article Genome-wide survey of protein kinases required for cell cycle progression
M. Bettencourt-Dias, R. Giet, R. Sinka, A. Mazumdar, W. G. Lock, F. Balloux, P. J. Zafiropoulos, S. Yamaguchi, S. Winter, R. W. Carthew, M. Cooper, D. Jones, L. Frenz and D. M. Glover Nature432, 980–987
(23 December 2004); doi:10.1038/nature03160
| Abstract | Full Text (HTML / PDF) |
letters to nature Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang Nature432, 1045–1050
(23 December 2004); doi:10.1038/nature03179
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letter Adiponectin-mediated modulation of hypertrophic signals in the heart
Rei Shibata, Noriyuki Ouchi, Masahiro Ito, Shinji Kihara, Ichiro Shiojima, David R Pimentel, Masahiro Kumada, Kaori Sato, Stephan Schiekofer, Koji Ohashi, Tohru Funahashi, Wilson S Colucci and Kenneth Walsh Nature Medicine10, 1384–1389
(December 2004); doi:10.1038/nm1137
| First Paragraph | Full Text (HTML/PDF) |
technical report Protein microarrays for multiplex analysis of signal transduction pathways
Steven M Chan, Joerg Ermann, Leon Su, C Garrison Fathman and Paul J Utz Nature Medicine10, 1390–1396
(December 2004); doi:10.1038/nm1139
| Abstract | Full Text (HTML/PDF) |
review article Regulation of the cytoskeleton: an oncogenic function for cdk inhibitors?
Arnaud Besson, Richard K. Assoian and James M. Roberts Nature Reviews Cancer4, 948–955
(December 2004); doi:10.1038/nrc1501
| Abstract | Full Text (HTML / PDF) |
article Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
E S Anton, H T Ghashghaei, Janet L Weber, Corey McCann, Tobias M Fischer, Isla D Cheung, Martin Gassmann, Albee Messing, Rudiger Klein, Markus H Schwab, K C Kent Lloyd and Cary Lai Nature Neuroscience7, 1319–1328
(December 2004); doi:10.1038/nn1345
| Abstract | Full Text (HTML/PDF) |
review article Biochemical mechanisms for translational regulation in synaptic plasticity
Eric Klann and Thomas E. Dever Nature Reviews Neuroscience5, 931–942
(December 2004); doi:10.1038/nrn1557
| Abstract | Full Text (HTML / PDF) |
review article Strategies to overcome resistance to targeted protein kinase inhibitors
Henrik Daub, Katja Specht and Axel Ullrich Nature Reviews Drug Discovery3, 1001–1010
(December 2004); doi:10.1038/nrd1579
| Abstract | Full Text (HTML / PDF) |
article Scaffolding by ERK3 regulates MK5 in development
Stefanie Schumacher, Kathrin Laaß, Shashi Kant, Yu Shi, Axel Visel, Achim D Gruber, Alexey Kotlyarov and Matthias Gaestel EMBO Journal23, 4770–4779
(December 2004); doi:10.1038/sj.emboj.7600467
| Abstract | Full Text (HTML/PDF) |
article Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
Ole-Morten Seternes, Theresa Mikalsen, Bjarne Johansen, Espen Michaelsen, Chris G Armstrong, Nick A Morrice, Benjamin Turgeon, Sylvain Meloche, Ugo Moens and Stephen M Keyse EMBO Journal23, 4780–4791
(December 2004); doi:10.1038/sj.emboj.7600489
| Abstract | Full Text (HTML/PDF) |
letters to nature Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Ryosuke Tsunematsu, Keiichi I. Nakayama, Ken Brown, Sheila Bryson and Allan Balmain Nature432, 775–779
(09 December 2004); doi:10.1038/nature03155
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news and views PINOID pinpoints auxin
Myrto Raftopoulou Nature Cell Biology6, 1149
(December 2004); doi:10.1038/ncb1204-1149
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review article Meiosis: cell-cycle controls shuffle and deal
Adèle L. Marston and Angelika Amon Nature Reviews Molecular Cell Biology5, 983–997
(December 2004); doi:10.1038/nrm1526
| Abstract | Full Text (HTML / PDF) |
review article Viral hijacking of G-protein-coupled-receptor signalling networks
Akrit Sodhi, Silvia Montaner and J. Silvio Gutkind Nature Reviews Molecular Cell Biology5, 998–1012
(December 2004); doi:10.1038/nrm1529
| Abstract | Full Text (HTML / PDF) |
article Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
Weijia Kong, Jing Wei, Parveen Abidi, Meihong Lin, Satoru Inaba, Cong Li, Yanling Wang, Zizheng Wang, Shuyi Si, Huaining Pan, Shukui Wang, Jingdan Wu, Yue Wang, Zhuorong Li, Jingwen Liu and Jian-Dong Jiang Nature Medicine10, 1344–1351
(December 2004); doi:10.1038/nm1135
| Abstract | Full Text (HTML/PDF) |
review article Aurora-kinase inhibitors as anticancer agents
Nicholas Keen and Stephen Taylor Nature Reviews Cancer4, 927–936
(December 2004); doi:10.1038/nrc1502
| Abstract | Full Text (HTML / PDF) |
review article Targeting the mitogen-activated protein kinase cascade to treat cancer
Judith S. Sebolt-Leopold and Roman Herrera Nature Reviews Cancer4, 937–947
(December 2004); doi:10.1038/nrc1503
| Abstract | Full Text (HTML / PDF) |
brief communication Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
Fatma Simsek-Duran, David J Linden and György Lonart Nature Neuroscience7, 1296–1298
(December 2004); doi:10.1038/nn1348
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article Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
Jeffrey F Ohren, Huifen Chen, Alexander Pavlovsky, Christopher Whitehead, Erli Zhang, Peter Kuffa, Chunhong Yan, Patrick McConnell, Cindy Spessard, Craig Banotai, W Thomas Mueller, Amy Delaney, Charles Omer, Judith Sebolt-Leopold, David T Dudley, Iris K Leung, Cathlin Flamme, Joseph Warmus, Michael Kaufman, Stephen Barrett, Haile Tecle and Charles A Hasemann Nature Structural and Molecular Biology11, 1192–1197
(December 2004); doi:10.1038/nsmb859
| Abstract | Full Text (HTML/PDF) |
article Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas
Akira Watahiki, Kazunori Waki, Norihito Hayatsu, Toshiyuki Shiraki, Shinji Kondo, Mari Nakamura, Daisuke Sasaki, Takahiro Arakawa, Jun Kawai, Matthias Harbers, Yoshihide Hayashizaki1 and Piero Carninci Nature Methods1, 233–239
(December 2004); doi:10.1038/nmeth719
| Abstract | Full Text (HTML/PDF) |
review article AKAP signalling complexes: focal points in space and time
Wei Wong and John D. Scott Nature Reviews Molecular Cell Biology5, 959–970
(December 2004); doi:10.1038/nrm1527
| Summary | Full Text (HTML / PDF) |
article Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier
Fuan Wang, Yiyue Ma, John W Barrett, Xiujuan Gao, Joy Loh, Erik Barton, Herbert W Virgin and IV Grant McFadden Nature Immunology5, 1266–1274
(December 2004); doi:10.1038/ni1132
| Abstract | Full Text (HTML/PDF) |
news and views Why are rabbits uniquely sensitive to myxoma virus? Cherchez l'interferon! Jan Vilček
Nature Immunology5, 1205–1206
(December 2004); doi:10.1038/ni1204-1205
| Full Text (HTML/PDF) |
article Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice
Jing Zhang, Julie L Lefebvre, Shuxia Zhao & Michael Granato
Nature Neuroscience7, 1303–1309
(December 2004); doi:10.1038/nn1350
| Summary | Full Text (HTML / PDF) |
November
article Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Ildiko Bock-Marquette , Ankur Saxena , Michael D. White, J. Michael DiMaio and Deepak Srivastava Nature432, 466–472
(25 November 2004); doi:10.1038/nature03000
| Abstract | Full Text (HTML / PDF) |
news and views Regenerative medicine: Prometheus unbound
Michael D. Schneider Nature432, 451–453
(25 November 2004); doi:10.1038/432451a
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letters to nature A FADD-dependent innate immune mechanism in mammalian cells
Siddharth Balachandran, Emmanuel Thomas and Glen N. Barber Nature432, 401–405
(18 November 2004); doi:10.1038/nature03124
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brief communication A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
Giles S H Yeo, Chiao-Chien Connie Hung, Justin Rochford, Julia Keogh, Juliette Gray, Shoba Sivaramakrishnan, Stephen O'Rahilly and I Sadaf Farooqi Nature Neuroscience7, 1187–1189
(November 2004); doi:10.1038/nn1336
| First Paragraph | Full Text (HTML/PDF) |
letter Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A. Rüegg, Alan Hall and Michael N. Hall Nature Cell Biology6, 1122–1128
(November 2004); doi:10.1038/ncb1183
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review article The RAF proteins take centre stage
Claudia Wellbrock, Maria Karasarides and Richard Marais Nature Reviews Molecular Cell Biology5, 875–885
(November 2004); doi:10.1038/nrm1498
| Abstract | Full Text (HTML / PDF) |
article Focal adhesion kinase in netrin-1 signaling
Xiu-rong Ren, Guo-li Ming, Yi Xie, Yan Hong, Dong-mei Sun, Zhong-qiu Zhao, Zhu Feng, Qiang Wang, Sangwoo Shim, Zhou-feng Chen, Hong-jun Song, Lin Mei and Wen-cheng Xiong Nature Neuroscience7, 1204–1212
(November 2004); doi:10.1038/nn1330
| Abstract | Full Text (HTML/PDF) |
article Activation of FAK and Src are receptor-proximal events required for netrin signaling
Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, Jennifer Aurandt, Tang-Long Shen, Eric R Fearon, Jun-Lin Guan, Min Han, Yi Rao, Kyonsoo Hong and Kun-Liang Guan Nature Neuroscience7, 1213–1221
(November 2004); doi:10.1038/nn1329
| Abstract | Full Text (HTML/PDF) |
article Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
Guofa Liu, Hilary Beggs, Claudia Jürgensen, Hwan-Tae Park, Hao Tang, Jessica Gorski, Kevin R Jones, Louis F Reichardt, Jane Wu and Yi Rao Nature Neuroscience7, 1222–1232
(November 2004); doi:10.1038/nn1331
| Abstract | Full Text (HTML/PDF) |
brief communication Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
Andrzej Ptasznik, Yuji Nakata, Anna Kalota, Stephen G Emerson and Alan M. Gewirtz Nature Medicine10, 1187–1189
(November 2004); doi:10.1038/nm1127
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article Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
Saumendra N Sarkar, Kristi L Peters, Christopher P Elco, Shuji Sakamoto, Srabani Pal and Ganes C Sen Nature Structural and Molecular Biology11, 1060–1067
(November 2004); doi:10.1038/nsmb847
| Abstract | Full Text (HTML/PDF) |
news and views Another detour on the Toll road to the interferon antiviral response
John Hiscott Nature Structural and Molecular Biology11, 1028–1030
(November 2004); doi:10.1038/nsmb1104-1028
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news and views Opening the GAP
Michelle Montoya Nature Structural and Molecular Biology11, 1033
(November 2004); doi:10.1038/nsmb1104-1033
| Full Text (HTML/PDF) |
October
letters to nature Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
Satoru Mimura, Takashi Seki, Seiji Tanaka and John F. X. Diffley Nature431, 1118–1123
(28 October 2004); doi:10.1038/nature03024
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article Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
Magnus Wolf-Watz, Vu Thai, Katherine Henzler-Wildman, Georgia Hadjipavlou, Elan Z Eisenmesser and Dorothee Kern Nature Structural and Molecular Biology11, 945–949
(October 2004); doi:10.1038/nsmb821
| Abstract | Full Text (HTML/PDF) |
news and views Out of hot water
Mikael Akke Nature Structural and Molecular Biology11, 912–913
(October 2004); doi:10.1038/nsmb1004-912
| Full Text (HTML/PDF) |
letters to nature Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan and Bart Vanhaesebroeck Nature431, 1007–1011
(21 October 2004); doi:10.1038/nature02991
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letters to nature DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
Grzegorz Ira, Achille Pellicioli, Alitukiriza Balijja, Xuan Wang, Simona Fiorani, Walter Carotenuto, Giordano Liberi, Debra Bressan, Lihong Wan, Nancy M. Hollingsworth, James E. Haber and Marco Foiani Nature431, 1011–1017
(21 October 2004); doi:10.1038/nature02964
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article Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
Binhua P. Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M. Li, Mehmet Gunduz and Mien-Chie Hung Nature Cell Biology6, 931–940
(October 2004); doi:10.1038/ncb1173
| Abstract | Full Text (HTML/PDF) |
news and views GSK-3β sets Snail's pace
Karni Schlessinger and Alan Hall Nature Cell Biology6, 913–915
(October 2004); doi:10.1038/ncb1004-913
| Full Text (HTML/PDF) |
brief communication A rapid method for determining protein kinase phosphorylation specificity
Jessica E Hutti, Emily T Jarrell, James D Chang, Derek W Abbott, Peter Storz, Alex Toker, Lewis C Cantley and Benjamin E Turk Nature Methods1, 27–29
(October 2004); doi:10.1038/nmeth708
| Abstract | Full Text (HTML/PDF) |
news and views Novel at the library
Michael B Yaffe Nature Methods1, 13–14
(October 2004); doi:10.1038/nmeth1004-13
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letter Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1
Xavier Escoté, Meritxell Zapater, Josep Clotet and Francesc Posas Nature Cell Biology6, 997–1002
(October 2004); doi:10.1038/ncb1174
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letter Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Dan Kawamori, Taka-aki Matsuoka, Munehide Matsuhisa, Yoshitaka Kajimoto, Hidenori Ichijo, Yoshimitsu Yamasaki and Masatsugu Hori Nature Medicine10, 1128–1132
(October 2004); doi:10.1038/nm1111
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letter Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
C. Graux, J. Cools, C. Melotte, H. Quentmeier, A. Ferrando, R. Levine, J.R. Vermeesch, M. Stul, B. Dutta, N. Boeckx, A. Bosly, P. Heimann, A. Uyttebroeck, N. Mentens, R. Somers, R.A.F. MacLeod, H.G. Drexler, A.T. Look, D.G. Gilliland, L. Michaux, P. Vandenberghe, I. Wlodarska, Peter Marynen and Anne Hagemeijer Nature Genetics36, 1084–1089
(October 2004); doi:10.1038/ng1425
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article A phenylalanine zipper mediates APS dimerization
Sirano Dhe-Paganon, Eric D Werner, Masahiro Nishi, Lone Hansen, Young-In Chi and Steven E Shoelson Nature Structural and Molecular Biology11, 968–974
(October 2004); doi:10.1038/nsmb829
| Abstract | Full Text (HTML/PDF) |
article A new effector pathway links ATM kinase with the DNA damage response
Constantinos Demonacos, Marija Krstic-Demonacos, Linda Smith, Danmei Xu, Darran P. O'Connor, Martin Jansson and Nicholas B. La Thangue Nature Cell Biology6, 968–976
(October 2004); doi:10.1038/ncb1170
| Abstract | Full Text (HTML/PDF) |
news and views Nutrient sensor links obesity with diabetes risk
Mary-Elizabeth Patti and Barbara B Kahn Nature Medicine10, 1049–1050
(October 2004); doi:10.1038/nm1004-1049
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article Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
Jayati Sengupta, Jakob Nilsson, Richard Gursky, Christian M T Spahn, Poul Nissen and Joachim Frank Nature Structural and Molecular Biology11, 957–962
(October 2004); doi:10.1038/nsmb822
| Abstract | Full Text (HTML/PDF) |
brief communication Lung cancer: Intragenic ERBB2 kinase mutations in tumours
Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S. Cooper, Adrienne M. Flanagan, Margaret Knowles, Suet Y. Leung, David N. Louis, Leendert H. J. Looijenga, Bruce Malkowicz, Marco A. Pierotti, Bin Teh, Georgia Chenevix-Trench, Barbara L. Weber, Siu T. Yuen, Grace Harris, Peter Goldstraw, Andrew G. Nicholson, P. Andrew Futreal, Richard Wooster and Michael R. Stratton Nature431, 525–526
(30 September 2004); doi:10.1038/431525b
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review article Integrin signalling during tumour progression
Wenjun Guo and Filippo G. Giancotti Nature Reviews Molecular Cell Biology5, 816–826
(October 2004); doi:10.1038/nrm1490
| Abstract | Full Text (HTML / PDF) |
article Control of axonal branching and synapse formation by focal adhesion kinase
Beatriz Rico, Hilary E Beggs, Dorreyah Schahin-Reed, Nikole Kimes, Andrea Schmidt and Louis F Reichardt Nature Neuroscience7, 1059–1069
(October 2004); doi:10.1038/nn1317
| Abstract | Full Text (HTML/PDF) |
review article PDZ domain proteins of synapses
Eunjoon Kim and Morgan Sheng Nature Reviews Neuroscience5, 771–781
(October 2004); doi:10.1038/nrn1517
| Abstract | Full Text (HTML / PDF) |
September
letters to nature Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling
Ingrid Mecklenbräuker, Susan L. Kalled, Michael Leitges, Fabienne Mackay and Alexander Tarakhovsky Nature431, 456–461
(23 September 2004); doi:10.1038/nature02955
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letter Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Alwin Krämer, Niels Mailand, Claudia Lukas, Randi G. Syljuåsen, Christopher J. Wilkinson, Erich A. Nigg, Jiri Bartek and Jiri Lukas Nature Cell Biology6, 884–891
(September 2004); doi:10.1038/ncb1165
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review article The SCF ubiquitin ligase: insights into a molecular machine
Timothy Cardozo and Michele Pagano Nature Reviews Molecular Cell Biology5, 739–751
(September 2004); doi:10.1038/nrm1471
| Abstract | Full Text (HTML / PDF) |
news and views From mRNA to tumor suppressor
Dan Mercola and John Welsh Nature Genetics36, 937–938
(September 2004); doi:10.1038/ng0904-937
| Full Text (HTML/PDF) |
article Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae
Masaya Suzuki, Ryoji Igarashi, Mizuho Sekiya, Takahiko Utsugi, Shinichi Morishita, Masashi Yukawa and Yoshikazu Ohya Nature Cell Biology6, 861–871
(September 2004); doi:10.1038/ncb1162
| Abstract | Full Text (HTML/PDF) |
news and views A new checkpoint takes shape
M. Andrew Hoyt Nature Cell Biology6, 801–803
(September 2004); doi:10.1038/ncb0904-801
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article Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton
Anjon Audhya, Robbie Loewith, Ainslie B Parsons, Lu Gao, Mitsuaki Tabuchi1, Huilin Zhou, Charles Boone, Michael N Hall and Scott D Emr The EMBO Journal Advanced Online Publication
(September 2004); doi:10.1038/sj.emboj.7600384
| Abstract | Full Text (HTML/PDF) |
letters to nature Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas Nature431, 200–205
(09 September 2004); doi:10.1038/nature02866
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review article Cell signalling and the control of pre-mRNA splicing
Chanseok Shin and James L. Manley Nature Reviews Molecular Cell Biology5, 727–738
(September 2004); doi:10.1038/nrm1467
| Abstract | Full Text (HTML / PDF) |
article PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
Bin Liu, Sheldon Mink, Kelly A Wong, Natalie Stein, Crescent Getman, Paul W Dempsey, Hong Wu and Ke Shuai Nature Immunology5, 891–898
(September 2004); doi:10.1038/ni1104
| Abstract | Full Text (HTML/PDF) |
news and views A peek at PIAS
John J O'Shea and Wendy Watford Nature Immunology5, 875–876
(September 2004); doi:10.1038/ni0904-875
| Full Text (HTML/PDF) |
letter CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
Jill R Crittenden, Wolfgang Bergmeier, Yanyu Zhang, Crystal L Piffath, Yuqiong Liang, Denisa D Wagner, David E Housman and Ann M Graybiel Nature Medicine10, 982–986
(September 2004); doi:10.1038/nm1098
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article Effects of G-protein mutations on skin color
Catherine D Van Raamsdonk, Karen R Fitch, Helmut Fuchs, Martin Hrabé de Angelis and Gregory S Barsh Nature Genetics36, 961–968
(September 2004); doi:10.1038/ng1412
| Abstract | Full Text (HTML/PDF) |
news and views The G-netics of dark skin
Ian J Jackson Nature Genetics36, 935–936
(September 2004); doi:10.1038/ng0904-935
| Full Text (HTML/PDF) |
news and views Unravelling Ras signals in cardiovascular disease
Kenneth R. Chien and Masahiko Hoshijima Nature Cell Biology6, 807–808
(September 2004); doi:10.1038/ncb0904–807
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perspectives Opinion: Switching on kinases: oncogenic activation of BRAF and the PDGFR family
Nick J. Dibb, Stephen M. Dilworth and Clifford D. Mol Nature Reviews Cancer4, 718–727
(September 2004); doi:10.1038/nrc1434
| Summary | Full Text (HTML / PDF) |
letter Nonsense–mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
Pia Huusko, Damaris Ponciano–Jackson, Maija Wolf, Jeff A Kiefer, David O Azorsa, Sukru Tuzmen, Don Weaver, Christiane Robbins, Tracy Moses, Minna Allinen, Sampsa Hautaniemi, Yidong Chen, Abdel Elkahloun, Mark Basik, G Steven Bova, Lukas Bubendorf, Alessandro Lugli, Guido Sauter, Johanna Schleutker, Hilmi Ozcelik, Sabine Elowe, Tony Pawson, Jeffrey M Trent, John D Carpten, Olli–P Kallioniemi and Spyro Mousses Nature Genetics36, 979–983
(September 2004); doi:10.1038/ng1408
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August
letters to nature Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
Sirith Douma, Theo van Laar, John Zevenhoven, Ralph Meuwissen, Evert van Garderen and Daniel S. Peeper Nature430, 1034–1039
(26 August 2004); doi:10.1038/nature02765
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news and views Anoikis: Cancer and the homeless cell
Lance A. Liotta and Elise Kohn Nature430, 973–974
(26 August 2004); doi:10.1038/430973a
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letters to nature Separase-mediated cleavage of cohesin at interphase is required for DNA repair
Koji Nagao, Yoh Adachi and Mitsuhiro Yanagida Nature430, 1044–1048
(26 August 2004); doi:10.1038/nature02803
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letter MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
Deborah N. Chadee and John M. Kyriakis Nature Cell Biology6, 770–776
(August 2004); doi:10.1038/ncb1152
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review article Protein kinase C and beyond
Martin Spitaler and Doreen A Cantrell Nature Immunology5, 785–790
(August 2004); doi:10.1038/ni1097
| Abstract | Full Text (HTML/PDF) |
letter Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation
Xinzhu Deng, E Randal Hofmann, Alberto Villanueva, Oliver Hobert, Paola Capodieci, Darren R Veach, Xianglei Yin, Luis Campodonico, Athanasios Glekas, Carlos Cordon-Cardo, Bayard Clarkson, William G Bornmann, Zvi Fuks, Michael O Hengartner and Richard Kolesnick Nature Genetics36, 906–912
(August 2004); doi:10.1038/ng1396
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research article Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function
Anhco Nguyen, Deborah M Rothman, Justine Stehn, Barbara Imperiali and Michael B Yaffe Nature Biotechnology22, 993–1000
(August 2004); doi:10.1038/nbt997
| Abstract | Full Text (HTML/PDF) |
letters to nature Cell cycle regulation of central spindle assembly
Masanori Mishima, Visnja Pavicic, Ulrike Grüneberg, Erich A. Nigg and Michael Glotzer Nature430, 908–913
(19 August 2004); doi:10.1038/nature02767
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news and views Cell division: Timing the machine
Bruce Bowerman Nature430, 840–842
(19 August 2004); doi:10.1038/430840a
| Full Text (HTML / PDF) |
letter The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements
Noriaki Sasai, Yoko Nakazawa, Tomoko Haraguchi and Yoshiki Sasai Nature Cell Biology6, 741–748
(August 2004); doi:10.1038/ncb1158
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article Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
Aziz Moqrich, Taryn J Earley, James Watson, Mary Andahazy, Carey Backus, Dionisio Martin-Zanca, Douglas E Wright, Louis F Reichardt and Ardem Patapoutian Nature Neuroscience7, 812–818
(August 2004); doi:10.1038/nn1283
| Abstract | Full Text (HTML/PDF) |
article Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
Aziz Moqrich, Taryn J Earley, James Watson, Mary Andahazy, Carey Backus, Dionisio Martin-Zanca, Douglas E Wright, Louis F Reichardt and Ardem Patapoutian Nature Neuroscience7, 812–818
(August 2004); doi:10.1038/nn1283
| Abstract | Full Text (HTML/PDF) |
article Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/-Pix
Qiyu Feng, Daniel Baird and Richard A Cerione The EMBO Journal Advance online publishing
(12 August 2004); doi:10.1038/sj.emboj.7600331
| Abstract | Full Text (HTML/PDF) |
letters to nature Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
Yongliang Zhang, Joseph N. Blattman, Norman J. Kennedy, Julie Duong, Thang Nguyen, Ying Wang, Roger J. Davis, Philip D. Greenberg, Richard A. Flavell and Chen Dong Nature430, 793–797
(12 August 2004); doi:10.1038/nature02764
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article CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
Qi-Jing Li, Aaron R Dinner, Shuyan Qi, Darrell J Irvine, Johannes B Huppa, Mark M Davis and Arup K Chakraborty Nature Immunology5, 791–799
(August 2004); doi:10.1038/ni1095
| Abstract | Full Text (HTML/PDF) |
news and views Self help for T cells
Eric Hailman and Paul M Allen Nature Immunology5, 780–781
(August 2004); doi:10.1038/ni0804-780
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July
letters to nature Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
Dmitry M. Korzhnev , Xavier Salvatella, Michele Vendruscolo, Ariel A. Di Nardo, Alan R. Davidson, Christopher M. Dobson and Lewis E. Kay Nature430, 586–590
(29 July 2004); doi:10.1038/nature02655
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article Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase
Min-Seon Kim, Joong-Yeol Park, Cherl Namkoong, Pil-Geum Jang, Je-Won Ryu, Hai-Sun Song, Ji-Young Yun, Il-Seong Namgoong, Joohun Ha, In-Sun Park, In-Kyu Lee, Benoit Viollet, Jang Hyun Youn, Hong-Kyu Lee and Ki-Up Lee Nature Medicine10, 727–733
(July 2004); doi:10.1038/nm1061
| Abstract | Full Text (HTML/PDF) |
news and views Cellular energy sensor balances the scales
Caroline J Small, David Carling and Stephen R Bloom Nature Medicine10, 681–682
(July 2004); doi:10.1038/nm0704-681
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letter A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone
Christine Dos Santos, Laurent Essioux, Cécile Teinturier, Maïté Tauber, Vincent Goffin and Pierre Bougnères Nature Genetics36, 720–724
(July 2004); doi:10.1038/ng1379
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letter BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Darren J Baker, Karthik B Jeganathan, J Douglas Cameron, Michael Thompson, Subhash Juneja, Alena Kopecka, Rajiv Kumar, Robert B Jenkins, Piet C de Groen, Patrick Roche and Jan M van Deursen Nature Genetics36, 744–749
(July 2004); doi:10.1038/ng1382
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news and views Aging counts on chromosomes
Oscar Fernandez-Capetillo and André Nussenzweig Nature Genetics36, 672–674
(July 2004); doi:10.1038/ng0704-672
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review article A new modality for immunosuppression: targeting the JAK/STAT pathway
John J. O'Shea, Marko Pesu, Dominic C. Borie and Paul S. Changelian Nature Reviews Drug Discovery3, 555–564
(July 2004); doi:10.1038/nrd1441
| Abstract | Full Text (HTML / PDF) |
article GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation
Isao Usui, Takeshi Imamura, Hiroaki Satoh, Jie Huang, Jennie L Babendure, Christopher J Hupfeld and Jerrold M Olefsky The EMBO Journal23, 2821–2829
(July 2004); doi:10.1038/sj.emboj.7600297
| Abstract | Full Text (HTML/PDF) |
letters to nature An SCF-like ubiquitin ligase complex that controls presynaptic differentiation
Edward H. Liao, Wesley Hung, Benjamin Abrams and Mei Zhen Nature430, 345–350
(15 July 2004); doi:10.1038/nature02647
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letter ATR and ATM regulate the timing of DNA replication origin firing
David Shechter, Vincenzo Costanzo and Jean Gautier Nature Cell Biology6, 648–655
(July 2004); doi:10.1038/ncb1145
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news and views Sleeping policemen for DNA replication?
Daniel Fisher and Marcel Méchali Nature Cell Biology6, 576–577
(July 2004); doi:10.1038/ncb0704-576
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review article Calcium, kinases and nodulation signalling in legumes
Giles E. D. Oldroyd and J. Allan Downie Nature Reviews Molecular Cell Biology5, 566–576
(July 2004); doi:10.1038/nrm1424
| Abstract | Full Text (HTML / PDF) |
letter p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci
Cristiano Simone, Sonia Vanina Forcales, David A Hill, Anthony N Imbalzano, Lucia Latella and Pier Lorenzo Puri Nature Genetics36, 738–743
(July 2004); doi:10.1038/ng1378
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news and views Something to SNF about
Mark A Gillespie and Michael A Rudnicki Nature Genetics36, 676–677
(July 2004); doi:10.1038/ng0704-676
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letters to nature Cyclin-dependent kinases regulate the antiproliferative function of Smads
Isao Matsuura , Natalia G. Denissova , Guannan Wang , Dongming He , Jianyin Long and Fang Liu Nature430, 226–231
(08 July 2004); doi:10.1038/nature02650
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letter Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation
Neil Phillips, Richard D. Hayward and Vassilis Koronakis Nature Cell Biology6, 618–625
(July 2004); doi:10.1038/ncb1148
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news and views Cancer: Understanding the target
M R Stratton & P A Futreal Nature430, 30
(01 July 2004); doi:10.1038/nrm1423
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letters to nature PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
Xiaowei Lu, Annette G. M. Borchers, Christine Jolicoeur, Helen Rayburn, Julie C. Baker & Marc Tessier-Lavigne Nature430, 93–98
(01 July 2004); doi:10.1038/nature02677
| Abstract | Full Text (HTML / PDF) |
article LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1
Xiaolong Yang, Kuanping Yu, Yawei Hao, Da-ming Li, Rodney Stewart, Karl L. Insogna and Tian Xu Nature Cell Biology6, 609–617
(July 2004); doi:10.1038/ncb1140
| Abstract | Full Text (HTML/PDF) |
letter Centriolar SAS-5 is required for centrosome duplication in C. elegans
Marie Delattre, Sebastian Leidel, Khursheed Wani, Karine Baumer, Jeannine Bamat, Heinke Schnabel, Richard Feichtinger, Ralf Schnabel and Pierre Gönczy Nature Cell Biology6, 656–664
(July 2004); doi:10.1038/ncb1146
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news and views Uncoiling centriole duplication
Bruce Nash and Bruce Bowerman Nature Cell Biology6, 573–575
(July 2004); doi:10.1038/ncb0704-573
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June
review article Juxtamembrane autoinhibition in receptor tyrosine kinases
Stevan R. Hubbard Nature Reviews Molecular Cell Biology5, 464–471
(June 2004); doi:10.1038/nrm1399
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news and views Balancing muscle hypertrophy and atrophy
Eric P Hoffman and Gustavo A Nader Nature Medicine10, 584–585
(June 2004); doi:10.1038/nm0604-584
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article Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
Hongbing Wang, Gregory D Ferguson, Victor V Pineda, Paige E Cundiff and Daniel R Storm Nature Neuroscience7, 635–642
(June 2004); doi:10.1038/nn1248
| Abstract | Full Text (HTML/PDF) |
letter Memo mediates ErbB2-driven cell motility
Romina Marone, Daniel Hess, David Dankort, William J. Muller, Nancy E. Hynes and Ali Badache Nature Cell Biology6, 515–522
(June 2004); doi:10.1038/ncb1134
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technical report Bioluminescent imaging of Cdk2 inhibition in vivo
Guo-Jun Zhang, Michal Safran, Wenyi Wei, Erik Sorensen, Peter Lassota, Nikolai Zhelev, Donna S Neuberg, Geoffrey Shapiro, and William G Kaelin Jr Nature Medicine10, 643–648
(June 2004); doi:10.1038/nm1047
| Abstract | Full Text (HTML/PDF) |
news and views Targeting tumors: seeing the light
Charlotte Schubert Nature Medicine10, 580
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article The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation
Ken Matsumoto, Shigeki Nishihara, Mika Kamimura, Tomoki Shiraishi, Takao Otoguro, Masayuki Uehara, Yukiko Maeda, Keiko Ogura, Andrew Lumsden and Toshihiko Ogura Nature Neuroscience7, 605–612
(June 2004); doi:10.1038/nn1249
| Abstract | Full Text (HTML/PDF) |
review article Modulation of signalling by Sprouty: a developing story
Hong Joo Kim and Dafna Bar-Sagi Nature Reviews Molecular Cell Biology5, 441–450
(June 2004); doi:10.1038/nrm1400
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article mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane and William R Sellers Nature Medicine10, 594–601
(June 2004); doi:10.1038/nm1052
| Abstract | Full Text (HTML/PDF) |
news and views TORward AKTually useful mouse models
Ingo K Mellinghoff and Charles L Sawyers Nature Medicine10, 579–580
(June 2004); doi:10.1038/nm0604-579
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review article A renaissance for SRC
Timothy J. Yeatman Nature Reviews Cancer4, 470–480
(June 2004); doi:10.1038/nrc1366
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article Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane and David C Rubinsztein Nature Genetics36, 585–595
(June 2004); doi:10.1038/ng1362
| Abstract | Full Text (HTML/PDF) |
news and views Huntingtin aggregates ask to be eaten
Carson C Thoreen and David M Sabatini Nature Genetics36, 553–554
(June 2004); doi:10.1038/ng0604-553
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review article GSK3 inhibitors: development and therapeutic potential
Philip Cohen and Michel Goedert Nature Reviews Drug Discovery3, 479–487
(June 2004); doi:10.1038/nrd1415
| Abstract | Full Text (HTML / PDF) |
article Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita and Issei Komuro Nature Cell Biology6, 499–506
(June 2004); doi:10.1038/ncb1137
| Abstract | Full Text (HTML/PDF) |
review article Polo-like kinases and the orchestration of cell division
Francis A. Barr, Herman H. W. Silljé and Erich A. Nigg Nature Reviews Molecular Cell Biology5, 429–441
(June 2004); doi:10.1038/nrm1401
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research article Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
Peter M Smith-Jones, David B Solit, Timothy Akhurst, Farzana Afroze, Neal Rosen and Steven M Larson Nature Biotechnology22, 701–706
(June 2004); doi:10.1038/nbt968
| Abstract | Full Text (HTML/PDF) |
news and views An image worth a thousand lives?
Lisa A Hammond, Sean X Cavanaugh and Charles R Thomas Jr Nature Biotechnology22, 677–678
(June 2004); doi:10.1038/nbt0604-677
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May
article The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
Heather J Hinton, Dario R Alessi and Doreen A Cantrell Nature Immunology5, 539–545
(May 2004); doi:10.1038/ni1062
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article Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
Yiguo Hu, Yuhua Liu, Shawn Pelletier, Elisabeth Buchdunger, Markus Warmuth, Doriano Fabbro, Michael Hallek, Richard A Van Etten and Shaoguang Li Nature Genetics36, 453–461
(May 2004); doi:10.1038/ng1343
| Abstract | Full Text (HTML/PDF) |
news and views Src kinases in Ph+ lymphoblastic leukemia
Michael Deininger Nature Genetics36, 440–441
(May 2004); doi:10.1038/ng0504-440
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article Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, Christopher Vearing, Detlef Geleick, David A Feldheim, Andrew W Boyd, Mark Henkemeyer and Dimitar B Nikolov Nature Neuroscience7, 501–509
(May 2004); doi:10.1038/nn1237
| Abstract | Full Text (HTML/PDF) |
news and views Eph-ephrin promiscuity is now crystal clear
Elena B Pasquale Nature Neuroscience7, 417–418
(May 2004); doi:10.1038/nn0504-417
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letters to nature Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases
Letizia Lanzetti, Andrea Palamidessi, Liliana Areces, Giorgio Scita and Pier Paolo Di Fiore Nature429, 309–314
(20 May 2004); doi:10.1038/nature02542
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article RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
Etienne Meylan, Kim Burns, Kay Hofmann, Vincent Blancheteau, Fabio Martinon, Michelle Kelliher and Jürg Tschopp Nature Immunology5, 503–507
(May 2004); doi:10.1038/ni1061
| Abstract | Full Text (HTML/PDF) |
news and views Toll signaling: RIPping off the TNF pathway
Gregory M Barton and Ruslan Medzhitov Nature Immunology5, 472–474
(May 2004); doi:10.1038/ni0504-472
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letter Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
Ram Kumar Mathur, Amit Awasthi, Pallavi Wadhone, B Ramanamurthy and Bhaskar Saha Nature Medicine10, 540–544
(May 2004); doi:10.1038/nm1045
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perspectives Timeline: The discovery of receptor tyrosine kinases: targets for cancer therapy
Andreas Gschwind, Oliver M. Fischer and Axel Ullrich Nature Reviews Cancer4, 361–370
(May 2004); doi:10.1038/nrc1360
| Abstract | Full Text (HTML / PDF) |
brief communication Circadian regulation of GABAA receptor function by CKIε-CKIδ in the rat suprachiasmatic nuclei
Ke Ning, Lei Li, Mingxia Liao, Baosong Liu, John G Mielke, Yonghong Chen, Ying Duan, Youssef H El-Hayek and Qi Wan Nature Neuroscience7, 489–490
(May 2004); doi:10.1038/nn1236
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review article The TOR pathway: a target for cancer therapy
Mary-Ann Bjornsti and Peter J. Houghton Nature Reviews Cancer4, 335–348
(May 2004); doi:10.1038/nrc1362
| Abstract | Full Text (HTML / PDF) |
letters to nature Mechanotransduction through growth-factor shedding into the extracellular space
Daniel J. Tschumperlin, Guohao Dai, Ivan V. Maly, Tadashi Kikuchi, Lily H. Laiho, Anna K. McVittie, Kathleen J. Haley, Craig M. Lilly, Peter T. C. So, Douglas A. Lauffenburger, Roger D. Kamm and Jeffrey M. Drazen Nature429, 83–86
(06 May 2004); doi:10.1038/nature02543
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letter In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C
Youzhong Yuan, Hongmei Shen, David S. Franklin, David T. Scadden and Tao Cheng Nature Cell Biology6, 436–442
(May 2004); doi:10.1038/ncb1126
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April
article GADD45β/GADD45γ and MEKK 4 comprise a genetic pathway mediating STAT4-independent IFN-γ production in T cells
Hongbo Chi, Binfeng Lu, Mutsuhiro Takekawa, Roger J Davis and Richard A Flavell EMBO journal23, 1576–1586
(April 2004); doi: 10.1038/sj.emboj.7600173
| Abstract | Full Text (HTML/PDF) |
news and views Cancer: Enzymes play molecular tag
Deborah K. Morrison Nature428, 813–815
(22 April 2004); doi:10.1038/428813a
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review article Src kinases: a hub for NMDA receptor regulation
Michael W. Salter and Lorraine V. Kalia Nature Reviews Neuroscience5, 317–328
(April 2004); doi:10.1038/nrn1368
| Abstract | Full Text (HTML / PDF) |
article Regulation of the p300 HAT domain via a novel activation loop
Paul R Thompson, Dongxia Wang, Ling Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert G Roeder, Jiemin Wong, Massimo Levrero, Vittorio Sartorelli, Robert J Cotter and Philip A Cole Nature Structural and Molecular Biology11, 308–315
(April 2004); doi:10.1038/nsmb740
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news and views Is acetylation the key to opening locked gates?
B Franklin Pugh Nature Structural and Molecular Biology11, 298–300
(April 2004); doi:10.1038/nsmb0404-298
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letters to nature IkB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
Alok K. Sil, Shin Maeda, Yuji Sano, Dennis R. Roop and Michael Karin Nature428, 660–664
(08 April 2004); doi:10.1038/nature02421
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letter PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3
Ingrid Remy, Annie Montmarquette and Stephen W. Michnick Nature Cell Biology6, 358–365
(April 2004); doi:10.1038/ncb1113
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letter Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Andrew R. Conery, Yanna Cao, E. Aubrey Thompson, Courtney M. Townsend, Jr Tien C. Ko and Kunxin Luo Nature Cell Biology6, 366–372
(April 2004); doi:10.1038/ncb1117
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article CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer
Zhongmin Guo, Jürgen F. Linn, Guojun Wu, Sarah L Anzick, Claus F Eisenberger, Sarel Halachmi, Yoram Cohen, Alexey Fomenkov, Mohammad Obaidul Hoque, Kenji Okami, Gabriel Steiner, James M Engles, Motonabu Osada, Chulso Moon, Edward Ratovitski, Jeffrey M Trent, Paul S Meltzer, William H Westra, Lambertus A Kiemeney, Mark P Schoenberg, David Sidransky and Barry Trink Nature Medicine10, 374–381
(April 2004); doi:10.1038/nm1010
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article Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway
Dmitry V Bulavin, Crissy Phillips, Bonnie Nannenga, Oleg Timofeev, Larry A Donehower, Carl W Anderson, Ettore Appella and Albert J Fornace Jr. Nature Genetics36, 343–350
(April 2004); doi:10.1038/ng1317
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news and views Wip-ing out cancer
René Bernards Nature Genetics36, 319–320
(April 2004); doi:10.1038/ng0404-319
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research article An improved cyan fluorescent protein variant useful for FRET
Mark A Rizzo, Gerald H Springer, Butch Granada and David W Piston Nature Biotechnology22, 445–449
(April 2004); doi:10.1038/nbt945
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letters to nature AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Young-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J. Birnbaum, Bettina J. Stuck and Barbara B. Kahn Nature428, 569–574
(01 April 2004); doi:10.1038/nature02440
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review article AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
Neil Ruderman and Marc Prentki Nature Reviews Drug Discovery3, 340–351
(April 2004); doi:10.1038/nrd1344
| Abstract | Full Text (HTML / PDF) |
article p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
Eilyn R Lacy, Igor Filippov, William S Lewis, Steve Otieno, Limin Xiao, Sonja Weiss, Ludger Hengst and Richard W Kriwacki Nature Structural and Molecular Biology11, 358–364
(April 2004); doi:10.1038/nsmb746
| Abstract | Full Text (HTML/PDF) |
March
letters to nature Functional interactions between receptors in bacterial chemotaxis
Victor Sourjik and Howard C. Berg Nature428, 437–441
(25 March 2004); doi:10.1038/nature02406
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letter Correcting improper chromosome-spindle attachments during cell division
Michael A. Lampson, Kishore Renduchitala, Alexey Khodjakov and Tarun M. Kapoor Nature Cell Biology6, 232–237
(March 2004); doi:10.1038/ncb1102
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news and views Correcting SYNful attachments
Sue Biggins Nature Cell Biology6, 181–183
(March 2004); doi:10.1038/ncb0304-181
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letter Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination
Anatoliy Li and J. Julian Blow Nature Cell Biology6, 260–267
(March 2004); doi:10.1038/ncb1100
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article Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
Patrick S Costello, Robert H Nicolas, Yasuyuki Watanabe, Ian Rosewell and Richard Treisman Nature Immunology5, 289–298
(March 2004); doi:10.1038/ni1038
| Abstract | Full Text (HTML/PDF) |
review article A census of human cancer genes
P. Andrew Futreal, Lachlan Coin, Mhairi Marshall, Thomas Down, Timothy Hubbard, Richard Wooster, Nazneen Rahman and Michael R. Stratton Nature Reviews Cancer4, 177–183
(March 2004); doi:10.1038/nrc1299
| Abstract | Full Text (HTML / PDF) |
review article MAPK cascade signalling and synaptic plasticity
Gareth M. Thomas and Richard L. Huganir Nature Reviews Neuroscience5, 173–183
(March 2004); doi:10.1038/nrn1346
| Abstract | Full Text (HTML / PDF) |
letters to nature Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
Hans-Guido Wendel, Elisa de Stanchina, Jordan S. Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier and Scott W. Lowe Nature428, 332–337
(18 March 2004); doi:10.1038/nature02369
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news and views Cancer: Survival pathways meet their end
Frank McCormick Nature428, 267–269
(18 March 2004); doi:10.1038/428267a
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letters to nature The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J. Kaufman, Lars Eckmann, Donald G. Guiney and Michael Karin Nature428, 341–345
(18 March 2004); doi:10.1038/nature02405
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article VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
Elizabeth A Harrington, David Bebbington, Jeff Moore, Richele K Rasmussen, Abi O Ajose-Adeogun, Tomoko Nakayama, Joanne A Graham, Cecile Demur, Thierry Hercend, Anita Diu-Hercend, Michael Su, Julian M C Golec and Karen M Miller Nature Medicine10, 262–267
(March 2004); doi:10.1038/nm1003
| Abstract | Full Text (HTML/PDF) |
news and views Aurora kinases dawn as cancer drug targets
Edward A Sausville Nature Medicine10, 234–235
(March 2004); doi:10.1038/nm0304-234
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article PKC-α regulates cardiac contractility and propensity toward heart failure
Julian C Braz, Kimberly Gregory, Anand Pathak, Wen Zhao, Bogachan Sahin, Raisa Klevitsky, Thomas F Kimball, John N Lorenz, Angus C Nairn, Stephen B Liggett, Ilona Bodi, Su Wang, Arnold Schwartz, Edward G Lakatta, Anna A DePaoli-Roach, Jeffrey Robbins, Timothy E Hewett, James A Bibb, Margaret V Westfall, Evangelia G Kranias and Jeffery D Molkentin Nature Medicine10, 248–254
(March 2004); doi:10.1038/nm1000
| Abstract | Full Text (HTML/PDF) |
news and views Calcium handler mishandles heart
Hunter C Champion and David A Kass Nature Medicine10, 239–240
(March 2004); doi:10.1038/nm0304-239
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review article Targeting the checkpoint kinases: chemosensitization versus chemoprotection
Bin-Bing S. Zhou and Jiri Bartek Nature Reviews Cancer4, 216–225
(March 2004); doi:10.1038/nrc1296
| Abstract | Full Text (HTML / PDF) |
news and views Turning on FLT3
Elizabeth Grzymski Nature Structural and Molecular Biology11, 212
(March 2004); doi:10.1038/nsmb0304-212
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news and views Cell biology: A cellular choreographer
W. James Nelson Nature428, 28–29
(04 March 2004); doi:10.1038/428028a
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article MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence
Teiji Wada, Nicholas Joza, Hai-ying M. Cheng, Takehiko Sasaki, Ivona Kozieradzki, Kurt Bachmaier, Toshiaki Katada, Martin Schreiber, Erwin F. Wagner, Hiroshi Nishina and Josef M. Penninger Nature Cell Biology6, 215–226
(March 2004); doi:10.1038/ncb1098
| Abstract | Full Text (HTML/PDF) |
letter Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation
Patrizia Sini, Angela Cannas, Anthony J. Koleske, Pier Paolo Di Fiore and Giorgio Scita Nature Cell Biology6, 268–275
(March 2004); doi:10.1038/ncb1096
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article PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration
Rajeev Sivasankaran, Jiong Pei, Kevin C Wang, Yi Ping Zhang, Christopher B Shields, Xiao-Ming Xu and Zhigang He Nature Neuroscience7, 261–268
(March 2004); doi:10.1038/nn1193
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February
letters to nature OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis
Maike C. Rentel, David Lecourieux, Fatma Ouaked, Sarah L. Usher, Lindsay Petersen, Haruko Okamoto, Heather Knight, Scott C. Peck, Claire S. Grierson, Heribert Hirt and Marc R. Knight Nature427, 858–861
(26 February 2004); doi:10.1038/nature02353
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letter Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network
Charles Yeaman, M. Inmaculada Ayala, Jessica R. Wright, Frederic Bard, Carine Bossard, Agnes Ang, Yusuke Maeda, Thomas Seufferlein, Ira Mellman, W. James Nelson and Vivek Malhotra Nature Cell Biology6, 106–112
(February 2004); doi:10.1038/ncb1090
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letter Gadd45β mediates the NF-kB suppression of JNK signalling by targeting MKK7/JNKK2
Salvatore Papa, Francesca Zazzeroni, Concetta Bubici, Shanthi Jayawardena, Kellean Alvarez, Shuji Matsuda, Dung U. Nguyen, Can G. Pham, Andreas H. Nelsbach, Tiziana Melis, Enrico De Smaele, Wei-Jen Tang, Luciano D'Adamio and Guido Franzoso Nature Cell Biology6, 146–153
(February 2004); doi:10.1038/ncb1093
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article The costimulation-regulated duration of PKB activation controls T cell longevity
Jianxun Song, Shahram Salek-Ardakani, Paul R Rogers, Mary Cheng, Luk Van Parijs and Michael Croft Nature Immunology5, 150–158
(February 2004); doi:10.1038/ni1030
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letter A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma
Monique Singer, Linda D Martin, B Boris Vargaftig, Joungjoa Park, Achim D Gruber, Yuehua Li and Kenneth B Adler Nature Medicine10, 193–196
(February 2004); doi:10.1038/nm983
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article Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
Effat S Emamian, Diana Hall, Morris J Birnbaum, Maria Karayiorgou and Joseph A Gogos Nature Genetics36, 131–137
(February 2004); doi:10.1038/ng1296
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news and views Getting our AKT together in schizophrenia?
Joachim Hallmayer Nature Genetics36, 115–116
(February 2004); doi:10.1038/ng0204-115
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letter The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression
Jennifer S. Searle, Kaila L. Schollaert, Benjamin J. Wilkins and Yolanda Sanchez Nature Cell Biology6, 138–145
(February 2004); doi:10.1038/ncb1092
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letter FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
Donna J. Webb, Karen Donais, Leanna A. Whitmore, Sheila M. Thomas, Christopher E. Turner, J. Thomas Parsons and Alan F. Horwitz Nature Cell Biology6, 154–161
(February 2004); doi:10.1038/ncb1094
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news and views Modifiying NEMO
Ronald T. Hay Nature Cell Biology6, 89–91
(February 2004); doi:10.1038/ncb0204-89
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article Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction
Diane S Lidke, Peter Nagy, Rainer Heintzmann, Donna J Arndt-Jovin, Janine N Post, Hernan E Grecco, Elizabeth A Jares-Erijman and Thomas M Jovin Nature Biotechnology22, 198–203
(February 2004); doi:10.1038/nbt929
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news and views Enlightened receptor dynamics
Gal Gur and Yosef Yarden Nature Biotechnology22, 169–170
(February 2004); doi:10.1038/nbt0204-169
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article Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor
Christine C Milburn, Jérôme Boudeau, Maria Deak, Dario R Alessi and Daan M F van Aalten Nature Structural and Molecular Biology11, 193–200
(February 2004); doi:10.1038/nsmb716
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January
letter Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast
Jason Moffat and Brenda Andrews Nature Cell Biology6, 59–66
(January 2004); doi:10.1038/ncb1078
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perspectives Controlling Abl: auto-inhibition and co-inhibition?
Jean Y. J. Wang Nature Cell Biology6, 3–7
(January 2004); doi:10.1038/ncb0104-3
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article Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
Qiaojia Huang, Jianhua Yang, Yong Lin, Christopher Walker, Jinke Cheng, Zheng-gang Liu and Bing Su Nature Immunology5, 98–103
(January 2004); doi:10.1038/ni1014
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article The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
Benjamin E Turk, Thiang Yian Wong, Robert Schwarzenbacher, Emily T Jarrell, Stephen H Leppla, R John Collier, Robert C Liddington and Lewis C Cantley Nature Structural and Molecular Biology11, 60–66
(January 2004); doi:10.1038/nsmb708
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article Identification of small molecule inhibitors of anthrax lethal factor
Rekha G Panchal, Ann R Hermone, Tam Luong Nguyen, Thiang Yian Wong, Robert Schwarzenbacher, James Schmidt, Douglas Lane, Connor McGrath, Benjamin E Turk, James Burnett, M Javad Aman, Stephen Little, Edward A Sausville, Daniel W Zaharevitz, Lewis C Cantley, Robert C Liddington, Rick Gussio and Sina Bavari Nature Structural and Molecular Biology11, 67–72
(January 2004); doi:10.1038/nsmb711
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letters to nature The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
Eulália de Nadal, Meritxell Zapater, Paula M. Alepuz, Lauro Sumoy, Glòria Mas and Francesc Posas Nature427, 370–374
(22 January 2004); doi:10.1038/nature02258
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letter The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
Ralph T. Böttcher, Nicolas Pollet, Hajo Delius and Christof Niehrs Nature Cell Biology6, 38–44
(January 2004); doi:10.1038/ncb1082
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review article Regulation of the c-Abl and Bcr-Abl Tyrosine Kinases
Oliver Hantschel and Giulio Superti-Furga Nature Reviews Molecular Cell Biology5, 33–44
(January 2004); doi:10.1038/nrm1280
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article Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Noboru Sato, Laurent Meijer, Leandros Skaltsounis, Paul Greengard and Ali H Brivanlou Nature Medicine10, 55–63
(January 2004); doi:10.1038/nm979
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news and views Embryonic stem cells: staying plastic on plastic
Kinichi Nakashima, Sophia Colamarino and Fred H Gage Nature Medicine10, 23–24
(January 2004); doi:10.1038/nm0104-23
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news and views THC: moderation during implantation
Daniele Piomelli Nature Medicine10, 19–20
(January 2004); doi:10.1038/nm0104-19
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letters to nature Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
Sharon A. Matheny, Chiyuan Chen, Robert L. Kortum, Gina L. Razidlo, Robert E. Lewis and Michael A. White Nature427, 256–260
(15 January 2004); doi:10.1038/nature02237
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letter Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
Angeles Almeida, Salvador Moncada and Juan P. Bolaños Nature Cell Biology6, 45–51
(January 2004); doi:10.1038/ncb1080
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news and views No glial death with NO
Solomon H. Snyder and Sangwon Kim Nature Cell Biology6, 17–18
(January 2004); doi:10.1038/ncb0104-17
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article High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division
Henrique Veiga-Fernandes and Benedita Rocha Nature Immunology5, 31–37
(January 2004); doi:10.1038/ni1015
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article Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway
Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda, Naohisa Tamura, Yoshihiro Ogawa and Kazuwa Nakao Nature Medicine10, 80–86
(January 2004); doi:10.1038/nm971
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article Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai, Zhi-Min Yuan, Jolanta Bondaruk, Fumio Suzuki, Satoshi Fujii, Ralph B Arlinghaus, Bogdan A Czerniak and Subrata Sen Nature Genetics36, 55–62
(January 2004); doi:10.1038/ng1279
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review article The IKK NF-kB system: a treasure trove for drug development
Michael Karin, Yumi Yamamoto and Q. May Wang Nature Reviews Drug Discovery3, 17–26
(January 2004); doi:10.1038/nrd1279
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letters to nature Bcl10 activates the NF-kB pathway through ubiquitination of NEMO
Honglin Zhou, Ingrid Wertz, Karen O'Rourke, Mark Ultsch, Somasekar Seshagiri, Michael Eby, Wei Xiao and Vishva M. Dixit Nature427, 167–171
(08 January 2004); doi:10.1038/nature02273
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review article Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling
G. Tim Bowden Nature Reviews Cancer4, 23–35
(January 2004); doi:10.1038/nrc1253
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article Hippocampal plasticity requires postsynaptic ephrinBs
Ilona C Grunwald, Martin Korte, Giselind Adelmann, Anne Plueck, Klas Kullander,
Ralf H Adams, Michael Frotscher, Tobias Bonhoeffer and Rüdiger Klein Nature Neuroscience7, 33–40
(January 2004); doi:10.1038/nn1164
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