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December

letter
Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres
Julie M. Bailis, Pascal Bernard, Richard Antonelli, Robin C. Allshire and Susan L. Forsburg
Nature Cell Biology 5, 1111–1116
(December 2003); doi:10.1038/ncb1069
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letter
Pyruvate kinase deficiency in mice protects against malaria
Gundula Min-Oo, Anny Fortin, Mi-Fong Tam, André Nantel, Mary M Stevenson and Philippe Gros
Nature Genetics 35, 357–362
(December 2003); doi:10.1038/ng1260
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article
Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation
Weiping Zheng, Zhongsen Zhang, Surajit Ganguly, Joan L Weller, David C Klein and Philip A Cole
Nature Structural Biology 10, 1054–1057
(December 2003); doi:10.1038/nsb1005
| Abstract | Full Text (HTML/PDF) |

brief communication
Genetics: Influence of TOR kinase on lifespan in C. elegans
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L. Kovacs, László Orosz and Fritz Müller
Nature 426, 620
(11 December 2003); doi:10.1038/426620a
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letter
Securin and B-cyclin/CDK are the only essential targets of the APC
Brian R. Thornton and David P. Toczyski
Nature Cell Biology 5, 1090–1094
(December 2003); doi:10.1038/ncb1066
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review article
Met, metastasis, motility and more
Carmen Birchmeier , Walter Birchmeier , Ermanno Gherardi and George F. Vande Woude
Nature Reviews Molecular Cell Biology 4, 915–925
(December 2003); doi:10.1038/nrm1261
| Abstract | Full Text (HTML / PDF) |

perspectives
Opinion: Lateral phosphorylation propagation: an aspect of feedback signalling?
Christian Tischer and Philippe I. H. Bastiaens
Nature Reviews Molecular Cell Biology 4, 971–975
(December 2003); doi:10.1038/nrm1258
| Abstract | Full Text (HTML / PDF) |

review article
CD28-mediated co-stimulation: a quantitative support for TCR signalling
Oreste Acuto and Frédérique Michel
Nature Reviews Immunology 3, 939–951
(December 2003); doi:10.1038/nri1248
| Abstract | Full Text (HTML / PDF) |

letter
WNK4 regulates the balance between renal NaCl reabsorption and K⁺ secretion
Kristopher T Kahle, Frederick H Wilson, Qiang Leng, Maria D Lalioti, Anthony D O'Connell, Ke Dong, Alicia K Rapson, Gordon G MacGregor, Gerhard Giebisch, Steven C Hebert and Richard P Lifton
Nature Genetics 35, 372–376
(December 2003); doi:10.1038/ng1271
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news and views
A molecular switch controlling renal sodium and potassium excretion
René J M Bindels
Nature Genetics 35, 302–303
(December 2003); doi:10.1038/ng1203-302
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letters to nature
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
Kristina Lorenz, Martin J. Lohse and Ursula Quitterer
Nature 426, 574–579
(04 December 2003); doi:10.1038/nature02158
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letters to nature
Release of eIF6 (p27^BBP) from the 60S subunit allows 80S ribosome assembly
Marcello Ceci, Cristina Gaviraghi, Chiara Gorrini, Leonardo A. Sala, Nina Offenhäuser, Pier Carlo Marchisio and Stefano Biffo
Nature 426, 579–584
(04 December 2003); doi:10.1038/nature02160
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letter
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
Mark T. Uhlik, Amy N. Abell, Nancy L. Johnson, Weiyong Sun, Bruce D. Cuevas, Katherine E. Lobel-Rice, Eric A. Horne, Mark L. Dell'Acqua and Gary L. Johnson
Nature Cell Biology 5, 1104–1110
(December 2003); doi:10.1038/ncb1071
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news and views
JAKing up immunosuppression
Megan Sykes
Nature Medicine 9, 1458–1459
(December 2003); doi:10.1038/nm1203-1458
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article
Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration
Amitabh Gupta, Kamon Sanada, David T Miyamoto, Susan Rovelstad, Bagirathy Nadarajah, Alan L Pearlman, Jan Brunstrom and Li-Huei Tsai
Nature Neuroscience 6, 1284–1291
(December 2003); doi:10.1038/nn1151
| Abstract | Full Text (HTML/PDF) |

November

letters to nature
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
Wen Xiong and James E. Ferrell Jr
Nature 426, 460–465
(27 November 2003); doi:10.1038/nature02089
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news and views
Cell biology: Thanks for the memory
Jill C. Sible
Nature 426, 392–393
(November 2003); doi:10.1038/426392a
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letters to nature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Takashi Nomura, Tomoyuki Tagami, Sayuri Yamazaki, Toshiko Sakihama, Takaji Matsutani, Izumi Negishi, Syuichi Nakatsuru & Shimon Sakaguchi
Nature 426, 454–460
(27 November 2003); doi:10.1038/nature02119
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article
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
Omar D Perez, Dennis Mitchell, Gina C Jager, Sharon South, Chris Murriel, Jacqueline McBride, Lee A Herzenberg, Shigemi Kinoshita and Garry P Nolan
Nature Immunology 4, 1083–1092
(November 2003); doi:10.1038/ni984
| Abstract | Full Text (HTML/PDF) |

news and views
LFA-1: more than just T cell Velcro
Yoji Shimizu
Nature Immunology 4, 1052–1054
(November 2003); doi:10.1038/ni1103-1052
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letters to nature
Testis determination requires insulin receptor family function in mice
Serge Nef , Sunita Verma-Kurvari, Jussi Merenmies, Jean-Dominique Vassalli, Argiris Efstratiadis, Domenico Accili and Luis F. Parada
Nature 426, 291–295
(20 November 2003); doi:10.1038/nature02059
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news and views
Developmental biology: Gender benders
Peter Koopman
Nature 426, 241
(20 November 2003); doi:10.1038/426241a
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letters to nature
A DNA damage checkpoint response in telomere-initiated senescence
Fabrizio d'Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas von Zglinicki, Gabriele Saretzki, Nigel P. Carter and Stephen P. Jackson
Nature 426, 194–198
(13 November 2003); doi:10.1038/nature02118
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letters to nature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
Luca Busino, Maddalena Donzelli, Massimo Chiesa, Daniele Guardavaccaro, Dvora Ganoth, N. Valerio Dorrello, Avram Hershko, Michele Pagano and Giulio F. Draetta
Nature 426, 87–91
(06 November 2003); doi:10.1038/nature02082
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review article
The cellular geography of Aurora kinases
Mar Carmena and William C. Earnshaw
Nature Reviews Molecular Cell Biology 4, 842–854
(November 2003); doi:10.1038/nrm1245
| Summary | Full Text (HTML / PDF) |

review article
Regulation of JAK-STAT signalling in the immune system
Ke Shuai and Bin Liu
Nature Reviews Immunology 3, 900–911
(November 2003); doi:10.1038/nri1226
| Summary | Full Text (HTML / PDF) |

article
Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss
Suzhen Chen, Carlos Rio, Ru-Rong Ji, Pieter Dikkes, Richard E Coggeshall, Clifford J Woolf and Gabriel Corfas
Nature Neuroscience 6, 1186–1193
(November 2003); doi:10.1038/nn1139
| Abstract | Full Text (HTML/PDF) |

article
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
Rong Rong, Jee-Yin Ahn, Honglian Huang, Eiichiro Nagata, Daniel Kalman, Judith A Kapp, Jiancheng Tu, Paul F Worley, Solomon H Snyder and Keqiang Ye
Nature Neuroscience 6, 1153–1161
(November 2003); doi:10.1038/nn1134
| Abstract | Full Text (HTML/PDF) |

October

letters to nature
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Anna V. Molofsky, Ricardo Pardal, Toshihide Iwashita, In-Kyung Park, Michael F. Clarke and Sean J. Morrison
Nature 425, 962–967
(30 October 2003); doi:10.1038/nature02060
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letters to nature
ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin
Benoît Biteau, Jean Labarre and Michel B. Toledano
Nature 425, 980–984
(30 October 2003); doi:10.1038/nature02075
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letter
LKB1 (XEEK1) regulates Wnt signalling in vertebrate development
Olga Ossipova, Nabeel Bardeesy, Ronald A. DePinho and Jeremy B. A. Green
Nature Cell Biology 5, 889–894
(October 2003); doi:10.1038/ncb1048
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news and views
Wnt signalling gets XEEKy
Wilson K. Clements and David Kimelman
Nature Cell Biology 5, 861–863
(October 2003); doi:10.1038/ncb1003-861
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news and views
Timing the cell cycle
Peter K. Jackson
Nature Cell Biology 5, 859–861
(October 2003); doi:10.1038/ncb1003-859
| Full Text (HTML/PDF) |

review article
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
Pablo Engel, Michael J. Eck and Cox Terhorst
Nature Reviews Immunology 3, 813–821
(October 2003); doi:10.1038/nri1202
| Abstract | Full Text (HTML / PDF) |

article
Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
Jian Wang, ShuHong Liu, YangPing Fu, Jerry H Wang and YouMing Lu
Nature Neuroscience 6, 1039–1047
(October 2003); doi:10.1038/nn1119
| Abstract | Full Text (HTML/PDF) |

letters to nature
Targets of the cyclin-dependent kinase Cdk1
Jeffrey A. Ubersax, Erika L. Woodbury, Phuong N. Quang, Maria Paraz, Justin D. Blethrow, Kavita Shah, Kevan M. Shokat and David O. Morgan
Nature 425, 859–864
(23 October 2003); doi:10.1038/nature02062
| First Paragraph | Full Text (HTML / PDF) |

letter
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
Sophie Pantalacci, Nicolas Tapon and Pierre Léopold
Nature Cell Biology 5,921–927
(October 2003); doi:10.1038/ncb1051
| Abstract | Full Text (HTML/PDF) |

letter
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
Ryan S. Udan, Madhuri Kango-Singh, Riitta Nolo, Chunyao Tao and Georg Halder
Nature Cell Biology 5, 914–920
(October 2003); doi:10.1038/ncb1050
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news and views
Hippo and its mission for growth control
Hyung Don Ryoo and Hermann Steller
Nature Cell Biology 5, 853–855
(October 2003); doi:10.1038/ncb1003-853
| Full Text (HTML/PDF) |

article
NF-kB functions in synaptic signaling and behavior
Mollie K Meffert, Jolene M Chang, Brian J Wiltgen, Michael S Fanselow and David Baltimore
Nature Neuroscience 6, 1072–1078
(October 2003); doi:10.1038/nn1110
| Abstract | Full Text (HTML/PDF) |

review article
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Rik Derynck and Ying E. Zhang
Nature 425, 577–584
(09 October 2003); doi:10.1038/nature02006
| Abstract | Full Text (HTML / PDF) |

news and views
Eat your proteins—live longer
Evelyn Jabri
Nature Structural Biology 10, 780
(October 2003); doi:10.1038/nsb1003-780
| Full Text (HTML/PDF) |

letters to nature
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers
Hsiu-Hsiang Lee, Audra Norris, Joseph B. Weiss and Manfred Frasch
Nature 425, 507–512
(02 October 2003); doi:10.1038/nature01916
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letters to nature
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
Camilla Englund, Christina E. Lorén, Caroline Grabbe, Gaurav K. Varshney, Fabienne Deleuil, Bengt Hallberg and Ruth H. Palmer
Nature 425, 512–516
(02 October 2003); doi:10.1038/nature01950
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news and views
Developmental biology: Partners united
Matthew Freeman
Nature 425, 468–469
(02 October 2003); doi:10.1038/425468a
| Full Text (HTML / PDF) |

article
EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
Manuel Zimmer, Amparo Palmer, Jenny Köhler and Rüdiger Klein
Nature Cell Biology 5, 869–878
(October 2003); doi:10.1038/ncb1045
| Abstract | Full Text (HTML/PDF) |

article
Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
Daniel J. Marston, Sarah Dickinson and Catherine D. Nobes
Nature Cell Biology 5, 879–888
(October 2003); doi:10.1038/ncb1044
| Abstract | Full Text (HTML/PDF) |

news and views
How attraction turns to repulsion
David G. Wilkinson
Nature Cell Biology 5, 851–853
(October 2003); doi:10.1038/ncb1003-851
| Full Text (HTML/PDF) |

brief communication
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer
H. Rosie Xing, Carlos Cordon-Cardo, Xinzhu Deng, William Tong, Luis Campodonico, Zvi Fuks and Richard Kolesnick
Nature Medicine 9, 1267–1268
(October 2003); doi:10.1038/nm927
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September

article
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
Tiziana Borsello, Peter G. H. Clarke, Lorenz Hirt, Alessandro Vercelli, Mariaelena Repici, Daniel F. Schorderet, Julien Bogousslavsky and Christophe Bonny
Nature Medicine 9, 1180–1186
(September 2003); doi:10.1038/nm911
| Abstract | Full Text (HTML/PDF) |

review article
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
Sanjay Kumar, Jeffrey Boehm and John C. Lee
Nature Reviews Drug Discovery 2, 717–726
(September 2003); doi:10.1038/nrd1177
| Abstract | Full Text (HTML / PDF) |

review article
Titin: properties and family relationships
Larissa Tskhovrebova and John Trinick
Nature Reviews Molecular Cell Biology 4, 679–689
(September 2003); doi:10.1038/nrm1198
| Abstract | Full Text (HTML / PDF) |

research article
Phosphospecific proteolysis for mapping sites of protein phosphorylation
Zachary A. Knight, Birgit Schilling, Richard H. Row, Denise M. Kenski, Bradford W. Gibson and Kevan M. Shokat
Nature Biotechnology 21, 1047–1054
(September 2003); doi:10.1038/nbt863
| Abstract | Full Text (HTML/PDF) |

article
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
Abeel A. Mangi, Nicolas Noiseux, Deling Kong, Huamei He, Mojgan Rezvani, Joanne S. Ingwall and Victor J. Dzau
Nature Medicine 9, 1195–1201
(September 2003); doi:10.1038/nm912
| Abstract | Full Text (HTML/PDF) |

news and views
Akt helps stem cells heal the heart
Omer N Koç and Stanton L. Gerson
Nature Medicine 9, 1109–1110
(September 2003); doi:10.1038/nm0903-1109
| Full Text (HTML/PDF) |

article
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
Sagrario Ortega, Ignacio Prieto, Junko Odajima, Alberto Martín, Pierre Dubus, Rocio Sotillo, Jose Luis Barbero, Marcos Malumbres and Mariano Barbacid
Nature Genetics 35, 25–31
(September 2003); doi:10.1038/ng1232
| Abstract | Full Text (HTML/PDF) |

news and views
Bared essentials of CDK2 and cyclin E
James M. Roberts and Charles J. Sherr
Nature Genetics 35, 8–9
(September 2003); doi:10.1038/ng1234
| Full Text (HTML/PDF) |

review article
14-3-3 proteins in the nervous system
Daniela Berg , Carsten Holzmann and Olaf Riess
Nature Reviews Neuroscience 4, 752–762
(September 2003); doi:10.1038/nrn1197
| Abstract | Full Text (HTML / PDF) |

article
Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
Catherine E Fitzgerald, Sangita B Patel, Joseph W Becker, Patricia M Cameron, Dennis Zaller, Vasilis Bill Pikounis, Stephen J O'Keefe and Giovanna Scapin
Nature Structural Biology 10, 764–769
(September 2003); doi:10.1038/nsb949
| Abstract | Full Text (HTML/PDF) |

review article
The role of FLT3 in haematopoietic malignancies
Derek L. Stirewalt and Jerald P. Radich
Nature Reviews Cancer 3, 650–665
(September 2003); doi:10.1038/nrc1169
| Abstract | Full Text (HTML / PDF) |

article
Enhanced T cell responses due to diacylglycerol kinase ζ deficiency
Xiao-Ping Zhong, Ehmonie A. Hainey, Benjamin A. Olenchock, Martha S. Jordan, Jonathan S. Maltzman, Kim E. Nichols, Hao Shen and Gary A. Koretzky
Nature Immunology 4, 882–890
(September 2003); doi:10.1038/ni958
| Abstract | Full Text (HTML/PDF) |

August

article
Cdk5 is essential for synaptic vesicle endocytosis
Timothy C. Tan, Valentina A. Valova, Chandra S. Malladi, Mark E. Graham, Leise A. Berven, Orla J. Jupp, Gurdip Hansra, Sonya J. McClure, Boris Sarcevic, Ross A. Boadle, Martin R. Larsen, Michael A. Cousin and Phillip J. Robinson
Nature Cell Biology 5, 701–710
(August 2003); doi:10.1038/ncb1020
| Abstract | Full Text (HTML/PDF) |

news and views
Cdk5 is a dynamo at the synapse
Benjamin Adam Samuels and Li-Huei Tsai
Nature Cell Biology 5, 689–690
(August 2003); doi:10.1038/ncb0803-689
| Full Text (HTML/PDF) |

article
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
Andrew R. Hallahan, Joel I. Pritchard, Roshantha A. S. Chandraratna, Richard G. Ellenbogen, J. Russel Geyer, Ryan P. Overland, Andrew D. Strand, Stephen J. Tapscott and James M. Olson
Nature Medicine 9, 1033–1038
(August 2003); doi:10.1038/nm904
| Abstract | Full Text (HTML/PDF) |

news and views
Anthrax delivers a lethal blow to host immunity
Michael N. Starnbach and R. John Collier
Nature Medicine 9, 996–997
(August 2003); doi:10.1038/nm0803-996
| Full Text (HTML/PDF) |

letters to nature
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Nika N. Danial, Colette F. Gramm, Luca Scorrano, Chen-Yu Zhang, Stefan Krauss, Ann M. Ranger, Sandeep Robert Datta, Michael E. Greenberg, Lawrence J. Licklider, Bradford B. Lowell, Steven P. Gygi and Stanley J. Korsmeyer
Nature 424, 952–956
(21 August 2003); doi:10.1038/nature01825
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cell biology: Metabolism meets death
Julian Downward
Nature 424, 896–897
(21 August 2003); doi:10.1038/424896a
| Full Text (HTML / PDF) |

letters to nature
Feedback regulation of MAPK signalling by an RNA-binding protein
Reiko Sugiura, Ayako Kita, Yasuhito Shimizu, Hisato Shuntoh, Susie O. Sio and Takayoshi Kuno
Nature 424, 961–965
(21 August 2003); doi:10.1038/nature01907
| First Paragraph | Full Text (HTML / PDF) |

article
Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development
Christian A. J. Voßhenrich, Ana Cumano, Werner Müller, James P. Di Santo and Paulo Vieira
Nature Immunology 4, 773–779
(August 2003); doi:10.1038/ni956
| Abstract | Full Text (HTML/PDF) |

brief communication
Cell signalling (communication arising): Cell survival and a Gadd45-factor deficiency
Arshad Amanullah, Naiyer Azam, Arthur Balliet, Christine Hollander, Barbara Hoffman, Albert Fornace Jr and Dan Liebermann
Nature 424, 741
(14 August 2003); doi:10.1038/424741b
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letter
Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint
Eunah Chung and Rey-Huei Chen
Nature Cell Biology 5, 748–753
(August 2003); doi:10.1038/ncb1022
| First Paragraph | Full Text (HTML/PDF) |

perspectives
Opinion: Transactivation joins multiple tracks to the ERK/MAPK cascade
Reinhard Wetzker and Frank-D. Böhmer
Nature Reviews Molecular Cell Biology 4, 651–657
(August 2003); doi:10.1038/nrm1173
| Abstract | Full Text (HTML / PDF) |

article
Functional inactivation of a transcriptional corepressor by a signaling kinase
Christopher J Barnes, Ratna K Vadlamudi, Sandip K Mishra, Raymond H Jacobson, Feng Li and Rakesh Kumar
Nature Structural Biology 10, 622–628
(August 2003); doi:10.1038/nsb957
| Abstract | Full Text (HTML/PDF) |

July

article
Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
R. Jeroen Pasterkamp, Jacques J. Peschon, Melanie K. Spriggs and Alex L. Kolodkin
Nature 424, 398–405
(24 July 2003); doi:10.1038/nature01790
| Abstract | Full Text (HTML / PDF) |

news and views
Neurobiology: A new way to network
Patrick Mehlen
Nature 424, 381–382
(24 July 2003); doi:10.1038/424381a
| Full Text (HTML / PDF) |

letters to nature
Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus
Xin Wang, Shu-Mei Huong, Marie L. Chiu, Nancy Raab-Traub and Eng-Shang Huang
Nature 424, 456–461
(24 July 2003); doi:10.1038/nature01818
| First Paragraph | Full Text (HTML / PDF) |

letter
Crosstalk between Rap1 and Rac regulates secretion of sAPPα
Marjorie Maillet, Sylvain J. Robert, Mathias Cacquevel, Monique Gastineau, Denis Vivien, Jacques Bertoglio, José L. Zugaza, Rodolphe Fischmeister and Frank Lezoualc'h
Nature Cell Biology 5, 633–639
(July 2003); doi:10.1038/ncb1007
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news and views
Movin' on through with Cdc2
Rudy Juliano
Nature Cell Biology 5, 589–590
(July 2003); doi:10.1038/ncb0703-589
| Full Text (HTML/PDF) |

article
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Monica Autiero, Johannes Waltenberger, Didier Communi, Andrea Kranz, Lieve Moons, Diether Lambrechts, Jens Kroll, Stephane Plaisance, Maria De Mol, Françoise Bono, Stefanie Kliche, Guido Fellbrich, Kurt Ballmer-Hofer, Domenico Maglione, Ulrike Mayr-Beyrle, Mieke Dewerchin, Saskia Dombrowski, Danica Stanimirovic, Paul Van Hummelen, Christoph Dehio, Daniel J. Hicklin, Graziella Persico, Jean-Marc Herbert, David Communi, Masabumi Shibuya, Désiré Collen, Edward M. Conway and Peter Carmeliet
Nature Medicine 9, 936–943
(July 2003); doi:10.1038/nm884
| Abstract | Full Text (HTML/PDF) |

news and views
Polyglutamine neurodegeneration: minding your Ps and Qs
Henry Paulson
Nature Medicine 9, 825–826
(July 2003); doi:10.1038/nm0703-825
| Full Text (HTML/PDF) |

article
14-3-3 is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
Kazuhito Toyo-oka, Aki Shionoya, Michael J. Gambello, Carlos Cardoso, Richard Leventer, Heather L. Ward, Ramses Ayala, Li-Huei Tsai, William Dobyns, David Ledbetter, Shinji Hirotsune and Anthony Wynshaw-Boris
Nature Genetics 34, 274–285
(July 2003); doi:10.1038/ng1169
| Abstract | Full Text (HTML/PDF) |

article
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction
Alexander J. Finn, Guoping Feng and Ann Marie Pendergast
Nature Neuroscience 6, 717–723
(July 2003); doi:10.1038/nn1071
| Abstract | Full Text (HTML/PDF) |

news and views
Agrin / MuSK signaling: willing and Abl
Steven J. Burden, Christian Fuhrer and Stevan R. Hubbard
Nature Neuroscience 6, 653–654
(July 2003); doi:10.1038/nn0703-653
| Full Text (HTML/PDF) |

letters to nature
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
Sandra S. Diebold, Maria Montoya, Hermann Unger, Lena Alexopoulou, Polly Roy, Linsey E. Haswell, Aymen Al-Shamkhani, Richard Flavell, Persephone Borrow and Caetano Reis e Sousa
Nature 424, 324–328
(17 July 2003); doi:10.1038/nature01783
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letters to nature
Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin
Anshu Agrawal, Jai Lingappa, Stephen H. Leppla, Sudhanshu Agrawal, Abdul Jabbar, Conrad Quinn and Bali Pulendran
Nature 424, 329–334
(17 July 2003); doi:10.1038/nature01794
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article
SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier
Sae-Won Lee, Woo Jean Kim, Yoon Kyung Choi, Hyun Seok Song, Myung Jin Son, Irwin H. Gelman, Yung-Jin Kim and Kyu-Won Kim
Nature Medicine 9, 900–906
(July 2003); doi:10.1038/nm889
| Abstract | Full Text (HTML/PDF) |

news and views
Building up the blood-brain barrier
Peter Rieckmann and Britta Engelhardt
Nature Medicine 9, 828–829
(July 2003); doi:10.1038/nm0703-828
| Full Text (HTML/PDF) |

letters to nature
JNK phosphorylates paxillin and regulates cell migration
Cai Huang, Zenon Rajfur, Christoph Borchers, Michael D. Schaller and Ken Jacobson
Nature 424, 219–223
(10 July 2003); doi:10.1038/nature01745
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letters to nature
Xpd/Ercc2 regulates CAK activity and mitotic progression
Jian Chen, Stéphane Larochelle, Xiaoming Li and Beat Suter
Nature 424, 228–232
(10 July 2003); doi:10.1038/nature01746
| First Paragraph | Full Text (HTML / PDF) |

letter
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
Lindsey A. Allan, Nick Morrice, Suzanne Brady, Gareth Magee, Shalini Pathak and Paul R. Clarke
Nature Cell Biology 5, 647–654
(July 2003); doi:10.1038/ncb1005
| First Paragraph | Full Text (HTML/PDF) |

article
Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea
Christine A Kirvan, Susan E Swedo, Janet S Heuser and Madeleine W Cunningham
Nature Medicine 9, 914–920
(July 2003); doi:10.1038/nm892
| Abstract | Full Text (HTML/PDF) |

news and views
Letting antibodies get to your head
Robert S Fujinami and Thayne L Sweeten
Nature Medicine 9, 823–825
(July 2003); doi:10.1038/nm0703-823
| Full Text (HTML/PDF) |

review article
Targeting JNK for therapeutic benefit: from junk to gold?
Anthony M. Manning and Roger J. Davis
Nature Reviews Drug Discovery 2, 554–565
(July 2003); doi:10.1038/nrd1132
| Summary | Full Text (HTML / PDF) |

article
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy
Elisabetta Sabini, Stephan Ort, Christian Monnerjahn, Manfred Konrad and Arnon Lavie
Nature Structural Biology 10, 513–519
(July 2003); doi:10.1038/nsb942
| Abstract | Full Text (HTML/PDF) |

article
Deletion of cytosolic phospholipase A₂ promotes striated muscle growth
Syed Haq, Heiko Kilter, Ashour Michael, Jingzang Tao, Eileen O'Leary, Xio Ming Sun, Brian Walters, Kausik Bhattacharya, Xin Chen, Lei Cui, Michele Andreucci, Anthony Rosenzweig, J. Luis Guerrero, Richard Patten, Ronglih Liao, Jeffery Molkentin, Michael Picard, Joseph V. Bonventre and Thomas Force
Nature Medicine 9, 944–951
(July 2003); doi:10.1038/nm891
| Abstract | Full Text (HTML/PDF) |

research article
A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization
Atique Ahmed, Jill Thompson, Lisa Emiliusen, Stephen Murphy, R Daniel Beauchamp, Kaori Suzuki, Ramon Alemany, Kevin Harrington and Richard G Vile
Nature Biotechnology 21, 771–777
(July 2003); doi:10.1038/nbt835
| Abstract | Full Text (HTML/PDF) |

news and views
Vectorology recapitulates virology—will it capitulate oncology?
Estaurdo Aguilar-Cordova
Nature Biotechnology 21, 756–757
(July 2003); doi:10.1038/nbt0703-756
| Full Text (HTML/PDF) |

June

letters to nature
Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast
May C. Morris, Peter Kaiser, Stanislav Rudyak, Chris Baskerville, Mark H. Watson and Steven I. Reed
Nature 423, 1009–1013
(26 June 2003); doi:10.1038/nature01720
| First Paragraph | Full Text (HTML / PDF) |

letter
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
Hugo Stocker, Thomas Radimerski, Benno Schindelholz, Franz Wittwer, Priyanka Belawat, Pierre Daram, Sebastian Breuer, George Thomas and Ernst Hafen
Nature Cell Biology 5, 559–566
(June 2003); doi:10.1038/ncb995
| First Paragraph | Full Text (HTML/PDF) |

letter
Rheb promotes cell growth as a component of the insulin/TOR signalling network
Leslie J. Saucedo, Xinsheng Gao, Dominic A. Chiarelli, Ling Li, Duoija Pan and Bruce A. Edgar
Nature Cell Biology 5, 566–571
(June 2003); doi:10.1038/ncb996
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brief communication
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Yong Zhang, Xinsheng Gao, Leslie J. Saucedo, Binggen Ru, Bruce A. Edgar and Duojia Pan
Nature Cell Biology 5, 578–581
(June 2003); doi:10.1038/ncb999
| First Paragraph | Full Text (HTML/PDF) |

article
NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway
Daniel D Billadeau, Jadee L Upshaw, Renee A Schoon, Christopher J Dick and Paul J Leibson
Nature Immunology 4, 557–564
(June 2003); doi:10.1038/ni929
| Abstract | Full Text (HTML/PDF) |

article
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
Simona Zompi, Jessica A Hamerman, Kouetsu Ogasawara, Edina Schweighoffer, Victor L J Tybulewicz, James P Di Santo, Lewis L Lanier and Francesco Colucci
Nature Immunology 4, 565–572
(June 2003); doi:10.1038/ni930
| Abstract | Full Text (HTML/PDF) |

news and views
The choices of a natural killer
Giorgio Trinchieri
Nature Immunology 4, 509–510
(June 2003); doi:10.1038/ni0603-509
| Full Text (HTML/PDF) |

article
Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
Lixin Rui, Carola G Vinuesa, Julie Blasioli and Christopher C Goodnow
Nature Immunology 4, 594–600
(June 2003); doi:10.1038/ni924
| Abstract | Full Text (HTML/PDF) |

review article
The biology of VEGF and its receptors
Napoleone Ferrara, Hans-Peter Gerber and Jennifer LeCouter
Nature Medicine 9, 669–676
(June 2003); doi:10.1038/nm0603-669
| Abstract | Full Text (HTML/PDF) |

brief communication
Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation
Darrin H Brager, Xiang Cai and Scott M Thompson
Nature Neuroscience 6, 551–552
(June 2003); doi:10.1038/nn1067
| First Paragraph | Full Text (HTML/PDF) |

letters to nature
Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
Yumi Yamamoto, Udit N. Verma, Shashi Prajapati, Youn-Tae Kwak and Richard B. Gaynor
Nature 423, 655–659
(05 June 2003); doi:10.1038/nature01576
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
Vasiliki Anest, Julie L. Hanson, Patricia C. Cogswell, Kris A. Steinbrecher, Brian D. Strahl and Albert S. Baldwin
Nature 423, 659–663
(05 June 2003); doi:10.1038/nature01648
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news and views
Signal transduction: A regulator branches out
Alain Israël
Nature 423, 596–597
(05 June 2003); doi:10.1038/423596a
| Full Text (HTML / PDF) |

article
MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb
Yasuhiko Kawakami, Joaquín Rodríguez-León, Christopher M. Koth, Dirk Büscher, Tohru Itoh, Ángel Raya, Jennifer K. Ng, Concepción Rodríguez Esteban, Shigeru Takahashi, Domingos Henrique, May-Fun Schwarz, Hiroshi Asahara and Juan Carlos Izpisúa Belmonte
Nature Cell Biology 5, 513–519
(June 2003); doi:10.1038/ncb989
| Abstract | Full Text (HTML/PDF) |

news and views
Deconstructing phosphatases in limb development
Andrew T. Dudley and Clifford J. Tabin
Nature Cell Biology 5, 499–501
(June 2003); doi:10.1038/ncb0603-499
| Full Text (HTML/PDF) |

news and views
IKKα: a chromatin modifier
Sowmya Swaminathan
Nature Cell Biology 5, 503
(June 2003); doi:10.1038/ncb0603-503
| Full Text (HTML/PDF) |

review article
ROCKs: multifunctional kinases in cell behaviour
Kirsi Riento and Anne J. Ridley
Nature Reviews Molecular Cell Biology 4, 446–456
(June 2003); doi:10.1038/nrm1128
| Summary | Full Text (HTML / PDF) |

article
SOCS3 negatively regulates IL-6 signaling in vivo
Ben A Croker, Danielle L Krebs, Jian-Guo Zhang, Sam Wormald, Tracy A Willson, Edouard G Stanley, Lorraine Robb, Christopher J Greenhalgh, Irmgard Förster, Björn E Clausen, Nicos A Nicola, Donald Metcalf, Douglas J Hilton, Andrew W Roberts and Warren S Alexander
Nature Immunology 4, 540–545
(June 2003); doi:10.1038/ni931
| Abstract | Full Text (HTML/PDF) |

article
SOCS3 regulates the plasticity of gp130 signaling
Roland Lang, Anne-Laure Pauleau, Evan Parganas, Yutaka Takahashi, Jörg Mages, James N Ihle, Robert Rutschman and Peter J Murray
Nature Immunology 4, 546–550
(June 2003); doi:10.1038/ni932
| Abstract | Full Text (HTML/PDF) |

article
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Hideo Yasukawa, Masanobu Ohishi, Hiroyuki Mori, Masaaki Murakami, Takatoshi Chinen, Daisuke Aki, Toshikatsu Hanada, Kiyoshi Takeda, Shizuo Akira, Masahiko Hoshijima, Toshio Hirano, Kenneth R Chien and Akihiko Yoshimura
Nature Immunology 4, 551–556
(June 2003); doi:10.1038/ni938
| Abstract | Full Text (HTML/PDF) |

news and views
Matching SOCS with function
James A Johnston and John J O'Shea
Nature Immunology 4, 507–509
(June 2003); doi:10.1038/ni0603-507
| Full Text (HTML/PDF) |

article
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists
Naoto Hoshi, Jia-Sheng Zhang, Miho Omaki, Takahiro Takeuchi, Shigeru Yokoyama, Nicolas Wanaverbecq, Lorene K Langeberg, Yukio Yoneda, John D Scott, David A Brown and Haruhiro Higashida
Nature Neuroscience 6, 564–571
(June 2003); doi:10.1038/nn1062
| Abstract | Full Text (HTML/PDF) |

May

news and views
Cell division: Genome maintenance
Jordan W. Raff
Nature 423, 493–495
(29 May 2003); doi:10.1038/423493a
| Full Text (HTML / PDF) |

letter
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I
Rosemary K. Clyne, Vittorio L. Katis, Lea Jessop, Kirsten R. Benjamin, Ira Herskowitz, Michael Lichten and Kim Nasmyth
Nature Cell Biology 5, 480–485
(May 2003); doi:10.1038/ncb977
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news and views
Monopolar attachment by Polo
Yoshinori Watanabe
Nature Cell Biology 5, 379–382
(May 2003); doi:10.1038/ncb0503-379
| Full Text (HTML/PDF) |

news and views
Alzheimer's disease: Mental plaque removal
Bart De Strooper and James Woodgett
Nature 423, 392–393
(22 May 2003); doi:10.1038/423392a
| Full Text (HTML / PDF) |

letters to nature
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
Christopher J. Phiel, Christina A. Wilson, Virginia M.-Y. Lee and Peter S. Klein
Nature 423, 435–439
(22 May 2003); doi:10.1038/nature01640
| First Paragraph | Full Text (HTML / PDF) |

letter
Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
Ping Chen, Frederique Zindy, Caroline Abdala, Feng Liu, Xiankui Li, Martine F. Roussel and Neil Segil
Nature Cell Biology 5, 422–426
(May 2003); doi:10.1038/ncb976
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news and views
Deafening cycle
Bridget Baumgartner and J. Wade Harper
Nature Cell Biology 5, 385–387
(May 2003); doi:10.1038/ncb0503-385
| Full Text (HTML/PDF) |

review article
Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel and Sheldon Milstien
Nature Reviews Molecular Cell Biology 4, 397–407
(May 2003); doi:10.1038/nrm1103
| Summary | Full Text (HTML / PDF) |

review article
Caenorhabditis elegans: an emerging genetic model for the study of innate immunity
C. Léopold Kurz and Jonathan J. Ewbank
Nature Reviews Genetics 4, 380–390
(May 2003); doi:10.1038/nrg1067
| Summary | Full Text (HTML / PDF) |

article
Chk2 activates E2F-1 in response to DNA damage
Craig Stevens, Linda Smith and Nicholas B. La Thangue
Nature Cell Biology 5, 401–409
(May 2003); doi:10.1038/ncb974
| Abstract | Full Text (HTML/PDF) |

letter
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
Atsuo Sasaki, Takaharu Taketomi, Reiko Kato, Kazuko Saeki, Atsushi Nonami, Mika Sasaki, Masamitsu Kuriyama, Naoaki Saito, Masabumi Shibuya and Akihiko Yoshimura
Nature Cell Biology 5, 427–432
(May 2003); doi:10.1038/ncb978
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news and views
Split personalities: the agonistic antagonist Sprouty
Gerhard Christofori
Nature Cell Biology 5, 377–379
(May 2003); doi:10.1038/ncb0503-377
| Full Text (HTML/PDF) |

article
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
Marina Karaghiosoff, Ralf Steinborn, Pavel Kovarik, Gernot Kriegshäuser, Manuela Baccarini, Birgit Donabauer, Ursula Reichart, Thomas Kolbe, Christian Bogdan, Tomas Leanderson, David Levy, Thomas Decker and Mathias Müller
Nature Immunology 4, 471–477
(May 2003); doi:10.1038/ni910
| Abstract | Full Text (HTML/PDF) |

letter
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation
Andrew R. Reynolds, Christian Tischer, Peter J. Verveer, Oliver Rocks and Philippe I. H. Bastiaens
Nature Cell Biology 5, 447–453
(May 2003); doi:10.1038/ncb981
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letter
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
Kaisa Haglund, Sara Sigismund, Simona Polo, Iwona Szymkiewicz, Pier Paolo Di Fiore and Ivan Dikic
Nature Cell Biology 5, 461–466
(May 2003); doi:10.1038/ncb983
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article
IKK and TBK1 are essential components of the IRF3 signaling pathway
Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia, Daniel C. Rowe, Eicke Latz, Douglas T. Golenbock, Anthony J. Coyle, Sha-Mei Liao and Tom Maniatis
Nature Immunology 4, 491–496
(May 2003); doi:10.1038/ni921
| Abstract | Full Text (HTML/PDF) |

news and views
Linking Toll-like receptors to IFN-a/b expression
Gregory M. Barton and Ruslan Medzhitov
Nature Immunology 4, 432–433
(May 2003); doi:10.1038/ni0503-432
| Full Text (HTML/PDF) |

article
The two faces of IKK and NF-kB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
Lee-Wei Chen, Laurence Egan, Zhi-Wei Li, Florian R. Greten, Martin F. Kagnoff and Michael Karin
Nature Medicine 9, 575–581
(May 2003); doi:10.1038/nm849
| Abstract | Full Text (HTML/PDF) |

article
A PKC-ENH-channel complex specifically modulates N-type Ca²⁺ channels
Yuka Maeno-Hikichi, Shaohua Chang, Kiyoyuki Matsumura, Meizan Lai, Hong Lin, Noritaka Nakagawa, Shun'ichi Kuroda and Ji-fang Zhang
Nature Neuroscience 6, 468–475
(May 2003); doi:10.1038/nn1041
| Abstract | Full Text (HTML/PDF) |

original paper
v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1
A Maclaren, W Clark, E J Black, D Gregory, H Fujii and D A F Gillespie
Oncogene 22, 2383–2395
(May 2003); doi:10.1038/sj.onc.1206329
| Abstract | Full Text (HTML/PDF) |

April

news and views
Cancer: Escape from inhibition
Sara A. Courtneidge
Nature 422, 827–828
(24 April 2003); doi:10.1038/422827a
| Full Text (HTML / PDF) |

letter
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2
Joseph R. Pomerening, Eduardo D. Sontag, James E. Ferrell Jr
Nature Cell Biology 5, 346–351
(April 2003); doi:10.1038/ncb954
| First Paragraph | Full Text (HTML/PDF) |

letter
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan
Alo Ray, Ronald E. Hector, Nilanjan Roy, Jee-Hyeon Song, Kathleen L. Berkner and Kurt W. Runge
Nature Genetics 33, 522–526
(April 2003); doi:10.1038/ng1132
| First Paragraph | Full Text (HTML/PDF) |

review article
Issues and progress with protein kinase inhibitors for cancer treatment
Janet Dancey and Edward A. Sausville
Nature Reviews Drug Discovery 2, 296–313
(April 2003); doi:10.1038/nrd1066
| Summary | Full Text (HTML / PDF) |

original paper
Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways
Aura S. Kamiguti, Robert J. Harris, Joseph R. Slupsky, Peter K. Baker, John C. Cawley and Mirko Zuzel
Oncogene 22, 2272–2284
(17 April 2003); doi:10.1038/sj.onc.1206398
| Abstract | Full Text (HTML/PDF) |

article
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
Kazuhito Tomizawa, Norichika Iga, Yun-Fei Lu, Akiyoshi Moriwaki, Masayuki Matsushita, Sheng-Tian Li, Osamu Miyamoto, Toshifumi Itano and Hideki Matsui
Nature Neuroscience 6, 384–390
(April 2003); doi:10.1038/nn1023
| Abstract | Full Text (HTML/PDF) |

news and views
Got milk? Oxytocin triggers hippocampal plasticity
Douglas A. Monks, Joseph S. Lonstein and S. Marc Breedlove
Nature Neuroscience 6, 327–328
(April 2003); doi:10.1038/nn0403-327
| Full Text (HTML/PDF) |

original paper
Heregulin-β1 regulates the estrogen receptor-α gene expression and activity via the ErbB2/PI 3-K/Akt pathway
Gerald E Stoica, Thomas F Franke, Anton Wellstein, Elisha Morgan, Frank Czubayko, Heinz-Joachim List, Ronald Reiter, Mary Beth Martin and Adriana Stoica
Oncogene 22, 2073–2087
(10 April 2003); doi:10.1038/sj.onc.1206311
| Abstract |

article
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl
Pamela J. Plant, James P. Fawcett, Dan C.C. Lin, Amy D. Holdorf, Kathleen Binns, Sarang Kulkarni and Tony Pawson
Nature Cell Biology 5, 301–308
(April 2003); doi:10.1038/ncb948
| Abstract | Full Text (HTML/PDF) |

news and views
A lethal giant kinase in cell polarity
Nicholas J. Justice and Yuh Nung Jan
Nature Cell Biology 5, 273–274
(April 2003); doi:10.1038/ncb0403-273
| Full Text (HTML/PDF) |

article
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates
Hongyan Wang, Eun-Yi Moon, Abdallah Azouz, Xiang Wu, Andrew Smith, Helga Schneider, Nancy Hogg and Christopher E. Rudd
Nature Immunology 4, 366–374
(April 2003); doi:10.1038/ni913
| Abstract | Full Text (HTML/PDF) |

brief communication
Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCβ4 signaling
Donghyun Park, Sukchan Lee, Kisun Jun, Yeon-Mi Hong, Do Young Kim, Yang In Kim and Hee-Sup Shin
Nature Neuroscience 6, 337–338
(April 2003); doi:10.1038/nn1033
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article
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1
Rina Plattner, Brenda J. Irvin, Shuling Guo, Kevin Blackburn, Andrius Kazlauskas, Robert T. Abraham, John D. York and Ann Marie Pendergast
Nature Cell Biology 5, 309–319
(April 2003); doi:10.1038/ncb949
| Abstract | Full Text (HTML/PDF) |

letter
PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1
Johanna Ivaska, Lisardo Bosca and Peter J. Parker
Nature Cell Biology 5, 363–369
(April 2003); doi:10.1038/ncb957
| First Paragraph | Full Text (HTML/PDF) |

letter
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
Mark O'Driscoll, Victor L. Ruiz-Perez, C. Geoffrey Woods, Penny A. Jeggo and Judith A. Goodship
Nature Genetics 33, 497–501
(April 2003); doi:10.1038/ng1129
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brief communication
EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing
Anna Aurora Battaglia, Karina Sehayek, John Grist, Stephen B. McMahon and Isabella Gavazzi
Nature Neuroscience 6, 339–340
(April 2003); doi:10.1038/nn1034
| First Paragraph | Full Text (HTML/PDF) |

original paper
MAP kinase activation by interleukin-9 in lymphoid and mast cell lines
Jean-Baptiste Demoulin, Jamila Louahed, Laure Dumoutier, Monique Stevens and Jean-Christophe Renauld
Oncogene 22, 1763–1770
(27 March 2003); doi:10.1038/sj.onc.1206253
| Abstract |

March

article
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W. Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki and Shigeo Koyasu
Nature Immunology 4, 280–286
(March 2003); doi:10.1038/ni890
| Abstract | Full Text (HTML/PDF) |

article
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Michael D. Ehlers
Nature Neuroscience 6, 231–242
(March 2003); doi:10.1038/nn1013
| Abstract | Full Text (HTML/PDF) |

article
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex
Gianluca Canettieri, Ianessa Morantte, Ernesto Guzmán, Hiroshi Asahara, Stephan Herzig, Scott D. Anderson, John R. Yates and III Marc Montminy
Nature Structural Biology 10, 175–181
(March 2003); doi:10.1038/nsb895
| Abstract | Full Text (HTML/PDF) |

news and views
The decline of induced transcription: a case of enzymatic symbiosis
Paolo Sassone-Corsi
Nature Structural Biology 10, 151–152
(March 2003); doi:10.1038/nsb0303-151
| Full Text (HTML/PDF) |

article
Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca²⁺-calmodulin
Emiko Yamauchi, Toru Nakatsu, Mamoru Matsubara, Hiroaki Kato and Hisaaki Taniguchi
Nature Structural Biology 10, 226–231
(March 2003); doi:10.1038/nsb900
| Abstract | Full Text (HTML/PDF) |

news and views
Ready to partner
Mark X. Sliwkowski
Nature Structural Biology 10, 158–159
(March 2003); doi:10.1038/nsb0303-158
| Full Text (HTML/PDF) |

letters to nature
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
Jörg Betschinger, Karl Mechtler and Juergen A. Knoblich
Nature 422, 326–330
(20 March 2003); doi:10.1038/nature01486
| First Paragraph | Full Text (HTML / PDF) |

article
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase
Stéphane Gasman, Yannis Kalaidzidis and Marino Zerial
Nature Cell Biology 5, 195–204
(March 2003); doi:10.1038/ncb935
| Abstract | Full Text (HTML/PDF) |

letter
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
Claudia Lukas, Jacob Falck, Jirina Bartkova, Jiri Bartek and Jiri Lukas
Nature Cell Biology 5, 255–260
(March 2003); doi:10.1038/ncb945
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia
Guilherme Lucas, Panu Hendolin, Tibor Harkany, Karin Agerman, Gustavo Paratcha, Carl Holmgren, Yuri Zilberter, Mikko Sairanen, Liliana Minichiello, Eero Castren and Patrik Ernfors
Nature Neuroscience 6, 221–222
(March 2003); doi:10.1038/nn1021
| First Paragraph | Full Text (HTML/PDF) |

article
Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases
Tracy A. Young, Benedicte Delagoutte, James A. Endrizzi, Arnold M. Falick and Tom Alber
Nature Structural Biology 10, 168–174
(March 2003); doi:10.1038/nsb897
| Abstract | Full Text (HTML/PDF) |

brief communication
Translocation of CaM kinase II to synaptic sites in vivo
Michelle R. Gleason, Shin-ichi Higashijima, Julia Dallman, Katharine Liu, Gail Mandel and Joseph R. Fetcho
Nature Neuroscience 6, 217–218
(March 2003); doi:10.1038/nn1011
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letter
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
Ming-Ying Tsai, Christiane Wiese, Kan Cao, Ona Martin, Peter Donovan, Joan Ruderman, Claude Prigent and Yixian Zheng
Nature Cell Biology 5, 242–248
(March 2003); doi:10.1038/ncb936
| First Paragraph | Full Text (HTML/PDF) |

article
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Irena Štefanová, Bernhard Hemmer, Marco Vergelli, Roland Martin, William E. Biddison and Ronald N. Germain
Nature Immunology 4, 248–254
(March 2003); doi:10.1038/ni895
| Abstract | Full Text (HTML/PDF) |

news and views
Tuning the immune system: competing positive and negative feedback loops
Daniel L. Mueller
Nature Immunology 4, 210–211
(March 2003); doi:10.1038/ni0303-210
| Full Text (HTML/PDF) |

article
Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development
Kaoru Saijo, Christian Schmedt, I-hsin Su, Hajime Karasuyama, Clifford A. Lowell, Michael Reth, Takahiro Adachi, Alina Patke, Angela Santana and Alexander Tarakhovsky
Nature Immunology 4, 274–279
(March 2003); doi:10.1038/ni893
| Abstract | Full Text (HTML/PDF) |

article
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
Jie Fan and Asrar B. Malik
Nature Medicine 9, 315–321
(March 2003); doi:10.1038/nm832
| Abstract | Full Text (HTML/PDF) |

review article
ATM and related protein kinases: safeguarding genome integrity
Yosef Shiloh
Nature Reviews Cancer 3, 155–168
(March 2003); doi:10.1038/nrc1011
| Summary | Full Text (HTML / PDF) |

article
A role for CK2 in the Drosophila circadian oscillator
Bikem Akten, Eike Jauch, Ginka K. Genova, Eun Young Kim, Isaac Edery, Thomas Raabe and F. Rob Jackson
Nature Neuroscience 6, 251–257
(March 2003); doi:10.1038/nn1007
| Abstract | Full Text (HTML/PDF) |

news and views
A new role for an old kinase: CK2 and the circadian clock
Justin Blau
Nature Neuroscience 6, 208–210
(March 2003); doi:10.1038/nn0303-208
| Full Text (HTML/PDF) |

February

letter
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
Mark Jackman, Catherine Lindon, Erich A. Nigg and Jonathon Pines
Nature Cell Biology 5, 143–148
(February 2003); doi:10.1038/ncb918
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letter
SAP couples Fyn to SLAM immune receptors
Betty Chan, Arpad Lanyi, Hyun Kyu Song, Jan Griesbach, Maria Simarro-Grande, Florence Poy, Duncan Howie, Janos Sumegi, Cox Terhorst and Michael J. Eck
Nature Cell Biology 5, 155–160
(February 2003); doi:10.1038/ncb920
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article
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
Claudine Irles, Antony Symons, Frédérique Michel, Talitha R. Bakker, P. Anton van der Merwe and Oreste Acuto
Nature Immunology 4, 189–197
(February 2003); doi:10.1038/ni877
| Abstract | Full Text (HTML/PDF) |

brief communication
The eye is necessary for a circadian rhythm in the suprachiasmatic nucleus
Han S. Lee, Jennifer L. Nelms, Mary Nguyen, Rae Silver and Michael N. Lehman
Nature Neuroscience 6, 111–112
(February 2003); doi:10.1038/nn1006
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news and views
The master clock becomes a servant
Brian Fiske
Nature Neuroscience 6, 108
(February 2003); doi:10.1038/nn0203-108
| Full Text (HTML/PDF) |

letter
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
Toby W. Hurd, Lin Gao, Michael H. Roh, Ian G. Macara and Ben Margolis
Nature Cell Biology 5, 137–142
(February 2003); doi:10.1038/ncb923
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letter
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
Akiko Kumagai and William G. Dunphy
Nature Cell Biology 5, 161–165
(February 2003); doi:10.1038/ncb921
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letters to nature
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Sandrine Etienne-Manneville and Alan Hall
Nature 421, 753–756
(13 February 2003); doi:10.1038/nature01423
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letters to nature
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
Hyun-Soo Cho, Karen Mason, Kasra X. Ramyar, Ann Marie Stanley, Sandra B. Gabelli, Dan W. Denney Jr and Daniel J. Leahy
Nature 421, 756–760
(13 February 2003); doi:10.1038/nature01392
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article
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
Leo E. Otterbein, Brian S. Zuckerbraun, Manabu Haga, Fang Liu, Ruiping Song, Anny Usheva, Christina Stachulak, Natalya Bodyak, R. Neal Smith, Eva Csizmadia, Shivraj Tyagi, Yorihiro Akamatsu, Richard J. Flavell, Timothy R. Billiar, Edith Tzeng, Fritz H. Bach, Augustine M.K. Choi and Miguel P. Soares
Nature Medicine 9, 183–190
(February 2003); doi:10.1038/nm817
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review article
Coordinated regulation of life and death by RB
B. Nelson Chau and Jean Y.J. Wang
Nature Reviews Cancer 3, 130–138
(February 2003); doi:10.1038/nrc993
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article
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Keith K. Murai, Louis N. Nguyen, Fumitoshi Irie, Yu Yamaguchi and Elena B. Pasquale
Nature Neuroscience 6, 153–160
(February 2003); doi:10.1038/nn994
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news and views
Ephrins keep dendritic spines in shape
Scott M. Thompson
Nature Neuroscience 6, 103–104
(February 2003); doi:10.1038/nn0203-103
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letters to nature
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
Kwok-Kin Wong, Richard S. Maser, Robert M. Bachoo, Jayant Menon, Daniel R. Carrasco, Yansong Gu, Frederick W. Alt and Ronald A. DePinho
Nature 421, 643–648
(06 February 2003); doi:10.1038/nature01385
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article
Fas engagement induces neurite growth through ERK activation and p35 upregulation
Julie Desbarats, Raymond B. Birge, Manuelle Mimouni-Rongy, David E. Weinstein, Jean-Sébastien Palerme and M. Karen Newell
Nature Cell Biology 5, 118–125
(February 2003); doi:10.1038/ncb916
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news and views
Killer wiles: growing interest in Fas
Brigitte Pettmann and Christopher E. Henderson
Nature Cell Biology 5, 91–92
(February 2003); doi:10.1038/ncb0203-91
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letter
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation
Sylvain Latour, Romain Roncagalli, Riyan Chen, Marcin Bakinowski, Xiaochu Shi, Pamela L. Schwartzberg, Dominique Davidson and André Veillette
Nature Cell Biology 5, 149–154
(February 2003); doi:10.1038/ncb919
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review article
Tor signalling in bugs, brain and brawn
Estela Jacinto and Michael N. Hall
Nature Reviews Molecular Cell Biology 4, 117–126
(February 2003); doi:10.1038/nrm1018
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news and views
Splitting vessels: Keeping lymph apart from blood
Shahin Rafii and Mihaela Skobe
Nature Medicine 9, 166–168
(February 2003); doi:10.1038/nm0203-166
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article
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
José A. Esteban, Song-Hai Shi, Christopher Wilson, Mutsuo Nuriya, Richard L. Huganir and Roberto Malinow
Nature Neuroscience 6, 136–143
(February 2003); doi:10.1038/nn997
| Abstract | Full Text (HTML/PDF) |

original paper
Bcl-x_L and Akt cooperate to promote leukemogenesis in vivo
Robyn Karnauskas, Qun Niu, Sunit Talapatra, David R. Plas, Marianne E. Greene, John D. Crispino and Charles M. Rudin
Oncogene 22, 688–698
(6 February 2003); doi:10.1038/sj.onc.1206159
| Abstract |

January

article
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Christopher J. Bakkenist and Michael B. Kastan
Nature 421, 499–506
(30 January 2003); doi:10.1038/nature01368
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news and views
DNA repair: Damage alert
Jiri Bartek and Jiri Lukas
Nature 421, 486–488
(30 January 2003); doi:10.1038/421486a
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letters to nature
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
Sophie G. Martin and Daniel St Johnston
Nature 421, 379–384
(23 January 2003); doi:10.1038/nature01296
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letter
The mismatch repair system is required for S-phase checkpoint activation
Kevin D. Brown, Abhilasha Rathi, Ravindra Kamath, Dillon I. Beardsley, Qimin Zhan, Jennifer L. Mannino and R Baskaran
Nature Genetics 33, 80–84
(January 2003); doi:10.1038/ng1052
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article
IL-28, IL-29 and their class II cytokine receptor IL-28R
Paul Sheppard, Wayne Kindsvogel, Wenfeng Xu, Katherine Henderson, Stacy Schlutsmeyer, Theodore E. Whitmore, Rolf Kuestner, Ursula Garrigues, Carl Birks, Jenny Roraback, Craig Ostrander, Dennis Dong, Jinu Shin, Scott Presnell, Brian Fox, Betty Haldeman, Emily Cooper, David Taft, Teresa Gilbert, Francis J. Grant, Monica Tackett, William Krivan, Gary McKnight, Chris Clegg, Don Foster and Kevin M. Klucher
Nature Immunology 4, 63–68
(January 2003); doi:10.1038/ni873
| Abstract | Full Text (HTML/PDF) |

article
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Sergei V. Kotenko, Grant Gallagher, Vitaliy V. Baurin, Anita Lewis-Antes, Meiling Shen, Nital K. Shah, Jerome A. Langer, Faruk Sheikh, Harold Dickensheets and Raymond P. Donnelly
Nature Immunology 4, 69–77
(January 2003); doi:10.1038/ni875
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news and views
Novel interferons
Jan Vilcek
Nature Immunology 4, 8–9
(January 2003); doi:10.1038/ni0103-8
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article
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
Samuel Davis, Nick Papadopoulos, Thomas H. Aldrich, Peter C. Maisonpierre, Tammy Huang, Lubomir Kovac, April Xu, Raymond Leidich, Elzbieta Radziejewska, Ashique Rafique, Judah Goldberg, Vivek Jain, Kevin Bailey, Margaret Karow, Jim Fandl, Steven J. Samuelsson, Ella Ioffe, John S. Rudge, Thomas J. Daly, Czeslaw Radziejewski and George D. Yancopoulos
Nature Structural Biology 10, 38–44
(January 2003); doi:10.1038/nsb880
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letters to nature
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Martin Holzenberger, Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C. Even, Pascale Cervera and Yves Le Bouc
Nature 421, 182–187
(09 January 2003); doi:10.1038/nature01298
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news and views
Physiology: Cost-free longevity in mice?
Gordon J. Lithgow and Matthew S. Gill
Nature 421, 125–126
(09 January 2003); doi:10.1038/421125a
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letters to nature
Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12
Chris Nelson, Susan Goto, Karen Lund, Wesley Hung and Ivan Sadowski
Nature 421, 187–190
(09 January 2003); doi:10.1038/nature01243
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review article
Nongenomic actions of steroid hormones
Ralf Lösel and Martin Wehling
Nature Reviews Molecular Cell Biology 4, 46–55
(January 2003); doi:10.1038/nrm1009
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article
Tyrosine phosphorylation of VHR phosphatase by ZAP-70
Andres Alonso, Souad Rahmouni, Scott Williams, Marianne van Stipdonk, Lukasz Jaroszewski, Adam Godzik, Robert T. Abraham, Stephen P. Schoenberger and Tomas Mustelin
Nature Immunology 4, 44–48
(January 2003); doi:10.1038/ni856
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news and views
ZAP-ping T-cell activation
Sarah Greaves
Nature Cell Biology 5, 13
(January 2003); doi:10.1038/ncb0103-13
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article
Melusin, a muscle-specific integrin β₁-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
Mara Brancaccio, Luigi Fratta, Antonella Notte, Emilio Hirsch, Roberta Poulet, Simona Guazzone, Marika De Acetis, Carmine Vecchione, Gennaro Marino, Fiorella Altruda, Lorenzo Silengo, Guido Tarone and Giuseppe Lembo
Nature Medicine 9, 68–75
(January 2003); doi:10.1038/nm805
| Abstract | Full Text (HTML/PDF) |

news and views
Sensing heart stress
Liza Barki-Harrington and Howard A. Rockman
Nature Medicine 9, 19–20
(January 2003); doi:10.1038/nm0103-19
| Full Text (HTML/PDF) |

review article
The Fanconi anaemia/BRCA pathway
Alan D. D'Andrea and Markus Grompe
Nature Reviews Cancer 3, 23–34
(January 2003); doi:10.1038/nrc970
| Summary | Full Text (HTML / PDF) |

article
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Siu Sylvia Lee, Raymond Y.N. Lee, Andrew G. Fraser, Ravi S. Kamath, Julie Ahringer and Gary Ruvkun
Nature Genetics 33, 40–48
(January 2003); doi:10.1038/ng1056
| Abstract | Full Text (HTML/PDF) |

article
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling
Surojit Paul, Angus C. Nairn, Ping Wang and Paul J. Lombroso
Nature Neuroscience 6, 34–42
(January 2003); doi:10.1038/nn989
| Abstract | Full Text (HTML/PDF) |

article
A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines
Stefan A. Muljo and Mark S. Schlissel
Nature Immunology 4, 31–37
(January 2003); doi:10.1038/ni870
| Abstract | Full Text (HTML/PDF) |

article
The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion
Alexandra Flemming, Tilman Brummer, Michael Reth and Hassan Jumaa
Nature Immunology 4, 38–43
(January 2003); doi:10.1038/ni862
| Abstract | Full Text (HTML/PDF) |

news and views
Checks and balances on developing B cells
Tomohiro Kurosaki
Nature Immunology 4, 13–15
(January 2003); doi:10.1038/ni0103-13
| Full Text (HTML/PDF) |

review article
Metastasis suppressors alter the signal transduction of cancer cells
Patricia S. Steeg
Nature Reviews Cancer 3, 55–63
(January 2003); doi:10.1038/nrc967
| Summary | Full Text (HTML / PDF) |

brief communication
A developmental switch in the signaling cascades for LTP induction
Hiroki Yasuda, Alison L. Barth, David Stellwagen and Robert C. Malenka
Nature Neuroscience 6, 15–16
(January 2003); doi:10.1038/nn985
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