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Research library: Immunology

2009: | December | November | October | September | August | July | June | May | April | March | February | January

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article
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
Fuping You et al.
Nature Immunology 10, 1300–1308
(December 2009); doi:10.1038/ni.1815
| Summary | Full Text (HTML / PDF) |

review
Naive T cell homeostasis: from awareness of space to a sense of place
Kensuke Takada & Stephen C. Jameson
Nature Reviews Immunology 9, 823–832
(December 2009); doi:10.1038/nri2657
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article
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
Katrina L Randall et al.
Nature Immunology 10, 1283–1291
(December 2009); doi:10.1038/ni.1820
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article
Multiple layers of B cell memory with different effector functions
Ismail Dogan et al.
Nature Immunology 10, 1292–1299
(December 2009); doi:10.1038/ni.1814
| Summary | Full Text (HTML / PDF) |

news and views
B cell memory: how to start and when to end
Nadege Pelletier & Michael G McHeyzer-Williams
Nature Immunology 10, 1233–1235
(December 2009); doi:10.1038/ni1209-1233
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article
T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
Michael H Shaw et al.
Nature Immunology 10, 1267–1274
(December 2009); doi:10.1038/ni.1816
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news and views
T cells need Nod too?
Shahram Salek-Ardakani & Michael Croft
Nature Immunology 10, 1231–1233
(December 2009); doi:10.1038/ni1209-1231
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article
Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels
Mithilesh K Jha et al.
Nature Immunology 10, 1275–1282
(December 2009); doi:10.1038/ni.1793
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article
Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template
Smadar Cohen-Chalamish et al.
Nature Chemical Biology 5, 896–903
(December 2009); doi:10.1038/nchembio.234
| Summary | Full Text (HTML / PDF) |

letter
Central control of fever and female body temperature by RANKL/RANK
Reiko Hanada et al.
Nature 462, 505–509
(26 November 2009); doi:10.1038/nature08596
| Full Text (HTML / PDF) |

article
Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
Dipayan Rudra et al.
Nature Immunology 10, 1170–1177
(November 2009); doi:10.1038/ni.1795
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article
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
Masako Murai et al.
Nature Immunology 10, 1178–1184
(November 2009); doi:10.1038/ni.1791
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news and views
The gut feeling of Treg cells: IL-10 is the silver lining during colitis
Derya Unutmaz & Bali Pulendran
Nature Immunology 10, 1141–1143
(November 2009); doi:10.1038/ni1109-1141
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review
Analysing immune cell migration
Joost B. Beltman, Athanasius F. M. Marée & Rob J. de Boer
Nature Reviews Immunology 9, 789–798
(November 2009); doi:10.1038/nri2638
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article
PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance
Lata Mukundan et al.
Nature Medicine 15, 1266–1272
(November 2009); doi:10.1038/nm.2048
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news and views
Autoimmunity: apoptotic fats grease transcription
Keith B Elkon
Nature Medicine 15, 1246–1248
(November 2009); doi:10.1038/nm1109-1246
| Full Text (HTML / PDF) |

review
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu, Drew Pardoll & Richard Jove
Nature Reviews Cancer 9, 798–809
(November 2009); doi:10.1038/nrc2734
| Summary | Full Text (HTML / PDF) |

brief communication
Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein
Zhiru Yang, Anthony P West & Pamela J Bjorkman
Nature Structural & Molecular Biology 16, 1189–1191
(November 2009); doi:10.1038/nsmb.1683
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article
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
Brian T Fife et al.
Nature Immunology 10, 1185–1192
(November 2009); doi:10.1038/ni.1790
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review
Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases
Manolis Pasparakis
Nature Reviews Immunology 9, 778–788
(November 2009); doi:10.1038/nri2655
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article
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
Roman Barbalat, Laura Lau, Richard M Locksley & Gregory M Barton
Nature Immunology 10, 1200–1207
(November 2009); doi:10.1038/ni.1792
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news and views
TLR2 joins the interferon gang
Franz Bauernfeind & Veit Hornung
Nature Immunology 10, 1139–1141
(November 2009); doi:10.1038/ni1109-1139
| Full Text (HTML / PDF) |

article
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
Serge A van de Pavert et al.
Nature Immunology 10, 1193–1199
(November 2009); doi:10.1038/ni.1789
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article
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines
Ashley L St John & Soman N Abraham
Nature Medicine 15, 1259–1265
(November 2009); doi:10.1038/nm.2036
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letter
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
Hideyuki Yanai et al.
Nature 462, 99–103
(05 November 2009); doi:10.1038/nature08512
| Full Text (HTML / PDF) |

article
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells
Wan-Lin Lo et al.
Nature Immunology 10, 1155–1161
(November 2009); doi:10.1038/ni.1796
| Summary | Full Text (HTML / PDF) |

article
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
Peter J R Ebert, Shan Jiang, Jianming Xie, Qi-Jing Li & Mark M Davis
Nature Immunology 10, 1162–1169
(November 2009); doi:10.1038/ni.1797
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news and views
Positively selecting peptides: their job does not end in the thymus
Kai W Wucherpfennig & Etienne Gagnon
Nature Immunology 10, 1143–1144
(November 2009); doi:10.1038/ni1109-1143
| Full Text (HTML / PDF) |

article
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex
Weihui Wu, Yen-Michael S Hsu, Liangkuan Bi, Zhou Songyang & Xin Lin
Nature Immunology 10, 1208–1214
(November 2009); doi:10.1038/ni.1788
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review
Intestinal mucosal barrier function in health and disease
Jerrold R. Turner
Nature Reviews Immunology 9, 799–809
(November 2009); doi:10.1038/nri2653
| Summary | Full Text (HTML / PDF) |

review
Protein denitrosylation: enzymatic mechanisms and cellular functions
Moran Benhar, Michael T. Forrester & Jonathan S. Stamler
Nature Reviews Molecular Cell Biology 10, 721–732
(October 2009); doi:10.1038/nrm2764
| Summary | Full Text (HTML / PDF) |

article
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
Duncan M Gascoyne et al.
Nature Immunology 10, 1118–1124
(October 2009); doi:10.1038/ni.1787
| Summary | Full Text (HTML / PDF) |

news and views
A defining factor for natural killer cell development
James P Di Santo
Nature Immunology 10, 1051–1052
(October 2009); doi:10.1038/ni1009-1051
| Full Text (HTML / PDF) |

review
Complement regulators and inhibitory proteins
Peter F. Zipfel & Christine Skerka
Nature Reviews Immunology 9, 729–740
(October 2009); doi:10.1038/nri2620
| Summary | Full Text (HTML / PDF) |

article
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
François Ghiringhelli et al.
Nature Medicine 15, 1170–1178
(October 2009); doi:10.1038/nm.2028
| Summary | Full Text (HTML / PDF) |

brief communication
Extracellular redox modulation by regulatory T cells
Zhonghua Yan, Sanjay K Garg, Jonathan Kipnis & Ruma Banerjee
Nature Chemical Biology 5, 721–723
(October 2009); doi:10.1038/nchembio.212
| Summary | Full Text (HTML / PDF) |

news and views
Chemo-metabolic regulation of immune responses by Tregs
Anna Rubartelli & Roberto Sitia
Nature Chemical Biology 5, 709–710
(October 2009); doi:10.1038/nchembio.226
| Full Text (HTML / PDF) |

article
Activation of innate immune antiviral responses by Nod2
Ahmed Sabbah et al.
Nature Immunology 10, 1073–1080
(October 2009); doi:10.1038/ni.1782
| Summary | Full Text (HTML / PDF) |

news and views
Beyond peptidoglycan for Nod2
Peter J Murray
Nature Immunology 10, 1053–1054
(October 2009); doi:10.1038/ni1009-1053
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review
Transcriptional control of the inflammatory response
Ruslan Medzhitov & Tiffany Horng
Nature Reviews Immunology 9, 692–703
(October 2009); doi:10.1038/nri2634
| Summary | Full Text (HTML / PDF) |

brief communication
Augmented photoswitching modulates immune signaling
Yixin Zhang, Frank Erdmann & Gunter Fischer
Nature Chemical Biology 5, 724–726
(October 2009); doi:10.1038/nchembio.214
| Summary | Full Text (HTML / PDF) |

article
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
Mikyoung Chang, Wei Jin & Shao-Cong Sun
Nature Immunology 10, 1089–1095
(October 2009); doi:10.1038/ni.1777
| Summary | Full Text (HTML / PDF) |

article
Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
Malay Mandal et al.
Nature Immunology 10, 1110–1117
(October 2009); doi:10.1038/ni.1785
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article
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
Marcin Kortylewski et al.
Nature Biotechnology 27, 925–932
(October 2009); doi:10.1038/nbt.1564
| Summary | Full Text (HTML / PDF) |

news and views
siRNA delivery not Toll-free
Michael P Gantier & Bryan R G Williams
Nature Biotechnology 27, 911–912
(October 2009); doi:10.1038/nbt1009-911
| Full Text (HTML / PDF) |

letter
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Hiroki Ishikawa, Zhe Ma & Glen N. Barber
Nature 461, 788–792
(08 October 2009); doi:10.1038/nature08476
| Full Text (HTML / PDF) |

article
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
Sonja I Gringhuis, Jeroen den Dunnen, Manja Litjens, Michiel van der Vlist & Teunis B H Geijtenbeek
Nature Immunology 10, 1081–1088
(October 2009); doi:10.1038/ni.1778
| Summary | Full Text (HTML / PDF) |

review
The cunning little vixen: Foxo and the cycle of life and death
Stephen M Hedrick
Nature Immunology 10, 1057–1063
(October 2009); doi:10.1038/ni.1784
| Summary | Full Text (HTML / PDF) |

review
Engineering lymphocyte subsets: tools, trials and tribulations
Carl H. June, Bruce R. Blazar & James L. Riley
Nature Reviews Immunology 9, 704–716
(October 2009); doi:10.1038/nri2635
| Summary | Full Text (HTML / PDF) |

brief communication
Augmented photoswitching modulates immune signaling
Yixin Zhang, Frank Erdmann & Gunter Fischer
Nature Chemical Biology 5, 724–726
(October 2009); doi:10.1038/nchembio.214
| Summary | Full Text (HTML / PDF) |

letter
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A. O’ Reilly et al.
Nature 461, 659–663
(01 October 2009); doi:10.1038/nature08402
| Full Text (HTML / PDF) |

article
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate
Andrea Ablasser et al.
Nature Immunology 10, 1065–1072
(October 2009); doi:10.1038/ni.1779
| Summary | Full Text (HTML / PDF) |

news and views
New DNA-sensing pathway feeds RIG-I with RNA
Xuetao Cao
Nature Immunology 10, 1049–1051
(October 2009); doi:10.1038/ni1009-1049
| Full Text (HTML / PDF) |

article
Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
Mauricio F Farez et al.
Nature Immunology 10, 958–964
(September 2009); doi:10.1038/ni.1775
| Summary | Full Text (HTML / PDF) |

article
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
Juan M Ilarregui et al.
Nature Immunology 10, 981–991
(September 2009); doi:10.1038/ni.1772
| Summary | Full Text (HTML / PDF) |

perspective
Signalling crosstalk in B cells: managing worth and need
Michael P. Cancro
Nature Reviews Immunology 9, 657–661
(September 2009); doi:10.1038/nri2621
| Summary | Full Text (HTML / PDF) |

article
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
Tatsukata Kawagoe et al.
Nature Immunology 10, 965–972
(September 2009); doi:10.1038/ni.1771
| Summary | Full Text (HTML / PDF) |

article
Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
Zhongjun Dong et al.
Nature Immunology 10, 973–980
(September 2009); doi:10.1038/ni.1763
| Summary | Full Text (HTML / PDF) |

review
Cytokine determinants of viral tropism
Grant McFadden, Mohamed R. Mohamed, Masmudur M. Rahman & Eric Bartee
Nature Reviews Immunology 9, 645–655
(September 2009); doi:10.1038/nri2623
| Summary | Full Text (HTML / PDF) |

article
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ
Qing Yu et al.
Nature Immunology 10, 992–999
(September 2009); doi:10.1038/ni.1762
| Summary | Full Text (HTML / PDF) |

review
Rho family GTPases and their regulators in lymphocytes
Victor L. J. Tybulewicz & Robert B. Henderson
Nature Reviews Immunology 9, 630–644
(September 2009); doi:10.1038/nri2606
| Summary | Full Text (HTML / PDF) |

letter
Direct activation of protein kinases by unanchored polyubiquitin chains
Zong-Ping Xia et al.
Nature 461, 114–119
(03 September 2009); doi:10.1038/nature08247
| Full Text (HTML / PDF) |

article
Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut
Eun-Mi Ha et al.
Nature Immunology 10, 949–957
(September 2009); doi:10.1038/ni.1765
| Summary | Full Text (HTML / PDF) |

news and views
Maintaining immune homeostasis in fly gut
François Leulier & Julien Royet
Nature Immunology 10, 936–938
(September 2009); doi:10.1038/ni0909-936
| Full Text (HTML / PDF) |

article
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells
Niklas Engels et al.
Nature Immunology 10, 1018–1025
(September 2009); doi:10.1038/ni.1764
| Summary | Full Text (HTML / PDF) |

review
Interdependence of hypoxic and innate immune responses
Victor Nizet & Randall S. Johnson
Nature Reviews Immunology 9, 609–617
(September 2009); doi:10.1038/nri2607
| Summary | Full Text (HTML / PDF) |

article
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria
Sangeeta Tiwari, Han-Pil Choi, Takeshi Matsuzawa, Marc Pypaert & John D MacMicking
Nature Immunology 10, 907–917
(August 2009); doi:10.1038/ni.1759
| Summary | Full Text (HTML / PDF) |

news and views
New insight into the everlasting host-pathogen arms race
Coenraad Kuijl & Jacques Neefjes
Nature Immunology 10, 808–809
(August 2009); doi:10.1038/ni0809-808
| Full Text (HTML / PDF) |

review
A cell biological view of Toll-like receptor function: regulation through compartmentalization
Gregory M. Barton & Jonathan C. Kagan
Nature Reviews Immunology 9, 535–542
(August 2009); doi:10.1038/nri2587
| Summary | Full Text (HTML / PDF) |

review
Therapeutic manipulation of immune tolerance in allergic disease
Mübeccel Akdis & Cezmi A. Akdis
Nature Reviews Drug Discovery 8, 645–660
(August 2009); doi:10.1038/nrd2653
| Summary | Full Text (HTML / PDF) |

article
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils
Kang Chen et al.
Nature Immunology 10, 889–898
(August 2009); doi:10.1038/ni.1748
| Summary | Full Text (HTML / PDF) |

review
Structure and signalling in the IL-17 receptor family
Sarah L. Gaffen
Nature Reviews Immunology 9, 556–567
(August 2009); doi:10.1038/nri2586
| Summary | Full Text (HTML / PDF) |

article
Essential function for the GTPase TC21 in homeostatic antigen receptor signaling
Pilar Delgado et al.
Nature Immunology 10, 880–888
(August 2009); doi:10.1038/ni.1749
| Summary | Full Text (HTML / PDF) |

review
Oncogenic stress sensed by the immune system: role of natural killer cell receptors
David H. Raulet & Nadia Guerra
Nature Reviews Immunology 9, 568–580
(August 2009); doi:10.1038/nri2604
| Summary | Full Text (HTML / PDF) |

letter
Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury
Takashi Shichita et al.
Nature Medicine 15, 946–950
(August 2009); doi:10.1038/nm.1999
| Summary | Full Text (HTML / PDF) |

news and views
T time in the brain
Eng H Lo
Nature Medicine 15, 844–846
(August 2009); doi:10.1038/nm0809-844
| Full Text (HTML / PDF) |

letter
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
Nature Cell Biology 11, 973–979
(August 2009); doi:10.1038/ncb1909
| Summary | Full Text (HTML / PDF) |

news and views
SASPense and DDRama in cancer and ageing
Marzia Fumagalli & Fabrizio d'Adda di Fagagna
Nature Cell Biology 11, 921–923
(August 2009); doi:10.1038/ncb0809-921
| Full Text (HTML / PDF) |

article
A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis
Manikuntala Kundu et al.
Nature Immunology 10, 918–926
(August 2009); doi:10.1038/ni.1754
| Summary | Full Text (HTML / PDF) |

review
Mechanisms and functions for the duration of intercellular contacts made by lymphocytes
Daniel M. Davis
Nature Reviews Immunology 9, 543–555
(August 2009); doi:10.1038/nri2602
| Summary | Full Text (HTML / PDF) |

letter
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
Ulf Schulze-Topphoff et al.
Nature Medicine 15, 788–793
(July 2009); doi:10.1038/nm.1980
| Summary | Full Text (HTML / PDF) |

letter
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
Luca Gattinoni et al.
Nature Medicine 15, 808–813
(July 2009); doi:10.1038/nm.1982
| Summary | Full Text (HTML / PDF) |

news and views
Tumor immunotherapy: making an immortal army
Brent H. Koehn & Stephen P. Schoenberger
Nature Medicine 15, 731–732
(July 2009); doi:10.1038/nm0709-731
| Full Text (HTML / PDF) |

article
Adenosine A2A receptor mediates microglial process retraction
Anna G Orr, Adam L Orr, Xiao-Jiang Li, Robert E Gross & Stephen F Traynelis
Nature Neuroscience 12, 872–878
(July 2009); doi:10.1038/nn.2341
| Summary | Full Text (HTML / PDF) |

letter
Regulation of the innate immune response by threonine-phosphatase of Eyes absent
Yasutaka Okabe, Teruyuki Sano & Shigekazu Nagata
Nature 460, 520–524
(23 July 2009); doi:10.1038/nature08138
| Full Text (HTML / PDF) |

article
Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells
Lorena Riol-Blanco et al.
Nature Immunology 10, 753–760
(July 2009); doi:10.1038/ni.1750
| Summary | Full Text (HTML / PDF) |

review
New insights into the regulation of T cells by γc family cytokines
Yrina Rochman, Rosanne Spolski & Warren J. Leonard
Nature Reviews Immunology 9, 480–490
(July 2009); doi:10.1038/nri2580
| Summary | Full Text (HTML / PDF) |

letter
Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
Yorihiro Nishimura et al.
Nature Medicine 15, 794–797
(July 2009); doi:10.1038/nm.1961
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letter
Scavenger receptor B2 is a cellular receptor for enterovirus 71
Seiya Yamayoshi et al.
Nature Medicine 15, 798–801
(July 2009); doi:10.1038/nm.1992
| Summary | Full Text (HTML / PDF) |

news and views
Receptors identified for hand, foot and mouth virus
Kunal P. Patel & Jeffrey M. Bergelson
Nature Medicine 15, 728–729
(July 2009); doi:10.1038/nm0709-728
| Full Text (HTML / PDF) |

letter
The AP-1 transcription factor Batf controls TH17 differentiation
Barbara U. Schraml et al.
Nature 460, 405–409
(16 July 2009); doi:10.1038/nature08114
| Full Text (HTML / PDF) |

article
Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin
Karel Otero et al.
Nature Immunology 10, 734–743
(July 2009); doi:10.1038/ni.1744
| Summary | Full Text (HTML / PDF) |

news and views
CSF-1R, DAP12 and β-catenin: a ménage à trois
Daniel W McVicar & Giorgio Trinchieri
Nature Immunology 10, 681–683
(July 2009); doi:10.1038/ni0709-681
| Full Text (HTML / PDF) |

review
CD95, BIM and T cell homeostasis
Philippe Bouillet & Lorraine A. O'Reilly
Nature Reviews Immunology 9, 514–519
(July 2009); doi:10.1038/nri2570
| Summary | Full Text (HTML / PDF) |

article
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
Tony Muchamuel et al.
Nature Medicine 15, 781–787
(July 2009); doi:10.1038/nm.1978
| Summary | Full Text (HTML / PDF) |

letter
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
Ivan Zanoni et al.
Nature 460, 264–268
(09 July 2009); doi:10.1038/nature08118
| Full Text (HTML / PDF) |

letter
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
Greta Guarda et al.
Nature 460, 269–273
(09 July 2009); doi:10.1038/nature08100
| Full Text (HTML / PDF) |

article
The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
Guangwei Liu et al.
Nature Immunology 10, 769–777
(July 2009); doi:10.1038/ni.1743
| Summary | Full Text (HTML / PDF) |

news and views
A novel modifier of regulatory T cells
Naganari Ohkura & Shimon Sakaguchi
Nature Immunology 10, 685–686
(July 2009); doi:10.1038/ni0709-685
| Full Text (HTML / PDF) |

article
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
Chen Wang et al.
Nature Immunology 10, 744–752
(July 2009); doi:10.1038/ni.1742
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review
Cracking the BAFF code
Fabienne Mackay & Pascal Schneider
Nature Reviews Immunology 9, 491–502
(July 2009); doi:10.1038/nri2572
| Summary | Full Text (HTML / PDF) |

letter
Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase
Nisheeth Agarwal, Gyanu Lamichhane, Radhika Gupta, Scott Nolan & William R. Bishai
Nature 460, 98–102
(02 July 2009); doi:10.1038/nature08123
| Full Text (HTML / PDF) |

letter
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
Nature 460, 103–107
(02 July 2009); doi:10.1038/nature08097
| Full Text (HTML / PDF) |

letter
mTOR regulates memory CD8 T-cell differentiation
Koichi Araki et al.
Nature 460, 108–112
(02 July 2009); doi:10.1038/nature08155
| Full Text (HTML / PDF) |

news and views
Immunology: A metabolic switch to memory
Martin Prlic & Michael J. Bevan
Nature 460, 41–42
(02 July 2009); doi:10.1038/460041a
| Full Text (HTML / PDF) |

article
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
Suzan H M Rooijakkers et al.
Nature Immunology 10, 721–727
(July 2009); doi:10.1038/ni.1756
| Summary | Full Text (HTML / PDF) |

article
Structure of complement fragment C3b–factor H and implications for host protection by complement regulators
Jin Wu et al.
Nature Immunology 10, 728–733
(July 2009); doi:10.1038/ni.1755
| Summary | Full Text (HTML / PDF) |

review
Signalling through C-type lectin receptors: shaping immune responses
Teunis B. H. Geijtenbeek & Sonja I. Gringhuis
Nature Reviews Immunology 9, 465–479
(July 2009); doi:10.1038/nri2569
| Summary | Full Text (HTML / PDF) |

article
Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals
Emmanuel Derudder et al.
Nature Immunology 10, 647–654
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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
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Nature Immunology 10, 655–664
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Narcolepsy is strongly associated with the T-cell receptor alpha locus
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Nature Genetics 41, 708–711
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Narcolepsy and the T-cell receptor
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Nature Genetics 41, 640–641
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Unleashing the therapeutic potential of NOD-like receptors
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Nature Reviews Drug Discovery 8, 465–479
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Nature Structural & Molecular Biology 16, 658–666
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Roles of galectins in infection
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Nature Reviews Microbiology 7, 424–438
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A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
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Nature 459, 996–999
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Inflammation: Wound healing in zebrafish
Paul Martin & Yi Feng
Nature 459, 921–923
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CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
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Nature 459, 1000–1004
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A protective function for interleukin 17A in T cell–mediated intestinal inflammation
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Nature Immunology 10, 603–609
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IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation
Amit Awasthi & Vijay K Kuchroo
Nature Immunology 10, 568–570
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Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
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Nature Immunology 10, 587–594
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Targeting innate immunity protein kinase signalling in inflammation
Matthias Gaestel, Alexey Kotlyarov & Michael Kracht
Nature Reviews Drug Discovery 8, 480–499
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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
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Nature Immunology 10, 595–602
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Hybrid Treg cells: steel frames and plastic exteriors
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Nature Immunology 10, 563–564
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Autoimmune T cell responses in the central nervous system
Joan Goverman
Nature Reviews Immunology 9, 393–407
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Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
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Nature Medicine 15, 633–640
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TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway
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Nature Immunology 10, 579–586
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Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells
Emily J Quann, Ernesto Merino, Toshiaki Furuta & Morgan Huse
Nature Immunology 10, 627–635
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Regulation of innate immune responses in the brain
Serge Rivest
Nature Reviews Immunology 9, 429–439
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Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells
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Nature Immunology 10, 504–513
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The Foxo and the hound: chasing the in vivo regulation of T cell populations during infection
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Nature Immunology 10, 457–458
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Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
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Nature Reviews Immunology 9, 338–352
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Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
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Nature Medicine 15, 528–536
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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
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Nature 459, 433–436
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Nature Immunology 10, 531–539
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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
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Nature Medicine 15, 545–552
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Blood pressure control: salt gets under your skin
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Nature Medicine 15, 487–488
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Do symbiotic bacteria subvert host immunity?
Lora V. Hooper
Nature Reviews Microbiology 7, 367–374
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Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma
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Nature Immunology 10, 496–503
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Nature Chemical Biology 5, 308–316
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C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
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Nature Immunology 10, 514–523
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Gaining entry to an uninflamed brain
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Nature Immunology 10, 453–455
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Immunoregulatory functions of mTOR inhibition
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Nature Reviews Immunology 9, 324–337
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Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain
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Nature Medicine 15, 519–527
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Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay
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Nature 458, 1185–1190
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The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
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Nature 458, 1191–1195
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A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
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Nature Immunology 10, 471–479
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Crohn's disease-associated Nod2 mutants reduce IL10 transcription
Dana J Philpott & Stephen E Girardin
Nature Immunology 10, 455–457
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Immunogenic and tolerogenic cell death
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Nature Reviews Immunology 9, 353–363
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Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
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Nature Immunology 10, 420–426
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AID and RPA: PKA makes the connection local
Cristina Rada
Nature Immunology 10, 367–369
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Nature Immunology 10, 333–339
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Antiviral immune responses: triggers of or triggered by autoimmunity?
Christian Münz, Jan D. Lünemann, Meghann Teague Getts & Stephen D. Miller
Nature Reviews Immunology 9, 246–258
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scientific report
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway
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Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
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Nature 458, 899–903
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Cross-regulation of signaling by ITAM-associated receptors
Lionel B Ivashkiv
Nature Immunology 10, 340–347
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perspective
Lymphocyte signaling: beyond knockouts
Alexander Saveliev & Victor L J Tybulewicz
Nature Immunology 10, 361–364
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The role of TNF superfamily members in T-cell function and diseases
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Nature Reviews Immunology 9, 271–285
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Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity
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Nature Medicine 15, 401–409
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Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
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Nature Immunology 10, 403–411
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perspective
Selectivity and therapeutic inhibition of kinases: to be or not to be?
Kamran Ghoreschi, Arian Laurence & John J O'Shea
Nature Immunology 10, 356–360
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Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
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Nature Medicine 15, 384–391
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Neutrophil sandwiches injure the microcirculation
Mark R Looney & Michael A Matthay
Nature Medicine 15, 364–366
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Nature Medicine 15, 410–416
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Dust mites' dirty dealings in the lung
Clare M Lloyd
Nature Medicine 15, 366–367
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Death receptor signal transducers: nodes of coordination in immune signaling networks
Nicholas S Wilson, Vishva Dixit & Avi Ashkenazi
Nature Immunology 10, 348–355
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Genetic architecture of mouse skin inflammation and tumour susceptibility
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Nature 458, 505–508
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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
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Nature 458, 509–513
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Nature 458, 514–518
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Dynamic expression of epidermal caspase 8 simulates a wound healing response
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Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
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Nature Immunology 10, 297–305
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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
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Antiviral immunity in Drosophila requires systemic RNA interference spread
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Nature 458, 346–350
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Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
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The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells
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Nature Immunology 10, 306–313
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Developing NKT cells need their calcium
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Nature Immunology 10, 231–233
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Nature Reviews Immunology 9, 195–205
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How (and why) the immune system makes us sleep
Luca Imeri & Mark R. Opp
Nature Reviews Neuroscience 10, 199–210
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The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling
Noula Shembade, Kislay Parvatiyar, Nicole S Harhaj & Edward W Harhaj
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Complete but curtailed T-cell response to very low-affinity antigen
Dietmar Zehn, Sarah Y. Lee & Michael J. Bevan
Nature 458, 211–214
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Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-β signaling pathway in Caenorhabditis elegans epidermis
Olivier Zugasti & Jonathan J Ewbank
Nature Immunology 10, 249–256
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Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
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Nature Immunology 10, 273–280
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A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
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Nature Medicine 15, 313–318
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Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells
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Nature Medicine 15, 300–305
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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
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Nature Medicine 15, 306–312
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When integrins fail to integrate
Andrés Hidalgo & Paul S Frenette
Nature Medicine 15, 249–250
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The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
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Nature Immunology 10, 257–265
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Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c
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Nature Immunology 10, 289–296
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Deciding the decider: Mef2c in hematopoiesis
Rachel M Gerstein
Nature Immunology 10, 235–236
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Ca2+/calmodulin regulates salicylic-acid-mediated plant immunity
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Nature 457, 1154–1158
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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
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Nature Immunology 10, 176–184
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Homeostasis of naive T cells: the Foxo that fixes
Antonio A Freitas & Benedita Rocha
Nature Immunology 10, 133–134
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Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
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Nature Medicine 15, 206–210
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Pyroptosis: host cell death and inflammation
Tessa Bergsbaken, Susan L. Fink & Brad T. Cookson
Nature Reviews Microbiology 7, 99–109
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Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
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Nature Immunology 10, 149–157
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Niche marketing: regulation of the homeostasis of naive CD4+ T cells
Jonathan Kaye
Nature Immunology 10, 136–138
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The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells
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Nature Immunology 10, 158–166
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Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
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Nature Medicine 15, 192–199
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Regulatory T cells protect the brain after stroke
Anna M Planas & Angel Chamorro
Nature Medicine 15, 138–139
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Nature Immunology 10, 203–213
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Nature Immunology 10, 185–194
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NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+-sirtuin-1-dependent pathway
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Nature Medicine 15, 151–158
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Vitamin B3 boosts neutrophil counts
Arati Khanna-Gupta & Nancy Berliner
Nature Medicine 15, 139–141
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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
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The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
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Scaffold proteins and immune-cell signalling
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Nature Reviews Immunology 9, 47–56
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Toll-like receptors and cancer
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Nature Reviews Cancer 9, 57–63
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Nature Immunology 10, 29–37
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Nature Immunology 10, 38–47
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Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
Mauro Perretti & Fulvio D'Acquisto
Nature Reviews Immunology 9, 62–70
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Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility
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Nature Cell Biology 11, 17–26
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Undressing a cellular corset: septins exposed
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Nature Cell Biology 11, 9–10
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ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
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Nature Immunology 10, 109–115
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A new function for the RNA-editing enzyme ADAR1
Hisashi Iizasa & Kazuko Nishikura
Nature Immunology 10, 16–18
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Calcium signaling in immune cells
Monika Vig & Jean-Pierre Kinet
Nature Immunology 10, 21–27
(January 2009); doi:10.1038/ni.f.220
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review
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Alexandra Zhernakova, Cleo C. van Diemen & Cisca Wijmenga
Nature Reviews Genetics 10, 43–55
(January 2009); doi:10.1038/nrg2489
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letter
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
Jiyun V. Kim, Silvia S. Kang, Michael L. Dustin & Dorian B. McGavern
Nature 457, 191–195
(08 January 2009); doi:10.1038/nature07591
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letter
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
Nature 457, 200–204
(08 January 2009); doi:10.1038/nature07475
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article
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
Tom Cupedo et al.
Nature Immunology 10, 66–74
(January 2009); doi:10.1038/ni.1668
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article
Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin
Carmelo Luci et al.
Nature Immunology 10, 75–82
(January 2009); doi:10.1038/ni.1681
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article
RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
Stephanie L Sanos et al.
Nature Immunology 10, 83–91
(January 2009); doi:10.1038/ni.1684
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news and views
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Karl-Johan Malmberg & Hans-Gustaf Ljunggren
Nature Immunology 10, 11–12
(January 2009); doi:10.1038/ni0109-11
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review
SLAM receptors and SAP influence lymphocyte interactions, development and function
Pamela L. Schwartzberg, Kristen L. Mueller, Hai Qi & Jennifer L. Cannons
Nature Reviews Immunology 9, 39–46
(January 2009); doi:10.1038/nri2456
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