Research library: Kinases
2002: December | November
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December
letters to nature
A role for casein kinase 2α in the Drosophila circadian clock
Jui-Ming Lin, Valerie L. Kilman, Kevin Keegan, Brie Paddock, Myai Emery-Le, Michael Rosbash and Ravi Allada
Nature 420, 816–820
(19 December 2002); doi:10.1038/nature01235
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brief communication
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J. Romanienko, Julio C. Morales, Kazuhito Naka, Zhenfang Xia, R. Daniel Camerini-Otero, Noboru Motoyama, Phillip B. Carpenter, William M. Bonner, Junjie Chen and André Nussenzweig
Nature Cell Biology 4, 993–997
(December 2002); doi:10.1038/ncb884
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brief communication
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
Richard A. DiTullio, Jr Tamara A. Mochan, Monica Venere, Jirina Bartkova, Maxwell Sehested, Jiri Bartek and Thanos D. Halazonetis
Nature Cell Biology 4, 998–1002
(December 2002); doi:10.1038/ncb892
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news and views
Checkpoint signalling: focusing on 53BP1
Robert T. Abraham
Nature Cell Biology 4, E277
(December 2002); doi:10.1038/ncb1202-e277
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letter
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Robert J. Mallis, Kristine N. Brazin, D. Bruce Fulton and Amy H. Andreotti
Nature Structural Biology 9, 900–905
(December 2002); doi:10.1038/nsb864
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letters to nature
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
Hyuk Wan Ko, Jin Jiang and Isaac Edery
Nature AOP published online 20 November 2002; doi:10.1038/nature01272
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letters to nature
Signal-dependent regulation of splicing via phosphorylation of Sam68
Nathalie Matter, Peter Herrlich and Harald König
Nature 420, 691–695
(12 December 2002); doi:10.1038/nature01153
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article
ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly
Felipe Palacios, Jill K. Schweitzer, Rita L. Boshans and Crislyn D'Souza-Schorey
Nature Cell Biology 4, 929–936
(December 2002); doi:10.1038/ncb881
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brief communication
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
Hector Valderrama-Carvajal, Eftihia Cocolakis, Annie Lacerte, Eun-Hye Lee, Gerald Krystal, Suhad Ali and Jean-Jacques Lebrun
Nature Cell Biology 4, 963–969
(December 2002); doi:10.1038/ncb885
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review article
Regulation of B-cell fate by antigen-receptor signals
Hiroaki Niiro and Edward A. Clark
Nature Reviews Immunology 2, 945–956
(December 2002); doi:10.1038/nri955
| Summary | Full Text (HTML / PDF) |
letter
Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP
Jing Yang, Peter Cron, Valerie M. Good, Vivienne Thompson, Brian A. Hemmings and David Barford
Nature Structural Biology 9, 940–944
(December 2002); doi:10.1038/nsb870
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brief communication
Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis
Antonio Baonza, Christopher M. Murawsky, Andrew A. Travers and Matthew Freeman
Nature Cell Biology 4, 976–980
(December 2002); doi:10.1038/ncb887
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perspectives
Timeline: Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Stephen M. Dilworth
Nature Reviews Cancer 2, 951–956
(December 2002); doi:10.1038/nrc946
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brief communication
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
Emanuela Izzo, Rémi Martin-Fardon, George F. Koob, Friedbert Weiss and Pietro Paolo Sanna
Nature Neuroscience 5, 1263–1264
(December 2002); doi:10.1038/nn977
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November
letters to nature
Functional improvement of dystrophic muscle by myostatin blockade
Sasha Bogdanovich, Thomas O. B. Krag, Elisabeth R. Barton, Linda D. Morris, Lisa-Anne Whittemore, Rexford S. Ahima and Tejvir S. Khurana
Nature 420, 418–421
(28 November 2002); doi:10.1038/nature01154
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letters to nature
Shoot control of root development and nodulation is mediated by a receptor-like kinase
Lene Krusell, Lene H. Madsen, Shusei Sato, Grégoire Aubert, Aratz Genua, Krzysztof Szczyglowski, Gérard Duc, Takakazu Kaneko, Satoshi Tabata, Frans de Bruijn, Eloisa Pajuelo, Niels Sandal and Jens Stougaard
Nature 420, 422–426
(28 November 2002); doi:10.1038/nature01207
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letters to nature
HAR1 mediates systemic regulation of symbiotic organ development
Rieko Nishimura , Masaki Hayashi, Guo-Jiang Wu , Hiroshi Kouchi, Haruko Imaizumi-Anraku, Yasuhiro Murakami, Shinji Kawasaki, Shoichiro Akao, Masayuki Ohmori, Mamoru Nagasawa, Kyuya Harada and Masayoshi Kawaguchi
Nature 420, 426–429
(28 November 2002); doi:10.1038/nature01231
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news and views
Plant biology: Fixation with regulation
J. Allan Downie and Martin Parniske
Nature 420, 369–370
(28 November 2002); doi:10.1038/420369a
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letters to nature
A central role for JNK in obesity and insulin resistance
Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z. Görgün, K. Teoman Uysal, Kazuhisa Maeda, Michael Karin and Gökhan S. Hotamisligil
Nature 420, 333–336
(21 November 2002); doi:10.1038/nature01137
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review article
Evasion of innate immunity by parasitic protozoa
David Sacks and Alan Sher
Nature Immunology 3, 1041–1047
(November 2002); doi:10.1038/ni1102-1041
| Abstract | Full Text (HTML/PDF) |
brief communication
Hippocampal CRE-mediated gene expression is required for contextual memory formation
Jaime Athos, Soren Impey, Victor V. Pineda, Xi Chen and Daniel R. Storm
Nature Neuroscience 5, 1119–1120
(November 2002); doi:10.1038/nn951
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review article
Ubiquitin and the synapse
Ashok N. Hegde and Aaron DiAntonio
Nature Reviews Neuroscience 3, 854–861
(November 2002); doi:10.1038/nrn961
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article
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga and Eisuke Nishida
Nature Cell Biology 4, 850–858
(November 2002); doi:10.1038/ncb867
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article
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
Shutong Yang, Christin Kuo, John E. Bisi and Myung K. Kim
Nature Cell Biology 4, 865–870
(November 2002); doi:10.1038/ncb869
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news and views
Chk2 leaves the PML depot
Monica Venere, Tamara A. Mochan and Thanos D. Halazonetis
Nature Cell Biology 4, E255
(November 2002); doi:10.1038/ncb1102-e255
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article
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis
Richard Sharp, Juan A. Recio, Chamelli Jhappan, Toshiyuki Otsuka, Shiquan Liu, Yanlin Yu, Wenjing Liu, Miriam Anver, Fariba Navid, Lee J. Helman, Ronald A. DePinho and Glenn Merlino
Nature Medicine 8, 1276–1280
(November 2002); doi:10.1038/nm787
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news and views
Muscling in on rhabdomyosarcoma
Webster K. Cavenee
Nature Medicine 8, 1200–1201
(November 2002); doi:10.1038/nm1102-1200
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article
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, S. Uchida, S. Yamashita, M. Noda, S. Kita, K. Ueki, K. Eto, Y. Akanuma, P. Froguel, F. Foufelle, P. Ferre, D. Carling, S. Kimura, R. Nagai, B.B. Kahn and T. Kadowaki
Nature Medicine 8, 1288–1295
(November 2002); doi:10.1038/nm788
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review article
The molecular organization of cerebellar long-term depression
Masao Ito
Nature Reviews Neuroscience 3, 896–902
(November 2002); doi:10.1038/nrn962
| Summary | Full Text (HTML / PDF) |
original paper
Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases
Akhilesh Pandey, Blagoy Blagoev, Irina Kratchmarova, Minerva Fernandez, Mogens Nielsen, Troels Zakarias Kristiansen, Osamu Ohara, Alexandre V Podtelejnikov, Serge Roche, Harvey F Lodish & Matthias Mann
Oncogene 21, 8029–8036
(14 November 2002); doi:10.1038/sj.onc.1205988
| Abstract |
article
Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
Patrick S. Costello, Maighread Gallagher and Doreen A. Cantrell
Nature Immunology 3, 1082–1089
(November 2002); doi:10.1038/ni848
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article
Imaging antigen-induced PI3K activation in T cells
Julie Harriague and Georges Bismuth
Nature Immunology 3, 1090–1096
(November 2002); doi:10.1038/ni847
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news and views
Slick signaling
Andrey S.-Y. Shaw
Nature Immunology 3, 1058–1059
(November 2002); doi:10.1038/ni1102-1058
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article
Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy
Motoaki Sano, Maha Abdellatif, Hidemasa Oh, Min Xie, Luigi Bagella, Antonio Giordano, Lloyd H. Michael, Francesco J. DeMayo and Michael D. Schneider
Nature Medicine 8, 1310–1317
(November 2002); doi:10.1038/nm778
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letters to nature
Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2
Li Wu, Claudia S. Bauer, Xiao-guang Zhen, Cheng Xie and Jian Yang
Nature 419, 947–952
(31 October 2002); doi:10.1038/nature01118
| First Paragraph | Full Text (HTML / PDF) |
brief communication
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
Jorrit M. Enserink, Anne E. Christensen, Johan de Rooij, Miranda van Triest, Frank Schwede, Hans Gottfried Genieser, Stein O. Døskeland, Jonathan L. Blank and Johannes L. Bos
Nature Cell Biology 4, 901–906
(November 2002); doi:10.1038/ncb874
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original paper
Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines
Giulia De Falco, Luca Maria Neri, Maria De Falco, Cristiana Bellan, Zailin Yu, Antonio De Luca, Lorenzo Leoncini and Antonio Giordano
Oncogene 21, 7464–7470
(24 October 2002); doi:10.1038/sj.onc.1205967
| Full Text (HTML/PDF) |
October
letters to nature
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
Hongwu Zheng, Han You, Xiao Zhen Zhou, Stephen A. Murray, Takafumi Uchida, Gerburg Wulf, Ling Gu, Xiaoren Tang, Kun Ping Lu and Zhi-Xiong Jim Xiao
Nature 419, 849–853
(24 October 2002); doi:10.1038/nature01116
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letters to nature
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
Paola Zacchi , Monica Gostissa, Takafumi Uchida, Clio Salvagno, Fabio Avolio, Stefano Volinia, Ze'ev Ronai, Giovanni Blandino, Claudio Schneider and Giannino Del Sal
Nature 419, 853–857
(24 October 2002); doi:10.1038/nature01120
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news and views
Cancer: Pinning a change on p53
Kevin M. Ryan and Karen H. Vousden An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.
Nature 419, 795–797
(24 October 2002); doi:10.1038/419795a
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article
Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes
Mei Huang, Feng Qian, Yuanyu Hu, Chengeng Ang, Zhong Li and Zilong Wen
Nature Cell Biology 4, 774–781
(October 2002); doi:10.1038/ncb855
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article
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Robert Blum, Karl W. Kafitz and Arthur Konnerth
Nature 419, 687–693
(17 October 2002); doi:10.1038/nature01085
| Summary | Full Text (HTML / PDF) |
news and views
Neurobiology: Neurotrophin channels excitement
Yves-Alain Barde
Nature 419, 683–684
(17 October 2002); doi:10.1038/419683a
| Full Text (HTML / PDF) |
letters to nature
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
Joan Seoane, Hong-Van Le and Joan Massagué
Nature 419, 729–734
(17 October 2002); doi:10.1038/nature01119
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article
Staging and resetting T cell activation in SMACs
Benjamin A. Freiberg, Hannah Kupfer, William Maslanik, Joe Delli, John Kappler, Dennis M. Zaller and Abraham Kupfer
Nature Immunology 3, 911–917
(October 2002); doi:10.1038/ni836
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article
Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
Dorian B. McGavern, Urs Christen and Michael B.A. Oldstone
Nature Immunology 3, 918–925
(October 2002); doi:10.1038/ni843
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article
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Estefania Claudio, Keith Brown, Sun Park, Hongshan Wang and Ulrich Siebenlist
Nature Immunology 3, 958–965
(October 2002); doi:10.1038/ni842
| Abstract | Full Text (HTML/PDF) |
news and views
Gatekeeper mechanisms for immature B cells
Xiao-Hong Sun and Paul W. Kincade
Nature Immunology 3, 898–899
(October 2002); doi:10.1038/ni1002-898
| Full Text (HTML/PDF) |
news and views
Quorum sensing in Vibrio cholerae
Miguel Cámara, Andrea Hardman, Paul Williams and Debra Milton
Nature Genetics 32, 217–218
(October 2002); doi:10.1038/ng1002-217
| Full Text (HTML/PDF) |
article
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
Giuseppe Viglietto, Maria Letizia Motti, Paola Bruni, Rosa Marina Melillo, Amelia D'Alessio, Daniela Califano, Floriana Vinci, Gennaro Chiappetta, Philip Tsichlis, Alfonso Bellacosa, Alfredo Fusco and Massimo Santoro
Nature Medicine 8, 1136–1144
(October 2002); doi:10.1038/nm762
| Abstract | Full Text (HTML/PDF) |
article
PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization
Incheol Shin, F Michael Yakes, Federico Rojo, Nah-Young Shin, Andrei V. Bakin, Jose Baselga and Carlos L. Arteaga
Nature Medicine 8, 1145–1152
(October 2002); doi:10.1038/nm759
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article
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
Jiyong Liang, Judit Zubovitz, Teresa Petrocelli, Rouslan Kotchetkov, Michael K. Connor, Kathy Han, Jin-Hwa Lee, Sandra Ciarallo, Charles Catzavelos, Richard Beniston, Edmee Franssen and Joyce M. Slingerland
Nature Medicine 8, 1153–1160
(October 2002); doi:10.1038/nm761
| Abstract | Full Text (HTML/PDF) |
news and views
Breast cancer banishes p27 from nucleus
Stacy W. Blain and Joan Massagué
Nature Medicine 8, 1076–1078
(October 2002); doi:10.1038/nm1002-1076
| Full Text (HTML/PDF) |
letter
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization
Genie C. Leung, John W. Hudson, Anna Kozarova, Alan Davidson, James W. Dennis and Frank Sicheri
Nature Structural Biology 9, 719–724
(October 2002); doi:10.1038/nsb848
| First Paragraph | Full Text (HTML/PDF) |
article
Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
Dorian B. McGavern, Urs Christen and Michael B.A. Oldstone
Nature Immunology 3, 918–925
(October 2002); doi:10.1038/ni843
| First Paragraph | Full Text (HTML/PDF) |
letter
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
Johane Robitaille, Marcia L.E. MacDonald, Ajamete Kaykas, Laird C. Sheldahl, Jutta Zeisler, Marie-Pierre Dubé, Lin-Hua Zhang, Roshni R. Singaraja, Duane L. Guernsey, Binyou Zheng, Lee F. Siebert, Ann Hoskin-Mott, Michael T. Trese, Simon N. Pimstone, Barkur S. Shastry, Randall T. Moon, Michael R. Hayden, Y. Paul Goldberg and Mark E. Samuels
Nature Genetics 32, 326–330
(October 2002); doi:10.1038/ng957
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letter
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
Thomas G. Davies, Johanne Bentley, Christine E. Arris, F. Thomas Boyle, Nicola J. Curtin, Jane A. Endicott, Ashleigh E. Gibson, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Philip Jewsbury, Louise N. Johnson, Veronique Mesguiche, David R. Newell, Martin E.M. Noble, Julie A. Tucker, Lan Wang and Hayley J. Whitfield
Nature Structural Biology 9, 745–749
(October 2002); doi:10.1038/nsb842
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article
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Mirella Lazarov, Yoshiaki Kubo, Ti Cai, Maya Dajee, Masahito Tarutani, Qun Lin, Min Fang, Shiying Tao, Cheryl L. Green and Paul A. Khavari
Nature Medicine 8, 1105–1114
(October 2002); doi:10.1038/nm779
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article
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
Minerva M. Carrasquillo, Andrew S. McCallion, Erik G. Puffenberger, Carl S. Kashuk, Nassim Nouri and Aravinda Chakravarti
Nature Genetics 32, 237–244
(October 2002); doi:10.1038/ng998
| Abstract | Full Text (HTML/PDF) |
September
article
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
Ratna K. Vadlamudi, Feng Li, Liana Adam, Diep Nguyen, Yasutaka Ohta, Thomas P. Stossel and Rakesh Kumar
Nature Cell Biology 4, 681–690
(September 2002); doi:10.1038/ncb838
| Abstract | Full Text (HTML/PDF) |
perspectives
Timeline: Cyclic nucleotide research — still expanding after half a century
Joseph A. Beavo and Laurence L. Brunton
Nature Reviews Molecular Cell Biology 3, 710–718
(September 2002); doi:10.1038/nrm911
| Summary | Full Text (HTML / PDF) |
letter
Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts
Patricia Hess, German Pihan, Charles L. Sawyers, Richard A. Flavell and Roger J. Davis
Nature Genetics 32, 201–205
(September 2002); doi:10.1038/ng946
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brief communication
A-kinase anchoring proteins in amygdala are involved in auditory fear memory
Marta A.P. Moita, Raphael Lamprecht, Karim Nader and Joseph E. LeDoux
Nature Neuroscience 5, 837–838
(September 2002); doi:10.1038/nn901
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letters to nature
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Geert J. P. L. Kops, Tobias B. Dansen, Paulien E. Polderman, Ingrid Saarloos, Karel W. A. Wirtz, Paul J. Coffer, Ting-T. Huang, Johannes L. Bos, René H. Medema and Boudewijn M. T. Burgering
Nature 419, 316–321
(19 September 2002); doi:10.1038/nature01036
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article
Sensitization of IFN-g Jak-STAT signaling during macrophage activation
Xiaoyu Hu, Carmen Herrero, Wai-Ping Li, Taras T. Antoniv, Erik Falck-Pedersen, Alisa E. Koch, James M. Woods, G. Kenneth Haines and III Lionel B. Ivashkiv
Nature Immunology 3, 859–866
(September 2002); doi:10.1038/ni828
| Abstract | Full Text (HTML/PDF) |
letters to nature
Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
Valery N. Bochkov, Alexandra Kadl, Joakim Huber, Florian Gruber, Bernd R. Binder and Norbert Leitinger
Nature 419, 77–81
(05 September 2002); doi:10.1038/nature01023
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article
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu and Kun-Liang Guan
Nature Cell Biology 4, 648–657
(September 2002); doi:10.1038/ncb839
| Abstract | Full Text (HTML/PDF) |
article
Akt regulates growth by directly phosphorylating Tsc2
Christopher J. Potter, Laura G. Pedraza and Tian Xu
Nature Cell Biology 4, 658–665
(September 2002); doi:10.1038/ncb840
| Abstract | Full Text (HTML/PDF) |
brief communication
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
Xinsheng Gao, Yong Zhang, Peter Arrazola, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Binggeng Ru and Duojia Pan
Nature Cell Biology 4, 699–704
(September 2002); doi:10.1038/ncb847
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news and views
TSC1-TSC2: a complex tale of PKB-mediated S6K regulation
Edward J. McManus and Dario R. Alessi
Nature Cell Biology 4, E214
(September 2002); doi:10.1038/ncb0902-e214
| Full Text (HTML/PDF) |
brief communication
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila
Erina Kuranaga, Hirotaka Kanuka, Tatsushi Igaki, Kazunobu Sawamoto, Hidenori Ichijo, Hideyuki Okano and Masayuki Miura
Nature Cell Biology 4, 705–710
(September 2002); doi:10.1038/ncb842
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letter
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice
Anders H. Lund, Geoffrey Turner, Alla Trubetskoy, Els Verhoeven, Ellen Wientjens, Danielle Hulsman, Robert Russell, Ronald A. DePinho, Jack Lenz and Maarten van Lohuizen
Nature Genetics 32, 160–165
(September 2002); doi:10.1038/ng956
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article
A requirement for CARMA1 in TCR-induced NF-kB activation
Donghai Wang, Yun You, Sara M. Case, Linda M. McAllister-Lucas, Lin Wang, Peter S. DiStefano, Gabriel Nuñez, John Bertin and Xin Lin
Nature Immunology 3, 830–835
(September 2002); doi:10.1038/ni824
| Abstract | Full Text (HTML/PDF) |
article
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kB activation
Olivier Gaide, Benoît Favier, Daniel F. Legler, David Bonnet, Brian Brissoni, Salvatore Valitutti, Claude Bron, Jürg Tschopp and Margot Thome
Nature Immunology 3, 836–843
(September 2002); doi:10.1038/ni830
| Abstract | Full Text (HTML/PDF) |
news and views
Up the down staircase
David Wallach
Nature Immunology 3, 802–803
(September 2002); doi:10.1038/ni0902-802
| Full Text (HTML/PDF) |
review article
Nf-kb, chemokine gene transcription and tumour growth
Ann Richmond
Nature Reviews Immunology 2, 664–674
(September 2002); doi:10.1038/nri887
| Abstract | Full Text (HTML/PDF) |
article
PI3K-mediated negative feedback regulation of IL-12 production in DCs
Taro Fukao, Masanobu Tanabe, Yasuo Terauchi, Takayuki Ota, Satoshi Matsuda, Tomoichiro Asano, Takashi Kadowaki, Tsutomu Takeuchi and Shigeo Koyasu
Nature Immunology 3, 875–881
(September 2002); doi:10.1038/ni825
| Abstract | Full Text (HTML/PDF) |
review article
Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways
Kathleen A. Gallo and Gary L. Johnson
Nature Reviews Molecular Cell Biology 3, 663–672
(September 2002); doi:10.1038/nrm906
| Abstract | Full Text (HTML/PDF) |
review article
Viruses and interferon: A fight for supremacy
Michael G. Katze, Yupeng He and Michael Gale Jr
Nature Reviews Immunology 2, 675–687
(September 2002); doi:10.1038/nri888
| Summary | Full Text (HTML / PDF) |
article
Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor
Manjiri M. Bakre, Yuhong Zhu, Hong Yin, Doug W. Burton, Robert Terkeltaub, Leonard J. Deftos and Judith A. Varner
Nature Medicine 8, 995–1003
(September 2002); doi:10.1038/nm753
| Abstract | Full Text (HTML/PDF) |
brief communication
Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
Michael I. Daw, Zuner A. Bortolotto, Emilia Saulle, Shahid Zaman, Graham L. Collingridge and John T.R. Isaac
Nature Neuroscience 5, 835–836
(September 2002); doi:10.1038/nn903
| First Paragraph | Full Text (HTML/PDF) |
research article
Inhibition of glioma growth by tumor-specific activation of double-stranded RNA-dependent protein kinase PKR
Alexei Shir and Alexander Levitzki
Nature Biotechnology 20, 895–900
(September 2002); doi:10.1038/nbt730
| Abstract | Full Text (HTML/PDF) |
August
brief communication
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
John M. Lambert, Que T. Lambert, Gary W. Reuther, Angeliki Malliri, David P. Siderovski, John Sondek, John G. Collard and Channing J. Der
Nature Cell Biology 4, 621–625
(August 2002); doi:10.1038/ncb833
| First Paragraph | Full Text (HTML/PDF) |
news and views
'ER we go
Rachel Smallridge
Nature Cell Biology 4, E193
(August 2002); doi:10.1038/ncb0802-e193
| Full Text (HTML/PDF) |
review article
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo
Andrea L. Bauman and John D. Scott
Nature Cell Biology 4, E203
(August 2002); doi:10.1038/ncb0802-e203
| Abstract | Full Text (HTML/PDF) |
news and views
Immunology: A block at the toll gate
Tak W. Mak and Wen-Chen Yeh
Nature 418, 835–836
(22 August 2002); doi:10.1038/418835a
| Full Text (HTML / PDF) |
brief communication
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
Egle Avizienyte, Anne W. Wyke, Robert J. Jones, Gordon W. McLean, M. Andrew Westhoff, Valerie G. Brunton and Margaret C. Frame
Nature Cell Biology 4, 632–638
(August 2002); doi:10.1038/ncb829
| First Paragraph | Full Text (HTML/PDF) |
review article
Signal transduction and endocytosis: close encounters of many kinds
Alexander Sorkin and Mark von Zastrow
Nature Reviews Molecular Cell Biology 3, 600–614
(August 2002); doi:10.1038/nrm883
| Summary | Full Text (HTML / PDF) |
letters to nature
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine
Maria Lindskog, Per Svenningsson, Laura Pozzi, Yong Kim, Allen A. Fienberg, James A. Bibb, Bertil B. Fredholm, Angus C. Nairn, Paul Greengard and Gilberto Fisone
Nature 418, 774–778
(15 August 2002); doi:10.1038/nature00817
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news and views
Signal transduction: Positive feedback from coffee
Jean-Marie Vaugeois
Nature 418, 734–736
(15 August 2002); doi:10.1038/418734a
| Full Text (HTML / PDF) |
letters to nature
Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase
Jiaxu Li, Toshinori Kinoshita, Sona Pandey, Carl K.-Y. Ng, Steven P. Gygi, Ken-ichiro Shimazaki and Sarah M. Assmann
Nature 418, 793–797
(15 August 2002); doi:10.1038/nature00936
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Jiandie Lin, Hai Wu, Paul T. Tarr, Chen-Yu Zhang, Zhidan Wu, Olivier Boss, Laura F. Michael, Pere Puigserver, Eiji Isotani, Eric N. Olson, Bradford B. Lowell, Rhonda Bassel-Duby and Bruce M. Spiegelman
Nature 418, 797–801
(15 August 2002); doi:10.1038/nature00904
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news and views
Physiology: Muscle regulator goes the distance
Richard Turner
Nature 418, 740
(15 August 2002); doi:10.1038/418740a
| Full Text (HTML / PDF) |
article
Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
Todd D. Camenisch, Joyce A. Schroeder, Judy Bradley, Scott E. Klewer and John A. McDonald
Nature Medicine 8, 850–855
(August 2002); doi:10.1038/nm742
| Abstract | Full Text (HTML/PDF) |
review article
CDKS and CKIS: Molecular targets for tissue remodelling
Elizabeth G. Nabel
Nature Reviews Drug Discovery 1, 587–598
(August 2002); doi:10.1038/nrd869
| Summary | Full Text (HTML / PDF) |
original paper
Activation of NF-KAPPAB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications
C.S. Mitsiades, N. Mitsiades, V. Poulaki, R. Schlossman, M. Akiyama, D. Chauhan, T. Hideshima, S.P. Treon, N.C. Munshi, P.G. Richardson, K.C. Anderson
Oncogene 21, 5673–5683
(August 2002); doi:10.1038/sj.onc.1205664
| Abstract |
letters to nature
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Petra Pandur, Matthias Läsche, Leonard M. Eisenberg and Michael Kühl
Nature 418, 636–641
(8 August 2002); doi:10.1038/nature00921
| First Paragraph | Full Text (HTML / PDF) |
article
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Aernout Luttun, Marc Tjwa, Lieve Moons, Yan Wu, Anne Angelillo-Scherrer, Fang Liao, Janice A. Nagy, Andrea Hooper, Josef Priller, Bert De Klerck, Veerle Compernolle, Evis Daci, Peter Bohlen, Mieke Dewerchin, Jean-Marc Herbert, Roy Fava, Patrick Matthys, Geert Carmeliet, Désiré Collen, Harold F. Dvorak, Daniel J. Hicklin and Peter Carmeliet
Nature Medicine 8, 831–840
(August 2002); doi:10.1038/nm731
| Abstract | Full Text (HTML/PDF) |
news and views
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies
Ulf Eriksson and Kari Alitalo
Nature Medicine 8, 775–777
(August 2002); doi:10.1038/nm0802-775
| Full Text (HTML/PDF) |
News and Views
MAPping p38 binding interactions
Elizabeth H. Cox
Nature Structural Biology 9, 569
(August 2002); doi:10.1038/nsb0802-569
| Full Text (HTML/PDF) |
Original Paper
Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation
DeChant A.K., Dee K. and Weyman C.M.
Oncogene 21, 5268–5279
(8 August 2002); doi:10.1038/sj.onc.1205648
| Abstract |
letter
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit
Ralph Wäsch and Frederick R. Cross
Nature 418, 556–562
(1 August 2002); doi:10.1038/nature00856
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news and views
Cell cycle: Oscillation sensation
David O. Morgan and James M. Roberts
Nature 418, 495–496
(1 August 2002); doi:10.1038/418495a
| Full Text (HTML/PDF) |
article
Molecular interpretation of ERK signal duration by immediate early gene products
Leon O. Murphy, Sallie Smith, Rey-Huei Chen, Diane C. Fingar and John Blenis
Nature Cell Biology 4, 556–564
(August 2002); doi:10.1038/ncb822
| Abstract | Full Text (HTML/PDF) |
news and views
Common sense signalling
Richard K. Assoian
Nature Cell Biology 4, E187
(August 2002); doi:10.1038/ncb0802-e187
| Full Text (HTML/PDF) |
review article
ERM proteins and merlin: integrators at the cell cortex
Anthony Bretscher, Kevin Edwards and Richard G. Fehon
Nature Reviews Molecular Cell Biology 3, 586–599
(August 2002); doi:10.1038/nrm882
| Abstract | Full Text (HTML/PDF) |
article
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
Valentino Parravicini, Massimo Gadina, Martina Kovarova, Sandra Odom, Claudia Gonzalez-Espinosa, Yasuko Furumoto, Shinichiroh Saitoh, Lawrence E. Samelson, John J. O'Shea and Juan Rivera
Nature Immunology 3, 741–748
(August 2002); doi:10.1038/ni817
| Abstract | Full Text (HTML/PDF) |
news and views
Uncovering new complexities in mast cell signaling
Monica J.S. Nadler and Jean-Pierre Kinet
Nature Immunology 3, 707–708
(August 2002); doi:10.1038/ni0802-707
| Full Text (HTML/PDF) |
article
PKC-β controls IkB kinase lipid raft recruitment and activation in response to BCR signaling
Thomas T. Su, Beichu Guo, Yuko Kawakami, Karen Sommer, Keun Chae, Lisa A. Humphries, Roberta M. Kato, Shin Kang, Lisa Patrone, Randolph Wall, Michael Teitell, Michael Leitges, Toshiaki Kawakami and David J. Rawlings
Nature Immunology 3, 780–786
(August 2002); doi:10.1038/ni823
| Abstract | Full Text (HTML/PDF) |
letter
PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster
Daimark Bennett and Luke Alphey
Nature Genetics 31, 419–423
(August 2002); doi:10.1038/ng938
| First Paragraph | Full Text (HTML/PDF) |
brief communication
A phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
Allan Z. Zhao, Jjing-Ning Huan, Sandhya Gupta, Rekha Pal and Abhiram Sahu
Nature Neuroscience 5, 727–728
(August 2002); doi:10.1038/nn885
| First Paragraph | Full Text (HTML/PDF) |
article
Elevated JNK activation contributes to the pathogenesis of human brain tumors
Oncogene 21, 5038–5046
(August 2002); doi:10.1038/sj.onc.1205593
| Abstract |
July
letter
Placental α2-adrenoceptors control vascular development at the interface between mother and embryo
Melanie Philipp, Marc E. Brede, Kerstin Hadamek, Manfred Gessler, Martin J. Lohse and Lutz Hein
Nature Genetics 31, 311–315
(July 2002); doi:10.1038/ng919
| First Paragraph | Full Text (HTML/PDF) |
review article
LKB1 — A master tumour suppressor of the small intestine and beyond
Lina I. Yoo, Daniel C. Chung and Junying Yuan
Nature Reviews Cancer 2, 529–535
(July 2002); doi:10.1038/nrc843
| Abstract | Full Text (HTML/PDF) |
news and views
TOUCHINGbase: Chemotaxis a la PTEN
Nature Genetics 31, 231
(July 2002); doi:10.1038/ng0702-231
| Full Text (HTML/PDF) |
letter
Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism
Yukio Kato, Saurav Misra, Rosa Puertollano, James H. Hurley and Juan S. Bonifacino
Nature Structural Biology 9, 532–536
(July 2002); doi:10.1038/nsb807
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Distinct roles for cyclins E and A during DNA replication complex assembly and activation
D Coverley, H Laman & R A Laskey
Nature Cell Biology 4, 523–528
(July 2002); doi:10.1038/ncb813
| First Paragraph | Full Text (HTML/PDF) |
brief communication
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
Orion D. Weiner, Paul O. Neilsen, Glenn D. Prestwich, Marc W. Kirschner, Lewis C. Cantley and Henry R. Bourne
Nature Cell Biology 4, 509–513
(July 2002); doi:10.1038/ncb811
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
Fei Wang, Paul Herzmark, Orion D. Weiner, Supriya Srinivasan, Guy Servant and Henry R. Bourne
Nature Cell Biology 4, 513–518
(July 2002); doi:10.1038/ncb810
| First Paragraph | Full Text (HTML/PDF) |
news and views
Leading the way
Ruedi Meili and Richard A. Firtel
Nature Cell Biology 4, E171
(July 2002); doi:10.1038/ncb0702-e171
| Full Text (HTML/PDF) |
article
Myosin X is a downstream effector of PI(3)K during phagocytosis
Dianne Cox, Jonathan S. Berg, Michael Cammer, John O. Chinegwundoh, Benjamin M. Dale, Richard E. Cheney and Steven Greenberg
Nature Cell Biology 4, 469–477
(July 2002); doi:10.1038/ncb805
| Abstract | Full Text (HTML/PDF) |
news and views
May the force be with you: Myosin-X in phagocytosis.
Philippe Chavrier
Nature Cell Biology 4, E169
(July 2002); doi:10.1038/ncb0702-e169
| Full Text (HTML/PDF) |
review article
The phosphatidylinositol 3-Kinase-AKT pathway in human cancer
Igor Vivanco and Charles L. Sawyers
Nature Reviews Cancer 2, 489–501
(July 2002); doi:10.1038/nrc839
| Abstract | Full Text (HTML/PDF) |
review article
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
Renaud Capdeville, Elisabeth Buchdunger, Juerg Zimmermann and Alex Matter
Nature Reviews Drug Discovery 1, 493–502
(July 2002); doi:10.1038/nrd839
| Abstract | Full Text (HTML/PDF) |
June
letter
Mutations of the BRAF gene in human cancer
Helen Davies, Graham R. Bignell, Charles Cox, Philip Stephens et al.
Nature 417, 949–954
(27 June 2002); doi:10.1038/nature00766
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news and views
Cancer: Lucky draw in the gene raffle
Pamela M. Pollock and Paul S. Meltzer
Nature 417, 906–907
(27 June 2002); doi:10.1038/417906a
| Full Text (HTML/PDF) |
letter
A plant receptor-like kinase required for both bacterial and fungal symbiosis
Silke Stracke, Catherine Kistner, Satoko Yoshida, Lonneke Mulder, Shusei Sato, Takakazu Kaneko, Satoshi Tabata, Niels Sandal, Jens Stougaard, Krzysztof Szczyglowski and Martin Parniske
Nature 417, 959–962
(27 June 2002); doi:10.1038/nature00841
| First Paragraph | Full Text (HTML/PDF) |
letter
A receptor kinase gene regulating symbiotic nodule development
Gabriella Endre, Attila Kereszt, Zoltán Kevei, Sorina Mihacea, Péter Kaló and György B. Kiss
Nature 417, 962–966
(27 June 2002); doi:10.1038/nature00842
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news and views
Plant-microbe interactions: A receptor in symbiotic dialogue
Herman P. Spaink
Nature 417, 910–911
(27 June 2002); doi:10.1038/417910a
| Full Text (HTML/PDF) |
review article
T-cell signalling and autoimmunity: molecular mechanisms of disease
Pamela S. Ohashi
Nature Reviews Immunology 2, 427–438
(June 2002); doi:10.1038/nri822
| Abstract | Full Text (HTML/PDF) |
article
Calcium-calmodulin-dependent protein kinase IV is required for fear memory
Feng Wei, Chang-Shen Qiu, Jason Liauw, Daphné A. Robinson, Nga Ho, Talal Chatila and Min Zhuo
Nature Neuroscience 5, 573–579
(June 2002); doi:10.1038/nn855
| Abstract | Full Text (HTML/PDF) |
letter to nature
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
Manolis Pasparakis, Gilles Courtois, Martin Hafner, Marc Schmidt-Supprian, Arianna Nenci, Atiye Toksoy, Monika Krampert, Matthias Goebeler, Reinhard Gillitzer, Alain Israel, Thomas Krieg, Klaus Rajewsky and Ingo Haase
Nature 417, 861–866
(20 June 2002); doi:10.1038/nature00820
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news and views
Cell motility: The attraction of lipids
Amanda Tromans
Nature 417, 702
(20 June 2002); doi:10.1038/417702a
| Full Text (HTML/PDF) |
article
A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility
James W. Legg, Charlotte A. Lewis, Maddy Parsons, Tony Ng and Clare M. Isacke
Nature Cell Biology 4, 399–407
(June 2002); doi:10.1038/ncb797
| Abstract | Full Text (HTML/PDF) |
article
A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor
Bo Yang, John D. Slonimsky and Susan J. Birren
Nature Neuroscience 5, 539–545
(June 2002); doi:10.1038/nn853
| Abstract | Full Text (HTML/PDF) |
news and views
Quick-change artist: from excitatory to inhibitory synapse in minutes
Story C. Landis
Nature Neuroscience 5, 503–504
(June 2002); doi:10.1038/nn0602-503
| Full Text (HTML/PDF) |
letter
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
Dmitry V. Bulavin, Oleg N. Demidov, Shin'ichi Saito, Paivikki Kauraniemi, Crissy Phillips, Sally A. Amundson, Concetta Ambrosino, Guido Sauter, Angel R. Nebreda, Carl W. Anderson, Anne Kallioniemi, Albert J. Fornace Jr & Ettore Appella
Nature Genetics 31, 210–215
(June 2002); doi:10.1038/ng894
| First Paragraph | Full Text (HTML/PDF) |
article
nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
Xiangyun Wei and Jarema Malicki
Nature Genetics 31, 150–157
(June 2002); doi:10.1038/ng883
| Abstract | Full Text (HTML/PDF) |
May
letters to nature
Functional relationship of cytochrome c6 and plastocyanin in Arabidopsis
Rajeev Gupta, Zengyong He and Sheng Luan
Nature 417, 567–571
(May 2002); doi:10.1038/417567a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation
Christelle Forcet, Elke Stein, Laurent Pays, Véronique Corset, Fabien Llambi, Marc Tessier-Lavigne and Patrick Mehlen
Nature 417, 443–447
(May 2002); doi:10.1038/nature748
| First Paragraph | Full Text (HTML/PDF) |
news and views
A role for Toll in autoimmunity
Arthur M. Krieg
Nature Immunology 3, 423–424
(May 2002); doi:10.1038/ni0502-423
| Full Text (HTML/PDF) |
letters to nature
A common mechanism of action for three mood-stabilizing drugs
Robin S. B. Williams, Lili Cheng, Anne W. Mudge and Adrian J. Harwood
Nature 417, 292–295
(May 2002); doi:10.1038/417292a
| First Paragraph | Full Text (HTML/PDF) |
news and views
A new blueprint for plant pathogen resistance
Heribert Hirt
Nature Biotechnology 20, 450–451
(May 2002); doi:10.1038/nbt0502-450
| Full Text (HTML/PDF) |
research article
An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
Paolo Michieli, Silvia Cavassa, Cristina Basilico, Annarita De Luca, Massimiliano Mazzone, Cinzia Asti, Riccardo Chiusaroli, Mario Guglielmi, Paola Bossù, Francesco Colotta, Gianfranco Caselli and Paolo M. Comoglio
Nature Biotechnology 20, 488–495
(May 2002); doi:10.1038/nbt0502-488
| Abstract | Full Text (HTML/PDF) |
article
Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling
Andrés Couve, Philip Thomas, Andrew R. Calver, Warren D. Hirst, Menelas N. Pangalos, Frank S. Walsh, Trevor G. Smart and Stephen J. Moss
Nature Neuroscience 5, 415–424
(May 2002); doi:10.1038/nn833
| Abstract | Full Text (HTML/PDF) |
article
A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth
Hung-Teh Kao, Hong-jun Song, Barbara Porton, Guo-li Ming, Josephine Hoh, Michael Abraham, Andrew J. Czernik, Vincent A. Pieribone, Mu-ming Poo and Paul Greengard
Nature Neuroscience 5, 431–437
(May 2002); doi:10.1038/nn840
| Abstract | Full Text (HTML/PDF) |
review article
ONCOGENIC TYROSINE KINASES AND THE DNA-DAMAGE RESPONSE
Tomasz Skorski
Nature Reviews Cancer 2, 351–360
(May 2002); doi:10.1038/nrc799
| Abstract | Full Text (HTML/PDF) |
historical perspective
The origins of protein phosphorylation
Philip Cohen
Nature Cell Biology 4, E127
(May 2002); doi:10.1038/ncb0502-e127
| Abstract | Full Text (HTML/PDF) |
historical perspective
The origins of protein phosphorylation
Philip Cohen
Nature Cell Biology 4, E127
(May 2002); doi:10.1038/ncb0502-e127
| Abstract | Full Text (HTML/PDF) |
article
Par-1 regulates stability of the posterior determinant Oskar by phosphorylation
Veit Riechmann, Gustavo J. Gutierrez, Paolo Filardo, Angel R. Nebreda and Anne Ephrussi
Nature Cell Biology 4, 337–342
(May 2002); doi:10.1038/ncb782
| Abstract | Full Text (HTML/PDF) |
news and views
Cell polarity: Oskar seeks PARtner for a stable relationship
Simon L. Bullock and David Ish-Horowicz
Nature Cell Biology 4, E117
(May 2002); doi:10.1038/ncb0502-e117
| Full Text (HTML/PDF) |
article
ErbB2 is essential in the prevention of dilated cardiomyopathy
Steven A. Crone, You-Yang Zhao, Lian Fan, Yusu Gu, Susumu Minamisawa, Yang Liu, Kirk L. Peterson, Ju Chen, Ronald Kahn, Gianluigi Condorelli, John Ross Jr, Kenneth R. Chien and Kuo-Fen Lee
Nature Medicine 8, 459–465
(May 2002); doi:10.1038/nm0502-459
| Abstract | Full Text (HTML/PDF) |
letter
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo
Edwina C. Lerner and Thomas E. Smithgall
Nature Structural Biology 9, 365–369
(May 2002); doi:10.1038/nsb782
| Abstract | Full Text (HTML/PDF) |
April
brief communication
Protein kinase Mz is necessary and sufficient for LTP maintenance
Douglas S.F. Ling, Larry S. Benardo, Peter A. Serrano, Nancy Blace, Matthew T. Kelly, John F. Crary and Todd C. Sacktor
Nature Neuroscience 5, 295–296
(April 2002); doi:10.1038/nn829
| First Paragraph | Full Text (HTML/PDF) |
news and views
Flies put the buzz back into long-term-potentiation
Ole Paulsen and Richard G. M. Morris
Nature Neuroscience 5, 289–290
(April 2002); doi:10.1038/nn0402-289
| Full Text (HTML/PDF) |
article
Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster
Eric A. Drier, Marcela K. Tello, Maureen Cowan, Priscilla Wu, Nancy Blace, Todd Charlton Sacktor and Jerry C.P. Yin
Nature Neuroscience 5, 316–324
(April 2002); doi:10.1038/nn820
| Abstract | Full Text (HTML/PDF) |
letter
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
Christopher Pargellis, Liang Tong, Laurie Churchill, Pier F. Cirillo, Thomas Gilmore, Anne G. Graham, Peter M. Grob, Eugene R. Hickey, Neil Moss, Susan Pav and John Regan
Nature Structural Biology 9, 268–272
(April 2002); doi:10.1038/nsb770
| First Paragraph | Full Text (HTML/PDF) |
letter
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase
Madhusudan, Pearl Akamine, Nguyen-Huu Xuong and Susan S. Taylor
Nature Structural Biology 9, 273–277
(April 2002); doi:10.1038/nsb780
| First Paragraph | Full Text (HTML/PDF) |
research article
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
Birgit Schoeberl, Claudia Eichler-Jonsson, Ernst Dieter Gilles and Gertraud Müller
Nature Biotechnology 20, 370–375
(April 2002); doi:10.1038/nbt0402-370
| Abstract | Full Text (HTML/PDF) |
Research News
Trading “wet-work” for network
Vipul Periwal and Zoltan Szallasi
Nature Biotechnology 20, 345–346
(April 2002); doi:10.1038/nbt0402-345
| Full Text (HTML/PDF) |
perspectives
TIMELINE: Protein kinases — the major drug targets of the twenty-first century?
Philip Cohen
Nature Reviews Drug Discovery 1, 309–315
(April 2002); doi:10.1038/nrd773
| Abstract | Full Text (HTML/PDF) |
review article
V-SRC'S HOLD OVER ACTIN AND CELL ADHESIONS
Margaret C. Frame, Valerie J. Fincham, Neil O. Carragher and John A. Wyke
Nature Reviews Molecular Cell Biology 3, 233–245
(April 2002); doi:10.1038/nrm779
| Abstract | Full Text (HTML/PDF) |
review article
CLOSING IN ON THE BIOLOGICAL FUNCTIONS OF FPS/FES AND FER
Peter Greer
Nature Reviews Molecular Cell Biology 3, 278–289
(April 2002); doi:10.1038/nrm783
| Abstract | Full Text (HTML/PDF) |
news and views
E-cadherin and Hakai: signalling, remodeling or destruction?
Salvatore Pece and J. Silvio Gutkind
Nature Cell Biology 4, E72
(April 2002); doi:10.1038/ncb0402-e72
| Full Text (HTML/PDF) |
news and views
Ready and Abl
Sarah Greaves
Nature Cell Biology 4, E74
(April 2002); doi:10.1038/ncb0402-e74
| Full Text (HTML/PDF) |
news and views
Integrin regulation of growth factor receptors
Kenneth M. Yamada and Sharona Even-Ram
Nature Cell Biology 4, E75
(April 2002); doi:10.1038/ncb0402-e75
| Full Text (HTML/PDF) |
letters to nature
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
Jianhang Jia, Kazuhito Amanai, Gelin Wang, Jiong Tang, Bing Wang and Jin Jiang
Nature 416, 548–552
(April 2002); doi:10.1038/nature733
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letters to nature
Protein kinase Cd controls self-antigen-induced B-cell tolerance
Ingrid Mecklenbräuker, Kaoru Saijo, Nai-Ying Zheng, Michael Leitges and Alexander Tarakhovsky
Nature 416, 860–865
(April 2002); doi:10.1038/416860a
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letters to nature
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cd
Akitomo Miyamoto, Keiko Nakayama, Hiroyuki Imaki, Sachiko Hirose, Yi Jiang, Masaaki Abe, Tadasuke Tsukiyama, Hiroyasu Nagahama, Shigeo Ohno, Shigetsugu Hatakeyama and Keiichi I. Nakayama
Nature 416, 865–869
(April 2002); doi:10.1038/416865a
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March
review article
PHOSPHOTYROSINE-BINDING DOMAINS IN SIGNAL TRANSDUCTION
Michael B. Yaffe
Nature Reviews Molecular Cell Biology 3, 177–186
(March 2002); doi:10.1038/nrm759
| Abstract | Full Text (HTML/PDF) |
review article
MECHANISMS OF AGEING: PUBLIC OR PRIVATE?
Linda Partridge and David Gems
Nature Reviews Genetics 3, 165–175
(March 2002); doi:10.1038/nrg753
| Abstract | Full Text (HTML/PDF) |
review article
THE MOLECULAR BASIS OF CaMKII FUNCTION IN SYNAPTIC AND BEHAVIOURAL MEMORY
John Lisman, Howard Schulman and Hollis Cline
Nature Reviews Neuroscience 3, 175–190
(March 2002); doi:10.1038/nrn753
| Abstract | Full Text (HTML/PDF) |
brief communication
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
Thomas Radimerski, Jacques Montagne, Felix Rintelen, Hugo Stocker, Jeroen van der Kaay, C. Peter Downes, Ernst Hafen and George Thomas
Nature Cell Biology 4, 251–255
(3); doi:10.1038/ncb763
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article
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Tzong-Shyuan Lee and Lee-Young Chau
Nature Medicine 8, 240–246
(March 2002); doi:10.1038/nm0302-240
| Abstract | Full Text (HTML/PDF) |
article
Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
Rama Pai, Brian Soreghan, Imre L. Szabo, Meredith Pavelka, Dolgor Baatar and Andrzej S. Tarnawski
Nature Medicine 8, 289–293
(March 2002); doi:10.1038/nm0302-289
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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
Ronit I. Yarden, Sherly Pardo-Reoyo, Magda Sgagias, Kenneth H. Cowan and Lawrence C. Brody
Nature Genetics 30, 285–289
(March 2002); doi:10.1038/ng837
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letter
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
Jacob Falck, John H.J. Petrini, Bret R. Williams, Jiri Lukas and Jiri Bartek
Nature Genetics 30, 290–294
(March 2002); doi:10.1038/ng845
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research article
Fluorescent indicators for imaging protein phosphorylation in single living cells
Moritoshi Sato, Takeaki Ozawa, Kouichi Inukai, Tomoichiro Asano and Yoshio Umezawa
Nature Biotechnology 20, 287–294
(March 2002); doi:10.1038/nbt0302-287
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letters to nature
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi, Naohiro Inohara, Lorraine D. Hernandez, Jorge E. Galán, Gabriel Núñez, Charles A. Janeway, Ruslan Medzhitov and Richard A. Flavell
Nature 416, 194–199
(March 2002); doi:10.1038/416194a
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February
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An essential link to mammary cancer?
Sibylle Tonko-Geymayer and Wolfgang Doppler
Nature Medicine 8, 108–110
(February 2002); doi:10.1038/nm0202-108
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article
Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition
Eiichi Okumura, Takeshi Fukuhara, Hitoshi Yoshida, Shin-ichiro Hanada, Rie Kozutsumi, Masashi Mori, Kazunori Tachibana and Takeo Kishimoto
Nature Cell Biology 4, 111–116
(February 2002); doi:10.1038/ncb741
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letters to nature
S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
Hiroshi Masumoto, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki
Nature 415, 651–655
(February 2002); doi:10.1038/nature713
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article
MAP kinase signalling cascade in Arabidopsis innate immunity
Tsuneaki Asai, Guillaume Tena, Joulia Plotnikova, Matthew R. Willmann, Wan-Ling Chiu, Lourdes Gomez-Gomez, Thomas Boller, Frederick M. Ausubel and Jen Sheen
Nature 415, 977–983
(February 2002); doi:10.1038/415977a
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letter
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
Ikuko Hayashi, Kristiina Vuori and Robert C. Liddington
Nature Structural Biology 9, 101–106
(February 2002); doi:10.1038/nsb755
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letter
Structure of the Bcr-Abl oncoprotein oligomerization domain
Xun Zhao, Saghi Ghaffari, Harvey Lodish, Vladimir N. Malashkevich and Peter S. Kim
Nature Structural Biology 9, 117–120
(February 2002); doi:10.1038/nsb747
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January
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Diabetes: Fat in all the wrong places
Jeffrey Friedman
Nature 415, 268–269
(January 2002); doi:10.1038/415268a
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letters to nature
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Yasuhiko Minokoshi, Young-Bum Kim, Odile D. Peroni, Lee G. D. Fryer, Corinna Müller, David Carling and Barbara B. Kahn
Nature 415, 339–343
(January 2002); doi:10.1038/415339a
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news and views
Reach for the stars
Sarah Greaves
Nature Cell Biology 4, E12
(January 2002); doi:10.1038/ncb0102-e12
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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
Thomas G. Hofmann, Andreas Möller, Hüseyin Sirma, Hanswalter Zentgraf, Yoichi Taya, Wulf Dröge, Hans Will and M. Lienhard Schmitz
Nature Cell Biology 4, 1–10
(January 2002); doi:10.1038/ncb715
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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
Gabriella D'Orazi, Barbara Cecchinelli, Tiziana Bruno, Isabella Manni, Yuichiro Higashimoto, Shin'ichi Saito, Monica Gostissa, Sabrina Coen, Alessandra Marchetti, Giannino Del Sal, Giulia Piaggio, Maurizio Fanciulli, Ettore Appella and Silvia Soddu
Nature Cell Biology 4, 11–19
(January 2002); doi:10.1038/ncb714
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article
TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase
Chuan-Wei Jang, Chun-Hau Chen, Chun-Chieh Chen, Jia-yun Chen, Yi-Hsien Su and Ruey-Hwa Chen
Nature Cell Biology 4, 51–58
(January 2002); doi:10.1038/ncb731
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review article
TRANSCRIPTION: MAPK-REGULATED TRANSCRIPTION: A CONTINUOUSLY VARIABLE GENE SWITCH?
Catherine A. Hazzalin and Louis C. Mahadevan
Nature Reviews Molecular Cell Biology 3, 30–40
(January 2002); doi:10.1038/nrm715
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article
Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils
Isabelle Daigle, Shida Yousefi, Marco Colonna, Douglas R. Green and Hans-Uwe Simon
Nature Medicine 8, 61–67
(January 2002); doi:10.1038/nm0102-61
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article
BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2
Danilo Perrotti, Vincenzo Cesi, Rossana Trotta, Clara Guerzoni, Giorgia Santilli, Kenneth Campbell, Angela Iervolino, Fabrizio Condorelli, Carlo Gambacorti-Passerini, Michael A. Caligiuri and Bruno Calabretta
Nature Genetics 30, 48–58
(January 2002); doi:10.1038/ng791
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Novel effector function for an old receptor
Rüdiger Klein
Nature Cell Biology 4, E11
(January 2002); doi:10.1038/ncb0102-e11
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p38-dependent marking of inflammatory genes for increased NF-kB recruitment
Simona Saccani, Serafino Pantano and Gioacchino Natoli
Nature Immunology 3, 69–75
(January 2002); doi:10.1038/ni748
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Preparing the target for the bullet
Kathrin Muegge
Nature Immunology 3, 16–17
(January 2002); doi:10.1038/ni0102-16
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news and views
Diabetes: Fat in all the wrong places
Jeffrey Friedman
Nature 415, 268–269
(January 2002); doi:10.1038/415268a
| Full Text (HTML/PDF) |
letters to nature
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Yasuhiko Minokoshi, Young-Bum Kim, Odile D. Peroni, Lee G. D. Fryer, Corinna Müller, David Carling and Barbara B. Kahn
Nature 415, 339–343
(January 2002); doi:10.1038/415339a
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