letter Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Miguel A. Sanjuan et al. Nature450, 1253–1257
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article CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
Pushpa Pandiyan, Lixin Zheng, Satoru Ishihara, Jennifer Reed & Michael J Lenardo Nature Immunology8, 1353–1362
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news and views Competition for cytokines: Treg cells take all
Alexander Scheffold, Kenneth M Murphy & Thomas Höfer Nature Immunology8, 1285–1287
(December 2007); doi:10.1038/ni1207-1285
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article T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
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news and views Building the bionic T cell
Drew M Pardoll Nature Medicine13, 1411–1413
(December 2007); doi:10.1038/nm1207-1411
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letter Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
Manuel A Friese et al. Nature Medicine13, 1483–1489
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letter A viral microRNA functions as an orthologue of cellular miR-155
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article NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
Tiffany Horng, Jelena S Bezbradica & Ruslan Medzhitov Nature Immunology8, 1345–1352
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news and views Unexpected partnership between IL-15 and DAP10
Francesco Colucci Nature Immunology8, 1289–1291
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review Engulfment of apoptotic cells: signals for a good meal
Kodi S. Ravichandran & Ulrike Lorenz Nature Reviews Immunology7, 964–974
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article Bv8 regulates myeloid-cell-dependent tumour angiogenesis
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letter Adaptive immunity maintains occult cancer in an equilibrium state
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news and views Cancer: Immune pact with the enemy
Cornelis J. M. Melief Nature450, 803–804
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article Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
Jason S Stumhofer et al. Nature Immunology8, 1363–1371
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article Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
Denise C Fitzgerald et al. Nature Immunology8, 1372–1379
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article A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
Amit Awasthi et al. Nature Immunology8, 1380–1389
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article TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology
Mandy J McGeachy, Kristian S Bak-Jensen, Yi Chen, Cristina M Tato, Wendy Blumenschein, Terrill McClanahan & Daniel J Cua Nature Immunology8, 1390–1397
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news and views IL-10 or not IL-10: that is the question
Dragana Jankovic & Giorgio Trinchieri Nature Immunology8, 1281–1283
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review Interferons at age 50: past, current and future impact on biomedicine
Ernest C. Borden et al. Nature Reviews Drug Discovery6, 975–990
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November
letter Calcineurin sets the bandwidth for discrimination of signals during thymocyte development
Elena M. Gallo et al. Nature450, 731–735
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review Immunological and genetic bases of new primary immunodeficiencies
László Maródi & Luigi D. Notarangelo Nature Reviews Immunology7, 851–861
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article TLR4 enhances TGF-β signaling and hepatic fibrosis
Ekihiro Seki et al. Nature Medicine13, 1324–1332
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news and views A deer in the headlights: BAMBI meets liver fibrosis
Scott L Friedman Nature Medicine13, 1281–1282
(November 2007); doi:10.1038/nm1107-1281
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review Complement-targeted therapeutics
Daniel Ricklin & John D Lambris Nature Biotechnology25, 1265–1275
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perspective Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
Russell P Rother, Scott A Rollins, Christopher F Mojcik, Robert A Brodsky & Leonard Bell Nature Biotechnology25, 1256–1264
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letter The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Lauren W. Collison et al. Nature450, 566–569
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article COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence
Suchithra Menon, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard A Flavell & Ning Wei Nature Immunology8, 1236–1245
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review The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
Dominique Ferrandon, Jean-Luc Imler, Charles Hetru & Jules A. Hoffmann Nature Reviews Immunology7, 862–874
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article Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease
Markus Weckmann et al. Nature Medicine13, 1308–1315
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perspective Chemokines: a new class of neuromodulator?
William Rostène, Patrick Kitabgi & Stéphane Mélik Parsadaniantz Nature Reviews Neuroscience8, 895–903
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article Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
Chengbin Wu et al. Nature Biotechnology25, 1290–1297
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news and views Two heads are better than one
Sherie L Morrison Nature Biotechnology25, 1233–1234
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letter CD16 promotes Escherichia coli sepsis through an FcRbold gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation
Fabiano Pinheiro da Silva et al. Nature Medicine13, 1368–1374
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letter Inhibition of FcεRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes
Alirio J Melendez et al. Nature Medicine13, 1375–1381
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news and views Worms tame mast cells
Edward J Pearce Nature Medicine13, 1288–1289
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letter Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
Di Yu et al. Nature450, 299–303
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article The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
Rossana Zaru, Natalia Ronkina, Matthias Gaestel, J Simon C Arthur & Colin Watts Nature Immunology8, 1227–1235
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review Common themes in the assembly and architecture of activating immune receptors
Matthew E. Call & Kai W. Wucherpfennig Nature Reviews Immunology7, 841–850
(November 2007); doi:10.1038/nri2186
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review Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance
Anita Q. Gomes, Daniel V. Correia & Bruno Silva-Santos EMBO Reports8, 1024–1030
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letter A translocation signal for delivery of oomycete effector proteins into host plant cells
Stephen C. Whisson et al. Nature450, 115–118
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letter Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Tobias Junt et al. Nature450, 110–114
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article Identification of clonogenic common Flt3+M–CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay & Markus G Manz Nature Immunology8, 1207–1216
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article Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
Shalin H Naik et al. Nature Immunology8, 1217–1226
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news and views Dendritic cell genealogy: a new stem or just another branch?
Miriam Merad & Florent Ginhoux Nature Immunology8, 1199–1201
(November 2007); doi:10.1038/ni1107-1199
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October
article Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling
Asaf Spiegel, Shoham Shivtiel, Alexander Kalinkovich, Aya Ludin, Neta Netzer, Polina Goichberg, Yaara Azaria, Igor Resnick, Izhar Hardan, Herzel Ben-Hur, Arnon Nagler, Menachem Rubinstein & Tsvee Lapidot Nature Immunology8, 1123–1131
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review Recent advances in antigen processing and presentation
Peter E Jensen Nature Immunology8, 1041–1048
(October 2007); doi:10.1038/ni1516
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review IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation
Paolo Puccetti & Ursula Grohmann Nature Reviews Immunology7, 817–823
(October 2007); doi:10.1038/nri2163
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article Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Laura Soucek, Elizabeth R Lawlor, Darya Soto, Ksenya Shchors, Lamorna Brown Swigart & Gerard I Evan Nature Medicine13, 1211–1218
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article T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2
Yoshihiko Tanaka et al. Nature Immunology8, 1067–1075
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review Genetic analysis of resistance to viral infection
Bruce Beutler et al. Nature Reviews Immunology7, 753–766
(October 2007); doi:10.1038/nri2174
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letter Adaptive immune cells temper initial innate responses
Kwang Dong Kim et al. Nature Medicine13, 1248–1252
(October 2007); doi:10.1038/nm1633
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news and views Not so fast: adaptive suppression of innate immunity
Noah W Palm & Ruslan Medzhitov Nature Medicine13, 1142–1144
(October 2007); doi:10.1038/nm1007-1142b
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review Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer
David R. Clemmons Nature Reviews Drug Discovery6, 821–833
(October 2007); doi:10.1038/nrd2359
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letter Phagocyte-derived catecholamines enhance acute inflammatory injury
Michael A. Flierl, Daniel Rittirsch, Brian A. Nadeau, Anthony J. Chen, J. Vidya Sarma, Firas S. Zetoune, Stephanie R. McGuire, Rachel P. List, Danielle E. Day, L. Marco Hoesel, Hongwei Gao, Nico Van Rooijen, Markus S. Huber-Lang, Richard R. Neubig & Peter A. Ward Nature449, 721–725
(11 October 2007); doi:10.1038/nature06185
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article 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
Jung-Hyun Park, Stanley Adoro, Philip J Lucas, Sophia D Sarafova, Amala S Alag, Loretta L Doan, Batu Erman, Xiaolong Liu, Wilfried Ellmeier, Remy Bosselut, Lionel Feigenbaum & Alfred Singer Nature Immunology8, 1049–1059
(October 2007); doi:10.1038/ni1512
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news and views CD8+ T cells are kept in tune by modulating IL-7 responsiveness
Juan Carlos Zúñiga-Pflücker Nature Immunology8, 1027–1028
(October 2007); doi:10.1038/ni1007-1027
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review Calcium signalling and cell-fate choice in B cells
Andrew M. Scharenberg, Lisa A. Humphries & David J. Rawlings Nature Reviews Immunology7, 778–789
(October 2007); doi:10.1038/nri2172
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article Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells
Ryan T Phan, Masumichi Saito, Yukiko Kitagawa, Anthony R Means & Riccardo Dalla-Favera Nature Immunology8, 1132–1139
(October 2007); doi:10.1038/ni1508
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news and views Two in one: dual function of an invertebrate antigen receptor
Thomas Boehm Nature Immunology8, 1031–1033
(October 2007); doi:10.1038/ni1007-1031
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review Evolving functions of endothelial cells in inflammation
Jordan S. Pober & William C. Sessa Nature Reviews Immunology7, 803–815
(October 2007); doi:10.1038/nri2171
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September
letter Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
César Cobaleda, Wolfram Jochum & Meinrad Busslinger Nature449, 473–477
(27 September 2007); doi:10.1038/nature06159
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news and views Immunology: Changed destiny
Huafeng Xie & Stuart H. Orkin Nature449, 410–411
(27 September 2007); doi:10.1038/449410a
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letter Rag mutations reveal robust alternative end joining
Barbara Corneo, Rebecca L. Wendland, Ludovic Deriano, Xiaoping Cui, Isaac A. Klein, Serre-Yu Wong, Suzzette Arnal, Abigail J. Holub, Geoffrey R. Weller, Bette A. Pancake, Sundeep Shah, Vicky L. Brandt, Katheryn Meek & David B. Roth Nature449, 483–486
(27 September 2007); doi:10.1038/nature06168
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letter IgH class switching and translocations use a robust non-classical end-joining pathway
Catherine T. Yan, Cristian Boboila, Ellen Kris Souza, Sonia Franco, Thomas R. Hickernell, Michael Murphy, Sunil Gumaste, Mark Geyer, Ali A. Zarrin, John P. Manis, Klaus Rajewsky & Frederick W. Alt Nature449, 478–482
(27 September 2007); doi:10.1038/nature06020
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article IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
Liang Zhou, Ivaylo I Ivanov, Rosanne Spolski, Roy Min, Kevin Shenderov, Takeshi Egawa, David E Levy, Warren J Leonard & Dan R Littman Nature Immunology8, 967–974
(September 2007); doi:10.1038/ni1488
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review Multiple sclerosis: a complicated picture of autoimmunity
Henry F McFarland & Roland Martin Nature Immunology8, 913–919
(September 2007); doi:10.1038/ni1507
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review Developmental pathways that generate natural-killer-cell diversity in mice and humans
Nicholas D. Huntington, Christian A. J. Vosshenrich & James P. Di Santo Nature Reviews Immunology7, 703–714
(September 2007); doi:10.1038/nri2154
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review Sonic hedgehog signalling in T-cell development and activation
Tessa Crompton, Susan V. Outram & Ariadne L. Hager-Theodorides Nature Reviews Immunology7, 726–735
(September 2007); doi:10.1038/nri2151
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perspective Promiscuity and the single receptor: NKG2D
Robert A. Eagle & John Trowsdale Nature Reviews Immunology7, 737–744
(September 2007); doi:10.1038/nri2144
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review Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
Stephen D. Miller, Danielle M. Turley & Joseph R. Podojil Nature Reviews Immunology7, 665–677
(September 2007); doi:10.1038/nri2153
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article Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
Paul J Norman, Laurent Abi-Rached, Ketevan Gendzekhadze, Daniel Korbel, Michael Gleimer, Don Rowley, Dan Bruno, Christine V F Carrington, Dasdayanee Chandanayingyong, Yih-Hsin Chang, Catalina Crespí, Güher Saruhan-Direskeneli, Patricia A Fraser, Kamran Hameed, Giorgi Kamkamidze, Kwadwo A Koram, Zulay Layrisse, Nuria Matamoros, Joan Milà, Myoung Hee Park, Ramasamy M Pitchappan, D Dan Ramdath, Ming-Yuh Shiau, Henry A F Stephens, Siske Struik, David H Verity, Robert W Vaughan, Dolly Tyan, Ronald W Davis, Eleanor M Riley, Mostafa Ronaghi & Peter Parham Nature Genetics39, 1092–1099
(September 2007); doi:10.1038/ng2111
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brief communication EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
Michael Lazarus, Kyoko Yoshida, Roberto Coppari, Caroline E Bass, Takatoshi Mochizuki, Bradford B Lowell & Clifford B Saper Nature Neuroscience10, 1131–1133
(September 2007); doi:10.1038/nn1949
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letter Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
Mark A. Travis, Boris Reizis, Andrew C. Melton, Emma Masteller, Qizhi Tang, John M. Proctor, Yanli Wang, Xin Bernstein, Xiaozhu Huang, Louis F. Reichardt, Jeffrey A. Bluestone & Dean Sheppard Nature449, 361–365
(20 September 2007); doi:10.1038/nature06110
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article Development, cytokine profile and function of human interleukin 17-producing helper T cells
Nicholas J Wilson, Katia Boniface, Jason R Chan, Brent S McKenzie, Wendy M Blumenschein, Jeanine D Mattson, Beth Basham, Kathleen Smith, Taiying Chen, Franck Morel, Jean-Claude Lecron, Robert A Kastelein, Daniel J Cua, Terrill K McClanahan, Edward P Bowman & Rene de Waal Malefyt Nature Immunology8, 950–957
(September 2007); doi:10.1038/ni1497
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article Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
Eva V Acosta-Rodriguez, Giorgio Napolitani, Antonio Lanzavecchia & Federica Sallusto Nature Immunology8, 942–949
(September 2007); doi:10.1038/ni1496
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article The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
Anne Brüstle, Sylvia Heink, Magdalena Huber, Christine Rosenplänter, Christine Stadelmann, Philipp Yu, Enrico Arpaia, Tak W Mak, Thomas Kamradt & Michael Lohoff Nature Immunology8, 958–966
(September 2007); doi:10.1038/ni1500
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news and views TH-17 differentiation: of mice and men
Arian Laurence & John J O'Shea Nature Immunology8, 903–905
(September 2007); doi:10.1038/ni0907-903
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article Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Dan Feng, Christopher J Bond, Lauren K Ely, Jennifer Maynard & K Christopher Garcia Nature Immunology8, 975–983
(2007); doi:10.1038/ni1502
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article MALT1 directs B cell receptor-induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit
Uta Ferch, Christian Meyer zum Büschenfelde, Andreas Gewies, Elmar Wegener, Sandra Rauser, Christian Peschel, Daniel Krappmann & Jürgen Ruland Nature Immunology8, 984–991
(2007); doi:10.1038/ni1493
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review Getting to the site of inflammation: the leukocyte adhesion cascade updated
Klaus Ley, Carlo Laudanna, Myron I. Cybulsky & Sussan Nourshargh Nature Reviews Immunology7, 678–689
(September 2007); doi:10.1038/nri2156
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article Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Lionel Apetoh, François Ghiringhelli, Antoine Tesniere, Michel Obeid, Carla Ortiz, Alfredo Criollo, Grégoire Mignot, M Chiara Maiuri, Evelyn Ullrich, Patrick Saulnier, Huan Yang, Sebastian Amigorena, Bernard Ryffel, Franck J Barrat, Paul Saftig, Francis Levi, Rosette Lidereau, Catherine Nogues, Jean-Paul Mira, Agnès Chompret, Virginie Joulin, Françoise Clavel-Chapelon, Jean Bourhis, Fabrice André, Suzette Delaloge, Thomas Tursz, Guido Kroemer & Laurence Zitvogel Nature Medicine13, 1050–1059
(2007); doi:10.1038/nm1622
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article Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
Craig L Maynard, Laurie E Harrington, Karen M Janowski, James R Oliver, Carlene L Zindl, Alexander Y Rudensky & Casey T Weaver Nature Immunology8, 931–941
(September 2007); doi:10.1038/ni1504
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news and views Regula'ten' the gut
Paulo Vieira & Anne O'Garra Nature Immunology8, 905–907
(September 2007); doi:10.1038/ni0907-905
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article Crystal structure of the IL-15–IL-15Rα complex, a cytokine-receptor unit presented in trans
Mami Chirifu, Chiharu Hayashi, Teruya Nakamura, Sachiko Toma, Tsuyoshi Shuto, Hirofumi Kai, Yuriko Yamagata, Simon J Davis & Shinji Ikemizu Nature Immunology8, 1001–1007
(September 2007); doi:10.1038/ni1492
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review Calcium signalling in lymphocyte activation and disease
Stefan Feske Nature Reviews Immunology7, 690–702
(September 2007); doi:10.1038/nri2152
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perspective Building better magic bullets — improving unconjugated monoclonal antibody therapy for cancer
Louis M. Weiner Nature Reviews Cancer7, 701–706
(September 2007); doi:10.1038/nrc2209
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letter Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids
Xiangtian Long, Shenglou Deng, Jochen Mattner, Zhuo Zang, Dapeng Zhou, Nathan McNary, Randal D Goff, Luc Teyton, Albert Bendelac & Paul B Savage Nature Chemical Biology3, 559–564
(September 2007); doi:10.1038/nchembio.2007.19
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August
article Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
Marta A Toscano, Germán A Bianco, Juan M Ilarregui, Diego O Croci, Jorge Correale, Joseph D Hernandez, Norberto W Zwirner, Francoise Poirier, Eleanor M Riley, Linda G Baum & Gabriel A Rabinovich Nature Immunology8, 825–834
(August 2007); doi:10.1038/ni1482
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review B-cell anergy: from transgenic models to naturally occurring anergic B cells?
John C. Cambier, Stephen B. Gauld, Kevin T. Merrell & Barbara J. Vilen Nature Reviews Immunology7, 633–643
(August 2007); doi:10.1038/nri2133
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article E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
Kurt Bachmaier, Sophie Toya, Xiaopei Gao, Thomas Triantafillou, Sean Garrean, Gye Young Park, Randall S Frey, Stephen Vogel, Richard Minshall, John W Christman, Chinnaswamy Tiruppathi & Asrar B Malik Nature Medicine13, 920–926
(August 2007); doi:10.1038/nm1607
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article Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
Farbod Shojaei, Xiumin Wu, Ajay K Malik, Cuiling Zhong, Megan E Baldwin, Stefanie Schanz, Germaine Fuh, Hans-Peter Gerber & Napoleone Ferrara Nature Biotechnology25, 911–920
(August 2007); doi:10.1038/nbt1323
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article Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Xiao-Qing Qiu, He Wang, Bei Cai, Lan-Lan Wang & Shi-Tao Yue Nature Biotechnology25, 921–929
(August 2007); doi:10.1038/nbt1320
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news and views Antibodies cut down to size
Robert Charles Ladner Nature Biotechnology25, 875–877
(August 2007); doi:10.1038/nbt0807-875
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letter Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira & Toshiaki Ohteki Nature448, 929–933
(23 August 2007); doi:10.1038/nature06033
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letter An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
Matthieu Giraud, Richard Taubert, Claire Vandiedonck, Xiayi Ke, Matthieu Lévi-Strauss, Franco Pagani, Francisco E. Baralle, Bruno Eymard, Christine Tranchant, Philippe Gajdos, Angela Vincent, Nick Willcox, David Beeson, Bruno Kyewski & Henri-Jean Garchon Nature448, 934–937
(23 August 2007); doi:10.1038/nature06066
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article Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1
Yufeng Shi, Yan Feng, Jiuhong Kang, Chang Liu, Zhenxin Li, Dangsheng Li, Wei Cao, Ju Qiu, Zhengliang Guo, Enguang Bi, Lei Zang, Chuanzhen Lu, Jingwu Z Zhang & Gang Pei Nature Immunology8, 817–824
(August 2007); doi:10.1038/ni1489
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news and views Arresting autoimmunity by blocking β-arrestin 1
Terra J Frederick & Stephen D Miller Nature Immunology8, 791–792
(August 2007); doi:10.1038/ni0807-791
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review Molecular mechanisms of CD4+ T-cell anergy
C. Garrison Fathman & Neil B. Lineberry Nature Reviews Immunology7, 599–609
(August 2007); doi:10.1038/nri2131
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article IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Elena Bulanova, Martin Metz, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Vadim Budagian, Julien Giron-Michel, Ernst Brandt, Ralf Paus & Silvia Bulfone-Paus Nature Medicine13, 927–934
(August 2007); doi:10.1038/nm1615
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news and views The curiosity of IL-15
Peter A Ward Nature Medicine13, 903–904
(August 2007); doi:10.1038/nm0807-903
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progress Beneficial suicide: why neutrophils die to make NETs
Volker Brinkmann & Arturo Zychlinsky Nature Reviews Microbiology5, 577–582
(August 2007); doi:10.1038/nrmicro1710
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article Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
Nicole-Claudia Meisner, Martin Hintersteiner, Kurt Mueller, Roman Bauer, Jan-Marcus Seifert, Hans-Ulrich Naegeli, Johannes Ottl, Lukas Oberer, Christian Guenat, Serge Moss, Nathalie Harrer, Maximilian Woisetschlaeger, Christof Buehler, Volker Uhl & Manfred Auer Nature Chemical Biology3, 508–515
(August 2007); doi:10.1038/nchembio.2007.14
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article P-selectin primes leukocyte integrin activation during inflammation
Hai-Bo Wang, Jin-Tao Wang, Lei Zhang, Zhen H Geng, Wei-Li Xu, Tao Xu, Yuqing Huo, Xueliang Zhu, Edward F Plow, Ming Chen & Jian-Guo Geng Nature Immunology8, 882–892
(August 2007); doi:10.1038/ni1491
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review Tolerogenic dendritic cells and the quest for transplant tolerance
Adrian E. Morelli & Angus W. Thomson Nature Reviews Immunology7, 610–621
(August 2007); doi:10.1038/nri2132
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perspective A decade of AIRE
Diane Mathis & Christophe Benoist Nature Reviews Immunology7, 645–650
(August 2007); doi:10.1038/nri2136
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letter Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Kenshi Yamasaki, Anna Di Nardo, Antonella Bardan, Masamoto Murakami, Takaaki Ohtake, Alvin Coda, Robert A Dorschner, Chrystelle Bonnart, Pascal Descargues, Alain Hovnanian, Vera B Morhenn & Richard L Gallo Nature Medicine13, 975–980
(August 2007); doi:10.1038/nm1616
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news and views Rosacea: skin innate immunity gone awry?
Charles L Bevins & Fu-Tong Liu Nature Medicine13, 904–906
(August 2007); doi:10.1038/nm0807-904
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article Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
Marco Idzko, Hamida Hammad, Menno van Nimwegen, Mirjam Kool, Monique A M Willart, Femke Muskens, Henk C Hoogsteden, Werner Luttmann, Davide Ferrari, Francesco Di Virgilio, J Christian Virchow, Jr & Bart N Lambrecht Nature Medicine13, 913–919
(August 2007); doi:10.1038/nm1617
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brief communications arising Crystallography: Crystallographic evidence for deviating C3b structure
Bert J. C. Janssen, Randy J. Read, Axel T. Brünger & Piet Gros Nature448, E1–E2
(9 August 2007); doi:10.1038/nature06102
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brief communications arising Crystallography: Crystallographic evidence for deviating C3b structure (Reply)
A. Abdul Ajees, Krishnasamy Gunasekaran, Sthanam V. L. Narayana & H. M. Krishna Murthy Nature448, E2–E3
(9 August 2007); doi:10.1038/nature06103
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article Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, Hyacinth Tabarias, Mariapia A Degli-Esposti, Grant Dewson, Simon N Willis, Noboru Motoyama, David C S Huang, Stephen L Nutt, David M Tarlinton & Andreas Strasser Nature Immunology8, 856–863
(August 2007); doi:10.1038/ni1487
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review Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
Maria-Grazia Roncarolo & Manuela Battaglia Nature Reviews Immunology7, 585–598
(August 2007); doi:10.1038/nri2138
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article Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
Tom Taghon, Mary A Yui & Ellen V Rothenberg Nature Immunology8, 845–855
(August 2007); doi:10.1038/ni1486
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news and views No DL1 Notch ligand? GATA be a mast cell
Susan Winandy & Melissa Brown Nature Immunology8, 796–797
(August 2007); doi:10.1038/ni0807-796
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review CD3-specific antibodies: a portal to the treatment of autoimmunity
Lucienne Chatenoud & Jeffrey A. Bluestone Nature Reviews Immunology7, 622–632
(August 2007); doi:10.1038/nri2134
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brief communication Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Cristina Sobacchi, Annalisa Frattini, Matteo M Guerrini, Mario Abinun, Alessandra Pangrazio, Lucia Susani, Robbert Bredius, Grazia Mancini, Andrew Cant, Nick Bishop, Peter Grabowski, Andrea Del Fattore, Chiara Messina, Gabriella Errigo, Fraser P Coxon, Debbie I Scott, Anna Teti, Michael J Rogers, Paolo Vezzoni, Anna Villa & Miep H Helfrich Nature Genetics39, 960–962
(August 2007); doi:10.1038/ng2076
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July
letter Protective and therapeutic role for αB-crystallin in autoimmune demyelination
Shalina S. Ousman, Beren H. Tomooka, Johannes M. van Noort, Eric F. Wawrousek, Kevin O'Conner, David A. Hafler, Raymond A. Sobel, William H. Robinson & Lawrence Steinman Nature448, 474–479
(26 July 2007); doi:10.1038/nature05935
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news and views Inflammatory disease: Assault on the guardian
Richard M. Ransohoff Nature448, 421–422
(26 July 2007); doi:10.1038/448421a
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letter Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Roza Nurieva, Xuexian O. Yang, Gustavo Martinez, Yongliang Zhang, Athanasia D. Panopoulos, Li Ma, Kimberly Schluns, Qiang Tian, Stephanie S. Watowich, Anton M. Jetten & Chen Dong Nature448, 480–483
(26 July 2007); doi:10.1038/nature05969
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letter IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Thomas Korn, Estelle Bettelli, Wenda Gao, Amit Awasthi, Anneli Jäger, Terry B. Strom, Mohamed Oukka & Vijay K. Kuchroo Nature448, 484–487
(26 July 2007); doi:10.1038/nature05970
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news and views Immunology: Narcissistic helpers
Matthew T. Palmer & Casey T. Weaver Nature448, 416–418
(26 July 2007); doi:10.1038/448416a
| Full Text (HTML / PDF) |
letter DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Akinori Takaoka, ZhiChao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda, Yusuke Ohba & Tadatsugu Taniguchi Nature448, 501–505
(26 July 2007); doi:10.1038/nature06013
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news and views Immunology: Sensing the enemy within
Hongbo Chi & Richard A. Flavell Nature448, 422–423
(26 July 2007); doi:10.1038/448423a
| Full Text (HTML / PDF) |
review Unravelling the pathogenesis of inflammatory bowel disease
R. J. Xavier & D. K. Podolsky Nature448, 427–434
(26 July 2007); doi:10.1038/nature06005
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article Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
Stella Maris Ranuncolo, Jose M Polo, Jamil Dierov, Michael Singer, Tracy Kuo, John Greally, Roland Green, Martin Carroll & Ari Melnick Nature Immunology8, 705–714
(July 2007); doi:10.1038/ni1478
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article α1β1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis
Curdin Conrad, Onur Boyman, Giulia Tonel, Adrian Tun-Kyi, Ute Laggner, Antonin de Fougerolles, Victor Kotelianski, Humphrey Gardner & Frank O Nestle Nature Medicine13, 836–842
(July 2007); doi:10.1038/nm1605
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news and views The problem with upward mobility
Johann E Gudjonsson & James T Elder Nature Medicine13, 786–787
(July 2007); doi:10.1038/nm0707-786
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letter Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
Chun-Jen Chen, Hajime Kono, Douglas Golenbock, George Reed, Shizuo Akira & Kenneth L Rock Nature Medicine13, 851–856
(July 2007); doi:10.1038/nm1603
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news and views IL-1α responds to necrotic cell death
Keith B Elkon Nature Medicine13, 778–780
(July 2007); doi:10.1038/nm0707-778
| Summary | Full Text (HTML / PDF) |
brief communication A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
David A van Heel, Lude Franke, Karen A Hunt, Rhian Gwilliam, Alexandra Zhernakova, Mike Inouye, Martin C Wapenaar, Martin C N M Barnardo, Graeme Bethel, Geoffrey K T Holmes, Con Feighery, Derek Jewell, Dermot Kelleher, Parveen Kumar, Simon Travis, Julian RF Walters, David S Sanders, Peter Howdle, Jill Swift, Raymond J Playford, William M McLaren, M Luisa Mearin, Chris J Mulder, Ross McManus, Ralph McGinnis, Lon R Cardon, Panos Deloukas & Cisca Wijmenga Nature Genetics39, 827–829
(July 2007); doi:10.1038/ng2058
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review The contribution of immunology to the rational design of novel antibacterial vaccines
Stefan H.E. Kaufmann Nature Reviews Microbiology5, 491–504
(July 2007); doi:10.1038/nrmicro1688
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review The perfect mix: recent progress in adjuvant research
Bruno Guy Nature Reviews Microbiology5, 505–517
(July 2007); doi:10.1038/nrmicro1681
| Summary | Full Text (HTML / PDF) |
letter A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity
Tracy R. Rosebrock, Lirong Zeng, Jennifer J. Brady, Robert B. Abramovitch, Fangming Xiao & Gregory B. Martin Nature448, 370–374
(19 July 2007); doi:10.1038/nature05966
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article IgEb immune complexes activate macrophages through FcγRIV binding
Masayuki Hirano, Randall S Davis, W David Fine, Shugo Nakamura, Kentaro Shimizu, Hirokazu Yagi, Koichi Kato, Robert P Stephan & Max D Cooper Nature Immunology8, 762–771
(July 2007); doi:10.1038/ni1477
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review T cell development: better living through chromatin
Michael S Krangel Nature Immunology8, 687–694
(July 2007); doi:10.1038/ni1484
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review How Ebola and Marburg viruses battle the immune system
Mansour Mohamadzadeh, Lieping Chen & Alan L. Schmaljohn Nature Reviews Immunology7, 556–694
(July 2007); doi:10.1038/nri2098
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article Fen1 mutations result in autoimmunity, chronic inflammation and cancers
Li Zheng, Huifang Dai, Mian Zhou, Mei Li, Purnima Singh, Junzhuan Qiu, Walter Tsark, Qin Huang, Kemp Kernstine, Xuemei Zhang, Dongxin Lin & Binghui Shen Nature Medicine13, 812–819
(July 2007); doi:10.1038/nm1599
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article Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR8
Stella Maris Ranuncolo, Jose M Polo, Jamil Dierov, Michael Singer, Tracy Kuo, John Greally, Roland Green, Martin Carroll & Ari Melnick Nature Immunology8, 705–714
(July 2007); doi:10.1038/ni1478
| Summary | Full Text (HTML / PDF) |
article L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
Greta Guarda, Miroslav Hons, Silvia F Soriano, Alex Y Huang, Rosalind Polley, Alfonso Martín-Fontecha, Jens V Stein, Ronald N Germain, Antonio Lanzavecchia & Federica Sallusto Nature Immunology8, 743–752
(July 2007); doi:10.1038/ni1469
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news and views Armed and ready: How effector T cells deploy in reactive lymph nodes to modulate immunity9
David W O'Neill & Nina Bhardwaj Nature Immunology8, 679–681
(July 2007); doi:10.1038/ni0707-679
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review Life and death in peripheral T cells
Peter H. Krammer, Rüdiger Arnold & Inna N. Lavrik Nature Reviews Immunology7, 532–542
(July 2007); doi:10.1038/nri2115
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letter CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Natalie A. Borg, Kwok S. Wun, Lars Kjer-Nielsen, Matthew C. J. Wilce, Daniel G. Pellicci, Ruide Koh, Gurdyal S. Besra, Mandvi Bharadwaj, Dale I. Godfrey, James McCluskey & Jamie Rossjohn Nature448, 44–49
(5 July 2007); doi:10.1038/nature05907
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news and views Immunology: How a T cell sees sugar
D. Branch Moody Nature448, 36–37
(5 July 2007); doi:10.1038/nature05890
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article Ligand-induced conformational changes allosterically activate Toll-like receptor 9
Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M Sirois, Dionne C G Klein, Brian G Monks, C James McKnight, Marc S Lamphier, W Paul Duprex, Terje Espevik & Douglas T Golenbock Nature Immunology8, 772–779
(July 2007); doi:10.1038/ni1479
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news and views TLRs bent into shape
You-Me Kim, Melanie M Brinkmann & Hidde L Ploegh Nature Immunology8, 675–677
(July 2007); doi:10.1038/ni0707-675
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review Control points in NKT-cell development
Dale I. Godfrey & Stuart P. Berzins Nature Reviews Immunology7, 505–518
(July 2007); doi:10.1038/nri2116
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brief communication Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Miles Parkes et al. Nature Genetics39, 830–832
(July 2007); doi:10.1038/ng2061
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June
letter Macrophage-specific PPAR γ controls alternative activation and improves insulin resistance
Justin I. Odegaard, Roberto R. Ricardo-Gonzalez, Matthew H. Goforth, Christine R. Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W. Ferrante & Ajay Chawla Nature447, 1116–1120
(28 June 2007); doi:10.1038/nature05894
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article Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
Ashleigh Hodges, Katherine Sharrocks, Mariola Edelmann, Dilair Baban, Arnaud Moris, Olivier Schwartz, Hal Drakesmith, Kay Davies, Benedikt Kessler, Andrew McMichael & Alison Simmons Nature Immunology8, 569–577
(June 2007); doi:10.1038/ni1470
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news and views DC-SIGN 'AIDS' HIV immune evasion and infection
Anthony L Cunningham, Andrew N Harman & Heather Donaghy Nature Immunology8, 556–558
(June 2007); doi:10.1038/ni0607-556
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article Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
Salomé LeibundGut-Landmann, Olaf Grosß, Matthew J Robinson, Fabiola Osorio, Emma C Slack, S Vicky Tsoni, Edina Schweighoffer, Victor Tybulewicz, Gordon D Brown, Jürgen Ruland & Caetano Reis e Sousa Nature Immunology8, 630–638
(June 2007); doi:10.1038/ni1460
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review TGFβ signalling in control of T-cell-mediated self-reactivity
Yuri P Rubtsov & Alexander Y Rudensky Nature Reviews Immunology7, 443–453
(June 2007); doi:10.1038/nri2095
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perspective Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg Nature Reviews Immunology7, 479–453
(June 2007); doi:10.1038/nri2091
| Summary | Full Text (HTML / PDF) |
article TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
Ahjoku Amadi-Obi, Cheng-Rong Yu, Xuebin Liu, Rashid M Mahdi, Grace Levy Clarke, Robert B Nussenblatt, Igal Gery, Yun Sang Lee & Charles E Egwuagu Nature Medicine13, 711–718
(June 2007); doi:10.1038/nm1585
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letter Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
Hind Medyouf, Hélène Alcalde, Caroline Berthier, Marie Claude Guillemin, Nuno R dos Santos, Anne Janin, Didier Decaudin, Hugues de Thé & Jacques Ghysdael Nature Medicine13, 736–741
(June 2007); doi:10.1038/nm1588
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news and views Linking calcineurin activity to leukemogenesis
Martin R Müller & Anjana Rao Nature Medicine13, 669–671
(June 2007); doi:10.1038/nm0607-669
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review The unique role of natural killer T cells in the response to microorganisms
Emmanuel Tupin, Yuki Kinjo & Mitchell Kronenberg Nature Reviews Microbiology5, 405–417
(June 2007); doi:10.1038/nrmicro1657
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news and views Immunology: Short-term memory
Benjamin N. Gantner & Harinder Singh Nature447, 916–917
(21 June 2007); doi:10.1038/447916a
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article Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
Young Jun Kang, Sung Ouk Kim, Shigeki Shimada, Motoyuki Otsuka, Alim Seit-Nebi, Byoung S Kwon, Tania H Watts & Jiahuai Han Nature Immunology8, 601–609
(June 2007); doi:10.1038/ni1471
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article Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
Sushil Kumar Pathak, Sanchita Basu, Kunal Kumar Basu, Anirban Banerjee, Shresh Pathak, Asima Bhattacharyya, Tsuneyasu Kaisho, Manikuntala Kundu & Joyoti Basu Nature Immunology8, 610–618
(June 2007); doi:10.1038/ni1468
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review Cytokines in the pathogenesis of rheumatoid arthritis
Iain B. McInnes & Georg Schett Nature Reviews Immunology7, 429–442
(June 2007); doi:10.1038/nri2094
| Summary | Full Text (HTML / PDF) |
letter Mast cells promote atherosclerosis by releasing proinflammatory cytokines
Jiusong Sun, Galina K Sukhova, Paul J Wolters, Min Yang, Shiro Kitamoto, Peter Libby, Lindsey A MacFarlane, Jon Mallen-St Clair & Guo-Ping Shi Nature Medicine13, 719–724
(June 2007); doi:10.1038/nm1601
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letter Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Jan M. Schwab, Nan Chiang, Makoto Arita & Charles N. Serhan Nature447, 869–874
(14 June 2007); doi:10.1038/nature05877
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article The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways
Tiejun Zhao, Long Yang, Qiang Sun, Meztli Arguello, Dean W Ballard, John Hiscott & Rongtuan Lin Nature Immunology8, 592–600
(June 2007); doi:10.1038/ni1465
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perspective Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg Nature Reviews Immunology7, 479–485
(June 2007); doi:10.1038/nri2091
| Summary | Full Text (HTML / PDF) |
progress TH1 cells control themselves by producing interleukin-10
Anne O'Garra & Paulo Vieira Nature Reviews Immunology7, 425–428
(June 2007); doi:10.1038/nri2097
| Summary | Full Text (HTML / PDF) |
letter Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists
Rebecca A Buonpane, Hywyn R O Churchill, Beenu Moza, Eric J Sundberg, Marnie L Peterson, Patrick M Schlievert & David M Kranz Nature Medicine13, 725–729
(June 2007); doi:10.1038/nm1584
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review Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
William J. Steinbach, Jennifer L. Reedy, Robert A. Cramer, Jr, John R. Perfect & Joseph Heitman Nature Reviews Microbiology5, 418–430
(June 2007); doi:10.1038/nrmicro1680
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article PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit
Takashi Tanaka, Michael J Grusby & Tsuneyasu Kaisho Nature Immunology8, 584–591
(June 2007); doi:10.1038/ni1464
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article The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Hiromitsu Hara, Chitose Ishihara, Arata Takeuchi, Takayuki Imanishi, Liquan Xue, Stephan W Morris, Masanori Inui, Toshiyuki Takai, Akira Shibuya, Shinobu Saijo, Yoichiro Iwakura, Naohito Ohno, Haruhiko Koseki, Hiroki Yoshida, Josef M Penninger & Takashi Saito Nature Immunology8, 619–629
(June 2007); doi:10.1038/ni1466
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news and views All roads lead to CARD9
Marco Colonna Nature Immunology8, 554–555
(June 2007); doi:10.1038/ni0607-554
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review The role of junctional adhesion molecules in vascular inflammation
Christian Weber, Line Fraemohs & Elisabetta Dejana Nature Reviews Immunology7, 467–477
(June 2007); doi:10.1038/nri2096
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review Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
William J. Steinbach, Jennifer L. Reedy, Robert A. Cramer, Jr, John R. Perfect & Joseph Heitman Nature Reviews Microbiology5, 418–430
(June 2007); doi:10.1038/nrmicro1680
| Summary | Full Text (HTML / PDF) |
May
letter Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands
Brett K. Kaiser, Daesong Yim, I-Ting Chow, Segundo Gonzalez, Zhenpeng Dai, Henning H. Mann, Roland K. Strong, Veronika Groh & Thomas Spies Nature447, 482–486
(24 May 2007); doi:10.1038/nature05768
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article Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
Suntaek Hong, Seunghwan Lim, Allen G Li, Chan Lee, Youn Sook Lee, Eun-Kyung Lee, Seok Hee Park, Xiao-Jing Wang & Seong-Jin Kim Nature Immunology8, 504–513
(May 2007); doi:10.1038/ni1451
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news and views Smads keep TABs on inflammation
Rashu B Seth & Zhijian J Chen Nature Immunology8, 477–478
(May 2007); doi:10.1038/ni0507-477
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article A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
Annick Mayor, Fabio Martinon, Thibaut De Smedt, Virginie Pétrilli & Jürg Tschopp Nature Immunology8, 497–503
(May 2007); doi:10.1038/ni1459
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news and views Epithelial NF-κB maintains host gut microflora homeostasis
Yinon Ben-Neriah & Marc Schmidt-Supprian Nature Immunology8, 479–481
(May 2007); doi:10.1038/ni0507-479
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article Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets
Georgina Xanthou, Themis Alissafi, Maria Semitekolou, Davina C M Simoes, Erasmia Economidou, Mina Gaga, Bart N Lambrecht, Clare M Lloyd & Vily Panoutsakopoulou Nature Medicine13, 570–578
(May 2007); doi:10.1038/nm1580
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news and views The bridge between dendritic cells and asthma
Mari L Shinohara & Harvey Cantor Nature Medicine13, 536–538
(May 2007); doi:10.1038/nm0507-536
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article Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
Ursula Grohmann, Claudia Volpi, Francesca Fallarino, Silvia Bozza, Roberta Bianchi, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Emira Ayroldi, Giuseppe Nocentini, Louis Boon, Francesco Bistoni, Maria C Fioretti, Luigina Romani, Carlo Riccardi & Paolo Puccetti Nature Medicine13, 579–586
(May 2007); doi:10.1038/nm1563
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review More than one reason to rethink the use of peptides in vaccine design
Anthony W. Purcell, James McCluskey & Jamie Rossjohn Nature Reviews Drug Discovery6, 404–414
(May 2007); doi:10.1038/nrd2224
| Summary | Full Text (HTML / PDF) |
review Foxp3 in control of the regulatory T cell lineage
Ye Zheng & Alexander Y Rudensky Nature Immunology8, 457–462
(May 2007); doi:10.1038/ni1455
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review Pax5: the guardian of B cell identity and function
César Cobaleda, Alexandra Schebesta, Alessio Delogu & Meinrad Busslinger Nature Immunology8, 463–470
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essay Trawling for treasure: tales of T-bet
Laurie H Glimcher Nature Immunology8, 448–450
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review The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Luke A. J. O'Neill & Andrew G. Bowie Nature Reviews Immunology7, 353–364
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review TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Roberto Baccala, Kasper Hoebe, Dwight H Kono, Bruce Beutler & Argyrios N Theofilopoulos Nature Methods13, 543–551
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review Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman Nature Methods13, 552–559
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article Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
Andrew T Miller, Mark Sandberg, Yina H Huang, Michael Young, Susan Sutton, Karsten Sauer & Michael P Cooke Nature Immunology8, 514–521
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review Regulation of lymphocyte development by Notch signaling
Kenji Tanigaki & Tasuku Honjo Nature Immunology8, 451–456
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essay Blimp-1 over Budapest
Mark M Davis Nature Immunology8, 445–447
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article MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen, Regina Krohn, Hongqi Lue, Julia L Gregory, Alma Zernecke, Rory R Koenen, Manfred Dewor, Ivan Georgiev, Andreas Schober, Lin Leng, Teake Kooistra, Günter Fingerle-Rowson, Pietro Ghezzi, Robert Kleemann, Shaun R McColl, Richard Bucala, Michael J Hickey & Christian Weber Nature Medicine13, 587–596
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review Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
Kate L. Jeffrey, Montserrat Camps, Christian Rommel & Charles R. Mackay Nature Reviews Drug Discovery6, 391–403
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letter Chitin induces accumulation in tissue of innate immune cells associated with allergy
Tiffany A. Reese, Hong-Erh Liang, Andrew M. Tager, Andrew D. Luster, Nico Van Rooijen, David Voehringer & Richard M. Locksley Nature447, 92–96
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article Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas Golenbock, Cherilyn Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K Crow, Katherine A Fitzgerald, Eicke Latz, Peter A Kiener & Anthony J Coyle Nature Immunology8, 487–496
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news and views TLR9 and DNA 'feel' RAGE
Arthur M Krieg Nature Immunology8, 475–477
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review New developments in FcεRI regulation, function and inhibition
Stefan Kraft & Jean-Pierre Kinet Nature Reviews Immunology7, 365–378
(May 2007); doi:10.1038/nri2072
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April
article Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
Katharina Aschenbrenner, Louise M D'Cruz, Elisabeth H Vollmann, Maria Hinterberger, Jan Emmerich, Lee Kim Swee, Antonius Rolink & Ludger Klein Nature Immunology8, 351–358
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article Regulatory T cell development in the absence of functional Foxp3
Wen Lin, Dipica Haribhai, Lance M Relland, Nga Truong, Marc R Carlson, Calvin B Williams & Talal A Chatila Nature Immunology8, 359–368
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news and views Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance
Takashi Nomura & Shimon Sakaguchi Nature Immunology8, 333–334
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perspective FOXP3 modifies the phenotypic and functional properties of regulatory T cells
Daniel J. Campbell & Steven F. Ziegler Nature Reviews Immunology7, 305–310
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review Inflammation in prostate carcinogenesis
Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe, Jianfeng Xu, Henrik Grönberg, Charles G. Drake, Yasutomo Nakai, William B. Isaacs & William G. Nelson Nature Reviews Cancer7, 256–269
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review Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Masao Matsuoka & Kuan-Teh Jeang Nature Reviews Cancer7, 270–280
(April 2007); doi:10.1038/nrc2111
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article An anti-infective peptide that selectively modulates the innate immune response
Monisha G Scott, Edie Dullaghan, Neeloffer Mookherjee, Natalie Glavas, Matthew Waldbrook, Annick Thompson, Aikun Wang, Ken Lee, Silvana Doria, Pam Hamill, Jie Jessie Yu, Yuexin Li, Oreola Donini, M Marta Guarna, B Brett Finlay, John R North & Robert E W Hancock Nature Biotechnology25, 465–472
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letter TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Michaela U. Gack, Young C. Shin, Chul-Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue & Jae U. Jung Nature446, 916–920
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review Siglecs and their roles in the immune system
Paul R. Crocker, James C. Paulson & Ajit Varki Nature Reviews Immunology7, 255–266
(April 2007); doi:10.1038/nri2056
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article Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen R Clark, Adrienne C Ma, Samantha A Tavener, Braedon McDonald, Zahra Goodarzi, Margaret M Kelly, Kamala D Patel, Subhadeep Chakrabarti, Erin McAvoy, Gary D Sinclair, Elizabeth M Keys, Emma Allen-Vercoe, Rebekah DeVinney, Christopher J Doig, Francis H Y Green & Paul Kubes Nature Medicine13, 463–469
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news and views Netting bacteria in sepsis
Constantin Urban & Arturo Zychlinsky Nature Medicine13, 403–404
(April 2007); doi:10.1038/nm0407-403
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letter A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
Chiea C Khor, Stephen J Chapman, Fredrik O Vannberg, Aisling Dunne, Caroline Murphy, Edmund Y Ling, Angela J Frodsham, Andrew J Walley, Otto Kyrieleis, Amir Khan, Christophe Aucan, Shelley Segal, Catrin E Moore, Kyle Knox, Sarah J Campbell, Christian Lienhardt, Anthony Scott, Peter Aaby, Oumou Y Sow, Robert T Grignani, Jackson Sillah, Giorgio Sirugo, Nobert Peshu, Thomas N Williams, Kathryn Maitland, Robert J O Davies, Dominic P Kwiatkowski, Nicholas P Day, Djamel Yala, Derrick W Crook, Kevin Marsh, James A Berkley, Luke A J O'Neill & Adrian V S Hill Nature Genetics39, 523–528
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article Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes
Jane A Skok, Ramiro Gisler, Maria Novatchkova, Deborah Farmer, Wouter de Laat & Meinrad Busslinger Nature Immunology8, 378–387
(April 2007); doi:10.1038/ni1448
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article Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
Lisa A Lesniewski, Sarah E Hosch, Jaap G Neels, Carl de Luca, Mohammad Pashmforoush, Carey N Lumeng, Shian-Huey Chiang, Miriam Scadeng, Alan R Saltiel & Jerrold M Olefsky Nature Medicine13, 455–462
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letter Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin
Kazuhiro Suzuki, Tatsusada Okuno, Midori Yamamoto, R. Jeroen Pasterkamp, Noriko Takegahara, Hyota Takamatsu, Tomoe Kitao, Junichi Takagi, Paul D. Rennert, Alex L. Kolodkin, Atsushi Kumanogoh & Hitoshi Kikutani Nature446, 680–684
(5 April 2007); doi:10.1038/nature05652
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letter Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada & Shimon Sakaguchi Nature446, 685–689
(5 April 2007); doi:10.1038/nature05673
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letter Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
Jun-Li Luo, Wei Tan, Jill M. Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L. Gonias, David A. Cheresh & Michael Karin Nature446, 690–694
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article Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
Carolina Jancic, Ariel Savina, Christina Wasmeier, Tanya Tolmachova, Jamel El-Benna, Pham My-Chan Dang, Steve Pascolo, Maire-Anne Gougerot-Pocidalo, Graça Raposo, Miguel C. Seabra & Sebastian Amigorena Nature Cell Biology9, 367–378
(April 2007); doi:10.1038/ncb1552
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news and views New ways to arrest phagosome maturation
David G. Russell Nature Cell Biology9, 357–359
(April 2007); doi:10.1038/ncb0407-357
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article Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor
Lu Deng, Ries J Langley, Patrick H Brown, Gang Xu, Leslie Teng, Qian Wang, Monica I Gonzales, Glenda G Callender, Michael I Nishimura, Suzanne L Topalian & Roy A Mariuzza Nature Immunology8, 398–408
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review Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
Kirsty C. Newman & Eleanor M. Riley Nature Reviews Immunology7, 279–291
(April 2007); doi:10.1038/nri2057
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March
letter Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
Colby Zaph, Amy E. Troy, Betsy C. Taylor, Lisa D. Berman-Booty, Katherine J. Guild, Yurong Du, Evan A. Yost, Achim D. Gruber, Michael J. May, Florian R. Greten, Lars Eckmann, Michael Karin & David Artis Nature446, 552–556
(29 March 2007); doi:10.1038/nature05590
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letter Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F. Neurath & Manolis Pasparakis Nature446, 557–561
(29 March 2007); doi:10.1038/nature05698
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letter DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
Hekla Sigmundsdottir, Junliang Pan, Gudrun F Debes, Carsten Alt, Aida Habtezion, Dulce Soler & Eugene C Butcher Nature Immunology8, 285–293
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perspective The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
Arne N. Akbar, Milica Vukmanovic-Stejic, Leonie S. Taams and Derek C. Macallan Nature Reviews Immunology7, 231–237
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article IFN-γ mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy
Vanessa Berner, Haiyan Liu, Qing Zhou, Kory L Alderson, Kai Sun, Jonathan M Weiss, Timothy C Back, Dan L Longo, Bruce R Blazar, Robert H Wiltrout, Lisbeth A Welniak, Doug Redelman & William J Murphy Nature Medicine13, 354–360
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news and views Vaccine leads to memory loss
John B A G Haanen & Ton N M Schumacher Nature Medicine13, 248–250
(March 2007); doi:10.1038/nm0307-248
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article Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
Phil Oh, Per Borgström, Halina Witkiewicz, Yan Li, Bengt J Borgström, Adrian Chrastina, Koji Iwata, Kurt R Zinn, Richard Baldwin, Jacqueline E Testa & Jan E Schnitzer Nature Biotechnology25, 327–337
(March 2007); doi:10.1038/nbt1292
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article Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI
Weifeng Xu, Bing He, April Chiu, Amy Chadburn, Meimei Shan, Malwina Buldys, Aihao Ding, Daniel M Knowles, Paul A Santini & Andrea Cerutti Nature Immunology8, 294–303
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news and views Local sentries for class switching
Michael McHeyzer-Williams Nature Immunology8, 230–232
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article Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4
Rudi Vennekens, Jenny Olausson, Marcel Meissner, Wilhelm Bloch, Ilka Mathar, Stephan E Philipp, Frank Schmitz, Petra Weissgerber, Bernd Nilius, Veit Flockerzi & Marc Freichel Nature Immunology8, 312–320
(March 2007); doi:10.1038/ni1441
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commentary CC chemokines and protective immunity: insights gained from mother-to-child transmission of HIV
Caroline T Tiemessen & Louise Kuhn Nature Immunology8, 219–222
(March 2007); doi:10.1038/ni0307-219
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review Cooperation of Toll-like receptor signals in innate immune defence
Giorgio Trinchieri and Alan Sher Nature Reviews Immunology7, 179–190
(March 2007); doi:10.1038/nri2038
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review Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential
Kenneth Dorshkind and Encarnacion Montecino-Rodriguez Nature Reviews Immunology7, 213–219
(March 2007); doi:10.1038/nri2019
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letter Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre
Joanna Krzemien, Laurence Dubois, Rami Makki, Marie Meister, Alain Vincent and Michèle Crozatier Nature446, 325–328
(15 March 2007); doi:10.1038/nature05650
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article A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule
Fleur E Tynan, Hugh H Reid, Lars Kjer-Nielsen, John J Miles, Matthew C J Wilce, Lyudmila Kostenko, Natalie A Borg, Nicholas A Williamson, Travis Beddoe, Anthony W Purcell, Scott R Burrows, James McCluskey & Jamie Rossjohn Nature Immunology8, 268–276
(March 2007); doi:10.1038/ni1432
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article Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4
Mickaël M Ménager, Gaël Ménasché, Maryse Romao, Perrine Knapnougel, Chen-Hsuan Ho, Mériem Garfa, Graça Raposo, Jérôme Feldmann, Alain Fischer & Geneviève de Saint Basile Nature Immunology8, 257–267
(March 2007); doi:10.1038/ni1431
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article Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Luke M Williams & Alexander Y Rudensky Nature Immunology8, 277–284
(March 2007); doi:10.1038/ni1437
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news and views Regulatory T-cell development: is Foxp3 the decider?
Tyler J Curiel Nature Medicine13, 250–253
(March 2007); doi:10.1038/nm0307-250
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news and views Cracking the cytokine code in psoriasis
Brian J Nickoloff Nature Medicine13, 242–244
(March 2007); doi:10.1038/nm0307-242
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news and views Skin safety
Charlotte Schubert Nature Medicine13, 244
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scientific report Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2
Qiaozhu Su, Shuo Wang, Dionissios Baltzis, Li-Ke Qu, Jennifer F Raven, Suiyang Li, Andrew Hoi-Tao Wong & Antonis E Koromilas EMBO reports8, 265 – 270
(March 2007); doi:10.1038/sj.embor.7400891
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letter C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
Nien-Jung Chen, Christine Mirtsos, Daniel Suh, Yong-Chen Lu, Wen-Jye Lin, Colin McKerlie, Taeweon Lee, Helene Baribault, Hui Tian and Wen-Chen Yeh Nature446, 203–207
(8 March 2007); doi:10.1038/nature05559
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review MAPK phosphatases — regulating the immune response
Yusen Liu, Edward G. Shepherd and Leif D. Nelin Nature Reviews Immunology7, 202–212
(March 2007); doi:10.1038/nri2035
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article The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
Youcun Qian, Caini Liu, Justin Hartupee, Cengiz Zubeyir Altuntas, Muhammet Fatih Gulen, Daniel Jane-wit, Jianhua Xiao, Yi Lu, Natalia Giltiay, Jinbo Liu, Tomasz Kordula, Qi-Wei Zhang, Bruce Vallance, Shadi Swaidani, Mark Aronica, Vincent K Tuohy, Thomas Hamilton & Xiaoxia Li Nature Immunology8, 247–256
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news and views Act1-ivating IL-17 inflammation
Christopher A Hunter Nature Immunology8, 232–234
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review The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Arlene H Sharpe, E John Wherry, Rafi Ahmed & Gordon J Freeman Nature Immunology8, 239–245
(March 2007); doi:10.1038/ni1443
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review PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?
Christian Rommel, Montserrat Camps and Hong Ji Nature Reviews Immunology7, 191–201
(March 2007); doi:10.1038/nri2036
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February
letter Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Alexander Marson, Karsten Kretschmer, Garrett M. Frampton, Elizabeth S. Jacobsen, Julia K. Polansky, Kenzie D. MacIsaac, Stuart S. Levine, Ernest Fraenkel, Harald von Boehmer and Richard A. Young Nature445, 931–935
(22 February 2007); doi:10.1038/nature05478
| First Paragraph | Full Text (HTML / PDF) |
article Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
Ivana M Djuretic, Ditsa Levanon, Varda Negreanu, Yoram Groner, Anjana Rao & K Mark Ansel Nature Immunology8, 145–153
(February 2007); doi:10.1038/ni1424
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article B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation
Carsten Krieg, Onur Boyman, Yang-Xin Fu & Jonathan Kaye Nature Immunology8, 162–171
(February 2007); doi:10.1038/ni1418
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review Interleukin-7 receptor expression: intelligent design
Renata Mazzucchelli and Scott K. Durum Nature Reviews Immunology7, 144–154
(February 2007); doi:10.1038/nri2023
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perspective Activating and inhibitory functions of DAP12
Isaiah R. Turnbull and Marco Colonna Nature Reviews Immunology7, 155–161
(February 2007); doi:10.1038/nri2014
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letter Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng, Dimitry M. Danilenko, Patricia Valdez, Ian Kasman, Jeffrey Eastham-Anderson, Jianfeng Wu and Wenjun Ouyang Nature445, 648–651
(15 February 2007); doi:10.1038/nature05505
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review Key factors in the organized chaos of early T cell development
Adrian C Hayday & Daniel J Pennington Nature Immunology8, 137–144
(February 2007); doi:10.1038/ni1436
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news and views The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
Yen-Michael S Hsu, Yongliang Zhang, Yun You, Donghai Wang, Hongxiu Li, Omar Duramad, Xiao-Feng Qin, Chen Dong & Xin Lin Nature Immunology8, 198–205
(February 2007); doi:10.1038/ni1426
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news and views A pair of 9s: it's in the CARDs
David M Underhill & Takahiro Shimada Nature Immunology8, 122–124
(February 2007); doi:10.1038/ni0207-122
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review Transcription factors in myeloid development: balancing differentiation with transformation
Frank Rosenbauer and Daniel G. Tenen Nature Reviews Immunology7, 105–117
(February 2007); doi:10.1038/nri2024
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article Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors
June L Round, Lisa A Humphries, Tamar Tomassian, Paul Mittelstadt, Min Zhang & M Carrie Miceli Nature Immunology8, 154–161
(February 2007); doi:10.1038/ni1422
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news and views Choreography of MAGUKs during T cell activation
Mercedes Rincón & Roger J Davis Nature Immunology8, 126–127
(February 2007); doi:10.1038/ni0207-126
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review Regulation of T-cell activation by the cytoskeleton
Daniel D. Billadeau, Jeffrey C. Nolz and Timothy S. Gomez Nature Reviews Immunology7, 131–143
(February 2007); doi:10.1038/nri2021
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January
letter Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin
Fan Pan, Luo Sun, David B. Kardian, Katharine A. Whartenby, Drew M. Pardoll and Jun O. Liu Nature445, 433–436
(25 January 2007); doi:10.1038/nature05476
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review The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes
Jianxun Song, Shahram Salek-Ardakani, Takanori So & Michael Croft Nature Immunology8, 64–73
(January 2007); doi:10.1038/ni1413
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article Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid, Antoine Tesniere, François Ghiringhelli, Gian Maria Fimia, Lionel Apetoh, Jean-Luc Perfettini, Maria Castedo, Grégoire Mignot, Theoharis Panaretakis, Noelia Casares, Didier Métivier, Nathanael Larochette, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini, Laurence Zitvogel & Guido Kroemer Nature Medicine13, 54–61
(January 2007); doi:10.1038/nm1523
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article Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
Bruce T Seet, Donna M Berry, Jonathan S Maltzman, Jacob Shabason, Monica Raina, Gary A Koretzky, C Jane McGlade and Tony Pawson The EMBO JournalAOP,
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article Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
Ewen Gallagher, Thomas Enzler, Atsushi Matsuzawa, Amy Anzelon-Mills, Dennis Otero, Ryan Holzer, Edith Janssen, Min Gao & Michael Karin Nature Immunology8, 57–63
(January 2007); doi:10.1038/ni1421
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review T-cell regulation: with complements from innate immunity
Claudia Kemper and John P. Atkinson Nature Reviews Immunology7, 9–18
(January 2007); doi:10.1038/nri1994
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article Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia
Tomas Vilimas, Joaquina Mascarenhas, Teresa Palomero, Malay Mandal, Silvia Buonamici, Fanyong Meng, Benjamín Thompson, Christina Spaulding, Sami Macaroun, Maria-Luisa Alegre, Barbara L Kee, Adolfo Ferrando, Lucio Miele & Iannis Aifantis Nature Medicine13, 70–77
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article An injected bacterial effector targets chromatin access for transcription factor NF-κB to alter transcription of host genes involved in immune responses
Laurence Arbibe, Dong Wook Kim, Eric Batsche, Thierry Pedron, Bogdan Mateescu, Christian Muchardt, Claude Parsot & Philippe J Sansonetti Nature Immunology8, 47–56
(January 2007); doi:10.1038/ni1423
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article Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses
Jr-Wen Shui, Jonathan S Boomer, Jin Han, Jun Xu, Gregory A Dement, Guisheng Zhou & Tse-Hua Tan Nature Immunology8, 84–91
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review Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Hua Yu, Marcin Kortylewski and Drew Pardoll Nature Reviews Immunology7, 41–51
(January 2007); doi:10.1038/nri1995
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letter A systems biology analysis of the Drosophila phagosome
L. M. Stuart, J. Boulais, G. M. Charriere, E. J. Hennessy, S. Brunet, I. Jutras, G. Goyette, C. Rondeau, S. Letarte, H. Huang, P. Ye, F. Morales, C. Kocks, J. S. Bader, M. Desjardins and R. A. B. Ezekowitz Nature445, 95–101
(4 January 2007); doi:10.1038/nature05380
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review Integrating cell-signalling pathways with NF-κB and IKK function
Neil D. Perkins Nature Reviews Molecular Cell Biology8, 49–62
(January 2007); doi:10.1038/nrm2083
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article Dectin-1 is required for β-glucan recognition and control of fungal infection
Philip R Taylor, S Vicky Tsoni, Janet A Willment, Kevin M Dennehy, Marcela Rosas, Helen Findon, Ken Haynes, Chad Steele, Marina Botto, Siamon Gordon & Gordon D Brown Nature Immunology8, 31–38
(January 2007); doi:10.1038/ni1408
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article Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
Shinobu Saijo, Noriyuki Fujikado, Takahisa Furuta, Soo-hyun Chung, Hayato Kotaki, Keisuke Seki, Katsuko Sudo, Shizuo Akira, Yoshiyuki Adachi, Naohito Ohno, Takeshi Kinjo, Kiwamu Nakamura, Kazuyoshi Kawakami & Yoichiro Iwakura Nature Immunology8, 39–46
(January 2007); doi:10.1038/ni1425
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news and views DEteCTINg fungal pathogens
Catherine Dostert & Jürg Tschopp Nature Immunology8, 17–18
(January 2007); doi:10.1038/ni0107-17
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review Notch signalling during peripheral T-cell activation and differentiation
Barbara A. Osborne and Lisa M. Minter Nature Reviews Immunology7, 64–75
(January 2007); doi:10.1038/nri1998
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