
Nature Immunology 5, 1078–1087
(October 2004); doi:10.1038/ni1121
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news and views
Unmasking connections in transmembrane immune signaling
Jamey D Marth
Nature Immunology 5, 1008–1010
(October 2004); doi:10.1038/ni1004-1008
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review article
The complement system in regulation of adaptive immunity
Michael C Carroll
Nature Immunology 5, 981–986
(October 2004); doi:10.1038/ni1113
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review article
Mast-cell responses to pathogens
Jean S. Marshall
Nature Reviews Immunology 4, 787–799
(October 2004); doi:10.1038/nri1460
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article
GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
Hai-Hui Xue, Julie Bollenbacher, Valentina Rovella, Radhika Tripuraneni, Yu-Bin Du, Cheng-Yu Liu, Ann Williams, J Philip McCoy and Warren J Leonard
Nature Immunology 5, 1036–1044
(October 2004); doi:10.1038/ni1117
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article
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
David L Boone, Emre E Turer, Eric G Lee, Regina-Celeste Ahmad, Matthew T Wheeler, Colleen Tsui, Paula Hurley, Marcia Chien, Sophia Chai, Osamu Hitotsumatsu, Elizabeth McNally, Cecile Pickart and Averil Ma
Nature Immunology 5, 1052–1060
(October 2004); doi:10.1038/ni1110
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news and views
DUBbing down innate immunity
Neal Silverman and Katherine Fitzgerald
Nature Immunology 5, 1010–1012
(October 2004); doi:10.1038/ni1004-1010
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review article
A stepwise epigenetic process controls immunoglobulin allelic exclusion
Yehudit Bergman and Howard Cedar
Nature Reviews Immunology 4, 753–761
(October 2004); doi:10.1038/nri1458
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article
A role for the immunological synapse in lineage commitment of CD4 lymphocytes
Roberto A. Maldonado, Darrell J. Irvine, Robert Schreiber and Laurie H. Glimcher
Nature 431, 527–532
(30 September 2004); doi:10.1038/nature02916
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article
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
Koko Katagiri, Noriko Ohnishi, Kenji Kabashima, Tomonori Iyoda, Naoki Takeda, Yoichi Shinkai, Kayo Inaba and Tatsuo Kinashi
Nature Immunology 5, 1045–1051
(October 2004); doi:10.1038/ni1111
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news and views
RAPL: taking the Rap in immunity
Leo S Price and Johannes L Bos
Nature Immunology 5, 1007–1008
(October 2004); doi:10.1038/ni1004-1007
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review article
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Andrew L. Mellor and David H. Munn
Nature Reviews Immunology 4, 762–774
(October 2004); doi:10.1038/nri1457
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article
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
Chun Geun Lee, Holger Link, Peter Baluk, Robert J Homer, Svetlana Chapoval, Vineet Bhandari, Min Jong Kang, Lauren Cohn, Yoon Keun Kim, Donald M McDonald and Jack A Elias
Nature Medicine 10, 1095–1103
(October 2004); doi:10.1038/nm1105
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news and views
VEGF obstructs the lungs
Marc E Rothenberg
Nature Medicine 10, 1041–1042
(October 2004); doi:10.1038/nm1004-1041
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review article
New drugs for asthma
Peter J. Barnes
Nature Reviews Drug Discovery 3, 831–844
(October 2004); doi:10.1038/nrd1524
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September
letters to nature
Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling
Ingrid Mecklenbräuker, Susan L. Kalled, Michael Leitges, Fabienne Mackay and Alexander Tarakhovsky
Nature 431, 456–461
(23 September 2004); doi:10.1038/nature02955
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letters to nature
NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky, Rinnat M. Porat, Ilan Stein , Rinat Abramovitch, Sharon Amit, Shafika Kasem, Elena Gutkovich-Pyest, Simcha Urieli-Shoval, Eithan Galun and Yinon Ben-Neriah
Nature 431, 461–466
(23 September 2004); doi:10.1038/nature02924
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: An inflammatory link
Fran Balkwill and Lisa M. Coussens
Nature 431, 405–406
(23 September 2004); doi:10.1038/431405a
| Full Text (HTML / PDF) |
article
RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes
Lisa K Cherry, Xiaoyu Li, Pascale Schwab, Bing Lim and Lloyd B Klickstein
Nature Immunology 5, 961–967
(September 2004); doi:10.1038/ni1103
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review article
T-cell trafficking in asthma: lipid mediators grease the way
Andrew D. Luster and Andrew M. Tager
Nature Reviews Immunology 4, 711–724
(September 2004); doi:10.1038/nri1438
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article
Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
Juan E Moyron-Quiroz, Javier Rangel-Moreno, Kim Kusser, Louise Hartson, Frank Sprague, Stephen Goodrich, David L Woodland, Frances E Lund and Troy D Randall
Nature Medicine 10, 927–934
(September 2004); doi:10.1038/nm1091
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news and views
Lung immunity: necessity is the mother of induction
Max Corbett and Jean-Pierre Kraehenbuhl
Nature Medicine 10, 904–905
(September 2004); doi:10.1038/nm0904-904
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article
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Tyler J Curiel, George Coukos, Linhua Zou, Xavier Alvarez, Pui Cheng, Peter Mottram, Melina Evdemon-Hogan, Jose R Conejo-Garcia, Lin Zhang, Matthew Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, Ben Daniel, Alan Gordon, Leann Myers, Andrew Lackner, Mary L Disis, Keith L Knutson, Lieping Chen and Weiping Zou
Nature Medicine 10, 942–949
(September 2004); doi:10.1038/nm1093
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news and views
Fatal attraction: tumors beckon regulatory T cells
Ethan M Shevach
Nature Medicine 10, 900–901
(September 2004); doi:10.1038/nm0904-900
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news and views
Epithelial cells pay a Toll for protection
Warren Strober
Nature Medicine 10, 898–900
(September 2004); doi:10.1038/nm0904-898
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article
MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells
Salomé LeibundGut-Landmann, Jean-Marc Waldburger, Caetano Reis e Sousa, Hans Acha-Orbea and Walter Reith
Nature Immunology 5, 899–908
(September 2004); doi:10.1038/ni1109
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article
Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization
Till A Röhn, Marianne Boes, Dirk Wolters, Sebastian Spindeldreher, Bernd Müller, Hanno Langen, Hidde Ploegh, Anne B Vogt and Harald Kropshofer
Nature Immunology 5, 909–918
(September 2004); doi:10.1038/ni1108
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review article
E3 ubiquitin ligases as T cell anergy factors
Daniel L Mueller
Nature Immunology 5, 883–890
(September 2004); doi:10.1038/ni1106
| Abstract | Full Text (HTML/PDF) |
review article
TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response
Michal Baniyash
Nature Reviews Immunology 4, 675–687
(September 2004); doi:10.1038/nri1434
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article
Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice
Sonia Quaratino, Ester Badami, Yun Yun Pang, Istvan Bartok, Julian Dyson, Dimitris Kioussis, Marco Londei and Luigi Maiuri
Nature Medicine 10, 920–926
(September 2004); doi:10.1038/nm1092
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news and views
Autoimmune hypothyroidism: T cells caught in the act
Sandra M McLachlan and Basil Rapoport
Nature Medicine 10, 895–896
(September 2004); doi:10.1038/nm0904-895
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article
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
Bin Liu, Sheldon Mink, Kelly A Wong, Natalie Stein, Crescent Getman, Paul W Dempsey, Hong Wu and Ke Shuai
Nature Immunology 5, 891–898
(September 2004); doi:10.1038/ni1104
| Abstract | Full Text (HTML/PDF) |
news and views
A peek at PIAS
John J O'Shea and Wendy Watford
Nature Immunology 5, 875–876
(September 2004); doi:10.1038/ni0904-875
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review article
Nalt- versus peyer's-patch-mediated mucosal immunity
Hiroshi Kiyono and Satoshi Fukuyama
Nature Reviews Immunology 4, 699–710
(September 2004); doi:10.1038/nri1439
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research article
A simple method to cure established tumors by inflammatory killing of normal cells
Gregory A Daniels, Luis Sanchez-Perez, Rosa Maria Diaz, Timothy Kottke, Jill Thompson, Maoyi Lai, Michael Gough, Mahzuz Karim, Andrew Bushell, Heung Chong, Alan Melcher, Kevin Harrington and Richard G Vile
Nature Biotechnology 22, 1125–1132
(September 2004); doi:10.1038/nbt1007
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news and views
Immunotherapy dispenses with tumor antigens
Soldano Ferrone
Nature Biotechnology 22, 1096–1098
(September 2004); doi:10.1038/nbt0904-1096
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letters to nature
A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
Michael B. Reed, Pilar Domenech, Claudia Manca, Hua Su, Amy K. Barczak, Barry N. Kreiswirth, Gilla Kaplan and Clifton E. Barry III
Nature 431, 84–87
(02 September 2004); doi:10.1038/nature02837
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article
Serine protease inhibitor 2A is a protective factor for memory T cell development
Ni Liu, Tiphanie Phillips, Manling Zhang, Yue Wang, Joseph T Opferman, Ramila Shah and Philip G Ashton–Rickardt
Nature Immunology 5, 919–926
(September 2004); doi:10.1038/ni1107
| Abstract | Full Text (HTML/PDF) |
article
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
Christopher D C Allen, K Mark Ansel, Caroline Low, Robin Lesley, Hirokazu Tamamura, Nobutaka Fujii and Jason G Cyster
Nature Immunology 5, 943–952
(September 2004); doi:10.1038/ni1100
| Abstract | Full Text (HTML/PDF) |
review article
Tolerance, not immunity, crucially depends on IL–2
Thomas R. Malek and Allison L. Bayer
Nature Reviews Immunology 4, 665–674
(September 2004); doi:10.1038/nri1435
| Summary | Full Text (HTML / PDF) |
August
letter
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor
Marcel Vergés, Frédéric Luton, Carmen Gruber, Frank Tiemann, Lorri G. Reinders, Lan Huang, Alma L. Burlingame, Carol R. Haft and Keith E. Mostov
Nature Cell Biology 6, 763–769
(August 2004); doi:10.1038/ncb1153
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article
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
Sharon H Jackson, Satish Devadas, Jaeyul Kwon, Ligia A Pinto and Mark S Williams
Nature Immunology 5, 818–827
(August 2004); doi:10.1038/ni1096
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article
B cell-specific loss of histone 3 lysine 9 methylation in the VH locus depends on Pax5
Kristen Johnson, David L Pflugh, Duonan Yu, David G T Hesslein, Kuo-I Lin, Alfred L M Bothwell, Andrei Thomas-Tikhonenko, David G Schatz and Kathryn Calame
Nature Immunology 5, 853–861
(August 2004); doi:10.1038/ni1099
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review article
Protein kinase C and beyond
Martin Spitaler and Doreen A Cantrell
Nature Immunology 5, 785–790
(August 2004); doi:10.1038/ni1097
| Abstract | Full Text (HTML/PDF) |
review article
Transmembrane adaptor proteins: organizers of immunoreceptor signalling
Václav Horejší, Weiguo Zhang and Burkhart Schraven
Nature Reviews Immunology 4, 603–616
(August 2004); doi:10.1038/nri1414
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perspectives
Innovation: Seventeen-colour flow cytometry: unravelling the immune system
Stephen P. Perfetto, Pratip K. Chattopadhyay and Mario Roederer
Nature Reviews Immunology 4, 648–655
(August 2004); doi:10.1038/nri1416
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article
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
Tomohiro Watanabe, Atsushi Kitani, Peter J Murray and Warren Strober
Nature Immunology 5, 800–808
(August 2004); doi:10.1038/ni1092
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news and views
How NOD-ing off leads to Crohn disease
Luke A J O'Neill
Nature Immunology 5, 776–778
(August 2004); doi:10.1038/ni0804-776
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review article
Fibrotic disease and the TH1/TH2 paradigm
Thomas A. Wynn
Nature Reviews Immunology 4, 583–594
(August 2004); doi:10.1038/nri1412
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letters to nature
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
Yongliang Zhang, Joseph N. Blattman, Norman J. Kennedy, Julie Duong, Thang Nguyen, Ying Wang, Roger J. Davis, Philip D. Greenberg, Richard A. Flavell and Chen Dong
Nature 430, 793–797
(12 August 2004); doi:10.1038/nature02764
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article
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
Qi-Jing Li, Aaron R Dinner, Shuyan Qi, Darrell J Irvine, Johannes B Huppa, Mark M Davis and Arup K Chakraborty
Nature Immunology 5, 791–799
(August 2004); doi:10.1038/ni1095
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news and views
Self help for T cells
Eric Hailman and Paul M Allen
Nature Immunology 5, 780–781
(August 2004); doi:10.1038/ni0804-780
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perspectives
Opinion: Inflammation and necrosis promote tumour growth
Jukka Vakkila and Michael T. Lotze
Nature Reviews Immunology 4, 641–648
(August 2004); doi:10.1038/nri1415
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news and views
Type 1 diabetes: focus on prevention
Harald von Boehmer
Nature Medicine 10, 783–784
(August 2004); doi:10.1038/nm0804-783
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research article
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
Sunil Shaunak, Sharyn Thomas, Elisabetta Gianasi, Antony Godwin, Emma Jones, Ian Teo, Kamiar Mireskandari, Philip Luthert, Ruth Duncan, Steve Patterson, Peng Khaw and Steve Brocchini
Nature Biotechnology 22, 977–984
(August 2004); doi:10.1038/nbt995
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article
CD8+ T cell contraction is controlled by early inflammation
Vladimir P Badovinac, Brandon B Porter and John T Harty
Nature Immunology 5, 809–817
(August 2004); doi:10.1038/ni1098
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article
RabGEF1 is a negative regulator of mast cell activation and skin inflammation
See-Ying Tam, Mindy Tsai, John N Snouwaert, Janet Kalesnikoff, Didier Scherrer, Susumu Nakae, Devavani Chatterjea, Donna M Bouley and Stephen J Galli
Nature Immunology 5, 844–852
(August 2004); doi:10.1038/ni1093
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review article
Matrix metalloproteinases as modulators of inflammation and innate immunity
William C. Parks , Carole L. Wilson and Yolanda S. López-Boado
Nature Reviews Immunology 4, 617–629
(August 2004); doi:10.1038/nri1418
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article
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Marisa I Gómez, Aram Lee, Bharat Reddy, Amanda Muir, Grace Soong, Allyson Pitt, Ambrose Cheung and Alice Prince
Nature Medicine 10, 842–848
(August 2004); doi:10.1038/nm1079
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news and views
Staphylococcal protein A inflames the lungs
Birgitta Henriques Normark, Staffan Normark and Anna Norrby-Teglund
Nature Medicine 10, 780–781
(August 2004); doi:10.1038/nm0804-780
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brief communication
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
Lu Chen, Pedram Hamrah, Claus Cursiefen, Qiang Zhang, Bronislaw Pytowski, J Wayne Streilein and M Reza Dana
Nature Medicine 10, 813–815
(August 2004); doi:10.1038/nm1078
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July
article
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
Kristin J Hope, Liqing Jin and John E Dick
Nature Immunology 5, 738–743
(July 2004); doi:10.1038/ni1080
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news and views
Cancer stem cells refined
David T Scadden
Nature Immunology 5, 701–703
(July 2004); doi:10.1038/ni0704-701
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review article
Post-proteasomal antigen processing for major histocompatibility complex class I presentation
Kenneth L Rock, Ian A York and Alfred L Goldberg
Nature Immunology 5, 670–677
(July 2004); doi:10.1038/ni1089
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review article
Neonatal adaptive immunity comes of age
Becky Adkins, Claude Leclerc and Stuart Marshall-Clarke
Nature Reviews Immunology 4, 553–564
(July 2004); doi:10.1038/nri1394
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review article
A new modality for immunosuppression: targeting the JAK/STAT pathway
John J. O'Shea, Marko Pesu, Dominic C. Borie and Paul S. Changelian
Nature Reviews Drug Discovery 3, 555–564
(July 2004); doi:10.1038/nrd1441
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brief communication
Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection
Stephen J. Elvin, E. Diane Williamson, Joanne C. Scott, Jeremy N. Smith, Guillermo Pérez de Lema, Silvia Chilla, Paul Clapham, Klaus Pfeffer, Detlef Schlöndorff and Bruno Luckow
Nature 430, 606–31
(22 July 2004); doi:10.1038/nature02822
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article
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
Marie-Dominique Filippi, Chad E Harris, Jarek Meller, Yi Gu, Yi Zheng and David A Williams
Nature Immunology 5, 744–751
(July 2004); doi:10.1038/ni1081
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article
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Stacey R Dillon, Cindy Sprecher, Angela Hammond, Janine Bilsborough, Maryland Rosenfeld-Franklin, Scott R Presnell, Harald S Haugen, Mark Maurer, Brandon Harder, Janet Johnston, Susan Bort, Sherri Mudri, Joseph L Kuijper, Tom Bukowski, Pamela Shea, Dennis L Dong, Maria Dasovich, Francis J Grant, Luann Lockwood, Steven D Levin, Cosette LeCiel, Kim Waggie, Heather Day, Stavros Topouzis, Janet Kramer, Rolf Kuestner, Zhi Chen, Don Foster, Julia Parrish-Novak and Jane A Gross
Nature Immunology 5, 752–760
(July 2004); doi:10.1038/ni1084
| Abstract | Full Text (HTML/PDF) |
review article
Cellular mechanisms governing cross-presentation of exogenous antigens
Anne L Ackerman and Peter Cresswell
Nature Immunology 5, 678–684
(July 2004); doi:10.1038/ni1082
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review article
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules
Colin Watts
Nature Immunology 5, 685–692
(July 2004); doi:10.1038/ni1088
| Abstract | Full Text (HTML/PDF) |
perspectives
Landmark: The road to Toll
Bruno Lemaitre
Nature Reviews Immunology 4, 521–527
(July 2004); doi:10.1038/nri1390
| Abstract | Full Text (HTML / PDF) |
article
Critical functions for c-Myb at three checkpoints during thymocyte development
Timothy P Bender, Christopher S Kremer, Manfred Kraus, Thorsten Buch and Klaus Rajewsky
Nature Immunology 5, 721–729
(July 2004); doi:10.1038/ni1085
| Abstract | Full Text (HTML/PDF) |
review article
Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII
Peter M Kloetzel
Nature Immunology 5, 661–669
(July 2004); doi:10.1038/ni1090
| Abstract | Full Text (HTML/PDF) |
review article
Toll-like receptor signalling
Shizuo Akira and Kiyoshi Takeda
Nature Reviews Immunology 4, 499–511
(July 2004); doi:10.1038/nri1391
| Abstract | Full Text (HTML / PDF) |
news and views
APCs size up antigens
Keith S Bahjat and Stephen P Schoenberger
Nature Medicine 10, 679–681
(July 2004); doi:10.1038/nm0704-679
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article
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
Zeev Pancer, Chris T. Amemiya, Götz R. A. Ehrhardt, Jill Ceitlin, G. Larry Gartland and Max D. Cooper
Nature 430, 174–180
(08 July 2004); doi:10.1038/nature02740
| Abstract | Full Text (HTML / PDF) |
news and views
Immunology: Another manifestation of GOD
Martin F. Flajnik
Nature 430, 157–158
(08 July 2004); doi:10.1038/430157a
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letters to nature
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Sanjeev Mariathasan, Kim Newton, Denise M. Monack, Domagoj Vucic, Dorothy M. French, Wyne P. Lee, Meron Roose-Girma, Sharon Erickson and Vishva M. Dixit
Nature 430, 213–218
(08 July 2004); doi:10.1038/nature02664
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letters to nature
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkBζ
Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda and Shizuo Akira
Nature 430, 218–222
(08 July 2004); doi:10.1038/nature02738
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news and views
Immunology: Polarizing a T-cell response
Sophie M. Lehar and Michael J. Bevan
Nature 430, 150–151
(08 July 2004); doi:10.1038/430150a
| Full Text (HTML / PDF) |
review
Frontal and stealth attack strategies in microbial pathogenesis
D. Scott Merrell and Stanley Falkow
Nature 430, 250–256
(08 July 2004); doi:10.1038/nature02760
| Abstract | Full Text (HTML / PDF) |
review
Inferences, questions and possibilities in Toll-like receptor signalling
Bruce Beutler
Nature 430, 257–263
(08 July 2004); doi:10.1038/nature02761
| Abstract | Full Text (HTML / PDF) |
review
Translating cell biology in vitro to immunity in vivo
Marianne Boes and Hidde L. Ploegh
Nature 430, 264–271
(08 July 2004); doi:10.1038/nature02762
| Abstract | Full Text (HTML / PDF) |
article
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa, Noriaki Shinobu, Tadaatsu Imaizumi, Makoto Miyagishi, Kazunari Taira, Shizuo Akira and Takashi Fujita
Nature Immunology 5, 730–737
(July 2004); doi:10.1038/ni1087
| Abstract | Full Text (HTML/PDF) |
news and views
RIGging an antiviral defense—it's in the CARDs
David E Levy and Isabelle J Marié
Nature Immunology 5, 699–701
(July 2004); doi:10.1038/ni0704-699
| Full Text (HTML/PDF) |
review article
Therapeutics targeting the innate immune system
Richard J. Ulevitch
Nature Reviews Immunology 4, 512–520
(July 2004); doi:10.1038/nri1396
| Abstract | Full Text (HTML / PDF) |
article
The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination
Tara Karnezis, Wim Mandemakers, Jonathan L McQualter, Binhai Zheng, Peggy P Ho, Kelly A Jordan, Belinda M Murray, Ben Barres, Marc Tessier-Lavigne and Claude C A Bernard
Nature Neuroscience 7, 736–744
(July 2004); doi:10.1038/nn1261
| Abstract | Full Text (HTML/PDF) |
article
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
Guy Cinamon, Mehrdad Matloubian, Matthew J Lesneski, Ying Xu, Caroline Low, Theresa Lu, Richard L Proia and Jason G Cyster
Nature Immunology 5, 713–720
(July 2004); doi:10.1038/ni1083
| Abstract | Full Text (HTML/PDF) |
news and views
Should we B-leavin' now?
Michael D Gunn and Garnett Kelsoe
Nature Immunology 5, 703–704
(July 2004); doi:10.1038/ni0704-703
| Full Text (HTML/PDF) |
review article
CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals
Rémy Bosselut
Nature Reviews Immunology 4, 529–540
(July 2004); doi:10.1038/nri1392
| Abstract | Full Text (HTML / PDF) |
review article
Cancer and the chemokine network
Fran Balkwill
Nature Reviews Cancer 4, 540–550
(July 2004); doi:10.1038/nrc1388
| Abstract | Full Text (HTML / PDF) |
review article
Immune signalling in neural development, synaptic plasticity and disease
Lisa M. Boulanger and Carla J. Shatz
Nature Reviews Neuroscience 5, 521–531
(July 2004); doi:10.1038/nrn1428
| Abstract | Full Text (HTML / PDF) |
June
article
A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells
Wu-Shiun Hou and Luk Van Parijs
Nature Immunology 5, 583–589
(June 2004); doi:10.1038/ni1071
| Abstract | Full Text (HTML/PDF) |
news and views
Balancing life and death
Muriel Moser
Nature Immunology 5, 559–560
(June 2004); doi:10.1038/ni0604-559
| Full Text (HTML/PDF) |
article
Exacerbated graft-versus-host disease in Pirb−/− mice
Akira Nakamura, Eiji Kobayashi and Toshiyuki Takai
Nature Immunology 5, 623–629
(June 2004); doi:10.1038/ni1074
| Abstract | Full Text (HTML/PDF) |
review article
Elaborate interactions between the immune and nervous systems
Lawrence Steinman
Nature Immunology 5, 575–581
(June 2004); doi:10.1038/ni1078
| Abstract | Full Text (HTML/PDF) |
review article
Therapeutic potential of oral tolerance
Lloyd Mayer and Ling Shao
Nature Reviews Immunology 4, 407–419
(June 2004); doi:10.1038/nri1370
| Abstract | Full Text (HTML / PDF) |
news and views
Tolerance tag team
Matthias von Herrath and Dirk Homann
Nature Medicine 10, 585–587
(June 2004); doi:10.1038/nm0604-585
| Full Text (HTML/PDF) |
article
Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors
Yoshihiro Hayakawa, Stuart P Berzins, Nadine Y Crowe, Dale I Godfrey and Mark J Smyth
Nature Immunology 5, 590–596
(June 2004); doi:10.1038/ni1069
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article
CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
Antoine Perchellet, Ingunn Stromnes, Jennifer M Pang and Joan Goverman
Nature Immunology 5, 606–614
(June 2004); doi:10.1038/ni1073
| Abstract | Full Text (HTML/PDF) |
article
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
Katsuto Hozumi, Naoko Negishi, Daisuke Suzuki, Natsumi Abe, Yusuke Sotomaru, Norikazu Tamaoki, Carolina Mailhos, David Ish-Horowicz, Sonoko Habu and Michael J Owen
Nature Immunology 5, 638–644
(June 2004); doi:10.1038/ni1075
| Abstract | Full Text (HTML/PDF) |
review article
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
Kazuo Sugamura, Naoto Ishii and Andrew D. Weinberg
Nature Reviews Immunology 4, 420–431
(June 2004); doi:10.1038/nri1371
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
Seung-Yong Seong and Polly Matzinger
Nature Reviews Immunology 4, 469–478
(June 2004); doi:10.1038/nri1372
| Abstract | Full Text (HTML / PDF) |
article
Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells
Tetsuya Yamagata, Diane Mathis and Christophe Benoist
Nature Immunology 5, 597–605
(June 2004); doi:10.1038/ni1070
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news and views
Nondeletional pathways for the development of autoreactive thymocytes
Albert Bendelac
Nature Immunology 5, 557–558
(June 2004); doi:10.1038/ni0604-557
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article
CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity
Jie Chen, Paul A McLean, Benjamin G Neel, Gbolahan Okunade, Gary E Shull and Henry H Wortis
Nature Immunology 5, 651–657
(June 2004); doi:10.1038/ni1072
| Abstract | Full Text (HTML/PDF) |
review article
Adhesion mechanisms regulating the migration of monocytes
Beat A. Imhof and Michel Aurrand-Lions
Nature Reviews Immunology 4, 432–444
(June 2004); doi:10.1038/nri1375
| Abstract | Full Text (HTML / PDF) |
news and views
A mightier mouse with human adaptive immunity
Marie H Kosco-Vilbois
Nature Biotechnology 22, 684–685
(June 2004); doi:10.1038/nbt0604-684
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letters to nature
The transcriptional programme of antibody class switching involves the repressor Bach2
Akihiko Muto, Satoshi Tashiro, Osamu Nakajima, Hideto Hoshino, Satoru Takahashi, Eiichirou Eakoda, Dai Ikebe, Masayuki Yamamoto & Kazuhiko Igarashi
Nature 429, 566–571
(03 June 2004); doi:10.1038/nature02596
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article
'Educated' dendritic cells act as messengers from memory to naive T helper cells
Oral Alpan, Eric Bachelder, Eda Isil, Heinz Arnheiter and Polly Matzinger
Nature Immunology 5, 615–622
(June 2004); doi:10.1038/ni1077
| Abstract | Full Text (HTML/PDF) |
news and views
Cutting into innate immunity
Astar Winoto
Nature Immunology 5, 563–564
(June 2004); doi:10.1038/ni0604-563
| Full Text (HTML/PDF) |
review article
Mathematical and computational models of immune-receptor signalling
Byron Goldstein, James R. Faeder and William S. Hlavacek
Nature Reviews Immunology 4, 445–456
(June 2004); doi:10.1038/nri1374
| Abstract | Full Text (HTML / PDF) |
May
article
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
John P Manis, Julio C Morales, Zhenfang Xia, Jeffery L Kutok, Frederick W Alt and Phillip B Carpenter
Nature Immunology 5, 481–487
(May 2004); doi:10.1038/ni1067
| Abstract | Full Text (HTML/PDF) |
news and views
Paradigm switching in the germinal center
Jennifer E Posey, Vicky L Brandt and David B Roth
Nature Immunology 5, 476–477
(May 2004); doi:10.1038/ni0504-476
| Full Text (HTML/PDF) |
article
Analysis of regulatory CD8 T cells in Qa-1-deficient mice
Dan Hu, Koichi Ikizawa, Linrong Lu, Marie E Sanchirico, Mari L Shinohara and Harvey Cantor
Nature Immunology 5, 516–523
(May 2004); doi:10.1038/ni1063
| Abstract | Full Text (HTML/PDF) |
news and views
Resurrecting CD8+ suppressor T cells
Leonard Chess and Hong Jiang
Nature Immunology 5, 469–471
(May 2004); doi:10.1038/ni0504-469
| Full Text (HTML/PDF) |
article
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
Heather J Hinton, Dario R Alessi and Doreen A Cantrell
Nature Immunology 5, 539–545
(May 2004); doi:10.1038/ni1062
| Abstract | Full Text (HTML/PDF) |
review article
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
Margot Thome
Nature Reviews Immunology 4, 348–359
(May 2004); doi:10.1038/nri1352
| Abstract | Full Text (HTML / PDF) |
review article
Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
Masayuki Miyasaka and Toshiyuki Tanaka
Nature Reviews Immunology 4, 360–370
(May 2004); doi:10.1038/nri1354
| Abstract | Full Text (HTML / PDF) |
article
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
Etienne Meylan, Kim Burns, Kay Hofmann, Vincent Blancheteau, Fabio Martinon, Michelle Kelliher and Jürg Tschopp
Nature Immunology 5, 503–507
(May 2004); doi:10.1038/ni1061
| Abstract | Full Text (HTML/PDF) |
news and views
Toll signaling: RIPping off the TNF pathway
Gregory M Barton and Ruslan Medzhitov
Nature Immunology 5, 472–474
(May 2004); doi:10.1038/ni0504-472
| Full Text (HTML/PDF) |
article
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
Yiping Yang, Ching-Tai Huang, Xiaopei Huang and Drew M Pardoll
Nature Immunology 5, 508–515
(May 2004); doi:10.1038/ni1059
| Abstract | Full Text (HTML/PDF) |
article
T cell killing does not require the formation of a stable mature immunological synapse
Marco A Purbhoo, Darrell J Irvine, Johannes B Huppa and Mark M Davis
Nature Immunology 5, 524–530
(May 2004); doi:10.1038/ni1058
| Abstract | Full Text (HTML/PDF) |
article
A single class II myosin modulates T cell motility and stopping, but not synapse formation
Jordan Jacobelli, Stephen A Chmura, Denis B Buxton, Mark M Davis and Matthew F Krummel
Nature Immunology 5, 531–538
(May 2004); doi:10.1038/ni1065
| Abstract | Full Text (HTML/PDF) |
review article
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
Lieping Chen
Nature Reviews Immunology 4, 336–347
(May 2004); doi:10.1038/nri1349
| Abstract | Full Text (HTML / PDF) |
article
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
Miriam Merad, Petra Hoffmann, Erik Ranheim, Sarah Slaymaker, Markus G Manz, Sergio A Lira, Israel Charo, Donald N Cook, Irving L Weissman, Samuel Strober and Edgar G Engleman
Nature Medicine 10, 510–517
(May 2004); doi:10.1038/nm1038
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news and views
Tanning before transplant: lancing the Langerhans cell
Stephen G Emerson
Nature Medicine 10, 451–452
(May 2004); doi:10.1038/nm0504-451
| Full Text (HTML/PDF) |
letter
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
Ram Kumar Mathur, Amit Awasthi, Pallavi Wadhone, B Ramanamurthy and Bhaskar Saha
Nature Medicine 10, 540–544
(May 2004); doi:10.1038/nm1045
| First Paragraph | Full Text (HTML/PDF) |
letter
SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2
Hong Zhang, Gromoslaw A Smolen, Rachel Palmer, Andrea Christoforou, Sander van den Heuvel and Daniel A Haber
Nature Genetics 36, 507–511
(May 2004); doi:10.1038/ng1336
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article
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
Carole Couillault, Nathalie Pujol, Jérôme Reboul, Laurence Sabatier, Jean-François Guichou, Yuji Kohara and Jonathan J Ewbank
Nature Immunology 5, 488–494
(May 2004); doi:10.1038/ni1060
| Abstract | Full Text (HTML/PDF) |
news and views
Dissecting worm immunity
Jonathan Hodgkin
Nature Immunology 5, 471–472
(May 2004); doi:10.1038/ni0504-471
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review article
Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation
Klaus Ley and Geoffrey S. Kansas
Nature Reviews Immunology 4, 325–336
(May 2004); doi:10.1038/nri1351
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news and views
Arming the osteoclast
Roland Baron
Nature Medicine 10, 458–460
(May 2004); doi:10.1038/nm0504-458
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review article
Time to draw breath: asthma-susceptibility genes are identified
Marsha Wills-Karp and Susan L. Ewart
Nature Reviews Genetics 5, 376–387
(May 2004); doi:10.1038/nrg1326
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letters to nature
Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro
Kouichi Ozaki, Katsumi Inoue, Hiroshi Sato, Aritoshi Iida, Yozo Ohnishi, Akihiro Sekine, Hideyuki Sato, Keita Odashiro, Masakiyo Nobuyoshi, Masatsugu Hori, Yusuke Nakamura and Toshihiro Tanaka
Nature 429, 72–75
(06 May 2004); doi:10.1038/nature02502
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letters to nature
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
Maya Saleh, John P. Vaillancourt, Rona K. Graham, Matthew Huyck, Srinivasa M. Srinivasula, Emad S. Alnemri, Martin H. Steinberg, Vikki Nolan, Clinton T. Baldwin, Richard S. Hotchkiss, Timothy G. Buchman, Barbara A. Zehnbauer, Michael R. Hayden, Lindsay A. Farrer, Sophie Roy and Donald W. Nicholson
Nature 429, 75–79
(06 May 2004); doi:10.1038/nature02451
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news and views
Human genetics: An inflammatory issue
Kevin J. Tracey and H. Shaw Warren
Nature 429, 35–37
(06 May 2004); doi:10.1038/429035a
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article
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Tsung-Hsien Chuang and Richard J Ulevitch
Nature Immunology 5, 495–502
(May 2004); doi:10.1038/ni1066
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news and views
Nature's fortress against infection
Steven A Wasserman
Nature Immunology 5, 474–475
(May 2004); doi:10.1038/ni0504-474
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review article
The weight of leptin in immunity
Antonio La Cava and Giuseppe Matarese
Nature Reviews Immunology 4, 371–379
(May 2004); doi:10.1038/nri1350
| Abstract | Full Text (HTML / PDF) |
perspectives
Innovation: Novel ChIP-based strategies to uncover transcription factor target genes in the immune system
Amy S. Weinmann
Nature Reviews Immunology 4, 381–386
(May 2004); doi:10.1038/nri1353
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April
article
Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation
Yingyu Ma, Hongtao Liu, Hoang Tu-Rapp, Hans-Juergen Thiesen, Saleh M Ibrahim, Shawn M Cole and Richard M Pope
Nature Immunology 5, 380–387
(April 2004); doi:10.1038/ni1054
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article
Continued maturation of thymic emigrants in the periphery
Tamar E Boursalian, Jonathan Golob, David M Soper, Cristine J Cooper and Pamela J Fink
Nature Immunology 5, 418–425
(April 2004); doi:10.1038/ni1049
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review article
Membranes as messengers in T cell adhesion signaling
Michael L Dustin, Trever G Bivona and Mark R Philips
Nature Immunology 5, 363–372
(April 2004); doi:10.1038/ni1057
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review article
Feedback regulation of lymphocyte signalling
Michael Reth and Tilman Brummer
Nature Reviews Immunology 4, 269–278
(April 2004); doi:10.1038/nri1335
| Abstract | Full Text (HTML / PDF) |
letter
Human lupus T cells resist inactivation and escape death by upregulating COX-2
Luting Xu, Li Zhang, Yajun Yi, Hee-Kap Kang and Syamal K Datta
Nature Medicine 10, 411–415
(April 2004); doi:10.1038/nm1005
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article
GADD45β/GADD45γ and MEKK 4 comprise a genetic pathway mediating STAT4-independent IFN-γ production in T cells
Hongbo Chi, Binfeng Lu, Mutsuhiro Takekawa, Roger J Davis and Richard A Flavell
EMBO journal 23, 1576–1586
(April 2004); doi: 10.1038/sj.emboj.7600173
| Abstract | Full Text (HTML/PDF) |
article
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
Elizabeth K Brint, Damo Xu, Haiying Liu, Aisling Dunne, Andrew N J McKenzie, Luke A J O'Neill and Foo Y Liew
Nature Immunology 5, 373–379
(April 2004); doi:10.1038/ni1050
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article
Locomotion of monocytes on endothelium is a critical step during extravasation
Alan R Schenkel, Zahra Mamdouh and William A Muller
Nature Immunology 5, 393–400
(April 2004); doi:10.1038/ni1051
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news and views
Crawling and INTEGRating apical cues
Ronen Alon and Francis W Luscinskas
Nature Immunology 5, 351–353
(April 2004); doi:10.1038/ni0404-351
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review article
Developing a new paradigm for thymus organogenesis
C. Clare Blackburn and Nancy R. Manley
Nature Reviews Immunology 4, 278–289
(April 2004); doi:10.1038/nri1331
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review article
Immunotherapeutic uses of CpG oligodeoxynucleotides
Dennis M. Klinman
Nature Reviews Immunology 4, 249–259
(April 2004); doi:10.1038/nri1329
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brief communication
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Vicente E Torres, Xiaofang Wang, Qi Qian, Stefan Somlo, Peter C Harris, Vincent H Gattone and II
Nature Medicine 10, 363–364
(April 2004); doi:10.1038/nm1004
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letter
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
Harry Björkbacka, Vidya V Kunjathoor, Kathryn J Moore, Stephanie Koehn, Christine M Ordija, Melinda A Lee, Terry Means, Kristen Halmen, Andrew D Luster, Douglas T Golenbock and Mason W Freeman
Nature Medicine 10, 416–421
(April 2004); doi:10.1038/nm1008
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research article
Differential quantitative analysis of MHC ligands by mass spectrometry using stable isotope labeling
Claudia Lemmel, Steffen Weik, Ute Eberle, Jörn Dengjel, Thomas Kratt, Horst-Dieter Becker, Hans-Georg Rammensee and Stefan Stevanovic;
Nature Biotechnology 22, 450–454
(April 2004); doi:10.1038/nbt947
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letters to nature
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Takako Koga , Masanori Inui, Kazuya Inoue, Sunhwa Kim, Ayako Suematsu, Eiji Kobayashi, Toshio Iwata, Hiroshi Ohnishi, Takashi Matozaki, Tatsuhiko Kodama, Tadatsugu Taniguchi, Hiroshi Takayanagi and Toshiyuki Takai
Nature 428, 758–763
(15 April 2004); doi:10.1038/nature02444
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article
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Christopher L Karp, Leah M Flick, Kiwon W Park, Samir Softic, Todd M Greer, Raquel Keledjian, Rong Yang, Jasim Uddin, William B Guggino, Sowsan F Atabani, Yasmine Belkaid, Yan Xu, Jeffrey A Whitsett, Frank J Accurso, Marsha Wills-Karp and Nicos A Petasis
Nature Immunology 5, 388–392
(April 2004); doi:10.1038/ni1056
| Abstract | Full Text (HTML/PDF) |
news and views
New therapeutic key for cystic fibrosis: a role for lipoxins
Daiya Takai, Takahide Nagase and Takao Shimizu
Nature Immunology 5, 357–358
(April 2004); doi:10.1038/ni0404-357
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review article
Acquired and natural memory T cells join forces at the mucosal front line
Hilde Cheroutre and Loui Madakamutil
Nature Reviews Immunology 4, 290–300
(April 2004); doi:10.1038/nri1333
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article
Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
Pietro G Andres, Kimberly C Howland, Ajay Nirula, Lawrence P Kane, Luke Barron, Douglas Dresnek, Ali Sadra, John Imboden, Arthur Weiss and Abul K Abbas
Nature Immunology 5, 435–442
(April 2004); doi:10.1038/ni1044
| Abstract | Full Text (HTML/PDF) |
article
Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
Norihiko Watanabe, Shino Hanabuchi, Vassili Soumelis, Wei Yuan, Stephen Ho, Rene de Waal Malefyt and Yong-Jun Liu
Nature Immunology 5, 426–434
(April 2004); doi:10.1038/ni1048
| Abstract | Full Text (HTML/PDF) |
review article
Clinical islet transplantation: advances and immunological challenges
Camillo Ricordi and Terry B. Strom
Nature Reviews Immunology 4, 259–268
(April 2004); doi:10.1038/nri1332
| Abstract | Full Text (HTML / PDF) |
news and views
Embedding T cells in the matrix
Liisa K Selin and Markus Cornberg
Nature Medicine 10, 343–345
(April 2004); doi:10.1038/nm0404-343
| Full Text (HTML/PDF) |
review article
Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention
Martin Braddock and Anthony Quinn
Nature Reviews Drug Discovery 3, 330–340
(April 2004); doi:10.1038/nrd1342
| Abstract | Full Text (HTML / PDF) |
article
Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro
Thomas M Schmitt, Renée F de Pooter, Matthew A Gronski, Sarah K Cho, Pamela S Ohashi and Juan Carlos Zúñga-Pflücker
Nature Immunology 5, 410–417
(April 2004); doi:10.1038/ni1055
| Abstract | Full Text (HTML/PDF) |
news and views
From totipotency to T in a dish
Ellen V Rothenberg
Nature Immunology 5, 359–360
(April 2004); doi:10.1038/ni0404-359
| Full Text (HTML/PDF) |
article
The STAT3 isoforms α and β have unique and specific functions
Diego Maritano, Michelle L Sugrue, Silvia Tininini, Sarah Dewilde, Birgit Strobl, XinPing Fu, Victoria Murray-Tait, Roberto Chiarle and Valeria Poli
Nature Immunology 5, 401–409
(April 2004); doi:10.1038/ni1052
| Abstract | Full Text (HTML/PDF) |
perspectives
Timeline: Jurkat T cells and development of the T-cell receptor signalling paradigm
Robert T. Abraham and Arthur Weiss
Nature Reviews Immunology 4, 301–308
(April 2004); doi:10.1038/nri1330
| Abstract | Full Text (HTML / PDF) |
March
article
Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
Patrick S Costello, Robert H Nicolas, Yasuyuki Watanabe, Ian Rosewell and Richard Treisman
Nature Immunology 5, 289–298
(March 2004); doi:10.1038/ni1038
| Abstract | Full Text (HTML/PDF) |
article
PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing
Ildikó Gyõry, Jian Wu, György Fejér, Edward Seto and Kenneth L Wright
Nature Immunology 5, 299–308
(March 2004); doi:10.1038/ni1046
| Abstract | Full Text (HTML/PDF) |
news and views
Sounds of a silent Blimp-1
Karen W Makar and Christopher B Wilson
Nature Immunology 5, 241–242
(March 2004); doi:10.1038/ni0304-241
| Full Text (HTML/PDF) |
article
B cell receptor signal strength determines B cell fate
Stefano Casola, Kevin L Otipoby, Marat Alimzhanov, Sibille Humme, Nathalie Uyttersprot, Jeffery L Kutok, Michael C Carroll and Klaus Rajewsky
Nature Immunology 5, 317–327
(March 2004); doi:10.1038/ni1036
| Abstract | Full Text (HTML/PDF) |
review article
Notch regulation of lymphocyte development and function
Freddy Radtke, Anne Wilson, Stephane J C Mancini and H Robson MacDonald
Nature Immunology 5, 247–253
(March 2004); doi:10.1038/ni1045
| Abstract | Full Text (HTML/PDF) |
review article
NOX enzymes and the biology of reactive oxygen
J. David Lambeth
Nature Reviews Immunology 4, 181–189
(March 2004); doi:10.1038/nri1312
| Abstract | Full Text (HTML / PDF) |
letter
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
Motoshi Ichikawa, Takashi Asai, Toshiki Saito, Go Yamamoto, Sachiko Seo, Ieharu Yamazaki, Tetsuya Yamagata, Kinuko Mitani, Shigeru Chiba, Hisamaru Hirai, Seishi Ogawa and Mineo Kurokawa
Nature Medicine 10, 299–304
(March 2004); doi:10.1038/nm997
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news and views
AML-1 steps up to the platelets
Brenda J Irvin and Scott W Hiebert
Nature Medicine 10, 238–239
(March 2004); doi:10.1038/nm0304-238
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letters to nature
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J. Kaufman, Lars Eckmann, Donald G. Guiney and Michael Karin
Nature 428, 341–345
(18 March 2004); doi:10.1038/nature02405
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letter
Lipid raft proteins have a random distribution during localized activation of the T-cell receptor
Oleg O. Glebov and Benjamin J. Nichols
Nature Cell Biology 6, 238–243
(March 2004); doi:10.1038/ncb1103
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news and views
To cluster or not to cluster: FRETting over rafts
Susan K. Pierce
Nature Cell Biology 6, 180–181
(March 2004); doi:10.1038/ncb0304-180
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article
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Vigo Heissmeyer, Fernando Macián, Sin-Hyeog Im, Rajat Varma, Stefan Feske, K Venuprasad, Hua Gu, Yun-Cai Liu, Michael L Dustin and Anjana Rao
Nature Immunology 5, 255–265
(March 2004); doi:10.1038/ni1047
| Abstract | Full Text (HTML/PDF) |
news and views
Behind the scenes of anergy: a tale of three E3s
Matti Davis and Yinon Ben-Neriah
Nature Immunology 5, 238–240
(March 2004); doi:10.1038/ni0304-238
| Full Text (HTML/PDF) |
review article
Immune surveillance in the skin: mechanisms and clinical consequences
Thomas S. Kupper and Robert C. Fuhlbrigge
Nature Reviews Immunology 4, 211–222
(March 2004); doi:10.1038/nri1310
| Abstract | Full Text (HTML / PDF) |
research article
Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
Dong-Ho Kim, Michael Longo, Young Han, Patric Lundberg, Edouard Cantin and John J Rossi
Nature Biotechnology 22, 321–325
(March 2004); doi:10.1038/nbt940
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news and views
Knockdown by RNAi—proceed with caution
Charles E Samuel
Nature Biotechnology 22, 280–282
(March 2004); doi:10.1038/nbt0304-280
| Full Text (HTML/PDF) |
article
Cis association of Ly49A with MHC class I restricts natural killer cell inhibition
Marie-Agnés Doucey, Léonardo Scarpellino, Jacques Zimmer, Philippe Guillaume, Immanuel F Luescher, Claude Bron and Werner Held
Nature Immunology 5, 328–336
(March 2004); doi:10.1038/ni1043
| Abstract | Full Text (HTML/PDF) |
news and views
Having it both ways: MHC recognition in cis and trans
Paul J Leibson and Larry R Pease
Nature Immunology 5, 237–238
(March 2004); doi:10.1038/ni0304-237
| Full Text (HTML/PDF) |
perspectives
Opinion: Death-defying immunity: do apoptotic cells influence antigen processing and presentation?
Matthew L. Albert
Nature Reviews Immunology 4, 223–231
(March 2004); doi:10.1038/nri1308
| Abstract | Full Text (HTML / PDF) |
article
ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation
Sophie Faure, Laura Inés Salazar-Fontana, Monique Semichon, Victor L J Tybulewicz, Georges Bismuth, Alain Trautmann, Ronald N Germain and Jérôme Delon
Nature Immunology 5, 272–279
(March 2004); doi:10.1038/ni1039
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article
Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
Xiaolong Liu and Rémy Bosselut
Nature Immunology 5, 280–288
(March 2004); doi:10.1038/ni1040
| Abstract | Full Text (HTML/PDF) |
review article
Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
Eric Vivier and Nicolas Anfossi
Nature Reviews Immunology 4, 190–198
(March 2004); doi:10.1038/nri1306
| Abstract | Full Text (HTML / PDF) |
February
letters to nature
The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Jatinder Ahluwalia, Andrew Tinker, Lucie H. Clapp, Michael R. Duchen, Andrey Y. Abramov, Simon Pope, Muriel Nobles and Anthony W. Segal
Nature 427, 853–858
(26 February 2004); doi:10.1038/nature02356
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article
Saposin C is required for lipid presentation by human CD1b
Florian Winau, Vera Schwierzeck, Robert Hurwitz, Natascha Remmel, Peter A Sieling, Robert L Modlin, Steven A Porcelli, Volker Brinkmann, Masahiko Sugita, Konrad Sandhoff, Stefan H E Kaufmann and Ulrich E Schaible
Nature Immunology 5, 169–174
(February 2004); doi:10.1038/ni1035
| Abstract | Full Text (HTML/PDF) |
article
Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells
Suk-Jo Kang and Peter Cresswell
Nature Immunology 5, 175–181
(February 2004); doi:10.1038/ni1034
| Abstract | Full Text (HTM | 
