Research library: Ion channels
2004:December
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December
article
The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation
Laura Bianchi, Beate Gerstbrein, Christian Frøkjær-Jensen, Dewey C Royal, Gargi Mukherjee, Mary Anne Royal, Jian Xue, William R Schafer and Monica Driscoll
Nature Neuroscience 7, 1337–1344
(December 2004); doi:10.1038/nn1347
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article
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
David P. Corey , Jaime García-Añoveros, Jeffrey R. Holt, Kelvin Y. Kwan , Shuh-Yow Lin , Melissa A. Vollrath , Andrea Amalfitano, Eunice L.-M. Cheung, Bruce H. Derfler, Anne Duggan, Gwénaëlle S. G. Géléoc, Paul A. Gray, Matthew P. Hoffman, Heidi L. Rehm, Daniel Tamasauskas and Duan-Sun Zhang
Nature 432, 723–730
(09 December 2004); doi:10.1038/nature03066
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news and views
Hearing: Channel at the hair's end
Jonathan Ashmore
Nature 432, 685–686
(09 December 2004); doi:10.1038/432685a
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article
A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals
Hiroshi Nishimune, Joshua R. Sanes and Steven S. Carlson
Nature 432, 580–587
(02 December 2004); doi:10.1038/nature03112
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technical review
Light-activated ion channels for remote control of neuronal firing
Matthew Banghart, Katharine Borges, Ehud Isacoff, Dirk Trauner and Richard H Kramer
Nature Neuroscience 7, 1381–1386
(December 2004); doi:10.1038/nn1356
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news and views
A molecular light switch turns off neural activity
Cara Allen
Nature Neuroscience 7, 1291
(December 2004); doi:10.1038/nn1204-1291
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November
news and views
Transporter of a malaria catastrophe
Thomas E Wellems
Nature Medicine 10, 1169–1171
(November 2004); doi:10.1038/nm1104-1169
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news and views
Structural biology: Ion pump in the movies
C. Roy D. Lancaster
Nature 432, 286–287
(18 November 2004); doi:10.1038/432286a
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article
Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle
Takahiro Iwamoto, Satomi Kita, Jin Zhang, Mordecai P Blaustein, Yuji Arai, Shigeru Yoshida, Koji Wakimoto, Issei Komuro and Takeshi Katsuragi
Nature Medicine 10, 1193–1199
(November 2004); doi:10.1038/nm1118
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news and views
Hypertension with a grain of salt
Ursula Danilczyk and Josef Penninger
Nature Medicine 10, 1163–1164
(November 2004); doi:10.1038/nm1104-1163
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October
review article
Ca2+-activated K+ channels: molecular determinants and function of the SK family
Martin Stocker
Nature Reviews Neuroscience 5, 758–770
(October 2004); doi:10.1038/nrn1516
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article
Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function
Françoise Haeseleer, Yoshikazu Imanishi, Tadao Maeda, Daniel E Possin, Akiko Maeda, Amy Lee, Fred Rieke and Krzysztof Palczewski
Nature Neuroscience 7, 1079–1087
(October 2004); doi:10.1038/nn1320
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article
Control of human potassium channel inactivation by editing of a small mRNA hairpin
Tarun Bhalla, Joshua J C Rosenthal, Miguel Holmgren and Robert Reenan
Nature Structural and Molecular Biology 11, 950–956
(October 2004); doi:10.1038/nsmb825
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news and views
RNA editing of a human potassium channel modifies its inactivation
Francisco Bezanilla
Nature Structural and Molecular Biology 11, 915–916
(October 2004); doi:10.1038/nsmb1004-915
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September
letters to nature
Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
Seung K. Kim and Eric J. Rulifson
Nature 431, 316–320
(16 September 2004); doi:10.1038/nature02897
| First Paragraph | Full Text (HTML / PDF) |
August
letters to nature
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
Cecilia Bouzat, Fernanda Gumilar, Guillermo Spitzmaul, Hai-Long Wang, Diego Rayes, Scott B. Hansen, Palmer Taylor and Steven M. Sine
Nature 430, 896–900
(19 August 2004); doi:10.1038/nature02753
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article
Rapid vesicular translocation and insertion of TRP channels
Vassilios J. Bezzerides, I. Scott Ramsey, Suhas Kotecha, Anna Greka and David E. Clapham
Nature Cell Biology 6, 709–720
(August 2004); doi:10.1038/ncb1150
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news and views
Exciting trips for TRPs
Craig Montell
Nature Cell Biology 6, 690–692
(August 2004); doi:10.1038/ncb0804-690
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article
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
Thomas Voets, Guy Droogmans, Ulrich Wissenbach, Annelies Janssens, Veit Flockerzi and Bernd Nilius
Nature 430, 748–754
(12 August 2004); doi:10.1038/nature02732
| Summary | Full Text (HTML / PDF) |
letters to nature
Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation
Qiu-Xing Jiang, Da-Neng Wang and Roderick MacKinnon
Nature 430, 806–810
(12 August 2004); doi:10.1038/nature02735
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July
article
Crystal structure of the calcium pump with a bound ATP analogue
Chikashi Toyoshima and Tatsuaki Mizutani
Nature 430, 529–535
(29 July 2004); doi:10.1038/nature02680
| Abstract | Full Text (HTML / PDF) |
article
Calmodulin permanently associates with rat olfactory CNG channels under native conditions
Jonathan Bradley, Wolfgang Bönigk, King-Wai Yau and Stephan Frings
Nature Neuroscience 7, 705–710
(July 2004); doi:10.1038/nn1266
| Abstract | Full Text (HTML/PDF) |
news and views
Making scents of olfactory adaptation
John P Adelman and Paco S Herson
Nature Neuroscience 7, 689–690
(July 2004); doi:10.1038/nn0704-689
| Full Text (HTML/PDF) |
review article
The neurobiology of antiepileptic drugs
Michael A. Rogawski and Wolfgang Löscher
Nature Reviews Neuroscience 5, 553–564
(July 2004); doi:10.1038/nrn1430
| Abstract | Full Text (HTML / PDF) |
letters to nature
A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom
Seok-Yong Lee and Roderick MacKinnon
Nature 430, 232–235
(08 July 2004); doi:10.1038/nature02632
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letters to nature
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers
Thomas M. Suchyna, Sonya E. Tape, Roger E. Koeppe II, Olaf S. Andersen, Frederick Sachs and Philip A. Gottlieb
Nature 430, 235–240
(08 July 2004); doi:10.1038/nature02743
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news and views
Ion channels: Gate expectations
Maria L. Garcia
Nature 430, 153–155
(08 July 2004); doi:10.1038/430153a
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article
Regulation of ion channel localization and phosphorylation by neuronal activity
Hiroaki Misonou, Durga P Mohapatra, Eunice W Park, Victor Leung, Dongkai Zhen, Kaori Misonou, Anne E Anderson and James S Trimmer
Nature Neuroscience 7, 711–718
(July 2004); doi:10.1038/nn1260
| Abstract | Full Text (HTML/PDF) |
news and views
A mechanism for homeostatic plasticity
D James Surmeier and Robert Foehring
Nature Neuroscience 7, 691–692
(July 2004); doi:10.1038/nn0704-691
| Full Text (HTML/PDF) |
June
news and views
Opening the gate in potassium channels
Kenton J Swartz
Nature Structural and Molecular Biology 11, 499–501
(June 2004); doi:10.1038/nsmb0604-499
| Full Text (HTML/PDF) |
letters to nature
Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain
Filip Van Petegem, Kimberly A. Clark, Franck C. Chatelain and Daniel L. Minor Jr
Nature 429, 671–675
(10 June 2004); doi:10.1038/nature02588
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letters to nature
Structural basis of the α1-β subunit interaction of voltage-gated Ca2+ channels
Yu-hang Chen, Ming-hui Li, Yun Zhang, Lin-ling He, Yoichi Yamada, Aileen Fitzmaurice, Yang Shen, Hailong Zhang, Liang Tong and Jian Yang
Nature 429, 675–680
(10 June 2004); doi:10.1038/nature02641
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May
review article
Genetic mechanisms that underlie epilepsy
Ortrud K. Steinlein
Nature Reviews Neuroscience 5, 400–408
(May 2004); doi:10.1038/nrn1388
| Abstract | Full Text (HTML / PDF) |
letter
Functional variants of OCTN cation transporter genes are associated with Crohn disease
Vanya D Peltekova, Richard F Wintle, Laurence A Rubin, Christopher I Amos, Qiqing Huang, Xiangjun Gu, Bill Newman, Mark Van Oene, David Cescon, Gordon Greenberg, Anne M Griffiths, Peter H St George-Hyslop and Katherine A Siminovitch
Nature Genetics 36, 471–475
(May 2004); doi:10.1038/ng1339
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article
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
Marcus Mall, Barbara R Grubb, Jack R Harkema, Wanda K O'Neal and Richard C Boucher
Nature Medicine 10, 487–493
(May 2004); doi:10.1038/nm1028
| Abstract | Full Text (HTML/PDF) |
news and views
Finally, mice with CF lung disease
Raymond A Frizzell and Joseph M Pilewski
Nature Medicine 10, 452–454
(May 2004); doi:10.1038/nm0504-452
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April
letters to nature
Cadherin 23 is a component of the tip link in hair-cell stereocilia
Jan Siemens, Concepcion Lillo, Rachel A. Dumont, Anna Reynolds, David S. Williams, Peter G. Gillespie and Ulrich Müller
Nature 428, 950–955
(29 April 2004); doi:10.1038/nature02483
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letters to nature
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells
Christian Söllner, Gerd-Jörg Rauch, Jan Siemens, Robert Geisler, Stephan C. Schuster, the Tübingen 2000 Screen Consortium, Ulrich Müller and Teresa Nicolson
Nature 428, 955–959
(29 April 2004); doi:10.1038/nature02484
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news and views
Hearing: Tightrope act
David P. Corey and Marcos Sotomayor
Nature 428, 901–903
(29 April 2004); doi:10.1038/428901a
| Full Text (HTML / PDF) |
letter
Gating of CFTR by the STAS domain of SLC26 transporters
Shigeru B.H. Ko, Weizhong Zeng, Michael R. Dorwart, Xiang Luo, Kil Hwan Kim, Linda Millen, Hidemi Goto, Satoru Naruse, Abigail Soyombo, Philip J. Thomas and Shmuel Muallem
Nature Cell Biology 6, 343–350
(April 2004); doi:10.1038/ncb1115
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news and views
Bicarbonate secretion: it takes two to tango
Michael A. Gray
Nature Cell Biology 6, 292–294
(April 2004); doi:10.1038/ncb0404-292
| Full Text (HTML/PDF) |
letters to nature
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
Sarah M. Webster, Donato del Camino, John P. Dekker and Gary Yellen
Nature 428, 864–868
(22 April 2004); doi:10.1038/nature02468
| First Paragraph | Full Text (HTML / PDF) |
review article
Biology, structure and mechanism of P-type ATPases
Werner Kühlbrandt
Nature Reviews Molecular Cell Biology 5, 282–295
(April 2004); doi:10.1038/nrm1354
| Abstract | Full Text (HTML / PDF) |
letter
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
Martin Bienengraeber, Timothy M Olson, Vitaliy A Selivanov, Eva C Kathmann, Fearghas O'Cochlain, Fan Gao, Amy B Karger, Jeffrey D Ballew, Denice M Hodgson, Leonid V Zingman, Yuan-Ping Pang, Alexey E Alekseev and Andre Terzic
Nature Genetics 36, 382–387
(April 2004); doi:10.1038/ng1329
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March
twenty questions
The state of ion channel research in 2004
The Nature Reviews Drug Discovery Ion Channel Questionnaire Participants
Nature Reviews Drug Discovery 3, 239–278
(March 2004); doi:10.1038/nrd1361
| Abstract | Full Text (HTML / PDF) |
article
An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability
Tammy L Wingo, Vikas N Shah, Mark E Anderson, Terry P Lybrand, Walter J Chazin and Jeffrey R Balser
Nature Structural and Molecular Biology 11, 219–225
(March 2004); doi:10.1038/nsmb737
| Abstract | Full Text (HTML/PDF) |
February
article
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels
Alessio Accardi and Christopher Miller
Nature 427, 803–807
(26 February 2004); doi:10.1038/nature02314
| Abstract | Full Text (HTML / PDF) |
news and views
Ion transport: Spot the difference
David C. Gadsby
Nature 427, 795–797
(26 February 2004); doi:10.1038/427795a
| Full Text (HTML / PDF) |
letters to nature
The large-conductance Ca2+-activated K+ channel is essential for innate immunity
Jatinder Ahluwalia, Andrew Tinker, Lucie H. Clapp, Michael R. Duchen, Andrey Y. Abramov, Simon Pope, Muriel Nobles and Anthony W. Segal
Nature 427, 853–858
(26 February 2004); doi:10.1038/nature02356
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article
Agonist-independent modulation of N-type calcium channels by ORL1 receptors
Aaron M Beedle, John E McRory, Olivier Poirot, Clinton J Doering, Christophe Altier, Christian Barrere, Jawed Hamid, Joel Nargeot, Emmanuel Bourinet and Gerald W Zamponi
Nature Neuroscience 7, 118–125
(February 2004); doi:10.1038/nn1180
| Abstract | Full Text (HTML/PDF) |
article
Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system
Hans G Cruz, Tatiana Ivanova, Marie-Louise Lunn, Markus Stoffel, Paul A Slesinger and Christian Lüscher
Nature Neuroscience 7, 153–159
(February 2004); doi:10.1038/nn1181
| Abstract | Full Text (HTML/PDF) |
letters to nature
A proton pore in a potassium channel voltage sensor reveals a focused electric field
Dorine M. Starace and Francisco Bezanilla
Nature 427, 548–553
(05 February 2004); doi:10.1038/nature02270
| First Paragraph | Full Text (HTML / PDF) |
news and views
Ion channels: Shake, rattle or roll?
Robert O. Blaustein and Christopher Miller
Nature 427, 553–558
(05 February 2004); doi:10.1038/nature02288
| Full Text (HTML / PDF) |
letter
A novel mechanism for the store-operated calcium influx pathway
Tarik Smani, Sergey I. Zakharov, Peter Csutora, Endri Leno, Elena S. Trepakova and Victoria M. Bolotina
Nature Cell Biology 6, 113–120
(February 2004); doi:10.1038/ncb1089
| First Paragraph | Full Text (HTML/PDF) |
letter
FRET between cardiac Na+ channel subunits measured with a confocal microscope and a streak camera
Christoph Biskup, Thomas Zimmer and Klaus Benndorf
Nature Biotechnology 22, 220–224
(February 2004) ; doi:10.1038/nbt935
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article
Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing
Xiang Dong Tang, Maria L Garcia, Stefan H Heinemann and Toshinori Hoshi
Nature Structural and Molecular Biology 11, 171–178
(February 2004); doi:10.1038/nsmb725
| Abstract | Full Text (HTML/PDF) |
January
letters to nature
The mitochondrial calcium uniporter is a highly selective ion channel
Yuriy Kirichok, Grigory Krapivinsky and David E. Clapham
Nature 427, 360–364
(22 January 2004); doi:10.1038/nature02246
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letters to nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Sven-Eric Jordt, Diana M. Bautista, Huai-hu Chuang, David D. McKemy, Peter M. Zygmunt, Edward D. Högestätt, Ian D. Meng and David Julius
Nature 427, 260–265
(15 January 2004); doi:10.1038/nature02282
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article
X-ray structure of a protein-conducting channel
Bert van den Berg, William M. Clemons Jr, Ian Collinson, Yorgo Modis, Enno Hartmann, Stephen C. Harrison and Tom A. Rapoport
Nature 427, 36–44
(01 January 2004); doi:10.1038/nature02218
| Abstract | Full Text (HTML / PDF) |
news and views
Cell biology: Shape-shifting protein channel
Jordi Benach and John F. Hunt
Nature 427, 24–26
(01 January 2004); doi:10.1038/427024a
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